PROLIFERATION OF SKIN CELLS WITH INTRADERMAL ADMINISTRATION OF HYALURONIC ACID TO EXPERIMENTAL ANIMALS
The paper presents the results of studying the proliferation markers of the fibroblast-1 growth factor Ki-67 (FGF-1) in the skin of female rats of mature age (11-12 months) with intradermal mesotherapy with the preparation of native high-molecular hyaluronic acid (mol. Yes) immunohistochemical method using mouse polyclonal antibodies. It was found that hyaluronic acid stimulates the proliferation of fibroblasts, skin epithelial cells and hair follicles, and vascular endothelium. The maximum expression of the Ki-67 protein in this case occurs on the 7th day after the injection of hyaluronic acid, and FGF-1 on the 21st day.