TOXICOLOGICAL ESTIMATION OF MICROORGANISM <i>PAENIBACILLUS EHIMENSIS</i> IB 739 AND PREPARATION BACISPETSIN BM
The purpose of this study was an experimental assessment of the toxicity and hazard of plant growth regulator Bacispecin BM preparation and its active ingredient, the microbial strain Paenibacillus ehimensis IB 739. It was found that the microbial strain is not virulent, non-toxic, toxigenic, the ability to disseminate, does not have a significant dysbiotic effect on the microflora of the body. Has immunomodulatory effects and mild allergenic properties. Local irritant effect on the conjunctiva and skin is absent. The microbiological preparation Bacispecin BM on the parameters of acute toxicity and danger is of low danger and belongs to the products of the 4th hazard class. Local irritant effect on the skin and mucous membranes of the eyes is not manifested. The skin-resorptive effect is poorly expressed. Has immunomodulating effect and mild allergenic activity. Does not show a dysbiotic effect on the intestinal microflora. On the basis of experimental data, it has been established that low-grade allergic activity is the limiting criterion for the harmful effect on the body of warm-blooded animals, both the producer strain and the drug on its basis. The results of the studies lead to the conclusion that the preparation Bacispecin BM does not have medical and hygienic contraindications to use in agriculture as a regulator of plant growth.