THE POSSIBLE WAYS OF REPERFUSION PROPHYLAXIS IN CRITICAL CONDITIONS
Th e review covered the analysis of the modern literary data, which suggest that disorders of microvasculature, lying in the basis of the organ dysfunctions in critical conditions, mainly connected with the intravascular hemolysis of erythrocytes, the release of free hemoglobin and its subsequent catabolism to ions Fe2+. It is supposed that in the conditions of massive intravascular hemolysis the lack of a system of binding, transportation and disposal of microelement is formed. Excess of ions Fe2+ with high catalytic activity can have a direct damaging eff ect on the endothelium of capillaries with the development of the syndrome of capillary leakage.