Lipid peroxidation processes and protective role of the Antioxidant system in liver and in erythrocytes in the case of acute blood loss
The mechanism of liver and erythron system interaction is not fully understood. This problem is considered in two aspects: firstly, the role of liver function in erythrocyte system; secondly, the disclosure of the pathogenesis of disorders of the red blood cells in liver lesions. In acute blood loss both the liver and erythrocytes have an important functional load. Therefore the study of their antioxidant system that performs a protective function is of great interest. The effect of acute blood loss on the performance of the «lipid peroxidation-antioxidant» system in the liver and erythrocytes was studied. Тhe work was done on white rats. The content of malondialdehyde and catalase activity in the liver and red blood cells and the activity of glutathione reductase in erythrocytes were studied. The total protein content and the percentage of protein fractions in blood serum were determined. It is shown that emerged hypoxia activates the processes of lipid peroxidation in hepatocytes and erythrocytes what is evidenced by an increase in their level of malondialdehyde. Simultaneously the activity of catalase in the liver and erythrocytes and antioxidant potential of blood serum are increasing. It can indicate activation of the antioxidant protective system.