Interconnection cytokines and infectious factors in patients with chronic heart failure due to coronary heart disease
Investigation of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α), interferon gamma (IFN-γ) and antiinflammatory cytokine interleukin-4 (IL-4) and cytomegalovirus (CMV), Chlamydia pneumonia infections and herpes simplex virus (HSV) in the serum of patients with chronic heart failure due to ischemic heart disease. Investigation included 90 patients with ischemic heart disease (IHD) complicated by chronic heart failure (CHF). At clinical and instrumental assessment of patients IHD diagnosis was confirmed and functional class (FC) of heart failure was evaluated. Control group included 25 generally healthy persons. For all investigated patients and persons of the control group the contents of cytokines has been assessed: tumor necrosis factor- α (TNF-α), interferon-Y (IFN-γ), interleukin-4 (IL-4) and immunoglobulin classes G (IgG) and М (IgM), cytomegalovirus (CMV), chlamydia pneumoniae (CP), herpes simplex virus (HSV). Significant elevation of TNF-α, IFN-γ levels, IgG and Ig Mto CMV and IgM to HSV in patients with CHF, increasing along with FC of CHF was revealed. Significant correlation between contents of TNF-α, IFN-γ, IgM to CMV with EchoCG-signs reflecting systolic dysfunction of the left ventricle were revealed. Obtained results show activation of proinflammatory cytokines of possibly myocardial origin in patients with CHF of ischemic etiology due to CMV damage.