THE RESEARCH OF ACTIVITY OF PROTEOLYTIC ENZYMES IN MALIGNANT TUMORS OF THE BREAST, STOMACH, INTESTINES AND KIDNEYS OF HUMAN
The article analyzes some of the key enzymes of modification, processing and degradation of regulatory peptides - cathepsin D, carboxypeptidase E and PMSF-inhibited carboxypeptidase in malignant and benign tumors of human’s breast, stomach, intestines and kidneys. It is showing a marked increase in the activity of the studied enzymes in malignant tumors, which may cause increased production of regulatory peptides and growth factors involved in carcinogenesis. The results has a practical value and can be the basis for the development of new methods of diagnosis of malignant tumors and the creation of an extensive database-oriented health care providers. The role of specific proteolytic enzymes in the etiology and pathogenesis of malignant tumors of various tissues and organs are discussed.