Influence of oxidative stress on the transport of bioelements in the small intestine of rats
The article studies the features of transport of biogenic cations in the small intestine of rats under glucocorticoid-induced oxidative stress. The processes of ion transport through the gastrointestinal wall were investigated by in vivo perfusion of the small intestine. In perfusion samples, the content of Na, K, Ca, Mg, Fe, Zn, and Cu ions was determined by the method of atomic emission analysis with inductively coupled plasma. The state of the level of redox processes in the small intestine of rats was evaluated by the activity of superoxide dismutase and catalase, as well as the content of malondialdehyde and diene conjugates in tissue homogenates. It has been established that under glucocorticoid-induced oxidative stress in the small intestine, the transport of biogenic macro- and micronutrients is violated - a decrease in the absorption of macronutrients and the secretion of micronutrients. The use of the antioxidant "α-tocopherol" and the new-generation phenolic sulfur-containing antioxidant "Thiofan" in the experiment indicates the important role of free radical lipid peroxidation in the disruption of the transport of macro- and microelements in the small intestine. “Thiofan”, possessing a unique structure that provides intramolecular synergism, protects the membrane structures of cells and helps to correct the transport of bioelements in the small intestine.