Using COC(=O)c1cn(-c2ccnc3cc(OC)ccc23)c2ccccc12 to produce COc1ccc2c(-n3cc(C(=O)O)c4ccccc43)ccnc2c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.