CHOICE OF STATISTICAL APPROACHES AND ANALYSIS OF BLOOD SERUM PROTEOMA PROFILES IN AN EXPERIMENT WITH 24-HOUR HEAD-DOWN TILT (-15°)
Variability analysis of normal human proteoma requires a valid and crisp algorithm for mass-spectrometry data analysis. The goal was to test methods of statistical analysis of blood serum proteoma profiles in an experiment with 24-hr. HOT using the small sample nonparametric criteria. The investigation revealed peaks that appear to be a molecular response of organism to simulated microgravity. Further identification of fiducially mobile peaks with the help of tandem mass-spectrometry will enable disclosure of subtle mechanisms of adaptation to the spaceflight factors and improvement of human health evaluation in space missions of varying length.