ANALYSIS OF KLOTHO PROTEIN LEVEL IN PATIENTS WITH MYOCARDIAL INFARCTION AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN ACCORDANCE WITH SEVERITY OF AIRWAYS OBSTRUCTION AND DURATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASES
The research purpose was to analyze and compare the level of Klotho protein in patients with myocardial infarction (MI) and chronic obstructive pulmonary disease (COPD) in accordance with duration of COPD and severity of airways obstruction. Materials and research methods. The study design included three groups: the main group -patients with MI and COPD, n=60; the comparison group -patients with COPD, n=54; the control group -somatically healthy individuals, n=30. The main and the comparison group were divided into subgroups depending on the duration of COPD and severity of airways obstruction. Determination of the Klotho protein level (ng/mL) in the blood plasma of patients was carried out by the enzymelinked immunosorbent assay. Conclusions . According to the results of the study, it was found that the level of Klotho protein in patients with MI and COPD was statistically significantly lower than in somatically healthy individuals and in patients with COPD. In the group of patients with COPD and patients with MI and COPD, a statistically significantly lower level of Klotho protein was found in the subgroup of patients with a longer duration of COPD and with more severe severity of airways obstruction. In the group of patients with MI and COPD with the duration of COPD from 1 to 9 years and 10 years or more and in patients with II and III degrees of airways obstruction, the level of Klotho protein was statistically significantly lower than in the group of patients with COPD in the corresponding subgroup.