GENDER FEATURES OF EARLY STENOTIC LESIONS OF CORONARY ARTERIES IN HIGH-RISK PATIENTS WITH THE PRESENCE OF MULTIFOCAL ATHEROSCLEROSIS
The aim of the study was to identify individuals with increased frequency of early symptoms of stenosing atherosclerosis of the coronary arteries with consideration of the peculiarities of comorbid abnormalities in CHD patients high risk with the presence of MFA. Materials and methods. Patients of middle age were divided into 3 clusters by the method of hierarchical analysis of categorical variables according to the clinical manifestation of atherosclerotic lesions of the heart, brain and arteries of the lower extremities. Patients evaluated the clinical status, ECG, CAG, echodopplerography carotid and lower limb arteries. According to the indications, magnetic resonance imaging of the chest and abdomen, spirography, fibro-gastroduodenoscopy, ultrasound of the abdominal cavity and kidneys, if necessary, ultrasound of the pelvis were performed. Results. It was found that one of the manifestations of coronary artery disease was ACS with hemodynamically significant PKA stenosis (76-90%), which developed in 50% of women with primary lesion of the 3rd segment of PKA, belonging to the 3rd cluster of the examined. The structure of hemodynamically significant changes in LCA branches was dominated by men of the 1st cluster with lesions of the 6th segment of PHA, DV, 15 segment of OA, while unstable angina was established in 54,2% of them, in the anamnesis - in 51,1%. Frequency of the level of the border of stenosis (50-75%) branches LKA showed a male predominance of the 1-St cluster with a lesion of the 6th segment PMRA involving DV and 15 of the OA segment, coupled with clinic stable angina. Conclusion. The nature of coronary vessels lesions in men and women of the middle age category revealed persons with an increased frequency of signs of stenotic remodeling, taking into account the clinical symptoms and features of vascular comorbid burden in patients with high-risk IHD with the presence of MFA.