HEMATOLOGICAL PROFILE WITH A SINGLE EXPOSURE TO VARIOUS TYPES OF HYPOXIA AGAINST THE BACKGROUND OF A COURSE OF ANTIHYPOXANT ADMINISTRATION
The current work studies the effect of a preliminary course of antihypoxant Mexidol administration on the response of the hemostasis system during single exposure to hypoxic and hypercapnic hypoxia. Materials and methods. We used laboratory animals (n = 40). Rats received 30-fold daily administration of Mexidol (50 mg / kg). At the end of the 30-day training cycle, on the 31st day, the animals were exposed to heavy intensity HH (1 hour - 8000 m) or maximum intensity HH (O2 - 5%, CO2 - 5%). Results. A 30-day course of antihypoxant administration preceding a one-hour exposure to heavy-intensity HH promoted the inhibition of the platelet link, hypocoagulation of the plasma link, a decrease in the level of RCFM and an increase in the activity of fibrinolysis were noted. With a single 20-minute HH of maximum intensity at the end of the drug intake, a decrease in the aggregation function of platelets was noted, and multidirectional changes in the plasma coagulation link were recorded. In addition, there was an increase in the concentration of fibrinogen against the background of a decrease in the level of RCFM, the anticoagulant activity of the plasma increased, the fibrinolytic activity decreased. Conclusions. A single exposure to НН of heavy intensity against the background of the drug helps reduce the risk of developing a state of thrombotic readiness. A single exposure to the HH of maximum intensity at the end of the training cycle was characterized by the formation of incomplete adaptation on the part of the hemostasis system.