Influence of hepatoprotective agents of phospholipids structure on liver bioenergetics and lipoperoxidation in experimental liver pathology caused by paracetamol
Influence of hepatoprotective agents of phospholipids structure essentiale, eplir and its combinations with amber acid on rats liver functional state, lipoperoxidation and bioenergetics in experimental paracetamol intoxication was investigated. These agents demonstrated antioxidant action, decreased the common and indirect bilirubine blood content, aminotransferase and alkaline phosphatase activity. Paracetamol uncoupled the substrate oxidation with ADP phosphorylation and inhibited the respiratory activity of liver mitochondrions. Essentiale and eplir increased the coupling of oxidation with ATP synthesis, in combination with amber acid improved kinetic characteristics of liver mitochondrions.