The concept of hypobiosis and problem of nanomateriais biosafety
The role of methabolic depression state of cells (hypobiosis) in potential toxicity of engineered nanomaterials and it's using in engineering of cell biosensors are discussed. The membrane potential as regulative point of cell physiology is considered to determine the cellular state perturbed by interaction with nanoparticles. The membrane potential is convenient indicator of cell state in hypobiosis. The hypobiosis induced by chemical substances increases the resistance of microbes to stress factors affected by biocide nanoparticles. The latter must be taken account of searching criteria of biosafety in manufacturing and application of nanomaterials.