INFLUENCE OF BRAIN-DERIVED NEUROTROPHIC FACTOR BDNF LEVEL ON PSYCHOVEGETATIVE STATUS AND NEUROPSYCHIATRIC DISORDERS IN MEDICAL STUDENTS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA
The results of studying the state of the autonomic nervous system, the features of the psychoemotional status and non-psychotic mental disorders with different levels of brain-derived neurotrophic factor (BDNF) in 80 ASMU students with and without undifferentiated connective tissue dysplasia (UCTD) are presented. According to the level of BDNF in the blood serum, all subjects were divided into 3 groups: with the normal (control group, n=32), low (group 1, n=25) and elevated levels of BDNF (group 2, n=23). A decrease in BDNF levels is associated with severe UCTD and is accompanied by a higher level of situational anxiety, the frequency of severe non-psychotic depression, introversion and Internet addiction, as well as a lower level of emotional intelligence. In the group with elevated neurotrophin, the indicators of autonomic dysfunction, severity of headache, asthenia, and neurosis were higher. A positive correlation of BDNF with personal anxiety and the index of the influence of headache, UCTD with autonomic dysfunction syndrome (ADS) and depression were found. The authors suggest that the inclusion of UCTD correction for treating patients with non-psychotic mental and psycho-vegetative disorders will improve the results of therapy, improve the quality of life and psychological adaptation of young people.