DYSFUNCTION FINAL STAGE OF BLOOD COAGULATION IN CHILDREN WITH CONNECTIVE TISSUE DISORDERS AND SURGICAL DISEASES
The aim of the study was to investigate the nature and structure of the final stage of blood coagulation pathology in children with the syndrome of connective tissue disorders (CTD) on the background of surgical pathology. The study involved 109 children with CTD. Known genetic predictors of thrombotic conditions, which indicates a high frequency (87,5-100 %) combined thrombogenic detecting genetic polymorphisms in patients with CTD, including disfibrinogenemias (8,9 % of patients). It was determined that patients with mesenchymal dysplasia in the background surgical disease are at risk for the development of both hemorrhagic and thrombotic complications. This fact must certainly be taken into account during predoperation of coagulation screening and identify a program of intra- and postoperative antithrombotic and hemostatic preventive therapy.