Significance of lymphoid infiltration of renal tissue in the development of morphological changes in patients with IgA-nephropathy according to age
Ageing is associated with progressive decline in immune system function and development of suppression of immune response. It is shown that this background in the elderly increases the frequency of infectious, autoim- mune diseases and cancer. In our study analyzed the eﬀect of subpopulation composition of lymphoid inﬁltration in renal tissue in patients with IgA-nephropathy according to age (1 gr. - up to 59 years, 2 gr. - аfter 60 years of age). The paper shows that in the older age group there was a signiﬁcant decrease in the number of TdT +-cell inﬁltrate in the glomeruli, which indicates that a violation of regenerative processes, progressing from the patient’s age. Also shown acceleration of apoptosis of mononuclear cells of lymphoid inﬁltration in Group II patients. The features of subpopulations of patients with older age groups, indicating the depletion of mature germ lymphopoiesis and the development of immunosuppression in patients in old age. Shown signiﬁcant inﬂuence of lymphoid inﬁltration on the morphological changes of kidney tissue in patients with IgA-nephropathy according to age.