Roentgenendovascular technique for the treatment of locally advanced breast cancer
For preoperative treatment of locally advanced breast cancer roentgenendovascular technique of superselective targetintra-arterial chemotherapy has been developed. Blood supply of locally advanced breast cancer occurred fromsome sources belonging to the system of the subclavian and axillary arteries. Catheterization of target tumor vessels was performed from the pool of internal thoracic, lateral thoracic, subscapular arteries depending on the affected side. Target intra-arterial chemotherapy has been performed in 70 patients. The age of patients was between 38 and 63. The diagnosis was verifi ed by biopsyin all patients. For intra-arterial chemotherapy cisplatin at a dose of 100mg/m <sup>2</sup>, cyclophosphamide at a dose of 900 mg/m <sup>2</sup> wereused. Doxorubicin was administered intravenously at a dose of 90 mg/m <sup>2</sup>. Chemotherapy included 3-5 courses at an interval of 3 weeks. Clinical observation showed reduction of the primary tumor of diff erent extent, softening of its structure, pain relief or its disappearance, reduction in tumor fixation to the tissues of the anterior chest wall, shrinkage of the axillary lymph nodes. Complete tumor regression occurred in 13.8%, partial - in 44.4% of patients. Complications and side eff ects of intra-arterial chemotherapy such as nausea, vomiting, loss of appetite occurred 2-3 days after the treatment in 24 patients and were relieved due to symptomatic therapy.