INACTIVATION OF INFECTIVITY OF HISTOPLASMA FARCIMINOSUM FUNGUS
This article presents the results of the selection of inactivants for a vaccine against equine lymphangoitis. Various inactivants such as DEI (N,N-dimethylethylenediamine), beta-PROPIOLACTONE, formaldehyde, alcohol, glutax and anolyte were used to work out the parameters of inactivation of the Histoplasma farciminosum fungus. At the same time, the optimal final concentration of beta-PROPIOLACTONE inactivant 0.5%, the temperature of the reaction medium (22 ± 3.0) 0C, pH 7.4-7.6, the duration of inactivation 600 min. were also established.