Using C1CCOC1, O=C(NCc1ccc(C(F)(F)F)cc1)Nc1cccc2c(Cl)nccc12 to produce O=C(NCc1ccc(C(F)(F)F)cc1)Nc1cccc2c(O)nccc12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.