The morpho-functional state of the rat liver after the influence of the dihydropyrrol derivate under oxidative stress condition
There were investigated the dihydropyrrol derivative influence on the morpho-functional state of the rat liver under oxidative stress condition, provoked by CoCl2. It was established, that oxidative stress provoked the significant changes in the liver microcirculatory system such as dilatation and constriction of sinusoids and provoked the appearance of inflammation focuses around the vessels and bile ducts. D1 action on the liver leaded to hepatocites nuclei enlargement and sinusoid hemocapillars dilatation. Dihydropirrol derivate partly prevents from inflammation focuses appearance under CoCl2 influence, but enlarges the changes of sinusoid hemocapillars. There were ascertained the enlargement of hepatocites nuclei in periportal and centrolobular zones after the influence of dihydropyrrol derivative under oxidative stress condition