The actual approaches to therapy of refractory migraine
The refractory migraine is a severe version of migraine with many unclear and contradictory related issues. The main problem of such patients is in absent or minimal effect of standard anti-migraine therapy both in prevention of attack and rapid relief of symptoms. Hence the most difficulties are related to tactics of management of hard-curable patients with refractory migraine. The therapy is more often selected in empirical way and individually for every patient. This process takes much more than one month and the main purpose of treatment is to decrease level of deadaptation. In this connection, during management of this category of patients the most justified is multidisciplinary approach coupled with rational combined pharmacological therapy with large specter of non-pharmaceutical methods of exposure.