CHARACTERISTICS OF THE IMMUNE SYSTEM RECOVERY SYNDROME IN PATIENTS WITH CO-INFECTION (TB / HIV)
In 2019-2020, in the Udmurt Republic, as well as in the Russian Federation as a whole, there is a decrease in the morbidity and mortality of the population from tuberculosis, as well as changes in some other indicators indicating an improvement in the epidemic situation for tuberculosis. Against the background of the improvement of some epidemic indicators in the majority of the territories of the Udmurt Republic, negative trends persist towards the further growth of drug-resistant forms of tuberculosis, combined infectious lesions of HIV/tuberculosis among patients newly identified and registered in anti-tuberculosis institutions, which indicates a heavier contingent of phthisiological patients and largely determines the lack of effectiveness of their treatment. At present, when the accumulated knowledge and ideas about HIV infection have been formed into a separate scientific discipline, it is possible and necessary to study in more depth certain specific issues of this disease. Since the introduction of three-component antiretroviral therapy (ART) in 1996, and due to significant improvements in diagnostic capabilities (including for the detection of opportunistic infections), there have been reports in the literature about a syndrome that develops against the background of immune recovery, which has been called «immune reconstitution inflammatory syndrome» (IRIS). IRIS - the development or progression of the tuberculosis process in the first months from the beginning/resumption of ART, which is based on the restoration of an active immune response. This study examines the immune recovery syndrome that developed as a result of treatment of tuberculosis in combination with HIV infection on the basis of one of the departments of the tuberculosis hospital of the city of Izhevsk in 2018-2020. And also the factors of occurrence of this syndrome, its manifestations are studied. Drug therapy of the underlying disease and treatment of the inflammatory syndrome were studied.