CONGENITAL AND ADAPTIVE IMMUNITY IN FREQUENTLY ILL CHILDREN WITH HERPES VIRUS MARKER INDICATION
178 children aged 1 to 5 years were examined using PCR with quantitative DNA CMV indication in nasopharyngeal samples of 66 children, DNA EBV - 49 children, and DNA HHV6-132 children. Herpes virus DNA associations (CMV, EBV, HHV6) in nasopharyngeal samples of frequently ill children (FIC) were identified significantly more often (56%) compared to those of episodically ill children (EIC) - 36% (p<0,05), and DNA HHV6 indication in nasopharyngeal samples was prevailing in EIC - 52% versus 27% of FIC (p<0,05). We studied association between quantitative herpes virus DNA indication rates in FIC and parameters of congenital and adaptive immunity. The association between the value of viral load of DNA EBV and production of IFN-y in blood (r= -0,63, p=0,038), IL-4 (r= -0,63, p=0,037), CIC (r=0,69, p=0,007), and IgE (r= -0,39, p=0,047) was found. The value of viral load of DNA CMV correlated to TNF alpha (r=0,59, p=0,02), IL-4 (r=0,51, p=0,038), and IgA (r= -0,69, p=0,001). The viral load of DNA HHV6 in nasopharyngeal samples demonstrated poor correlation (r= -0,28, p=0,048) with a congenital immunity marker (CD3CD16+CD56+). The presented findings may contribute to the improvement of FIC rehabilitation technologies.