Fetal alcohol syndrome: pathogenetic bases
The analysis of the literature on the problem of the formation of fetal alcohol syndrome. Draws attention to a number of hypotheses to explain the mechanisms of FAS. This, above all, teratogenic effects of ethanol on the embryo and fetus and genetic defects biotransformation systems in relation to ethanol in pregnant women and the fetus. Based on the conducted literature search and own research the authors propose a hypothetical pathogenesis of this embriofetopatii, which reflects the epigenetic nature of violations, and the change in the concentration of growth factors, recognized as one of the leading mechanisms of clinical manifestations of disease, as the lag in physical development in utero (delay fetal development) and in the postnatal period. For the same reasons morphological and clinical signs of underdevelopment of the central nervous system, cerebral and facial skull, visual and auditory analyzers and others.