Reversible diadenosine tetraphosphate intercalation into Mg/Al-layered double hydroxides nanoparticles
Preparation of Ap<sub>4</sub>A intercalateted into nanodimensional (100-200 nm) Mg/Al-layered double hydroxides (LDH) particles has been originally obtained. The intercalation has been shown not to alter Ap<sub>4</sub>A chemical structure. Parameters of Ap<sub>4</sub>A deintercalation from the nanoparticles first have been studied. It has been established that the release rate of Ap<sub>4</sub>A from the nanohybrid is obviously depend on pH (the release rate at pH 7.5 is remarkable lower than that at 4.4) and the buffer ionic composition. The results obtained show the possibility of LDH/Ap<sub>4</sub>A nanoparticles using as pH-controlled passive system of Ap<sub>4</sub>A drug delivery to the target cells.