THE EXPERIMENTAL MODEL OF TOXIC EDEMA OF LUNGS AT LABORATORY ANIMALS CAUSED BY INTOXICATIONPRODUCTS OF FLUOROPLASTICS
Nowadays, various polymeric materials are increasingly used. While burning, substances with a pulmonary toxic effect are released. For example, the products formed after thermal decomposition of fluoroplastics lead to acute lung damage during inhalation exposure. In the experimental study, a model of toxic pulmonary edema in laboratory animals was created by means of the intoxication with fluoroplastics pyrolysis products. The effect of pyrolysis products after 30 minutes of exposure led to morphological and histological changes in lung tissue, an increase (p <0.05) in the pulmonary coefficient (18.3) in 24 hours after intoxication. An analysis of bronchoalveolar lavage fluid revealed an increase (p <0.05) in the total cell content due to an increase in the number of alveolar macrophages and neutrophils. The developed experimental model of acute lung damage in laboratory animals after intoxication with fluoroplastics pyrolysis products can be used to study the pathogenesis and search for pharmacological agents in this pathological condition.