EFFECT OF ACUTE HYPOXIA ON THE ANTIOXIDANT ACTIVITY OF HEPATIC TISSUE IN RATS WITH DIFFERENT RESISTANCE TO OXYGEN DEFICIENCY
Experiments were carried out in the autumn-winter period on rats male Wistar weighing 120-180g., which were divided into groups of highly stable and low resistant to hypoxia in rats. As the models were used the acute hypobaric hypoxia, heat ischemia. Th e condition of antioxidative reserves has ben estimated by the increase of TBA-active products, the content of -tocopherol and restoration of free radical -diphenil--pikrilgidrazil. Th e experiments on rats have shown that the liver tissue of rats low resistant to hypoxia, compared with tissue of high resistant animals has lesser antiradical and antioxidant reserve. Th e most distinct diff erences in antioxidant status in animals with diff erent resistance to hypoxia were observed in conditions of hypoxic and thermal induction of lipid peroxidation. In adaptation of the rats to hypoxia, diff erences in the antioxidant status of the individuals of diff erent phenotype smooth over.