The effectiveness of the use of adjuvant and immunomodulatory drugs for immunization of animals with rabies virus
The article presents the comparative results of the use of immunomodulatory preparations Immunofan and Polyoxidonium and an adjuvant based on synthetic oil PES-300 with lanolin during the immunization of sheep with purified inactivated rabies virus. The effect of increasing the level of specific antibodies in immunized animals significantly increases with the combined use of these immunomodulators with rabies virus and oil adjuvant. The advantages of the Imunofan preparation are shown, the introduction of which with rabies virus emulsified virus ensured the formation of a higher level of rabies immunity. The combined use of rabies virus with oil adjuvant and Immunofan can be recommended for obtaining anti-rabies serum, as a component of diagnostic test systems.