A healthy volunteer was taken for a blood experiment. A history was taken from the volunteer before the experiment regarding exposure of NSAlDs, which he specifically denied. But on testing, the BT was found to be increased All of the following can be causative agent except:
Theophylline
Cephalosporin
Anti-depressants
Multivitamins containing Vitamin K
Ans: D. Multivitamins containing Vitamin K(Ref. Goodman Gilman 12/e p1043, 1499; Katzung 13/e p1145)Routine use of multivitamins with Vitamin K doesn't cause thrombocytopenia.Vitamin K:Used as Warfarin antidote (anticoagulant) excess.Drug-induced immune thrombocytopenia (DITP):In acute thrombocytopenia patients.Most Common Causes of DITPAntiplateletAbciximab, Eptifibatide, TirofibanAnalgesicsAcetaminophen, Ibuprofen, NaproxenAntibioticAmpicillin, Piperacillin, Ethambutol, CephalosporinsDrugs acting on CNSCarbamazepine, Haloperidol, Phenytoin, AntidepressantsAnti-CancerIrinotecan, Oxaliplatin (selective thrombocytopenia apa from pancytopenia)