Using Nc1ncnc(O)c1N, COC(=O)C12CCC(c3ccc(C(=O)C(C)(C)Br)cc3)(CC1)CC2 to produce COC(=O)C12CCC(c3ccc(C4=Nc5c(N)ncnc5OC4(C)C)cc3)(CC1)CC2, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.