Drug-Induced Movement Disorders: Study of the Mechanisms and the Strategy for the Development of Personalized Therapy Approaches
The main method of schizophrenia treatment is an antipsychotic therapy, which often cause a wide range of side effects (movement, metabolic, cardiovascular and other disorders). Tardive dyskinesia (TD) stands out among drug-induced movement disorders, occurs in the case of long-term antipsychotic therapy and significantly reduces the quality of life of the patient. The aim of this study was to investigate the mechanisms of tardive dyskinesia and to develop the approaches to personalized therapy. The conducted studies have revealed clinical, socio-demographic, biochemical and pharmacogenetic risk factors that are important in view of the use of various antipsychotics and the need for early stages of therapy to be able to predict the long-term side effects of treatment.