VITAMIN D AND ZINC LEVELS COMPARATIVE CHARACTERISTICS OF PATIENTS WITH ISOLATED AND COMBINED CHRONIC OBSTRUCTIVE PULMONARY DISEASE
The article is devoted to comparative characteristics of the zinc and vitamin D levels state issues in patients with isolated COPD and in combination with other diseases (chronic laryngitis and residual fibrous changes in the lungs after clinically cured pulmonary tuberculosis). Comorbidity is an urgent problem of modern medicine. Many diseases have common risk factors and mechanisms of development. Currently, the presence fact of a respiratory system continuum is no longer disputed, therefore, risk factors and mechanisms for the development of chronic obstructive pulmonary disease comorbidity and other diseases of the respiratory system (upper respiratory tract and lower respiratory tract) may be identical and require detailed study. The aim of the study was to compare vitamin D levels and serum zinc levels in patients with isolated and combined course of chronic obstructive pulmonary disease with chronic diseases of the respiratory system. Materials and methods of research. The authors analyzed the zinc and vitamin D concentration in 3 groups: 1 - with isolated COPD, 2 - COPD in combination with chronic laryngitis and 3 - COPD in combination with residual fibrous changes after clinically cured pulmonary tuberculosis. The results of the study indicate the presence of the trace element zinc and vitamin D deficiency, which is a feature of the comorbidity manifestation of chronic obstructive pulmonary disease. Conclusions. Patients with both combined COPD and chronic laryngitis and isolated COPD have zinc and vitamin D deficiency. In patients with COPD and residual changes in the lungs in the form of fibrosis after cured pulmonary tuberculosis, vitamin D and zinc deficiency is also determined. Serum zinc and vitamin D levels are significantly lower in comorbid pathology compared to isolated COPD, which reflects their mutual influence and increases the risk of exacerbation of diseases. The inverse dependence of zinc and vitamin D levels on the values of FEV1 requires further research: the dependence study on the frequency of exacerbations of COPD, the smoker's index and other indicators.