Histological, histochemical, ultrastructural and morphometric analysis of intima in rabbit aorta during cholesterol loading
The results of experimental studies of the cholesterol loading effect on the atherogenic lesions intima formation in rabbit aorta are presented in the article. Endothelial cell activation, apoptosis and increased desquamation were discovered at the stage of initiation and early stages (1-7 days) of experimental atherogenesis; compensatory reaction (endothelial cells (EC) conglomerates, tendency to intimal hyperplasia increase was traced during the most intense apoptosis EC) was observed on 7-15 days of atherosclerotic lesions formation; decrease of EC apoptotic index due to the transition of the late stage of apoptosis to necrosis was determined after 30-60 days of experiment.