Synthesis and Anti-Microbial Activityof Glycyrethic Acid Benzylidenhydrazides
The synthesis was carried out and the antimicrobial activity of the new derivatives of Glycyrrhetic acid containing hydrazide pharmacophore groups was evaluated. The greatest antimicrobial activity was shown by 3‑O-acetyl-N''-(4-hydroxybenzylidene) glycyrrhetic acid hydrazide. This compound had an antibacterial effect against Escherichia coli, Proteus vulgaris, Klebsiella pneumonia, Staphylococcus aureus, Citrobacter diversus, Enterobacter aerogenes, Pseudomonas aeruginosa, Enterobacter cloace, as well as antifungal activity against the fungus Candida albicans. The minimum inhibitory concentrations of this compound and pimafucin for Candida albicans were similar.