HYPOTENSIVE TREATMENT IMPACT ON PARAMETERS OF VASCULATURE RIGIDITY AND RENAL HEMODYNAMICS IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS
56 patients with hypertonic variant of chronic glomerulonephritis (CG) and preserved kidney function (GFR 82.3±3.6 ml/min) were examined; among them were 20 males and 36 females with the average age 40.3±6.5 years old. Morphological verification of CG was carried out in 16 patients - they were diagnosed with mesangioproliferative variant of chronic glomerulonephritis. Changes in structutal-functional vasculature properties, characterized by the increase of pulse wave transmission velocity, decrease of pulse wave transmission time (PTT), rigidity (ASI) and augmentation (AIx) indices were determined in patients with hypertonic variant of chronic glomerulonephritis. Significant correlation relationships were determined between the pulse wave transmission velocity, augmentation index and indices of renal peripheral resistance (Ri, Pi). It was found out that the combination of zofenopril and felodipine had a more prominent anti-inflammatory, vasoprotective and organ-protective activity compared to zofenopril plus amlodipine use.