HOW TO OVERCOME THE EFFECTS OF "HYPERGLYCEMIC" MEMORY?
The article considers the questions of pathogenetic therapy of diabetic polyneuropathy. Pharmacological characteristics of thiamine and its fat-soluble analogue benfotiamine are discussed. Particular attention is paid to mechanisms of action of benfotiamine from a perspective of "hyperglycemic" memory. The results of clinical evaluation of efficacy and safety of benfotiamine are presented. By the example of Milgamma compositum (benfotiamine+pyridoxine) and Milgamma (B1, B6 and B12), high clinical efficacy of a combination of B vitamins is shown; potentials for their administration for the treatment of diabetics depending on the clinical course of distal polyneuropathy are discussed.