Significance of expression of molecular markers in diagnostics of precancerous lesions and transformations of gastric mucosa
Introduction. Gastric cancer is a global problem for the health systems worldwide. Today it takes the fourth place in the world in the morbidity and the second place in the mortality structure. In Russian Federation, almost 70% of gastric cancer cases are diagnosed at III-IV stage of the pathological process that leads to unsatisfactory results of treatment and poor prognosis. This situation determines the need for early diagnostics of gastric cancer at the stage of precancerous conditions and transformations of gastric mucosa. The aim is given to studying carcinogenesis, particularly in patients with precancerous pathology. Aim of this review was an invertigation of molecular markers of gastric cancer and its expression in precancerous conditions. Methods. Overview of acticles dedicated to molecular markers of gastric cancer was done. Results. Such an approach is an important aspect not only in diagnostics but also in the management of oncological diseases because the most of identified molecules involved into the transformation are the targets for anticancer therapy. Conclusion. There is a wide spectrum of studies dedicated to molecular mechanisms of cancerous lesions. But at the same time, molecular markers expression in precancerous conditions and lesions requires further investigation.