Complications and side effects of neoadjuvant polychemotherapy of the patients with cancer of larynx
The purpose of the work was to analyze the complications and side effects of neoadjuvant polychemotherapy at pa- tients with cancer of larynx with different types of introduction of preparations and estimation of possibility of their pro- phylaxis. The combined and complex treatment was conducted at 296 patients with epidermoid cancer of larynx with the use of neoadjuvant polychemotherapy, which got the combined and complex treatment. Polychemotherapy conduct- ed on three charts: 1) PBMF, 2) TP (Paklitaxel - Mitotax), 3) TP (Docetaxel). Complications before and after poly- chemotherapy were classified by criteria of estimation of side effects of therapy CARTFUL. Analysis of the general state of the patients, complications and side effects of hematological, nonhematological; general and local toxic; and related to the selective cannulation were conducted. The most toxic effect which is expressed in worsening of the general state registered in the group of the patients which got polychemotherapy on the chart of PBMF - only at 53 (35,3%) patients general state did not suffer. The indexes of toxicity were higher in the group of PBMF patients, Flu-syndrome and alo- pecia most often was established in this group that was observed at more than 75% patients. Analysis of complications of polychemotherapy at patients with cancer of larynx showed decreasing of frequency and degree of disorders of compli- cations in the group of patients which got polychemotherapy on the basis of taxan at high efficiency of the treatment.