IDENTIFICATION OF HEMOSTATIC ACTIVITY OF MEDICINAL FORMS CONTAINING NANOCOMPONENTS
The effect of multicomponent pharmaceutical compositions presented in two dosage forms on changes in coagulogram indices was studied. The components of the compositions are represented by aminocaproic acid (fibrinolysis inhibitor), iron chloride (anti- anemic effect), sodium chloride (solution isotonation), iron nanoparticles (improved penetration into the lesion). The state of the hemostasis system was assessed by standardized methods that allowed us to characterize the main phases of the coagulation process: activated partial thromboplastin time, prothrombin time, thrombin time, fibrinogen content. The shortening of blood coagulation time was established under the influence of the developed compositions. The most pronounced hemostatic effect among the solutions was exhibited by sample No. 2 (3.0 g of ferric chloride, 4.0g of aminocaproic acid and 0.1 g of sodium chloride). The use of this sample contributed to the shortening of blood coagulation time relative to control studies in 1.7 - 2.0 times. The most pronounced hemostatic effect among soft dosage forms was exhibited by samples with a minimum concentration of nanocomponent (0.01%), and the type of nanocomponent does not exert a statistically significant effect on this effect.