Clinical-laboratory study of antireccurent treatment of laryngeal papillomatosis in adults with the use of cyclooxygenase-2 inhibitor (celecoxib)
The study included 53 adult patients with frequently recurrent form of laryngeal papillomatosis (first group) and 18 - with a stable remission of the disease (the second group). The control group consisted of 10 people with traumatic nose diseases. All patients were conducted clinical tests, indirect laryngoscopy and fibrolaryngoscopy and analyzed the levels of prostaglandin Е in serum. Patients of the 1st group after the carried-out surgical treatment of a larynx received antirecurrent therapy with application of cyclooxygenase-2 inhibitor (celecoxib drug). Duration of remission period and the maintenance of prostaglandin Е in serum was estimated. High efficiency of this pathogenetic method of treatment is proved.