The Study of Reparative and Immune Potential of <i>Bacillus Sp</i>. Bacteria from Permafrost
A high reparative potential of <i>Bacillus sp</i>. bacteria is set on the skin wound model. The bacteria have been isolated from permafrost and their metabolic products - metabolites. The most effective are the “thermal” metabolites produced by culturing the bacteria at 37°C. When applied locally to the wound, they optimize the regenerative process: reduce the time of wound contraction, retract a scar tissue, and renew a coat. The ointment with “thermal” metabolites accelerates the repair process by 30% relative to the ointment base, by 20% - relative to the Solkoseril pharmaceutical, and by 10% - relative to the bacteria themselves. The dynamics of the formative processes in the healing of skin defects under the influence of <i>Bacillus sp</i>. bacteria and their metabolites are correlated with the dynamics of the immune system activity. The sequence of changes in the activity of various parts of the immune system (nonspecific immunoresistance-cellular immunity - humoral immunity) corresponds to the phases of the reparation process (damage - inflammation - recovery). Based on these data, <i>Bacillus sp</i>. metabolites can be attributed to the modulators of the reparation process with predominant regeneration mechanisms.