PERFECTION OF WAYS OF PROTEIN QUALITY CONTROL IN IMMUNOGLOBULIN PERFECTION OF WAYS OF PROTEIN QUALITY CONTROL IN IMMUNOGLOBULIN PREPARATIONS
Collegiate and viscous properties of protein drugs was studied by the example of normal and anti-mite immunoglobulins. Constants in the Haller equation are defined. The linear view of the freezing temperature decrease of immunoglobulin concentrations is set. This allows to recommend method osmometry as an express and accurate method for determining the protein concentration in pharmaceuticals. It is shown that in the concentration range of 5-6% protein spherical globular conformation transfer in elliptical globular conformation. Demonstration of anisodiametric protein globules leads to deviations from the rules Van´t Hoff and equation Einstein. Quantitative determination of individual proteins in the preparations justified by the Lowry method. Validation evaluation of the proposed spectrophotometric method received. It is shown that the Lowry method corresponds to eligibility criterion.