Study of Pathogenetic Mechanisms of Disorders of Cardiac-Pulmonary Hemodynamics in Extensive Lung Resection in the Experiment
This article presents the first experience of studying the characteristics of pulmonary hypertension and right heart failure with extensive lung resection, the feasibility of creation and study of reducing shunts in the experiment. The material of the pilot study consisted of 12 experimental Chinchilla rabbits. The study found that a one-time exclusion of significant amount of lung tissue from the bloodstream associated with significant impairments in hemodynamics and gas exchange. At the same time, extensive pulmonary resection with controlled arteriovenous shunt caused no significant hemodynamic changes, common normal conditions after resection of the appropriate size.