METABOLIC DYSFUNCTION OF THE PLACENTA IN PREGNANT WOMEN WITH ARTERIAL HYPOTENSION
To elucidate the pathogenesis of placental insufficiency in pregnant women with arterial hypotension (AH) examined 140 patients with study extragenital disorders in pregnancy 8 - 24 weeks. In blood of pregnant women was determined the content of thermostable alkaline phosphatase (TAP), trophoblastic β-glycoprotein (TBG), total (TCA) and effective (ECA) concentration of albumin, total content of SH-groups and their non-protein fractions and urine levels of human chorionic gonadotropin (HCG), estriol (E), glukuronic acid (GA). It is found that along with reduced concentration of HCG, TBG, TAP, E in pregnant women with AH there is also a lack of SH-groups, ECA in the blood and GA in the urine – base chemicals involved in conjugation and inactivation of hormones. Proposed indicators along with the standard (HCG, TBG, E), used as prognostic markers for developing placental insufficiency.