INTEGRATED ASSESSMENT OF BONE TISSUE CONDITION IN PATIENT WITH END-STAGE CHRONIC KIDNEY DISEASE
For an integrated assessment of the bone tissue condition in patient with end-stage chronic kidney disease 156 patients on continuous dialysis were examined. The osteocalcin and B-Cross-Laps levels were determined to be 7-10 times higher in the dialysis patients than in the healthy population due to an accelerated bone turnover and a decreased degradation and elimination of those markers. At the same time the osteocalcin level determination did not allow obtain valuable additional information about the bone disorders pattern in dialysis patients and the B-Cross-Laps level measurement could be used for assessing the bone resorption degree. No relation was found between highly prevalent disturbances of the calcium and phosphorus metabolism in such patients and the bone densitometry data. Nevertheless, this finding does not depreciate the importance of the calcium and phosphorus levels measurement for osteopenia diagnosis. To assess the bone tissue condition in dialysis patients adequately a complex investigation, including bone densitometry, measurement of the PTH, calcium, phosphorus, alkaline phosphotase, and in some cases, B-Cross-Laps levels is required.