DISTURBANCES OF STRUCTURAL AND FUNCTIONAL PARAMETERS OF THE HEART, METABOLIC FUNCTIONS OF THE LUNGS AND OXYGEN-TRANSPORT BLOOD FUNCTION IN PATIENTS WITH MYOCARDIAL INFARCTION, ISCHEMIC STROKE AND THEIR COMBINATION
Aim. Determination of the relationship of violations of structural and functional disorders of the heart, metabolic functions of the lungs and oxygen-transport function of the blood in patients with myocardial infarction, ischemic stroke, and their combination. Material and methods. Studies were conducted in 100 patients with myocardial infarction (MI), 60 with ischemic stroke (IS), 35 with combined MI and IS, as well as in 30 healthy donors. Among them, there were 122 men (62,5%), women - 73 (37,4%). The mean age of patients with MI was 54,4±1,4 years, IS - 56,4±1,4 years, MI+IS - 55,4±1,4 years. Assessment of hemostasis systems, metabolic functions of the lungs, acid-base state, oxygen transport function of the blood was carried out according to the main parameters in the pools of venous cubital blood (VKK), mixed venous blood (VK), outflowing arterial blood (OAK). We also studied the structural and functional parameters of the left (LV) and right (RV) ventricles of the heart. Results. In patients with myocardial infarction, IS, and their combination, processes of impaired delivery, consumption, and utilization of oxygen are noted, and peripheral blood shunting occurs. These processes directly depend on the staging of impaired metabolic functions of the lungs, the parameters of general and pulmonary hemodynamics, the severity of systolic and diastolic LV dysfunction, and other factors associated with the severity of the underlying pathology. Conclusion. The detected changes in the processes of delivery, consumption, utilization of oxygen, peripheral blood shunting and hypoxia are the links of the "vicious circle of critical condition" in this category of patients.