MULTIVARIATE STUDY OF RISK FACTORS FOR THE FETUS CHROMOSOME PATHOLOGY
Aim: the discovery additional medico-social signs for woman with the high risk of the fetus chromosome pathology in first trimester of pregnancy. Material and Subjects: the object of a continuous prospective study were 78 pregnant women of Tula region, who were observed in the medical genetic department of the Tula regional perinatal center in 2013-2014 yy. and had a high risk of the chromosome syndromes development (Down, Patau, Edwards) from 11 to 14 weeks of pregnancy. The lifestyle woman's parameters were studied with special questionnaire with where included different aspects of the work, relations in family, rest, medical activity, bad habits. Data about health condition was received by method of the full anamnesis collection and copied from primary medical documentation. Results: women with increased risk of chromosome pathology were belonging to older age group (47,4% was older 35 years), residence in town (65,4% of women), a high level of education (50,0% had higher education). Increasing of the fetus neck region thickness more than 2,5 mm was revealed for 19,2% women's, absence or nasal bone hypoplasia - for 43,1% pregnants. The PAPP-A reduction less 0,5 MOM was fixed in 13,9% cases and excess of the sign more than 2,0 MOM - amongst 19,4% females (similar changes b-HCG were installed for 16,7% and 4,2% woman's accordingly). The high risk of Down syndrome was exposed for 8,3% women's, Patau syndrome - 9,7% and Edwards syndrome - 47,2% patients. The multivariate methods of the study have allowed to define the additional medico-social signs associated with risk of fetus chromosome pathology: level of the mental tension in professional activity, non-observance of the feeding mode, presence of ureaplasma, vagina candidosis in anamnesis and catarrhal diseases of lungs during pregnancy. Conclusion: the calculation of the risk for most frequent fetus chromosome syndromes during prenatal diagnostics in first trimester of pregnancy can be greatly improved by revealing factors, based on the interaction of some effective medico-social signs.