Role of a base in ensuring the bioavailability of naproxen suppositories
In vitro and in vivo experiments were carried out to investigate the bioavailability of naproxen depending on the type of a suppository base and surfactants. Biopharmaceutically rational excipients were chosen. The advantage of Witepsol H-15 over solid confectionary fat in producing the analgesic effect of naproxen suppositories was shown on laboratory animals.