Using CCOC(=O)c1ccc(-c2c(F)c(OC)cc(OC)c2F)c2nccnc12 to produce COc1cc(OC)c(F)c(-c2ccc(C(=O)O)c3nccnc23)c1F, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.