THE PHARMACOLOGICAL SUBSTANTIATION OF A NEW COMBINED CREAM WITH TERBINAFINE FOR TREATING NONSPECIFIC VAGINITIS
Infectious and inflammatory diseases of the genital tract, the most common of which are non-specific vaginitis, are the actual problem in modern gynecology the mixed infection is often the etiological factor of the later. At present among the variety of antifungal agents for systemic application the derivatives of azoles, which are resistant to fungi, are used. Terbinafine is a derivative of allylamines. Among vaginal drugs there are no medicines with such active ingredient for the present time. On the model of experimental traumatic-bacterial and fungal vaginitis the therapeutic effect of a new combined vaginal cream, which includes antimycotic terbinafine and antibiotic clindamycin, being not inferior to the reference drug - vagiklin by its pharmacological action, has been found. the regression index of pathological manifestations of vaginitis, such as hyperemia, edema of the mucous membranes and the presence of eroded lesions have had the same dynamics as that of the animals treated with the reference drug. It gives grounds for further clinical study of a new cream and its introduction in the gynecological practice.