MODELING THE FORMATION OF AMYLOID FIBRILLS
We propose a general kinetic model to describe the process of amyloid fibrill formation, which includes the nucleation polymerization mechanism with sequential addition of monomers to oligomers and autocatalytic growth of amyloid aggregates, which implies the exponential growth of all types: branching, fragmentation, and growth from the surface. Computer simulations showed that the model correctly describes the experimentally observed growth stages of amyloid fibrills. In addition it was shown that the presence of the exponential growth stage in the model is crucial for modeling of the formation of amyloid fibrills. A key feature of the model is the presence of the stage of exponential growth of amyloid aggregates, which can describe several scenarios: branching, fragmentation and growth from the surface. Based on the data obtained with our model, conclusions were made about the significance of each of the stages in the assembly of amyloid fibrills