Genomic properties in <i>Achromobacter</i> spp. strains from cystic fibrosis patients in Russia
<b>Objective</b>. To determine species, sequence-types, antimicrobial resistance and virulence genes in <i>Achromobacter</i> spp. isolates obtained from cystic fibrosis (CF) patients in Russia. <b>Materials and methods.</b> Samples (sputum, nasopharyngeal swab) from 168 CF patients from 48 regions were studied. Whole-genome sequencing (WGS) was performed on MGISEQ-2000 platform. SPAdes software, Galaxy, ResFinder, Integrall, PubMLST were used for analysis of WGS data. <b>Results.</b> A total of 18 strains of <i>Achromobacter</i> spp. were isolated from 16 of 168 CF patients. <i>Achromobacter xylosoxidans</i> was the most prevalent and detected in 13/18 cases (72%). Studied <i>Achromobacter </i>spp. isolates belonged to 14 sequence types, including 8 new sequence types. An adaptive resistance gene carriage was a rare phenomenon (1/18 isolates). <b>Conclusions.</b> The <i>Achromobacter</i> spp. colonization rate of respiratory system in CF patients in Russia corresponds to the data reported in other countries. <i>A. xylosoxidans</i> isolates were the most prevalent (72%). <i>Achromobacter</i> spp. isolates from CF patients in Russia show a high clonal diversity.