THE ROLE OF AMPK AND MTOR IN THE DEVELOPMENTOF INSULIN RESISTANCE AND TYPE 2 DIABETES.THE MECHANISM OF METFORMIN ACTION(literature review)
It was analyzed the cellular and molecular links between chronic low-grade inﬂammation andcaused by inﬂammation insulin resistance and type 2 diabetes. Particular emphasis is placed on theparticipation of AMPK and mTORC1 in the development of metabolic diseases caused by obesity. Adetailed analysis of the biochemical mechanisms of action of the main drug used in the treatment ofinsulin resistance and type 2 diabetes - metformin.