THE INFLEUNCE OF THE TREATMENT ON THE CYTOKINES LEVELS IN SYNOVIAL FLUID IN RHEUMATOID ATHRITIS PATIENTS
In this article are performed the results of investigation of proinflammantery cytokines concentration (IL-1β, IL-6, TNF-α), osteoprotogerine (OPG), receptor of activating of nuclear factor kappa ligand (RANKL) in the synovial fluid of 74 patients with rheumatoid arthritis. The analyses performed the differences between the levels of investigated cytokines in the patients with different duration of rheumatoid arthritis (RA). The corrigative infleunce of infliximab was more effective in comparison with metotrexate, on the cytokine status of synovial fluid in RA patients. The best results were achieved in the patients with early RA.