Influence of Imupret on the level of nicotinamideadeninedinucleotide in experimental type 1 diabetes
There was revealed the reduction of body weight by 19% and the increase of concentration of blood glucose by 2.3 times on the experimental model of type 1 diabetes in rats. Significant violations of the energy processes can be caused by hyperglycemia, which is evidenced by the reduction of nicotinamideadeninedinucleotide (NAD) by 24% in the blood of the studied animals. The reduction of dinucleotide, in its turn, leads to change of the ratio of free NAD(P)/NAD(P)H pairs in the direction of reducing reactions, which inhibits glycolysis and functioning of citric acid cycle. The use of Imupret partially restored the energy processes (probably, in all tissues of rats with experimental diabetes), which is reflected through the content of dinucleotide in the blood. So, Imupret can be used in type 1 diabetes as energy-saving drug.