An evaluation of the efficacy and safety of Mifepristone for preinduction and induction of labor
The authors studied the efficacy of Mifepristone for preparing the uterine cervix and induction of labor by obstetric indications. Data referring to the course of pregnancy, labor and perinatal outcomes in 60 women with full-term pregnancy at term 38-40 weeks were analyzed. The basic group comprised 30 patients who received mifepristone for preparing the cervix with further labor induction, the control group had 30 women whose preparation was carried out according to the standard scheme. It was established that at the background of administration of mifepristone the average period of preparation of the birth canal became shorter (2.8 ± 0.3 days in the group of study vs. 6.4 ± 0.7 days in the control group), the efficacy of subsequent introduction of prostaglandins with respect to development of regulatory labor activity enhanced; signs of increasing fetoplacental insufficiency were absent. The use of mifepristone for preinduction and induction of labor is an effective modern and pathogenetically justified method that can be regarded as a way to decrease perinatal morbidity and mortality