Stress reaction and biochemical shock as interrelated and unavoidable components in the formation of high radioresistance of the body by acute hypoxia
Stress-reaction with the activation of sympathetic-adrenal system by acute hypoxia reflects the degree of sensitivity of the body to the extreme. SDH activation in cells as adaptive responses to acute hypoxia is closely associated with the degree of violation of tissue respiration through the lack of oxygen in the tissues, including manifestation of “biochemical shock”, which is unavoidable component of implementation of protective effect of radioprotectors. In experiments on mice, rats and dogs correlation between the manifestation of radioprotecive effect of acute hypoxia and SDH activation in blood lymphocytes caused by mainly adrenergic stimulation during stress reactions is confirmed. The degree of SDH activation in blood lymphocytes by hypoxia of different genesis including that induced by radioprotectors may indicate its radioprotective potential being irrespective from differences in intensity of oxygen consumption and resistance to acute hypoxia in animals and humans.