Cell adhesion molecule expression by phagocytes as a criterion for the differential diagnosis of hypertensive disorders in pregnant women
Objective. To propose new differential diagnostic criteria for arterial hypertension (AH) on the basis of an investigation of cell adhesion molecule expression by venous blood neutrophils and monocytes in pregnant women with different forms of this condition. Subjects and methods. Fifty women with preeclampsia (PE), 36 with chronic AH (CAH), 33 with CAH added by PE, and 45 control women were examined. Flow cytofluometry was used to determine the levels of CD11b <sup>+</sup>, CD49b <sup>+</sup>, CD99 <sup>+</sup> monocytes and neutrophils. Results. As compared to the control group, the patients with PE were found to have elevated CD49b <sup>+</sup> neutrophil levels; those with CAH had higher CH99 <sup>+</sup> neutrophils and lower CD11b <sup>+</sup> monocytes; those with CAH and PE had increased CD99 <sup>+</sup> and CD49 <sup>+</sup> neutrophil concentrations. The examined indicators are of informative value in the differential diagnosis of hypertensive disorders in pregnant women. Conclusion. The determination of the levels of CD11b <sup>+</sup>, CD49b <sup>+</sup>, CD99 <sup>+</sup> monocytes and neutrophils may be used as an additional diagnostic criterion in identifying the type of AH in pregnant women.