FORMATION OF ANTITUMOR RESISTANCE OF THE BODY THROUGH THE PARTICIPATION OF SOME IMMUNOHEMATOLOGICAL REACTIONS
The formation of an immune response in the development of any pathological process, including malignant growth, is known to be a very complex act, affecting not only elements of the system of immunocompetent organs, but also a number of heterogeneous structures in relation to them. In this study, the phenomenon of equinocytosis, which was shown in previous studies, to develop tumors in the experiment and clinic, was studied from these positions. Regardless of the model used (spontaneous, chemically induced, pervathal tumors) and the localization of cancer in humans (milk gland, stomach, melanoma), in the blood of the malignant body naturally observed some degree of increase in the number of red blood cells with a characteristically altered surface - equinocytes. The research was carried out in an experiment and clinic. These results show that the resistance of animals of the C57BL/6 line is characterized by low equinocytes, increased number of white blood cells, mainly due to lymphocytes and zoozinophyls. In addition, lymphocytes resistant to the growth of animals were characterized by reduced activity of one of the lysosomal enzymes - acidic phosphatease. In the protein spectrum of the serum of mice, the C57BL/6 line was observed to have a higher content of "ɑ2-macroglobulin and a decrease in the area of posttransferrins compared to carcinogenic animals (P<0.001, P<0.05 respectively). Thus, the materials presented in this paper allow talking about the participation of red blood cells in immunological reactions, the organism forming in response to the development of tumors. In addition, they indicate a certain relationship between changes in the surface membrane of red blood cells - ehinocytosis and autoimmune processes developing in the tumor-affected body.