CORRELATION BETWEEN SOME GROWTH FACTORS AND HORMONES IN BLOOD OF RATS DURING LIVER METASTASIS
Studying the mechanisms of neoplastic transformation of cells is one of the most important oncology problems. Understanding the processes underlying transformation of a normal cell into a tumor one is the basis for search for new methods of cancer therapy. The article analyzes correlation between some hormones and growth factors on the developed model of liver metastasis in rats eliminating toxic effects of carcinogens, acute operational impact and anesthesia. IGF-I, IGF-II and ТGF-β1 were found to have twice less strong correlations with hormones in blood serum in liver metastasis than during primary tumor growth. IGF-I came to the fore with its 7 strong correlations, including positive ones – with ACTH, DHEA, estradiol, prolactin, TSH and free thyroxine and neg-ative ones – with estrone. Two other factors had 2 strong correlations each: IGF-II – positive ones with cortisol and FSH, ТGF-β1 – negative ones with cortisol and testosterone. Moreover, ТGF-β1 correlations were mainly moderate negative ones and IGF-II correlations were weak. Thus, liver metastasis is accompanied by the devel-opment of a more complex system of unbalanced hormonal influences on tumor growth which indicates modifi-cation of hormonal regulation of metastasis processes combined with IGF-I and ТGF-β1 expression in the liver.