The use of combined drugs for the treatment of patients with acute dorsalgia
Musculoskeletal pain syndromes, in particular dorsalgia, are a common cause of seeking medical care. Timely relief of acute dorsalgia reduces the risk of adverse events and prevents the formation of chronic pain syndrome. The review, based on data from randomized trials, meta-analyses, and systematic reviews, discusses the efficacy and safety of the most widely used NSAIDs and paracetamol for acute pain relief. Special emphasis is placed on adverse events, including those from the cardiovascular system, gastrointestinal tract, liver, the risk of which depends on the prescribed dose and regimen duration. The possibility and expediency of their combined use (including as part of a combined drug containing low doses of paracetamol and diclofenac, which complement each other’s effects) are separately considered. The results concerning the prescription of this combination, which demonstrated the treatment efficacy and safety, are presented.