The effect of immunotherapy with recombinant IL-1β on clinical and immunological parameters of patients with complicated fracture of the mandible
Importance The treatment of the mandible fracture complications remains an actual problem of modern maxillofacial surgery. The article discusses the possibility of using immunomodulator «Betaleukin» to prevent transformation of the complicated course of fractures within the dentition in traumatic osteomyelitis. Objectives The aim of study was to determine the effectiveness of the use of recombinant interleukin 1- p for patients with complicated mandible fractures. Methods 104 patients were separated into 3 groups: the control group and 2 main groups. In the 1st main group locally applied hydrogel «Koleteks-Beta». In the 2nd main group, the drug «Betaleukin» was administered parenterally. The efficacy of immunotherapy was evaluated by clinical criteria (pain in region of fracture, normalization of body temperature, soft tissue swelling, hyperemia of the mucosa, and formation of a fistula) and immunological criteria (the functional activity of neutrophils saliva). Results Patients who were treated with Betaleukin, in earlier periods, countered by the soft tissue swelling. Total clinical score in patients of the comparison group depended on the method of fixation of bone fragments, and in the group of operated patients it was statistically higher than in orthopedic. In both mine groups, the figure was evidence of better healing of the bone wound. Patients of both this groups revealed increase of the functional reserve of neutrophils. Conclusions The study revealed the clinical and immunological efficiency of application Betaleukin for patients with complicated fractures of the mandible. Recombinant IL-1β helps prevent the development of traumatic osteomyelitis.