EFFECTIVENESS OF RONKOLEIKIN PREPARATION AS VACCINE ADJUVANT AGAINST PARVOVIRUS INFECTION IN DOGS
The aim of the study was to compare different vaccination schemes for puppies against parvovirus enteritis of dogs by using vaccines of domestic and foreign origin. The most optimal vaccination scheme for puppies, which is most effective, has been developed. The first vaccination of puppies should be done at the age of 10-14 weeks, when the level of maternal antibodies is decreased to 6.0 log2 in RTGA, with the obligatory inclusion of the immunomodulating Roncoleikin preparation, aimed to maintain high antibody titer in the post-vaccination period. The analysis of the level of antibodies in the blood serum of puppies of different breeds as regards the causative agent of parvovirus infection in dogs has been carried out. It is shown that the level of antibody growth against parvovirus enteritis in dogs during vaccination depends largely on the presence of maternal antibodies.