MORPHOLOGICAL FEATURES OF WOUND PROCESS BURN WOUNDS WHEN USING ALLOGENIC FIBROBLASTS
The article presents a morphological study of burn wounds in 14 burnt miners. Transplantation allogenic fibroblasts was used for stimulation of reparative processes in the burn wound after exci- sion of necrotic eschar. Affected by explosions of methane-coal mixture were treated in the Donetsk burn center in the period from 2009 to 2012. The total area burned in victims was 59,29±5,26% body surface, including deep - 14,07±4,51%. Burn wounds were characterized by a mosaic lesions observed alternation of areas of superficial and deep dermal burns. In biopsies of burn using mor- phometry determined area sections with the newly formed epithelium at 7 and 14 days after trans- plantation allogenic fibroblasts. It was found that the areas of burns, where culture is used allogenic fibroblasts, the average area of the formation of the newly formed epithelium was 6,24±0,26 mm2, while in the control plots the average size of the newly formed layer of the epithelium is 3,66±0,17 mm2. The differences between digital values of the newly formed epithelium square significant at p<0,05 (Mann-Whitney U Test). Application allogenic fibroblasts 1,7 times accelerated the forma- tion of the epithelial layer of the skin areas with preserved regenerative potential in comparison with control plots burn wounds where cellular technology is not applied.