THE ADAPTIVE IMMUNE RESPONSE FROM THE STUDENTS OF NORTHERN STATE MEDICAL UNIVERSITY
Environmental problems in uncomfortable climatic and geographical conditions of life provide not just a summation of different factors of adverse effects, but sometimes an increase in the order of magnitude and more negative impact of each of them. Extreme climatoecological conditions of the North prevent the development of self-regulation processes that return the system to the optimal mode of functioning, which leads to the activation and tension of cellular and humoral immunity and, ultimately - to reduce the reserve capacity of the body. The purpose of the work is to determine the features of the immune status of students 18-29 years old studying at the Northern state medical University, Arkhangelsk. Materials and methods of research. A survey of 30 healthy female students of 1-2 courses (according to the medical cards of the health center of the NSMU), aged 18-29 years, studying at the Northern state medical University, Arkhangelsk. Blood for analysis in volunteers was taken from the ulnar vein in the amount of 6 ml. at 9-10 o'clock in the morning, on an empty stomach. Immunological studies conducted in the laboratory of physiology of immune cells, IFPA, VICKIE RAS, Arkhangelsk, using microscope Nikon Eclipse 50i. The content of phenotypes of CD4+, CD5+, CD8+, CD20+, CD95+; lymphocytes was studied in peripheral blood;the structure of leukogram was determined. Results. The examined students of the Northern state medical University were found to have reduced reserve capabilities of immune homeostasis due to increased cytotoxic activity (CD8+) in 56,66±2,49%, increased apoptosis activity (CD95+) in 53,33±2,42% of patients, against the background of a deficit of total T-lymphocytes (CD5+) in 90,00±3,14% of the examined. Have 16,66±1,35% of the surveyed students was lymphocytosis; lymphopenia meet 13,33±1,21% cases; monocytes from 10,00±1,04% of the surveyed students; neutropenia was observed in 33,33±1,91% of the students. Conclusions: the revealed immune imbalances and their wide frequency of distribution can be the cause of environmentally-dependent immunodeficiency, reduce the effectiveness of adaptive immune responses and the development of possible chronic pathology.