 a jewellery store in Rome in 1995 to wear during shooting of the film Daylight. Stallone ordered a small batch of such watches with his signature on the case back, called Slytech. He offered them as gifts to friends, including Arnold Schwarzenegger. The watch gained rapid popularity, and Officine Panerai was eventually taken over by Richemont in 1997.

Panerai has four major lines of watches, Historic, Contemporary, Manifattura and Special Editions. Panerai issues Special Editions every year. In 2006 it issued the 1936 California Dial Radiomir special edition, a reissue of the first Panerai model ever presented to the Italian Marina Militare. This model was limited to a run of 1936 units.

Aficionados of Panerai are known as “Paneristi”, a term coined along the lines of “Ferraristi”.

When the contract between Girard-Perregaux and Ferrari expired a new partnership was signed with Panerai to develop, manufacture and distribute watches under the Ferrari trademark. A New York representative for the watch company has called Panerai the official timekeeper to Ferrari. These wristwatches, available in the US from early August 2006, have 11 models and cost between $5,300 and $26,500. Panerai Ferrari watches are divided into two collections: Granturismo and Scuderia.

Panerai watches are amongst the most scarce in the world. In fact, the watch manufacturer can lay claim to being the most elusive watch brand globally - regularly producing fewer watches than the market demands. Retailers only receive a few pieces each per year and it is not uncommon for long customer waiting lists for popular models.

Panerai Official Website<|endoftext|>Covid-19 has impacted our lives in various ways. People are forced to stay home, children can’t go to school, hospitals have been fighting to keep everyone as healthy as possible during this time, and much more. However, the virus has also affected the economy. Some of the worst-hit are the restaurant, hospitality, travel, farming, and hospitality industries. Companies in these industries have had to lay off millions of workers all around the country.

When millions of people are out of work, this is impactful for the real estate market; rental properties more specifically. At Excalibur Homes, we always try to keep our clients and partners up-to-date on the current and future Atlanta real estate trends, so that they can back the best investments possible. If you are looking to invest in some rental properties at this time, we recommend putting your money in single-family rental properties.

Atlanta's Experts

As many are exiting the workforce, it may get more difficult for tenants to pay rent. While a large percentage of people have been able to continue to pay their rent, we suspect that this may change in the future. This with other factors, such as demographics, we suspect that single-family rental properties will become more desirable to tenants.

Some have speculated that multi-family properties will see a 6% NOI decline in 2021. For the next two to three years, single-family rental properties are predicted to outpace multi-family properties.

The recession and pandemic have had a less severe impact on the single-family rental market, which will allow landlords in this sector to retain most of the pricing power.

Ways to Fund Your Real Estate Deals

Contact Excalibur Homes for more information!<|endoftext|>Vahdettin Budaks were born in 1977, 1976, 1974 and 1968 respectively and were serving their prison sentences in Nazilli at the time of their applications to the Court. The police officers at the Anti-Terror branch of the Antalya Security Directorate arrested Tayyip Ölmez, Vahdettin Budak, Songül Karatağna and Mehmet Emin Yalçın and placed them in custody on 22 February, 13 March, 12 April and 24 April 1998 respectively. The Antalya Magistrates’ Court ordered the remand in custody of Tayyip Ölmez, Vahdettin Budak, Songül Karatağna and Mehmet Emin Yalçın on 27 February, 22 March, 21 April and 29 April 1998 respectively. By indictments dated 24 March, 8 May, 17 May and 22 May 1998 the public prosecutor at the İzmir State Security Court accused Vahdettin Budak, Songül Karatağna and Mehmet Emin Yalçın of membership of an illegal organisation and Tayyip Ölmez of aiding and abetting an illegal organisation. He requested that Vahdettin Budak be convicted and sentenced under Article 125 of Criminal Code.<|endoftext|>Glance: photo etch, intaglio, chine collé, 4" x 4", 2010

These editions explore the ambiguous relationship between words and images as sources of meaning, and often integrates autobiographical elements. In form my prints balance photographic material with drawings or accidental marks as a reference to the concepts also held in balance; concepts like the known and unknown, structure and chaos, public and private, word and image, nature and nurture, or mind and body. My themes include the insufficiency of language to communicate personal experiences, retain memory, or express grief, joy or mystery. These prints are small in scale, with a maximum dimension of 6", as many were designed for participation in international miniprint exhibitions.<|endoftext|>Appletree Logo
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Should I be concerned about Net Neutrality?

Net neutrality is the concept that the internet service providers should provide equal access to web sites regardless of content or the source. The idea is that by allowing equal access everyone, big business or small, average Joe or superstar has the same access to information on the Net.   The current net neutrality laws were carried over in the Obama administration in February of 2015 with a vote of 3-2. Under the direction of Thomas Wheeler as chairman of the Federal Communications Commission, many were concerned that his lobbyist past and membership in the National Cable and Telecommunications Association would shift net neutrality in the direction of big corporate internet providers. What happened was a strong support for the American consumer. Zoom forward two years and net neutrality is once again up for debate as a new administration makes moves to threaten access. How can changes in net neutrality impact small business?

  • Internet Service Providers (ISPs) may have the ability to limit the speeds of the internet based on websites or apps frequented.
  • IPSs may be able to charge each website for data prioritization, which would give increased speeds while browsing that site.

Still puzzled about how shifts in net neutrality could impact you? Think of it this way, on the school playground thereâ€™s always a big, threatening kid who bullies the other smaller kids into giving over their lunches, paying for his snacks or some other egregious â€˜feeâ€™ for simply breathing in his space. ISPs, if left to their own devices, may become like those playground bullies, charging small businesses exorbitant fees just to play in the same playground as everyone else.

Worse yet, because your mom only gives you enough money to buy lunch but some kids have lunch money and an allowance, the playing field shifts further because they can afford to pay more for better access to the playground.

Net neutrality means that your small business gets the same internet speeds and access as Target, Walmart and your local diner. It's fair and equal for all. Loss of net neutrality will cost your business in lost marketing opportunities, a tightened sales pipeline and less access and online sales.

Leave a Reply

Named "Small Business Accountant of the Year"

Get business financial confidence now

- Avoid shoebox accounting and learn to manage your numbers.

- Learn how to get confidence in selecting a great accountant!

<|endoftext|>Fibromyalgia and Sleep

Home >> Sleep Disorders Problems >> Fibromyalgia and Sleep

Fibromyalgia is a medical syndrome that causes widespread pain and stiffness in the muscles and joints as well as sleep problems and chronic daytime fatigue. According to the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health, between 80 and 90% of people diagnosed with fibromyalgia are middle-aged women, although it can affect both sexes and people of all ages. Fibromyalgia is a confusing and often misunderstood condition. In the past, people who sought treatment for fibromyalgia symptoms were frequently told that their symptoms were "all in the head" and that they did not represent any known disease. However, in recent decades medical studies have proven that fibromyalgia does indeed exist, and that it is estimated to affect between 2% and 6% of people worldwide.

For people with fibromyalgia, the combination of pain and sleep disturbance is a double-edged sword: the pain makes sleep more difficult and sleep deprivation exacerbates pain. The good news is that reduction in sleep disturbance is usually followed by improvement in pain symptoms. This also highlights the importance of healthy sleep and to find a sleep professional in treating this disease.

Medical researchers have long sought to clarify the association between sleep disturbance and pain. Very little is known but a few key findings indicate that sleep and pain are intricately linked. For example, studies of patients experiencing pain after surgery show disturbed sleep, reduced rapid eye movement (REM) sleep, and a normalization of sleep as recovery proceeds. People with fibromyalgia may also experience an alteration in their patterns of slow wave sleep, which is the deepest stage of sleep. In one study , researchers selectively

 it easier to work with.<|endoftext|>Panerai was founded in 1860 in Florence by Giovanni Panerai (1825–1897). It later became the official supplier to the Royal Italian Navy and expanded to building precision instruments. The company is famous for its Radiomir and Luminor watches, notable for their use by Italian commando frogmen. Mr Angelo Bonati, CEO of Panerai since their acquisition was interviwed by Lusso Magazine, “with his clipped moustache and erect bearing, I would have guessed Signor Bonati had been a military man.”

The Florence-based watchmaker produced about 300 watches, all for the Italian Marina Militare, between 1938 and 1993. By that time, the company ceased to provide watches to the Marina Militare, as they were no longer cost-effective. It then moved to launch its products to the civilian market, but remained relatively obscure until the actor Sylvester Stallone spotted and bought a Panerai Luminor in a jewellery store in Rome in 1995 to wear during shooting of the film Daylight. Stallone ordered a small batch of such watches with his signature on the case back, called Slytech. He offered them as gifts to friends, including Arnold Schwarzenegger. The watch gained rapid popularity, and Officine Panerai was eventually taken over by Richemont in 1997.

Panerai has four major lines of watches, Historic, Contemporary, Manifattura and Special Editions. Panerai issues Special Editions every year. In 2006 it issued the 1936 California Dial Radiomir special edition, a reissue of the first Panerai model ever presented to the Italian Marina Militare. This model was limited to a run of 1936 units.

Aficionados of Panerai are known as “Paneristi”, a term coined along the lines of “Ferraristi”.

When the contract between Girard-Perregaux and Ferrari expired a new partnership was signed with Panerai to develop, manufacture and distribute watches under the Ferrari trademark. A New York representative for the watch company has called Panerai the official timekeeper to Ferrari. These wristwatches, available in the US from early August 2006, have 11 models and cost between $5,300 and $26,500. Panerai Ferrari watches are divided into two collections: Granturismo and Scuderia.

Panerai watches are amongst the most scarce in the world. In fact, the watch manufacturer can lay claim to being the most elusive watch brand globally - regularly producing fewer watches than the market demands. Retailers only receive a few pieces each per year and it is not uncommon for long customer waiting lists for popular models.

Panerai Official Website<|endoftext|>Covid-19 has impacted our lives in various ways. People are forced to stay home, children can’t go to school, hospitals have been fighting to keep everyone as healthy as possible during this time, and much more. However, the virus has also affected the economy. Some of the worst-hit are the restaurant, hospitality, travel, farming, and hospitality industries. Companies in these industries have had to lay off millions of workers all around the country.

When millions of people are out of work, this is impactful for the real estate market; rental properties more specifically. At Excalibur Homes, we always try to keep our clients and partners up-to-date on the current and future Atlanta real estate trends, so that they can back the best investments possible. If you are looking to invest in some rental properties at this time, we recommend putting your money in single-family rental properties.

Atlanta's Experts

As many are exiting the workforce, it may get more difficult for tenants to pay rent. While a large percentage of people have been able to continue to pay their rent, we suspect that this may change in the future. This with other factors, such as demographics, we suspect that single-family rental properties will become more desirable to tenants.

Some have speculated that multi-family properties will see a 6% NOI decline in 2021. For the next two to three years, single-family rental properties are predicted to outpace multi-family properties.

The recession and pandemic have had a less severe impact on the single-family rental market, which will allow landlords in this sector to retain most of the pricing power.

Ways to Fund Your Real Estate Deals

Contact Excalibur Homes for more information!<|endoftext|>Glance: photo etch, intaglio, chine collé, 4" x 4", 2010

These editions explore the ambiguous relationship between words and images as sources of meaning, and often integrates autobiographical elements. In form my prints balance photographic material with drawings or accidental marks as a reference to the concepts also held in balance; concepts like the known and unknown, structure and chaos, public and private, word and image, nature and nurture, or mind and body. My themes include the insufficiency of language to communicate personal experiences, retain memory, or express grief, joy or mystery. These prints are small in scale, with a maximum dimension of 6", as many were designed for participation in international miniprint exhibitions.<|endoftext|>Appletree Logo
Subscribe to Newsletter

Start Chat

Start Chat

Should I be concerned about Net Neutrality?

Net neutrality is the concept that the internet service providers should provide equal access to web sites regardless of content or the source. The idea is that by allowing equal access everyone, big business or small, average Joe or superstar has the same access to information on the Net.   The current net neutrality laws were carried over in the Obama administration in February of 2015 with a vote of 3-2. Under the direction of Thomas Wheeler as chairman of the Federal Communications Commission, many were concerned that his lobbyist past and membership in the National Cable and Telecommunications Association would shift net neutrality in the direction of big corporate internet providers. What happened was a strong support for the American consumer. Zoom forward two years and net neutrality is once again up for debate as a new administration makes moves to threaten access. How can changes in net neutrality impact small business?

  • Internet Service Providers (ISPs) may have the ability to limit the speeds of the internet based on websites or apps frequented.
  • IPSs may be able to charge each website for data prioritization, which would give increased speeds while browsing that site.

Still puzzled about how shifts in net neutrality could impact you? Think of it this way, on the school playground thereâ€™s always a big, threatening kid who bullies the other smaller kids into giving over their lunches, paying for his snacks or some other egregious â€˜feeâ€™ for simply breathing in his space. ISPs, if left to their own devices, may become like those playground bullies, charging small businesses exorbitant fees just to play in the same playground as everyone else.

Worse yet, because your mom only gives you enough money to buy lunch but some kids have lunch money and an allowance, the playing field shifts further because they can afford to pay more for better access to the playground.

Net neutrality means that your small business gets the same internet speeds and access as Target, Walmart and your local diner. It's fair and equal for all. Loss of net neutrality will cost your business in lost marketing opportunities, a tightened sales pipeline and less access and online sales.

Leave a Reply

Named "Small Business Accountant of the Year"

Get business financial confidence now

- Avoid shoebox accounting and learn to manage your numbers.

- Learn how to get confidence in selecting a great accountant!

<|endoftext|>Fibromyalgia and Sleep

Home >> Sleep Disorders Problems >> Fibromyalgia and Sleep

Fibromyalgia is a medical syndrome that causes widespread pain and stiffness in the muscles and joints as well as sleep problems and chronic daytime fatigue. According to the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health, between 80 and 90% of people diagnosed with fibromyalgia are middle-aged women, although it can affect both sexes and people of all ages. Fibromyalgia is a confusing and often misunderstood condition. In the past, people who sought treatment for fibromyalgia symptoms were frequently told that their symptoms were "all in the head" and that they did not represent any known disease. However, in recent decades medical studies have proven that fibromyalgia does indeed exist, and that it is estimated to affect between 2% and 6% of people worldwide.

For people with fibromyalgia, the combination of pain and sleep disturbance is a double-edged sword: the pain makes sleep more difficult and sleep deprivation exacerbates pain. The good news is that reduction in sleep disturbance is usually followed by improvement in pain symptoms. This also highlights the importance of healthy sleep and to find a sleep professional in treating this disease.

Medical researchers have long sought to clarify the association between sleep disturbance and pain. Very little is known but a few key findings indicate that sleep and pain are intricately linked. For example, studies of patients experiencing pain after surgery show disturbed sleep, reduced rapid eye movement (REM) sleep, and a normalization of sleep as recovery proceeds. People with fibromyalgia may also experience an alteration in their patterns of slow wave sleep, which is the deepest stage of sleep. In one study , researchers selectively deprived a group of healthy middle-aged women of slow wave sleep for a period of three days. In response, the women showed a decreased tolerance for pain and increased levels of discomfort and fatigue, suggesting that


A. Peter Brannigan

The first applicant, Mr Peter Brannigan, was born in 1964. He is a labourer and lives in Downpatrick, Northern Ireland. He was arrested at his home by police officers on 9 January 1989 at 6.30 a.m. pursuant to section 12 (1) (b) of the Prevention of Terrorism (Temporary Provisions) Act 1984 (“the 1984 Act“). He was then removed to the Interrogation Centre at Gough Barracks, Armagh, where he was served with a copy of the “Notice to Persons in Police Custody“ which informs the prisoner of his legal rights (see paragraph 24 below). A two-day extension of his detention was granted by the Secretary of State on 10 January 1989 at 7.30 p.m., and a further three-day extension was granted on 12 January 1989 at 9.32 p.m.<|endoftext|> to win as evidenced by his impressive record but in Metamoris he had a different mindset. Saying that I want to say that I personally appreciate good defence as much as offence (I thought the Ryron Gracie vs. Andre Galvao match from Metamoris I was superb) however, there are different types of defence - and running away isn't one that's pleasing for the spectators eyes. I do agree maybe Cyborg could have done more to chase Schaub down and try to force him to engage but nevertheless, when your opponent enters the mat with no intention of winning, then it's difficult to make an exciting match.

Canadian Bear said...

"If your opponent is making it difficult for you to win - well what the hell did you expect?"

You must have Canadian in you :-) The irony/humour is outstanding.

Troy Beacleay said...

I almost always agree with you Doc, but this time I must disagree. There's a difference between not wanting to fight my fight and simply running away with no interest in fighting at all. I'm not saying he has to play in Cyborg's guard, but he has to play something. The problem is compounded by the fact that this wasn't some amateur tournament. These guys were getting paid, because I subscribed to the broadcast and paid them. If I pay my money, you better fight. If you want to play standup, fine. If you want to play ground, fine. I don't care which. Just try something. I'm not sure if you watched the Brendan Schaub match, but he clearly had no interest in engaging in any facet of a fight whatsoever. That's not going to fly and if they want to keep the Metamoris promotion afloat, they would do well to make sure that nonsense doesn't happen again.

Dr. AnnMaria said...

As far as what someone "has to do" I've always believed that they have to play within the rules, no more, no less. If the referee isn't looking, you still can't cheat, it's wrong. On the other hand, if there is not a rule against it, you are allowed to do it. I don't know what the rules are for the Metamoris promotion but since he did not get penalized, I am assuming he didn't break any. Yes he DID make it difficult for his opponent to win. You're saying they should change the rules to make it a more exciting sport for spectators. That is a different point. My point is if you play within the current rules (not some future rules), that is all you are required to do and people who then argue you made it hard for your opponent to win - like that's a bad thing - are pretty funny.

Troy Beacleay said...

Actually, he didn't make it difficult for his opponent to win in the slightest. It was a much easier victory than if his opponent had broken a sweat. I don't think there was any dissenting opinion over who won, nor was it close. And while no Metamoris rule was broken, that I'm aware of, it's dishonorable to ask for a fight and then get paid for a fight when you never had any intention of actually fighting in any way. If your mindset is, "I cannot let this person touch me in any way, anywhere", perhaps you should have challenged him to chess. If you want to fight, there's going to have to be some contact somewhere, sometime. According to Ralek's recent comments, I think he's in agreement that it was bad for his promotion.

Sylver said...

But he didn't make it difficult to win. As a matter of fact, he gave the win away.

He made it difficult to fight.

And in a fight, fighting is kind of the point, no?

Al B Here said...

It's nice to see that I wasn't the only one who held the opinion that Schaub was running the entire time. You're right, there was no explicit rule against running for 20 minutes, which is precisely what he did, but it does against the spirit of the competition. It was meant to be a test of skill. Schaub exhibited an ability to occasionally sprawl, yes, but he also spent a considerable amount of time on the "warning track" which, as others have pointed out, prevented Cyborg from driving his way to a takedown. If he had actively engaged, I would have a lot of respect for him. He didn't.

Anonymous said...

'Alan who complained that Brendan Schaub's match was "disrespectful" and that it was hard for his opponent...'

Schaub was disrespectful. Not in that he made it hard for Cyborg to win, but he refused to engage in a contest - anywhere, on the ground OR standing - when the audience had paid good money to see a competition.<|endoftext|>We gratefully acknowledge support from
the Simons Foundation and member institutions.
Full-text links:

Current browse context:

Change to browse by:

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(what is this?)

Physics > Plasma Physics

Title: Estimation of direct laser acceleration in laser wakefield accelerators using particle-in-cell simulations

Abstract: Many current laser wakefield acceleration (LWFA) experiments are carried out in a regime where the laser pulse length is on the order of or longer than the wake wavelength and where ionization injection is employed to inject electrons into the wake. In these experiments, the trapped electrons will co-propagate with the longitudinal wakefield and the transverse laser field. In this scenario, the electrons can gain a significant amount of energy from both the direct laser acceleration (DLA) mechanism as well as the usual LWFA mechanism. Particle-in-cell (PIC) codes are frequently used to discern the relative contribution of these two mechanisms. However, if the longitudinal resolution used in the PIC simulations is inadequate, it can produce numerical heating that can overestimate the transverse motion, which is important in determining the energy gain due to DLA. We have therefore carried out a systematic study of this LWFA regime by varying the longitudinal resolution of PIC simulations from the standard, best-practice resolution of 30 points per laser wavelength to four times that value and then examining the energy gain characteristics of both the highest-energy electrons and the bulk electrons. By calculating the contribution of DLA to the final energies of the electrons produced from the LWFA, we find that although the transverse momentum and oscillation radii are over-estimated in the lower-resolution simulations, this over-estimation does not lead to artificial energy gain by DLA. Rather, the DLA contribution to the highest-energy electrons is larger in the higher-resolution cases because the DLA resonance is better maintained. Thus, even at the highest longitudinal resolutions, DLA contributes a significant portion of the energy gained by the highest-energy electrons and also contributes to accelerating the bulk of the charge in the electron beam produced by the LWFA.
Comments: 12 pages. 5 figures
Subjects: Plasma Physics (physics.plasm-ph)
DOI: 10.1088/0741-3335/58/3/034008
Cite as: arXiv:1509.07921 [physics.plasm-ph]
  (or arXiv:1509.07921v1 [physics.plasm-ph] for this version)

Submission history

From: Jessica Shaw [view email]
[v1] Fri, 25 Sep 2015 23:26:22 GMT (1924kb)

Link back to: arXiv, form interface, contact.<|endoftext|>Friday, May 17, 2013

The Devil made me do it!

One of the things I despised as a fundamentalist Christian was how some of my fellow believers and evangelists blamed everything on the devil. My partner in the ministry was one of those types of believers. He blamed the devil for everything from epilepsy to homosexuality, to natural urges such as lust and even "normal" sexual desires. He viewed women that dressed "too provocatively" as immoral instruments of Satan to draw men away from God through distracting them through sexual lusts and desires.

Since God hates women I thank the devil for women like Rosario Dawson!

Sick people today love to use either God or the Devil as scapegoats for the crimes they commit against their own children, husbands, wives, family members, or society. They claim to hear voices in their heads telling them to kill such and such. This is not the result of demons or devils or God for that matter. It is more than likely that the person suffers from multiple personality disorders, schizophrenia, psychotic breaks and delusions.

New York's infamous David Ber

 to win as evidenced by his impressive record but in Metamoris he had a different mindset. Saying that I want to say that I personally appreciate good defence as much as offence (I thought the Ryron Gracie vs. Andre Galvao match from Metamoris I was superb) however, there are different types of defence - and running away isn't one that's pleasing for the spectators eyes. I do agree maybe Cyborg could have done more to chase Schaub down and try to force him to engage but nevertheless, when your opponent enters the mat with no intention of winning, then it's difficult to make an exciting match.

Canadian Bear said...

"If your opponent is making it difficult for you to win - well what the hell did you expect?"

You must have Canadian in you :-) The irony/humour is outstanding.

Troy Beacleay said...

I almost always agree with you Doc, but this time I must disagree. There's a difference between not wanting to fight my fight and simply running away with no interest in fighting at all. I'm not saying he has to play in Cyborg's guard, but he has to play something. The problem is compounded by the fact that this wasn't some amateur tournament. These guys were getting paid, because I subscribed to the broadcast and paid them. If I pay my money, you better fight. If you want to play standup, fine. If you want to play ground, fine. I don't care which. Just try something. I'm not sure if you watched the Brendan Schaub match, but he clearly had no interest in engaging in any facet of a fight whatsoever. That's not going to fly and if they want to keep the Metamoris promotion afloat, they would do well to make sure that nonsense doesn't happen again.

Dr. AnnMaria said...

As far as what someone "has to do" I've always believed that they have to play within the rules, no more, no less. If the referee isn't looking, you still can't cheat, it's wrong. On the other hand, if there is not a rule against it, you are allowed to do it. I don't know what the rules are for the Metamoris promotion but since he did not get penalized, I am assuming he didn't break any. Yes he DID make it difficult for his opponent to win. You're saying they should change the rules to make it a more exciting sport for spectators. That is a different point. My point is if you play within the current rules (not some future rules), that is all you are required to do and people who then argue you made it hard for your opponent to win - like that's a bad thing - are pretty funny.

Troy Beacleay said...

Actually, he didn't make it difficult for his opponent to win in the slightest. It was a much easier victory than if his opponent had broken a sweat. I don't think there was any dissenting opinion over who won, nor was it close. And while no Metamoris rule was broken, that I'm aware of, it's dishonorable to ask for a fight and then get paid for a fight when you never had any intention of actually fighting in any way. If your mindset is, "I cannot let this person touch me in any way, anywhere", perhaps you should have challenged him to chess. If you want to fight, there's going to have to be some contact somewhere, sometime. According to Ralek's recent comments, I think he's in agreement that it was bad for his promotion.

Sylver said...

But he didn't make it difficult to win. As a matter of fact, he gave the win away.

He made it difficult to fight.

And in a fight, fighting is kind of the point, no?

Al B Here said...

It's nice to see that I wasn't the only one who held the opinion that Schaub was running the entire time. You're right, there was no explicit rule against running for 20 minutes, which is precisely what he did, but it does against the spirit of the competition. It was meant to be a test of skill. Schaub exhibited an ability to occasionally sprawl, yes, but he also spent a considerable amount of time on the "warning track" which, as others have pointed out, prevented Cyborg from driving his way to a takedown. If he had actively engaged, I would have a lot of respect for him. He didn't.

Anonymous said...

'Alan who complained that Brendan Schaub's match was "disrespectful" and that it was hard for his opponent...'

Schaub was disrespectful. Not in that he made it hard for Cyborg to win, but he refused to engage in a contest - anywhere, on the ground OR standing - when the audience had paid good money to see a competition.<|endoftext|>We gratefully acknowledge support from
the Simons Foundation and member institutions.
Full-text links:

Current browse context:

Change to browse by:

References & Citations

(what is this?)

Physics > Plasma Physics

Title: Estimation of direct laser acceleration in laser wakefield accelerators using particle-in-cell simulations

Abstract: Many current laser wakefield acceleration (LWFA) experiments are carried out in a regime where the laser pulse length is on the order of or longer than the wake wavelength and where ionization injection is employed to inject electrons into the wake. In these experiments, the trapped electrons will co-propagate with the longitudinal wakefield and the transverse laser field. In this scenario, the electrons can gain a significant amount of energy from both the direct laser acceleration (DLA) mechanism as well as the usual LWFA mechanism. Particle-in-cell (PIC) codes are frequently used to discern the relative contribution of these two mechanisms. However, if the longitudinal resolution used in the PIC simulations is inadequate, it can produce numerical heating that can overestimate the transverse motion, which is important in determining the energy gain due to DLA. We have therefore carried out a systematic study of this LWFA regime by varying the longitudinal resolution of PIC simulations from the standard, best-practice resolution of 30 points per laser wavelength to four times that value and then examining the energy gain characteristics of both the highest-energy electrons and the bulk electrons. By calculating the contribution of DLA to the final energies of the electrons produced from the LWFA, we find that although the transverse momentum and oscillation radii are over-estimated in the lower-resolution simulations, this over-estimation does not lead to artificial energy gain by DLA. Rather, the DLA contribution to the highest-energy electrons is larger in the higher-resolution cases because the DLA resonance is better maintained. Thus, even at the highest longitudinal resolutions, DLA contributes a significant portion of the energy gained by the highest-energy electrons and also contributes to accelerating the bulk of the charge in the electron beam produced by the LWFA.
Comments: 12 pages. 5 figures
Subjects: Plasma Physics (physics.plasm-ph)
DOI: 10.1088/0741-3335/58/3/034008
Cite as: arXiv:1509.07921 [physics.plasm-ph]
  (or arXiv:1509.07921v1 [physics.plasm-ph] for this version)

Submission history

From: Jessica Shaw [view email]
[v1] Fri, 25 Sep 2015 23:26:22 GMT (1924kb)

Link back to: arXiv, form interface, contact.<|endoftext|>Friday, May 17, 2013

The Devil made me do it!

One of the things I despised as a fundamentalist Christian was how some of my fellow believers and evangelists blamed everything on the devil. My partner in the ministry was one of those types of believers. He blamed the devil for everything from epilepsy to homosexuality, to natural urges such as lust and even "normal" sexual desires. He viewed women that dressed "too provocatively" as immoral instruments of Satan to draw men away from God through distracting them through sexual lusts and desires.

Since God hates women I thank the devil for women like Rosario Dawson!

Sick people today love to use either God or the Devil as scapegoats for the crimes they commit against their own children, husbands, wives, family members, or society. They claim to hear voices in their heads telling them to kill such and such. This is not the result of demons or devils or God for that matter. It is more than likely that the person suffers from multiple personality disorders, schizophrenia, psychotic breaks and delusions.

New York's infamous David Berkowitz aka the Son of Sam.

David Berkowitz was a serial killer who began his spree in the summer of 1976 and which lasted a little over a year. He was also known as the 44 caliber killer because his crimes consisted of shooting people with a 44 calibre pistol. He claimed that he received his orders from a demon that had possessed his neighbors dog! Fortunately after he was captured and sentenced he was given six consecutive life sentences, so luckily for us we wont be seeing him in the local supermarket anytime soon.

Today I was watching a Spanish television realityy court show where two people were seeking a divorce after 27 years of marriage because they found out that both their adult kids were gay! Mom could not take it because she was religious and dad could not take it because he was an ignorant discriminating asshole who is still stuck in the bronze ages. As experts there was presented a reverend, a psychiatrist,


John Henry Hubley was born in 1948 and lives in Leeds. His wife died on 19 March 1997. The couple had two children, born in 1981 and 1984 respectively. In May 2000 John Henry Hubley enquired about widow’s benefits. On 17 May 2000 the Benefits Agency informed him that there was at that time no legislation providing an equivalent of the widows’ benefits concerned to widowers.<|endoftext|> him.

Suddenly, at a signal imperceptible to Nic, Nachancán stiffened. With the same stealth that had impressed Nic the day before, he reached over his shoulder and drew an arrow from his quiver. Through the trees Nic could see the other men crouched in similar positions, readying their weapons. He peered through the jungle twilight, but couldn’t tell what they were watching. There was a moment of absolute silence, even the birds and insects stilled, then a blur of brown through the green of the trees. Arrows flashed through the air and the deer fell. Yelling in triumph, the Mayans ran forward. Nic lagged behind, using the back of his hand to wipe the tears from his eyes. That’s all I need, he thought, for these macho men to see me crying like a girl.

By the time he reached the deer, the men had used the sharp flint knives strapped to their waists to slit it open and cut off its head. As Nic watched, they hung the deer’s head, stomach and liver from the branch of the nearest tree, then sat in a circle around the carcass and began to sing a prayer. Nic sat too, but couldn’t follow the words. His mind felt slow and clumsy, unable to process the sensory overload, the smells, the blood and the chanting. He tried to summon up a memory from his own life, something comforting and familiar to balance the foreignness of this culture, but the knowledge that he might never be able to return to that life blotted out all other thought.

The other men paid no attention to him as they continued with their prayers. Flies gathered on the hanging entrails and the disemboweled deer. Nic felt sick, but tried to clear his head and focus. He had to find the amulet before the next full moon, if he was to have any chance of going home.

His thoughts returned to Itzel, as always, and then to the girl he had just met, Ixchel. The two had to be related—the resemblance was too strong. Was it a coincidence that she was to be sacrificed at the full moon? He remembered the day José had come to him in despair and told him his theory about Itzel’s hereditary illness. A female ancestor was supposed to be sacrificed, and that sacrifice was never carried out, so the gods were angry. . . he refused to believe it. It was one thing to believe in magic and psychic connections and another to believe that a group of wrathful gods was bent on wreaking vengeance on one family down through time. He shook his head. There had to be another explanation.

He must find a way to talk further to Ixchel. Maybe she would know something about the amulet. Maybe she even had it, if she was to be. . . sacrificed. Even the word made him flinch. He had to save her somehow—he couldn’t allow an innocent young girl to go to her death, cultural differences or no cultural differences.

The chanting continued. Some of the men stood up and begun to dance around the bloody carcass. No one took any notice of Nic, seated quietly beside Nachancán. Maybe he could slip away and look for Ixchel? He decided against it. Better not to draw attention to himself.

Another thought occurred to him. If Itzel and Malinali still had the amulet, wouldn’t that mean that the sacrifice hadn’t taken place? Nic had to admit that part of José’s theory made sense, even if he didn’t believe the angry gods explanation. If Ixchel was Itzel’s ancestor, he wouldn’t have to do anything to keep her from being sacrificed—something else would happen to thwart it. On the other hand, maybe Ixchel had nothing to do with Malinali’s family. He felt paralyzed with indecision.

The men had finished their prayers and were getting ready to leave. Nachancán took the entrails from the tree while others knelt and with their flint knives carved up the carcass into large chunks which they put into mesh bags. Nic stood around feeling uncomfortable. Finally they all set out for home.

In Search of the Big Golden Buddha

Our seedy little hotel has an interesting feature, a slot next to the door where you insert a plastic card to turn on the electricity. When you leave the room, since the card is attached to the room key, you’re forced to take it out of the slot, which turns off the electricity. It’s a pretty nifty way for the hotel to save money. It’s obvious they’ve seen us coming, wasteful American tourists with our energy-guzzling habits like leaving the AC on all day so the room will be cool when we return. There will be none of that here!

I guess even monks need 7-11.

I’m in the hallway outside my room, waiting for the more slothful members of our party to make their appearance. It’s actually more like a large landing, with heavy wooden chairs arranged around a coffee table. Several doors, adorned like mine with beautiful bare-breasted Thai maidens, open off this landing, and all of them have shoes, mostly sandals, arranged neatly outside them. People here take their shoes off before entering houses. Curiously, we have the same custom in Washington, though it’s a lot more complicated there, since it’s rarely warm enough to wear flip-flops as almost everyone here does. At home it requires tedious unlacing and unbuckling.

But I digress. My companions have finally emerged from their rooms, blinking like moles in the morning light, and we set out in search of breakfast, which we eat, naturally, al fresco, at a stand with plastic tables set up around it.

So good!

It’s almost lunchtime, and most of the tables are occupied by giggling schoolgirls dressed in little white blouses, knee-length plaid pleated skirts, ankle socks and black and white Oxfords. I figure there must be one giant school-uniform company, centrally located in Siberia maybe, that supplies schools all over the world. It’s the only reasonable explanation for why school uniforms are the same everywhere.

The food, a spicy soup, is delicious. We’re already sweating, since it’s about a hundred degrees, and the humidity feels like a hot wet blanket draped over us. The soup makes us sweat even more. Then my sister Linda’s flimsy chair buckles and she falls over backwards onto the cement, causing a minor sensation among the schoolgirls since she’s over six feet tall and blonde. She gamely picks herself up and dusts herself off, and we set off, full, hot and happy.

We take a boat ride down the broad, brown Chao Phraya river that curves lazily through central Bangkok.

East meets west

A nice breeze affords some respite from the crushing heat. The city’s a mix of middle-class neighborhoods, crowded shantytowns, opulent, gilded temples that sparkle in the sunlight, and elegant high-rise hotels.

After a while we get off the boat and walk through a touristy area with lots of stands selling souvenirs. Linda, Ellie and I are itching to buy some of the beautiful fabrics and carved wood, but Nick shakes his head and tells us we’ll find these same things for half the price in Chiang Mai, the northern city he’s been living in for the past year and a half.

Now it’s mid-afternoon and we’re hot, sweaty and tired, but Ellie drives us on unmercifully in search of a huge golden Buddha she saw when she visited Bangkok the year before. Traffic, consisting of cars, tuk-tuks and more motorcycles than I’ve ever seen at one time before, swirls around us as we wander the sunstruck streets looking for the phantom Buddha.

We visit a couple of temple complexes, little oases of green and quiet surrounded by gilded Oriental structures.

I think it needs a little more gold. . .

Signs caution us not to touch the monks or be taken in by false tour guides. There are lily ponds patrolled by frighteningly large koi, and tiny, emaciated cats lounging everywhere. Nick tells us that people who want to divest themselves of their kitties (meanies!) drop them off at the temples. The poor little things look dazed. I hope they’re alert enough not to fall into the lily ponds, where they’d scarcely make a mouthful for one of those monster fish.

We finally convince Ellie to abandon the search for the big golden Buddha—we’ll buy a postcard instead. And now, one of the delights of Asia is beckoning to us: the legendary fish spa! Little Thai women industriously scrub our hot, aching feet and calves, and then we experience the bliss of lowering them into tanks of deliciously cool water with hundreds of tiny fish in it. The fish gather around and begin to nibble

 him.

Suddenly, at a signal imperceptible to Nic, Nachancán stiffened. With the same stealth that had impressed Nic the day before, he reached over his shoulder and drew an arrow from his quiver. Through the trees Nic could see the other men crouched in similar positions, readying their weapons. He peered through the jungle twilight, but couldn’t tell what they were watching. There was a moment of absolute silence, even the birds and insects stilled, then a blur of brown through the green of the trees. Arrows flashed through the air and the deer fell. Yelling in triumph, the Mayans ran forward. Nic lagged behind, using the back of his hand to wipe the tears from his eyes. That’s all I need, he thought, for these macho men to see me crying like a girl.

By the time he reached the deer, the men had used the sharp flint knives strapped to their waists to slit it open and cut off its head. As Nic watched, they hung the deer’s head, stomach and liver from the branch of the nearest tree, then sat in a circle around the carcass and began to sing a prayer. Nic sat too, but couldn’t follow the words. His mind felt slow and clumsy, unable to process the sensory overload, the smells, the blood and the chanting. He tried to summon up a memory from his own life, something comforting and familiar to balance the foreignness of this culture, but the knowledge that he might never be able to return to that life blotted out all other thought.

The other men paid no attention to him as they continued with their prayers. Flies gathered on the hanging entrails and the disemboweled deer. Nic felt sick, but tried to clear his head and focus. He had to find the amulet before the next full moon, if he was to have any chance of going home.

His thoughts returned to Itzel, as always, and then to the girl he had just met, Ixchel. The two had to be related—the resemblance was too strong. Was it a coincidence that she was to be sacrificed at the full moon? He remembered the day José had come to him in despair and told him his theory about Itzel’s hereditary illness. A female ancestor was supposed to be sacrificed, and that sacrifice was never carried out, so the gods were angry. . . he refused to believe it. It was one thing to believe in magic and psychic connections and another to believe that a group of wrathful gods was bent on wreaking vengeance on one family down through time. He shook his head. There had to be another explanation.

He must find a way to talk further to Ixchel. Maybe she would know something about the amulet. Maybe she even had it, if she was to be. . . sacrificed. Even the word made him flinch. He had to save her somehow—he couldn’t allow an innocent young girl to go to her death, cultural differences or no cultural differences.

The chanting continued. Some of the men stood up and begun to dance around the bloody carcass. No one took any notice of Nic, seated quietly beside Nachancán. Maybe he could slip away and look for Ixchel? He decided against it. Better not to draw attention to himself.

Another thought occurred to him. If Itzel and Malinali still had the amulet, wouldn’t that mean that the sacrifice hadn’t taken place? Nic had to admit that part of José’s theory made sense, even if he didn’t believe the angry gods explanation. If Ixchel was Itzel’s ancestor, he wouldn’t have to do anything to keep her from being sacrificed—something else would happen to thwart it. On the other hand, maybe Ixchel had nothing to do with Malinali’s family. He felt paralyzed with indecision.

The men had finished their prayers and were getting ready to leave. Nachancán took the entrails from the tree while others knelt and with their flint knives carved up the carcass into large chunks which they put into mesh bags. Nic stood around feeling uncomfortable. Finally they all set out for home.

In Search of the Big Golden Buddha

Our seedy little hotel has an interesting feature, a slot next to the door where you insert a plastic card to turn on the electricity. When you leave the room, since the card is attached to the room key, you’re forced to take it out of the slot, which turns off the electricity. It’s a pretty nifty way for the hotel to save money. It’s obvious they’ve seen us coming, wasteful American tourists with our energy-guzzling habits like leaving the AC on all day so the room will be cool when we return. There will be none of that here!

I guess even monks need 7-11.

I’m in the hallway outside my room, waiting for the more slothful members of our party to make their appearance. It’s actually more like a large landing, with heavy wooden chairs arranged around a coffee table. Several doors, adorned like mine with beautiful bare-breasted Thai maidens, open off this landing, and all of them have shoes, mostly sandals, arranged neatly outside them. People here take their shoes off before entering houses. Curiously, we have the same custom in Washington, though it’s a lot more complicated there, since it’s rarely warm enough to wear flip-flops as almost everyone here does. At home it requires tedious unlacing and unbuckling.

But I digress. My companions have finally emerged from their rooms, blinking like moles in the morning light, and we set out in search of breakfast, which we eat, naturally, al fresco, at a stand with plastic tables set up around it.

So good!

It’s almost lunchtime, and most of the tables are occupied by giggling schoolgirls dressed in little white blouses, knee-length plaid pleated skirts, ankle socks and black and white Oxfords. I figure there must be one giant school-uniform company, centrally located in Siberia maybe, that supplies schools all over the world. It’s the only reasonable explanation for why school uniforms are the same everywhere.

The food, a spicy soup, is delicious. We’re already sweating, since it’s about a hundred degrees, and the humidity feels like a hot wet blanket draped over us. The soup makes us sweat even more. Then my sister Linda’s flimsy chair buckles and she falls over backwards onto the cement, causing a minor sensation among the schoolgirls since she’s over six feet tall and blonde. She gamely picks herself up and dusts herself off, and we set off, full, hot and happy.

We take a boat ride down the broad, brown Chao Phraya river that curves lazily through central Bangkok.

East meets west

A nice breeze affords some respite from the crushing heat. The city’s a mix of middle-class neighborhoods, crowded shantytowns, opulent, gilded temples that sparkle in the sunlight, and elegant high-rise hotels.

After a while we get off the boat and walk through a touristy area with lots of stands selling souvenirs. Linda, Ellie and I are itching to buy some of the beautiful fabrics and carved wood, but Nick shakes his head and tells us we’ll find these same things for half the price in Chiang Mai, the northern city he’s been living in for the past year and a half.

Now it’s mid-afternoon and we’re hot, sweaty and tired, but Ellie drives us on unmercifully in search of a huge golden Buddha she saw when she visited Bangkok the year before. Traffic, consisting of cars, tuk-tuks and more motorcycles than I’ve ever seen at one time before, swirls around us as we wander the sunstruck streets looking for the phantom Buddha.

We visit a couple of temple complexes, little oases of green and quiet surrounded by gilded Oriental structures.

I think it needs a little more gold. . .

Signs caution us not to touch the monks or be taken in by false tour guides. There are lily ponds patrolled by frighteningly large koi, and tiny, emaciated cats lounging everywhere. Nick tells us that people who want to divest themselves of their kitties (meanies!) drop them off at the temples. The poor little things look dazed. I hope they’re alert enough not to fall into the lily ponds, where they’d scarcely make a mouthful for one of those monster fish.

We finally convince Ellie to abandon the search for the big golden Buddha—we’ll buy a postcard instead. And now, one of the delights of Asia is beckoning to us: the legendary fish spa! Little Thai women industriously scrub our hot, aching feet and calves, and then we experience the bliss of lowering them into tanks of deliciously cool water with hundreds of tiny fish in it. The fish gather around and begin to nibble at our feet. It’s the strangest sensation, as if they had tiny teeth, but very pleasant.

Yummy! I get the red part!

I take a closer look at them, and realize they’re those tiny sucker fish that diligently work their way up and down the glass walls of aquariums eating the algae. Hmm. I’m thinking,


David Shireby was born in 1955 and lives in Sheffield. His wife died on 3 April 2001. His claim for widows’ benefits was made in June 2001. On 22 June 2001 David Shireby was informed that he was entitled to Widowed Parent’s Allowance (“WPA”). However, on 14 January 2002 he was informed that he was not entitled to a Bereavement Payment on the ground that the benefit did not exist at the time of David Shireby’s wife’s death.<|endoftext|> can also help individuals file amended forms if they make a mistake on their returns. The right tax consultant can identify what needs to be amended and work to minimize the impact on your financial situation.

Tax consultants can help taxpayers minimize their tax liabilities and take advantage of deductions. They can also advise on charitable giving and inheritance issues. They often have additional training in accounting and tax law than a standard tax preparer. Fees for their services vary depending on the scope of the work. Tax consultants can save their clients hundreds or even thousands of dollars.

A good tax consultant should have strong communication skills. A good tax consultant is able to incorporate new information and research into a tax strategy. Additionally, they should be able to relate well to their clients and ensure that they understand their tax strategy. Furthermore, a tax consultant should have good organizational skills. For example, being organized will help avoid misplacing files. Lastly, a good tax consultant should be well-versed in accounting, law, and taxation.

Postgraduate education can also help in this career field. Many tax consultants earn a Master of Science in Taxation, while many others pursue a Juris Doctor degree in taxation. The latter degree will provide a deeper understanding of tax law and allow them to practice as tax attorneys. Additionally, there are a number of professional designations for tax consultants, including Certified Public Accountant and Enrolled Agent.

Fees for tax consultants vary widely. Some charge a flat fee for their work, while others charge an hourly rate. Generally, fees range from $175 to $450 an hour. It is important to do your research and ask for referrals before selecting a tax consultant. Many tax consultants are members of professional organizations that provide continuing education and ethics guidelines.

The main responsibility of a tax consultant is to help their clients save money through tax preparation. They will interview their clients to gather information about their financial status and develop strategies to minimize their tax liabilities. They will also ensure that clients fulfill their obligations and comply with the law. It is important to hire a tax consultant with experience and a degree in taxation, and a qualified candidate will be more valuable.

A tax consultant’s salary depends on many factors, including the education and experience of the candidate. Although high school graduates can also be successful in the field, most tax consultants hold a bachelor’s or master’s degree in accounting or business. About one out of every eight tax consultants did not attend college, however.

Leave a Reply

Your email address will not be published.<|endoftext|>Cancer Cells

Characteristics, Vs normal cells, Types and Microscopy

Overview: Cancer and Cancer Cells

Essentially, cancer is a disease of mitosis. As such, it occurs when normal cells are transformed into cancerous cells and proliferate uncontrollably. Cancer cells, therefore, are normal cells whose genes (several genes) have been damaged/mutated which in turn cause the cell as a whole to respond differently to signals that control the lifespan of a normal cell.

Because they do not respond to signals/instructions that control the development and death of normal cells, cancer cells continue to grow and proliferate and even invade other parts of the body. In the process, some of the cancer cells end up forming tumors not only at the first region to be affected (lungs etc) but also result in secondary malignant growths away from the primary site (metastasis).

Some of the main characteristics of cancer cells that differentiate them from other normal cells include:

  • Abnormally shaped and significantly vary in size
  • Incapable of self-repair
  • Do not go through normal apoptosis
  • Do not perform normal cell functions (as is the case with specialized cells)

Causes of Cancer Cells

Before looking at some of the main characteristics of cancer cells in detail, it is worth understanding what causes cancer.

Basically, the transformation of a cell from normal to cancerous is caused by agents that are collectively known as carcinogens. On the other hand, such biological factors as viruses (e.g. HPV) have been shown to increase the risk of cancer in various parts of the body. Here, these initiating agents, which include carcinogens (e.g. radiations, UV light, food additives, various chemicals, and cigarette smoke, etc) and viruses transform normal cells by causing damage to DNA and thereby inducing mutations.

Normal cells, however, do not generally transform into cancer cells within a few days. This may happen gradually with exposure to the initiating agent. For instance, this may occur as a result of smoking cigarettes for several years. As the cells become exposed to this initiating agent, several genes may end up being damaged which in turn may not only affect cell functions, but also the cell cycle.

Depending on the impact of the carcinogen on the cell, the type of cancer that develops (from the cancerous cells) would be different from other types of cancer. For instance, while some of the tumors that develop may be benign; others may be more aggressive and rapidly spread to other parts of the body.

* While there are different types of cancer cells as there are cancers, they all share a number of characteristics.

Characteristics of Cancer Cells

Compared to Normal Cells

Irregular Shape

For the most part, normal cells adopt a specific, uniform cell shape once they differentiate. Depending on the cell, this may allow the cell to effectively perform their function in the body.

A good example of this is red blood cells that have a biconcave shape that allows them to carry red blood cells effectively. Cancer cells, on the other hand, are irregular in shape and misshapen with varying sizes. Given that they do not attach to each other as other normal cells do (in various tissues) they also appear as a chaotic collection of cells when viewed under the microscope.

The irregular shape of cancer cells has also been identified in the nucleus and nucleolus of cancer cells. For instance, whereas normal cells have a nucleus with a smooth appearance that is spherical in shape, the nucleus of cancer cells tends to be irregular with bulges (blebs). This irregularity is also evident on the nucleolus and may be divided into multiple nucleoli.

Normal cells in the body live within a certain period of time and then die. For instance, red blood cells have a lifespan of about 120 days after which they undergo senescence.

Through this process, aged red cells are cleared while new ones continue to be produced to transport oxygen around the body. Cells in the body (normal cells) are destroyed through a process known as apoptosis in the event that damage to parts of the cell (DNA, etc) cannot be repaired.

For cancer cells, such mechanisms as cell repair are defective which allows the cells to continue living through an indefinite number of population doubling. Moreover, cancer cells do not respond to signals that initiate apoptosis as is the case with normal cells, which allows them to continue proliferating both in vivo and in vitro.

For normal cells, each division is accompanied by the shortening of the telomeres (at the ends of the chromosomes). When these regions wear out, the cell eventually dies. For cancer cells, however, the length of this part of the cell is retained which allows the cells to continue dividing. A good example of this is the HeLa cell line belonging to a woman by the name Henrietta Lacks who died in 1951 of cervical cancer.

Altered metabolism

In order to produce the energy required to effectively perform their functions, normal cells need oxygen and sugar (glucose) among other requirements.

Transformed cells, however, have been shown to have lower growth requirements compared to normal cells. For instance, in a study where 3T3 fibroblasts were transformed using several viruses, their growth in culture was shown to be successful despite the lack of various serum growth factors.

Unlike normal cells, cancer cells have also been shown to be capable of producing their own growth factors that can also stimulate the proliferation of other cells in their surroundings.

In both glycolysis and the tricarboxylic acid cycle, studies have shown cancerous cells to poorly use oxygen for energy production. Instead, they have been shown to use more glucose (to as much as 10 times more than normal cells) for energy production. Here, the sugar is converted to lactic acid before being recycled in the liver.

In some cases, these cells have also been shown to behave like metabolic parasites in that they drain energy from the surrounding cells. This provides them with the energy required for proliferation. At the same time, it also causes the organism to experience fatigue.

Cancer Cells induce Angiogenesis

One of the other characteristics of cancerous cells is their vascularizing abilities. By producing angiogenic factors (TAF), cancer cells stimulate endothelium growth and thus stimulate the formation of new blood vessels.

This allows the cells to receive more nutrients (high amounts of glucose) required for proliferation and growth. While angiogenesis plays an important role in supplying cancer cells, it has also been shown to highly contribute to metastasis.

Based on a variety of studies, the density of microvessels has been shown to be higher in malignant cancers as compared to benign neoplasias. Using the new vessels, cancer cells are able to migrate to other parts of the body and cause the

 can also help individuals file amended forms if they make a mistake on their returns. The right tax consultant can identify what needs to be amended and work to minimize the impact on your financial situation.

Tax consultants can help taxpayers minimize their tax liabilities and take advantage of deductions. They can also advise on charitable giving and inheritance issues. They often have additional training in accounting and tax law than a standard tax preparer. Fees for their services vary depending on the scope of the work. Tax consultants can save their clients hundreds or even thousands of dollars.

A good tax consultant should have strong communication skills. A good tax consultant is able to incorporate new information and research into a tax strategy. Additionally, they should be able to relate well to their clients and ensure that they understand their tax strategy. Furthermore, a tax consultant should have good organizational skills. For example, being organized will help avoid misplacing files. Lastly, a good tax consultant should be well-versed in accounting, law, and taxation.

Postgraduate education can also help in this career field. Many tax consultants earn a Master of Science in Taxation, while many others pursue a Juris Doctor degree in taxation. The latter degree will provide a deeper understanding of tax law and allow them to practice as tax attorneys. Additionally, there are a number of professional designations for tax consultants, including Certified Public Accountant and Enrolled Agent.

Fees for tax consultants vary widely. Some charge a flat fee for their work, while others charge an hourly rate. Generally, fees range from $175 to $450 an hour. It is important to do your research and ask for referrals before selecting a tax consultant. Many tax consultants are members of professional organizations that provide continuing education and ethics guidelines.

The main responsibility of a tax consultant is to help their clients save money through tax preparation. They will interview their clients to gather information about their financial status and develop strategies to minimize their tax liabilities. They will also ensure that clients fulfill their obligations and comply with the law. It is important to hire a tax consultant with experience and a degree in taxation, and a qualified candidate will be more valuable.

A tax consultant’s salary depends on many factors, including the education and experience of the candidate. Although high school graduates can also be successful in the field, most tax consultants hold a bachelor’s or master’s degree in accounting or business. About one out of every eight tax consultants did not attend college, however.

Leave a Reply

Your email address will not be published.<|endoftext|>Cancer Cells

Characteristics, Vs normal cells, Types and Microscopy

Overview: Cancer and Cancer Cells

Essentially, cancer is a disease of mitosis. As such, it occurs when normal cells are transformed into cancerous cells and proliferate uncontrollably. Cancer cells, therefore, are normal cells whose genes (several genes) have been damaged/mutated which in turn cause the cell as a whole to respond differently to signals that control the lifespan of a normal cell.

Because they do not respond to signals/instructions that control the development and death of normal cells, cancer cells continue to grow and proliferate and even invade other parts of the body. In the process, some of the cancer cells end up forming tumors not only at the first region to be affected (lungs etc) but also result in secondary malignant growths away from the primary site (metastasis).

Some of the main characteristics of cancer cells that differentiate them from other normal cells include:

  • Abnormally shaped and significantly vary in size
  • Incapable of self-repair
  • Do not go through normal apoptosis
  • Do not perform normal cell functions (as is the case with specialized cells)

Causes of Cancer Cells

Before looking at some of the main characteristics of cancer cells in detail, it is worth understanding what causes cancer.

Basically, the transformation of a cell from normal to cancerous is caused by agents that are collectively known as carcinogens. On the other hand, such biological factors as viruses (e.g. HPV) have been shown to increase the risk of cancer in various parts of the body. Here, these initiating agents, which include carcinogens (e.g. radiations, UV light, food additives, various chemicals, and cigarette smoke, etc) and viruses transform normal cells by causing damage to DNA and thereby inducing mutations.

Normal cells, however, do not generally transform into cancer cells within a few days. This may happen gradually with exposure to the initiating agent. For instance, this may occur as a result of smoking cigarettes for several years. As the cells become exposed to this initiating agent, several genes may end up being damaged which in turn may not only affect cell functions, but also the cell cycle.

Depending on the impact of the carcinogen on the cell, the type of cancer that develops (from the cancerous cells) would be different from other types of cancer. For instance, while some of the tumors that develop may be benign; others may be more aggressive and rapidly spread to other parts of the body.

* While there are different types of cancer cells as there are cancers, they all share a number of characteristics.

Characteristics of Cancer Cells

Compared to Normal Cells

Irregular Shape

For the most part, normal cells adopt a specific, uniform cell shape once they differentiate. Depending on the cell, this may allow the cell to effectively perform their function in the body.

A good example of this is red blood cells that have a biconcave shape that allows them to carry red blood cells effectively. Cancer cells, on the other hand, are irregular in shape and misshapen with varying sizes. Given that they do not attach to each other as other normal cells do (in various tissues) they also appear as a chaotic collection of cells when viewed under the microscope.

The irregular shape of cancer cells has also been identified in the nucleus and nucleolus of cancer cells. For instance, whereas normal cells have a nucleus with a smooth appearance that is spherical in shape, the nucleus of cancer cells tends to be irregular with bulges (blebs). This irregularity is also evident on the nucleolus and may be divided into multiple nucleoli.

Normal cells in the body live within a certain period of time and then die. For instance, red blood cells have a lifespan of about 120 days after which they undergo senescence.

Through this process, aged red cells are cleared while new ones continue to be produced to transport oxygen around the body. Cells in the body (normal cells) are destroyed through a process known as apoptosis in the event that damage to parts of the cell (DNA, etc) cannot be repaired.

For cancer cells, such mechanisms as cell repair are defective which allows the cells to continue living through an indefinite number of population doubling. Moreover, cancer cells do not respond to signals that initiate apoptosis as is the case with normal cells, which allows them to continue proliferating both in vivo and in vitro.

For normal cells, each division is accompanied by the shortening of the telomeres (at the ends of the chromosomes). When these regions wear out, the cell eventually dies. For cancer cells, however, the length of this part of the cell is retained which allows the cells to continue dividing. A good example of this is the HeLa cell line belonging to a woman by the name Henrietta Lacks who died in 1951 of cervical cancer.

Altered metabolism

In order to produce the energy required to effectively perform their functions, normal cells need oxygen and sugar (glucose) among other requirements.

Transformed cells, however, have been shown to have lower growth requirements compared to normal cells. For instance, in a study where 3T3 fibroblasts were transformed using several viruses, their growth in culture was shown to be successful despite the lack of various serum growth factors.

Unlike normal cells, cancer cells have also been shown to be capable of producing their own growth factors that can also stimulate the proliferation of other cells in their surroundings.

In both glycolysis and the tricarboxylic acid cycle, studies have shown cancerous cells to poorly use oxygen for energy production. Instead, they have been shown to use more glucose (to as much as 10 times more than normal cells) for energy production. Here, the sugar is converted to lactic acid before being recycled in the liver.

In some cases, these cells have also been shown to behave like metabolic parasites in that they drain energy from the surrounding cells. This provides them with the energy required for proliferation. At the same time, it also causes the organism to experience fatigue.

Cancer Cells induce Angiogenesis

One of the other characteristics of cancerous cells is their vascularizing abilities. By producing angiogenic factors (TAF), cancer cells stimulate endothelium growth and thus stimulate the formation of new blood vessels.

This allows the cells to receive more nutrients (high amounts of glucose) required for proliferation and growth. While angiogenesis plays an important role in supplying cancer cells, it has also been shown to highly contribute to metastasis.

Based on a variety of studies, the density of microvessels has been shown to be higher in malignant cancers as compared to benign neoplasias. Using the new vessels, cancer cells are able to migrate to other parts of the body and cause the spread of cancer to these regions.

Adhesion (cell to cell adhesion and cell to extracellular matrix adhesion)

For normal cells, cell to cell adhesion and cell to extracellular matrix adhesion has been shown to play an important role in enhancing cell growth, differentiation, multiplication and function. Disruption of the same has been associated with motility of the cells as well as invasion through the extracellular matrix.

Compared to normal cells, cancer cells have been shown to be less adhesive due to loss of such surface adhesive molecules


manship on the part of one of your pickers.

3. Integrate New Technology

Pick-and-pack can really benefit from the most modern technology accessible. Since pick-and-pack requires orders to be logged and your staff to access them to fulfill the order, you’ll probably need a very good database and tracking system to see which orders are completed, by whom, and all other relevant information, like completion dates and client addresses. Many professionals recommend tablet technology since it’s mobile and easy to use with touch screens.

4. Improve Your Warehouse Layout

It’s important to have easy access to products so they can be picked and packed as soon as the orders are placed. Wading through disorganized bins of products or not arranging your workspace well only slows down the process, along with creating more than a few safety issues. If you have to perform warehouse and fulfillment center rearranging to make your pick process better, do it.

5. Use a Visual System

Experts have begun noting how well a visual system of categorizing and organizing products works. What this means is that you organize your products using colors or image tags so that you can access them according to their type, section, or brand. The advantages of this are twofold: you can keep track of numbers or order status through digital formats via visual media such as bar codes and you reduce worker stress. The latter is because text-based categorization fatigues workers more and can lead to an increase in processing issues.

6. Track Your Error Rates

With more technology and the option to keep tabs on pick-and-pack orders comes the ability to keep track of errors. Obviously you can’t make your pick path error free, but as you do your pick-and-pack services, you can spot error points as they arise and fix them quickly.

Note that a lot of newly reformed pick-and-pack companies have introduced rewards systems for employees who find and correct errors. From a management point of view, this might be a worthwhile program for your company as well. It’s not good to go fingerpointing when errors happen, but you can inspire better performance amongst your staff.

Correcting pick-and-pack errors just requires some effort, keen eyes, and the implementation of new tools or techniques. Once you’ve spotted the problems in your pick-and-pack process, you can sharpen your methods.
<|endoftext|>The Pain of Love

A lost, broken girl. Her life is shattered into pieces, her heart broken with some missing pieces. A popular, kind boy, he has everything anyone ever dreamt of. What happens when they collide? Will he be the one putting the shattered pieces together and mend the broken heart as well as go and find the missing pieces? Or will he be the one walking away, leaving her more broken than ever? A book of love, heartbreaks, and tears.
They say, leave your past the past, move on and maybe forget about it.

What happens when it comes back to haunt you?

2. Meeting Chris

We arrived at the shops not so long after, I followed Amanda in and then went to the drink aisle, I pulled open the fridge's door and grabbed the Sprite can, suddenly another hand came in and reached for the same one, we both pulled back,

" Sorry! " We both said in unison

" You take it, " the person said

" No, no, it's ok, you can " I replied, refusing to take it

Apparently, this person doesn't take 'no' for an answer, the person pushed the can into my hand, forcing me to take it. I held it in my hand as the individual reached for another can in the fridge. I looked at the persona nd realize, it was Chirs, the most popular boy in the school, plays basketball, or let say all kind of sports and sometimes skips class, richest boy in school and he's the son of the principal.

" Hey, you look familiar, have I seen you somewhere? " he asked, observing my face

" Uh... I don't think so..." I said

" Anyways, what's your name? "

"...Autumn..." I muttered I don't think he heard me though

" Nice name, I'm Chris by the way, soz gotta run, catch you later! " He said before running to pay his drink and head out of the store, turning around and wave at me before entering a black Lamborghini.

I smiled quietly and waved back before finding my way back to Amanda, on the way, I picked up some shaving cream and snacks for Jake. Once I found Amanda, she was holding a full basket of...stuff.

" Ah, there you are, where were you? " Amanda asked looking at me before turning back to try and pick out some potatoes.

" Drink aisle met Chris and grabbed a Sprite can. " I said before throwing the stuff in the basket and picked out some good looking potatoes and threw them in the plastic bag.

" Oh thanks, you've always been good with cooking and stuff. By the way, Chris was it? Isn't he the son of the principal at your school? " She asked

" Yeah, he is " I answered her as we went and paid for the stuff.

" Are you sure we need all these things? " I asked, looking at the worker as she scans the item looking bored.

" Duh, we have five people to feed! " She said, raising her eyebrows.

I nodded as we collected the bags and walked home. On our way home, I looked at the trees as leaves start to grow on them, despite how beautiful life is, I just... hate it...

" Hey, earth to Autumn, are listening?? " Amanda asked me, waving her hand over my eyes.

" Oh, sorry, what did you say? " I asked

" Are you joining any club this year? " She asked

I sigh, she asks me this question every year, and she already knows the answer, I don't get what is so fun about joining a club.

" You know the answer, Amanda, " I said, irritated

" Come on Autumn! You should at least join one this year! You have talents; you should show it! All you do is spend time in that stupid studio of yours! " Amanda exclaimed

" It's not stupid Amanda! " I said fiercely looking at her.

" I'm sorry, but you should at least join one! You are an amazing student! You get straight A's for everything, you are the best at sport in school, best in music, let say best in everything! You are better than everyone, but all you do is spend time in that hideous studio! What do you even do in there? " She asked.

" I live in there, Amanda, my life is in that studio. I'm who I am in that studio. " I replied looking at her.

" Um, ok..." She said as an awkward silent fell between us.

I looked at her then back at the road ahead. This year, I'll be in year 11, and I'll be teaching dance to year 7 and 8, ballet and contemporary that is. Then in summer break, I'll be teaching gymnastic to the primary school students. That's probably the only things I'm looking forward to, then I remembered, Chris is doing the same thing but with hip-hop and soccer. I sigh and imagine myself in the studio. I spent breaks there day and night; it's where I live pretty much I play music there like singing, cello, piano, guitar, violin, and dance as well. Then when everyone already left the school, I use the court to play basketball and the tracks to run. The school is my life, I feel the safest there, away from... that person.

We reached home and went inside, Amanda, and I placed the bags down on the table. Jake ran down and grabbed his stuff before running upstairs again, entering his room before slamming the door, making me jump a little.

" Jake! I'm coming up! " Amanda said before storming up the wooden stairs.

I laughed quietly to myself and placed everything in its place before walking upstairs, closing the door. I sat at the edge of the bed and put my hand on my forehead before falling onto the bed, my head, hitting the pillow. Soon, I drifted off to sleep, then, I heard whispers,

" You are ugly; you are worthless, you are unloved, a slut... Tell anyone about the past, and you will pay for it! "

I sat up quickly and looked around, I expected to see someone, but there was no one in my room. My forehead was covered in sweat, I lied down again and covered my eyes with my arm as tears started rolling down my cheeks, soaking the pillow...

Loading ...<|endoftext|>Kurt Nielsen is a Danish citizen, born in 1966. He resides in Skanderborg, Denmark. On 12 November 1986 Kurt Nielsen was involved in a car accident. He was severely injured and is now partly disabled. On 26 February 1988 Kurt Nielsen instituted proceedings against three insurance companies in the City Court of Skanderborg (retten i Skanderborg).<|endoftext|>Remote consultation by Zoom are available
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Drunk driving charges and employment

. It might be a matter of rearranging your step-by-step pick path or correcting faulty workmanship on the part of one of your pickers.

3. Integrate New Technology

Pick-and-pack can really benefit from the most modern technology accessible. Since pick-and-pack requires orders to be logged and your staff to access them to fulfill the order, you’ll probably need a very good database and tracking system to see which orders are completed, by whom, and all other relevant information, like completion dates and client addresses. Many professionals recommend tablet technology since it’s mobile and easy to use with touch screens.

4. Improve Your Warehouse Layout

It’s important to have easy access to products so they can be picked and packed as soon as the orders are placed. Wading through disorganized bins of products or not arranging your workspace well only slows down the process, along with creating more than a few safety issues. If you have to perform warehouse and fulfillment center rearranging to make your pick process better, do it.

5. Use a Visual System

Experts have begun noting how well a visual system of categorizing and organizing products works. What this means is that you organize your products using colors or image tags so that you can access them according to their type, section, or brand. The advantages of this are twofold: you can keep track of numbers or order status through digital formats via visual media such as bar codes and you reduce worker stress. The latter is because text-based categorization fatigues workers more and can lead to an increase in processing issues.

6. Track Your Error Rates

With more technology and the option to keep tabs on pick-and-pack orders comes the ability to keep track of errors. Obviously you can’t make your pick path error free, but as you do your pick-and-pack services, you can spot error points as they arise and fix them quickly.

Note that a lot of newly reformed pick-and-pack companies have introduced rewards systems for employees who find and correct errors. From a management point of view, this might be a worthwhile program for your company as well. It’s not good to go fingerpointing when errors happen, but you can inspire better performance amongst your staff.

Correcting pick-and-pack errors just requires some effort, keen eyes, and the implementation of new tools or techniques. Once you’ve spotted the problems in your pick-and-pack process, you can sharpen your methods.
<|endoftext|>The Pain of Love

A lost, broken girl. Her life is shattered into pieces, her heart broken with some missing pieces. A popular, kind boy, he has everything anyone ever dreamt of. What happens when they collide? Will he be the one putting the shattered pieces together and mend the broken heart as well as go and find the missing pieces? Or will he be the one walking away, leaving her more broken than ever? A book of love, heartbreaks, and tears.
They say, leave your past the past, move on and maybe forget about it.

What happens when it comes back to haunt you?

2. Meeting Chris

We arrived at the shops not so long after, I followed Amanda in and then went to the drink aisle, I pulled open the fridge's door and grabbed the Sprite can, suddenly another hand came in and reached for the same one, we both pulled back,

" Sorry! " We both said in unison

" You take it, " the person said

" No, no, it's ok, you can " I replied, refusing to take it

Apparently, this person doesn't take 'no' for an answer, the person pushed the can into my hand, forcing me to take it. I held it in my hand as the individual reached for another can in the fridge. I looked at the persona nd realize, it was Chirs, the most popular boy in the school, plays basketball, or let say all kind of sports and sometimes skips class, richest boy in school and he's the son of the principal.

" Hey, you look familiar, have I seen you somewhere? " he asked, observing my face

" Uh... I don't think so..." I said

" Anyways, what's your name? "

"...Autumn..." I muttered I don't think he heard me though

" Nice name, I'm Chris by the way, soz gotta run, catch you later! " He said before running to pay his drink and head out of the store, turning around and wave at me before entering a black Lamborghini.

I smiled quietly and waved back before finding my way back to Amanda, on the way, I picked up some shaving cream and snacks for Jake. Once I found Amanda, she was holding a full basket of...stuff.

" Ah, there you are, where were you? " Amanda asked looking at me before turning back to try and pick out some potatoes.

" Drink aisle met Chris and grabbed a Sprite can. " I said before throwing the stuff in the basket and picked out some good looking potatoes and threw them in the plastic bag.

" Oh thanks, you've always been good with cooking and stuff. By the way, Chris was it? Isn't he the son of the principal at your school? " She asked

" Yeah, he is " I answered her as we went and paid for the stuff.

" Are you sure we need all these things? " I asked, looking at the worker as she scans the item looking bored.

" Duh, we have five people to feed! " She said, raising her eyebrows.

I nodded as we collected the bags and walked home. On our way home, I looked at the trees as leaves start to grow on them, despite how beautiful life is, I just... hate it...

" Hey, earth to Autumn, are listening?? " Amanda asked me, waving her hand over my eyes.

" Oh, sorry, what did you say? " I asked

" Are you joining any club this year? " She asked

I sigh, she asks me this question every year, and she already knows the answer, I don't get what is so fun about joining a club.

" You know the answer, Amanda, " I said, irritated

" Come on Autumn! You should at least join one this year! You have talents; you should show it! All you do is spend time in that stupid studio of yours! " Amanda exclaimed

" It's not stupid Amanda! " I said fiercely looking at her.

" I'm sorry, but you should at least join one! You are an amazing student! You get straight A's for everything, you are the best at sport in school, best in music, let say best in everything! You are better than everyone, but all you do is spend time in that hideous studio! What do you even do in there? " She asked.

" I live in there, Amanda, my life is in that studio. I'm who I am in that studio. " I replied looking at her.

" Um, ok..." She said as an awkward silent fell between us.

I looked at her then back at the road ahead. This year, I'll be in year 11, and I'll be teaching dance to year 7 and 8, ballet and contemporary that is. Then in summer break, I'll be teaching gymnastic to the primary school students. That's probably the only things I'm looking forward to, then I remembered, Chris is doing the same thing but with hip-hop and soccer. I sigh and imagine myself in the studio. I spent breaks there day and night; it's where I live pretty much I play music there like singing, cello, piano, guitar, violin, and dance as well. Then when everyone already left the school, I use the court to play basketball and the tracks to run. The school is my life, I feel the safest there, away from... that person.

We reached home and went inside, Amanda, and I placed the bags down on the table. Jake ran down and grabbed his stuff before running upstairs again, entering his room before slamming the door, making me jump a little.

" Jake! I'm coming up! " Amanda said before storming up the wooden stairs.

I laughed quietly to myself and placed everything in its place before walking upstairs, closing the door. I sat at the edge of the bed and put my hand on my forehead before falling onto the bed, my head, hitting the pillow. Soon, I drifted off to sleep, then, I heard whispers,

" You are ugly; you are worthless, you are unloved, a slut... Tell anyone about the past, and you will pay for it! "

I sat up quickly and looked around, I expected to see someone, but there was no one in my room. My forehead was covered in sweat, I lied down again and covered my eyes with my arm as tears started rolling down my cheeks, soaking the pillow...

Loading ...<|endoftext|>Remote consultation by Zoom are available
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  3. Uncategorized
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Drunk driving charges and employment

On Behalf of | Jul 4, 2017 | Uncategorized

A person who is convicted or charged with driving under the influence of alcohol in Louisiana faces serious consequences. These are not just legal consequences either. The effects can spread to include employment