KARIOMETRY PARAMETERS OF HEPATOCYTES ON DIFFERENT STAGES OF FIBROSIS AND PORTAL HYPERTENSION IN PATIENTS WITH CHRONIC DIFFUSE LIVER DISEASES
Thirty three patients have been examined: in two cases in liver biopsy material there was no evidence of fibrosis, 10 persons had stage F1 fibrosis, 10 - F2, 6 - F3 and 5 - F4 in accordance with METAVIR scale. Hepatocyte nuclei area has been measured, as well as nuclear cytoplasmic relations, ellip- ticity coefficient and hepatocyte nuclei deformation factor have been calculated.Correlations between hepatocytes karyometric parameters reflect subcellular mechanisms of impairment in chronic diffuse liver diseases on different stages of the portal hypertension manifestation and liver fibrosis. Correlation between enhanced diameter of sinusoids and ag- grevation of portal hypertension manifestations has been registered.