ENDOTHELIN-1 AND ADIPONECTIN IN PATIENTS WITH IMPAIRED GLUCOSE TOLERANCE AND TYPE 2 DIABETES
Material and methods of the study. 76 patients with type 2 diabetes (27 men and 49 women) middle aged 58,6±1,0 years and 73 patients (11 men and 62 women) with IGT of middle aged 61,7±1,4 years were examined. The control group contained 22 practically healthy patients (11 men and 11 women) of middle aged 23,1±1,0 years. Other control group contained 16 practically healthy patients (8 men and 8 women) of middle aged 46,7±2,0 years. The results of the study. The patients with IGT and type 2 diabetes had atherogenic dislipidemia and hyperinsulinemia due to visceral obesity and insulin resistance. The reduction of adiponectin serum concentrations was revealed in women with IGT and type 2 diabetes, but in men with type 2 diabetes only. The endothelin-1 level was much higher in IGT women. In men with IGT and type 2 diabetes were not revealed reliable diﬀerences of endothelin-1 serum concentrations. Study ﬁndings: dislipidemia and hyperinsulinemia and also reduction of adiponectin level and increase endothelin-1 level determined on stage of impaired glucose tolerance already, especially in women with IGT.