The role of bone scintigraphy in detection of bone metastases of prostate cancer in patients with biochemical recurrence after radical prostatectomy
Objective: to evaluate the relationship between serum PSA and other variables to eliminate bone scanning (BS) in patients with biochemica l recurrence (BR) after radical prostatectomy (RP) having a low probability of bone metastasis. Material and methods. The study included 110 patients with BR after RPE between 2008 and 2012. Bone metastasis was studied for its cor relation with various clinical and pathological variables in these patients. Results. According to multivariate regression analysis the trigger PSA level, PSA doubling time and Gleason sum were independent predictor s of detecting of bone metastases using scintigraphy. The frequency of bone metastases was 0 % (95% CI 0,0 − 14,3) in patients with PSA  5 ng/mL, PSA doubling time  6 month and Gleason sum after RP  6. Conclusion. For patients with trigger PSA levels of 5 ng/ml or lower, PSA doubling time 6 month or less and Gleason sum 6 or less, BS may b e eliminated because of the negligible risk of bone metastases.