Effect of molixan on microbiocenosis of oral cavity after combined chemoradiation damage
Experimental studies have shown that the combined effect on animals of cytostatic (cisplatin) and cranio-caudal gamma-irradiation causes a significant increase in microbial contamination of the oral mucosa. At the height of chemoradiation oral mucositis (on the 15th day after irradiation), the number of colonies of nonhemolytic streptococci, staphylococci, enterobacteria increased by 3 times, Candida albicans and Candida glabrata - by 5 times in comparison with the group of intact animals. Course of injections of molixan at a dose of 30 mg/kg (during 15 days after chemoradiation damage) promoted normalization of microbiocenosis and reduced severity of oral mucositis. In animals treated molixan, the quantity of staphylococcus colonies decreased by 3 times, anaerobic bacteria - by 1.7 times, enterobacteria - by 1.6 times, non-hemolytic streptococcus - by 2.2 times, Candidas - by 3 times. When own antimicrobic activity of molixan was assessed, it was established that the preparation had direct bactericidal effect only in concentration from 400 mcg/ml and above.