SYNTHESES OF 1-(2-NAPHTHIL)-4-ETHOXYBUTANDIONE-1.3 AND ETHOXYMETHYLNITROSOPYRAZOLE BASED THEREON
Pyrazole derivatives are used as pharmaceuticals. Analgin, amidopyrine, antipyrine and other classic pyrazole-based remedies are broadly used in the pharmacology. According to the literature derivatives naphthyl substituted pyrazoles are compounds that exhibit fungicidal and antibacterial activity. In this paper we present data on the synthesis of previously unknown 1-(2-naphthyl)-4-ethoxybutandione-1.3 by Claisen condensation reaction of ethyl ethoxyacetate and 2-acetonaphtone. On its basis the result of nitrosation with sodium nitrite in acidic medium was first isolated 1-(2-naphthyl)-4-ethoxybutane-1,2,3-trione-2-oxime. By reacting 1-(2-naphthyl)-4-ethoxybutane-1,2,3-trione-2-oxime with hydrazine hydrate in an aqueous alkaline medium has been synthesized previously available 5-ethoxymethyl-4-nitroso-3-(2-naphthyl)-1H-pyrazole. The structure of synthesized compounds was proved by UV, NMR1H, IR spectroscopy and mass spectrometry.