ESTIMATION OF INDICATORS OF MORPHOGENIC PROTEINS OF WNT-SIGNAL WAY (SCLEROSTIN AND p-CATENIN) IN PATIENTS WITH CORONARY HEART DISEASE
To date, cardiovascular diseases remain one of the most pressing problems of modern medicine, due to their prevalence and high mortality, including among young and middle-aged people. The search for possible early markers of the development of cardiovascular complications led to an interest in studying the main WNTproteins - the signaling pathway (one of the intracellular signaling pathways that control the phenotypic modulation of vascular smooth muscle cells in cardiometabolic diseases) of sclerostin and f-catenin among patients with coronary heart disease. The article presents data on the quantitative blood serum content of patients with coronary heart disease, f-catenin and sclerostin, describes the relationship of changes in the level of morphogenic proteins of the WNT signaling pathway with clinical and laboratory data, as well as indicators of the structural and functional state of the heart and intracardiac hemodynamics. Understanding the new aspects of the pathogenesis of cardiovascular diseases leading to arterial calcification and cardiac muscle hypertrophy is extremely important for developing new therapeutic strategies aimed at reducing the frequency of cardiovascular complications, as well as reducing the economic costs of treatment and, in general, increasing the life expectancy of patients.