INFLUENCE OF PREOPERATIVE PREPARATION BY GONADOTROPIN-RELEASING HORMONE (AGNRH) ON OVARIAN RESERVE IN WOMEN OF REPRODUCTIVE AGE WITH OVARIAN ENDOMETRIOSIS
The aim was to study the effect of GnRHa perioperative application on ovarian reserve in women of reproductive age with ovarian endometriosis. We observed 199 women of reproductive age who had surgery laparoscopic ovarian endometriomas about: group A (n = 63) - did not receive any hormonal treatment before and after surgery; Group B (n = 62) - received aGnRH within 3 months after the operation; group C (n = 74) - received aGnRH for 2 months before and 3 months after surgery. The control group consisted of 30 conditional somatic and gynecological healthy fertile women of reproductive age with a regular menstrual cycle. Ovarian reserve indicators were studied before and after treatment: the level of AMH, inhibin B, FSH, the antral follicle count. It was found that the persistence of endometriomas in the ovaries of women of reproductive age leads to a decrease in ovarіan reserve. Postoperative GnRHa application does not affect the ovarіan reserve in women with endometriosis, aGnRH as preoperative application (no more than two injection) combined with postoperative one leads to a reduction of ovarian reserve damage after surgery.