Premature ovarian failure and cardiovascular diseases
The impact of estrogen deficiency in women with timely menopause on the risk of cardiovascular diseases (CVD) is now widely discussed. However, there are very few papers dealing with this problem in female patients with premature ovarian failure (POF). Objective. To summarize the data of current clinical trials of the problem of CVD development in women with POF. Subject and methods. Good-quality bibliographic references published in the PubMed database on the studies of surrogate markers and endpoints for the development of CVD in women with POF were reviewed. Results. Analysis of the performed investigations has shown that POF-induced estrogen deficiency is a significant and traditional CVD risk-independent predictor of coronary heart disease and strokes, the relative risk of which in this pathology is 2.11 and 2.10, respectively. Conclusion. To confirm the significant role of POF-induced estrogen deficiency in the development of CVD, it is necessary to conduct large-scale randomized controlled trials, by not only thoroughly analyzing the predictors of CVD, but also by necessarily accounting cardiovascular events in this category of patients.