ZINC-DEPENDENT FACTORS IN REGULATION OF HAIR FOLLICLE CYCLE
The article deals with the participation of zinc-dependent factors in the regulation of hair follicle cycle. Shown that zinc-containing factors involved in the regulation of anagen are bazonuklin, matrix metalloproteinases, metallothionein. Apoptosis of hair follicle cells is regulated by families of Bcl 2 and IAP, which proteins (Bax and survivin) are zinc-dependent. It is hypothesized that the minerals imbalance, leading to changes in the concentration of zinc in the body may be a factor in the pathogenesis of alopecia areata. Need experimental confirmation of the influence of trace-element imbalances in the structural and functional condition of the hair follicle.