Predictive prognostic value of neutrophil to lymphocyte ratio in patients with myocardial infarction
Background: The problem of predicting post-hospital mortality in patients with myocardial infarction (MI) is an urgent area of scientific research. Aims: To determine the possibility of neutrophil to lymphocyte ratio (NLR) in predicting post-hospital mortality in patients with MI. Materials and methods: 410 patients over 18 years old hospitalized with MI within 24 hours after development of clinical symptoms were included into a study (88% of them men, average age 50 (43.5; 55.0) years). In addition to a standard examination, NLR values were determined and recorded. Information on the life status of patients included in the study was obtained one year after the onset of MI. Statistical analysis was carried out using the IBM SPSS Statistics v.20, v.23 computer software package. Results: The NLR was found to be a significant predictor of post-hospital mortality (area under curve 0.69 ± 0.07, 95% confidence interval (CI): 0.55-0.83, p = 0.015). An NLR value more than 4.52 was accompanied by an increasing the probability of a fatal outcome by 5.86 times (OR = 5.86, 95% CI: 1.66 - 16.83, p = 0.005). At the selected threshold value, the model sensitivity was 66%, specificity - 76%. Kaplan-Meyer analysis showed that the dependence of the risk of death within 12 months after discharge with an NLR value of more than 4.52 was statistically significant (Log rank test, p = 0.037). Conclusions: The results of this study show that NLR could be a simple but effective marker for post-hospital mortality prediction in patients with MI