Study of anthelmintic activity of <i>Tanacetum vulgare</i> in experiments with <i>Caenorhabditis elegans</i>
In experiments with soil nematode Caenorhabditis elegans it was shown that aqueous extract of Tansy flowers possesses anthelmintic activity. In concentrations range 0.3-10 % T. vulgare extract caused disturbances in motor program of nematodes’ swimming. Similarity in toxic action Tansy extract and anthelmintic drug levamisole on C. elegans organism made it possible to suppose that nematodes’ nervous system is a target for toxic action of Tansy extract. Dynamic of toxic action of Tansy flowers on C. elegans organism made it possible to suppose the possibility of quick adaptation of nematodes to substances contained in T. vulgare extract. Using of C. elegans to study nematocidal activity of T. vulgare can allow to identify components of Tansy extract effective as anthelmintic drugs and detect the mechanism of anthelmintic action of Tansy extract.