Life Cycles of Bone Marrow Hematopoietic Stem Cells
Hematopoietic stem cells (HSC) are self-renewing and capable of differentiating into all types of blood cells. HSCs are a rare and heterogeneous population. The functional state of the HSCs are provide of several specialized niches. This review focuses on the specialized microenvironment of the HSCs, mechanisms of regulation of quiescence, cell cycle and apoptosis of the HSCs.