Pathobiochemical peculiarities of brain in critical states of organism and ground of metabotropic therapy. Part IІ. Pathophysiology of brain at critical states and its pathobiochemistry
Description of pathobiochemical processes of the brain in conditions of its predominating injury in the critical state oforganism is presented. The analysis of possible direction and transitory moments from the biochemical processes of cer- ebrum activity in physiological conditions to forming of proper pathobiochemical transformations was conducted.Attention was fixed on metabolic reflection of decline of regulator role of cerebral insulin and possible manifestations of activity of contrinsulin mediatory-hormonal complex and aggregation of proinflammatory factors is fixed. The role of hyperglycemia as one of the leading pathogenic component as well as progressive brain hypoxia and intracellular aci- dosis is shown. The attempt of analysis of misbalance in the metabolic system of the brain for the ground of pharmaco- logical aspects of metabotropic therapy was made.