Using COC(=O)C1CCOc2cc(Oc3ccc(C(=O)Nc4cccc(C(F)(F)F)c4)cc3)c(C#N)cc21 to produce N#Cc1cc2c(cc1Oc1ccc(C(=O)Nc3cccc(C(F)(F)F)c3)cc1)OCCC2C(=O)O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.