The Role of Hyperuricemia in Human Morbidity, and Treatment Options
Objective of the Review: To analyze up-to-date information about hyperuricemia (HU). Key Points: Hyperuricemia is caused by reduced excretion of uric acid (UA), its increased production, or a combination of these factors. A number of disorders also contribute to HU, including obesity, metabolic syndrome, reduced renal function, alcohol abuse, and intake of acetyl salicylic acid or diuretics. HU, in turn, is a marker of several metabolic disorders, atherosclerosis, and cardiovascular and kidney diseases. Normalization of UA levels is a promising way to reduce risk of cardiovascular and cerebrovascular events and worsening of renal insufficiency. Conclusion: Hyperuricemia may be viewed as a new target of preventive therapy for renal, cardiac, and vascular disorders. Its treatment can improve quality of life and increase survival.