EFFECT OF PREGNANCY-SPECIFIC β1-GLYCOPROTEIN ON CHEMOKINE PROFILE OF CULTURED T-HELPER AND MONONUCLEAR CELLS
The effect of human pregnancy-specific β1-glycoprotein (PSG) on the production of chemokines by intact mononuclear cells and monocultures of CD4+ cells in vitro by Bio-Plex® multiplex immunoassay technology was studied. It has been established that PSG suppresses the production of IL-8, MIP-1α, MIP-1β, RANTES and MCP-1, chemokines, an elevated level of which is associated with spontaneous abortion. As a result, it can be concluded that PSG forms the fetoprotective chemokine profile of the studied immune cells.