AN OVERLAP BETWEEN SPLICING SITES IN pre-mRNAsAND HOMO-REPEATS IN HUMAN PROTEINS
To answer the question of whether some splicing sites in pre-mRNAs may be attributed to homo-repeats in human proteins, we examined proteins with homo-repeats with a length of more than 4 amino acid residues. Human proteome contains a total of 404 proteins with homo-repeats, which account for at least one splicing site in pre-mRNA. We show that pre-mRNA splicing sites are more often found in the C-terminal part (67%) than in the middle or the N-terminal part of the homo-repeats. In ten different homo-repeats we found two splicing sites per repeat. In all cases except one, these repeats were lysine homo-repeats.