Using CCOC(=O)c1c(C)nc2c(O)cccn12, Fc1cncc(F)c1CCl to produce CCOC(=O)c1c(C)nc2c(OCc3c(F)cncc3F)cccn12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.