CORRECTION OF A TOXIC HEPATOSIS AT THE DOGS, CAUSED BY INFLUENCE OF MACROCYCLIC LACTONES
In the treatment and prevention of parasitic diseases such as arahnsis, entomosis and nematosis animals are widely used macrocyclic lactones, whose role is undeniably great. However, their assignment to small pet is often contributes to the development of liver disease. In such circumstances, one of the urgent problems of modern veterinary pharmacology is the development of environmentally safe and effective medicines that prevent negative side effects as the macrocyclic lactones, and other drugs. The great interest in this direction is the development of new le-regulatory authorities, based on the terpenoids of plant origin and their synthetic analogs. The article presents new data demonstrating the presence of hepatoprotective properties of the drug composition of the OmeCT CA+Аnilocainum+Polifloxacin in a ratio of 1:2:0,2. It is shown that a seven-day course of prescribing OmeCTCA+Аnilocainum+Poliflo xacin (1:2:0,2) a dose of 25 mg/kg completely prevents the formation of hepatotoxic effects in a health care appointment macrocyclic Lactone - ivomek, in dogs. At the same time morphological and biochemical indicators of a blood and the level of organ-specific markers that characterize the cytolysis of hepatocytes did not differ from a physiologically acceptable.