HEMOSTATIC STATUS IN DRUG-INDUCED ABORTION
Objective. To evaluate the safety of using the analogues of mifepristone and misoprostol for the interruption of early pregnancy, by def ining the combined effects of the drugs on the hemostatic system. Subjects and methods. Questioning, general clinical examination, dynamic biochemical and hematological studies, and determination of basic vascular and thrombocytic, coagulant, antiacoagulant, and fibrinolytic parameters of the hemostatic system were done in 65 women who had undergone drug-induced abortion. Results. The patients with drug-induced abortion have the changes in blood parameters in the reference range, which are indicative of the higher activity of hepatic enzyme systems and the compensatory enhancement of the blood clotting potential, and impairments in platelet disaggregation processes. Blood anticoagulant and fibrinolytic activities tend to reduce slightly in the reference range of the mean activity values for AT II and protein C and to prolong the spontaneous lysis of euglobulin clots 3—4 days after abortion. Most blood parameters are normalized by day 10 postabortion. Conclusion. Pharmacological abortion in early pregnancy exerts a sparing effect on the hemostatic system with the reserve abilities being preserved.