VASCULAR TARGETS OF CANCER TUMORS FOR RADIOTHERAPY
One of the most important promoters of angiogenesis is considered to be the vascular endothelial growth factor (VEGF) which stimulates formation, growth and permeability of blood vessels. Radiation-induced VEGF activation subsequently attenuates vasculature damage of blood vessels and leads to reduced tumor cytotoxicity. It has been shown that combination of antiangiogenic agents with radiation treatment has the potential to enhance tumor cytotoxicity. This article also focuses on potential targets for radiation therapy, which are VEGF inhibitors, as well as eicosanoid, sphingolipid and ceramide pathways.