INFLUENCE OF IMBALANCE OF PROTEOMIC SPECTRUM AMNIOTIC FLUID ON FORMATION FETAL GROWTH RETARDATION
The proteomic analysis of amniotic fluid taken in the second trimester of physiological pregnancy and pregnancy, complicated fetus growth restriction (FGR) is carried out. Using the time-of-flight mass spectrometry identified 6 proteins of difference which are absent (insulin-like growth factor-binding protein-1 (IGFBP-1), epidermal fatty acid-binding protein, retinol-binding protein 4, placental lactogen, haptoglobin and peroxiredoxin-2) and 6 - appearing at FGR (zinc-a-2 glycoprotein, fragments of IGFBP-1, CDC37-like protein NKG2D ligand 2, hippocalcin-like protein 1, alpha-1-microglobulin/bikunin precursor). Discusses the importance of the identified changes in prteomic spectrum of amniotic fluid in the mechanisms of the development FGR. The identified proteins differences may serve as early markers of this obstetric pathology.