Features receptor status of tumor in synchronous and metachronous bilateral breast cancer
The work examines the characteristics of the receptor status of the tumor with synchronous and metachronous bilateral breast cancer. Studied surgical material from 44 patients with bilateral malignant tumors of this localization: 22 patients were recorded synchronous and 22 patients metachronous breast tumors. The predominant histological type was invasive carcinoma nonspecific type. We conducted immunohistochemical examination of the tumor tissue showed that in synchronous bilateral breast cancer is dominated by positive receptor status with the simultaneous combination of the expression of receptors for estrogen and progesterone, and the most common is the luminal A molecular genetic type of neoplasm. Metachronous tumors significantly more likely to have a negative receptor status with the lack of expression of receptors for estrogen and progesterone, and dominant among them is three times the negative molecular genetic type of tumor.