The most common mode of spread of retinoblastoma:
Optic nerve invasion
Lymphatics
Vascular
Direct invasion
Ans: A. Optic nerve invasion(Ref Kanski 7/e p510-517; Yanoff and Duker 4/e p793)Most common mode of retinoblastoma spread-By optic nerve invasion.Direct extension by continuity to optic nerve & brain seen.Retinoblastoma:Primary malignant intraocular neoplasm.Arising from immature retinoblasts within developing retina.Most common primary intraocular malignancy of childhood in all-racial groups.Strong tendencies invading brain optic nerve & metastasize widely.