An effect of the polymorphism of interleukin-1B -511 T/C gene on the development and course of chronic Helicobacter pylori-associated pathology of the gastroduodenal area in children
The objective. To determine an effect of the polymorphism of interleukin-1B (IL1B) -511 Т/С gene on the development and course of chronic Helicobacter pylori (H.pylori)-associated pathology of the gastroduodenal area in children. Patients and methods. The examination included 96 patients with H.pylori-associated pathology of the gastroduodenal area aged from 7 to 17 years: 81 children with chronic gastroduodenitis (CGD) and 15 children with duodenal ulcer (DU). Results. Analysis of the findings did not determine any significant differences in the frequency of С- and Т-alleles of IL1B gene in children with chronic H.pylori-associated pathology of the gastroduodenal area. However, a mutant Т-allele was detected in more than half of the patients with CGD and DU (64.2 и 80%, respectively). The mutant homozygote genotype Т/Т (15 and 2.8%) and the highly productive Т-allele (78.3 and 47.2%, respectively) (p < 0.05) were detected in children with marked pain and abdominal syndromes more often than in patients with obscure symptoms. In children with moderate disease syndromes, in contrast to patients with a marked clinical picture, the normal С/С genotype (52.8 and 21.7%) and С-allele (97.2 and 85%, respectively) were found more often (p < 0.05). As has been shown, patients with a mutant Т-allele of IL1B gene are subject to development of intestinal metaplasia in chronic H.pylori-associated gastroduodenal pathology. Conclusion. The study has demonstrated that IL1B -511 Т/С gene polymorphism has an effect on not only specificities of the course and manifestations of chronic H.pylori-associated gastroduodenal pathology, but also on the character of lesions of the mucous membranes of the gastroduodenal area in children.