Efficacy of Amizonchik in complex treatment of acute viral respiratory tract infections in children
Acute viral respiratory tract infections are the most common reason for seeking medical attention and their course in young children is often associated with development of complications. The treatment efficacy of acute viral respiratory tract infections can be improved by learning of their pathogenesis and immunity that results in elimination of the causative agent. To study the efficacy of complex treatment of acute viral respiratory tract infections in children with administration of Amizonchik according to evaluation of clinical and laboratory parameters in different periods of the disease. We observed 74 3–12 year old children with moderate course of acute viral respiratory infections. Parainfluenza viral antigens, adenovirus, respiratory syncytial virus or rhinovirus were identifi ed in nasopharyngeal swabs of the patients. The fi rst group (study group) included 38 patients who were treated by administration of Amizonchik. The second group (comparison group) included 20 children treated by other anti-viral drugs. The third group (control group) included 16 children who received only symptomatic therapy. The administration of Amizonchik results in early normalization of body temperature, the involution of catarrhal symptoms and significant increase in CD4 + and CD16 + -cells and has favorably effect on the dynamics of cytokine levels and IgA and lysozyme levels in oropharyngeal secretions comparing with the control group. The administration of Amizonchik in children with acute viral respiratory tract infections has a positive effect on the regression of clinical manifestations, shortens the duration of the febrile period and catarrhal symptoms, normalizes the parameters of total blood analysis in those patients. The administration of Amizonchik in children with acute viral respiratory tract infections contributes to the rapid restoration of cytokine profile and lymphocyte -macrophage cell cluster rate, normalizes the local protective factors – sIgA and lysozyme in oropharyngeal secretion. Addition of Amizonchik to complex therapy of acute viral respiratory tract infections in children helps to avoid polypragmasy, including the administraion of antipyretics. The administration of Amizonchik is a promising direction in treatment of children with acute viral respiratory tract infections.