POTENTIAL VALUE OF PERFUSION AND DIFFUSION METHODS FOR SOLITARY WHITE MATTER LESION
P urpose. This study explores practical use of diffusion and perfusion on MRI. Materials and methods. 189 cases were examined during this study. It observed the following pathologies: stroke, demyelinating disease, abscess, glioma. All examinations were performed at 1.5T MRI. Scanning included T2-, T1-weighted imaging, FLAIR, DWI with ADC map, DCE, DSC or ASL. Results. The results demonstrate the importance of correlation between ADC values of the main lesion β coef. 0,49 (CI 0,23;0,74) p=0,00001 and perfusion values of perifocal changes. Infarction has minimal ADC value 0.46 (0.33;0.64) ×10-3 mm2/s and correlate with low perfusion values from perifocal lesions. Value data showed correlation and lower perfusion values of perifocal changes β coef. 0,68 (CI 0,52;0,85) p=0,00001. In case of abscess ADC value is 0.62 (0,6;0,65) × 10-3 mm2/s and has correlation with no deviation of perfusion values of perifocal changes. In case of pseudotumor form of multiply sclerosis it is 1.03 ± 0.15 × 10-3 mm2/s and has correlation with no deviation on perfusion maps. In case of high-grade glioma ADC value is 0.69 ± 0.03 × 10-3 mm2/sand is less than low-grade glioma and correlate with more high perfusion values. Discussion. We estimated ADC and perfusion values for the main lesion and for perifocal changes in case of a solitary white matter lesion for differential diagnosis. It can be used for optimal algorithm of differential diagnostics for white matter solitary lesions. Conclusion. Multiparametric MRI protocol with assessment of ADC and perfusion values must be used for differential diagnostics of solitary white matter lesions. In some cases, it is critically important to assess perifocal changes as well as the main lesion.