Features of Clinical Management of Women with Intrauterine Infection of the Fetus on the Background of Cervical Pathology
Objective. The evaluate the efficacy and safety of genferon use in combination treatment of intrauterine infection of the fetus secondary to cervical pathology compared with standard therapy. Materials and Methods. The study involved 60 women with intrauterine infection of the fetus on the background of cervical pathology. 34 patients received wilprafen, polygynax in combination with genferon rectally; 26 patients used wilprafen and polygynax. Evaluation of treatment efficacy was conducted on clinical findings, laboratory and instrumental methods. Results. The use of fixed combination genferon in the complex treatment of pregnant women with intrauterine infection of the fetus and cervical pathology made it possible to reduce the incidence of obstetric and neonatal complications (incidence of low birth weight — 3-fold, uterine birth activity anomalies — 4-fold, occurrence of premature labor — 5-fold), to normalize lower genital tract biocenosis. Conclusions. Genferon in the complex treatment of pregnant women with intrauterine infection of the fetus on the background of cervical pathology enhances the effectiveness of antimicrobial therapy, and reduce the incidence and severity of gestational complications.