AN INFLUENCE OF PERSISTENT HERPES VIRAL INFECTION ON THE COURSE OF MULTIPLE SCLEROSIS
It was performed an analysis of medical documentation of 207 patients with multiple (MS) hospitalized in clinic of Rostov Medical University from 2006 up to 2014 years to reveal the prevalence of persistent herpes viral infection (PHVI) and also to evaluate a probable features of disease course. The main group was comprised of 47 MS patients with PHVI, the control group was comprised of 160 MS patients without comorbid pathology. It was evaluated a type of MS course, clinical features, EDSS, the specificity of MS progressing. PHVI was diagnosed according to the investigation of antibodies against herpes viruses of different groups during the relapse of multiple sclerosis by enzyme-linked immunosorbent assay (ELISA), also it was investigated the avidity index. The PHVI was revealed in 22,7 % of MS patients. The prevalent pathogens of PHVI were Epstein - Barr virus (EBV) and cytomegalovirus (CMV). There were observed predictors of unfavorable course of MS: significant pyramid and cerebellar disorders, a low duration of the first remission, a high MS progression speed, an early occurrence of secondary-progressive course. The phenotype of multiple sclerosis (MS and PHVI) nowadays is of a great interest as from theoretical, as from practical opinions.