PRECLINICAL STUDY OF THE TOXICOLOGICAL PROPERTIES "ANTIADHESION GEL"
Conducted research on the study of acute toxicity anti-adhesion gel. The experimental studies were conducted in accordance with the rules of laboratory practice of GLP.The study was conducted on laboratory animals - on 30 mature nonlinear white mice weight 24,0 – 25,0g., 2,5 – 3 months of age of both sexes. The study of the acute toxicitycarried out by the method of Litchfield J. and Wilcoxon F.The observation was conducted over two weeks, set limits of acute toxicity. Identify the class of toxicity of the gel in accordance with the classification.Proved that an antiadhesion gel after intragastric administration to mice at the maximum allowable volumes not cause death of animals in early and long-term follow. LD50antiadhesion gelamounted to 32,0 ml/kg.