Prostaglandins and their role at early stages of embryonic development (review)
Aim. A brief analysis of scientific publications on the role of prostaglandins at early stages of embryonic development has been carried out.Results. In the process of studying the literature data, both national and, for the most part, foreign authors, the role of prostaglandins was established as paracrine factors involved in an increase in vascular permeability and angiogenesis, mediating the effect of gonads and the expression of growth factors (vascular endothelial growth factor, angiopoietin) during implantation and decidualization. The effects of prostaglandins on the degradation and remodeling of the extracellular matrix of the uterus are described. The role of prostaglandins in the transportation of gametes and embryos is shown. Information on the role of prostaglandins in the growth and development of blastocysts, as well as trophoblast invasion, is presented.Conclusion. The understanding of the role of prostaglandins at the early stages of embryonic development is far from complete. Despite active research in this direction, scientists still have many questions regarding the mechanisms of action, the functions of prostaglandins at the initial stages of embryogenesis. Most of the information has come from animal studies, mainly rodents. Therefore, to further study the mechanisms underlying the diverse action of prostaglandins on multiple processes of embryogenesis, it is necessary to carry out additional studies in humans.