The influence of melatonin on stress-induced changes in the periodontium of rats with different typological features
Chronic stress is accompanied with significant morphological and biochemical disorders in the parodontium tissue of stress-nonresistant rats, including the decrease of thickness and dystrophy of epithelium, the edema of lamina proper, the decrease of thickness of bone trabecules, as well as the decrease of collagen and glycosaminoglycans content, lipid peroxidation activation and the diminution of catalase activity in gum tissue. The expression of morphological changes and the increase of malonic dialdehyde and acylhydroperoxides content were less in stress-resistant rats in comparison with stress-nonresistant ones. The melatonin injections decrease the stress-induced changes in parodontium of the rats of both groups. The effects of hormone are more expressed after its administration in the dose 1 mg/kg.