NEOPTERIN IN SEVERITY ASSESSING OF ATOPIC DERMATITIS IN CHILDREN
Clinical and immunological research, including determination of serum neopterin in children with atopic dermatitis (AD). The study group included 39 children aged 2 to 6 years of age (mean age 3,42 ± 1,75) with atopic dermatitis of varying severity established by the totality of clinical data, taking into account the index SCORAD and EASI. The control group consisted of healthy children. Correlation between the degree of severity of atopic dermatitis and neopterin levels in serum: with increasing severity of the disease and marked increase in the concentration of serum neopterin in patients with AD. It was found that serum mild blood children with atopic dermatitis severity at admission neopterin concentrations ranged from 2.6 ng / mL to 4.0 ng / ml, in patients with moderate severity of AD neopterin concentration had a value of 4.1 ng / ml to 5.9 ng / ml, and in children with severe disease and continuously with relapsing – respectively 6.0 ng / ml or higher. The study showed that the determination of neopterin can be used as additional laboratory criterion degree of atopic dermatitis severity.