SUBCLINICAL ENDOMETRIOSIS-ASSOCIATED COAGULOPATHY AND ITS RELATIONSHIP WITH INDICATORS OF THE GENERAL ANALYSIS OF BLOOD
Objective. To compare coagulogram parameters in patients with endometrioid ovarian cysts and patients with corpus luteum cysts before and after surgery, as well as to determine whether there are correlations between coagulogram parameters and general blood test in the investigated groups. Methods. The study included patients with ovarian cysts: 45 women with a histologically verified diagnosis of "endometrioid ovarian cyst" and 39 women with a histologically verified diagnosis of "corpus luteum cyst" (comparison group). Retrospectively, the following parameters were recorded in the case histories: coagulogram and general blood analysis before and after radical surgical treatment, followed by statistical analysis of the data. Results. The prothrombin index in the endometriosis group is significantly higher before surgery and significantly decreases after radical removal of endometrioid ovarian heterotopia. Prothrombin time, on the contrary, in the presence of an endometrioid ovarian cyst is significantly less than in the comparison group, and increases after its radical removal. The levels of fibrinogen and fibrin did not significantly differ either between the investigated groups before and after surgery. Despite the fact that in patients of both groups the coagulogram parameters are not beyond the normal values, in patients with a corpus luteum cyst no significant changes in the coagulogram were detected after operation. Based on the statistical analysis of coagulogram parameters and their relationship with other hematological parameters in the groups, the formation of a hypercoagulation state in ovarian endometriosis (which is absent in the comparison group) is clearly seen, associated with the systemic influence of heterotopia, which forms an environment favorable for it. Conclusion. Endometriosis is a pathology that has a multifaceted systemic effect on the body and, in particular, on the blood clotting system. Together with a significant increase in the number of platelets in this pathology and the dependence of this phenomenon on the mononuclear phagocyte system, which supports the homeostasis of endometrioid heterotopia, a tendency to hypercoagulation of subclinical endometriosis-associated coagulopathy is formed, which may be an unfavorable background for the development of other intercurrent pathologies.