Clinical and immunological evaluation of the effectiveness of balneotherapy in combination with alflutop in osteoarthritis
Pathogenetic basis for the effectiveness of balneotherapy was evaluated by the study of pro-and antiinflammatory cytokines in 93 patients with osteoarthritis (OA) in sanatorium "Yakty-Kul". The increase in the initial level of pro- and anti-inflammatory cytokines was revealed, which corresponded to high intensiveness of pain, articular index and activity of inflammation. The positive dynamics of the articular and pain index as well as the index of activity of inflammation in OA patients received balneotherapy was associated with a decrease in the synthesis of pro-inflammatory cytokine TNFα and a moderate decrease in the level of IFNγ and anti-inflammatory cytokine IL-4. The data indicate the advantage of combined therapy (balneotherapy with alflutop injections) in reduction of inflammatory cytokines TNFα and IFNγ