PATHOGENETIC MECHANISMS OF CALCIFICATION OF THE AORTIC VALVE: ANALYSIS OF OWN DATA
Aortic stenosis (AS) remains one of the most common valvular heart diseases despite the improvement of diagnostic techniques and changing therapeutic approaches. Unfortunately, the only radical treatment of AS nowadays is aortic valve replacement. The main reason for the lack of effective drug therapy that could affect the progression of AS are gaps in the understanding of the pathogenic mechanisms of aortic stenosis formation. This review combines the most discussed possible mechanisms of aortic valve calcification in recent years. Also it contains the results of our studies at the Federal Almazov North-West Medical Research Centre since 2010, allowing to estimate the contribution of different links of the pathogenesis to the development of aortic valve calcification.