Hormonal shifts and intensity of free radical oxidation in the blood of patients with facial nerve neuropathies
Pathochemical characteristic features of facial nerve neuropathy (FNN) have been more accurately defined. Heterogeneous patochemical pattern of facial nerve neuropathy has been shown to be dependent on the severity of the disease, in-tensity of free radical oxidation processes, and hormonal status of the patient. We have found reliable distinctions in dynamics of free radical oxidation processes, and hormo-nal status in the blood of the patients with moderately severe and severe forms of facial nerve neuropathies. In facial nerve neuropathies we observed regulatory effects of cortisol and somatotropic hormone; in facial nerve neuropathywith moderate severity the hormones of thyroid group were seen to be switching off, falling out the processes regulating metabolism. Follicle stimulating hormone (FSH) and luteinizing hormone (LH) were found to have regulating effects, especially in the acute phase of the dis-ease. Different dynamics of the hormones in patients with high and low free radical oxidation levels suggests that the oxidative stress intensity could be associated with regulatory effects of the hormones. The results of correlation analysis confirm the re-liable distinctions in free radical oxidation characteristics and and cortisole levels, STH, FSH and LH levels.