ATYPICAL DEPRESSION: FROM PHENOTYPE TO ENDOPHENOTYPE
This analytical review deals with clinical, biochemical and genetic characteristics of atypical depression. The authors distinguish the clinical symptoms that seem to be most biologically determined, including increased appetite, longer sleep and increased body mass. Special attention is paid to the ghrelin/leptin balance. The authors emphasize the importance of exploring the ‘ghrelin/leptin' system variability as a potential biomarker - the feature of atypical depression endophenotype that can be used for development of new approached to systematics of this disorder.