STRUCTURAL AND FUNCTIONAL ORGANIZATION OF NEUTROPHILM MEMBRANES IN BRONCHOPULMONARY DISEASES AND CORRECTION OF THEM WITH ANTIOXIDANT PREPARATIONS
The article is devoted to the study of the effect of antioxidant preparations on the intensity of mitochondrial fluorescence of the potential-sensitive cation probe 4- (p-dimethylaminostyryl) -1-methylpyridinium (DSM) and lipid peroxidation (POL) activity in cells with bronchopulmonary diseases.The peculiarities of the action of drugs (dimephosphon and mexidol) on neutrophils in the development of antioxidant stress are considered. The most effective means of having a positive effect on neutrophils is dimephosphon. The drug increases the overall antioxidant activity and significantly inhibits the intensity of lipid peroxidation, resulting in the regeneration of the cell membrane apparatus.It has been shown that mexidol is an inhibitor of free-radical reactions taking place in neutrophils, changes the structural and functional state of membranes, lipid-protein interrelations, receptor functions and membrane-bound enzymes. Both drugs are membrane modulators that alter the structural and functional properties of neutrophil membranes.