USING THERAPEUTICALS FOR SWINE HEPATOCYTIC ULTRASTRUCTURE AFFECTED BY DIOXINE, T-2 TOXIN
Basing on processes and substances alien to biosphere is a drawback ofthemostcurrenttechnologies. Some of the toxicants are known as dangerous mutagens and oncogens. It is also known that their affect often strengthens at associated exposure on biological entities. In this regard investigation of the way associated introduction of dioxin and T-2 toxin influences on mammal organism on ultrathin level is of high scientific interest.The aim of our investigations was the study of associated effect of dioxin and T-2toxin as contaminants of different groups on swine hepatocytic ultrastructure separately, in associated way, and along with using zeolite and dimephosphone.For this purpose the piglets of Yorkshire breed were divided into 8 groups. For chronic oral challenge dioxin was used indosage of LD1/400, 1/600, 1/800 and T-2 toxin was 2-fold MAC (maximum allowable concentration) level during 45 days.One group of animals was additionally introduced 15-% solution of dimephosphone (immunomodulator and stabilizer of cellular membrane) and zeolite absorbent in 2% per diet ratio.The investigation results showed that associated exposure of ecotoxicants cause considerable alteration of hepatocytes ultrastructure.