Impact of Contrast Media on Renal Function and Homeostasis in Children with Nephropathies
Aim. To investigate safety of contrast media (CM) in children with nephropathies and to study an impact onto renal function and homeostasis. Materials and methods. Intravenous pyelography (IVP) was performed in 60 children aged 3-17 years. Glomerular filtration rate (GFR), acid-base and electrolyte balance, serum cystatin C and endothelin, blood pressure and coagulation tests were performed before and after CM. Results. After CM use we observed elevation of serum cystatin C and endothelin, decrease of sodium fractional excretion and hypocoagulation. Conclusion. We suppose renal hypoperfusion with a consequent decrease of sodium fractional excretion and elevation of endothelin production may play a role in contrast-induced nephropathy (CIN). Elevation of serum cystatin C is a sensitive marker of renal function deterioration. Coagulation disorders must be excluded before CM use.