A neonate on routine examination at bih was found to have hepatomegaly. Rest of the examination was essentially unremarkable. On investigations, Anti-HCMV antibodies were found to be positive. What sequelae in later life is the child at risk of?
Renal failure
Mental retardation
Hepatic fibrosis
Sensorineural hearing loss
Ans: D. Sensorineural hearing loss (Ref: (Ghai 8/e p272 ; Nelson 20/e p 592-1594)Positive human cytomegalovirus (HCMV) antibodies at bih - Suggestive of congenital asymptomatic CMV infection.Symptomatic child at increased risk a Develops mental retardation.Asymptomatic child is at as high as 7% risk a Develop sensorineural hearing loss.Congenital CMV infection:Characteristic signs & symptoms:Clinically manifested infections - Intrauterine growth restriction, prematurity, hepatosplenomegaly, jaundice, blueberry muffin--like rash, thrombocytopenia and purpura, microcephaly & intracranial calcifications.Neurologic problems:Chorioretinitis, sensorineural hearing loss & mild increases in cerebrospinal fluid protein.