The effect of thyroid pathology on the development of sialadenosis
Salivary glands react to many physiological changes in the body, as well as to various pathological processes, including diseases of the endocrine systems. It is known that manifest forms of Hypo-and hyperthyroidism lead to irreversible changes in the salivary glands. Treatment of such patients is to compensate for the disease and achieve remission. The study of the morphological picture of the salivary glands in subclinical forms of thyroid disease would determine the etiotropic therapy of sialadenosis and sialadenitis. Purpose of research To study of morphological changes in the parotid salivary glands in subclinical forms of Hypo-and hyperthyroidism. Materials and methods The article presents experimental work on rats with modeling of preclinical forms of Hypo-and hyperthyroidism. 25 Wistar rats were divided into groups: I group - 10 rats with subclinical hyperthyroidism, II group - 10 animals with subclinical hypothyroidism, the comparison group consisted of 5 intact rats. To determine the level of free thyroxine and thyroid-stimulating hormone, blood was taken from the caudal vein. After setting the thyroid status, the salivary glands were taken, with following study of biological preparations. Results In animals of the I-th group on the 10th day on histological preparations of the parotid salivary gland functionally inactive lobules with severe lymphoid infiltration were visualized. On the 14th day in group II, retention cystic transformation of salivary gland lobules with lymphoid infiltration was revealed. Thus, there are pathological changes in the salivary glands against the background of subclinical Hypo - and hyperthyroidism. This indicates the possibility of complex treatment: correction of thyroid status by an endocrinologist at this stage.