Using COCCBr, CC(C)(O)c1ccc(-c2cc(C(N)=O)c(Nc3cccc(CO)n3)s2)c(F)c1 to produce COCCOCc1cccc(Nc2sc(-c3ccc(C(C)(C)O)cc3F)cc2C(N)=O)n1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.