Level of heavy chains of neurofilaments, amyloids 1-40 and 1-42 in cerebrospinal fluid of patients with opticomyelitis and multiple sclerosis
Neuromyelitis optica (NMO) can lead to persistent disability in a short period of time. Persistent neurological deficit in demyelinating disorders is determined by neurodegeneration. As has been shown earlier neurodegeneration is characterized by changes in enzymes activity and shifts in b- amyloid levels. The aim of our study was try to check are there any difference in neurodegeneration of NMO and Multiple Sclerosis (MS) according to b-amyloid 1-40 and 1-42 levels in cerebrospinal fluid. Method. B-amyloids 1-40 and 1-42 were measured by an enzyme-linked immunosorbent assay in patients with MS (n = 52), NMO (n = 5) and control group (n = 26). Results. There was not any difference between NMO and MS (exacerbation). Level of b-amyloid 1-42 was higher in MS remission group than in NMO, but the same difference was detected between remission and exacerbation MS groups.