EFFECTS OF р-ENDORPHIN AND [D-ALA <sup>2</sup>, N-ME-PHE <sup>4</sup>, GLY <sup>5</sup>OLj-ENKEPHALIN ON THE LYMPHOCYTE PROLIFERATIVE ACTIVITY UNDER THE OPIOID RECEPTOR BLOCKADE IN VITRO
Under the opiate receptor blockade with naloxone hydrochloride the influence of в-endorphine and [d-Ala <sup>2</sup>,N-Me-Phe <sup>4</sup>,Gly <sup>5</sup>-ol]-enkephalin (DAGO) on lymphocyte proliferation response being induced by phytohemagglutinin has been studied in vitro. It was found that in vitro both в-endorphine and DAGO rendered promoting effect on lymphocyte functional activity. Their effect was not prevented with naloxone, but was blocked with naltrindole. Under the assessment of factors contributing to regulation of proliferation response it was determined that в-endorphine, DAGO, and naloxone exerted separate, mutually independent stimulating effects on pro-liferative activity of peripheral blood lymphocytes mainly under low mitogenic stimulation.