Phenotype of blood lymphocytes of patients with acute coronary syndromes in conjunction with anxiety-depressive disorder
To study the specific features of the T-and B-cell immunity in patients with acute coronary syndrome and comorbidity of anxiety-depression spectrum examined 59 patients in the first 24 hours after the onset of symptoms and on the 10th day of treatment. The diagnosis of acute coronary syndrome was established according to the recommendations of the Russian Science Society of Cardiology. Anxiety and depressive disorders were detected in the first 72 hours after being transferred from the intensive care unit using the Hospital Anxiety and Depression Scale, a questionnaire Beck, depression scale epidemiological studies Center USA and Spielberg-Hanin test. Using techniques of flow cytometry estimated phenotypic composition of T- and B-lymphocytes of peripheral blood. The studies found that patients with anxiety and depressive disorders as early as the 1st day of observation increases the content of T-lymphocytes (mainly due to T-helper cells and immature T-lymphocytes). In patients without anxiety and depressive disorders T-cell counts increased by the 10 th day of treatment and is associated with cytotoxic T lymphocytes. Independently of absence/presence of anxiety and depressive disorders in the peripheral blood of patients with acute coronary syndrome decreased content of T-regulatory cells. Set marked differences in phenotypic composition of B-lymphocytes and the number of B-cells expressing low-affinity receptor for IgE in groups of patients with acute coronary syndrome depending on the anxiety and depressive disorders.