Peculiarities of left ventricle myocardium re-modeling in women with arterial hypertension, metabolic syndrome and hypothyroidism
Combination of arterial hypertension (AH), metabolic syndrome and hypothyroidism is frequently seen in women. Influence of these pathologies on re-modeling and diastolic function of left ventricle is not well studied. Objective: to evaluate structural and functional changes in left ventricle myocardium in women with AH, metabolic syndrome and hypothyroidism. Methods: 119 women were included in the study: 90 patients with AH, metabolic syndrome and hypothyroidism and 29 healthy women as a control. Main criteria of re-modeling and diastolic function of left ventricle were estimated with echocardiography. Results: patients with clinically significant hypothyroidism frequently had AH stage III compared to those with subclinical hypothyroidism and healthy women. Left ventricle hypertrophy was revealed in 71 (79%) of women with hypothyroidism and in 10 (34%) patients with normal function of thyroid gland (р < 0.05). Concentric hypertrophy was detected in 23 (49%) women with clinically significant hypothyroidism, in 15 (35%) women with subclinical hypothyroidism and in 4 (14%) patients from control group. Rigid type of diastolic dysfunction of left ventricle myocardium was registered in 38 (81%), 34 (79%) and 23 (79%) of patients correspondingly. Conclusion: pathological types of left ventricle frequently develop in patients with AH, metabolic syndrome and hypothyroidism compared to women with normal function of thyroid gland. Diastolic dysfunction develops independently of the presence or absence of hypothyroidism.