Synthesis of Hybrid Compounds Based on 2-(4-Carboxybenzylidene)-3,4-dihydronaphthalen-1(2<i>H</i>)-ones
On the base of 2-(4-carboxybenzylidene)-3,4-dihydronaphthalene-1(2 H )-one and 3-(1,3-dioxobutane-1-yl)-2 H chromene-2-one in the presence of nitrogen base (piperidine, triethylamine, or pyridine), for the first time the synthesis of hybrid systems containing pharmacophoric fragments of the interacting substances, has been performed. The scheme of the latter ones formation contains a condensed dihydropyran structure which undergoes aromatization into a benzodihydrochromilium salt under the hydrochloric acid action. The process may be accompanied by the competing azanucleophile addition by the double bond of the chalcone.