FREE RADICAL OXIDATION OF LIPIDS OF THE SKIN OF THE EXPERIMENTAL WHITE RATS WITH IRRITABLE CONTACT DERMATITIS WITH DIFFERENT METHODS OF TREATMENT
Purpose: to comparatively assess the state of free radical oxidation of skin lipids in experiments on white rats with irritable contact dermatitis the influence of containing omega-3 and omega-6 polyunsaturated fatty acids, and also anti-inflammatory agents and antioxidant action. Material and methods: 71 albino rats were caused irritant contact dermatitisand were treated different groups of animals by containing polyunsaturated fatty acids the Cream "Vitamin Ф99" rich and Radevit ointment. Evaluated the blood content of malondialdehyde, activity of superoxide dismutase and catalase. Results: most favorable dynamics on free radical oxidation of skin lipids and antioxidant system was after treatment with externally Cream "Vitamin F99" rich containing omega-3 and omega-6 polyunsaturated fatty acids. Summary: we proved the advantage of the products containing omega-3 and omega-6 polyunsaturated fatty acids effect on free radical oxidation of skin lipids in experimental irritant contact dermatitis.