CLINICAL DIAGNOSTIC SIGNIFICANCE OF FAS/APO-1(CD-95)-ANTIGEN IN HIV- INFECTION
As a result of the examination of 83 HIV-positive patients it has been established, that HIV-infection reveals higher levels and higher optical density of sFas/Apo-1(CD-95)-antigen in blood serum in comparison with those in practically healthy donors. The patients in AIDS stage detect higher average levels of optical density of sFas/Apo-1 (CD-95)-antigen in the blood serum, than the patients out of the AIDS stage. The average optical density levels and frequency of revealing the increased optical density levels of sFas/Apo-1(CD-95)-antigen in the blood serum are significantly higher in the HIV-positive patients with number of CD4+T-lymphocytes less than 200 in 1 mkl in the blood, than in the patients with that more than 200 in 1 mkl. The increased optical density levels оf sFas/Apo-1(CD-95)-antigen are defined in the HIV-positive patients only in the development of moderate and expressed immune suppression (CD4 < 350 cells/mkl) and directly moderately correlate with a clinical stage of HIV infection.