ENZYMOLOGICAL FEATURES OF LYMPHOCYTES AND ERYTHROCYTES IN OSTEOARTHRITIS PATIENTS IN THE EARLY STAGE OF THE DISEASE
Тhe activities of adenosine deaminase (ADA), AMP-deaminase (AMPDA) adenindezaminase (AD) and 5'-nucleotidase (5'-NT) were determined in lysates of lymphocytes and erythrocytes of 57 osteoarthritis (OA) patients with the disease duration from 3 to 23 months. Poliosteoarthritis with synovitis is accompanied by the increased activity of 5'-NT and AD in lymphocytes, increased activity of all enzymes in erythrocytes. The increase of the joint damage stage is characterized by the decrease of ADA activity, increase of AMFDA, AD, 5'-NT activity in lymphocytes and increased activity of all enzymes in erythrocytes. It is shown that determination of ADA, AMFDA, AD, 5'-NT activities promotes the early identification of acute phase in OA.