Study on Antitumor Activity of Probiotic Bacteria and Their Association on Tumor Growth Model and Cell Culture
Selection of strains of lactic acid bacteria, propionic acid bacteria, and the A-5 association, comprising the cultures Lactobacillus brevis B-3/A-26 + L. plantarum 2v/А-6 + L. plantarum 14d/I + Propionibacterium shermanii 2/10 in equal proportions, with high antitumor activity was carried out on the tumor-like growth model of the fungus Fusarium bulbigenum variant blasticola. L. acidophilus 27w, L. plantarum 2v/I, 2v/A-6 and 22A-310, L. fermentum 127A-4, L. cellobiosus 7n, L. salivarius 39n, P. shermanii 2/10, and the “А-5” association completely suppressed the tumor-like growth of the fungus at a 2% concentration of native cultures in a nutrient medium. High antitumor activity of the “А-5” association was confirmed on the human tumor cell lines of various organ origin (HepG2, RD, and H9), comparable with the therapeutic agents doxorubicin and cyclophosphamide. It was established that the strains that compose the “A-5” association were resistant to the tested antitumor drugs doxorubicin and methotrexate.