Synthesis of New Polyheterocyclic Compounds Based on Chalcones
The reaction of methyl N -4-[2-(2-oxo-1,2-dihydro-3 H -indole-3-ylidene)acetyl]phenylcarbamate with tosylmethylisocyanide in tetrahydrofuran in the presence of potassium tert -butoxide results in methyl N -{4-[(4oxo-4,5-dihydro-3 H -pyrrolo[2,3- c ]quinolin-1-yl)carbonyl]phenyl}carbamate. By three-component condensation of methyl N -{4-[( E )-3-R-2-propenoyl]phenyl}carbamates and methyl N -4-[2-(2-oxo-1,2-dihydro-3 H -indole-3ylidene) acetyl]phenylcarbamate with sarcosine and paraform by boiling in toluene with azeotropic distillation of water were obtained methyl N -(4-{4-[4-R-1-methyltetrahydro-1 H -pyrrol-3-yl]carbonyl}phenyl)carbamates and methyl 4-(1'-methyl-2-oxospiro[indolin-3,3'-pyrrolidine]-4'-ylcarbonyl)phenylcarbamate respectively.