INTESTINAL MICROBIOTA IN PATIENTS WITH PROGRESSIVE PSORIASIS AND ITS DYNAMICS AS INFLUENCED BY PHOTOCHROMOTHERAPY
Relevance. Relevance of this study is determined by an increasing number of psoriasis cases and increasing frequency of disease relapses, severe nature of pathological process, lack of definite ethiopathogenic data on occurrence of chronic dermatosis and lack of stable therapeutic effect. Purpose of the study. The purpose is to study qualitative and quantitative composition of intestinal microbiota in patients with psoriasis and its dynamics as influenced by photochromotherapy (narrow - band optical radiation of 540 nm and 650 nm). Materials and methods. We examined 27 (13 men and 14 women) patients with advanced psoriasis in a progressive stage. Average age of the examined patients was 46.1 years old. Control group included 116 healthy young people (66 men and 50 women) aged 20 to 35 years old, with no health complaints, including gastrointestinal complaints. Accompanied by a standard drug therapy, narrow - band optical radiation of 540 nm and 650 nm (photochromotherapy) was applied locally (on the lesion sites) using the laser - LED therapeutic device “Spectrum LC” (02 model), medical device registration certificate No. РЗН 2016/447 dated August 25, 2016. Results. Compared with the control group, patients with psoriasis showed a marked decrease in the total number of microbial markers, by almost 2 times, due to decreasing amount of beneficial microflora and aerobic flora. Number of microbial markers of Lactobacillus and Bifidobacterium reduced by 3 times, and those of Eubacterium/Cl. Coccoides - by 24 %. Proportion of Lactobacillus and Bifidobacterium microbial markers decreased by 39 % and 33 %, respectively; while proportion of Eubacterium/Cl. Coccoides and Propionibacterium/Cl. Subterminale microbial markers increased by 54 % and 89 %, respectively. Conclusion. A tendency of increasing number of microbial markers of beneficial microflora by 23 % due to increasing number of microbial markers of Eubacterium/Cl. Coccoides by 43% and Propionibacterium/Cl.Subterminale by 20 % was shown in patients with psoriasis receiving a standard treatment together with photochromotherapy (540 nm, green spectrum). Number of anaerobic flora microbial markers increased by 23 %. Thus, photochromotherapy (540nm, green spectrum) additionally stimulated growth of Propionibacterium/Cl. Subterminale . While in patients with psoriasis receiving a standardtreatment together with photochromotherapy (650 nm, red spectrum) a tendency to increasing number of microbial markers of Eubacterium/Cl Coccoides by 40 % and Lactobacillus by 18 % and decreasing number of microbial markers of Bifidobacterium by 30 % was shown. Thus, photochromotherapy (650 nm, red spectrum) additionally inhibited growth of Bifidobacterium.