Genomic and epigenomic determinants of atherosclerosis in male military personnel
The modern medical community is actively discussing predicting and preventing multifactorial diseases, such as atherosclerosis, metabolic syndrome, and oncopathology. Almost every significant risk factor in humans has a specific genetic determination. Statistics show that 12% of the population has a burdened family history of cardiovascular disease. In research on the human genome study, special attention is paid to single - nucleotide polymorphisms and associated mutations, leading to the development of diseases of the circulatory system. The article presents population frequencies, phenotypes, and the results of our studies of genetic polymorphisms of several relevant genes associated with the development of atherosclerosis, obesity, leptin resistance, arterial hypertension, and type 2 diabetes mellitus. The modern views on epigenetic heredity are presented on the example of methylation of deoxyribonucleic acid, its influence on the genome, and phenotypic manifestations of atherosclerosis.