THE LEVEL OF AUTOANTIBODIES TO MYELIN BASIC PROTEIN AND FEATURES OF THE MICROSTRUCTURE TRACTS OF WHITE MATTER OF THE BRAIN OF PATIENTS WITH ULTRA-HIGH-RISK GROUP FOR THE DEVELOPMENT OF SCHIZOPHRENIA
Objective: Analisis of the relationship between the level of AAB to MBP and markers of status pathways of the brain. Methods: 26 juvenile patients, identified psychopathological symptoms that meet the criteria for ultra-high risk of manifestation of schizophrenia were examined. To determine the level of AAB to MBP used enzyme-linked immunosorbent assay. MRI scan were performed: T1-weighted scan for each patients performed an automatic reconstruction of 18 white matter tracts by determining the fractional anisotropy (FA) and radial diffusion (RD) for each of the paths. Results: A correlation was found between the level of AAB to MBP and FA in the parietal part of the right upper longitudinal beam; between the level of AAB to MBP and rate of RD in the temporal and parietal parts of the right upper longitudinal beam. Conclusion. The decrease of fractional anisotropy is associated with the processes that cause violations of structure of the white matter, and increased radial diffusion with pathology of myelin sheaths. Revealed a certain interrelation of these processes with a high level of autoantibodies to myelin basic protein.