Experimental grounds for possibilities of improving antibacterial therapy of infectious complications in surgery
The combined use of Perftoran and antibiotic drugs Lincomycin, Tsiprolet, and Cefotaxime on the level of their minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was produced “in vitro” in order to study the synergistic effect. The method of agar dilution with the collection strains Staphylococcus aureus ATCC 25923, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Proteus vulgaris ATCC 4636, and Candida albicans NCTC 2625 was used. It was found, that Perftoran does not have an antibacterial effect with respect to the test strains. The combined introduction of Perftoran and antibiotic drugs into a nutrient medium reduces MIC and MBC. This effect is the highest when combining Perftoran with Cefotaxime - MIC decreased 8-32 times, MBC - 4-64 times. This effect was also observed in relation to individual cultures but not more than 2-4 times. The observed effect is due to the entry of facultative anaerobes into the vegetative phase, which reduces their resistance to the action of antibiotics.