GLUTATHIONE SYSTEM OF INTERNAL ORGANS IN THE PRESENCE OF MULTIPLE SKELETAL TRAUMA IN EXPERIMENT – ROLE OF EPINEPHRINE AND DEXAMETHASONE
The experiment involving Chinchilla rabbits simulated multiple skeletal trauma in conditions of general anaesthesia. In postoperative period on the background of standard treatment, the first group of animals showed reduction of metabolic activity. For this reason, the second group of rabbits having the same conditions of multiple skeletal trauma simulation together with the standard treatment additionally received Epinephrine and Dexamethasone for correction of posttraumatic hypobiosis. Having studied the influence of Epinephrine and Dexamethasone on the system of glutathione of internal organs in animals of the second group, we marked the general tendency for increasing of reduced glutathione and decreasing of activity of glutathione peroxidase in heart, lungs, liver and kidneys. Decreased activity of glutathione peroxidase and glutathione reductase, that we revealed in lungs, weakened antioxidant protection and worked towards secondary injury.