Effective annual chronoterapy ACE inhibitor (lisinopril) in patients with arterial hypertension under the conditions of circumpolar shift work
We studied under conditions of the Extreme North on the basis of Medical Unit “GAZPROM DOBYCHA YAMBURG” 93 males at the age from 20 till 59 years, mean age 45,8 ± 6,9 years. The results of 12 - month study of 93 males with 1, 2 degree AH treated with chronotherapy and treated with usual antihypertensive therapy ( lisinopril 5 mg \ day ). 24-hour ambulatory blood pressure monitoring (ABPM) was performed in all patients, individual cosinor-analysis with the definition dironotype circadian rhythm of BP. In therapy used chronotherapy approach, which includes the method of preventive chronotherapy and method of “pacing”. The study showed that under the conditions of circumpolar shift work mainly atypical chronotype BP (50 % of evaluable patients), which leads to the importance chronocorrection therapy of AH. Chronotherapy interventions under the conditions of circumpolar shift work for a year has a pronounced hypotensive and chrono stabilizing effects.