Skin microcirculation reaction to acute hypotensive effects of various antihypertensive medications in hypertensive patients
Aim. To assess the dynamics of skin microcirculation (MC) in response to medications with different mechanisms of hypotensive action in patients with arterial hypertension (AH). material and methods. In patients with Stage 2-3 AH, MC was assessed by laser Doppler flowmetry at baseline and after a single administration of corinfar (n=38), capoten (n=37), and concor (n=37). Results. In patients with a clear hypotensive effect of the examined medications, the dynamics of skin MC parameters was similar. The reorganisation of peripheral hemodynamics was characterised by dysbalanced and insufficiently effective regulatory processes and restricted reserves of capillary blood flow. The increase in tissue perfusion was due to the increased pulse filling of MC vessels. Conclusion. Similar dynamics of MC parameters in response to the administration of medications with different hypotensive mechanisms suggests that an acute drop in peripheral vascular resistance leads to an urgent adaptive reaction aimed at the maintenance of adequate capillary-tissue metabolism.