Results of a goal-oriented prostate cancer screening program in the Penza Region
Prostate cancer (PC) has been recently the most common male cancer disease. At the same time, its incidence is ever increasing. In this connection, PS screening is highly pressing. Objective: to study and assess the first results of a regional goal-oriented PC screening program in the Penza Region. Subjects and methods. The regional goal-oriented Male Health program for PC screening was launched in the Penza Region in February 2008. The serum level of prostate-specific antigen (PSA) was detected in all 45-to-70-year men who had visited the regions polyclinics and hospitals for any disease. Digital rectal and transrectal ultrasound studies were additionally performed in patients having the symptoms of lower urinary tract dysfunction. When the PSA level was > 4 ng/ml, multifocal biopsy was made through transperineal and transrectal accesses under ultrasound guidance, by using 12-24 points. Results. In February 2008 to June 2010, blood was tested for PSA in 55 of 103 patients. In 5910 (10.7%) of them, its level (> 4 ng/ml) was above the allowable limit. Multifocal prostate puncture biopsy was performed in 1695 patients with elevated PSA levels for further examination to rule out PC. The latter was established by the results of biopsy in 737 patients. The percentage of biopsy results positive for cancer was 38.9%. That of PC detected among all the men examined for serum PSA level was 1.3%. Conclusion. To elaborate programs for the early diagnosis and screening of PC is one of the priorities of the development of oncourology, which can considerably improve the results of treatment for this disease.