The level of expression of CD95-receptor lymphocyte apoptosis as a measure of early diagnosis of bronchial asthma in children
The target of the inspection was the definition of the diagnostic importance of apoptosis of peripheral blood lymphocytes at children with obstructive bron- chitis syndrome. As a result of research it has been re- vealed that a bronchial asthma and dermatorespirato- ry syndrome at children are characterized by the raised stability of peripheral blood lymphocytes to sponta- neous apoptosis (46,0±21,8; р<0,01 and 32,6±18,6; р<0,0001 respectively). Expression of CD95-marker of apoptosis of lymphocytes is characteristic for chil- dren with recurrent bronchitis comparable to the group of healthy children (56,7±8,0 and 59,8±9,6 respec- tively). Considering negative correlation dependence (=-0,8) between concentration СD95-marker of apoptosis and IgE, definition of level CD95-marker of lymphocytes apoptosis at children with hyperimmuno- globulinemia Е is recommended for the purpose of ear- ly diagnostics of bronchial asthma.