Using COC(=O)c1ccc2c(c1)[nH]c1ncnc(N3CCOC(CNC(=O)OC(C)(C)C)C3)c12 to produce CC(C)(C)OC(=O)NCC1CN(c2ncnc3[nH]c4cc(C(=O)O)ccc4c23)CCO1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.