THE FORMATION OF NEPHROSCLEROSIS IN CHILDREN. CORRELATION STUDIES MORPHOMETRIC CHANGES
Study whose purpose was to develop the morphological criteria nephrosclerosis for early diagnosis of the renal damage degree in children was presented. The material of the study is based on 29 samples of kidney tissue of children suffering from obstructive uropathy. The morphometric changes in the tissue structure of a kidney area, which defined the degree and severity of the renal parenchyma was determined. The statistical analysis revealed correlations of varying strength and direction of morphometric criteria nephrosclerosis with the degree of development of degenerative changes in the glomeruli, tubules, vessels with an outcome in multiple sclerosis. Comparing the data of the statistical correlation studies and morphometric changes 3 consecutive stages of development of renal scarring was allocated. The presence of renal tissue dysplasia is one of the major risk factors for renal disease. Proposed classification can be used to indicate the severity of kidney damage, which will mainly affect the methods antisclerotic and renoprotective therapy.