FEATURES OF THE IMMUNOLOGICAL STATUS OF FREQUENTLY ACCIDENT GIRLS-TEENAGERS
Objective: to assess the immunological status of frequently and longterm accident teenage girls based on the study of immunity indicators. Materials and methods. Clinical and immunological features were studied retrospectively in 42 often and longterm accident teenage girls with chronic upper respiratory tract pathology. Assessment of immunological status was carried out on the basis of a comprehensive study of indicators of cellular (absolute and relative content in peripheral blood of Tlymphocytes) and humoral (relative and absolute content in peripheral blood of Blymphocytes, serum immunoglobulins A, M, G) immunity. Results. Divergence of changes in the Tcellular link of immunity is established at it is frequent and long accident teenage girls: reduction of maintenance of CD3+ of cells substantially was followed statistically not by reliable decrease in absolute number CD4+ of cells (p>0,05). Besides doubtful decrease in absolute number CD8+ of cells (lymphocytes) is noted that can promote prevalence of the stimulating influence of CD4+ of cells including on Blymphocytes. CD16+lymphocytes (NK cells), cells - the effectors responsible and for virusinduced immunity, was increased in comparison with an indicator at incidentally ill teenage girls (p<0,05). It is caused by replaceable action of CD16+ of cells in the conditions of more expressed decrease of the activity of a suppressor link. Increase in the index of immunoregulation should be regarded as a condition of hyperactivity. At it is frequent and long the ill teenage girls low levels of serumal IgA, IgM (1,18±0,09 and 0,95±0,03 g/l respectively) against the background of increase in maintenance of IgE by 3,2 times were observed (p<0,05). The IgG level remained within physiological level that it is possible to explain with transition of IgG from blood serum in secretion of airways in connection with a hyperpermeability of membrane structures at inflammatory process. Conclusions. The presented data on the presence of immune imbalance in often and longterm accident teenage girls confirm not only the relevance of the studies, but also the need for immunocorrection. The development of a prophylactic immunocorrection program should be pathogenetically justified and have significant advantages over modern standard methods.