ВПЛИВ АКТИВАТОРА АТФ-ЗАЛЕЖНИХ КАЛІЕВИХ КАНАЛІВ ФЛОКАЛІНУ НА КИСЛОТОРЕГУЛЮВАЛЬНУ ФУНКЦІЮ НИРОК ЗА УМОВ НАВАНТАЖЕННЯ 0,45% РОЗЧИНОМ ХЛОРИДУ НАТРІЮ
It has been stated that a single administration to white rats of potassium channels activator Flocalin under conditions of load with 0,45% solution of sodium chloride is followed by dose-dependent elevation of urinary excretion of free hydrogen ions, and administration of a dose 10 mg/kg results in increase of excretion of hydrogen ions as a component of ammonium compounds. On the 7th day of drug administration we observed a decrease of excretion of hydrogen ions of ammonium compounds, dose-dependent decrease of excretion of titrated acids and active hydrogen ions, increase of urine рН.