Using COc1cc(Nc2c(C#N)cnc3cc4cc(OCc5ccccc5)c(OC)cc4cc23)c(Cl)cc1F to produce COc1cc2cc3c(Nc4cc(OC)c(F)cc4Cl)c(C#N)cnc3cc2cc1O, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.