THE STRUCTURAL PECULIARITY OF <i>ASPERGILLUS FUMIGATUS</i> DURING THE EXPERIMENTAL ASPERGILLOSIS IN THE MICE
It was shown that in variant with hydrocortisone, the level of fungal development in the murine lung of mice was low. We observed the signs typical of hemorrhagic pneumonia. Well-marked inflammatory infiltration was revealed around the fungal hyphal aggregations. In the variant with cyclophosphan the level of development of fungal elements was quite high. However symptoms of pneumonia and inflammatory reaction around the focuses of necrosis were feebly marked. In the first case neutrophils dominated in the cells of immune system, whereas lymphocytes - in the second case. In the experiments with hydrocortisone dual influence of its different doses on the peculiarities of micromorphology, physiology and ultrastructure of A. fumigatus hyphal cells it was revealed. Regarding the thickness of the hyphal cell wall the compared variants didn't differ. Influence of different concentration of conidia of inoculum on width of fungal hyphae was revealed. Mature cells of narrow hyphae synthesized and accumulated moderate quantity of dark globules of storage protein whereas wide - large lipids inclusions. For the hyphal cells in variant with hydrocortisone was typical the curved form which determined by poor development outside of their cell wall of an extracellular matrix, whose presence in the normal state considerable strengthens the rigidity of the cell wall. Extracellular matrix in option with narrow hyphae has been developed poorly, and with wide was absent. Extracellular matrix in the narrow hyphae was poorly developed, whereas it was absent in wide once. We interpret the curved form of the hyphal cells which infected the murine lung tissue after injection of hydrocortisone by poor development outside of their cell walls of an extracellular matrix, whose presence in the normal state considerably strengthens the rigidity of the cell wall. Other morphological phenomenon of poor development of extracellular matrix in variants with a hydrocortisone was the formation of wide hyphal cells. The existence of well-developed extracellular matrix increased the adhesive properties of aspergillus hyphal cells which is important for their active coordinated radial growth in the murine lung tissue. In variants with a cyclophosphan hyphes of the A. fumigatus had the same morphology and ultrastructure: they synthesized moderate quantity of storage lipids and formed well developed extracellular matrix. We have demonstrated the high plasticity of morphological and ultrastuctural features of the studied A. fumigatus strain except for septae and its pore apparatus.