SPECIAL FEATURES OF REMODELING OF THE SUBCHONDRAL BONE IN OSTEOARTHRITIS WITH COMORBIDITY
Aim. To characterize the features of remodeling of the subchondral bone (SCB) in patients with osteoarthritis (OA) with different levels of comorbid status using texture parameters. Material and methods. The study included 92 patients with stage I-IV OA of the knee according to Kellgren aged (66,1±10,5) years. Control group included 24 volunteers aged (29,6±5,96) years without clinical or radiological signs of OA. Patients with OA were divided into groups with «low», «moderate», «high» comorbidity and «metabolic phenotype» OA. Textural characteristics were evaluated by our own methodology. Results and discussion. The presence of radiographic evidence of OA directly correlated with the level of comorbidity. There is a statistically significant correlation between the age of patients with OA with comorbidities and the presence of cardiovascular events in the form of heart attacks and strokes. The volume of distribution of pixel values relative to the average value of grayscale tones (SDG) was significantly lower in patients with OA. The number of maximum peaks (EM) was significantly lower in patients with OA. Minimum peak on 3D-histogram (MinP) was significantly higher in OA and toning pixel row spacing in SCB was lower than in the control group. Conclusion. Our data indicate that SCB remodeling occurs in OA. Identified changes are more dependent on comorbid conditions. They give the prerequisites for pathogenetically justified classification of OA patients, depending on the presence of cardiovascular and metabolic diseases. Proposed methods of visual assessment are based on mathematical multidimensional analysis can be attributed to their potential diagnostic markers of OA on the basis of which discrimination of patients by the type of changes taking place in the SCB can be carried out. Proposed methods require morphological comparisons and clarification of the diagnostic value.