Using COC(=O)c1cn2nc(N)nc2c(-c2cccc(C(F)(F)F)c2)c1C to produce Cc1c(C(=O)O)cn2nc(N)nc2c1-c1cccc(C(F)(F)F)c1, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.