The benzodiazepine problem: what does the experience with tofisopam (grandaxin) tell us about?
The article reviews current aspects and history of benzodi- azepine use, the reasons for their limited use, their role in the treatment of anxiety disorders. Potential side effects are ana- lyzed in detail and the necessity of controlled use of benzodi- azepines is emphasized. The authors present the results of their study on the use of tofisopam for chronic anxiety syndrome in general practice, with convincing evidence that there is no with- drawal syndrome after a 3-months treatment course