THE IMPORTANCE OF AUTOANTIBODIES TO PLACENTAL PROTEINS FOR THE DIAGNOSIS OF FETO-PLACENTAL INSUFFICIENCY
In the serum of 74 women with physiological pregnancy and 41 women with pregnancy complicated by placental insufficiency (FPI), divided into subgroups by severity of placental insufficiency (PI), and fetal growth retardation (IUGR) I and II degree in terms of 10-14, 20-22, 30-32, 39-41 weeks of gestation by counter immunoelectrophoresis (CIEF) searched antibodies to placental proteins. Three types of anti-placental autoantibodies (AAB): against specific for placental membrane protein PLAP (anti PLAP AAT), against interorganic tissue placental protein ferritin (antiFrt AAT) and against pool of soluble placental proteins of alpha-globulin nature (antiAGP AAT) were investigated. In the sera of 1,5-2,9% of parous women-donors founded autoantibodies to all placental proteins. Single cases of detection antiFrt AAT in the blood of donors and pregnant women indicate about non-gestational reasons for their formation. The frequency of detection antiAGP AAT in physiological and pathological pregnancy increases during gestation. First established fact of the appearance of autoantibodies anti PLAP proportional to the severity of the FPI. For preclinical estimation of pregnancy complicated by FPI is recommended to determine antiPLAP autoantibodies by CIEF-test beginning with period 20-22 weeks of gestation.