Using COC1(OC)CCCO1, Cc1c(N2CC[C@H](N)C2)c(F)cn2c(=O)c(C(=O)O)cc(C3CC3)c12 to produce Cc1c(N2CC[C@H](n3cccc3)C2)c(F)cn2c(=O)c(C(=O)O)cc(C3CC3)c12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.