DIFFICULTIES OF DIFFERENTIAL DIAGNOSIS OF SLOW VIRUS INFECTION: CLINICAL CASE SUBACUTE SCLEROSING PANENCEPHALITIS
A clinical case of a 4-year-old child with subacute sclerosing panencephalitis is presented. The diagnosis was confirmed by clinical symptoms, the results of magnetic resonance imaging of the brain, electroencephalography, blood and cerebrospinal fluid studies. On brain MRI signs of diffuse lesions of the white matter of the cerebral hemispheres of the brain, the basal nuclei, Pons, middle legs of cerebellum with cytotoxic edema. It should be noted that computed tomography revealed no changes during the year from the beginning of clinical manifestations. On electroencephalography revealed periodic pathological activity with high-amplitude tetta waves, rarely Delta waves, mainly on the left.The cerebrospinal fluid is elevated in the antibody virus. Detection of IgM antibodies does not play the role of diagnostic studies, as an increase in their titer is noted in less than 10% of cases. The introduction of anti-measles vaccination reduces the incidence of sclerosing panencephalitis by 90%.