CLINICAL AND ECONOMIC EVALUATION OF THE EFFECTIVENESS OF THE USE OF NUMETA IN THE TREATMENT OF NUTRITIVE DEFICIENCY IN CHILDREN UNDER THE CONDITIONS OF THE REPUBLIC OF KAZAKHSTAN
Relatively recently, three-chamber containers have appeared on the market for parenteral nutrition (PN) preparations, containing ready-made nutritional components for newborns in each container, which theoretically reduces the risk of infection and facilitates use. Purpose of the study. Clinical and economic evaluation of the effectiveness of the use of the drugs Numeta G13E and Numeta G16E in the treatment of nutritional deficiency in the conditions of the intensive care unit of newborns of the Republic of Kazakhstan. Material and methods. In the course of the study, an analytical decision-making model was built in MS Excel, which made it possible to conduct clinical and economic analysis and budget impact analysis of the use of drugs Numeta G13 and Numeta G16 for parenteral nutrition of newborns in the typical clinical practice of the Republic of Kazakhstan. To study the influence of the variability of the developed model parameters on the modeling outcomes, a univariate multicomponent sensitivity analysis was performed. For the selected parameters, an uncertainty level of 20% was used. Results and discussion. The use of the ready-made Numeta G13E container for parenteral nutrition of preterm infants, compared with the option of using the individually prepared mixture in hospital, allows to save Healthcare budget from 3 (when using deeply premature infants for PN) to 51 million tenge per year (when used in a common cohort of premature infants). The use of the ready-made Numeta G16E container for parenteral nutrition of full-term infants, compared with the option of using an individually prepared mixture in hospital, allows to save Healthcare budget from 1 (savings in the treatment of newborns with necrotizing enterocolitis) to 48 million tenge per year (when treatment of newborns with intestinal insufficiency syndrome). Conclusions. Using for parenteral nutrition of newborns (both full-term and premature) a ready-made Numeta container containing an emulsion for infusion, is pharmacoeconomically more appropriate than using an individually prepared mixture in hospital environment.