OPTIMIZATION OF THERAPY OF ACUTE INTESTINAL INFECTIONS IN CHILDREN WITH ATOPIC DERMATITIS BY ENTEROSORBENTS
A comparative analysis of the use of different enterosorbents in children with acute intestinal infections in combination with atopic dermatitis. On the background of the use of different enterosorbents (Smecta, Polisorb MP, Enterosgel) were estimated in terms of relief of dyspeptic symptoms, inflammatory changes by microscopy of feces, the content of secretory immunoglobulin in coprofiltrates, the content of immunoglobulin E in the serum, cutaneous manifestations of atopic dermatitis. In assessing the effectiveness of enterosorbents in children with acute gastroenteritis associated with atopic dermatitis, it was found that in groups of patients receiving Polisorb MP and dioctahedral smectite, the majority of pathological symptoms were stopped by the end of 3 days of inpatient treatment in 79% and 84% of patients, respectively. In patients receiving enterosorbent Enterosgel, full clinical efficacy on the 3rd day from the beginning of treatment was noted only in 67%. The level of secretory IgA before discharge was significantly higher in groups of patients receiving Polysorb MP (2.10±0.11 g/l) and dioctahedral smectite (2.30±0.16 g/l) than in children receiving enterosgel (1.40±0.16 g/l). Normalization of the program in faster terms was noted in the 1st and 3rd groups. The duration of clinical manifestations of atopic dermatitis and a significantly more pronounced decrease in the IgE concentration at discharge in groups of children receiving Polisorb MP and Enterosgel as enterosorbents in comparison with the group of Smecta patients.