Persistence of zopiclone in liver tissue
The authors investigated whether the hypnotic drug zopiclone persisted in cadaveric liver tissue when its samples were stored in different conditions. During the investigation, they employed a procedure involving a method for the extraction of substances from the biological material with acetone; primary purification through liquid extraction; additional purification and pre-identification via a TLC screening; and qualitative and quantitative UV-spectrophotometric analysis. Zopiclone as a rather stable on contact with cadaveric liver tissue persist at 5°С and 18-20°С for 3 months and may be isolated, identified, and quantified.