Using COc1cccc2c(=O)[nH]nc(Cc3ccc(F)c(C(=O)O)c3)c12, COC1CCNCC1 to produce COc1cccc2c(=O)[nH]nc(Cc3ccc(F)c(C(=O)N4CCC(OC)CC4)c3)c12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.