Significance of prognostic factors in chronic lymphocytic leukemia before and during treatment
The review presents modern data on the prevalence of chronic lymphocytic leukemia (CLL) and pathogenetic aspects of its course. There are described the long-known and new prognostic factors in CLL, including cytogenetic, molecular-genetic, immunophenotypic markers of prognosis, determination of drug sensitivity of tumor lymphocytes to chemotherapy drugs. The factors are considered both before the treatment and in the process of it. The peculiarities of modern treatment and the ways of its improvement are outlined on the base of the prognosis of the course of CLL.