Physiological characteristics of puberty for adolescent girls suffering from acne
The physiological characteristics of sexual development and immune status in girls suffering from acne disease have been analyzed. It is revealed that at puberty, in girls suffering from acne, the concentration of luteinizing and follicle-stimulating hormone in peripheral blood was significantly lower than girls in the control group. While menarche was in girls 14-13 years old with acne there indexes were significantly less than in the control group. The formation of breast and pubic hair at puberty, they lagged behind in comparison with girls in the control group. The immune status of acne was characterized by a decrease in cytotoxic lymphocytes and increased T-lymphocytes helper cells and immunoregulatory index. In the peripheral blood of these girls there was an increase in interleukin-4 and serum tumor necrosis factor, level of circulating immune complexes, mainly due to the low concentration of serum interferon γ was significantly lower than in healthy girls. The indicators of basal metabolism indicate that girls with acne disease higher rates of creatinine and glucose, and also lower neeterificirovannah fatty acids and enzyme activities of alanine (Alat) and aspartic (AST) transferases than girls in the control group. Thus, ladies suffering from acne, was characterized by delayed and at the same time disharmonious puberty. They are characterized by a later menarche, delayed the establishment of the rhythm of the menstrual cycle, some changes of rhythm humoral regulation and biochemical homeostasis. (For citation: Pilnik EN, Pyatibrat AO, Pyatibrat ED. Physiological characteristics of puberty for adolescent girls suffering from acne. Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(4):69-74. doi: 10.17816/RCF15469-74).