SEARCH FOR NEW WAYS TO DIAGNOSE FOOD ALLERGIES AND FOOD INTOLERANCE IN CHILDREN
Recent studies have shown that up to about 20 % of the population have the FUT2 gene inactivated as a result of mutations, which leads to a «non-secretant» phenotype, and as a result, structures carrying the H antigen are not synthesized on the epithelial surfaces of mucous membranes and are absent in the milk of mothers who are «non- secretant» . Changes in the expression of the H antigen provoke allergic reactions and reduce the intraspecific diversity of the intestinal microbiota. Saliva is an accessible biomaterial, contains many biomarkers, which expands the prospects for its use to clarify the degree of intestinal dysbiosis, and allows you to control the dynamics of the course of the disease. The aim of this study was to study the level of volatile fatty acids (VFA) in saliva and feces in children of the «non-secretant» phenotype with a verified diagnosis of food allergy (PA). Differences in the qualitative and quantitative changes in the composition of microflora are shown both in children with «non- secretant « and «secretant « phenotypes, and in their mothers. The data obtained in children of the «non-secretant» phenotype allowed us to consider changes in the amount of metabolic products as important factors of dysbiosis of the mucous membranes of the oral cavity and intestines. More pronounced disturbances in the microbiota of the oral cavity and intestines in mothers of children of the «non-secretant» phenotype could create prerequisites for changing the child’s immune homeostasis and negatively affect the formation of the intestinal microbiota.