Changes in the level of acetylcholine in chemical epidural neurolysis in patients with colorectal cancer
The study analyzed the intensity of pain in patients with colorectal cancer depends on the biochemical response against pain. It is known that pain accompanied by formation of mediators of pain, including acetylcholine is one of the major. Objective of the study was to examine the intensity of pain in patients with colorectal cancer according to the dynamics of acetylcholine and its treatment by chemical epidural neurolysis. In the study of the dynamics of acetylcholine in the pre- and postoperative period, we analyzed the dependence of the intensity of pain from the quantitative characteristics of a me- diator. Was compared to standard postoperative opioid analgesia in group I patients and epidural analgesia with epidur- al chemical neurolysis patients in Group II of the study. For example, using our method of epidural chemical neurolysis as an effective treatment of pain in oncologic patients, it was possible to study the physiological response of the body to pain.