SYNTHESIS AND STUDY OF ANTIOXIDANT PROPERTIES OF ({5-[(ALKYL(ARYL)AMINO)METHYL]- 1-ARYL-1<i>Н</i>-IMIDAZOLE-4-IL}THIO)ACETIC ACIDS
A preparative synthesis method of {[5-(alkyl(aryl)aminomethyl)-1-aryl-1Н-imidazole-4-il]thio}ace- tic acids was developed, which is based on one-pot variant of interaction between [(1-aryl-5-formylimi- dazole-4-il)thio]acetic acids and primary amines with subsequent reduction of produced imines with sodium borohydride. The structure of synthesized compounds was confirmed by elemental analysis and by results of IR-, 1H NMR and chromatography mass-spectra measurements. The study of an- tioxidant properties in in vitro experiments has shown that the produced compounds are active in concentration range between 10-1 and 10-3 moles/l. The type of substituents in the imidazole cycle doesn’t significantly influence the antioxidant effect of synthesized compounds.