Fluoroquinolones Drug Delivery Systmes: New Perspective in Tuberculosis Treatment
The review focuses on new delivery systems of fluoroquinolones, highly active antibiotics, which application in therapy is still limited due to low bioavailability and low solubility in biological media. The development of suitable delivery systems seems to be a promising solution to these problems. Here we consider the delivery systems based on synthetic polymers (polylactic and polyglycolic acids and their copolymers, polycaprolactones etc.) and natural polymers, in particular polysaccharides. Ol igosaccharide delivery systems, conjugates of fluoroquinolones with natural polymers, as well as lipid delivery systems, including liposomes, solid lipid particles and hybrid particles are also discussed. The characteristic features of oral, intravenous and aerosol delivery methods for fluoroquinolones have been revealed, which is especially important in the development of new drugs for the treatment of tuberculosis. Keywords: drug delivery systems, fluoroqunolones, tuberculosis