EFFECT OF INTRAGASTRAL AND PARENTERAL INJECTION OF ZINC CHLORIDE ON ELECTROLYTE- AND WATER- EXCRETORY FUNCTION RENAL OF EXPERIMENTAL HYPOCALCIEMIA
The aim of the work was to study the effect of hypocalcemia on the changes of renal function in intragastric and subcutaneous administration of zinc chloride. Work was carried out on 60 male Wistar rats weighing 200 - 300g. Model of experimental hypocalcemia in rats was induced by daily subcutaneous injection of " Miacalcik " at a dosage of 0.6 g ED/100 every day during 20 days. Zinc chloride was administered intragastrally and subcutaneously at a dosage of 20 mg / kg daily for 30 days. Investigation revealed that hypocalcemia model obtained by subcutaneous administration of calcitonin in combination with both intragastric or parenteral intake of zinc chloride was characterized by a more significant effect of metal on the kidneys.Changes in electrolyte- and water-excretory function of kidneys in conditions of intragastric and subcutaneous. administration of zinc chloride were similar.