Pathogenic approach to treating patients with primary dysmenorrhea
Objective. To carry out a systematic analysis of the data of modern literature on the etiology and pathogenesis of dysmenorrhea, by substantiating and optimizing the treatment of patients with primary dysmenorrhea. Material and methods. The review included the data of foreign and Russian articles published over the past 10 years and found in Pubmed on this topic. Results. Thus, dysmenorrhea is a rather common disease that reduces quality of life, the main cause of which is overproduction of prostaglandins, hormonal imbalance (abnormal estradiol/progesterone ratio), stressful states, and depression (reduced gamma aminobutyric acid levels). Conclusion. Nonsteroidal anti-inflammatory drugs and combined oral contraceptives proved to be effective and pathogenetically sound drugs used for the therapy of primary dysmenorrhea.