Which one of the following is a gender-specific side-effect of valproate?
Polycystic ovarian syndrome
Alopecia
Weight loss
Tremor
Ans: A. Polycystic ovarian syndrome Side-effects of Valproic AcidMC side effects are transient GI symptoms (anorexia, nausea & vomiting)Effects on the CNS: Sedation, ataxia & Rash, alopecia Stimulation of appetite & weight gain.Increase the chance of polycystic ovary syndrome (PCOS) in women with epilepsy or bipolar disorders Elevation of hepatic transaminases, microvesicular steatosisAcute pancreatitisHyperammonemiaNeural tube defects