STUDY OF INFLUENCE OF COMPLEX POLIFENOLS FROM GRAPES CULTURAL ON BACKGROUND OF THE EXPERIMENTAL EKSAYTOTOXICITY CAUSED BY MONOSODIUM GLUTAMATE
The paper presents the results of a study of activity the complex polifenols from grapes cultural background of the experimental exsaytotoxicity caused by monosodium glutamate in rats. It has been established that glutamate exsaytotoxicity is characterized by significant impairments in functional activity of the central nervous system, the development of oxidative stress and pathological hormonal changes. Introduction to the diet of concentrate the complex polifenols from grapes in a dose of 90 mg/kg reduced the manifestations of exsaytotoxicity. All the studied parameters of the central nervous system: research locomotor activity, autonomic reactions were in the range of physiological norm. The complex polifenols from grapes introduced on background of the experimental exsaytotoxicity caused by monosodium glutamate contributed normalization prooxidant-antioxidant balance and contributed reduction corticosterone level.