Use of metformin in patientswith prediabetes and chronic heart failure (Rewiev)
High prevalence of chronic heart failure (CHF) and type 2 diabetes mellitus (T2DM) combination, worse prognosis by increasing cardiovascular complications, determine the relevance of prediabetes detection, strategy definition and optimal therapy tactics. It is not easy to choose effective glucose-lowering agent, taking into account the possibility of impact on postprandial glycemia and insulin resistance, considering their crucial role in both T2DM and CHF. They should not worsen CHF course. On other hand, for CHF decompensation management it is important to take into account drug`s influence on carbohydrate metabolism to avoid T2DM development ant it`s progression. This review is dedicated to a representative of the biguanide class - metformin, which proved effectiveness and safety for diabetes prevention in general population. However, patients with CHF and prediabetes remain poorly explored.