Study of the Biological Effect of Dinitrosyl Iron Complexes with Glutathione during Nitric Oxide Overproduction, Induced by Endotoxin Shock
The objective of the present work is to study the biological effect of dinitrosyl iron complexes with glutathione ligand as a stabilized form of nitric oxide in a rat model of nitric oxide overproduction induced by inflammatory stimuli. We have shown that after injection of dinitrosyl iron complexes with glutathione ligand during endotoxin shock total nitric oxide level in rat organs remains unchanged. Dinitrosyl iron complexes with glutathione ligand exert a protective effect; they induce suppression of nitric oxide overproduction in liver tissues and accumulate with protein ligands in mammalian kidney.