Using O=C(O)c1cnccn1, COc1ccc(Nc2nc(N3CCC(N)C3)nc3scnc23)cc1OC to produce COc1ccc(Nc2nc(N3CCC(NC(=O)c4cnccn4)C3)nc3scnc23)cc1OC, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.