Using c1ccc2c(c1)c(C1CCNCC1)cn2CC1CC1, COC(=O)c1cccc(CBr)c1 to produce O=C(O)c1cccc(CN2CCC(c3cn(CC4CC4)c4ccccc34)CC2)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.