ESTIMATION OF MEDIUM MOLECULAR PEPTIDES AS A MARKER OF ENDOGENOUS INTOXICATION IN ACUTE BRONCHITIS AND COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN WITH PERINATAL CNS INVOLVEMENT
The aim of the study was a comparative study of the syndrome of endogenous intoxication in acute bronchitis and community-acquired pneumonia in children with perinatal CNS involvement.There were examined 39 children with acute bronchitis aged 6 to 12 years and 87 children aged 6 months to 3 years with community-acquired pneumonia (CAP) and associated manifestations of perinatal CNS involvement. Children with CAP were divided into 2 groups. The I (main) group consisted of 44 children (56.6%) with complicated course of CAP. The II (comparison) group consisted of 43 patients (49.4%) with uncomplicated pneumonia. Along with the generally accepted clinical-laboratory and radiographic examination, the content of medium molecular peptides was determined for all children using the spectrophotometric method of evaluation on the apparatus of KFK 3-01 (Russia).There was found the increase in the content of medium molecular peptides in blood plasma, besides the more well-marked increase was in case of complicated pneumonia in children with perinatal CNS involvement. The obtained results allow considering the deﬁ nition of medium-molecular peptides as an informative criterion for assessing the severity of the course of the pneumonic process in children.