Using COC(=O)c1ccc2nc(N3CCC(c4ccc(OC)cc4)CC3)c(-c3ccc(F)cc3)nc2c1 to produce COc1ccc(C2CCN(c3nc4ccc(C(=O)O)cc4nc3-c3ccc(F)cc3)CC2)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.