FREQUENCIES OF HYPERMETHYLATION OF PROMOTER AREAS OF GENESSUPPRESSORSIN PATIENTS WITH BREAST CANCER
In the article there are the results of molecular-genetic analysis of hypermethylation of promoter areas of 9 genes-suppressors: RASSF1A, HIN1, DAPK, APC, Cyclin D2, RARβ, GSTP1, p16 and hMLH1 in the group of 82 patients with a diagnosis of breast cancer. It was shown that hypermethylation by at least one gene is available in 90,2% of breast cancer cases. The most informative were found to be 5 out of 9 analyzed genes: RASSF1A, Cyclin D2, APC, RARβ, and DAPK that help to consider them as candidates for forming of diagnostic marker panel. By the number of genes there was determined the significant association of frequencies of hypermethylation with clinical-morphological characteristics of breast cancer.