INTERRELATIONS BETWEEN DISTURBANCES OF STRUCTURE, METABOLISM AND FUNCTION OF RATS KIDNEYS AT GENTAMYCIN INTOXICATION PART 1. STRUCTURAL AND METABOLIC INTERRELATIONS
It has been established that gentamycin-induced disturbances in nephron structure are associated with the inhibition of metabolism processes in them. According to the degree of interaction the indicators of matabolism are descending as follows: lactatdehydrogenase in proximal convoluted tubules (PCT) of cortical nephrons (CN) > alkaline phosphatase in PCT of CN = acid phosphatase in PCT of juxtamedullary nephrons > acid phosphatase in PCT of CN = ribonucleoproteins. The main gentamycin-induced metabolic disturbances in the kidneys are registered in PCT of CN and involve the inhibition of energetic exchange processes (according to the decrease in lactatdehydrogenase activity).