Diagnosis of immune mechanism disorders in preterm infants using markers of T- and B-cell neogenesis (TREC and KREC) and subpopulations of T- and B-lymphocytes
To establish the stages of diagnosis of immune mechanism disorders in preterm infants, a comprehensive clinical and laboratory examination of 120 infants born at Me=33,5 (29,5-35,0) weeks of gestation was performed, determining markers of T- and B-cell neogenesis (TREC/KREC) and subpopulations of T- and B-lymphocytes.The impaired immune mechanism in preterm infants was evidenced by a persistent decrease in peripheral blood lymphocytes ≤1.0×109/l after 4 days of life; reduced or undetectable levels of T- and B-cell neogenesis markers by 37 weeks postconceptional age; and reduced lymphocyte subpopulation scores.