THE INFLUENCE OF ESTRIOL ON CTLA-4 EXPRESSION AND IL-17 PRODUCTION
The influence of pregnancy hormone estriol (E <sub>3</sub>) in doses, characteristic for pregnancy, on functional T regulatory cells marker CTLA-4 and IL-17 production by women peripheral blood lymphocytes was studied. It is established that E <sub>3</sub> increases percentage of CD4+CD152+ cells and decreases IL-17 production. Thus, the hormone could be one of the factors which contribute to immune tolerance formation at pregnancy.