The prevalence of polymorphisms of cytochrome P-450 genes and transporter genes of proteins in Russian population and in three ethnic groups of the Republic of Dagestan
Introduction. Trials which had been performed for various ethnic groups have shown marked interracial and interethnic differences in drug sensitivity. The greatest clinical significance belongs to the genes encoding liver enzymes of cytochrome P450 (CYP2C9, CYP2D6, CYP2B6, CYP3A4, CYP3A5 and CYP2C19) as well as the genes encoding transport proteins (ABCB1 and SLCO1B1), which are associated with changes in pharmacological effects in a number of drugs prescribed for cardiovascular pathologies. ISSN 1818-460X. Кремлевская медицина. Клинический вестник. № 1, 2017 Распространенность полиморфизмов генов системы цитохрома Р-450... To study the prevalence of polymorphic markers of genes CYP2C19, CYP2C9, CYP2D6, ABCB1 and SLCO1B1 among representatives of three ethnic groups in Dagestan and compare it with Russian population in Moscow region who are carriers of these markers. Materials and methods. 186 healthy volunteers representatives of three ethnic groups from the Republic of Dagestan (46 Laks, 90 Avars and 50 Dargins) were taken into the study. PCR in real time was used for determining gene polymorphisms. Results. While comparing the allele frequency in Russians and in the three ethnic groups from Dagestan a statistically significant difference was found in the following gene polymorphisms: GYP2C19*17 frequency in Russian population (27.3%) was higher as compared to Avars (20%); GYP2G9*3 frequency was lower in Russians (6.7%), while among Avars, Dargins and Laks it was 19.57%, 17% and 15.5 %, correspondently. ABCB1 frequency was higher in Laks, and it was equal to 68.48% vs. 54.3% in Russians. SLCO1B1*5 frequency was higher in Russian (21.8%), while in Avars, Dargins and Laks it was 14.4%, 10% and 9. 78%, respectively. Conclusion: Findings obtained during the present trial with pharmacogenetic testings on gene polymorphisms of CYP2C19*2, *3, *17, CYP2C9*3, CYP2D6*4, SLCO1B1*5, ABCB1 in three ethnic groups from the Republic of Dagestan are considered to be useful for optimizing pharmacotherapy of cardio-vascular diseases.