INVESTIGATION OF DRUGS' ADSORPTION BY THE PERFLUORANE
<i>Objective: </i>to estimate the perfluorane adsorption capacity of the drugs belonging to different pharmacological groups. <i>Materials and methods. </i>The binding of perfluorane to 50 drugs at concentrations of 12.5 to 100 <i>μΜ </i>was studied <i>in vitro </i>using equilibrium dialysis. <i>Results. </i>Interactions of ligands with the particles of perfluorane emulsion were found to be of three types. Type 1 substances were characterized by negative affinity to perfluorane; type 2 ligands acted indifferently with the emulsion; type 3 compounds were reversibly adsorbed with the particles of the blood substitute by the affinity constants ( <i>K</i><sub><i>a</i></sub><i>ff) </i>of 10<sup>4</sup> M<sup>1</sup>. <i>Conclusion. </i>The perfluorane adsorption capacity is ambiguous and seems to depend on the properties of ligands. Type 3 interactions, which may lead to an increase in blood adsorption capacity and change in the pharmacokinetics of drugs used in combination with perfluorane, appear to be the most important.