Effectiveness of Treatment of Mycosis of the Feet with Topical Antimycotics Various Pharmacological Groups
Analysis of the literature data and the results of the author's own studies indicate that sertaconazole (Zalain) is a highly active, antifungal drug of broad spectrum with fungicidal, antibacterial, anti-inflammatory activity and antipruritic effect. A range of specific activity of the drug makes it possible to use it for all nosological forms of skin mycoses. Zalain's high effectiveness in the treatment of skin mycoses has been proved by numerous clinical studies in Russia and abroad, which allowed the drug to be included in the group of the most priority topical antimycotics. Comparative analysis of the efficacy of sertaconazole with terbinafine and clotrimazole according to the results of scientific research of the last decade is evidence of the first рreparation. In an in vitro experiment with dermatophytia, ceraconazole has advantages over topical antimycotics of the imidazole class. It causes the death of 86.7% of fungal strains with minimal resistance (4%). With mycosis of the skin caused by yeast-like fungi Candida spp. The activity of sertaconazole is 10.8 times higher than in terbinafine. The evidence base on the safety of the drug makes it possible to use Zalain in children, beginning with a one-year-old age.