The frequency of mutations of hemostasis plasmic link genes possessed by women with miscarriage of pregnancy in the anamnesis
The main goal of the research is to investigate the frequency of various mutations of genes which code the factors of hemostasis system (hereditary thrombophilia) possessed by women with pregnancy miscarriage in anamnesis and to reveal the most pronounced mutations in the genesis of customary interruption of pregnancy. Two groups of women have been included in the investigation, a group with customary miscarriage and a group with only one case of pregnancy miscarriage in the anamnesis. A molecular-genetic analysis of allelic polymorphisms (mutations) coding a number of hemostasis factors has been carried out for every woman. In the group with customary miscarriage the frequency of the combined mutations of genes associated with the risk of thrombophilia development is reliably higher. It is advisable to investigate women with pregnancy miscarriage in the anamnesis in order to reveal mutations of genes which code the hemostasis factors in order to determine the prognosis of further pregnancies.