PREDICTORS OF SECONDARY RESISTANCE TO ACETYLSALICYLIC ACID AT PATIENTS WITH ISCHEMIC HEART DISEASE OF ELDERLY AGE
Article is devoted to development of secondary resistance to acetylsalicylic acid that has particular clinical importance and serious danger for patients needing regular antiaggregant therapy. The retrospective analysis of patient’s anamnesis with developed syndrome of aspirin resistance was carried out; risk factors that have the greatest influence on the development of this phenomenon were identified. Predictors of secondary aspirin resistance development were described: high (more than 7,0 mmol/l) cholesterol plasma level; diabetes mellitus — glucose level above 8,5 mmol/l both in patients with diabetes anamnesis and in other persons with newly detected hyperglycemia; left ventricular ejection fraction — less than 55%; smoking more than 10 cigarettes a day; disturbed blood flow in microvessels — microcirculation index less than 1,1 ml/min; level of endothelium-dependent vasodilation less than 4,0 ml/min/100 g.