Using COC(=O)c1ccc2nc(-c3ccccc3)c(N3CCN(c4ccc(OC)cc4)CC3)nc2c1 to produce COc1ccc(N2CCN(c3nc4cc(C(=O)O)ccc4nc3-c3ccccc3)CC2)cc1, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.