Results of cytogenetic investigations of couples with primary and secondary infertility
Investigation of 128 married couples with primary or secondary infertility in anamnesis was performed. Changes in the karyotype were detected in 5.08% of cases. Men with primary infertility had twice the number of chromosome anomalies then women. On the contrary, individuals with secondary infertility were mostly women. More than 61% of karyotype anomalies were numerical aneuploidies of X-chromosome and Robertsonian translocations, that were present solely as der(13;14). Within the group of infertile males, such translocations were present in 50% of all karyotype aberrations and in 75% of autosome alterations. This supports the thesis about exceptional influence of Robertsonian translocations on male reproduction function. In all noted cases of balanced autosomal translocations, the chromosomes 10 and/or 13 were involved with same regions of translocations