The growth in children with diabetes mellitus type I: the influence factors
The article discusses the mechanisms of influence of uncompensated course of diabetes mellitus type I on mineralization of skeleton and growth of child. the objective. The evaluate the level of mineralization of skeleton bones and risk factors of decreasing of growth rate in children with diabetes mellitus type I. materials and methods. The sampling included 82 children aged from 8 to 15 years with diabetes mellitus type I. The duration of disease consisted 3,1±2.6 years. Out of all examined children, 9% were of school age and 91% were of pre-puberty and puberty age. The anthropometric parameters (body height and body mass) were measured. The degree of decompensation of diabetes mellitus type I was detected by level of glycosylated hemoglobin in blood using the analyzer D-10, BIO-RAD ( USA). The calcium supply was evaluated by the level of total and ionized calcium, parathyroid hormone. The activity of bone remodeling was established by level of osteocalcin as marker of bone formation. The vitamin D supply was evaluated by concentration of hydroxivitamin D in blood plasma the device “Lazuritis”, D-1; BOI-RAD (USA). The mineral bone density of lumbar vertebrae and composite structure of body (content of bone mineral, fat mass and lean mass) were detected by X-Ray densitometry technique using densitometer Discovery A (Hologic, USA) using standard program and applying option “whole body”. The level of vitamin D<20 ng/ml was considered as clinically significant decreasing and level higher than 30 ng/ ml as an acceptable one. The statistical processing was carried out using software “Statistica v.7.0”. results and discussion. It is established that in children with uncompensated diabetes mellitus type I the indicators of growth and mineralization of cortical bone are below age standard. conclusion. The decompensation of diabetes mellitus in children negatively impacts rates of skeleton growth and mineralization of child that is conditioned by hyperglycemia. The alterations are more often registered against the background of vitamin D inadequate supply in child.