PDCD4 regulatory protein in tissue gastric mucosa in chronic gastritis and stomach cancer
The article presents the results of an immunohistochemical evaluation of PDCD4 protein in patients with intestinal-type gastric cancer to determine the prospects for using it as a molecular marker of prediction and early diagnosis of gastric cancer. Samples of gastric cancer surgical material (intestinal adenocarcinoma tissue and fragments of the gastric mucosa of the distant zone with chronic gastritis) from 45 patients were studied. An immunohistochemical study revealed a statistically significant decrease in the level of PDCD4 in tumor cells of gastric cancer of the intestinal type, mainly due to the loss of the nuclear fraction, compared with the mucous membrane of the distant zone of the gastric cancer with a histological picture of chronic gastritis. The obtained results allow us to consider the PDCD4 protein as a potential additional immunohistochemical marker for the early diagnosis of gastrointestinal cancer