The state of immune system in patients with irritable bowel syndrome
There were examined 46 patients with IBS and 20 practically healthy persons. Immunological examination included determination of the number and subpopulation composition of lymphocytes (CD3, CD4, CD8, CD16, CD19), the CIC level, immunoglobulins G, M, A, IgG4 and IgE, and TNF-α in blood serum. The studies showed that the absolute number of lymphocytes was reduced in IBS patients, which led to the change in the subpopulation composition. It affected, first of all, the T-link of immunity. Increase of the content of humoral factors in blood serum was noted. The examined patients have a high level of IgM, IgE and IgG4, CIC and TNF-α, which confirms the presence of inflammatory and/or allergic component in IBS.