Assessment of the diagnostic value of some tumor markers and cytokines in breast tumors
Aim. To investigate the sensitivity, specificity and diagnostic value of tumor markers CA 15-3, CEA and some cytokines (IL-2, IL-6, IL-8, IL-10, TNF-α) in patients with breast tumors (benign and malignant neoplasms). Materials and methods. We studied 92 patients aged 18-79 years who were examined for breast cancer. Of the examined patients, malignant tumors were detected in 48 women, and benign breast tumors in 28. 16 practically healthy women were included in the control group. In the blood of all women in the study, serum levels of CEA, CA 15-3 tumor markers and the main pro- and anti-inflammatory cytokines (IL-2, IL-6, IL-8, IL-10 and TNF-α) were studied by enzyme immunoassay analysis. Results and discussion. When assessing the malignancy of a breast tumor, the sensitivity of CA 15-3 was 93.8 ± 3.5%, specificity 89.3 ± 5.8%. For CEA, these parameters were 89.6 ± 4.4% and 78.6 ± 7.8%, for IL-2-70.8 ± 6.6% and 60.7 ± 9.2%, for IL-6-85.4 ± 5.1% and 82.1 ± 7.2%, for IL-8-85.4 ± 5.1% and 78.6 ± 7.8%, for IL-10-60.4 ± 7.1% and 78.6 ± 7.8%, for TNF-α - 56.3 ± 7.21% and 82.1 ± 7.2%, respectively. Conclusion. It was revealed that with breast cancer, the tumor marker CA-15-3 has a high diagnostic value, IL-6 and IL-8 had the highest sensitivity. It can be concluded that these laboratory parameters can play an important role in the study of pathogenetic pathways of development in the diagnosis and monitoring of breast cancer.