EVALUATION OF THE EFFECT OF METHOTREXATE ON SERUM ENDOTHELIN LEVELIN PATIENTS WITH RHEUMATOID ARTHRITIS IN COMBINATION WITH CORONARY HEART DISEASE
The article presents the study results of content of endothelin-1 levels in patients with rheumatoid arthritis with various manifestations of coronary heart disease. Elevated endothelin-1 indicator in patients with rheumatoid arthritis and rheumatoid arthritis in combination with coronary heart disease compared with the controls is established. A significant decrease in serum levels of endothelin-1 during the treatment of rheumatoid arthritis with methotrexate is revealed, that indicates vasoprotective properties of the drug.