Mechanisms of development of morphologocal equivalent of DIC-syndrome
Mechanisms of development of a morphological equivalent of DIC-syndrome during experimental lactate-acidosis were studied. Under lactate-acidosis of various depth (from рН 7,2 to рН 6,5) and durations (from 30 to 180 minutes) morphological signs of microcirculation disorders were found in heart, lungs, liver, gastrointestinal tract, kidneys; erythrocytes - sludges and blood clots f xed to subendothelium in large vessels were formed. Under electronic microscopy cytoplasmatic membrane deformation, micro vesicle formation, malfunction of endothelium structure were found: from edema and swelling of mitochondria to complete cell destruction, leaving out of all organelles to intercellular space and blood that led to DIC-syndrome