Association analysis of APOB-100, LRPAP1, ABCG5 and ABCG8 genes polymorphisms in gallstone disease among patients from Bashkortostan Republic
Gallstone disease (GSD) - metabolic disease of the biliary system, characterized by the formation of stones in the gallbladder lumen and biliary tract. This is one of common pathology of the gastrointestinal tract. The association analysis of four polymorphisms of the APOB-100 (rs693), LRPAP1 (rs 11267919), ABCG5 (rs4131229), ABCG8 (rs11887534) genes in 195 patients with gallstone disease and 172 unrelated healthy individuals from Bashkortostan Republic was performed. The association analysis has revealed that *X- allele of rs693 of APOB-1O0 gene and *C allele of rs4131229 of ABCG5 gene are markers of increased risk of gallstone disease in Tatars. It was shown that the development of the clinical forms of chronic calculous cholecystitis is associate with *X+ allele and heterozygous genotype *X+X- of rs693 of APOB-100 gene, while development of acute calculous cholecystitis is associate with *C allele of rs4131229 of ABCG5 gene.