STATE OF IMMUNE SYSTEM AFTER THREE MONTHS’ ExPOSURE WITH ENDOGENOUS NITROSOAMINE PRECURSORS
The objective of the work is to establish a dose-dependent changes in the immune system of animals after three months exposure of nitrosoamine precursors (sodium nitrite, tetracycline).It has been found that the isolated action of sodium nitrite leads to a decrease of natural killer cells, and it promotes lymphopenia and an increase in the relative number of neutrophils. By increasing the dose to 20 mg in addition to the oppression of non-specific defense factors it is observed the immunosuppression of T-and B-components of immunity, as well as the development of autosensibilization.Under the combined effects of the nitrosamines precursors immunological effects are characterized by induction of secondary immunodeficiency.The dose dependence was determined. In addition to reducing the number of blood cells and autosensibilization, there is the development of sensitization to haptens.Increasing the NA dose to 20 mg leads to a widening of the spectrum of the immunological effects - to increase the level of circulating immune complexes and the development of hypersensitivity of delayed type.