BREEDING OF ACTIVE STRAINS OF PROBIOTIC BACTERIA WITH A WIDE SPECTRUM OF BIOLOGICAL ACTIVITY AND ANTIBIOTIC RESISTANCE
The aim of the research was the selection of active strains of probiotic bacteria with a wide spectrum of biological activity and resistance to antibiotics to create effective probiotics with targeted action against intestinal infections in humans. From the laboratory collection of lactic acid and propionic acid bacteria, the most active strains of lactic acid bacteria L. plantarum 2c / A-6, 14d, 14d / 19 and 14d / 13, L. acidophilus 27w and 27w / 77, L. brevis B-3 / A- 26 and B-3/43, L. fermentum 27 and 27A-4, L. cellobiosus 37n and 2/20 and propionic acid bacteria P. shermanii 8, antagonizing test cultures of Staphylococcus aureus, Salmonella gallinarum, Mycobacterium B5, Candida albicans, Pasteurella multocida, Bacillus subtilis, Escherichia coli 8739, Klebsiella pneumoniae ATCC 700603 and ATCC BAA 2524, Staphylococcus aureus 3316 and 9, Salmonella enteritidis 35382 and Pseudomonas aeruginosa 835. Among the selected strains, producers of hydrolytic enzymes amylase and proteinase, B vitamins, and essential and nonessential amino acids were identified. The resistance of the selected strains of lactic acid and propionic acid bacteria to the antibiotics used has been studied, which will allow, if necessary, to use them in complex therapy. Selected active strains of probiotic bacteria with a wide spectrum of biological activity and antibiotic resistance will be used to create an effective medicinal probiotics with targeted action.