URINE PROTEOMIC PROFILES AND QUALITY OF SELF-CONTROL IN PEDIATRIC TYPE 1DIABETES MELLITUS
Introduction. Numerous clinical studies have demonstrated that the improvement of glycemic control causes a signiﬁcant reduction of the risk of micro- and macrovascular complications of diabetes mellitus, particularly the development of diabetic nephropathy.Aim of the study was to investigate the eﬀect of the quality of self-control in pediatric type 1 diabetes mellitus on the functional state of the nephron, determined by the urine proteomic proﬁle.Methods. It were examined 308 patients with type 1 diabetes mellitus dividing into four groups depending on the quality of self-control (regularity of insulin administration, glycemic control, compliance with diet and exercise regimen): from dissatisfaction to the excellent quality of self-control. Uroproteinograms were studied using automated electrophoresis method in gradient polyacrylamide gel (8-25%).Results and conclusion. The favorable eﬀect of good self-control on diabetes was conﬁrmed: an inverse correlation was established between self-control and the level of glycemia, lipidemia, mean blood pressure, the presence of proteinuria in common urine analysis and etc. At the same time, analysis of the uroproteinogram in patients with type 1 diabetes mellitus didn’t reveal any diﬀerences in the protein proﬁle of urine, depending on the level of control. The performed investigation of the nephron state conﬁrms the possibility of the development of diabetic nephropathy even with excellent self-control.