Using COc1ncnc2sc(N=C(SC)SC)nc12, NC[C@]1(O)CN2CCC1CC2 to produce COc1ncnc2sc(NC3=NC[C@@]4(CN5CCC4CC5)O3)nc12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.