Heterogeneity of cytokines in immunopathogenesis of ulcers of duodenal gut, in erosion and chronic gastritis, associated with hereditary abnormalities of connecting tissue
Results of interrelation cytokines dysfunctions in immunopathogenesis ulcers of duodenal gut and chronic erosion gastritis at young men, immunopathogenesis which abnormalities with hereditary infringements of connecting tissue with various degree of expressiveness are presented. It is established that the leading part in development of an inefficient immune inflammation in studied variants of pathology belongs immune inflammathion to the processes accompanying hereditary infringements of connecting tissue, instead of contaminathion H. pylori. Degree of expressiveness hereditary infringements of connecting tissue is a major factor and in occurrence аtrophy changes of a mucous membrane of a stomach that was accompanied mainly monocytes infiltrations in a mucous membrane. Development of the sharp period both ulcers of duodenal gut and chronic erosion gastritis was accompanied by increase of concentration proinflammathory cytokines which decreased in the remission period. However expressiveness of this dynamics in groups essentially differed. So, at ulcers of duodenal gut in the period of aggravation of profiles proinflammathory cytokines (interleukin -1β, 6, 8, tumor necrosis factor-alpha, interferon-gamma) were much above in group with expressed semiology of hereditary infringements of connecting tissue in comparison with indicators of group with moderate semiology. In group of the patients suffering from chronic erosion gastritis, quantity indicators proinflammathory cytokines at persons with expressed semiology of hereditary infringements of connecting tissue were close to the data of the patients, suffering from stomach ulcer only on interferon-gamma profiles. Expressed contamination H. рylori promoted increase in concentration interleukin -8 in all groups. Cytokines it is necessary to carry substantial growth of concentration IL-6 and absence of significant increase of concentration tumor necrosis factor-alpha to features of investigated profiles at patients with hereditary infringements of connecting tissue in group of the patients suffering chronic erosion gastritis in comparison with indicators of patients with ulcers of duodenal gut. On the basis of profiles cytokines it is established that the tendency of development of immuno-inflammatory process at the patients suffering from ulcers of duodenal gut is connected, mainly with the activity of effector cells Th-1 of type, and at patients with chronic and erosion gastritis's - Th-2 of type. The revealed changes of an immune homeostasis testify to the generated infringements in structure regulate and effectors links immunological reactance.