N-Alkylation of N-(<i>b</i>-Aminoethyl)Piperazine by Monohalogenated-<i>Gem</i>-Dichlorocyclopentane
Investigated N-alkylation of N-(<i>b</i>-aminoethyl) piperazineethanol-<i>gem</i>-dichlorocyclopentane under thermal heating, leading to the formation of corresponding derivatives of the amino <i>gem</i>-dichlorocyclopentane. It is shown that the yield of alkylation products depends on the direction of the substitution reaction with respect to hydrogen atoms in the primary or secondary nitrogen atom. The corresponding mono substituted N-(<i>b-</i>aminoethyl)piperazine was obtained with high yield. It was found that the reaction rate is determined by the substituent in 2-halomethyl-1,1-dichlorocyclopropane. Physical and chemical characteristics of the obtained compounds were determined.