RESEARCH ON DEVELOPMENT OF DRUG SYRUPS
The article is aimed at the development of new methodological approaches in the construction of drug syrups and their practical application. The authors of the paper have studied Russian and foreign regulatory documents regulating the development and evaluation of the syrups quality as the dosage form. New methodological approaches in the development of syrups are developed. The methodology has been used in the development of desloratadine syrup, the elaboration of which is very relevant, in the absence of a given dosage form in the domestic pharmaceutical market. On the basis of literature data, the composition of antihistamine syrup using auxiliary substances that provide optimal technological and physico-chemical properties of the dosage form has been matched. The assessment of quality and stability of this dosage form was carried out in accordance with the requirements of the world leading pharmacopoeias. Quantitative determination of desloratadine in the syrup was determined using the HPLC method developed by the authors.