ANTIBIOTIC RESISTANCE IN COMMUNITY-ACQUIRED INFECTIONS IN SAINT-PETERSBURG
Purpose. This study aimed to evaluate the levels of antibiotics resistance in infectious diseases pathogens in the outpatient population of St. Petersburg in 2014-2015.Methods. Over a 2-year period, clinical specimens were obtained in a large polyclinic from outpatients with community acquired infections and were cultured. Isolated bacteria underwent disk diffusion test for different antibiotics. WHONET software has been used to analyse the levels of antimicrobial resistance in 1649 strains isolated during 2014-2015.Results. The microorganisms isolated from outpatiens were distributed as follows: E.coli - 42%, S.aureus - 27%, S.epidermidis - 12%; K.pneumoniae, E.faecalis, E.cloacae - 4% each; C.koseri - 3%; all other pathogens - 4%.High levels of resistance were observed only for certain antibiotics. E.coli strains were resistant to ceftriaxone (40.0% of the strains) and ampicillin (39.8%). S.aureus showed the greatest resistance to penicillin - 83.5% of the strains. The majority of K.pneumoniae strains were resistant to ampicillin (81.5%); 60% of K.pneumoniae were resistant to nitrofurantoin. Almost 100% of strains of E.faecalis were resistant to amikacin and 66.7% to amoxicillin. All P.aeruginosa strains were resistant to trimethoprim and nitrofurantoin.With regard to other tested antibiotics, studied microorganisms were characterized by a fairly high levels of susceptibility.Conclusion. Overall, community-acquired strains isolated from outpatient population characterized by relatively low levels of resistance to the most tested antibiotic. At the same time, it has been observed high prevalence of resistance to defined antimicrobials.