Вiomarkers of renal disease at congenital malformation of urinary system in children
AIM OF THE STUDY - to optimize early diagnostics of pyelonephritis at children with congenital malformation of urinary system. PATIENTS AND METHODS. In article results of complex studying of risk factors and clinico-paraclinical features of pyelonephritis at 240 children with congenital malformation of urinary system, and also new data on level of organospecific enzymes neutral α-glucosidase and L-alaninaminopeptidase in urine at children with congenital malformation of urinary system and patients with pyelonephritis are presented. RESULTS. In this group of patients changes of a structurally functional condition of proximal and distal tubules of kidneys and indicators of intrarenal haemodynamics to a stage of demonstration of pyelonephritis are shown at children with congenital malformation of urinary system. CONCLUSION. Application of advanced diagnostics of pyelonephritis on a complex of parameters of a structurally functional condition of kidneys and a fermenturiya gives the chance to predict pyelonephritis development, to carry out its early diagnostics and timely prevention at congenital malformation of urinary system at children.