PATHOGENETIC RELATIONSHIP OF INFLAMMATORY PERIODONTAL DISEASES WITH GASTROESOPHAGEAL REFLUX DISEASE
Article is devoted to the identification of new diagnostic criteria of inflammatory periodontal diseases (IPD) on the background of GERD based on analysis of clinical, laboratory, morphological and immunohistochemical methods. The study was conducted among 160 patients: 60 patients with IPD against NGERB on the background; 40 patients with IPD on the background EGERB; comparison group – 40 patients with IPD without oesophagus pathology and 20 healthy persons. The result revealed that gingivitis and periodontitis develops against the backdrop of increased number of indicators of NO-synthase and endothelin-1 immunopositive cells. Periodontitis moderate and severe hypoplasia develops in the melatonin immunopositive cells. Periodontal disease on the background of GERD have expressed changes in the components of the diffuse endocrine system. Thus, the nature of periodontal lesions is largely determined by opposite changes of components of diffuse endocrine system. GERD is a risk factor and an unfavorable course of inflammatory periodontal diseases.