Morphological Structural Changes of Lamina Cribrosa in Experimental Animals after Application of Atropine Sulphate in Low Doses
Introduction. A description of the results of the study of morphological changes in the structures of the eyeball in experimental animals after the use of atropine sulfate in small doses is absent in the scientific medical literature. Purpose. To analyze the morphological features of the membranes and eyes, especially the sclera and the cribriform plate after applying atropine sulfate instillations of 0.5% and 0.01% in experimental animals (rabbits). Materials and methods. In the experiment, 42 rabbits 84 eyes at the age of 5 months, weighing 2.5 kg chinchilla breed were studied. Which were observed in the experiment for 6 months. Depending on the concentration of atropine sulfate used, the rabbits were divided into 2 study groups: group 1 (atropine sulfate concentration 0.5%) 19 rabbits 38 eyes. And group 2 (atropin sulfate concentration of 0.01%) was 17 animals 34 eyes. In the control group there were 8 animals 16 eyes. During the experiment, the morphological state of the membranes in the region of the posterior pole of the eye and the cribriform plate was appreciated. Results. As a result of the study, it was found that in the area of the posterior pole of the eye in animals of the studied group, compared with the control group, thickening of the fibrous membrane of the eye is observed, the thickness of the sclera increases significantly, the thickness of the lattice plate and the wall of the pores significantly increase the intensity of collagen type I and III . The morphofunctional state of the retina does not change. Conclusions. Comparing the studied groups, it was established that the use of 0.01% atropine sulfate concentration in order to stabilize the morphological changes in the membranes of the eye in the posterior pole was established.