Diagnosis of Diffuse Cystic Mastopathy Associated with Hormone Imbalance
Study Objective: To develop an ultrasound-based mathematical model to detect diffuse form of benign mammary dysplasia (BMD). Materials and Methods: A total of 269 women (mean age, 30.4 ± 0.3) were examined as part of the Female Health Program, a targeted interministerial practical and research program. The main group included 223 patients with diffuse form of BMD, and the control group included 46 apparently healthy women. Diffuse BMD was verified using ultrasound, dynamic contrast-enhanced MRI, and X-ray mammography. Study Results: All examination data were used to create a sequence, with signs of the disease being ranked in descending order of diagnostic value. The signs that had low diagnostic value were excluded; then diagnostic coefficients (DC) were calculated. For each form of diffuse BMD, decision rules were determined, based on DC and their diagnostic value. These rules were used to create a mathematical model to diagnose diffuse BMD in about. This model helps verify the form of diffuse BMD and assess treatment outcomes, based on principles of evidence-based medicine. Conclusion: When used to compare and assess imaging data from patients with diffuse form of BMD, mathematical modelling helps create a diagnostic algorithm and determine DC for each form of diffuse BMD. The resulting decision rules, in the form of diagnostic charts, help detect this condition in about mathematical modelling 78.6-94% of cases.