THE EFFECT OF LOCAL THERAPY OF APPLICATIONS OF XYDIPHONE ON THE OUTCOME OF THE DISEASE AND QUALITY OF LIFE IN PATIENTS WITH OSTEOARTHRITIS
Objectives. To study the effectiveness of applications of xydiphone on the dynamics of indicators of quality of life and the outcome of the disease in patients with osteoarthritis. Materials and methods. The randomized open, comparative in parallel groups, with active control study included 60 patients with osteoarthritis of the knee II-III-V stage, pain when moving more than 40 mm in Your and Leken index more than 9 points. 30 patients were treated with xidiphone applications during the 30-day follow-up period and 30 patients in the comparison group received oral diclofenac treatment during the same period. The dynamics of pain during movement and at rest according to Your womac index, the overall assessment of the effectiveness of therapy by the patient and the doctor, the quality of life (QL) was evaluated on the scale of well-being EQ-5Dvas, the effectiveness of OMERACT-OARSI and the need for NSAIDs. Results. The OMERACT-OARSI TEST showed a high response rate to therapy, a statistically significant decrease in the intensity of pain during movement and at rest was demonstrated by all patients of the group of applications of xydiphone and the comparison group and amounted to 70-71% in both groups . A statistically significant decrease in the index was obtained by calculating the total score of WOMAC, as well as on the scales of "pain", "stiffness" and "function" in both research groups P<0.01. No statistically significant difference between the study groups was obtained P> 0.05. QOL was significantly increased on the EQ-5D vs well-being scale in the main group and comparison group P< 0.05, in the ab- sence of statistically significant differences between the main group and comparison group P> 0.05. Conclusion. The obtained data of the conducted scientific study on the criteria for evaluating the effectiveness of OMERACT-OARSI allow us to talk about the comparability of the method of treatment with applications of xidiphone NSAIDs on the effect on the total indicators of the WOMAC index and on the indicators of "pain", "stiffness" and "function" in patients with OA.