MODERN OVERVIEW ON OBJECTIVE DIAGNOSIS OF BBB RESISTENCY IN REHABILITATION OF CHILDREN WITH PERINATAL HYPOXIC-ISCHEMIC LESION OF THE CNS
Hypoxic-ischemic lesions of the CNS in the perinatal period can result in hydrocephalus, microcephaly, infantile cerebral paralysis (ICP), epilepsy, and psychomotor retardation. It is not always possible to accurately evaluate the disease severity and make a prognosis using routine methods of clinical, instrumental, and laboratory examination. The content of different biomarkers in the serum is one of the most informative biochemical indicators of the state of the blood-brain barrier (BBB). Glial fibrillary acidic protein (GFAP), neuronspecific enolase (NSE), and proteins of the S100 family do not cross the BBB and practically cannot be detected in serum under normal conditions. When BBB permeability is compromised, NSPs penetrate into the peripheral blood and may be measured there. Vascular endothelial growth factor (VEGF) may be important for diagnostics for the evaluation of the state of endothelial cells. Dynamic assessment of NSPs in serum may be used to evaluate BBB resistance, to estimate the severity of a CNS lesion, and to determine the prognosis for children with a perinatal hypoxic-ischemic lesion of the CNS.