SULODEXIDE AS A CHOICE OF PREVENTION OF BISPHOSPHONATE OSTEONECROSIS
In the study, 36 rats were taken to cause drug osteonecrosis of the jaw after tooth extraction during the application of Zoledronic acid. Rats were divived into 4 groups. Group 1 was injected with saline by intravenous administration. Group 2 was injected with zoledronic acid triply by intravenous administration. Group 3 was injected with zoledronic acid 6 times by intravenous administration. Group 4 was injected zoledronic acid by intravenous administration and then sulodexide was administered intramuscularly. All rats after the final administration of the drug zoledronic acid on day 3 have undergone the extraction of mandibular premolar on the left and then we evaluate hemodynamics of microvasculature of parodont from vestinular side in the location of extracted tooth a week later (after final application of zoledronic acid) with application of acetylcholine and with ultrasonic and laser Doppler examination.