PREDICTION OF PURULENT WOUNDS HEALING BASED ON IMMUNOCYTOCHEMICAL IDENTIFICATION OF PROTEINS SYNTHESIS EXPRESSION, USING DIFFERENT METHODS OF TREATMENT
The aim of the study was to substantiate the prognosis of purulent wound healing based on expression of the synthesis of the proapoptotic protein p53 and the Ki-67 protein - the proliferation marker, as result of different treatment methods, against the background of alloxan diabetes. The therapeutic efficacy of Miliatsil and EHF-therapy was studied in experiments on 128 white mongrel male rats, with simulated purulent-inflammatory nidus against the background of alloxan diabetes. The results of the study conducted are indicative of the fact that the combined use of Miliatsil and EHF-therapy was most effective. The obtained experimental data have been confirmed by the immunocytochemical studies of purulent wound tissues against the background of alloxan diabetes. The method of the course of purulent wounds prognoses based on immunocytochemical identification of the expression of the proapoptotic protein p53 and the protein Ki-67- the proliferation marker has been substantiated.