The superficial markers of neoplastic cell line MT-4 and perspectives of its application as a model for studying activity of immune modulating preparations
The article considers expression of markers of activation of neoplastic CD4<sup>+</sup> T-lymphocytic transplantable cellular line M T-4, transformed by T-lymphotropic human virus type I. It is demonstrated that in cells are detected such external proteins as CD25<sup>+</sup>, CD28<sup>+</sup>, CD38<sup>+</sup>, CD62L<sup>+</sup>, CD69<sup>+</sup>, CD95<sup>+</sup> and HLA-DR<sup>+</sup>. The maximal number of these components was detected in three days after transplantation of cells. These indices reached average level for markers CD25<sup>+</sup>, CD28<sup>+</sup>, CD38<sup>+</sup>, CD69<sup>+</sup>, CD95<sup>+</sup> and HLA-DR<sup>+</sup> - more than 90% and for CD62L<sup>+</sup> - 48%. The obtained results and cultivation of cells indicate that cells MT-4 can be used as a convenient model for testing of activity of immune modulation preparations.