Modification of metabolic disorders in the pathogenesis of spontaneous preterm birth
Objective. To determine the levels of interleukins, neopterin, S100β protein in amniotic fluid and cord blood, show their role in the pathogenesis of preterm birth and perinatal injury of the central nervous system (CNS) in newborns. Patients and methods. The study included 77 women randomly selected by simple randomization. A single-center, singlestage, controlled, randomized trial was conducted, which included 77 women comprising two groups: the main group -33 patients with spontaneous preterm birth (35-37 weeks) and the control group - 44 women with the physiological course of pregnancy and childbirth (38-40 weeks). All newborns were also examined. The levels of interleukins IL-33 and IL-4, as well as neopterin and S100β protein were determined in amniotic fluid and cord blood by a solid-phase enzyme-linked immunosorbent assay (ELISA). Results. It was found that the increased production of interleukins and neurospecific proteins under study have a negative effect on the body of the pregnant woman and the fetus, which leads to serious pregnancy complications such as premature birth and perinatal CNS injury. Conclusion. The identified patterns provide a basis for the development of schemes for predicting preterm birth, which will improve perinatal outcomes and the health status of newborns.