FEATURES OF TUBERCULOSIS ASSOCIATED WITH HIV INFECTION AND VIRAL HEPATITIS
Aktual'nost'. Tuberkulez yavlyayetsya shiroko rasprostranennym infektsionnym zabolevaniyem, kotoryy chasto assotsiirovan s virusnymi gepatitami i VICH infektsiyey. Tsel'. Otsenit' vliyaniye razlichnykh sochetaniy koinfektsiy (TB+VICH+VG), (TB+VICH), (TB+VG) na klinicheskoye proyavleniye tuberkuleza. Metody. Byla izuchena i sistematizirovana rossiyskaya i zarubezhnaya literatura, a tak zhe proanalizirovany issledovaniya na predstavlennuyu temu za posledniye 5 let. Rezul'taty. Primeneniye kompleksnogo lecheniya protivotuberkuleznymi i ARVT u bol'nykh (VICH+TB±VG) ne soprovozhdayetsya razvitiyem gepatotoksicheskikh reaktsiy. U bol'nykh v gruppe (TB+VICH+VG) soderzhaniye gamma- globulina okazalos' znachitel'no vyshe, chem u bol'nykh drugikh grupp (TB;TB+VICH;TB+VG). Na rannikh stadiyakh VICH infektsiya proyavlyayetsya vovlecheniyem v vospalitel'nyy protsess vnutrigrudnykh limfaticheskikh uzlov (VGLU). Techeniye TB na pozdnikh stadiyakh VICH-infektsii imeyet sklonnost' k generalizatsii protsessa s porazheniyem ne tol'ko organov dykhaniya, no i drugikh sistem organizma. Zaklyucheniye. Neobkhodimy dopolnitel'nyye mery dlya optimizatsii profilaktiki, vyyavleniya i lecheniya tuberkuleza, assotsirovanogo s VICH- infektsiyey i virusnym gepatitom. Ещё 1161 / 5000 Результаты перевода Relevance. Tuberculosis is a widespread infectious disease that is often associated with viral hepatitis and HIV infection. Goal. To assess the impact of various combinations of coinfections (TB + HIV + GV), (TB + HIV), (TB + GV) on the clinical manifestation of tuberculosis. Methods. Russian and foreign literature was studied and systematized, as well as studies on the topic presented over the past 5 years were analyzed. Results. The use of complex treatment with anti-tuberculosis and ARVT in patients (HIV + TB ± GV) is not accompanied by the development of hepatotoxic reactions. In patients in the group (TB + HIV + VH), the content of gamma globulin was significantly higher than in patients in other groups (TB; TB + HIV; TB + VH). In the early stages of HIV infection is manifested by involvement in the inflammatory process of the intrathoracic lymph nodes (IHLN). The course of TB in the late stages of HIV infection tends to generalize the process, affecting not only the respiratory system, but also other body systems. Conclusion. Additional measures are needed to optimize the prevention, detection and treatment of tuberculosis associated with HIV and viral hepatitis.