Cellular immunity in patients with chronic viral hepatitis C
The analysis of changes of cellular immunity in patients with chronic viral hepatitis C is studied. 69 people at the age from 16 to 58 years were examined. The study demonstrated that all patients with chronic viral hepatitis C had changed immunological indicators, compared to the norm: a pronounced growth in the population of activated T-lymphocytes (CD3+HLA-DR+) with a significant reduction in populations of activated T-helper lymphocytes (CD3+CD4+HLA-DR+), activated T cells (CD3+CD8+HLA-DR+), NK-cells (CD3-CD16+CD56+) and T-NK-cells (CD3+, CD16+CD56+) manifesting deregulation of cellular immunity. Adhesion of lymphocytes with platelets decreased in 73, 8 % of cases. This indicates the dysfunction of T-lymphocytes, which is manifested in the decrease of platelet adhesion.