Assessment of the effect of the concentration of manganese in the material OK-015 implanted in the tibia on the change in the ultrastructure of the biomineral materials of the lower jaw and lower incisor
In an experiment on 210 sexually mature white rats, it was established that implantation in the proximal diaphysis of the tibia of OK-015 material saturated with manganese at a concentration of 0.10% had a negligible effect on the change in the ultrastructure of the bone biomineral of the lower jaw branch, from 7 to 90 days and during the period from 15 to 60 days to change the ultrastructure of the dentin biomineral of the lower incisor. The maximum influence was recorded by 30 days on the change in the crystallite size of the bone biomineral (П<sup>2</sup> - 0.559) and by 15 days on the change in the size of the unit cells of the dentin biomineral along the a axis (П<sup>2</sup> - 0.466). An increase in the concentration of manganese in the implant to 0.25% had a significant effect during the entire observation interval on the change in the ultrastructure of the bone biomineral of the lower jaw branch, and in the period from 7 to 90 days on the change in the ultrastructure of the dentin biomineral of the lower incisor. The maximum influence was recorded by 7 days on the change in the size of the unit cells of the bone biomineral along the axes a and c - (П<sup>2</sup> - 0.597 and 0.608), by 15 days on the change in the size of the unit cells of the bone biomineral along the axes a and c (П<sup>2</sup> - 0.568 and 0.548 ), by 60 days to change the size of the dentin crystallites (П<sup>2</sup> - 0.551) and by 60 and 90 days to change the crystallite sizes of the bone mineral (П<sup>2</sup> - 0.617 and 0.605). A further increase in the concentration of manganese in the implant up to 0.50% had a significant effect during the entire observation interval on the change in the ultrastructure of the bone biomineral of the lower jaw branch and the dentin biomineral of the lower incisor. In the early stages after implantation, the maximum influence power was recorded by 7 days on the change in the size of the unit cells of the bone biomineral along the axis a (П<sup>2</sup> - 0.620), and by 15 days on the change in the size of the unit cells of the bone biomineral on the axis a (П<sup>2</sup> - 0.642). In the later stages after implantation, the maximum influence power was recorded by 90 days on the change in the coefficient of microtexturing of bone and dentin biominerals (П<sup>2</sup> - 0.482 and 0.581).