Current State of Human Melioidosis Serodiagnostics
This analytical review is devoted to matters of human melioidosis serodiagnostics and prospects of its development and enhancement. Materials of the publications cited reflect particular significance of the specific antibody detection, for both the early and retrospective diagnostics of human melioidosis, as well as for the correct treatment of patients. Summarized are the data on modern approaches to the selection of serodiagnostics methods in the endemic and non-endemic areas, on the advantages and limitations of the most widely applicable methods for the specific antibody detection (indirect hemagglutination test and solid-phase ELISA). In recent years, development of commercially available enzyme-linked test systems for the detection of antibodies to human melioidosis agent has become an object of intense interest, as this will provide for solid-phase ELISA implementation into the laboratory practice for early detection of melioidosis cases in humans.