GENETIC PREDISPOSITION TO DEVELOPMENT OF PULMONARY DISEASES IN CHILDREN
Using polymerase chain reaction we studied genetic polymorphism Tyr113His in the gene of microsomal epoxide hydrolase in 73 children with community-acquired pneumonia. These children were in hospital and went through inpatient care in 2010-2011. The control group consisted of 12 healthy children. During the study it was found out that in 63.7% of the cases children with pneumonia had functionally impaired genotype. Among children with community-acquired pneumonia, complicated with bronchoobstructive syndrome, genotype Tyr/Tyr was 2.5 times more often than among children who had a pneumonia without bronchoobstructive syndrome. Tyr allele of polymorphism Tyr113His in the gene of microsomal epoxide hydrolase occurs in patients with bronchoobstructive syndrome quite often. The obtained data confirm the facts of genetically determined predisposition to the clinical course of pulmonary diseases in children.