The Role of Blood Kallikrein-Kinin System in Patients with Cerebral Ischemia
Kallikrein-kinin system of the body plays an important role in the regulation of hemodynamics, vasodilation, control of the systemic blood pressure, etc. In the present work, we studied changes in parameters of kallikrein-kinin system in patients with cerebral ischemia. Fifty patients were examined: 30 - with ischemic stroke, including 10 with pathology of the cardiovascular system, and 20 - with chronic ischemic brain disease. A statistically significant increase in the level of kallikrein in patients with ischemic stroke (23.50 ± 1.24 nmol/l) was found, especially in patients with concomitant cardiovascular disease (32.74 ± 1.20 nmol/l), compared to patients with chronic ischemic brain disease (14.38 ± 0.32 nmol/l) and controls (13.75 ± 0.23 nmol/l). It was noted that the kallikrein-kinin system parameters in patients with ischemic stroke were normalized by days 10-15 days of therapy, while they remained at the baseline level in patients with concomitant heart disease.