Using O=C(O)C(F)(F)F, COc1ccc(C(=O)Nc2c(C#N)cnn2C)c2sc(N3CCNCC3)nc12 to produce COc1ccc(C(=O)Nc2c(C#N)cnn2C)c2sc(N3CCN(C)CC3)nc12, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.