THE RISE OF CARDIAC BIOMARKERS DUE TO PLANNED PCI AND 1-YEAR PROGNOSIS
Aim. The aim of our study was to assess the prevalence and prognosis of myocardial infarction (MI) type 4a and myocardial damage due to planned PCI in Russian population. Material and methods. 281 patients were screened before the enrollment in our study. 183 patients with stable CAD were included in our study whose levels of cardiac troponin I and MB-KK were studied after PCI. We divided patients into the groups according to their levels of cardiac troponin I after PCI (group I - no elevation, group II - elevation 1-3 upper limits of normal (ULN), group III - more than 3 ULN) and MB-KK (group I - no elevation, group II -1-3 ULN, group III - more than 3 ULN). Results. The prevalence of MI type 4a was 10,7% and periprocedural myocardial damage - 14% respectively. After performing the discriminant analysis we sought to build a prognostic model and calculate the formula of periprocedural myocardial damage probability: 0,871*gender (male = 0, female = 1)+0,516*(angina pectoris functional class)+0,022*age (years)-0,011*eGFR (MDRD)+0,27(number of diseased coronary arteries)≥2,731. MI type 4a doesn't increase 1-year mortality according to our data. Conclusion. MI type 4a (with chosen diagnostic criteria) and myocardial damage after planned PCI do not enhance the probability of death and CHF decompensation during 12 months after the procedure. According to our data, the cardiac biomarkers' rise after planned PCI without any other clinical and instrumental evidence doesn't influence the 1-year prognosis in Russian population.