Characteristics distribution of HLA specificities of patients with myelodysplastic syndrome
The aim of this study was to investigate the rate of frequency of HLA (Human Leukocyte Antigens) class I (HLA-A, B, C) and class II (HLA-DRB1, DQB1) in a Kazakh MDS patients. For the study, 3621 healthy blood donors (control group) and 44 MDS patients (main group) were chosen. HLA-typing (HLA-A, B, C, DRB1, DQB1) of both groups was performed by polymerase chain reaction. HLA-B * 35, HLA-DRB1 * 11, *15 are associated with MDS. Phenotypes with the HLA-A * 02, HLA-C * 07 antigens have a protective effect regarding the development of MDS.