Polymorphous variants of genes ABCB1, TGFBR1, IL10 and VDR in normal control cohort and in patients with sporadic renal cancer
Annually over the world approximately 190 thousands of new renal cancer cases are been diagnosed, that makes it one of the main problem in oncourology. In the present study ABCB1, TGFBR1, IL10, and VDR genes polymorphisms were been determined by the method of minisequencing in control and in sporadic renal cancer, comparative analysis of rates of alleles and genotypes in various clinical groups of patients was been performed with the aim of search of prognostic criteria for this disease. The rates of genotypes of Taq1 polymorphism in the VDR gene were shown to be significantly differed between control group and patients with sporadic renal cancer ( p = 0.025), the incidence of Int7G24A allele A of the TGFBR1 gene was been revealed to be reduced in patients with metastases at the moment of establishing diagnosis ( p = 0.012). It is worthwhile further researching these polymorphisms in gross samples of renal cancer patients. Results of this investigation can promote the development the system of prognostic markers of sporadic renal cancer.