ON INTERRELATIONSHIP BETWEEN PROGRESSING INCREASE OF PROINFLAMMATORY BLOOD CYTOKINES AT DIFFERENT STAGES OF NEOPLASIA DISTRIBUTION IN PATIENTS WITH COLON ASCENDENS ADENOCARCINOMA
45 patients suffering from colon ascendens adenocarcinoma were examined at different stages of neoplastic process distribution. The patients stayed in the Oncology and Departmental Surgery Clinic of the Saratov GMU (State Medical University) n.a. V.I. Razumovsky at the Russian Minzdravsotsrazvitiya (Ministry of Healthcare and Social Development) GOU VPO (State Educational Institution of Higher Professional Education) (housed by the Railway Clinical Hospital at the Saratov II Station NUZ (Non-Governmental Healthcare Institution) and the Regional Clinical Hospital in the city of Saratov State Healthcare Institution) during the period from 2009 to 2013. The purpose of the research was to study the blood cytokine profile at earlier stages of neoplasia (T1-2N0M0) and later (T3-4(а,в) N0M0, T3-4(а,в) N1-2M0). Proinflammatory cytokines (IL-1, IL-6, TNF α, GCSF) content in the patients’ blood upon the admission to the hospital, before treatment, was studied. Early in the colon ascendens adenocarcinoma, increase of IL-1, TNF α, GCSF level was observed in the blood. With the neoplasmic process distribution (T3-4(а,в) N0M0, T3-4(а,в) N1-2M0), IL-1, TNF α, GCSF level was increasing in blood, as well as IL-6 level, for the first time.