ANTITUMOR EFFECTIVENESS OF RADIOTHERAPY FOR ORAL MUCOSA CANCER (OMC) COMBINED WITH LOCAL SONODYNAMIC CHEMOTHERAPY
Sonodynamic chemotherapy was used to improve the results of radiotherapy for initially unresectable cancer of the oral mucosa Т2-4N0-2M0. 31 patients of the main group ery other day received dry platidiam 5 mg using mid-range ultrasound (0.88 MHz, I = 0.4-1.0 W/cm2, exposure for 5-10 min.) in the middle of the interval between fractions of a single dose of 1.2 + 1.2 Gy external radiation to the primary site of the tumor. Morphological regression of the primary tumor after 40 isoGy was 87.1 % vs. 46.7 % (p < 0.05) in the control group (n = 30) receiving radiotherapy only. After this stage of treatment, the number of patients with resectable tumors in the main group was 1.9 times higher than in the control (45.2 vs. 23.3 %) (p < 0.05).