IMMUNOGENETICAL FEATURES AT VIOLATIONS OF REPRODUCTIVE FUNCTION IN WOMEN EXPOSED TO PHENOLS
The polymorphic variants of candidate genes associated with immune system, violation of the women reproductive function, as well as with the metabolism of phenols have been analyzed. The study revealed that in the surveyed group, marked by high content of phenols in the blood, the higher frequencies of heterozygous genotypes of VEGF G634C, PPARD A/G, PPARA G2528C, variant homozygous genotypes of TERT C309G and PPARGC1A G1444A genes were detected. It has been noted, that the gene PPARD A/G (p<0.05) characterizes the features in women of this cohort survey. The analysis of the "hapten-genotype" systems, showed an association between the level of phenol, o- and p-cresol, and genotypes of genes: MTHFR C677T, PPARD A/G, ESR1 G2014A. The studied genes can be used as markers of sensitivity that indicates on the preconditions to the development of immunemediated disorders of reproductive function in women induced by an increased content of phenols in blood.