SYNTHESIS AND HYDROGENIZATION OF NEW 3-METHOXYMETHYL- 4-NITROSO-5-PHENYL-1H-PYRAZOLE
Pyrazole derivatives are broadly used as pharmaceuticals. Analgin, amidopyrine, antipyrine and other classic pyrazole-based remedies are broadly used in the pharmacology. According to the literature of derivatives pyrazoles are compounds that exhibit fungicidal and antibacterial activity. In this paper we present data on the synthesis of previously unknown 1-phenyl-4-methoxybutane-1,2,3-trione-2-oxime by nitrosation with sodium nitrite in acetic acid 1-phenyl-4-methoxybutandion-1.3. By reacting 1-phenyl-4-methoxybutane-1,2,3-trione-2-oxime with hydrazine hydrate in an aqueous alkaline medium has been synthesized previously available 3-methoxymethyl-4-nitroso-5-phenyl-1H-pyrazole. Hydrogenization of nitrosopyrazole by hydrazinehydrate in dichloromethane on the catalyst Pd \ C 0.5 % was first allowed to allocate 3-ethoxymethyl-4-amino-5-phenyl-1H-pyrazole. Individuality of synthesized compounds is confirmed by thin layer chromatography. The structure of the synthesized compounds is proved by modern physical methods: UV, NMR, IR spectroscopy.