Levels of several cytokines in serum and oral fluid in postmenopausal women with chronic generalized periodontitis and osteoporosis
In 212 postmenopausal women with moderate chronic generalized periodontitis (MCGP), of which 73 women with normal bone mineral density, 71 with osteopenia, and 68 with osteoporosis (OP), was determined the serum concentration of interleukins (IL) -1β, -4, -6, -8, -10, tumor necrosis factor alpha - TNF-α, interferon gamma - INF-γ, in the oral fluid - levels of IL-1β, IL-6 and TNF-α. In postmenopausal women with MCGP, it was found (p < 0,05) a decrease the level of IL-4 and an increase the concentrations of IL-1β, IL-6 and IL-8 in the blood serum, as well as an increase the secretion of IL-6 and TNF -α in the oral fluid. In women with MCGP against the background of OP, a decrease IL-4 levels and an increase serum IL-1β, IL-6, IL-8, TNF-α, and increase IL-6 and TNF-α values in the oral fluid are recorded. The presence of MCGP and osteopenia is combined with an increase (p < 0,05) the content of IL-6 and IL-8 in the blood serum, IL-6 and TNF-α in the oral fluid. Postmenopausal women with MCGP who do not have osteoporotic disorders are characterized (p < 0,05) by increased serum concentrations of IL-1β and IL-6, and IL-6 and TNF-α in the oral fluid.