Which of the following structure is disrupted by Vibrio cholerae?
Hemi desmosome
Gap junctions
Zona occludens
Zona adherens
Ans: C. Zona occludens(Ref Sleisenger and Fordtran's textbook of Gastrointestinal and Liver Disease 10/e p1903).vibrio cholerae also produces additional toxins that may contribute to disease, including the zonula occludens toxin (ZOT) that alters intestinal permeability by acting on intestinal epithelial cells tight junctions, and the accessory choleraendotoxin (ACE)." Cholera toxin:Vibrio cholerae secretes enterotoxin protein.Encoded by bacteriophage (CT Xfi resident in V. cholera).Enterotoxin:Made up of 1A subunit (composed of 1A1 & 1 A2 peptide joined by disulfide link) & 5B subunits.Other toxins:Zonula occludens toxin (ZOT):Alters intestinal permeability by acting on intestinal epithelial cells tight junctions.Accessory cholera endotoxin (ACE).