Early Diagnosis and Treatment of Initial Stages of Carbohydrate Metabolism Disorders
The aim is to study the influence of lifestyle modification and metformin in the early stages of carbohydrate metabolism - namely, impaired fasting glucose (IFG), the process of conversion of IFG in impaired glucose tolerance and diabetes mellitus type 2.1136 people were examined. In order to diagnose the state of carbohydrate metabolism 494 subjects with risk factors for type 2 diabetes took an oral glucose tolerance test (OGTT) with 75 g of glucose. Among the 1136 people examined carbohydrate metabolism disorders were detected in 210 (18.5%). All patients with IFG (n = 90) in the absence of contraindications were given metformin. Normalization of carbohydrate metabolism in 49.4% (2008) and 60.9% (2009) of cases among individuals with IFG, confirmed by OGTT with 75 g glucose, demonstrates the need for lifestyle modification and metformin to prevent the development of type 2 diabetes.