IMMUNOGLOBULIN G4 RELATED DISEASE
Publications dedicated to the immunoglobulin G4 related disease (lgG4 related disease) have been reviewed. The basic concept of the pathology is presented and the diagnostic criteria and the disease terminology are described. The disease epidemiology is considered. The lgG4 related disease clinical manifestations, the symptoms of the pancreas, hepatobiliary tract, salivary glands, eyepit, lymph nodes, retroperitoneal cellular tissue, aorta, mediastinum, soft tissue, skin, central nervous system, breast, kidneys, prostate, lungs, upper respiratory airways, thyroid disorders are described in detail. The characteristic laboratory tests changes are specified. The immunohistochemical assay accompanied by the lgG4 + plasmatic cells quantitative determination is stressed to be extremely important for diagnosing the lgG4 related disease. The current approaches to the lgG4 related disease are described. Glucocorticoid administration is shown to be the base of the lgG4 related disease management. The aspects of the lgG4 related disease management are being discussed.