STUDY ON SYSTEMIC INFLAMMATION ACTIVITY IN PATIENTS WITH OBESITY-ASSOCIATED OSTEOARTHRITIS
A comparative analysis on the content of proinflammatory cytokines in different weight patients with osteoarthritis was conducted. Patients with osteoarthritis and obesity were found to have significantly higher levels of proinflammatory cytokines (IL-1β, IL-6 and TNF-α) in comparison to patients with normal body weight. 6 months treatment with chondroitin sulfate and glucosamine hydrochloride provides reduction in proinflammatory cytokines to levels of control in patients with normal body weight, while patients with obesity preserve abnormal markers.