KSEFOKAM IN ODONTOGENOUS PERIOSTITIS AT ELDERLY AND SENILE PATIENTS
We examined 68 patients aged 32-83 years (average age - 61,83 ± 14,73 years) with acute jaw odontogenous periostitis before treatment (in exacerbation of the disease) and during a combined therapy by Ksefokam. It was found that treatment by Ksefokam accelerated inflammation regression and recovery. A high analgesic activity of Ksefokam in this disease was noted. Ksefokam was the most effective drug in elderly and senile patients. An opportunity of using definition of melatonin concentration in saliva as a marker of inflammation regression was showed. High concentration of melatonin in saliva in exacerbation of inflammation is an important prognostic criterion for the disease outcome. A higher level of melatonin in saliva was found in elderly patients, who had endured the Siege of Leningrad in childhood, compared with those one of similar age, who had not subjected to multifactor stress effects in childhood.