Molecular and genetic mechanisms of predisposition to osteoporosis
Osteoporosis is a systemic metabolic disease of the skeleton, characterized by decreased bone mass and micro damages of bone tissue that leads to an increased risk of fracture. Homeostasis of bone tissue during lifetime is maintained mainly by balanced processes of bone resorption and formation, controlled by a large quantity of genes and environmental factors. The identification of genes variants, responsible for predisposition to this disease, will help to form groups of risk and to perform the most effective measures of prevention, diagnostics and therapy of such patients, which will allow avoiding complications and decrease mortality and disability.