VARIATION FEATURES OF SOLUBLE HLA CLASS I MOLECULES, CD8 ANTIGEN AND SOLUBLE COMPLEX HLA I-CD8 IN PATIENTS WITH DISSEMINATED MELANOMA DURING VACCINOTHERAPY
In this study we have examined the content of the soluble molecules HLA class I, CD8 antigen and HLA-I-CD8 complex in serum of patients with disseminated melanoma befor and after dendrtiic vaccination. We have observed that the level of HLA class I was comparable with the level of HLA class I in healthy donor. However the level of CD8 and HLA-1-CD8 was dramatically reduced. The data obtained increase our knowledge in innune response in patients with disseminated melanoma.