CLINICAL AND EPIDEMIOLOGICAL FEATURES OF THE COURSE OF VIRAL HEPATITIS A IN CHILDREN IN THE VORONEZH REGION
Viral hepatitis A (HAV) is still the most common liver disease in humans. Objective: in this study, we analyze the clinical and laboratory features of the course of HAV in children in Voronezh and the Voronezh region for the period from 2019 to 2020. Methods: we analyzed 44 medical records of children diagnosed with acute HAV. The average age of the patients was 8.1±3.9 years. The diagnosis was established on the basis of clinical and laboratory studies conducted in accordance with the International Classification of Diseases of the tenth revision. In all patients, anti-HAV IgM was detected in the blood by enzyme immunoassay. Results: in most patients, the disease was mild to moderate in severity. The pre-jaundice period in 78.5% of patients was mixed. The duration of the symptoms of intoxication was significantly different: in patients with mild HAV, it was 7.5±4.2 days, moderate 11.9±4.7 and severe 19.4±6.4 days. In most patients, the level of total bilirubin was 2.5 times higher than normal. The cytolysis parameters were increased by 6 times compared to the normal values. The symptom of cholestasis was detected in 100% of patients. Biochemical parameters of cholestasis were 2 times higher than normal. Conclusions: HAV remains an urgent public health problem to date. The clinical picture is dominated by the cholestatic symptom.