Tissue hypoxia in Crohn’s disease in children: markers and coping methods
Objective: to identify markers of tissue hypoxia in Crohn’s disease in children: markers and methods for overcoming it. Materials and methods: 27 children with Crohn’s disease (CD) aged from 1 year to 18 years were examined. Histological, histomorphometric and immunohistochemical analysis of biopsy samples of the colon mucosa. Results: morphological markers of tissue hypoxia in CD were identified: the presence of predominantly immature fibroblasts, infiltration of the muscle plate by neutrophilic granulocytes, necrotizing vasculitis, the phenomenon of the grouping of inactive macrophages with each other with the formation of multinucleated cells, which are the precursors of multinucleated granules according to the Pigorov-Lanhans type Conclusion: in identifying markers of tissue hypoxia, leading to a worsening prognosis of the course of CD and the development of complications, it is necessary to determine the tactics of accelerated “step-up” therapy using anticytokine drugs and use the method of hyperbaric oxygenation.