Epidemiology, pathogenic features and clinical factorsof thrombosis in patients with Ph-negative myeloproliferative neoplasm
Decades of laboratory and clinical studies allowed identifying the key pathogenetic links of thrombosis in patients with Ph-negative myeloproliferative neoplasms, namely: the breach expres- sion of membrane glycoproteins and the platelet hyperactivity, the proinflammatory phenotype of leukocytes and the leukocyte-platelets interaction. Unfortunately, at present identified a limited number of independent clinical risk factors for thrombosis. The age over 60 years and the previous thrombotic episode in history of patients is the proven factors of the development of thrombo-sis in patients with polycythemia vera and essential thrombocythemia. Recently, more attention is paid to the study of disease associated predictors of thrombosis, the most promising of which is leukocytosis and positive JAK2 V617F mutational status. This new data provide a broad space for a further study of determinants of the aсquired thrombophilic syndrome formation in patients with Ph-negative myeloproliferative neoplasms.