Plasmatherapy in Aesthetic Medicine. Optimal parameter choice for Obtaining Enriched Autoplasma
Autoplasmotherapy is widely used in injectable cosmetology to correct involutive skin changes. However, there are some certain difficulties associated with the standardization of the obtaining process, ensuring the safety and making it more effective. The maximum benefit is achieved through the activation of platelets and the release of growth factors contained in their a-granules. Materials and methods. The article examines the results of a laboratory study, which covers centrifugation parameters for whole autografts, which will ensure the maximum platelet content in the plasma and their activation. In a subsequent clinical study an evaluation of the efficacy of autologous plasma (obtained on the optimal centrifugation parameters determined at the first stage) in combination with the enrichant (HYALREPAIR-PRP matrix gel) in 25 patients with involuntive skin changes was performed. The evaluation of efficacy was carried out taking into account the qualitative characteristics of the skin (elasticity, hydration) according to epiluminescence microscopy. The results of the study. As the optimal mode has been approved primary centrifugation at 3000 rpm for 10 minutes, in which there are morphologically unchanged whole platelets in the autoplasma at a maximum concentration of 1500 in 1 ml, a regimen of 10 minutes centrifugation at 3500 and 4000 rpm at which a picture of a uniform destruction of platelets was obtained. The developed technique for obtaining autoplasma with activated platelets and subsequent intradermal injection of this autoplasma combined with the enrichant allows to obtain significant clinical results in involutive skin changes.