FORMATION OF COLOSTRAL IMMUNITY AND NONSPECIFIC RESISTANCE IN NEWBORN CALVES-TRANSPLANTS AS RESULT OF USING IMMUNOTROPIC PREPARATIONS OF MICROBIAL ORIGIN
The aim of the study was to study the effect of immunotropic drugs of natural origin - sporonormin liquid and sporoprotectin on the immunobiological state of recipient cows in the third trimester of pregnancy and calves obtained from them. To accomplish the goal, two groups of Simmental calf recipient cows were selected, to which embryos from Hereford cows were transplanted. Recipient cows were injected intraperitoneally with 5 ml of sporoprotectin 30 days before calving, and sporonormin was administered with concentrates at a rate of 0.5 ml per kilogram of live weight for a week. Starting from a month of age, the experimental calves showed a tendency to a more intensive gain in body weight, and this process proceeded more energetically in the young experimental group. It has been established that immune deficiency in newborn transplant calves arises as a result of immaturity of immunocompetent organs, which must be activated at the final stages of intrauterine development. The use of immunotropic drugs of microbial origin allows reviving immunogenesis by the first month of the calf’s life. At 2 months of age in terms of their immune status, calf grafts under the influence of immunotropic drugs had a noticeable advantage both in the humoral line of defense and in the cell line.