A patient has normal blood glucose level as estimated by glucose-oxidase peroxidase method, shows positive Benedicts test in urine. Which of the following is the most likely cause?
Fructosemia
Denaturation of glucose
Galactosemia
False positive
Ans: C. Galactosemia(Ref Harper 30, e p205,- Actsan 20,c p726,- Harrison I9/e p433e-5)Galactosemia:Apa from glucose, both fructose & galactose gives positive Benedict's test.Classic galactosemia:Caused by galactose 1-phosphate uridyl transferase (GALT) deficiency.Diagnosis:Urine of patient shows reducing sugar (galactose) - Detected by Benedict's reagent.Negative glucose oxidase test - Specific for glucose.Presence of reducing sugar (galactose) in urine.