The Spectrum Of Gastrointestinal Motor Dysfunction In Patients With Early Stages Of Parkinson’s Disease And Efficiency Of Their Dietary Correction
Aim: To investigate the prevalence of gastrointestinal manifestations at the early stages of Parkinson’s disease (PD), and to evaluate the effect of their dietary correction. Materials and methods: One hundred forty three patients with initial manifestations of PD stages 1-2 (according to the Hoehn and Yahr scale) were examined. The group of patients with initial manifestations of the disease received the dietary correction along with the dopaminergic therapy (dopaminergic agonists) for the identification of the possibility of the dietary correction Results: Gastrointestinal symptoms in patients with initial manifestations of PD occurred were identified in 85,1% cases of PD stage I and in 82,5% cases of PD stage II (according to the Hoehn and Yahr scale). The most frequent of them were constipation and feeling of incomplete emptying, which were present 16.4±3.9 years before the onset of motor symptoms of PD. Unlike the control group, the group of patients that received dopaminergic therapy (dopaminergic agonists) and dietary correction revealed the decrease of severity of gastrointestinal dysfunction, such as constipation and anorectal dysfunction. The effect remained during the observation period (24 months). Conclusions: administration of the pharmacotherapy (ropinirole) combined with dietary correction decreased the severity of gastrointestinal dysfunction in patients with initial manifestations of PD