Clinical efficacy and side effects of statins: contemporary insight on the problem
This review focuses on the clinical efficacy, pharmacogenetics, the need for effective and affordable choice of drugs of the statin that provide a positive lipid-lowering and pleiotropic effects and to avoid dangerous side effects. It was also found that in some polymorphic variants of the gene lipoprotein lipase, regression of coronary artery disease on statin therapy background was observed. Lack of effect of statins on high-density lipoprotein observed in patients with type 2 diabetes, with the polymorphic variants of the gene transfer protein cholesterol ester. Carriers of the mutant allele of this gene is also characterized by less effect of statins on mortality reduction.