Using COC(=O)c1cccc2cc(Nc3ncnc4cc(OC)c(OC)cc34)ccc12 to produce COc1cc2ncnc(Nc3ccc4c(C(=O)O)cccc4c3)c2cc1OC, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.