PECULIARITIES OF A CLINICAL COURSE AND AUTONOMIC REGULATION OF SINUS RHYTHM IN INDIVIDUALS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA
Connective tissue dysplasia (CTD), especially the undifferentiated form, is common among young people. External signs of connective tissue dysplasia and minor malformations are associated with somatic diseases, psychological disorders and autonomic disfunction. The aim of the study was to identify phenotypic, clinical, psychological manifestations and features of autonomic regulation in young people with undifferentiated connective tissue dysplasia (UCTD). Methods. We examined 67 young people aged 18-25 years. Clinical signs and symptoms of CTD were evaluated using standard methods. Pain intensity was measured by visual analog pain scale. Autonomic disorders were assessed using the Vein Questionnaire. The Hospital Anxiety and Depression Scale (HADS) was used to assess anxiety and depression. The autonomic regulation was evaluated by heart rate variability (method of high resolution rythmocardiography). All patients underwent a Multilateral Study of Personality on the basis of Minnesota Multiphasic Personality Inventory (MMPI) in modification of F.B. Berezin et al. All participants were divided into 2 groups. The UCTD group included persons with 6 or more external signs. The control group composed of participants who had less than 6 signs of CTD. Results. The syndrome of undifferentiated connective tissue dysplasia (UCTD) was identified in 64.2% (43 participants). We found that young people (regardless of the presence of undifferentiated connective tissue dysplasia) more frequently had head pain. Arthralgia was significantly more common in patients with the UCTD syndrome. The psychological manifestations identified by the multilateral study of personality in participants with UCTD characterized by fewer scores on the scale of social introversion. The features of autonomic regulation of heart rate variability were found using the method of rhythmocardiography. The predominance of the parasympathetic regulation of sinus rhythm was reveled in young people with UCTD. Conclusion. Young people with multiple signs of CTD differ significantly from the control group respect to clinical symptoms and psychoemotional state, and they have features of autonomic regulation of the heart rhythm.