PROSPECTS OF OBTAINING NEW FILM MATERIALS BASED ON ALGINATE-CHITOSAN INTERPOLIMER COMPLEX FOR BIOMEDICAL APPLICATION
The possibility and the optimal conditions for obtaining membranes based on alginate-chitosan interpolyelectrolyte complex (IPEC ALNa-СT) were investigated. The film compositions were prepared by mixing solutions of sodium alginate and chitosan with a concentration of 5 g-l·l with an equimolar ratio of the components. The volatile weak base (an aqueous solution of ammonia) was used as a solvent for IPEC. Films were prepared by irrigation on an inert substrate followed by drying at constant humidity and room temperature. The possibility of using the resulting membranes as carriers of drugs was studied. The antibiotic of vast gamma of antibacterial action such as Levomycetin was introduced into the polymer composition in the form of an alcohol solution (at the stage of molding). The dynamics of its release from the obtained membranes based on IPEC ALNa- CT at various pH 5.8-8.5, modeling the physiological environments of the human body, was studied. It was shown that in most cases, the release rate of an antibiotic from the biopolymer membranes based on IPEC ALNa-CT is independent of the pH value. For all samples, antibiotic release occurs within 4 hours and is 40-60 %. Such duration allows the drug to be delivered evenly, and opens up prospects for using the obtained films based on IPEC-based ALNa-CT for the development of asustained-release wound dressing containing antibiotics.