ROLE OF MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS IN RECURRENT MISCARRIAGE
Objective. To carry out a systematic analysis of the data available in the modern literature on the role of major histocompatibility complex antigens in recurrent miscarriage, preterm delivery, fetal growth retardation, and preeclampsia. Subject and methods. The review included the data of foreign and Russian articles given in Pubmed on this topic and published in the past 15 years. Results. This review sets forth the present-day idea on the contribution of the marital HLA system (killer cell immunoglobulin-like receptors (KIRs), HLA-C antigens, HLA compatibility, and anti-HLA antibodies) to recurrent miscarriage, and other obstetric complications (preterm delivery, fetal growth retardation, and preeclampsia) associated with inadequate placentation. Conclusion. To understand the role of the HLA system during successful pregnancy and its complications, there is a need for further investigations, including a study of associations between recurrent miscarriage and specific maternal alleles, coincidences in HLA alleles in married couples, as well as for analysis of gene polymorphisms and a molecular interaction between KIRs and HLA-C molecules.