Which of the following statements regarding Kawasaki disease is true –
Associated with coronary artery aneurysm in up to 25% of untreated cases
It is the most common cause of vasculitis in children
IV immunoglobulins are recommended only if coronary artery is involved
Lymph node biopsy is used for diagnosis
"Coronary artery aneurysm develop in up to 25% of untreated patients" - Nelson 
Kawasaki disease

Kawasaki disease, also known as lymph node syndrome, mucocutaneous-lymph node syndrome, and infant polyarteritis, is a poorly understood self-limited vasculitis that affects many organs, including the skin mucous membrane, lymph nodes, heart and blood vessel walls.
It is usually seen in children younger than 5 years.
Kawasaki disease predominantly affect medium sized vessels, but may also affect small or large vessels.

Presentation

Presenting features may be divided into : -

1. Mucocutaneous, lymphnode involved

Often begins with high grade fever.


Erythma of mouth, red cracked lips, a strawberry tongue.
Bilateral conjuctival injection with iritis and keratic precipitate.
Red palms and soles
Rash, which may take many forms (but not vesicular), on trunk.
Rash with peeling of skin in genital area perineal desquamation.
Cervical lymphadenopathy
Beau's lines (transverse grooves on nails).


Arthralgia

2. Heart

The cardiac complications are the most important aspect of the disease.
These are due to coronary vasculitis.


Vasculitis causes coronary ectasia and coronary artery aneurism.


Aneurism may lead to MI and sudden death.


Myocarditis, pericarditis with small pericardial effusion.


Valvular regurgitation

Laborator findings
Lymph node biopsy does not aid the diagnosis of Kawasaki disease (not used)

The diagnosis of Kawasaki disease is based on presence of specific clinical signs (Clinical criteria).
These is no specific laboratory test