Changes in left ventricular function after treatment with dipeptidylpeptidase 4 inhibitor in type 2 diabetic patients
Aim. To study the effect of vildagliptin on left ventricular function in type 2 diabetic patients.Material and methods. 36 patients with 2 types diabetes and coronary artery disease were enrolled in randomized study. They were randomly distributed into three groups and treated with vildagliptin, vildagliptin + metformin or met- formin for 24 weeks.34 КЛИНИЧЕСКАЯ ФАРМАКОЛОГИЯ И ТЕРАПИЯ, 2011, 20 (5)papers5:Layout 1 11/13/11 2:55 PM Page 35ОРИГИНАЛЬНЫЕ СТАТЬИResults. Short-term treatment with vildagliptin improved the systolic and diastolic volumes of left ventricle andincreased tolerance to physical exertion.Conclusion. Vildagliptin improved left ventricular functionprobably via increase in myocardial metabolism and funcion ofhibernated cardiomyocytes.