INFLUENCE OF DALARGIN ON REPARATIVE ABILITY OF THE GASTROINTESTINAL MUCOSA IN VARIOUS GASTROENTEROLOGICAL DISEASES
The influence of Dalargin on reparative ability of the gastric mucosa in NSAID-gastropathy and of the ileum mucosa on Crohn's disease has been studied. A daily introduction of Dalargin in the dose of 0,002 g for four weeks signifi cantly reduced the progression rate of NSAID-gastropathy in 29 patients with osteoarthrosis. Dalargin activated DNA synthesis in epithelial cells of the stomach, facilitating the tissue homeostasis maintenance. In 15 patients with Crohn's disease included in the complex therapy a daily dose of Dalargin of 0,002 g for four weeks promoted more pronounced disease activity reduction according to endoscopic and morphological criteria, and normalization of enterocytes proliferative activity. The mechanisms of protective Dalargin actions implementation in NSAID-gastropathy and Crohn's disease is the subject of the discussion.