INFLUENCE OF NEBVOLOL ON FUNCTIONAL STATE OF ENDOTHELIUM, MICROCIRCULATION, TRANSPORT CHARACTERISTICS OF PERITONEAL MEMBRANE AND RESIDUAL KIDNEY FUNCTION IN PATIENTS ON PERITONEAL DIALYSIS
In the last years peritoneal dialysis, as a method of substitutive kidney therapy, is becoming more popular. One of the main reasons of method inadequacy is decreasing ability to perform adequate ultrafiltration against a background of increasing of peritoneal transport. In case of endothelial dysfunction production of nitric oxide, reactivity and permeability of vessel wall is changing, what is leading to changes in transport abilities of peritoneum and to deterioration of kidney function. Ability of nebivolol to correct endothelial dysfunction and to influence to state of microcirculation system, transport abilities of peritoneal membrane and residual kidney function in patients on peritoneal dialysis was discovered. Positive influence of nebivolol on endothelial function and state of microcirculation and related to this decreasing permeability of peritoneal membrane for low molecular weight substances and improvement of residual kidney function was brought to light.