Using O=C(O)C(F)(F)F, Cc1c([C@H]2CN3CCNC[C@@H]3CO2)ccc(F)c1C#N to produce COc1ccc([C@H]2CN3CCNC[C@@H]3CO2)c(C)c1C#N, please predict the agent for this reaction in SMILES notation in \boxed{$SMILES1, SMILES2, ...} format.