Status of vitamin D in the food protein induced enterocolitis syndrome in children
Aim of the study. To study the status of 25 hydroxyvitamin D in case of food proteins induced enterocolitis syndrome in young children and to determine the relationship between its level and clinical and laboratory manifestations of the disease. Materials and methods. 72 children with Food Proteins Induced Enterocolitis Syndrome aged from 3 months to 3 years were examined. To confirm the diagnosis, clinical-anamnestic, paraclinical (general blood analysis, coprology, feces for latent bleeding, total protein), and immunological (IgE total, IgE-specific antigen-specific method, lymphoquin-producing ability of T-lymphocytes to food allergens) were used. For studying the status of vitamin D in the serum of sick children 25 (OH) D3 was determined. Results. The average values of vitamin D in children with gastrointestinal food allergies had marked differences in comparison with the norm. Thus, in children with FPIES, they were 20.0 ± 4.4 ng / ml, at a rate of 45.1 ±8.04 ng / ml. Lower vitamin D values occurred in children with more severe clinical manifestations of the disease and, in part, with association with Ig E. By criteria, vitamin D deficiency was found in 41.6% of children with FPIES, insufficiency in 18% of children, in 29 (40.2%) cases, the rates were within the normal range. Conclusion. Thus, it was founded a decrease in the vitamin D values by 2.25 times in food protein induced enterocolitis syndrome, compared with the norm, which dictates the need for the children with FPIES to make aqueous solutions of vitamin D.