Association of adiponectin gene alleles with type 2 diabetes mellitus in residents of Bashkortostan
Type 2 diabetes mellitus (T2DM) is one of the most acute problems of the modern world. The disease is characterized by high ratio of micro- and macrovascular complications. T2DM is a multifactorial and polygenic disease, structure of hereditary predisposition to which may be population-specific. Aim - the analysis of allelic associations of adiponectin gene (<i>ADIPOQ, rs17366743</i>) with T2DM, its clinical and metabolic characteristics and complications in T2DM patients resident in the Republic of Bashkortostan. Material and methods. 3 PCR-based method of genotyping with polymorphic marker <i>rs17366743</i> of <i>ADIPOQ</i> gene in 433 T2DM patients and 428 healthy controls, residents of Bashkortostan. Results. The ratio of genotype CT and allele С was higher in T2DM patients compared with controls (15.7% vs. 6.8%; <i>p</i>=0.0002 and 7.8% vs. 3.4%; <i>p</i><0.0001, respectively). Genotype ТТ and allele Т were less frequent in T2DM than in healthy subjects (84.3 and 93,2%; <i>p</i>=0.0002; 92.2 and 96.6%, <i>p</i><0.0001, respectively). The association with the development of diabetic retinopathy and cataract was shown (<i>p</i>=0,044, <i>p</i>=0,008, respectively). Conclusions. Allele C and genotype CT are risk markers of T2DM (OR=2.43 and 2.56 respectively).