DEVELOPMENT OF ADJUVANTED-FREE CHRONIC BRONCHIAL ASTHMA MODEL IN MICE
Bronchial asthma (BA) is a common chronic inflammatory disease of the airways. To elucidate the pathophysiology of this disease and to test new drugs most commonly used adjuvant acute asthma models. However, the acute models are short-term and the use of adjuvant does not allow test adjuvant-containing drugs. Therefore, the purpose of this study was to develop adjuvant-free model of chronic asthma in mice. To produce BA phenotype in mice we used subcutaneous sensitization with allergen that led to develop crucial BA features such as Th2 prevalence of immune response, high level of allergen-specific IgE antibodies, infiltration of inflammatory cells to the lung tissue and airway remodeling.