Dynamics of spontaneous peripheral blood basophil activation in response to toothpastes in children with allergic diseases
Objective. To analyze the dynamics of spontaneous peripheral blood basophil activation in children allergic to toothpastes. Patients and methods. The study included 94 patients aged between 3 and 10 years. Study participants were divided into two groups: Group 1 included children with a history of allergic reactions (n = 47), whereas Group 2 comprised children with no allergic reactions in the past (n = 47). The intensity of caries was comparable in both groups. In order to determine tolerability of toothpastes, all children underwent antigen-induced basophil activation test using the flow-CAST method. Results. We found that toothpastes R.O.C.S. BABY «Chamomile», R.O.C.S. «Active Calcium», and R.O.C.S. PRO «Young & White Enamel» did not cause significant activation of basophils in peripheral blood (within the reference range) in children ages 3 to 10 years with allergic diseases. Conclusion. These toothpastes can be recommended for children with allergic diseases.