The influence of the processes of collagen degradation on cardiohemodynamic remodeling in patients with chronic heart failure
Cardiohemodynamic remodeling was studied in 77 patients with chronic heart failure (with a preserved and reduced systolic function) depending on the degradation processes of type I collagen. As a result of the study, in the group of patients with chronic heart failure with reduced systolic function, we revealed a decreased thickness of the posterior wall with an increased level of carboxyterminal telopeptide of type I collagen. In patients with chronic heart failure with a preserved systolic function, regardless of the level of carboxyterminal telopeptide of type I collagen, a reduced velocity of early diastolic filling was observed, which is one of the signs of diastolic dysfunction. In the group of patients with chronic heart failure with a reduced systolic function, a statistically significant increase in the velocity of early diastolic filling was observed with an increased level of carboxyterminal telopeptide of type I collagen.