The Value of Diffusion-weighted Magnetic Resonance Imaging in the Preoperative Evaluation of the Grade of Brain Gliomas
Objective. To compare the values obtained for the measured diffusion coefficient (MDC) of brain gliomas with cell density and Ki-67 proliferative activity index and to study whether diffusion-weighted MRI (DW-MRI) can be used in the preoperative evaluation of the grade of glial tumors. Material and methods. Diffusion-weighted images of 39 patients with brain gliomas were studied. MDC, cell density, and Ki-67 proliferative activity index were calculated for each tumor. The correlation between MDC values, cell density, and Ki-67 proliferative activity index was analyzed. Results. Comparison of the mean values for MDC revealed a significant difference between grades I-II and III-IV tumors. There were statistically significant differences in the mean Ki-67 index between different grades of gliomas. Evaluation of the correlation between MCD and Ki-67 proliferative activity index demonstrated moderate and strong inverse correlations for low- and high-grade tumors, respectively. Conclusion. The procedure using DW-MRI along with MDC calculation can be used as an additional non-invasive method for the preoperative estimation of the grade and proliferative potential of brain gliomas.