Modern Capabilities in Management of Resistant Trophoblastomas and Relapses
Objective of the Review: to focus on the result of management of patients with resistant malignant trophoblastomas (MTB) and their relapses; to emphasize the possibility of further search for optimal ways to achieve remission. Key Points. Modern early diagnostic tools, use of conventional first-line chemotherapy regimens, and adherence to the treatment algorithm allow minimising mortality in MTB patients. Despite highly efficient first-line chemotherapy regimens, some patients develop tumour resistance to chemotherapy. Management of such patients is one of the most difficult challenges in clinical gynecological oncology. MTB relapses are a problem as well. Patients with trophoblastoma relapses are the hardest to treat. Conclusion. Insufficiently successful management of patients with resistant trophoblastomas and relapses necessitates optimisation of early local diagnostics, with practical introduction of new efficient regimens of chemotherapy, immunotherapy, and radiosurgery.