Reaction of 3-Amino-4,6-diarylthieno[2,3-<i>b</i>]pyridine2-carboxamides with Ninhydrin
The reaction of N -substituted amides of 3-amino-4,6-diarylthieno[2,3- b ]pyridine-2-carboxylic acids with ninhydrin in the presence of catalytic amounts of sulfuric acid gave 1'-spiro[indene-2,2'-pyrido[3',2':4,5]thieno[3,2- d ]pyrimidine]-1,3,4'(3' H )-triones. Structure of a number of key compounds was studied using 2D NMR spectroscopy; the bioavailability parameters of the obtained compounds in silico were calculated. In a laboratory experiment, a moderate antidote effect was revealed with respect to the 2,4-D herbicide for one compound.