Acetyl choline release can be increased from presynaptic membrane by:
Blocking voltage gated Na+ channels on presynaptic membrane
Blocking voltage gated Ca+ channels on presynaptic membrane
Blocking voltage gated K+ channels on presynaptic membrane
Blocking voltage gated CI- channels on presynaptic membrane
Blocking voltage gated K+ channels on presynaptic membrane | K+ exit stops | Membrane does not get hyperpolarized |Continued Ach release When an AP depolarizes the presynaptic membrane=Ca++ channel open=allow release of neurotransmitter=from terminal=into synaptic cleft=forming bridge for the vesicles and release sites of a depolarized membrane. Blocking voltage gated Na++ channels will block the AP propagation Chloride channels are present=on the post synaptic membrane.