Micro- and - ultrastructural changes in subcapsular layer in acute period of thymus after experimental hyperthermia
The aim of research was to study the 45 Vistar rat thymus' cellular composition aft er the experimental hyperthermia (EH). Th e animals were heated only once to thermoplegia. During diff erent periods (5 hours, 3 days aft er EH) the animals were killed aft er light narcosis, then thymus was taken for further research. Histologic specimen were produced according to basic methods. Immunoblasts were diff erentiated in subcapsular zone of thymus. Also there were middle and small lymphocytes, cells with mitosis' shapes, cells with pyknotic nuclei, epithelial cells and macrophages (1000 times expansion on the standard area 4500 mkmІ). It has been established, that infl uence of the EH on the rat organism leads to formation of accidental involution of thymus. Involution of this organ corresponded to the «catabolic» phase of the posthyperthermal period (5 hours, 3 days aft er EH) that was expressed in decrease of relative weight of the organ (25 %), reduction of the relative area of cortex (15 %) and density of lymphocyte (12 %). Strengthening of destructive processes at a tissue level, attributes of perivascular hypostasis, migration of cellular elements in lymphatic spaces and capillaries were marked.