Correction by benzimidazole derivate based on thietanes of psychoemotional disorders caused by stress influence in the case of experimental animals
Possibility of correction of by benzimidazole derivatives based on thiethanes (potassium salt of 2-[1-(1,1-dioxyethenyl 3) benzimidazolyl-2-thio] acetic acid - BDT) psycho-emotional disorders caused by stress exposure in experiments on animals, has been evaluated in the present study. BDT was administered to laboratory rats on the background of stress factor - prolonged physical stress caused by the forced swimming. BDT prevented the adrenal mass increase and increase in the number of leukocytes in blood of animals as a result of the increased stress. Application of BDT on the background of prolonged physical activity has helped to prevent violation of behavioral responses, determined in the test «open field» in animals: emotional anxiety was reduced, the mobility and the total research activity of the rats was fluctuated around the normal level. Thus, the BDT can be considered as a potential drug for the correction for mental disorders caused by stress.