SOME INDICATORS ANTIOXIDANT PROTECTION IN PLASMA AND RABBIT LIVER
Determined enzyme activity and content of the antioxidant system (glutathione peroxidase (GPO), glutathione content and ceruloplasmin in plasma and liver tissue) in the body of the New Zealand breed rabbits on the background of the biochemical impact of vitamin mineral additives in the experimental group and its absence - in the control group. In rabbits from 45 to 60 days old plasma research group observed a tendency to increase the activity of glutathione peroxidase. On the 75th day observed reduced activity of the enzyme in rabbits experimental group. In the experimental group of rabbits 90 days old were registered significant increase of 11,2 % glutathione peroxidase activity compared with animals in the control group. This phenomenon may be due to the combined effect of biologically active substances vitamin and mineral supplements to stabilize the antioxidant processes in the plasma of rabbits experimental group. The activity of glutathione in the liver tissues of rabbits in the control group aged 45-, 60-, 75- and 90-days tended to a gradual increase in performance, but they were lower compared with the research group. In the study of glutathione content in the liver of rabbits in the control group 60 days old were recorded higher content 2.3 times compared to the animals 45 days old. In the experimental group were also likely increase glutathione in the liver tissues of rabbits 60 days old compared to 45 daily. The highest content of ceruloplasmin found in plasma of rabbits in the control group 60 days old which was 0,533±0,017 mg/dm<sup>3</sup>. Established reduction of ceruloplasmin in plasma of rabbits experimental group of 45 to 75 days old. Next 90 days age again observed increase in the content of ceruloplasmin in rabbits experimental group. In liver tissue of rabbits experimental group 45 days old ceruloplasmin content was higher compared to 60 animals daily age.