Interferon Genesis Induction Under Acridone Acetic Acid Influence and its New Compounds with Sanogenand Thymogen-Peptides
When simultaneously administrated, the original tripeptide sanogen, that we have had synthesised, and acridone acetic acid (АAA) in mice revealed expressed synergy in the induction of «early» and «late» endogenous interferon that has high antiviral activity. For the first time we have showed that the well-known dipeptide immunomodulatory thymogen consisting of glutamic acid and tryptophan, induces interferon production with significant antiviral activity in systems in vitro and in vivo. Our study in mice and human blood cells revealed, that based on glutamyl-tryptophan and acridone acetic acid new low-molecular preparation TAUK, that we have synthesized, is a promising inducer of interferon with enhanced antiviral activity.