ENDOCELLULAR METABOLISM OF NEUTROPHILS AT ADIPOSITY
The study was parameters endocellular metabolism of neutrophils in 59 men aged 29-64 years without ischemic heart disease. In 16 (27.1 %) patients have been revealed II-III degree of obesity which presence was accompanied by increase level of C-reactive protein and uric acid in blood on background of decrease activity of catalase in neutrophils. The least activity catalase in neutrophils and the greatest level of uric acid in blood came to light at III degree of obesity. The given changes of endocellular metabolism in neutrophils were accompanied also by growth of the contents of hydrogen peroxide and reduction activity of glutatione reductase in phagocytes. It is possible to believe, that activation of chronic inflammation at presence of obesity associates with increase in neutrophils formation of hydrogen peroxide which maximal growth on background of significant reduction of endocellular activity of catalase in patients with the expressed obesity can promote development of oxidative stress and increase in risk of cardiovascular complications.