Using COC(=O)c1ccc(CN2CC=C(c3cc4c(-c5cc(F)ccc5OC)ncnc4[nH]3)CC2)cc1 to produce COc1ccc(F)cc1-c1ncnc2[nH]c(C3=CCN(Cc4ccc(C(=O)O)cc4)CC3)cc12, please predict the solvent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.