GENDER DIFFERENCES IN THE DYNAMICS OF SOMATIC PATHOLOGY IN ALCOHOLIC PATIENTS IN A WITHDRAWAL PERIOD
With the aim to study gender differences in the dynamics of somatic pathology we assessed the contents of lipid peroxides, antioxidant defense factors (ascorbic acid, protein sulfhydril groups, vitamin E) and organospecific enzyme activity in the blood plasma of alcoholic patients in the I-II and II stages of the disease (83 men and 32 women). Our findings show that alcohol-induced liver injury in men and women is manifested differently. Hepatocyte destruction in women occurs mainly due to alcoholic hepatitis, and in men additional factors of the liver injury play a significant role. Alcoholic myocardium destruction is more expressed in women than in men. Besides, it was discovered that the peroxidation of lipids plays a leading role in the pathogenesis of alcoholic cardiomyopathy.