A 16 years old girl came for evaluation of primary amenorrhea. She was having hirsutism, irregular bleeding and infeility, diagnosed as PCOS. Which of the following drugs should not be given?
Spironolactone
Tamoxifen
OCPs
Clomiphene citrate
Answer- B. TamoxifenMedical Treatment of PCOSEstrogen best given with progesterone (combined OCPs) with no androgenic propeiesHirsutism is treated with cyproterone acetate or spironolactone.Infeility is treated with Clomiphene, 80% ovulate and 40% conceive.In Clomiphene failed group, ovulation can be induced with FSH or GnRH analogues.Metformin treats the root cause of PCOS, rectifies endocrine and metabolic functions and improves feility and isdrug of choice.