BLOOD GLUCOSE LEVEL IN EXPERIMENTAL MODELING OF PHYSICAL DEPENDENCE ON ALCOHOL AGAINST THE BACKGROUND OF L-CARNITINE USE
The great significance of alcoholism in the medical and social aspect serves as an important starting factor for evaluating the effect of various drugs on metabolic processes in the body when exposed to excessive amounts of ethyl alcohol. The critical moment in alcohol dependence is considered to be the formation of alcohol withdrawal syndrome. The set of changes in metabolism determines the occurrence of a hypoenergetic state of cells in these conditions. Therefore, in the aspect of corrective measures to eliminate metabolic disorders in alcohol intoxication and alcohol dependence, the most important importance is given to restoring the energy potential of cells, restoring the level of ATP. In the conditions of ethanol withdrawal, termination of its action, and reduction of the inhibitory effect of acetaldehyde on the components of the electron transport chain of mitochondria, the need to use all energy substrates with maximum efficiency becomes particularly important. In this regard, the action of carnitine is of interest. The publication provides information on the content of glucose in the blood serum during the formation of the ethanol withdrawal reaction under the conditions of L-carnitine use. L-carnitine has been shown to reduce blood glucose levels in animals treated with carnitine alone when compared with a control group. The concentration of glucose in the blood increases with the simultaneous administration of ethanol and L-carnitine in the conditions of comparison of data with animals that received only L-carnitine. These changes may be associated with impaired functioning of the neurotransmitter and hormonal systems of the animal body in conditions of severe, forced alcoholism.