Organization of hematologic care in armed forces: focus on differential diagnosis of eosinophilia
The principles of differential diagnosis, treatment algorithms, depending on the shape of eosinophils, eosinophils, and risk factors for complications are presented. Increasing the absolute number of eosinophils in the blood >0,5×109/L is called eosinophilia. Eosinophilia of blood accompanied by many diseases. This phenomenon threatens the development of hematological patients with hypereosinophilic syndrome, a condition characterized by end-organ damage eosinophilic infiltrates. In this regard, it is necessary in the early stages to eliminate the cause of eosinophilia. There are four еtiopatogenetics types of eosinophilia: non-neoplastic secondary/reactive, paraneoplastic secondary, primary/myeloproliferative, idiopathic. The basis of secondary eosinophilia is hyper production of cytokines that affect eosinofilopoesis that occurs in various diseases (parasitic invasion, allergies, solid cancers, etc.). Primary eosinophilia characterized by abnormal myeloid clone, which leads to increase of blood eosinophilia. Idiopathic eosinophilia is considered when another cause not established. The main problem of this condition is early differential diagnostic causes. Tоday diagnostic criteria, which would allow suggest the possible direction of diagnostic actions in early stages of the patient disease to secondary or clonal (hematologic eosinophils) is absent. In this work we show the basic principles of differential diagnostic of eosinophilia, including early identification of its type. The basic principles of differential diagnosis of eosinophilia, including early examination of the patientare described. We considered pathogenic variants of eosinophils in various diseases, iatrogenic effects.