Use of food products with probiotic properties in treatment and prevention of impaired microbiocenosis in children
The objective. To assess the effectiveness of using probiotic therapy in treatment of impaired intestinal microbiocenosis. Patients and methods. The examination included 45 children aged 5 to 12 years (basic group), who received a course dose -14 portions of BI (5.6 х 10 <sup>8</sup> CPU of BB). The control group comprised 46 children. Results. Against the background of intake of BI, unlike in the control group, we have noted an increase of the number of patients with normal levels of anaerobic flora - BB (odds ratio - OR = 2.13, CI = 0.51-7.84), LB (OR = 1.54, CI = 0.42-5.27), peptostreptococcus (OR = 2.24, CI = 0.38-10.72), the number of children with the presence of conditionally pathogenic flora in faeces decreased - E. coli typical (lacto+) (OR = 8.00, CI = 0.86-38.1), E. coli typical (lacto+) with lower fermentative properties (OR = 3.33, CI = 0.35-19.36). In the control group, the number of samples with normal levels of BB and LB., saprophytic epidermal streptococci decreased. After intake of a dietetic product, bacteria occurring in single cases were completely eradicated - they were это Streptococcus pyogenes, Moraxella catarrhalis, Corynebacterium minutissimum, Corynebacterium paurometabolum, Acinetobacter woffii. Also, fungi of the genus Candida disappeared completely, the incidence of Streptococcus agalactiae decreased almost by 2 times. But the number of grown specimens of Streptococcus equi and Streptococcus porcinus increased significantly. In the control group, there was a natural dynamic of microbial flora of the oropharynx - a significant decrease of Staphylococcus aureus and Streptococcus agalactiae, sanation of the oropharynx from Streptococcus equi, Streptococcus pneumoniae. On the other hand, the number of smears with positively grown fungi of the genus Candida statistically significantly increased more than by 3 times. Conclusion. The use of BI in children does not lead to development of side effects, does not enhance dysbiotic impairments in the intestines, partially sanitizes and does not disturb the microbial composition of the oropharynx.