Study of antihistaminic and sedative effects of Histafen in patients with allergic rhinoconjunctivitis
Histamine contributes to the development of almost all common symptoms of allergy by stimulating H1 receptors. Thus, antihistamines are commonly used to treat allergic disorders. Quinuclidin derivatives (Phencarol and Histafen) uniquely combine the advantages of the 1st- and 2ndgeneration antihistamines. In the described study of patients with allergic rhi noco njunctivitis, Histafen significantly reduced the blister's size and decreased skin hyperemia caused by histamine and specific allergen. Histafen also significantly reduced the overall index of the symptoms. Histafen showed no evidence of sedation which was demonstrated in the absence of changes in the indices of the volume and stability of con - centration before and after treatment.