Using CCc1coc(-c2ccc(O)c(OC)c2)n1, CCOC(=O)C[C@@H]1CCc2cc(OCCCBr)ccc21 to produce CCOC(=O)C[C@@H]1CCc2cc(OCCCOc3ccc(-c4nc(CC)co4)cc3OC)ccc21, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.