Molecular and genetic mechanisms of development of coronary heart disease (review)
Coronary heart disease (CHD) occupies a leading place in the world among the causes of death, and myocardial infarction (MI) often leads to disability and incapacity for work. The main pathogenic mechanism of the develop-ment of the disease is atherosclerotic changes occuring in the coronary arteries and progressing with age. In recent years, there are more and more patients developing MI at a young age, that allows us to speak about both genetic factors causing early vascular aging and epigenetic mechanisms of early vascular inflammation under the influence of environmental factors. However, there is no unequivocal opinion on this issue. The review is devoted to the importance of conducting molecular genetic studies to identify the risk groups for the early development of coronary artery disease, as well as understanding the genetic and epigenetic mechanisms of its development.