Clinical efficacy of immunotherapy in complex treatment of patients with acute optic neuritis associated with herpesvirus infection
The purpose of the research was to study the clinical effectiveness of the system of complex treatment of optic neuritis (ON) associated with herpesvirus infection (HVI). The clinical study involved 55 people (55 eyes) with acute ON associated with HVI. The treatment regimen for all patients included 10 days the addition of Dexamethasone solution to optic nerve on decreasing scheme, Emoxypine 1 % 0.5 ml and Dicynone 12.5 % 0.5 ml through irrigation system implanted in retrobulbar space, in combination with appoint of neuroprotective drugs (Picamilon and Semax). Depending on features of immunotherapy, all patients were divided into 3 groups. The duration of immunotherapy was 10-12 days. The analysis of obtained data showed that more significant positive dynamics was noted in the clinical course of ON in patients of the 3rd group of observation, who simultaneously received complex of 3 immunotropic drugs. The method of etiotropic and pathogenetic immunotherapy developed by us, represented by the combination of Polyoxidonium, Cycloferon and Derinat, at ON, associated with HVI, allows to shorten by 2 times or more the period of stopping of signs of inflammation in optic nerve, to exceed the average visual acuity in the period of clinical recovery by 0.5-1.3 times and improve functional results of treatment in the absence of recurrence of the disease within 1 year of observation.