RENAL REPLACEMENT THERAPY OF SEPTIC CARDIAC SURGERY PATIENTS
Incidence of sepsis is 0,38 — 3,0 per 1000 population. If acute kidney injury (AKI) develops in septic patients (pts) mortality rises to 70-80% and exceeds that in AKI pts without sepsis. This is an analysis of subgroup of 25 cardiac-surgery pts with sepsis and AKI who need renal replacement therapy (RRT). 9 pts was treated with intermittent hemodialysis (IHD) and 16 pts — with continuous veno-venous hemofiltration (CVVH). There was no statistical difference between hospital mortality (HM) all of pts and prognostic value of HM (36% vs 46,3%, respectively, р=0,304). HM of CVVH treated pts was statistically significantly lower in comparison to IHD treated pts (6 (66,7%) vs 2 (18,8%), respectively, р =0,019) and prognostic HM (18,8% vs 42,4%, respectively, р=0,033). There no statistical significance in difference in outcome among survived pts at discharge. Parameters correlated with HM in bivariant correlation were included in Cox regression. Hazard ratio for HM was 2 for each 1 ml/kg/h rise in ultrafiltration rate (р=0,041) and 1, 034for each year in patient age (р=0,034). CVVH can reduce HM in comparison with IHD. Risk of death increased with increase of ultrafiltration rate and age of patient.