Using O=C(O)c1ccc(N2CCOCC2)cc1, COc1cnc(N2CCOCC2)c2sc(N)nc12 to produce COc1cnc(N2CCOCC2)c2sc(NC(=O)c3ccc(N4CCOCC4)cc3)nc12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.