THE LATEST DATA ON THE ROLE OF NEUROGENIC INFLAMMATION AND ITCHING IN THE PATHOGENESIS OF CHRONIC SPONTANEOUS URTICARIA (LITERATURE REVIEW)
Chronic spontaneous (idiopathic) urticaria is a disease with a complex pathogenesis. The prevalence of dermatosis has been increasing over the past decades, especially in children. Clinical manifestations of urticaria are accompanied by debilitating itching, which significantly worsens the quality of life of patients, disrupting sleep, performance and mental state. The recent identification of a new MRGPRX2 receptor of mast skin cells has opened up the possibility to study the role of neurogenic inflammation in the mechanism of chronic spontaneous urticaria. Taking into account the ability of the neuropeptide of substance P to interact with isolated receptors and induce the activity of mast cells, the study of this process allows us to expand the understanding of the pathophysiology of this disease.This work is based on the study of works devoted to new aspects of the pathogenesis of chronic spontaneous urticaria and its connection with neurogenic inflammation. An analysis of the literature on the issue under study indicates a significant role of the neuropeptide substance P in the degranulation of mast cells. Due to the identified MRGPRX2 mast cell receptors, the role of neurogenic inflammation and itching in the pathogenesis of chronic spontaneous urticaria is beyond doubt.