HISTOTOPOGRAPHY AND DYNAMICS OF INDICATORS OF THE VASCULAR BED OF THE HEMATIC ACINUS IN THE CONDITIONS OF MULTIPLE ETHANOL INTOXICATION
The liver is a vital organ. The polyfunctionality of the liver in evolution was formed in such a way that even in the physiological norm, the functioning of the organ proceeds under conditions of elevated concentrations of toxic substances. One of the hepatotoxicants is ethanol, which is not a foreign agent to the liver. The analysis of the results of histotopography and the dynamics of indicators of the vascular bed of the structural and metabolic unit of the liver - hepatic acini was carried out. With the use of morphological methods, an increase in the venous level of the hepatic acini in the portal tract and the lumen of the sinusoidal capillaries of the perivenular and centrolobular zones was observed over a period of 15 days. Using the method of electron microscopy, changes in the bulk density of the nucleus, nucleolus and lipids were determined throughout the experiment. On the part of the cellular composition of the blood of animals, inhibition of cellular and humoral immunity is noted, which gradually recovers from acute experience by the third day, a persistent decrease in erythrocyte volume indices and their hemoglobin content, as well as in platelet heterogeneity, an increase in total white blood cells, which indicates stress in response to the action of ethanol intoxication in a multiple mode.