FEATURES OF EXPRESSION OF OCT4, NANOG AND ENDOGLIN IN RENAL CELL CARCINOMAS
Possibilities of the potential stem markers as cancer stem cells in renal cell carcnomas (RCC) and their prognostic significance are currently being studied. In this regard, the study of the expression pattern of transcription factors - NANOG and OCT4, as well as endoglin in the RCC is of great interest. The aim of the study was to conduct a comparative assessment of the expression of stem markers NANOG, OCT4, and CD105 in histological variants of renal cell carcinoma and determine their prognostic significance. Material and methods. The study was performed on surgical material from 225 patients with renal cell carcinoma. Antibodies used: NANOG, OCT4 and CD105. The nonparametric Pearson agreement test (χ2) was used to identify the differences between the compared groups. Results. NANOG expression was detected in 150 (66.7%) cases. Nuclear expression of OCT4 was detected in 72 (32%) samples in only single tumor cells. A positive response to CD105 was determined in 60 cases (26.7%). Conclusion. Reliable associations between the expression of CD105 and clinical parameters were revealed depending on the histological variant of renal cell carcinoma.