THE ROLE OF INDIVIDUAL PECULIARITIES OF MYELOPOIESIS IN REALIZATION OF LEUKAEMOGENIC EFFECT OF IONIZING RADIATION
In experiments in Vistar rats of heterozygous breeding, individual peculiarities of the marrow granulocyte response to bacterial liposaccharide and the role of these peculiarities in the formation of leukaemogenic and myelodepressive effect of prolonged tritium incorporated beta irradiation were studied. Three types of response to liposaccharide were discovered. Alongside with an adequate response of 72% of animals, in 22% of cases, an extremely high and long response (irritable type) was recorded, in 6% of individuals the response was weak and short (inert type). In the group of animals with adequate response to liposaccharide, smaller leukaemia output was recorded (3,9%, controls 2,8%). Among rats with irritable and inert types of response, increased sensibility to leukemogenic effect of radiation was recorded (leukaemia frequency was 48,9% and 44,4%, respectively). Possible mechanisms of high leukaemogenic effect of irradiation in animals with inadequate myelopoiesis response to stimulus are discussed. Key words: noninbred rats, bone marrow, granulocyte, bacterial liposaccharide, types of response, chronic radiation exposure, leukaemia, hypo/aplasia.