Effect of immune modulators in different combinations on luceginine-dependent chemical luminescence in the blood alveolar and peritoneal macrophages
In vitro the blood alveolar and peritoneal macrophages can be assessed as systems with limit possibilities for evaluation of antioxidant properties of immune modulators because we can assess only antiradical (anti-superoxide О2•) effect of them in these systems. Immune modulators in fifferent concentrations (0.1-20 mM) can induce prooxidant or antioxidant effect in these systems. The blood alveolar and peritoneal macrophages differentially react on adding of immune modulators with proved systemic antioxidant properties (metaprot, trekresan, polyoxydonium). Combination of immune modulators increases the possibility of appearance of intiradical properties in these cellular systems.