Adaptive immunity, systemic inflammation and cytokine levels in patients with Alzheimer’s disease of different severity and with amnestic mild cognitive impairment
The aim of this work was to study the main parameters of humoral and cellular immunity and the levels of basic cytokines in patients with amnestic mild cognitive impairment (n=100), with Alzheimer's disease (n=45) and in the control group (n=40). We examined 1 00 patients diagnosed with amnestic mild cognitive impairment, 45 patients with Alzheimer's disease, 40 people in the control group. We evaluated the levels of immunoglobulins (Ig A, M, G), C-reactive protein, circulating immune complexes, cytokines (IL-1 ß, IL-2, IL-4, IL-8, IL-10, ИФНа, ИФНу, IL-12) in serum by ELISA, and the parameters of cellular immunity were studied by flow cytometry. Significant differences were found in the levels of cytokines IL-1 ß and ФНОa, as well as in cellular immunity, depending on the stage of cognitive disorders. The results are important for the development of methods for the early diagnosis of Alzheimer's disease at the preclinical stage and for the search for new targets of targeted therapy.