Diagnostic informativeness of determination of PCA3 gene expression in urine sediment and exosomes in patients with prostate cancer
The diagnostic and prognostic significance of the PCA3 gene expression in urine sediment and exosomes was evaluated in 148 patients with prostate cancer (PC) with a clinical stage T1c-T2cN0M0. Radical prostatectomy (RPE) was performed in all patients. For two years after RPE in patients every three months, the presence or absence of biochemical relapse (BR) was monitored. It was established that the expression level of the PCA3 gene in urine exosomes in prostate cancer patients with subsequent biochemical recurrence was significantly lower compared to the favorable course of the disease (p=0,01), and the association with PSA concentration in the blood and expression of transcription factors in the tumor tissue of operating biopsies and homeobox proteins closer. It was concluded that the assessment of the expression of the PCA3 gene in urine exosomes is informative for predicting the development of BR in the next 2 years after RPE.