Using O=c1cc(N2CCOCC2)nc2n1CC[C@@H](C(F)(F)F)N2, COc1cccc(CCl)c1 to produce COc1cccc(CN2c3nc(N4CCOCC4)cc(=O)n3CC[C@H]2C(F)(F)F)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.