ANALYSIS OF VENLAFAXINE IN BLOOD BY THIN LAYER CHROMATOGRAPHY AND UV SPECTROPHOTOMETRY METHODS
The method of venlafaxine isolation from the blood by liquid-liquid extraction with chloroform at pH 7-8 has been developed. The blood cell precipitation was carried out by 10 % trichloroacetic acid solution, back extraction and TLC purification was used for removing the coextracted biological ma- trix components. Analysis of venlafaxine in the extracts was performed by TLC and UV spectrophoto- metry. The efficiency of the isolation method developed was 36 ± 3 %.