The studying of phenotypic activity of CYP3A4 in children with acute allergic urticaria
The acute allergic urticaria takes the leading place in the structure of all allergic pathology in children. The priority means for control of clinical symptoms are antihistamin urticaria herbal means metabolizing in the organism with participation of enzyme CYP3A4. Phenotypic activity of CYP3A4 depends on pharmacocynetic parameters of antihistamin means, their effectiveness and security. 30 children with acute allergic urticaria were observed, 40 - conditioned healthy children.The definition of phenotypic activity CYP3A4 was made according to study of correlation 6-β-hydroxycortizol to urine cortizol. The investigation of phenotypic activity CYP3A4 in children with acute allergic urticaria gave the possibility to find out statistic real suppress of enzyme activity in comparison with conditioned heaithy children in the group of children from 0 to 3 years and in the group of children from 4 t0 9 years, it way explain the age physiological non-maturity of enzyme system of liver and additional waste CYP3A4 on metabolism of xenobiotics appeared in acute allergic reaction. The usage of antihistamin means of the first generation in these age groups must be done with minimal therapeutic dose.