Effect of the Photosensitizers Pheophorbid <i>a </i>and Protoporphyrin IX on Skin Wound Healing by the Action of Low-Intensity Laser Irradiation
The effect of photosensitizer with subsequent He-Ne (632.8 nm; 3 mW/cm<sup>2</sup>) laser irradiation on experimental skin wound healing has been studied. Pheophorbid <i>a </i>and protoporphyrin IX were used as photosensitizers. It was found that the application of the photosensitizer and subsequent laser irradiation, first, decreased the amount and the functional activity of leukocyte in wound excudate and, second, inhibited the SOD-activity, compared to that of the control group. Moreover, pheophorbide <i>a </i>and protoporphyrin practically did not affect the total healing period but decreased the length of the inflammation stage. It was supposed that these effects are related to the generation of reactive oxygen species during irradiation.