Using Brc1nccs1, NCCN1CCC(Nc2nc3ccccc3n2Cc2ccco2)CC1 to produce c1coc(Cn2c(NC3CCN(CCNc4nccs4)CC3)nc3ccccc32)c1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.