Using COC(=O)c1nc(C#N)c(-c2ccccn2)c2cc(OC)ccc12 to produce COc1ccc2c(C(=O)O)nc(C#N)c(-c3ccccn3)c2c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.