Prognosis for development of severe forms of chronic generalized periodontitis in patients by finding the relationship between individual polymorphic alleles or haplotypes cytokine genes
The article analyses the frequency of the cases of distribution of genotypes and alleles of genes IL-1b and its receptor antagonist (IL-1RN) in patients with periodontitis heavy and medium-severe state and analyses the association of genotypes of these genes with the development of destructive forms of periodontitis. In the group of patients with severe forms of periodontitis polymorphism-511S / T promoter in the field of gene interleukin1b is more presented than in the comparison group and the T allele carriers met statistically significantly more frequently increasing the proportion of patients with genotips 2R/2R and allele 2R.