The association of prostatic intraepithelial neoplasia of high degree in the peritumoral zone with recurrence after radical prostatectomy in patients with localized prostate cancer
The results of the evaluation of the prognostic significance of the presence of high-grade prostatic intraepithelial neoplasia (PIN2) in the environment of adenocarcinoma on the recurrence of localized prostate cancer (РС) after radical prostatectomy (RPE) in the next two years after the operation are presented. The results of examination of 176 patients with localized prostate cancer clinical stage T1c-T2cN0M0, which were performed by RPE, were studied. With the presence of PIN2 in the peritumoral zone in operating biopsies in patients with prostate cancer, the frequency of biochemical recurrence (26%) and histologically verified relapse (24%) is higher than in patients with PC without signs of neoplasia in the prostate (12,5% and 7,5%, respectively). The prognostic significance of the presence of PIN2 in the peritumoral zone in operating biopsies in patients with localized prostate cancer in relation to the risk assessment of recurrence in the next two years after surgery increases in combination with a shortened interval of biochemical recurrence (12 months or less): relative risk of relapse 13,0 (р = 0,05), diagnostic sensitivity 95,2%, diagnostic specificity 100%.