Clinico-pathomorphological studyof myelofibrosis in multiple myeloma
Pathomorphology study of bone marrow fibrosis in patients with multiple myeloma by using morphometric image analysis software was performed. It was revealed that bone marrow fibrosis occurs 1.5 times more frequently in relapse of disease than in the initial presentation of the disease and in response to chemotherapy. The highest relative area of fibrous tissue in marrow fibrosis of 2nd and 3rd grade is observed in relapsed multiple myeloma. There is a direct correlation between the relative area of the tumor tissue in the bone marrow and the relative area of fibrous tissue in bone marrow fibrosis of the 1st and the 2nd grade. Chemotherapy is a factor associated with bone marrow fibrosis of the 2nd and the 3rd grade. Gender and age of the patients are not associated with marrow fibrosis.