Urokinase Plasminogen Activator in breast tumors
The comparative values of immunoenzyme determination of urokinase-type plasminogen activator (uPA) in cytosol of tumor cells of 248 breast cancer patients are presented. Patients with 31% malignancy (T0N0M0) 76 and with 69% malignancy (T2N0M0) 172. It was revealed that levels of uPA in patient tumor tissues were reliably higher than values in non-afflicted parts of the same tissue. The uPA (concentrations were higher in share infiltrated breast cancer, than that in running type in both T1N0M0 and T2N0M0 stages of disease. The most higher uPA values were observed in patients with third stages of malignancy. Nevertheless reliable correlations between the uPA levels and hormone sensitivity of tumor to estrogenes and progesterone not revealed. Concentration of uPA in cytosol fraction of tumor tissue in breast cancer T1N0M0 stage did not revealed their essential role for prognosis of disease, however in patients with T2N0M0 stage the levels of uPA in tumor tissue were almost in three times higher. The mathematical analysis of the data obtained allowed to reveal the threshold uPA level in breast cancer tissue, amount to the concentration of uPA >= 1 mg/ mg protein; in similar cases the most frequently the relapse of disease was observed.