EVOLUTION OF PRIMARY MULTIPLE CRITERIA AND CLASSIFICATION OF PRIMARY MULTIPLE MALIGNANT TUMORS
The article provides an overview of one of the least studied problems of modern oncology - primary multiple malignancies. Facts from numerous studies show that over the last decade throughout the world, and an increase in the number of patients with multiple primary malignancies. Currently, the multiple primary malignant tumors are fairly common type of cancer. It should be noted that the increased incidence of multiple primary tumors in patients after radiotherapy and chemotherapy first tumor has become the main problem of the last two decades throughout the world. The current literature multiple primary malignant tumors or polyneoplasia called evolution of a two or more independent tumors. With the accumulation of material on the primary tumor multiplicity enough there was a question about the criteria of the primary tumor, to distinguish them from secondary tumors arising from metastatic origin. In this regard, the criteria of the primary tumor is of fundamental importance in the theory and practice of primary multiple tumor growth. This review summarizes the changes on the criteria multiplicity of malignant tumors and changes proposed classifications that occurred with the development of cancer and accumulation of material on the primary tumor multiplicity.