Using COCC[C@H](C)N=C=S, Nc1ccc(-c2nc(C3CC3)[nH]c2-c2ccc(F)cc2F)nc1O to produce COCC[C@H](C)Nc1nc2ccc(-c3nc(C4CC4)[nH]c3-c3ccc(F)cc3F)nc2o1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.