A young man was on high protein diet and raw eggs. After 3 days he developed weakness. Blood investigation revealed hypoglycemia. Hypoglycemia is due to inhibition of which of the following enzymes
Glucose 6 phosphatase
Glycogen phosphorylase
Pyruvate Carboxylase
Glucokinase
Ans- c- Pyruvate Carboxylase.When gluconeogenesis is elevated due to low blood glucose levels, the activation by acetyl-CoA of pyruvate carboxylase, which catalyzes the conversion of pyruvate to oxaloacetate, paially alletes this problem, but in conditions such as starvation and untreated diabetes mellitus, ketone bodies are overproduced and cause ketosis.