THE APPLICATION OF THE EXTRACT FROM <i>HALOCYNTHIA AURANTIUM </i>AT RADIATION EXPOSURE
It was carried out the examination of the therapeutic effect of the extract from the marine hydrobiont Halocynthia aurantium (EA) under radiation impact. EA contains a complex of biologically active substances and had the ability to increase the nonspecific resistance of the organism to a number of extreme damaging factors. The object of the study was BALB/c mice (80 animals) subjected to γ-irradiation with low-power radiation at dose of 5 Gr. The estimate of EA effect on the post-radiation dynamics of peripheral blood parameters (leukocytes, platelets), bone marrow cellularity (femur) was the purpose of this work. EA were given to animals orally (from 1 to 13 day) starting after irradiation at the dose corresponding to 80 mg/kg of total lipids. The methods of taking the material and analyzing the elements of peripheral blood and bone marrow were standard. There was a sharp decrease in the total number of peripheral blood leukocytes and nucleated cells in the bone marrow observed: these values were within 20% of the level of intact animals (in booth group) on 3rd day after irradiation. EA application at mice against this background had positive effect on the restoration of the cellular structure of the bone marrow and promoted an increase the total number of peripheral blood parameters earlier, then in the control group. It can be concluded that the use of EA after radiation exposure has significantly increased the likelihood of a favorable outcome of acute radiation sickness and facilitate its course.