MONITORING OF SOME PHYSIOLOGICAL AND BIOCHEMICAL PARAMETERS OF BLOOD OF DIFFERENT AGED DOGS AND CATS IN A STUDY OF TOLERANCE OF THE INSECTOACARICIDE COLLAR "NEOTERICA PROTECTO 12"
The study results of tolerance of complex insectoacaricide preparation for veterinary use "Neoteric Protecto 12" (imidacloprid, pyriproxifen and ethofenprox) on target species of animals - dogs and cats - are presented. To examine the safety of the preparation the study included 1-3 years dogs and cats, including puppies and kittens of 3-5 months of age. 3 groups were created - control and 2 experimental respectively. Animals of the first experimental group wore a single collar of appropriate length (therapeutic dose). Animals of the second experimental group wore 3 collars of appropriate length (threefold increased therapeutic dose). Control animals were not given the preparation. Dogs, cats, puppies and kittens of the experimental groups wore the collars for 6 months. As a result of tolerance study of daily observed animals during the experimental period it was found that the general state of all groups of dogs, puppies, cats and kittens did not change significantly: all the animals were in a satisfactory condition, were mobile, active, willingly took food and drank water, there were no abnormalities of physiological functions, no any toxic phenomenon, conditioned reflexes were retained. The preparation "Neoteric Protecto 12" which is used in therapeutic and in threefold increased therapeutic doses, has no negative effect on physiological status of pets of different age groups. The studies have shown a good tolerance of the preparation. The significance of this study is that the effect of therapeutic and threefold increased therapeutic doses are studied to the body of those animals on whom the use of the preparation in veterinary practice is focused.