Clinico-immunopathogenetic features of allergic diseases in the industrial region of Donbas
The results of examination of 535 patients with al- lergic diseases are presented in the article. The role of the most important provocative factors in pathogenesis of allergic diseases, such as exoallergens, infection and chemical substances were proved. Specific immunore- activity was characterized by polyvalence of sensibili- zation. The contact with industrial harmfulness resulted in formation of the infectious syndrome of the immu- nopathology, disenzymemia, and vegetative bronchi- al dysfunctions. Professional contact with technogenic pollutants had leaded to the cholinergic mechanism of hyperreactivity of bronchi at 98,5% patients with re- spiratory displays of allergic diseases. The immunolog- ical and nonimmunological links of pathogenesis and those factors, which play a leading role in the genesis of relapses of allergic diseases, were distinguished. On basis of nosotropic features, the definition of allergic diseases is specified as the multifactorial pathology.