THE PATHOGENETIC NUANCES OF CHRONIC ENDOMETRITIS (LITERATURE REVIEW)
The review adduces the information about the ability of some infectious agents not only to initiate a chronic inflammation in the endometrium, but also to intervene in the mechanisms of apoptosis of the host cells. It is noted that the defective endometrial growth is a critical factor adjustable by different expression of the genes controlling the cell cycle and determining the loss of early pregnancy. The role of apoptosis in the normal functioning of the endometrium is confirmed by the data about hormone conditioned cyclic activity changes of the main regulator of this process (bcl-2) in the epithelium of endometrial glands. A particular interest is represented the information that cytokine imbalance disrupts the synthesis of steroid sulfatase, degradation enzyme systems, in turn, starts a local hyperestrogenia, realized in excessive proliferation of the endometrium. It is indicated that the declared informational importance of evaluative and prognostic predictors of the disorders of the universal adaptive mechanisms in response to chronic inflammation determines the effectiveness of pathogenetic stratification.