Intravascular changes in patients with arterial hypertension complicated with ischemic stroke
Aim. To study the extensiveness and character of intravascular auto rosette formation and to measure the thickess of intima-media of internal carotid artery in patients with AH complicated with stroke. Material and methods. Totaly 102 patients included (39 males, 63 females, mean age 67,1) with AH, complicated with ischemic stroke. Comparison group consisted of 121 patient with non-complicated AH of 2-3 stage (61 males, 60 females, mean age 63,9). All patients underwent laboratory sampling of capillary blood, and in blood smears the following were evaluated: total leucocytes, total number of auto rosettes and autorosettes with lysis. Also the intima-media thickness was measured in intrinsic carotid artery (by Philips IU-22, Netherlands). Control group consisted of 44 healthy volunteers (men 21, women 23, mean age 47,45). Results. It was shown that in AH with ishemic stroke extensiveness of intravascular auto rosette formation (21,7 and 1,2 times, resp.) and intima-media thickness (1,6 and 1,2 times, resp.) were higher than in healthy volunteers and patients with non complicated AH. First time there were rosette forming stab neutrofiles found in ischemic stroke, basophils and in quite large amounts platelets. The significant correlation is found for auto rosette formation and intima-media thickness of intrinsic carotid artery in non-complicated AH (r=0,45; p=0,005) and compicated by ischemic stroke (r=0,78; p=0,001). Conclusion. It can be suggested that rosette forming cells of the blood take part not only in pathogenesis of ischemic stroke and microcirculation, but in structural remodeling of brain vessels in patients with arterial hypertension.