The role of papillomavirus in the development of tumors of the oropharyngeal zone and diagnostic features of HPV
Given the growing role of human papillomavirus infection in carcinogenesis of squamous cell carcinoma of the head and neck, the understanding that HPV-associated cancer and HPV non-associated cancer are two different nosological forms of oropharyngeal cancer, the lack of common standards and approaches in the diagnosis of HPV infection. Therefore, the main objective of the oncological society is to introduce into clinical practice high-precision, cost-effective, optimal, technically feasible laboratory method for the diagnosis of HPV-associated oropharyngeal cancer. This review of the literature reflects modern views on carcinogenesis and diagnostic methods for HPV-associated oropharyngeal cancer, analyzes the strengths and weaknesses sides of the methods, as well as the difficulties that doctors face in their clinical practice in diagnosing HPV in various materials (cytological and histological).