P53 AND BCL2 EXPRESSION IN DIFFERENT BREAST CANCER SUBTYPES
р53 and bcl-2 expression in the breast cancer among the 95 patients with different molecular subtypes were analyzed. It was found, that the р53overexpression level among luminal B and Her2neu+ breast cancer subtypes was equal but few decreased among TNBC. The р53 concentration in luminal A subtype was in 2 times more rarely than in TNBC, and in 2,5 and in 2,7 times than in luminal B and Her2neu+, correspondingly. At the same time, the levels of the nuclear reaction with р53 antibodies in the tumor tissue and the quantity of the colored cells differed. The research of bcl-2 expression discovered its decrease of the positive cases according to the tumor receptor state changes, especially in TNBC and HER2neu+, which was several times lower. The least correlation (0,25) of the р53 expression to bcl-2 expression positive cases was found in luminal A subtype. Few higher this index was in TNBC and luminal B subtypes, 0,6 and 0,83, correspondingly. Inverse dependence was observed in HER2neu+ breast cancer, where the index was 2 and the prevalence of the p53 expression positive tumors above bcl-2+ was detected.