Morphological Presentation of Osteogenesis in Experimental Application of KOSTMA Osteoplastic Material
Objective. Stady of new composite material with plastic consistency having an osteostimulative and local antibacterial effects; experimental study of the material efficacy. Material and Methods. Experiments were performed in 36 mature male rats aged 5-6 months. The first series of experiment included the study of osteogenesis processes in induced bone defects without application of osteoplastic material. In the second series the bone defects were filled with Kostma - a new osteoplastic material. Experimental and morphological techniques were used in research. Osteogenic process was studied in histological specimens stained with hematoxilin-eosin and van Giesons in 14, 30, and 90 day after operation. Results. In the first series a formation of osteoid bone regenerate with spongy structure from periphery to the center of defect was observed at all observation terms. The second series of the experiment showed the process of osteoclastic resorption and osteoblastic osteogenesis on the basis of Kostma osteoplasic material at all observation terms. Conclusion. The study has proved that Kostma composite osteoplastic material can serve as a matrix for bone formation.