PREVALENCE AND DETERMINANTS OF BONE REMODELANCY DISORDERS IN PATIENTS WITH DIABETES
The article presents the results of structural change and functional state of bone in patients with diabetes mellitus. Total of 235 patients aged 40 to 70 years, of these, 98 (41 men, 57 women) type 1 and 137 (52 men, 85 women) type 2 diabetes patients were included in the study. DM1 duration 16,6±0,6 years, BMI: 26,1±0,2 kg/m<sup>2</sup> and DM2: 8,1±0,7 years, BMI: 30±0,4 kg/m<sup>2</sup>. Investigated the level of 25( OH ) D, PTH, serum bone remodeling markers ( ALP, PINP, b-CTx ) and DXA. The results of the study demonstrated that the content of serum bone remodeling markers in patients with DM1 and DM2, in comparison to the control group, indicate pathological processes in bone remodeling with decrease bone formation marker PINP in patients with DM1 by 16 %, with DM2 by 12 % in comparison with the control and an increase bone resorption marker b-CTx by 32 % with DM1 and in 25 % patients with DM2, of whom of women were 1,5 times more than men. Patients with DM2 had lower b-CTx values and a relatively higher level of P1NP, which reﬂects a less pronounced change in bone turnover compared to patients with DM1, regardless of age and duration of disease. T -score BMD of L 1- L 4 area was reduced in 64 and 44 % of patients with DM1 and DM2; T -score BMD of femoral neck area - in 41 and 36 % of patients. These results suggest that bone disorders and related fractures, is a clinically signiﬁcant and commonly underestimated problem in diabetes.