AUGMENTIN ES - THE DRUG WITH THE ADVANCED PHARMACOKINETICS
The present article is concerned with inhibitor-protected antibiotic Amoxicillin/Klavulanat (Augmentin) with high efficiency in the treatment of infections of respiratory tract, soft tissues and urinary system. Currently, the most preparations of Amoxicillin/Klavulanat were developed with component ratio 4: 1, however experimental and clinical researches have shown benefits of "advanced" preparations with higher component ratio, in particular 16: 1 (Augmentin XR) and 14: 1 - a pediatric syrup Augmentin ES. It was shown that Augmentin ES is effective in the treatment of acute otitis media, particularly in otitis caused by pneumococci with the decreased sensitivity, as well as caused by β-lactamase - producing H. influenzae and M. catarrhalis. The preparation is effective in the treatment of acute bacterial sinusitis caused by the same flora, and in the treatment of other infections, for example caused by staphilococci with higher minimal inhibitory concentration in relation to Amoxicillin.