Using COC(=O)c1c[nH]c2cc(Cl)c(-c3ccc(C4CCN(C(C)=O)CC4)cc3)cc12 to produce CC(=O)N1CCC(c2ccc(-c3cc4c(C(=O)O)c[nH]c4cc3Cl)cc2)CC1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.