The Basic Biochemical Aspects of the Pathogenesis of Depression Part 1
The review highlights the close relationship between hormones, cytokines, neurotransmitters, acting as primary messengers and reactive oxygen species, perceiving their signal and act as second messengers in the regulation of functional activity of cells. The close relationship between the functioning of primary, secondary and tertiary receptors enables inclusion adaptation mechanisms in the stress impacts. Violation organism's adaptation system underlies many pathological conditions including depressive. Given the diiculty in diagnosis of depression in psychiatry, low efficiency of therapy of antidepressants in the background of a large number of side effects, it is a topical coverage of issues related pathomorphism depression. We have presented the literary and own data on the role of oxidative stress as one of the pathogenetic links a depressive disorder, on its close relationship with the immune response of the body, сentra1 and peripheral inflammation, as the endocrine system, apoptosis and neurodegeneration, neuronal damage and decrease of neurogenesis, reflecting the putative cellular mechanisms of development of depression.