The modern concept of the use of crystalloid cardioplegia and the results of our own research
The development of cardioplegia techniques is an important factor in the development of cardiac surgery. Improvement of cardioplegic solutions has significantly improved the outcome of cardiac surgery. One of the widely used cardioplegic solutions worldwide is custodiol, which has good safety and efficacy indicators. Nevertheless, the further development of scientific thought, a deeper understanding of the processes occurring in the ischemic myocardium, made it possible to improve the formulations of existing solutions. The introduction of additional agents made it possible to create a modified prescription - custodiol-N solution, which has all the advantages of its predecessor, as well as new qualities that allow the heart to better tolerate the state of anoxia. Domestic scientists, based on many years of experience in the study of histidine-containing dipeptides, in turn, developed a new cardioplegic solution with high buffering capacity - ASN or Bockeria-Boldyrev solution. The new solution is not inferior, and in some cases exceeds the existing analogues in terms of efficiency and safety during cardiac surgery in both adult patients and children of the first year of life.