PLEIOTROPIC EFFECTS OF ERYTHROPOIETIN IN CHRONIC RENAL FAILURE
The paper provides information about the results of the long-term authors’research of the erythropoietin pleiotropic effects in patients with chronic renal failure. The research had been carried out for the period 2007–2013 on 134 patients with chronic renal failure on hemodialysis using the Fresenius 4008 S/BIBAG Dialysis Machine three times a week for 4 hours at the dialysis unit of Chelyabinsk Regional Hospital. Erythropoietin (EPO) was administered in the preparations «Eprex» (INN: epoetinalfa «Janssen Cilag AG», Switzerland) and «Recormon» (INN: epoetin beta, «Roche», Switzerland) at a total dose of about 40.000 IU. The affective status, psycho-physiological status, functional status of the autonomic nervous system, the quantitative composition of the blood cells, vascular, plasma and cellular homeostasis, innate immunity, cell-platelet interactions in the blood, the expression of platelet glycoprotein nitroxidergic processes and processes of free radical oxidation were investigated. The use of erythropoietin was found to result ina partial recovery of the indicators of affective, psycho-physiological status and functional status of the autonomic nervous system. EPO reduces the severity of hemorrhagic syndrome in patients with chronic renal failure due to the increased number of platelets in the peripheral blood and the restoration of platelet-cell interactions, the functional activity of platelets and endothelial cells. EPO restores the absorption capacity and oxygen-dependent metabolism of peripheral blood phagocytes in patients with chronic renal failure and enhances the function of phagocytes in in vitro. Neurotrophic mechanism and immune hemostatic effects of erythropoietin in patients with chronic renal failure is implemented through the anti-anemic, Lipid peroxidation-limiting and detoxifying action.