Using COc1cccc2c1CCN1C(=O)CNC(=O)C=C21, CC(C)c1c[nH]cn1 to produce COc1cccc2c1CCN1C(=O)CN=C(n3cnc(C(C)C)c3)C=C21, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.