THE PHARMACOLOGICAL ACTIVITY OF SUCCINATECONTAINING HEPATOPROTECTORS IN EXPERIMENTAL LIVER DAMAGE
The results of Researches on the effectiveness of succinatecontainingmedicians(reambe rin, remaxol and runihol) in experimental drug liver damage caused by 14-day introduction of the essentials anti-TB drugs, as well as their impact on the processes of reparative regeneration of the liver in experimental partial resection are presented. It is established that the studied medicianscontribute to the normalization of indicators of protein-lipid metabolism and normalize the activity of enzymes of cytolysis and cholestasis, increase the level of endogenous SAM in hepatocytes. In parallel, registered normalization of histological picture of the liver: restoration of cytoarchitectonic, reducing the manifestations of malnutrition and necrobiosis (except for the group of animals treated by runihol).Remaxoland runihol accelerated the recovery of liver mass, while the maximum positive effect remaxol marked on the 4th, and the runihol - on the 14th day after surgery. The obtained data indicate the presence of the studied drugs hepatoprotective properties.