Off - label use of drugs - important problem of modern pharmacotherapy
Marketing authorization for a drug is granted to the holder according to the results of pre - clinical and clinical studies and positive benefit - risk assessment. However, sometimes healthcare specialists prescribe drugs for off-label purposes. Off-label use of drugs may be associated with increased risk of serious adverse drug reactions, including death. In this article you may find pharmacoepidemiology of adverse drug reactions caused by off-label use of medicines and legal framework on the subject.