Modern trends in the studies of ABC transporters associated with multidrug resistance phenomenon and of their role in lymphocytes
The authors have reviewed current tendencies in the investigation of the transporters of ABC superfamily. Their biological function, cellular localization and structural organization have been under study. Transport mechanism for substrates has been described on the model of bacterial protein Sav1866 and mice P-glycoprotein. Special attention has been attracted to the expression, activity and physiological role of ABC transporters associated with multidrug resistance phenomenon in human lymphocytes. Regulation data through redox-mediated mechanism for conformation and functional activity of protein-transporters has been discussed as well.