CELL IMMUNITY INDICES IN CREW MEMBERS OF THE "MOON-2015" PROJECT
Cell immunity was studied in 6 female participants in the “Moon-2015” project at the age of 25 to 34 years. Peripheral blood was analyzed for lymphocyte subtypes CD3<sup>+</sup>, CD3<sup>+</sup>CD4<sup>+</sup>, CD3<sup>+</sup>CD8<sup>+</sup>, CD19<sup>+</sup>, CD3<sup>-</sup>CD16<sup>+</sup>CD56<sup>+</sup>, and monocytes and granulocytes that express signal recognition receptors of the Toll-like (TLR) family (TLR2, TLR4, TLR6) localized on the cell surface. Results of the investigation showed a distinct effect of short-term isolation on the immune system's ability to mobilize. Rotation on a short-arm centrifuge (SAC) together with 9-day isolation in a chamber caused diverse responses of the adaptive and innate immune systems. Apparently, they manifest a complex adaptation process in the innate and acquired immunity on the early stage of adaptation to isolation and also during exposure to +Gz accelerations (head-to-pelvis) on SAC.