Using COC(=O)[C@H](Cc1cc(Cl)c(OCc2cccc3nc(-c4ccccc4)oc23)c(Cl)c1)NC(=O)C(F)(F)F to produce N[C@@H](Cc1cc(Cl)c(OCc2cccc3nc(-c4ccccc4)oc23)c(Cl)c1)C(=O)O, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.