Acute phase proteins lactoferrin and ceruloplasmin in ulcer disease of stomach and duodenum
The clinical and pathogenical significance of lactoferrin (Lf) and ceruloplasmin (CP) in gastric and duodenal ulcer disease was evaluated. In acute phase of ulcer disease the level of Lf and CP was elevated 2- fold and 2,8- fold accordingly while in remission it was normal. There were no correlation between clinical manifestations and Lf and CP level. In helicobacter-positive patients the level of Lf and CP was higher than in helicobacter-negative patients. These findinsg suggest that the increase of Lf and CP in acute phase of ulcer disease was pathogenically beneficial and led to improved reparation of ulcer defect and increased antimicrobial resistance.