Use of mineral water in rehabilitation therapy of patients with nephrolithiasis
Background. Study of alternative non-pharmacological methods of rehabilitation therapy is an actual task in the direction of preventive and restorative medicine. An important role in rehabilitation measures in preventing urolithiasis relapse is therapy using balneological therapeutic methods. The aim of the study was to perform a clinical and laboratory analysis of the effectiveness of mineral water “Serebrjanniy kluch” (Silver Rill) in rehabilitation therapy for patients with urolithiasis. Materials and methods. The study is based on the results of survey data analysis and treatment of 36 patients with urolithiasis. All patients were randomized into two groups: the first (control) group comprised 17 patients who received standard conservative therapy (antispasmodics and analgesics) and fresh drinking water and the second (main) group comprised 19 patients who received standard conservative therapy and mineral drinking water “Serebrjanniy kljuch” at 5 ml/kg of body weight per serving, at 18°C-25°C for 30-40 minutes before meals 4 times a day in an outpatient setting. Results. In the second group, self-sustained calculus removal was recorded in 78.9% of cases, and there was an increase in daily diuresis in all patients, a decrease in the excretion of oxalate and uric acid in daily urine by 52.3% and 49.9%, respectively, and decrease and normalization of lactate dehydrogenase, leucine aminopeptidase, and N-acetyl-β-D-glucosaminidase concentrations were 28.3%, 24.5%, and 12.5% (p < 0.05), respectively. In addition, the decrease and normalization of the accumulation time indicators were registered 2.7 times (p < 0.05), the half-life period was 2.1 times (p < 0.05), and the glomerular filtration rate increased by 60.1% (p < 0.05) with simultaneous improvement in microcirculation of the kidneys. Conclusions. Consuming mineral water “Serebrjanniy kljuch” as a part of rehabilitation therapy of patients with urolithiasis positively influences the clinical course of the disease, helps reduce the excretion of oxalates and uric acid in daily urine, reduces enzymes, and leads to an increase in daily diuresis. (For citation: Nejmark AI, Saldan IP, Davydov AV. Use of mineral water in rehabilitation therapy of patients with nephrolithiasis. Urologicheskie vedomosti. 2018;8(2):18-23. doi: 10.17816/uroved8218-23).