Clinical and pathogenic efficacy of various drug treatment regimens in case of atopic dermatitis in children
Despite of advances of modern drug therapy of atopic dermatitis (AD), clinical implementation of standards for tracking of such patients, the majority of physicians prefer treatment strategy aimed towards reduction of symptoms of a disease. Medicines preventing AD attack are usually used with indication violations resulting in ambiguous attitude towards their efficacy Chronic skin inflammation in case of AD are associated with abnormality in components balance of skin surface hydrolipid film (SHF) being a key marker of inflammatory process activity in case of dermatitis. The survey aimed at analysis of comparative efficacy of Pimecrolimus and topical corticosteroids (TCS) in children with severe and mild AD was carried out. The survey comprised children (n=60) suffering from minor or mild AD. Clinical symptoms dynamics was assessed on the basis of TIS index and symptoms scale; the initial and end ratio of lipids was assessed under the method developed by J. Folch (1957). It was discovered that Pimecrolimus is efficient for minor AD (minor AD symptoms), the probability of complications when using Pimecrolimus is lower (OR 1,3; р<0,05) as compared to TCS.