Targeted therapy and clonal evolution in tumor diseases of hematopoietic tissue
Targeted cancer therapies are drugs or other substances that block the growth and spread of leukemia and lymphoma as well as other cancers by interfering with specific molecules involed in tumor growth and progression. Nevertheless, targeted therapies have some limitations. Chief among these is the potential for cells to develop clonal evolution as in the case of more traditional therapies. While clone evolution may contribute to resistance to therapy and prevention of clonal evolution is not always possible, monitoring of cell drug resistance ex vivo may be of additional significance.