Metabolic Changes of Biochemical Indices at Local and System Levels in Patients with Allergic Diseases
This study shows the changes in the detoxification system function, antioxidant system function and the intensity of free radical processes in the oral fluid and blood in patients with allergic diseases such as atopic dermatitis and bronchial asthma. Both groups of patients revealed the intensification of free radical oxidation, disbalance in the functioning of the antioxidant defense system that manifested in the increase of catalase activity (1.3-1.4 times) and glutathione reductase (2,7-11.1 times) and reducing the activity of glutathione peroxidase (3.0-3.7 times). Superoxide dismutase activity changed in different directions - in patients with atopic dermatitis it decreased (by 1.4 times), in patients with asthma it increased (1.6 times). The antioxidant activity of blood and oral fluid was decreased. In addition found significant violations in detoxification system. The results of content medium and low molecular weight showed the presence of endogenous intoxication. Analysis of received biochemical parameters showed positive correlation between changes in blood and oral fluid of patients, indicating a promising application of non-invasive diagnostic method of assessing metabolic status in patients with allergic diseases. Obtained data extend the understanding of the pathogenesis of disease that offers the prospect of finding new diagnostic criteria and methods for their correction.