Using O=C(c1ncc(Br)cc1C(F)(F)F)C(O)O, Nc1nccc(Nc2ccc(C(F)(F)F)cn2)c1N to produce FC(F)(F)c1ccc(Nc2ccnc3nc(-c4ncc(Br)cc4C(F)(F)F)cnc23)nc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.