Using Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2[nH]ncc2c1, COC(=O)CBr to produce COC(=O)Cn1ncc2cc(-c3cc(C(=O)NC4CC4)cc(F)c3C)ccc21, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.