Cytokine Profile of Follicular Fluid in Women With History of Long-Term Infertility
The authors evaluated the levels of cytokines in follicular fluid (FF) in women with a history of long-term infertility and analyzed the results with regard to etiological factors. They concluded that low individual levels of IL-2, IL-4, and IL-7 and high levels of IL-8 in FF are prognostic markers of a failure of assisted reproductive technology treatment. According to the authors, imbalanced cytokine profile of FF is one of the mechanisms in the pathology of long-term infertility, regardless of its cause.