DIAGNOSTIC VALUE OF PROTEIN S100 AND BRAIN-DERIVATED NEUROTROPHIC FACTOR (BDNF) BLOOD LEVEL INDEXES IN SMALL PREMATURE INFANTS
Searching of early diagnostic criteria of the severity of hypoxic-ischaemic encephalopathy and indicators of brain trophic protection in children with extreme and very low birth weight is up to date. The aim of this study is to determine diagnostic value of glial protein S100 and brain-derived neurotrofic factor (BDNF) blood level indexes in small premature infants with perinatal hypoxic - ischaemic encephalopathy during the first year of life. Material and methods. The comprehensive clinical and laboratory examination of 60 such children were performed during the first year of life. Depending on the degree of cerebral ischemia the two subgroups were revealed: I (n = 30) - children with moderate cerebral ischemia (CI II), II (n = 30) - children with severe cerebral ischemia (CI III). The comparison group consisted of 16 healthy full-term infants without hypoxic-ischaemic encephalopathy. The serum level of glial protein S100 and BDNF was determined by enzyme immunoassay. Results. Some clinical features of hypoxic-ischaemic encephalopathy during the first year of life of very preterm infants were found. The diagnostic role of glial protein S100 in determine the severity of cerebral ischemia in children with extreme and very low birth weight in the early neonatal period was revealed. There was observed the serum reduction in the number of BDNF in children with severe hypoxic-ischaemic encephalopathy. It's indicate the reducing the reparative processes level in this group of children.