CLINICAL DEATH ACTION AFTER ACUTE BLOOD LOSS ON UNSPECIFIC RESISTANCE AND CYTOKINES PRODUCTION IN EXPERIMENT
The purpose of the experimental investigation is to study of phagocyte condition and the level of proinflammation cytokines during 35 days after death blood loss. The experiment was carried out on 210 non-inbreeding white rats weight 190-220 g using anesthesia of ketamin (2 mg/kg). The disorders in system phagocyte ware observed in all period of experiment. It was expressed by increase phagocyte number and by changes phagocyte index. Cell reaction ware developed by neutrophilic leukocytosis in early period and ware developed by monocytosis in late one. Stabile increased content of proinflammation cytokine (TNF-а) was observed during all period experiment and was attendant by changes phagocyte activity in blood.