Using C#CCOC, COc1cc2ncc(C#N)c(Nc3cc(Br)cc4c3OCO4)c2cc1OC to produce COCC#Cc1cc(Nc2c(C#N)cnc3cc(OC)c(OC)cc23)c2c(c1)OCO2, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.