Synthesis of 3,5-Disubstituted-1,2,4-oxadiazoles from Amidoximes and Aldehydes in Superbase NaOH/DMSO Medium
The article considers a new room temperature synthesis of 3,5-disubstituted-1,2,4-oxadiazoles, which consists in the interaction of amidoximes and aldehydes in a superbasic NaOH/DMSO medium. The thirteen different 3,5-disubstituted-1,2,4-oxadiazoles were obtained from amidoximes and aromatic aldehydes as examples with the moderate to good yields up to 76%. An attempt to synthesize 3,5-disubstituted-1,2,4-oxadiazoles from amidoximes and aliphatic aldehydes did not lead to the desired result.