SIDE EFFECTS OF MEDICINES OF THE GLYCYRRHIZA (REVIEW OF LITERATURE)
The review of literature on side effects of medicines of a glycyrrhiza is provided in article. Long administration of drugs of a glycyrrhiza can lead to violations of water-salt exchange, hypostases. Headaches, skin reddening can sometimes be observed. Long reception of a glycyrrhiza can lead to a syndrome similar which was found in primary giper-aldosteronizm. The psevdoaldosteronizm caused by a glycyrrhiza develops because of inhibition of enzyme 11fi-gidrosteroid of a degidrogenaza 2 (11fi-HSD2) which leads to accumulation of cortisol in tubular epitelialny cages which activate mineralcorticoid receptors, stimulate release of potassium which leads to a gipokaliyemiya. Medicines of a glycyrrhiza are contraindicated at pregnancy as glycyrrhizin stimule affects uterus muscles. At mothers using medicines of a glycyrrhiza - the been born girls had big tendency to obesity, at boys cognitive functions developed worse. There are observations of early manifestation of a preeklampsiya, in connection with the use of a root of a glycyrrhiza. Also the gipermineralocortikoidizm a similar syndrome at which the hypertension, Printsmetall ischemia, a gipokaliyemiya, metabolic alcaloz and a gipoaldosteronizm is observed can be observed. Researches have shown that two-week consumption of a root of a glycyrrhiza increases ekstratsellyulyr amount of liquid, increases the central systolic and diastolic arterial blood pressure.