POST-TRANSPLANTATION CARDIOMYOPATHY: ENERGY-PRODUCING PARTICLE OF CARDIOMYOCYTES AT THE TERMS UP TO 25 YEARS OF ORTHOTOPIC HEART TRANSPLANTATION
Russian Scientific Center of Surgery named after B. V. Petrovsky has an experience of 30 orthotopic heart transplantations with the maximum follow-up 25 years. Nine patients survived 11-year period after operation, of those in 6 during long-term period of 11-25 years we studied ultrastructural assessment of cardiomyocytes of the donor heart. This article provides the results of mitochondrial particles: the data witnesses on the increase of destruction in mitochondria with time that finally leads to energy deficit of cardiomyocytes and progression of post-transplant cardiomyopathy.