The dynamics of indices of lipid peroxidation of patients, who undergo the programmed hemodialysis
The study involved 52 patients being under scheduled haemodialysis (SHD), which were divided by the simple randomization method into two groups: the main group (of 28 persons given Atorvastatin, 20 mg once a day, within 90 days under SHD) and the comparison group (of 26 persons only being under SHD). The LPO activity was studied by using the induced biochemiluminescent method with the aid of biochemiluminometer БХЛ 07. The contents of LPO molecular products diene (DC) and trienoic (TC) conjugates as well as Schiff's bases (SB) were studied by spectrophotometer APEL PD 303 (Japan) and СФ 46 (Saint-Petersburg). It was ascertained that the dynamics of lipid peroxidation factors of patients with terminal renal deficiency being under scheduled haemodialysis both given and not given Atorvastatin, was unidirectional. It meant that the antioxidant system activity increased and the concentration of all analyzed lipoperoxidation products as compared to the initial level. With taking Atorvastatin for the studied category of patients the anti-oxidant system activity increase and the reduction of the contents of secondary lipoperoxidation products (trienoic conjugates) were more marked. It might testify the antioxidant activity of the preparation under study.