Microbiological evaluation of II and III generation quinolones in prevention and treatment of inflammatory complication in oral surgery
The effect of various concentrations of fluoroquinolones on representatives of anaerobic microbiota has been studied. Prioritized pathogen Prevotella Intermedia was chosen for this purpose. Antibacterial activity of fluoroquinolones (ciprofloxacin and levofloxacin) was evaluated in blood samples after 1 and 3 hours of cultivation in a bioreactor. It was found that the growth curve on media with added serum in the presence of ciprofloxacin after 3 hours was approximately 2 times lower than after 1 hour cultivation (OD 2.0-2.5), although no complete inhibition of growth of the bacterial population was observed. In the presence of levofloxacin after 3 hours cultivation, there was a complete absence of bacterial growth (same as after 1 h), there was a bactericidal effect. Conclusion. The results of automatic control of bacterial population growth in bioreactors showed that levofloxacin has a bactericidal effect after 1 and 3 hours of cultivation. Ciprofloxacin had a bacteriostatic effect at the same time of observation. The experimental results confirm the high bactericidal activity and the rapid achievement of the minimum inhibitory concentration (MIC) of levofloxacin already after 1 h after administration.