BIOPHARMACEUTICAL JUSTIFICATION OF COMBISEPT OINTMENT COMPOSITION AND TECHNOLOGY
The article is devoted to biopharmaceutical justification of composition and technology of Combisept ointment indicated for treatment of pyoinflammatory diseases and evaluation of its antimicrobial activity in comparison with reference medicinal agent. The article represents experimental data received during studies on release of active pharmaceutical ingredients (Benzalkonium Chloride, Laevomycetin, and Dexpanthenol) from various ointment bases; the choice of ointment base is based on the received data. Combisept ointment technology is presented. Study results of the ointment antimicrobial activity compared to the reference medicinal agent are given.