Genes of the antioxidant system and pathology of the eye
Oxidative stress plays a key role in the origin, development and clinical course of many widespread ophthalmic diseases. Molecular mechanisms of its pathogenesis are associated with antioxidant system dysfunction and damaging activity of free radicals and have a genetic basis. This article provides a comprehensive review of the current knowledge pertaining to the role of antioxidant gene polymorphism in etiopathogenesis of cataract, glaucoma, age-related macular degeneration and several other ocular diseases.