PROGNOSIS OF THE MAMMALIAN CELL RADIOSENSITIVITY INCREASE UNDER SEQUENTIAL ACTION OF HYPERTHERMIA AND IONIZING RADIATION
The results of theoretical analysis of the possibility of the mathematical synergistic model application to the interpretation and prognosis of the radiosensitivity increase of mammalian cells sequential action of hyperthermia and ionizing radiation. Previously developed mathematical model of simultaneous and sequential action of two agents tested for yeast cells is tested for mammalian cell line. The model predicts the value of the thermal enhancement ratio depending on the thermal exposure duration and the ratio of damages induced by acting agents, the maximum value of the ratio, and a condition under which it occurs. The model predictions are in agreement with tested experimental data.