THE STUDY OF THE EFFECTIVENESS OF DRUG PREVENTION MECHANISMS OF CARDIOVASCULAR AGING BY CYTOFLAVIN
The aim of the research was the search of the mechanism of Cytoﬂavin action in patients with isolated systolic arterial hypertension (ISAH) as the aging model. The following research methods were applied: the assessment of complaints, 24-hour arterial pressure monitoring, ultrasound diagnostic, volume sphygmography, lipid proﬁles and coagulogram, molecular phenotyping by MALDI-TOF-TOF-MS. The combination of Cytoﬂavin with standard therapy of ISAH led to the most expressed return development of clinical symptoms, the restoration of the haemodynamics, structural and geometrical parameters of cardiovascular system, indicators lipid proﬁles and coagulogram in the comparison with patients with ISAH, who accepted standard therapy and those of the control groups. Molecular mechanisms of Cytoﬂavin action, including regulation of the activity of cell signaling pathways through intermolecular interactions were found. We recommend using Cytoﬂavin together with the standard therapy in treatment of ISAH, which provides the action of geroprotectors for cardiovascular system.