ANTIFOLATES FOR ANTICANCER CHEMOTHERAPY. PART IІ
In the review the structure of the basic antifolate antagonists, their intracellular enzyme targets, and their mechanisms of antitumor activity were considered. Folate antimetabolites, which were discovered in the last decade and trends in finding powerful inhibitors of folic acid metabolic pathways, were discussed in details. The advantages and limitations of antifolates that can be used for the design of new drugs for antitumor chemotherapy were considered.