The new possibilities for the rehabilitation of conserved erythrocytes with the use of ozone
The objective of the present study was to develop the method for pre-transfusion rehabilitation of conserved erythrocytes with the use of an ozonated 0.9% NaCl solution and to estimate the effectiveness of their application in the patients suffering from the loss of blood of ulcerative etiology. This paper reports the experimental data obtained during the development of the optimal method for the pre-transfusion treatment of the erythrocytes conserved with the use of ozonoted physiological solution. Moreover, the results of their clinical application are reported based on the treatment of 63 patients presenting with non-varicose gastrointestinal hemorrhage hospitalized in the state of grade III hemorrhagic shock. It was shown that the preliminary treatment of the erythrocytes with ozonated physiological solution improves the results of transfusion therapy of hemorrhagic shock due to the reduction of the severity of tissue hypoxia and activity of pro-oxidative processes with the simultaneous stimulation of the anti-oxidative system, improvement of the parameters of systemic hemodynamics and the clinical course of the early post-hemorrhagic period.