THE EFFECT OF FLAVONOIDS EXTRACTS ON THE DIOKSIDINS INDUCTION OF MICRONUCLEI IN RED BLOOD CELLS OUTBRED WHITE MICE
The antimutagenic properties flavonoids extracts of three plants - Gratiola officinalis L., Helichrysum arenarium L. and Zеа mays L. anthocyanin form was investigated. The analysis was made by counting micronuclei in peripheral blood erythrocytes outbred white mice; mutagen was dioxidine. The extracts of Gratiola officinalis L. and Helichrysum arenarium L. not have mutagenic effect. The number of erythrocytes with micronuclei was observed only in the first day of the experiment under the action of the extract of Zеа mays L. The protector effect of extracts depends on the mode of them introduction. The greatest protector effect of the extract of Gratiola officinalis L. is observed already after one day after the introduction and dropped to fifth days of the experiment. Extract of Helichrysum arenarium L. reliable reduces the number of cells with disabilities, as on the first day, and on the fifth day of the experiment. The extract of Zеа mays L. has protector effect only on the fifth day after its introduction. Apparently, chemical compounds of extracts can reduce the number of free radicals in the cells by binding to them.