THE ROLE OF NITROGEN OXIDE IN THE DEVELOPMENT OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH PSEUDOEXFOLIATIVE GLAUCOMA
The objective of the research was to study the content of nitrogen oxide stable metabolite - nitrogen nitrite (NO ¯) - in blood serum and in lacrimal liquor of patients with pseudoexfoliative glaucoma (PEG) depending on the stage and duration of the disease.¯) was determined in serum and lacrimal liquor. NO ¯ levels in serum and lacrimal liquor were lower than inNitrogen nitrite (NO22¯ was registered among the patients with the initial stage of pseudoexfoliative glaucoma, andnormal eyes. The high level of NO2minimum was recorded among the patients with advanced and terminal stages of the disease.22The estimation of the NO ¯ among the sick affected by PEG with various duration periods of the disease showed that the minimum concentration of NO ¯ is registered among the patients with the PEG anamnesis more than 10 years. There was a linear associ-2ation between the count of NO ¯ in serum and lacrimal liquor. The obtained data reflect the pathogenetic role of the functional status of the vascular endothelium in the formation of the endothelial dysfunction contributing to the progression of PEG.