ENDOTHELIAL DYSFUNCTION AS THE MOST IMPORTANT PATHOGENETIC FACTOR IN THE DEVELOPMENT OF CRITICAL CONDITIONS
The study aims to consider the main functions of endothelium in the regulation of vascular wall permeability in critical conditions, as well as humoral factors affecting the state of the endothelium. Material and methods. In the course of the study, 38 sources were selected for the literary review out of 350 scientific publications obtained from various databases (Scopus, Web of Science, PubMed, RSCI). Results. The review details the role of the most important etiological and pathogenetic factors in the formation of endothelial dysfunction and the significance of endothelial damage in the pathogenesis of various pathological processes and conditions caused by both chronic diseases and disorders and acute processes.