DETERMINATION OF QUANTUM-CHEMICAL FUNDAMENTALS OF PHARMACOKINETIC PROPERTIES OF A NEW PHARMACEUTICAL COMPOSITION
Quantum-chemical calculations have shown that carbamazepine, caffeine, and 2,4-dichlorobenzoic acid do not interact, components of the mixture are transported separately in biological liquids: 2,4-dichlorobenzoic acid and caffeine are transported in the dissolved state, and carbamazepine is transported in the complex with the serum albumin. Components of the mixture are not in competition for the bonding with caffeine and do not decrease the bioavailability of each other.