INFLUENCE OF COMBINED CARRIAGE OF LIPID TRANSPORTING SYSTEM GENES POLYMORPHISMS ON THE GRADE OF CORONARY ATHEROSCLEROSIS IN UNSTABLE ANGINA PATIENTS
Aim. To study the specifics of lipid metabolism and involvement of coronary flow according to combination carriage of “ε4”-allele s2s3s4 polymorphism of gene apolipoproteine Е (Apo Е) and “S2”-allele SstI polymorphism of gene apolipoproteine СШ (Apo СШ) in unstable angina patients. Material and methods. Totally, 141 patients assessed, with unstable angina and angiographically proven coronary atherosclerosis. Comparison group - 50 healthy persons. Genotyping of s2/s3/s4 polymorphism gene Apo Е and SstI polymorphism gene Apo СШ was done by PCR. Results. 37 were selected to one group of patients with the carriage of “harm” alleles: “ε4” and “S2” - (I group), versus the others (II group) - 104 patients. In comparison of lipid profiles, I group showed significantly higher levels of total cholesterol (238,0±54,3 mg/dL) and low density cholesterol (LDL) (154,7±51,5 mg/dL) (Р<0,05), than levels of TC (220,6±39,8) and LDL (138,8±37,6) in II group. Also, in I group patients there was lower HDL cholesterol (34,1±6,3, P<0,05), comparing to II group (36,8±6,8). Level of apolipoproteide В (Apo В) was slightly higher (115,0±24,9 mg/dL), and level of apolipoproteide А-I (Apo А-I) - lower (133,8±21,3) in group I, that led to significantly higher relation of Apo-B/Apo-A- I - 0,9±0,3 (P<0,05), comparing to group II (107,0±25,7, 139,1±22,2 and 0,8±0,2), respectively. Conclusion. Carriage of alleles “S2” SstI polymorphism gene apo CIII and “ε4” s2s3s4 polymorphism gene Apo Е is predetermining factor for development of coronary atherosclerosis and atherogenic dyslipidemia among uzbeks. According to coronary arteriography, in the I group patients had more commonly three - and multivessel disease (Р<0,05).