Molecular genetic predictors of protrombotic status in children
We investigate the prevalence of the genetic variants related to thrombophilia among children with acute ischemic stroke (AIS, n=35) compared with children who were born by women with thrombophilia markers (n=71). We researched those patients for 7 single nucleotide polymorphisms (SNPs) of thrombophilia and folic acid cycle’s enzymes studying. The incident of severe thrombophilic SNPs (FGB: -455G>A, F2: 20210G>A, ITGA2: 807C>T, PAI-1: -675 5G>4G, MTHFR: 677С>Т, MTHFR: 1298А>С, MTRR: 66А>G, MTR: 2756А>G) was higher among the children with the AIS. Neonates who were born by women with thrombophilia markers are at risk of acute thrombotic diseases in the future.