NEUROMEDIATOR DISORDERS IN THE BRAIN STEM AND THE CEREBELLUM OF RAT BRAIN IN CHRONIC MORPHINE INTOXICATION
The effects of chronic morphine intoxication on the functioning of dophaminergic, noradrenalinergic, serotoninergic systems, and GABA level in the brain stem and the cerebellum of rat brain have been studied. Thus the most prominent neuromediator disorders have been revealed in the brain stem on the 14th day of morphine intoxication. It is manifested by a falling level of dophamine, noradrenaline and serotonine. The increase in concentration of GABA in the cerebellum on the 7th and 14th days of chronic morphine intoxications has been noted.