Translational and post-translationalregulation of activity of hif-1 in hypoxia and ischemia
This review covers current concepts on the structure, function, regulation of translation and post-translational modifications of hypoxia-inducible factor 1 (HIF-1). In addition, the role of this transcription factor in hypoxia and ischemia is discussed. We focus on using HIF-1 as a molecular target for new pharmacological therapeutic strategies in wide spectrum of diseases associated with alterations in energy metabolism.