TECHNOLOGY OF "PCG-1" AS THE BASIS FOR SOFT DRUGS
The work is devoted to the study of the development of technology for producing polycomplex gels based on sodium carboxymethylcellulose (Na-CMC) with urea formaldehyde oligomers (MFOs) as the basis for long-acting soft drugs. On the basis of experimental data, it has been established that the base obtained using Na-CMC and MFOs is easily applied to the skin and maintains its homogeneity and stability during long-term storage. Also, quality indicators were determined such as: color, smell, appearance, pH, aggregative stability during centrifugation and under the influence of temperature, as well as the shelf life of the base that meets all the requirements of regulatory and technical documentation. The proposed gel composition based on Na-CMC-MFO, in which, due to the optimal combination of components, the controlled molecular structure of the polymer complex as a result of the self-organization of macromolecules in the process of its formation, structures with adjustable sizes are formed. The possibility of using IPK gels based on Na-CMC-MFO as a basis for drug systems with targeted transport properties and controlled release of drugs has been shown. A technology has been developed for producing polycomplex gels based on Na-CMC and MFOs as the basis for long-acting soft drugs with optimal physicochemical, physicomechanical and performance characteristics. A flow chart for the production of polycomplex composites has been compiled and the main technological parameters have been established under production conditions.