HEALTH STATUS IN PERSONS OF REPRODUCTIVE AGE WITH METABOLIC SYNDROME
Introduction. As noted in the state program for the development of healthcare of the Republic of Kazakhstan for 2020-2025, the emphasis on non - communicable diseases with high prevalence rates and prone to steady growth is one of the characteristic features of healthcare in Kazakhstan and all developed countries. Among the signs important for understanding health, a special place is occupied by the state of health of the population of reproductive age. Since it is a necessary condition for the well - being of future generations and the guarantee of a sufficient population in the state. Objective: To determine the health condition of the reproductive age people of suffering from MS.Methods. Study design: observational, simultaneous, case - control. The study involved 1065 people aged 18 to 49 years, the average age was 40.2 years. Metabolic syndrome in respondents was determined according to the IDF criteria (2005). Statistical analysis was performed in the SPSS 24 program. Pearson's test, χ2, Welch T test in two samples, non - parametric Mann-Whitney test for independent groups were performed. The statistical reliability of the indicators was assessed at the level of p <0.05. Research results. Hemogram indices, lipid profile, body weight, waist volume, visceral fat index, liver enzymes, renal function indices, the state of the common carotid artery layers, biological age indices and the aging rate coefficient were higher in study participants with metabolic syndrome compared with respondents without metabolic syndrome ( p <0.05). Conclusion. Thus, it was found that patients with metabolic syndrome suffer from obesity, which is accompanied by an excessive accumulation of visceral fat, an increase in the waist volume and body mass index. In patients with metabolic syndrome, the functions of the liver, kidneys, heart are impaired, and the indices of general clinical and biochemical blood tests are changed. In connection with these changes, a greater biological age of patients was revealed, i.e., a faster aging process. In addition, individuals with metabolic syndrome were found to have abnormalities in the structure of the heart and changes in the carotid artery, leading to atherosclerosis.