PREVALENCE OF VARIOUS HUMAN PAPILLOMAVIRUS GENOTYPES IN CERVIX UTERI DISEASE
Objective. To study the incidence of high-risk human papillomavirus (HPV), its genotype spectrum, and load. Subjects and methods. Molecular biologically studies of cervical canal scrapes were conducted in 773 female outpatients. Results. High-risk HPV was identified in 58.2% of the women. Whether clinical cervix uteri changes were present or absent, HPV type 16 held the lead. HPV type 31 was second most frequent in women without clinical and morphological changes in the cervix uteri, in those with chronic cervicitis and cervical intraepithelial neoplasia (CIN) grade I; and all other detectable high-risk HPV types were encountered in different percentage of cases. In patients with CIN grades II-III, HPV type 33 ranked second. HPV types 51 and 59 were undetectable in CIN grade II and III, respectively. In patients with chronic cervicitis and CIN grade I, the viral load exceeded the progression threshold. As morphological changes worsened, the viral load reduced and was in the upper range of significant concentration in patients with CIN grades II-III.