Therapy of ventricular tachycardia paroxysms "Torsades-de-Pointes" in a patient with long QT syndrome developed as a result of antibacterial therapy
Acquired LQTS syndrome is a rather frequent and serious complication developing during oral cardiotherapy and oral therapy with drugs of many other pharmacological groups. The LQTS syndrome is a predictor of severe life-threatening arrhythmias, including the "Torsades-de-Pointes" ventricular tachycardia. Arrhythmias developing as a result of the long electric systole are often drug-resistant and require electrical cardioversion. A significant prolongation of the QT interval in 40-year-old female patient with undifferentiated leukemia developed under conditions of combined oral therapy with moxifloxacine and pentamidine and involved a series of ventricular tachycardia attacks of the "Torsades-de-Pointes" type. Discontinuation of the drugs, causing electric systole prolongation, and timely antiarrhythmic therapy led to normalization of the QT interval length and heart rhythm recovery without electric cardioversion.