Markers of neuron and astrocytes damage in the blood serum of newborns with different degree of cerebral ischemia
Research of permeability of the hematoencephalic barrier in the blood serum of newborns with different degree of hypoxic-ischemic damage of the central nerves system (CNS) was conducted using a quantitative dynamic immune-enzyme analysis of neurospecific enolase (NSE), gliofibrillar antigen (GFAP) and sFasL. It was established that increase of the level of NSE in the blood serum can be additional criterion for early diagnosis of perinatal hypoxic-ischemic damage of CNS and for evaluation of a lesion degree. Enhancement of the maintenance of GFAP in the newborn blood serum should be considered as a marker of hypoxic-ischemic damage of CNS degree