INTRONIC POLYMORPHISMS OF АNTIONKOGENE <i>TP</i>53 IN PATIENTS WITH INDOLENT VARIANTS OF NON-HODGKIN'S LYMPHOMAS
The frequency of distribution of alleles and genotypes of single nucleotide substitution G 13494 A in intron 6 and duplications dup 16 bp in intron 3 of the gene TP 53 in 56 patients with indolent non-Hodgkin's lymphoma and variants in the controls was studied. The increase of the frequency of G -allele and G/G genotype of intron 6 of the gene TP 53 in lymphoma patients compared with controls (91 and 84 % vs. 79 ( p <0,01) and 63 % ( p <0,01), respectively) was determined. It was found that individuals carrying the rare A -allele (i.e., having A/G or A/A genotype), had the risk of disease 3,23 times ( OR =3,23; [95 % CI 1,50; 6,92], p <0,05) higher than the general population. No signiﬁcant differences in the distribution of alleles and genotypes of dup 16 bp intron 3 of the TP 53 gene between cases and controls were identiﬁ ed. The results indicate that the oligonucleotide G 13494 A substitution in intron 6 proapoptotic gene TP53 in older individuals may have a modulating effect on the risk of indolent lymphoma.