CHARACTERISTIC OF PNEUMOCOCCAL POST-VACCINATION IMMUNITY IN HIV-POSITIVE PATIENTS THROUGH 2 YEARS AFTER IMMUNIZATION
At present, the problem of vaccination of HIV-infected patients from pneumococcal disease is still poorly studied. There is no consensus on the effectiveness of immunization, the appropriateness and timing of revaccination. The aim of the study was to examine the duration and power of post-vaccination pneumococcal immunity in HIV-infected adult patients. A prospective comparative randomized study was performed, 100 HIV-infected patients were vaccinated with a polysaccharide 23-valent pneumococcal vaccine. Comparison group was consisted of 100 cases, not vaccinated against pneumococcal infection. For detection of the power of immunity through 2 years blood serum level of IgG antibodies to a mixture ofpolysaccharides (SP) S. pneumoniae incorporated in the vaccine were determined, the comparison of the incidence of acute respiratory infections, pneumonia and bronchitis was carried out, and their etiological transcript with the help of bacteriological examination of sputum was performed. The obtained results indicate to the powerful post-vaccination immunity with the high level of seroprotection and significant preventive effect through two years after vaccination.