The role of epithelial-mesenchymal transition in carcinomas by different localizations (Part 1)
Epithelial-mesenchymal transition (EMT) plays an important role in the progression of malignant tumors, imparting invasive properties and metastatic potential, providing relative resistance to chemotherapy and radiotherapy, significantly worsening the prognosis for the patient. Morphological research methods, such as immunohistochemistry are able to indicate the presence of EMT, its prevalence and completeness, being the most important method for disease predicting. This review presents data on the role of regulatory genes and transcription factors in the induction of EMT, with the possibility of using it in new approaches to the treatment of cancer patients.