Morphofunctional features of the pial arteries adjacent areas of cerebral blood flow in acute circulatory hypoxia
Background. Zones of adjacent blood supply of pial network of the brain have the greatest vulnerability in hypoxia. Nevertheless morphofunctional studies of these areas of the vascular bed in the circulatory ischemia was not conducted. Methods. Ischemic disorders of brain modeled in rats by ambilateral ligation of the common carotid arteries. Estimated vasomotor activity of pial arteries zones of adjacent blood supply of frontal and parietal regions with Kernogan index. By scanning electron microscopy were determined three-dimensional structure of pial arteries in areas of adjacent blood supply. Results. Dynamics of changes in vasomotor activity of pial arteries in the circulatory ischemia was as follows: after 10 min began vasodilatation, reaching a maximum in 20 minutes. After 30 minutes, marked the return of value of the vascular lumen to the basic. After 40 minutes, the second wave of dilatation developed. During this period there was eritrodiapedesis. Conclusions. The most labile section of the vascular bed of rat brain arteries are the frontal and parietal regions of 50-69 microns in diameter, which play the most important role in the adaptation of the brain to hypoxia.