Impact of the Second Generation Antihistamines on Cognitive Function in Children with Pollen Allergy Receiving Specific Allergen Immunotherapy
Relevance. Allergic pathology and in particular pollen allergy can lead to a decrease in cognitive functions in children. Earlier it was established that antihistamine preparations of generation I influence the cognitive functions of patients. Patients with this nosology have been receiving by now longtime courses of antihistamine preparations of II generation, so the analysis of the influence of different AH preparations of II generation on the cognitive activity of children with hay fever is necessary. Purpose. Studying the impact of II generation antihistamine preparations and specific allergen immunotherapy on the cognitive functions at children with hay fever. Patients and methods. The condition of cognitive functions was established using the «Psihomat» psychophysiological computer complex. In total 81 children with pollen allergy were investigated. The persons under consideration were divided into subgroups depending on the antihistamine which they received. For the patients in the main group of investigation the cognitive functions have been studied in 3 points. Results. The patients had changes in the attention and psychomotor activity more often, than in other cognitive activity. Distinct data on a vivid contribution of second generation antihistamine preparations to the improvement of cognitive activity as a whole in complex treatment of pollen allergy with specific allergen immunotherapy was not obtained. Antihistamine preparations (desloratidine and cetirizine) improve indexes of visual and space perception in children with pollen allergy. From the 3 antihistamine preparations cetirizine has the most positive effect on the psycho-motoric activity in the combined AST. Conclusion. Additional research is necessary for receiving definite answers to the problem questions in the field.