Using Cn1cc(-c2ncc(-c3ccc4cc(O)ccc4c3)o2)c2ccccc21, COC(=O)CBr to produce COC(=O)COc1ccc2cc(-c3cnc(-c4cn(C)c5ccccc45)o3)ccc2c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.