POLYMORPHISM A154C OF CYP1A2 GENE AND RISK OF DEVELOPMENT OF ESSENTIAL HYPERTENSION. ANALYSE OF ASSOSIATION AND RELATIONS WITH ENVIRONMENTAL RISK FACTORS
The purpose of this study was to investigate if the common polymorphism is A154C of CYP1A2 gene associated with susceptibility to essential hypertension (EH) in Russian population of Central Chernozem region of Russia, to determine the role of environmental risk factors in realization of EH predisposition in this gene genotypes carries. The blood samples of 560 patients with EH and 480 sex- and age-matched healthy individuals were used to determine gene polymorphisms. Polymorphism A154C of CYP1A2 gene was genotyped using real-time polymerase chain reaction (PCR) analysis. Statistically significant association was observed between the allele frequency and essential hypertension in the group of women with EH. Heterozygous and mutant genotypes can be considered as genetic risk factor for development of EH, depending of environmental factors associated with high risk to develop EH.