Acute necrotizing encephalopathy: clinical observations in small infants
The leading etiological role in the genesis of viral encephalites in children belongs to the family of herpes viruses known for their neurotropicity. Acute necrotizing encephalopathy refers to infection-mediated lesions of CNS. It is characterized by a severe course with polymorphic clinical symptoms and characteristic imaging findings. The pathogenesis of this nosological form is unclear, one of the leading etiologically significant agents is human herpes virus type 6 (HHV-6). The article presents 2 clinical cases of acute necrotizing encephalopathy associated with HHV-6 in small infants. Clinical imaging specificities of cases and the significance of premorbid background factors are discussed.