A 4-year old girl presents with severe vomiting after a viral fever of 5 days. She is hospitalized and develops cerebral edema. Liver biopsy is most likely to demonstrate w hich of the following?
Centrizonal hemorrhagic necrosis
Non-alcoholic steatohepatitis
Ring granulomas
Marked microvesicular steatosis
Ans. d. Marked microvesicular steatosisReye!s Syndrome (Fatty Liver with Encephalopathy):Acute illness, encountered exclusively in childrenOnset usually follows an upper respiratory tract infection, especially influenza or chickenpoxdegCharacterized clinically by: Vomitingdeg, signs of progressive CNS damagedeg, signs of hepatic injurydeg, hypoglycemiadegCause is unknown, although viral agents and salicylates have been implicate&Morphologically, extensive vacuolization of the liver and renal tubulesdeg.Extensive accumulation of fat droplets within hepatocytes (microvesicular steatosis)