REACTIVITY OF PIAL ARTERIES IN HYPERTENSION: THE IMPACT OF MESENCHEMICAL STEM CELLS
The reactivity of arteries of the sensorimotor cortex in the normotensive Wistar-Kyoto rats (WKY) and in the spontaneously hypertensive rats (SHR) the age of 4 and 12 months was studied by the method of intravital microscopy during an application of the norepinephrine and acetylcholine to the surface of the brain. It was shown that pial arteries of 4-months-old SHR had an increased constrictor reaction and a reduced dilator reaction. The reactivity of pial arteries of 12-month SHR was not statistically significantly different from that of 12-months-old WKY. The reactivity of the pial arteries under the same conditions was studied in SHR rats three weeks after an intracerebral transplantation of human mesenchymal stem cells (MSCH). It was shown that the transplantation of MSCH to 3-months-old SHR almost completely restored the constrictor and dilator capacity of the pial arteries to the level of young normotensive animals. Transplantation of MSCH to 12-months-old SHR was not effective: the constrictor reaction of microvessels increased and the dilator reaction did not change.