Nature association of polymorphism gene apolipoprotein B-100 with lipid metabolism in patients with cholelithiasis
Aim - analysis of the relationship of the polymorphic variant gene rs693 APOB-100 with lipid metabolism in patients with gallstone disease and healthy individuals residing in the Republic of Bashkortostan, Ufa. Material and methods. 54 patients with gallstone disease were divided into 2 groups: group 1 - patients with chronic calculous cholecystitis (21 patients), 2 group - patients with acute calculous cholecystitis (33 patients). Analysis of the lipid profile of blood serum of patients and typing of polymorphic gene locus rs693 APOB-100. Results. It was found that for gallstone disease marker of increased risk of disease is X+X-genotype of a polymorphic variant gene rs693 APOB-100. In the serum of patients with this pathology is set elevated levels of low density lipoprotein cholesterol and a high risk of atherosclerosis. It was established relationship between disorders of lipid metabolism and gallstone disease. Conclusion. The effect of the polymorphic variant gene rs693 APOB-100 on lipid metabolism and its disorders in patients with cholelithiasis.