СOMPARATIVE ANALYSIS OF CYTOKINES IN SALIVA AND BLOOD AT THE EARLY PHASES OF STABLE CHRONIC OBSTRUCTIVE PULMONARY DISEASE
The objective was to study comparative analysis of cytokines in saliva (focal) and blood (systemic inflammation) at the early phases of stable chronic obstructive pulmonary disease (COPD) to identify immunological aspects of COPD pathogenesis in smokers. A cohort of patients with early forms of COPD (144 individuals) employed at the radiochemical facility was constantly followed up for the recent 15 years. The study included 33 individuals from the main group and 10 control individuals, who worked in the same conditions, matched by age and gender. The pro-and anti-inflammatory cytokines were analyzed in saliva and blood serum from patientswithearlyformsofCOPD.Therevealedincreaseofpro-inflammatory cytokines both in saliva and blood serum was not compensated by increasing anti-inflammatory cytokines.