Assessment of the impact of pharmacological preconditioning with recombinant erythropoietin on the state of the resected liver in experiment
The effect of pharmacological preconditioning with recombinant erythropoietin in sub-erythrostimulating dose on the state of the resected liver in white Wistar rats is studied. 70% liver resection was performed on the second day of the experiment. Recombinant erythropoietin was administered intraperitoneally at a daily dose of 2.5 IU/kg during the first 7 days of the experiment, every 48 hours. We found that pharmacological preconditioning with recombinant erythropoietin has a pronounced stimulating effect on the regeneration of the resected liver, as evidenced by reducing the mortality of post-resection liver failure, a significant reduction in the severity of symptoms of post-resection liver failure compared with the control group; recovery of volume, structure and functions of the resected organ until 28 days after resection, which was not observed in the control group.