The prevention of postnatal endometriosis in puerperae with different degree of infection risk with implementation of application form of sorbent agent
The first stage of study included determination of risk factors of postnatal pyo-septic complications and development of scale of evaluation of degree of infection risk. The second stage of study included implementation of cohort, prospective, randomized research. The sampling included 176 puerperae with infection risk. The observed women were separated on groups depending on degree of infection risk according the developed scale. The puerperae of comparison group received common antibacterial prevention by cephalosporin of third generation. The puerperae of main group during postnatal period besides prevention with antibiotics, were additionally injected into uterine cavity a contact-type form of sorbent VNIITU-1. The effectiveness of prevention was evaluated by determination of the level of proinflammatory and anti-inflammatory cytokines in aspirate from uterine cavity at first and third day and occurrence of growth of pathogenic flora. In puerperae of comparison group after common antibiotic prevention, growth of pathogenic flora in uterine cavity persisted. This process contributed into increasing of activity of local proinflammatory cytokines (IL-1β), acute-phase protein lactoferrin against the background of decreasing of activity of anti-inflammatory cytokines (IL-10, IL-RAIL). It also testified high activity of local macrophages and absence of tendency of suppression of inflammatory cascade. The proposed mode of prevention of postnatal endometriosis in puerperae with infection risk by intrauterine injection of porous carbonic applicator VNIITU-1 is more effective due to stimulation of full value elimination of agents and their excreted toxins from uterine cavity. Additionally, blocking of local proinflammatory cascade and intensification of involutorial processes of myometrium against the background of restoration of hemodynamics occurs.