The processes of neurogenesis and neurodegeneration in depressive disorders
It is known that the depressive disorders develop in the conditions of chronic oxidative stress with the alterations of immune-inflammatory processes. Oxidative stress and proinflammatory cytokines provoke neurodegenerative processes and antineurogenetic effects in brain tissue in depressive disorders. In our paper we analyze the basic neurotrophins and their key role in the processes of neurogenesis. We also evaluate their participation in cell proliferation and differentiation of brain tissue in grown mice species. The neurotrophic mechanisms in processes of neurogenesis and functional role of the receptors are also discussed. The impact of the decrease in neurotrophins level on the alterations of neurogenesis is also evaluated in present review. The positive effects of antidepressive therapy in these cases are discussed. The studying of molecular mechanisms of depression from neurodegenerative/neurogenesis perspectives gives the opportunity to create new approaches to depression treatment.