Vasopressin antagonist acts on which pa of the nephron?
Proximal convoluted tubule
Distal convoluted tubule
Coical collecting tubule
Medullary collecting duct
Answer- D (Medullary collecting duct)'The mechanism by which vasopressin exes its anti-diuretic effect is activated by V2 receptors and involves the inseion of aquaporin-2 into the apical (luminal) membranes at the principle cells of the collecting duct.'