Synthesis, Structure and Biological Activity of Mixed-Ligand Amine-Containing Copper(II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-<i>N</i>-(prop-2-en-1-yl)- hydrazinecarbothioamide
Сopper(II) nitrate reacts in ethanol with 2-(2-hydroxybenzylidene)- N -(prop-2-en-1-yl)hydrazinecarbothioamide H<sub>2</sub>L in a 1:1 molar ratio to form coordination compound Cu(HL)NO<sub>3</sub>·H<sub>2</sub>O. Ligand H<sub>2</sub>L reacts with copper(II) nitrate and amines [imidazole (Im), 3,5-dibromopyridine (3,5-Br<sub>2</sub>Py), 4-methylpyridine (4-Pic)] in a 1:1:2 molar ratio to give coordination compounds CuA(HL)NO<sub>3</sub>· n H<sub>2</sub>O [A = Im, 3,5-Br<sub>2</sub>Py, 4-Pic; n = 0, 3]. The structures of the obtained amine-containing complexes were determined by X-ray diffraction analysis. The synthesized complexes exhibit antimicrobial, antifungal and antioxidant activities, as well as selective anticancer activity against human leukemia HL-60 cell line.