SYNTHESIS AND ANTITUMOR ACTIVITY OF N-SUBSTITUTED FTALILAMID WITH FRAGMENTS TRIAZINE
Results of investigation aimed to the search of the novel anticancer agents among phthalimide derivatives which contains triazine moiety were presented in this article. The reaction of phthalimide with 3-(2-aminophenyl)-6-R-1,2,4-triazine-5(2H)-ones - prospective “scaffolds” with promising potential for chemical modification was studied. It was shown, that mentioned above interactions yielded 2-[2-(6-R-5-oxo-2,5-dihydro-1,2,4-triazine-3-yl)phenyl]-1H-isoindol-1,3(2H)-diones. Structures of synthesized compounds were proved by complex of phy-sicochemical methods, namely NMR - spectroscopy, chromate-mass- and mass-spectrometry. Features of 1H NMR spectra of synthesized compounds were discussed, thus it was shown, that signals of NH - proton of triazine cycle were observed in abnormally low field. It was estimated that synthesized compounds exhibit moderate antitumor action against cells of renal cancer, breast cancer and non-small cell lung cancer.