CYSTATIN C SERUM CONCENTRATION ALTERATIONS IN HEMORRHAGIC FEVER PATIENTS WITH RENAL SYNDROME
Early diagnostics of acute renal failure in hemorrhagic fever patients with renal syndrome (HFRS) is of great importance. The aim of our study was to examine the dynamics of a renal dysfunction marker cystatin C in different periods of HFRS and to detect its prognostic significance. We determined the serum level of cystatin C in 55 patients with moderate and severe disease. It was found that with moderate HFRS course, there was an increase in cystatin C serum concentrations in the oliguric period, and a decrease in cystatin C serum concentrations in the polyuric period. With severe course of disease, serum cystatin C level was shown to increase in the feverish period, to be the highest in the oliguric period and to decrease in the polyuric period, still remaining higher values compared to the control group.