Using O=C1CSC(NCc2cccs2)=N1, CCOc1nc(NC)nc2ccc(C=O)cc12 to produce CCOc1nc(NC)nc2ccc(C=C3SC(NCc4cccs4)=NC3=O)cc12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.