Okay, let's tackle this math problem. We're starting with 72245 and subtracting 12600.

Step 1: We'll start by subtracting the digit 0 and the borrow 0 from 5 in column 1 and get 5.
5 is the first digit of our result.

Step 2: We'll start by subtracting the digit 0 and the borrow 0 from 4 in column 2 and get 4.
4 is the next digit of our result.

Step 3: We'll start by subtracting the digit 6 and the borrow 0 from 2 in column 3 and get -4.
We add -4 to 10 and get 6 as the next digit of the result.

Step 4: We'll start by subtracting the digit 2 and the borrow 1 from 2 in column 4 and get -1.
We add -1 to 10 and get 9 as the next digit of the result.

Step 5: We'll start by subtracting the digit 1 and the borrow 1 from 7 in column 5 and get 5.
5 is the next digit of our result.

So, 72245 - 12600 = 59645.