Nitric Oxide in Vascular Endothelium: Control of Production and Mechanisms of Action
The review analyzes the literature on the regulatory role of NO in blood vessels. Particular attention is paid to the modern ideas about the regulation of expression and activity of endothelial NO-synthase, including those invooving micro RNAs – a new class of small regulatory molecules. The physiological mechanisms activating NO-synthase in endothelial cells and key targets of NO-pathway in vascular smoth muscle cells are reviewed as well.