COFFEE AND HUMAN NERVOUS SYSTEM (LITERATURE REVIEW)
Coffee stands in second place in terms of frequency of consumption, after tea. The effects of caffeine on the CNS, mainly through antagonism of adenosine receptors and subsequent modulation of dopaminergic activities. Due to the psychostimulatory properties, coffee intake reduces the risk of developing depression, but its effects are insufficient to provide therapeutic effects in depressive disorders. Taking high doses of caffeine can lead to thymic disorders, worsen circadian profiles and signs of anxiety. A large number of studies have shown the presence of neuroprotective properties in coffee, caffeine-containing products. Coffee consumption has therapeutic effects in diseases such as Parkinson 's disease, Alzheimer 's disease and lateral amyotrophic sclerosis. Taking coffee reliably reduces the risk of developing depression and dementia mainly in men, without showing such results in women. Drinking coffee inversely proportional to the incidence of Parkinson 's disease, reduces cognitive impairment in this disease. Clinical studies have shown that consuming large amounts of coffee early in pregnancy (15 weeks) leads to frequent behavioral disorders in children (under 11 years of age), after birth. Coffee has antidepressant properties. Taking coffee for more than 4 mugs a day and using synthetic sweeteners increase the risk of depression.