HEPATIC INSUFFICIENCY CORRECTION IN COMBINED THERAPY FOR INFECTED PANCREATONECROSIS
The purpose of this research was to study the frequency rate of acute hepatic insufficiency in patients with infected pancreatonecrosis and to define methods of its correction. The study material included 118 patients with destructive pancreatitis divided into 3 groups: the 1st group was comprised by 69 patients presented no symptoms of acute hepatic insufficiency\impairment, the rest of them were referred to as having severe clinical presentations of acute hepatic insufficiency. Besides, 25 of 118 patients (the 2nd group) underwent medicinal\drug treatmen for liver dysfunction while 24 of 118 (the 3d group) did not. The trial has shown the combination of hepatic insufficiency with infected pancreatonecrosis to be associated with a high rate (71,4%) of lethality, whereas in infected pancreatonecrosis without the above concurrent condition (the 1st group) the lethality rate is barely 18,8%. Hepatic insufficiency correction with heptral and mexidole results in decrease in lethality rate from 87,5% (3d group) down to 56% (2nd group), statistically significant (р<0,05) decrease in plasma cytolysis, cholestasis and procalcitonin indeces.