THE INFLUENCE OF THERAPY WITH ZOFENOPRIL ON THE REMODULATION AND DIASTOLIC FUNCTION OF LEFT VENTRICLE IN PATIENTS WITH HYPERTENSION DISEASE
For the purpose of studying the action of therapy with zofenopril on the remodulation of left ventricle (LV) and dynamics of life quality parameters in patients with hypertension disease (HD), 52 patients with HD at the II stage were included in the research. 25 patients received zofenopril, 27 patients - enalapril. At the beginning of the study the V and VII types of remodulation of LV were observed. In 6 months the desired level of AP was achieved in all patients. The patients were observed the decrease of SIVT, TBSLV, LVMM, LVIMI (p<0,05), a number of patients with LV hypertrophy has been reduced to 40%, the diastolic function has been improved. After normalization of LVIMI, 36% of the patients had 2nd type of remodulation, the diastolic function was normalized. The improvement of life quality parameters was revealed in the majority of patients (p<0,05). Thus, zofenopril causes favorable action on the remodulation processes of LV, leading to improvement of hypertensive patients ' life quality.