SPECIAL FEATURES OF THE PATHOGENESIS OF AUTOIMMUNE THYROID DISEASE
Autoimmune thyroid disease occupies a leading place in the structure of thyroid pathology. These include diseases like hyperthyroidism accompanied – diffuse toxic goiter and hypothyroidism – an autoimmune Hashimoto's thyroiditis. There is a close relationship between the immune and endocrine systems are due to many features of the pathogenesis of autoimmune thyroid disease. A significant contribution to the development of autoimmune process in autoimmune thyroid disease brings the presence of mutations in the following genes - ctla4, stat4, cd247, bcl2l / l15, magI3, phtf1, ptpn22 and gpr103. Autoimmune thyropathology this disease with genetic predisposition, which are based on immune inflammation of the thyroid gland, thyroid status changes manifested as towards hype- and hypothyroidism, and the clinical manifestations of these diseases are not limited to disorders of the thyroid status, a large contribution to the pathogenesis data contribute diseases secondary immunological and endocrine disorders as a reflection of an existing autoimmune process.