CLINICAL-RADIOLOGICAL AND LABORATORY ASPECTS OF HYPERPROLACTINAEMIA SYNDROME OF THE CENTRAL AND PERIPHERAL GENESIS
594 women of reproductive age with hyperprolactinaemia and menstrual dysfunction and\or infertility were examined. According to Magnetic resonance imaging (МРI) changes in hypophysis area were established at 199 women (33,5 %), adenomas of a hypophysis at 109 of them and in 80,8 % of cases - microadenoma. The most frequent non-tumoral processes were endokraniosis (39 %) and changes connected with intracranial pressure (29,7 %). In the anamnesis of patients with non-tumoral processes near hypophysis the frequency of prenatal complications (40,6 %) and craniocereberal injuries (15,6 %) was high. Women with a central genesis of hyperprolactinaemia had Prolactinum in 7,6 times more, with symptomatic hyperprolactinaemia in 2,9 times more than women with the regular two-phase menstrual cycle. Patients with a central genesis of hyperprolactinaemia had more pronounced clinical picture and Prolactinum in 2,6 times more than patients with a peripheral genesis of hyperprolactinaemia. Hyperprolactinaemia hypogonadism developed at level of Prolactinum more than 4000 mI.U.\l.