GENETIC ASPECTS OF ALLERGIC DERMATOSES
The analysis of polymorphism of SPINK-5 gene and loss-of-function mutations in FLG gene of patients with allerodermatoses presented. The method of the length restriction fragments polymorphism was used for the analysis. The association between genotypes AA and GG of SPINK-5 gene and allergic dermatoses was shown in the work (genotype AA causes high-risk, and genotype GG – reducer risk of occurrence of these pathologies). While analyzing the mutations in FGL gene (R501X and 2282del4) the reliable difference in 2282del4 heterozygotes between sick people and group of healthy donors was shown. Data demonstrate importance of the genetic factors in development of allergic dermatoses, because both genes revealed reliable correlation with these diseases.