Influence of subclinical hypothyroid dysfunction on clinical and laboratory parameters of patients with rheumatoid arthritis using selenium
Objective: To study the effect of selenium on clinical and laboratory indicators in patients with rheumatoid arthritis with subclinical hypothyroid dysfunction. Material and methods. The study included 78 patients with the established RA in combination with CGTD. All patients have a comprehensive clinical and functional, instrumental and laboratory survey of rheumatoid arthritis and thyroid dysfunction. In order to correct the CGTD and increase the effectiveness of the treatment of the main disease, we have been providing a complete treatment, which included the appointment of sodium selenite preparation except for standard therapy within 6 months. Research results. The study showed that in RA patients with concomitant DHTD, after treatment according to a complex scheme with the inclusion of sodium selenite, the indices of articular syndrome and rheumatoid inflammation activity improved, the levels of TSH and aTPO decreased, and the number of patients with elevated levels of aTPO decreased. Conclusion. The use of sodium selenite in the complex therapy of patients with RA with CGTD is an effective method of correction of the articular syndrome, reducing the levels of inflammation markers and manifestations of the autoimmune process as a whole, which is very important and necessary to prevent the progression of the disease.