HARMLESS USE STUDY OF MICRO – AND NANOSIZED PARTICLES BASED ON (METH)ACRYLIC COPOLYMERS AS TARGETING ORAL DRUG DELIVERY SYSTEMS IN SITE-SPECIFIC GASTRO-INTESTINAL REGIONS
The study of harmless use of micro- and nanosized particles of interpolyelectrolyte complex (IPEC) using oppositely charged brands of (meth)acrylic copolymers Eudragit® has been carried out on mice in order to develop potential carriers for oral delivery systems. The results of experiment has shown no toxic effects and action on central nervous system of micro- and nanosized compositions when administered orally to the experimental animals in the maximal dose of 3000 mg/kg.Recent studies demonstrate perspective direction indicating that micro- and nanosized forms of IPEC using copolymers Eudragit® may be safe for use as carriers of drug substances for their targeted delivery to specific regions of the gastrointestinal tract.