EARLY PATHOGENESIS MECHANISMS OF KIDNEY AND LIVER LESIONS WITH BREAKING OXIDATIVE PHOSPHORYLATION
From the positions of probative medicine the work presents theoretical substantiation and a new approach to solve the scientific task concerning early pathogenesis mechanisms of pseudohepatorenal syndrome as the basis to deteriorate the course of kidney and liver failure with breaking oxidative phosphorylation under conditions of 2,4-dinitrofenol administration. An increase of the concentration of the blood plasma tumor necrosis factor-α, interleukin -1β, interleukin -6 and development of the syndrome of the urinary loss of sodium ions with a growth of the excretion and clearance of the cation under study have been established in experiments on 120 albino outbred male rats with the body weight of 0,16-0,20 kg fed on low-sodium diet with tissue hypoxia modeling. A protective effect of exogenons melatonin has been established on the degree of oxidatively modified proteins in the kidneys and liver of rats with lowered the level of the R/B coefficient in the proximal, distal portions of the nephron, the collecting tubules of the renal papilla and the protein masses of the cytoplasm of hepatocytes.