INTEGRATIVE BIOEFFECTS OF DEPLETED URANIUM
The results of histochemical, immunohistochemical and morphometric studies after a single exposure of depleted uranium after one, three and six months to organs with different refresh rates are presented in the article. The Substantial changes in the investigated criteria characterizing the bioeffects in terms of their severity are established. The Image-analysis used in the morphometry of the light-optical density of the enzymes' distribution that determine the near-wall and intracellular digestion in the epithelium of the lean and large intestines made let to establish violations and desynchronization of all processes. The number of intraepithelial lymphocytes and Ki67 + cells of the crypt epithelium varied as markers of mitotic cells. A certain pattern of reaction with an inverse relationship, including the timing of observation is marked between them. It was established lesion of the parotid gland in the remote terms after the introduction of depleted uranium. А high sensitivity of the glial component and a redistribution of the ratio of morphofunctional types of secretory neurons with a finding of barrier disorders by indices of the perineuronal index are marked In the SOC of hypothalamus. Analysis of the correlation of the intestines' investigated criteria, characterized by a high rate of renewal, determined the adaptive nature of some of them, which did not lead to a favorable outcome. The nature of adaptability was not manifested in the indices of the hypothalamus SON's secretory neurons correlation index - a stable population against the background of a long-term stage-by-stage observation after a single exposure to the DU.