Using c1cncc(B2OCCCO2)c1, COc1ccc(CNc2ncc(C#N)c3sc4cc(Br)ccc4c23)cc1 to produce COc1ccc(CNc2ncc(C#N)c3sc4cc(-c5cccnc5)ccc4c23)cc1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.