VENOUS THROMBOEMBOLISM AND COMBINED ORAL CONTRACEPTION
Objective. To carry out a systematic analysis of the data obtained in a number of investigations identifying the risk of venous thromboembolism associated with the use to combined oral contraceptives in reproductive-aged and premenopausal women. Materials and methods. The systematic review included the data of foreign and Russian papers published in PubMed and Medline in the past 10 years. Results. The paper describes the mechanisms for venous thromboembolism and outlines the concepts determining the negative effects of hormonal contraceptives on the hemostatic system. Conclusion. When prescribing combined oral contraceptives, it is necessary to individually assess the relative and absolute risk factors of venous and arterial thromboses, including premorbid diseases. Molecular genetic studies offer wide prospects to identify patients who are prone to thrombophilia.