Consistency etiopathogenetic therapy on outcome of pulmonary tuberculosis in patients with human immunodeficiency virus
We have studied the efficiency of multimodality treatment in patients with pulmonary tuberculosis concurrent with human immunodeficiency virus. It has been detected that 93,6% of patients on admission had organism homeostatic balance disorder. In more than a half patients homeostatic balance disorder was followed by significant and deep disturbances (3d and 4th degree), occurring with inadequate adaptation reaction types. Multimodality treatment of the patients improved the organism homeostatic balance indices. At the same time frequency of the 3d and 4th disturbance degree appearance was reduced to 12,7%. Frequency of the pathological organism reactivity ectypes (hyporeactive and areactive types) was reduced to 4,7%. The positive homeostasis dynamics in patients during the specific treatment lead to the treatment efficiency increase. Assessing the x-ray control on the respiratory system the efficiency was shown by increase of small and moderate residual tubercular changes to 78,2%. According to the results of the multimodality treatment held, frequency of the formation of the small and moderate residual tubercular changes in the end of the basic treatment course was the same in patients with comorbid pathology and tuberculosis patients with no human immunodeficiency virus. These results show the importance of the of the personified activation pathogenetic therapy inclusion into such patients' healing process, for it improves adaptation, homeostasis, organism reactivity and treatment efficiency by increasing frequency of the inadequate types of the adaptation reactions and reducing frequency of the pathological organism reactivity ectypes. Small and moderate residual tubercular changes formation in the respiratory system helps to prevent tubercular process aggravation (relapse) in patients and improves their life quality.