Influence of female sex hormones and cytokines on adhesive interaction of mucosa epithelial cells with Candida albicans in vitro
It was detected woman sex hormones influence on the ability of mucosal epithelial cells to absorb C. albicans in vitro. Thus progesterone and luteinizing hormone stimulate, but estradiol suppresses contact of mucosal cells with candida. Hormone-treated buccal and vaginal epithelial cells have shown similar reactivity for C.albicans. Inflammatory cytokines IL-1, IL-6, IL-8 and TNF augment contacts between buccal cells and C.albicans, on the contrary, INFα reduces candida possibility to epithelial cell colonization.