THE PLACE OF MODERN ENTEROSORPTION IN ALCOHOLIC LIVER DISEASE TREATMENT AND PREVENTION (LITERATURE REVIEW)
Alcoholic liver disease is one of the most urgent pathologies in gastroenterological practice. In severe cases, it affects not only the liver, but also the kidneys, the central nervous system, the mucous membrane of the gastrointestinal tract. Often there is the addition of bacterial complications. An important role in the pathogenesis of alcoholic liver damage is played by the translocation of lipo-polysaccharides through the intestinal wall. Bacterial endotoxin is an additional stimulator of the production of pro-inflammatory cytokines that cause damage to target cells with the development of the picture of multiorgan failure. This makes it important to use drugs that help restore the integrity of the enterogematic barrier and prevent excessive intake of endotoxin (lipopolysaccharide) into the blood. The article presents the results of studies confirming the feasibility and effectiveness of the use of enterosorbents, in particular polymethylsiloxane polyhydrate, in the treatment of alcoholic liver disease.