Influence of preventive administration of oligomeric proanthocyanidins on lipid metabolism and antiradical activity in liver of ratsin carbon tetrachloride poisoning
It was shown that in carbon tetrachloride (CT) poisoning in liver and blood plasma of rats is registered the impairment of antiradical activity, main membrane structural and metabolically active phospholipids fractions, accumulation of triglycerides, free fatty acids, lysophospholipids. The lipids peroxidation is activated. Preventive administration of oligomeric proanthocyanidins before and in the period of poisoning with CT, reduces the free radical reactions level in liver and blood of laboratory animals and preserves the lipid metabolism parameters. Effectiveness of preventive administration of oligomeric proanthocyanidins in CT poisoning exceeds the reference hepatoportector “Legalon”.