ANTI-ALLERGIC ACTIVITY OF VIOLA HERB TEA
Widespread occurrence of allergic diseases requires the search for new medicines to solve this problem including their search through natural sources. The aim is to study anti-allergic activity of Viola herb tea in comparison with Bidens medicinal plant raw material. It was found that Viola herb tea containing polysaccharides and phenolic compounds has a pronounced dose-dependent and anti-anaphylactoid effect in vivo comparable to Bidens herb tea; a semi-effective dose of Viola herb tea made 342 mg/kg. The level of mast cell degranulation in the group studied in the presence of Viola herb tea was in the range of 14,5-21,0% and at all doses was significantly lower (p < 0,05) than the level of mast cell degranulation in animals of the studied group in the presence of an allergen. The percentage of mast cell protection against degranulation in vitro of Viola herb tea is 31,2-65,7%. A semi-effective dose of Viola herb tea on the model of mast cell membranes stabilization is 433 ng/ml and is 1,6 times inferior to Bidens herb tea.