Effect of various oxygen concentrations applied at multicomponent endotracheal anesthesia on the parameters of venous blood gas composition
Objectives. To investigate the effect of oxygen various concentrations applied at multicomponent endotracheal anesthesia on the basis of sevoflurane on the parameters of venous blood gas composition and the acid-basic state. Methods. 67 persons (12 men and 55 women) at the age from 18 till 80 years who were being operated routinely were included in a prospective, randomized controlled trial. Patients were divided into two groups depending on the applied intraoperative concentration of oxygen in the inhaled mixture with FiO2 50%and 35%. The acidbasic state and venous blood gas composition at three stages (prior to the beginning of operation, during it and after anesthesia) were investigated. Results. Application of high oxygen concentration during anesthesia results in substantial growth of oxygen pressure and an oxygen saturation in the venous blood. At using during anesthesia of FiO2=35%, oxygen pressure was 78,6±27,1mmHg, and the saturation was 92,8±7,9%. It testifies to the fact that at multicomponent balanced anesthesia with sevoflurane, patients without lung diseases have raised oxygen content in the venous blood. Reduction of the previously increased lactate level in the venous blood (1,3±0,3 mmol/l in comparison with 2,9±0,9mmol/l at 1 stage (ð <0,001)) during anesthesia also testifies to the sufficient body oxygenation. Conclusions. Application in patients during endotracheal anesthesia of the oxygen concentration which when inhaled is equal to 35% results in oxygen pressure increase in the venous blood as well as in lactate level decrease testifying to the adequate oxygen supply to the organism tissues.