INVOLVEMENT OF THE γ-GLOBULIN METAL COMPLEXES IN REGULATION OF THE INTERLEUKIN-10 PRODUCTION
It is shown in the work, that in common cytokine pool induced in the culture of human peripheral blood cells (PBC) in presence of the γ-globulin fraction proteins and of their metal complexes, production of interleukin-10 (IL-10) has been detected. Production of IL-10 in presence of γ-globulin complexes with copper was higher than in presence of their control proteins or copper ions used alone at 24 and 72 hrs of observation. Production of IL-10 in presence of γ-globulin complexes with zinc was higher than in presence of their control proteins or zinc ions used alone at 48 and 72 hrs of the PBC incubation. Production of IFN by PBC could also be detected. There was a high correlation between IFN and IL-10 production by the cells induced with γ-globulin metal complexes. Possibility for regulation by the γ-globulin metal complexes of IL-10 production at the level of basal PBC functions was discussed in a context of Th2 polarization of the immune response.