Using COc1ccc([C@@H](C)N2C[C@H]([C@H](C)O)CC2=O)cc1, N#Cc1cnn2cc(Cl)nc(O)c12 to produce COc1ccc([C@@H](C)N2C[C@H]([C@@H](C)Oc3nc(Cl)cn4ncc(C#N)c34)CC2=O)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.