Epithelial-mesenchymal transformation as a prognostic criterion for renal cell carcinoma
Surgical material has been studied in 47 patients after nephrectomy with tracking lifetime and morphological evaluation of tumors using immunohistochemical methods in two groups: of short-term survival (STS) (3±6 months) and long-term survival (LTS) (more than 1.5±2 years). It is found that tumors in these groups differed by incidence of spindle cell epithelial-mesenchymal transformation: in STS group it was 96.4 %, in LTS group ² 42.1 %; as well as Furhman’s nuclear atypia: high in STS group (3rd±4th degree) met in 100 % of cases, in LTS group ² in 68.4 %. Incidence of spindle cell epithelial-mesenchymal transformation in renal cancer may be more sensitive prognostic factor than the degree of Furhman’s nuclear atypia.