Substantiation for the use of sodium hypochlorite as a scolecide drug in the treatment of patients with multichamber hydatic echinococcosis of the liver. experimental study
The research purpose was to assess sodium hypochlorite water solution anti-scolex activity against Echinococcus granulosus protoscolexies and effect on secondary echinococcus cysts envelopes. Materials and methods: We preformed two in vitro trials of the sodium hypochlorite water solution 0.06%, 0.12%, 0.25%, 0.5%, 1%, 2% and 4%.Sodium hypochlorite water solution anti-scolex activity versus exposure and the concentration of the drug was assessed in the first trial. Two drops of sodium hypochlorite water solution of various concentrations were added to the drop of the echinococcal fluid with living protoscalexes. The morphological changes of the parasite were investigated with a light microscope with a 100X magnification. The death of protoscolexes occurred within the first minute after the addition of sodium hypochlorite water solution, irrespective of solution concentration. The effect of sodium hypochlorite water solution on the secondary Echinococcus granulosus cysts envelopes was evaluated in the second trial. Envelopes fragments of the secondary echinococcal cysts were placed in tubes with sodium hypochlorite water solution in different concentrations. The changes were evaluated macroscopically. The envelopes of the secondary echinococcal cysts were completely dissolved in all tubes with sodium hypochlorite water solution. Results: The experimental data have showed that sodium hypochlorite water solution is an effective anti-scolex medication enabling completely dissolution of the secondary echinococcal cysts envelops. Conclusions: Considering that sodium hypochlorite is thoroughly investigated and safe for human body, sodium hypochlorite could be “ultimate” antiscolex medication, enabling extension of indications and ad value for less invasive percutaneous interventions under radiation control in echinococcosis.