Fixed perindopril/amlodipine combination in treatment of diabetes mellitus type 2 patients
Prevalence of arterial hypertension (AH) in diabetes mellitus type 2 patients (DM2) exceeds that in general population. AH patients have a higher risk in developing DM2. Patients with AH and DM2 have higher cardiovascular morbidity and mortality rates. Heart, brain and other target organs are more frequently affected in these patients. Appropriate blood pressure (BP) control (its target level) is of great importance for these patients. The article presents a rational scheme of BP reducing medications in DM2 patients based on the results of the clinical studies and the everyday clinical practice. The article also demonstrates the importance of a combined therapy that includes medications blocking the activity of the renin-angiotensin system, and calcium antagonists, where the fixed combination of perindopril/ amlodipine is the most promising.