Anti-inflammatory effect of domestic medicinal preparation VIFERON® in chronic papillomavirus infection of pregnant women according morphometry of placenta
The study of the effect of domestic medicinal preparation VIFERON®, rectal suppositories (recombinant human interferon alpha-2b with antioxidants vitamins C and E), on the structure of the placenta in pregnant women with chronic papillomavirus infection. Thirty placentas were collected in two groups of women, comparable in clinical symptoms as well as in 100% PCR-detection of papillomavirus type 16 and 18 in cervix-gastric wash. Five to six samples of placental tissue were submitted to a routine histological procedure. Paraffin sections were subjected to hematoxylin and eosin staining. The degree of 10 pathological and compensatory reactions including chronic placental insufficiency was evaluated on a three-point scale. The differences were tested by Mann-Whitney U test. In the untreated group of women, placenta exhibited inflammatory changes according to the hematogenous type of infection of papillomavirus (intervillusites, subchorionites, deciduites), retardation of certain groups of villi and haemorheological disorders. Moderate chronic placental insufficiency and slight decreased baby weight were diagnosed in 83.3% of the cases. Cycle of treatment with VIFERON® suppositories in the 1st and 2nd trimesters of pregnancy induced significant reduction of inflammation, intervillar hemorrhages, immature villi and, most importantly, chronic placental insufficiency (26,6%) due to the activation of compensatory angiomatosis. As a result, the weight of newborns reached the norm. We obtained morphometric evidence of the efficacy of VIFERON®, in early treatment of placental insufficiency of the viral nature.