Using O=C(O)c1ccc(Br)cc1F, COc1ccc2c(OCCn3nc(Cl)ccc3=O)ccnc2c1 to produce COc1ccc2c(OCCn3nc(-c4ccc(C(=O)O)c(F)c4)ccc3=O)ccnc2c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.