The endothelial secretion of vasoactive molecules at the cold injury of extremities
The aim was to study the level of endothelin-1 and nitrites in blood of 60 men aged from 17 to 45 with the local frostbites of low extremities of II-IV degrees. The concentration of nitrites in blood in the different periods of the trauma was detected by P. Golikov's method [2]. Endothelin-1 wasdetected by ELIS A. Blood flow fluctuations were registered by the laser Doppler flowmetria method. It was determined, that in patients' blood the endothelin-1 level increases in 2,4-4,5, the concentration of nitrites decreases in 1,6-2,4. Thus, the nitrites/endothelin-1 ratio directly influences on the maximal amplitude of blood flow fluctuations in endothelial range (r=0,97, p<0,01).