PECULIARITIES OF OXIDATIVE STRESS IN CHRONIC HEPATITIS C
Aim. To study the blood serum lipid peroxidation processes and antioxidant enzymes activity in patients with chronic hepatitis C (CHC) and to assess the correlation between these parameters and impairment of functional hepatic tests. Materials and methods. Malonic dialdehyde concentration (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR) activity as well as alanine and asparagine transaminases (ALT and AST), cholestasis tests were determined in 46 patients with CHC. The control group included 26 persons comparable by their sex and age. Results. Increase in MDA concentration to 6,26±3,2 ( p <0,001) compared with the control was observed in CHC patients. Raised activity of enzymes was detected: SOD compared to the control group heightened to 40,39±12,78 ( p <0,001), but GR - to 31,66±9,64 mcmol/l/min ( p <0,001); CAT activity was significantly reduced: 9,93±4,91 mcat/l ( p <0,001). Direct reliable correlation between MDA level and transaminases, between GR and AST were found. Reverse reliable correlation between MDA and CAT ( r =-0,319, p =0,048) were observed. Decrease in CAT correlated with increase in cytolysis indices - ALT and AST. Conclusion. Among CHC patients, blood serum lipid peroxidation activation correlates with the degree of manifestation of hepatocyte cytolysis syndrome. At the same time, oxidative stress is not accompanied by an adequate growth of activity of antioxidant enzymes.