Shipping and subchronic toxicity of a preparation Tsiproventor on calfs
As a result of carrying out 2 experiments it is established that Tsiproventor set by an animal in therapeutic (0,4g/10 kg) and it is triple increased (1,2g/10 the kg) doses significantly doesn't influence physiological indicators of blood and urine as when studying shipping, and subchronic toxicity. Under the influence of the drug Tsiproventor entered in a threefold increase in dose (Experiment №1), erythrocyte calves experimental groups at the end of experimentation was to 2,62-3,4% higher than in the control group. In the experimental groups the amount of hemoglobin also increased compared with the control group - on 7,34-19,4%, reflecting the positive effect of the drug on the morphological parameters of blood. It is found that none of the applied doses, given for 30 days, no adverse effects on the organism of animals. The clinical condition of the animals throughout the experiment, as well as in the end it did not differ from the control animals. Fluctuations in the quantity of erythrocytes and leucocytes in 1 ml of blood, and the hemoglobin content in leuco cyte calves first and second experimental groups during the study period were normal and did not differ significantly from that of control animals. Urine specific gravity and pH of urine in laboratory animals have not changed after administration Tsiproventor. Thus, the study of morphological and biochemical indices of the blood of calves experimental groups after treatment Tsiproventor evidence of its good tolerability and expressed its biological effect on the animal organism.