NONSPECIFIC RESISTANCE LEVEL IN ACUTE DYSENTERY OF VARYING SEVERITY
Decisive role in the course and outcomes of bacterial dysentery is the state of natural factors of protection. 204 patients with acute dysentery of varying severity were examined to identify indicators of nonspecific resistance in terms of the content of blood lysozyme, serum bacterial activity, phagocytic activity of leucocytes and recovery test for nitro blue tetrazolium.It is established that the functional activity of lymphocytes and bactericidal activity of blood serum dramatically increase in the acute phase, and then decline, which, apparently, correlates with the level of microbial load. The observed shifts in the parameters of nonspecific resistance can be regarded as the mobilization of adaptation reserve of the organism in patients with acute dysentery. However, in severe cases there is a decrease in nonspecific resistance in the phagocytic activity of leukocytes and phagocytic number and viability of enzyme systems of phagocytes, which creates conditions for a protracted and recurrent infection process.