GENETIC DIVERSITY OF FRONTOTEMPORAL DEMENTIA
Frontotemporal dementia is progressive neurodegenerative disorder with clinical, genetic and pathomorphologic diversity. It is the third most common cause of dementia among all ages and the most common cause of dementia with early onset (before 65 years old). Despite its multifactorial nature, up to 40% of patient have positive family history, dominant inheritance is observed in a quarter of cases. This review reports on key genes, which mutations can lead to the development of frontotemporal dementia, describes possible pathogenic mechanisms of the degenerative process and provides information on clinical features of the disease, corresponding to different genetic variants. Particular attention is paid to the frontotemporal dementia associated with amyotrophic lateral sclerosis.