Expression of Genes TLR2, Caspases and them Ingibitors in a Placenta Tissue in Norm and at Premature Birth Infectious Genesis
Process of apoptosis plays the important role in a placenta tissue at premature birth. However molecular mechanisms and ways of regulation of this process are studied insufficiently. In the given work with the help polymerase chain reaction in real time are investigated an expression of genes caspases (CASP 8 and CAS 3) – the basic enzymes of apoptosis and them ingibitors (FLIP and XIAP) in a placenta tissue in norm and at premature birth infectious genesis. Also the comparative analysis with data on expression TLRs in a placenta has been carried out at the same pathology. The obtained data testify to strengthened expression TLR 2 and as consequence of activation a cascade of caspases at development of premature birth. Results of the present work have allowed to assume a hypothesis about the TLR-mediated activation of apoptosis in a placenta at premature birth infectious genesis which confirms representation about a role of hyperactivation of innate immunity in development of pathologies of pregnancy.