Current Focus on Nosogenesis of Type 1 Diabetes Complications, the Role of Antioxidant System
Study Objective: To evaluate the role of polymorphism of antioxidant genes in formation of type 1 diabetes and its chronic complications. Key Points: The information from literature is provided regarding researches of polymorphism of genes coding the enzyme activity with antioxidant effect and their correlation upon development of microvascular complications of type 1 diabetes mellitus. Conclusion. The analysis of results of published researches evidences of the necessity to study the peculiarities of functioning of various components of antioxidant defence for type 1 diabetes patients, depending on onset age, length of disease, and diabetes compensation.