ACUTE EFFECTS OF NOVEL PSYCHOACTIVE SUBSTANCES IN CLINICAL PRACTICE: A LITERATURE REVIEW
Background. Novel psychoactive substances (NPS) present a new drug threat emerged on the world stage in the middle 2000s. An increasing number of literature data demonstrate the harmful nature of this class of psychoactive substances. The aim: the analysis of literature data and the structuring of clinical symptoms caused by particular NPS. Search strategy. Within the framework of the paper the authors carry our an analysis of 94 Russian - and English - language publications describing acute clinical symptoms of NPS intoxication and retrieved from PubMed, Google Scholar, «e-library» and «CyberLeninka» databases. The search process covered original full - text articles over the past 10 years, describing the clinical aspects of acute intoxication of NPS. Literary reviews, information letters and descriptions of the toxicodynamic aspects of the NPS were excluded from the analysis. Results. The paper presents the table that structures the most typical toxic effects of particular NPS and could be useful for clinical practice of drug addiction psychiatrists and toxicologists. Conclusions: publications on the clinical aspects of acute intoxication of the NIP cover description of cases/ series of cases. A variety of toxic effects is an actual problem for clinicians, since in a number of cases it is associated with severe multi-organ complications up to fatalities.