CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD): CLINICAL AND IMMUNOLOGICAL EFFECTS OF VACCINATION AGAINST RESPIRATORY INFECTIONS
About 30% of COPD exacerbations are due to viral infections, and influenza A and B viruses are among the most common causes. The aim of the study is to assess the exacerbation rate, the number of courses of antibiotic chemotherapy, and immunological effects of mono vaccination with a new immunoadjuvant influenza vaccines vs. combined vaccination against pneumococcal infection, Haemophilus type b infection, and influenza in COPD patients. Both complex vaccination against S. pneumoniae, H. influenzae type b, and influenza and mono vaccination with a new immunoadjuvant influenza vaccine lead to statistically significant reduction in the number of COPD exacerbations and the number of courses of antibiotic chemotherapeutic agents. The study represents the immunogenicity of the new influenza immunoadjuvant vaccine administered as monovaccine to COPD patients in accordance with СРМР requirements.