Changes of oxidative-reductive balance in blood and brain of the ratin the neurodegenerative multifactorial simulator
The authors study activation of oxidative processes, changes of redox balance in the rat blood and brainstructures after injections of carbonyl iron, homopantothenic acid (GPA) and bacterial lipopolisaccharide (LPS). GPA is required for modeling for CoA homeostasis disorganization and carbonyl iron is required for an imitation of an iron accumulation in the basal ganglia, which represent the neurodegeneration caused by a defect of a mitochondrial isoform of a pantothenate kinase. LPS is injected for an initiation of an inflammation. The introduction of LPS or GPA following carbonyl iron leads to oxidative processe activations in blood plasma and erythrocytes especially when all the substances are injected simultaneously. Changes of the oxidative-reductive balance do not activate lipid peroxidation but increase redox balance by the changes of glutathione system through the glutathione enzymes which regulates glutathione oxidation-reduction. Therefore simultaneous injections of the carbonyl iron, LPS and GPA may be used for the simulation of the neurodegeneration caused by an oxidative damage and CoA biosynthesis changes in the nervous system.