Dynamics of Average Weight Molecules Concentration in Patients with Severe Concomitant Thoracic Injury in the Acute Period of Traumatic Disease
The substances which are responsible for the development of endotoxicosis in various pathophysiological conditions include average weight molecules. The objective of this work was to study the dynamics of the concentration of average weight molecules fractions in the blood plasma of patients with severe concomitant thoracic injury in the acute period of traumatic disease. The study involved 73 male patients aged 20 to 68 years with severe concomitant injury of the chest. Patients were divided into 2 groups: patients who have recovered and patients with a fatal outcome of traumatic disease. Blood sampling was carried out in 3 stages: on the 1st - 2nd, 3rd - 4th and 5th - 6th days after the injury. Average weight molecules were measured in the blood plasma of patients using spectrophotometric method. In patients who have recovered the dynamics of the concentration, peptide fractions and fractions with aromatic groups is characterized by growth on the 1st - 2nd days after injury with subsequent normalization. In patients with a fatal outcome of traumatic disease throughout the early post-traumatic period, endogenous intoxication was more severe in comparison with the group of patients who have recovered. Dynamics of the aromatic fraction of average weight molecules is experiencing more significant fluctuations during the early post-traumatic period, especially in patients with a fatal outcome of traumatic disease that is most likely due to more complex mechanisms of their detoxification. Concentrations of average weight molecules fractions can display the severity of endogenous intoxication, and can also serve as additional markers of prognosis in patients with severe concomitant thoracic injury.