Role of nitric oxide in the regulation of peritoneal macrophages in rats offspring chronic disturbance of the uteroplacental blood circulation
Еxam of the activity of peritoneal macrophages, NO-dependent state and mechanisms of free radical pro- cesses in normal pregnancy and in the background of the experimental disturbance of the utero-placental circulation (DUPC) was done with using of white rats. With the introduction of L-NAME and DUPC in serum observed similar changes in the form of lower levels of total nitrate and nitrite, increasing free radical processes. Activity of peritoneal macrophages varies in the opposite way - L-NAME significantly increases her, and DUPC - decreases. When combined action of increased production of nitric oxide formation and nitrotirozine that under these conditions plays a protective role by providing adaptation impaired feto-placental blood flow to the needs of the fetus, the activity of mac- rophages corresponds to the intact rats.