Vitamin D deficiency as a pathogenetic factor of impaired reparative tissue regeneration of the prosthetic bed
Scientific interest in the problem of the combined course of oral diseases and vitamin D deficiency is based primarily on finding the effect of the systemic effects of vitamin D deficiency on the occurrence, course and outcome of inflammatory processes in the oral cavity, including the frequency of the inflammatory reaction after prosthetics with laminar dentures.Materials and methods. The scientific literature suggests that impaired immune and cytokine homeostasis, including vitamin D-associated deficiencies, can lead to impaired reparative tissue regeneration of any localization, including the cavity. These facts can be considered as10 • СОВРЕМЕННАЯ СТОМАТОЛОГИЯ • N1 2019Проблемные статьи и обзорыa basis for the development of new ways of differentiated therapy of oral diseases. The issues of the formation of therapeutic tactics for dental diseases of a character with regard to vitamin D deficiency remain the subject of scientific discussion and relate primarily to the risk of developing oral squamous cell carcinoma. Proved the important role of vitamin D in the regulation of proliferation and differentiation of oral mucosa cells.Conclusion. Analysis of the scientific literature is a convincing argument in favor of the feasibility of continuing scientific research on deciphering the pathogenetic features of inflammatory diseases of the prosthetic bed in vitamin D-deficient orthopedic patients, which may allow developing new methods of preventing and treating inflammatory diseases of the prosthetic bed in such patients.