Using C#CCOC, COc1cc2ncc(C#N)c(Nc3c(Cl)cc(I)c4c3OCO4)c2cc1OC to produce COCC#Cc1cc(Cl)c(Nc2c(C#N)cnc3cc(OC)c(OC)cc23)c2c1OCO2, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.