PROINFLAMMATORY MECHANISMS OF NEUTROPHIL GRANULOCYTE DEATH
Neutrophil granulocytes play a central role in the innate nonspecific defense response of the human organism. They have a rapidly realizable, highly aggressive and bioactive factors (ability to produce excessive amounts of reactive oxygen and nitrogen species and a wide range of hydrolytic enzymes; cationic proteins; ability to produce cytokines, etc.). More than 10 mechanisms of cell death have been officially registered for them, including the unique formation of NET (neutrophil extracellular traps). Since neutrophil is the central part of exudative-destructive inflammation, the mechanism of its death can directly influence on the dialectic of inflammation either by helping to resolve inflammation and repair of damage, or, conversely, by increasing the effectors cascade and contributing to the development of flogogenic complications. Here it is discussed the mechanisms of neutrophil granulocytes death with proinflammatory activity.