THE TRAUMATIC BRAIN INJURY MODELING BY THE "WEIGHT-DROP METHOD"
The work is devoted to describing the modeling of traumatic brain injury in animals by free drop shipping with subsequent evaluation of the functional and structural changes. The study used biochemical, morphological and behavioral approaches in two groups of animals. As a result of histological tests had revealed damage to the meninges and the brain substance. Biochemical analysis allowed to fix depression of antioxidant enzymes and accumulation level of lipid peroxidation products. These tests "open field" and "elevated plus maze" to reflect the presence of psycho-emotional and locomotor disorders resulting from traumatic brain injury. The data obtained shows the development and the presence of traumatic brain injury in experimental animals (rats) and, consequently, a new methodical approach can be considered valid.