PLASMA CYTOKINES IN ERYSIPELAS
Background. Erysipelas is a relatively common and a socially significant disease. The role of pro - and anti - inflammatory cytokines in the development of primary erysipelas or its recurrent course remains understudied. Aim. To assess blood concentration of cytokines status among primary and recurrent erysipelas as well as among healthy controls. Methods. A case-control study. Altogether, 90 patients with erysipelas and 90 controls were studied. All the participants of study were ethnic Kazakhs. In all patients and controls IL-1β, IL-4, IL-10 and IL-17A cytokines were determined in blood plasma. Statistical analysis was performed using Mann-Whitney tests with Bonferroni correction. Results. Patients with erysipelas had higher levels of IL-1β and IL-17 compared to healthy controls ( P = 0,006 and P = 0,004, respectively). The level of IL-10 was lower in patients with erysipelas than in healthy controls ( P = 0,004). The differences in IL - 4 in did not reach the level of statistical significance ( P = 0,063). However, the concentration of IL-4 among patients with recurrent erysipelas was lower than in patients with primary erysipelas ( P = 0,014). Conclusions. Our study suggests that there is an overproduction of pro-inflammatory IL-1β and IL-17A and underproduction of anti-inflammatory IL10 among erysipelas patients while IL4 are lower in patients with recurrent erysipelas than among primary patients among ethnic Kazakh population.