NEW POLYMER MATERIAL BASED ON mimetics OF natural nitric oxide (NO) donors
Homogeneous water-soluble polyvinylpyrrolidone composites containing nitric oxide donors - cationic dinitrosyl iron complexes with antitumor and antiseptic activity have been obtained in the first time. Their morphology in the solid state was studied by X-ray diffraction and scanning electron microscopy. Small-angle diffraction method demonstrated that in samples lacking aggregates of the composites of 10-100 nm, and iron nitrosyl complexes are uniformly distributed in the polymer matrix. EPR method defined content in composites cationic dinitrosyl iron complexes capable of generating NO. Amperometry methods found that polymer materials decompose to NO within seconds after being dissolved in an aqueous solution without photo- and thermal activation. In this work NO levels of all film samples at pH 7.0 were determined. Polymer composites have properties of the original bulk iron-sulfur nitrosyl complexes and can be used as NO delivery systems for biomedical application.