GENETIC ASPECTS OF THE FORMATION OF BRONCHOCONSTRICTION REACTIONS IN CHILDREN WITH BRONCHIAL ASTHMA UNDER CONDITIONS OF LOW TEMPERATURES IN YAKUTIA
The article presents the results of the first study of the features of the formation of cold hyperreactivity of the respiratory tract (CHRT) among the child population at low temperatures of the Republic of Sakha (Yakutia) by searching for the Association of polymorphic variant (rs1042713) A46G and polymorphic variant (rs1042714) C79G gene β2-adrenergic receptor ADRB2 in the group of patients with asthma and healthy individuals, yakut by ethnicity living in the Republic of Sakha (Yakutia). A total of 326 DNA samples isolated from venous blood were analyzed, of which 103 DNA samples belong to patients with bronchial asthma and 223 DNA samples belong to individuals who do not have a history of pathology of the bronchopulmonary system. According to the results of the study, the association of allele A and genotype AA polymorphic variant (rs1042713) A46G, as well as the genotype GG polymorphic variant (rs1042714) c79g gene β2-adrenoreceptor ADRB2 with the risk of developing a predisposition to bronchoconstrictor reaction in response to inhalation of low temperature air. These genetic markers can be used as risk factors in predicting the formation of cold airway hyperreactivity and the development of side effects of regular therapy with β2-agonists in Yakut children with Bronchial asthma.