Dynamics of Serum Concentration of Pro-Inflammatory Cytokines during the Treatment of Sharp postoperative Pancreatitis in Oncological Patients
The study illustrates changes in dynamics of pro-inflammatory cytokines concentration at various ways of prophylaxis and treatment of acute postoperative pancreatitis after splenectomy in oncologic patients. Pro-inflammatory cytokines - IL-1, TNF-α, IL-6 and IL-8 - are among main mediators of acute inflammation phase, and increase of their production may be evidence of inflammatory process development. 44 patients underwent surgical treatment that included splenectomy as the main or complementary component of surgical treatment. The patients were divided into 2 groups - the study group (20 patients) and the control group (24 patients). Taking into account the high risk of acute postoperative pancreatitis development, extracorporal pharmacotherapy with gordox was included into treatment complex (the study group), against standart method of gordox administration (the control group). Analysis of the results showed favourable dynamics in changes of concentration of pro-inflammatory cytokines under study due to more manifested tendency to decrease during the whole postoperative period in patients receiving extracorporal pharmacotherapy with gordox, in comparison with patients receiving gordox by standart method.