THE PARAMETERS OF OXIDATIVE STRESS AND INDICES OF HEART RATE VARIABILITY IN YOUNG PERSONS WITH THE RISK OF SUDDEN CARDIAC DEATH
The analysis of indicators of oxidative stress, antioxidant enzymes activity and heart rate variability in young persons with risk of sudden cardiac death. The study took into account the presence of anatomical, electrical or mixed substrate and trigger factors for the development of sudden cardiac death. In individuals with risk of sudden non-coronary cardiac death occurred the phenomenon of oxidative stress, manifested as an increase in the intensity of free radical oxidation and decreased activity of antioxidant enzymes, which may indicate a role of oxidative stress in the development of myocardial electrical instability and sudden cardiac death. Also showed a reduction in the power frequency range of indicators spectral and temporal analyses of heart rate variability, reflecting the tone of the parasympathetic nervous system, and thus serves as a manifestation of decreasing vagal protection arrhythmogenic effects of the sympathetic nervous system. Therefore, to improve the prediction of myocardial electrical instability, it is advisable to use a combination method of heart rate variability assessment indicators of the intensity of free radical oxidation and antioxidant system activity.