MORPHOLOGICAL CHANGES IN LUNGS OF RATS WHILE "SHOCK" LUNG MODELLING IN 1, 24 HOURS FROM THE MOMENT OF OLEIC ACID INTRODUCTION
As a result of “shock” lung modelling on rats by introducing oleic acid it`s determined that morphological changes in lungs against the background of acute respiratory distress syndrome are non-specific. The clinical picture of morphological changes in the lungs is multivarious: micro-thrombi, consolidations, interstitial and intra-alveolar edema, areas of mesenchymal proliferation, parenchyma haemorrhages, hyaline membranes, atelectases, fat embolism, bronchial pneumonia. The morphological study showed that the general changes for all periods of observation were combinations of multiple lobular atelectases with microcirculation disturbances. In 24 hours in some areas of lobular atelectasis together with sludges there was an accumulation of granulocytes, lymphocytes and formation of diffuse lymphoid tissue. In some animals there were hemorrhages under pleura, i.e. different degree edema in lung parenchyma.