Event of early acquisition of malignant phenotype of epithelium is an expression of:
Cyclin a
Cyclin b
Cyclin c
Cyclin d
Conclusion of this study was Deregulation of the p16/ pRb/cyclin DI pathway is an early event in acquisition of dysplasia, but deregulation of both pRb and p53 pathway is associated with malignant transformation and adverse prognosis in oral tumorigenesis.