Drug of choice for scrub typhus is:
Azithromycin
Ciprofloxacin
Doxycycline
Chloramphenicol
Scrub typhus is caused by rickettsia. DOC for rickettsia is Doxycycline(tetracycline). It is the DOC for all kind of typhus like endemic typhus, epidemic typhus, and other rickettsial infections like Q fever, rocky mountain spotted fever. Azithromycin is a macrolide and a protein synthesis inhibitor. Ciprofloxacin is a fluoroquinolone. Chloramphenicol is also a protein synthesis inhibitor.