STUDY PHENOTYPIC PROPERTIES OF DENDRITIC CELLS FROM WHOLE BLOOD OF PATIENTS WITH BREAST CANCER
Components of tumor microenvironment may contribute to cell populations forming suppressing antitumor immunity. The aim of this work is to study dendritic cells as potential biomarkers reduce antitumor immunity in breast cancer. The object of investigation has been used from the peripheral blood of patients with breast cancer. Determination of circulating plasmacytoid and myeloid dendritic cells was performed by flow cytometry using conventional markers of dendritic cells: CD 123/CD 11c (for plasmacytoid and myeloid DCs, respectively) and differentiation markers (maturation) - CD83, CD86, CCR7. Thus, a comparison of the content and myeloid dendritic plazmotsitoidnyh cells in peripheral blood of breast cancer patients and identified phenotypic and functional characteristics of dendritic cells.