THE ROLE OF ENDOTHELIN-1 (LYS198ASN) GENE POLYMORPHISM IN PATIENTS WITH ACUTE SCHIZOPHRENIA AND ALCOHOL DELIRIUM IN A COMPARATIVE ASPECT
The aim of the research:study the frequency of genotypes and alleles of polymorphism of genes Endothelin-1 (Lys198Asn) in patients with a psychotic state with a paranoid form of schizophrenia and with alcohol withdrawal syndrome with delirium. Materials and methods. 100 patients with paranoid schizophrenia (F 20.09), 91 patients with alcohol withdrawal syndrome complicated by delirium (F10.40), 100 patients with a history of alcohol dependence syndrome without a history of psychosis (F 10.2x2) were examined. The control group consisted of 102 healthy people. An allele-specific polymerase chain reaction method was used to study SNP END-1 (Lys198Asn). Results. Patients with schizophrenia were 1,8 times more likely to have carriers of the mutant allele Asn SNP END-1 (Lys198Asn), in which the risk of developing the disease was 2,5 times higher. Among the examined patients with alcoholic delirium, in comparison with patients with an alcoholism without a history of psychosis, carriers of the allele Asn of this polymorphism were also recorded 1,5 times more often, for which the risk of psychosis was determined with an increase of 1,73 times. A comparative analysis between individuals with schizophrenia and withdrawal symptoms with delirium showed a more significant significance of SNP Endothelin-1 in schizophrenia. Conclusion. The data obtained by us demonstrate the possible role of genetic defects of Endothelin-1 in the mechanisms of development of psychotic disorders with in schizophrenia and alcoholic delirium.