Comparative characteristics antibiotic susceptibility of basic pathogens cause community - acquired respiratory tract infections in children in Ural Region 2005-2007
The purpose of this study is to find out diffusion frequency and development dynamics of the resistance to different antibiotics such strains as H. influenzae, S. pneumoniae, S. pyogenes, M. catarrhalis. These strains were isolated in children with respiratory tract infections on territory of Sverdlovsk region and Ekaterinburg 2005-2007. The antibioticograms of 161 non-typing H. influenzae strains, 71 S. pneumoniae strains, and 25 S. pyogenes strains were researched. Also penicillinase activity of 31 M. catarrhalis strains was checked. All strains were obtained from bronchoalveolar lavage, sputum, nose, and ear. As a result, H. influenzae has high susceptibility to β-lactam antibiotics. 3.7% β-lactamase-negative ampicillin-resistant and 1.9% β-lactamase-producing ampicillin-resistant were found. Also β-lactamase-negative ampicillin-intermediate strains were detected (0.6%). A small increase of S. pneumoniae resistance to penicillin and other β-lactam was observed. 33.9% S. pneumoniae strains were resistant to trimethoprim/sulfamethoxazole. All β-lactam antibiotics were active against S. pyogenes. 45.2% β-lactamase-producing M. catarrhalis strains were found.