STATE OF OXIDATIVE AND ENERGY METABOLISM OF THE BLOOD IN THERMAL INJURY UNDER THE INFLUENCE OF AIR-PLASMA FLOW CONTAINING NO
The work was devoted to the study of the activity of oxidoreductases in experimental combined thermal trauma after exposure to cold plasma containing NO. The study was conducted on 30 Wistar rats weighing 200-250 g, which were divided into 3 groups: 1-intact animals, 2 - control, 3 - experimental. Animals of the control and experimental groups were modeled combined thermal trauma (CTT) by the application of the contact burn and thermoinsulation injury. Animals were taken out of the experiment on day 14. Rats of the experimental group were daily irradiated with air plasma flow after the operation using the PLASON device at a distance of 1 cm from the burn surface for 2 minutes. The concentration of NO molecules in the plasma flow was ~3000ppm. The activity of aldehyde dehydrogenase, lactate dehydrogenase, superoxide dismutase, catalase was evaluated in erythrocytes. The specific activity of lactate dehydrogenase in direct and reverse reactions, as well as aldehyde dehydrogenase was increased after exogenous NO-therapy for burn wound in rats with combined thermal injury. The activation of antioxidant enzymes after the use of PLAZON in the treatment of combined thermal injury was noted.