Formation of the list of genes, functioning in human blood cells involved in atherogenesis and metabolism of high density lipoproteins
To study the molecular mechanisms of atherogenesis and the athero-protective role of HDL on the transcriptome level, a search for genes involved in these processes has been carried out. 947 differentially expressed genes were revealed as a result of bioinformatic analysis of gene expression in peripheral blood of patients with coronary artery stenosis using data (GSE20129, GSE12288, GSE10195, GSE20686) from GEO, the database of genome-wide studies. Of these, it has been selected 66 genes associated with atherosclerotic coronary ar-tery disease, underlying coronary heart disease (CHD) and myocar-dial infarction. To this list, it has been added the genes for which the association with coronary artery atherosclerosis was determined by the authors themself using bioinformatic algorithms (19 genes) or RT-PCR (67 genes), as well as 21 genes involved in HDL metabolism according to Reactome database. Analysis of the combined gene list revealed that 60 of them is involved in biological processes related to lipoprotein and lipid metabolism, reverse cholesterol transport and inflammation. We suggest that the genes found are involved in HDL metabolism and atherogenesis in patients with CHD. Evaluation of their differential expression in human peripheral blood cells can be used for further study the molecular mechanisms of coronary artery atherosclerosis and the atheroprotective role of HDL.