PERSONALIZED APPROACH TO THYROTOXICOSIS TREATMENT: THE HISTORY OF DOSIMETRIC CONCEPTS DEVELOPMENT
In recent decade, nuclear medicine demonstrates a tendency towards improvement of dosimetry approaches to radionuclide therapy. Historically there were developed several methods for calculating effective therapeutic activity: prescription of standard activities (fixed activities) and personalized assessment of effective activity based on evaluation of individual radiobiokinetics, followed by the mathematical modeling. Accumulated variety of approaches to dosimetric planning of radionuclide therapy demonstrates that an optimal algorithm for calculation has not been developed so far. Developing robust pre-therapeutic dosimetric planning protocol for radionuclide therapy requires consideration of all factors (individual biokinetics, geometry, properties of radionuclide) which are independently and significantly affects target absorbed dose delivery on the one hand, and exposure of other organs and tissues, on another hand.