COMORBIDITY OF ALCOHOL DEPENDENCE AND DEPRESSIVE DISORDERS
In 25-30% of cases alcohol dependence (AD) is combined with depressive disorders (DD) which are observed at all stages of the disease and are marked by low differentiation, polymorphism and variability. Combination of AD and DD makes it more difficult to diagnose and to implement a therapy, worsens the prognosis with incident disability of patients, reduced quality of life and social stigmatization. The purpose of this review is to analyze etiopathogenetic aspects and clinical signs of these two diseases in combination. Perceptions of etiology and pathogenesis of AD and DD are based on similar conceptual paradigms, have multiple crossings and a number of common mechanisms including genetic. The role of genetic factors requires further study, in terms of various forms of relationship between AD and DD depending on both the disease first detected and the predominance of a psychopathological symptom complex in the structure of the depressive component. Identification of clinical features of the formation and the clinical course of comorbid pathology is necessary to study the genetic aspects of AD and DD combination, which will provide new opportunities for prevention and early detection, and will be useful for the development of personalized therapeutic approaches.