CORRELATION OF THE PHYSIOLOGICAL CHANGES OF THE LEVEL OF HOMOCYSTEIN AND ITS BASIC METABOLITES WITH HORMONAL STATUS OF PREGNANT WOMEN WITHIN THE SECOND AND THIRD TRIMESTERS OF AN UNCOMPLICATED PREGNANCY
The purpose of our research was to study the physiological changes of the concentration of homocystein and its basic metabolites in women’s blood during the second half of an uncomplicated pregnancy as well as to estimate the character of correlation of these changes with the dynamics the shifts in the hormonal status in different terms of gestation. The article shows the correlation of the physiological changes of the level of homocystein and its basic metabolites with hormonal status of pregnant women within the second and third trimesters of an uncomplicated pregnancy. The study was carried on by the method of highly effective fluid chromatography with fluorescent detection, hormones being determined by radioimmune method. 72 women have been examined, 32 out of them were not pregnant and 40 had a physiological course of pregnancy with terms of 19 – 39 weeks. The concentration of homocystein and cystein in the physiological course of pregnancy is less as compared to that in intact non-pregnant women, the level of homocystein in blood serum in normal pregnancy correlates positively with the level of progesterone and negatively with the level of estriol.