Effect of Erythrocyte Microvesicles on Spontaneous Aggregation of Platelets
The effect of red blood cell microvesicles isolated after 24 and 48 h incubation of red blood cells from healthy donors on the spontaneous (stress-induced) platelet aggregation and the final stage of blood coagulation were studied. It was found out that microvesicles of erythrocytes decreased spontaneous aggregation of platelets and slowed down thrombin time of blood plasma. Possible mechanisms of the antiagregation and anticoagulation effect of erythrocyte microvesicles was investigated.