CHANGES OF BLOOD LEUKOCYTE INDICES UNDER ACUTE EXPERIMENTAL CEREBRAL HYPOXIA IN RATS WITH DIFFERENT LEVELS OF STRESS RESISTANCE
The study features leukocyte reaction in the simulation of acute cerebral hypoxia in rats with different stress resistance. Bilateral ligation of common carotid arteries was used as a model of acute cerebral hypoxia total brain. The "open field" test and calculation of the index adaptation tensions by LH Garkavi were applied for assess of stress reactivity. We investigated the leukogram of peripheral blood. Staging adaptive compensatory reactions of white blood cells were diagnosed under the simulation of total acute cerebral hypoxia in rats. In the initial phase (mobilization) short leukocytosis, lymphopenia hypoeosinophilia with a decrease of the indices of adaptation tension and immunoreactivity occurred. The second phase (resistance) characterized by the activation of immune mechanisms reflecting the recovery processes in the blood system. The high stress resistance animals experienced a lower level of immune responses compared to animals with low stress tolerance.