Application of Silicon Microchannel Matrix for Size-Dependent Cell Separation
For size-dependent cell separation it was proposed to use a microfluidic device with a separating component of silicon microchannel matrix obtained through electrochemical etching of <i>p</i>-type silicon. Marginal conditions (steam speed, particle concentration) for operation of microfluidic device were defined, conditions for cell separation were optimized and in a model system it was shown that such a device enables efficient separation of cells with size exceeding 10 µm from blood circulation.