CLINICAL AND PATHOGENETIC 3 APPLICATION OF THE HSP70 HEAT SHOCK PROTEIN IN MYOCARDIAL INFARCTION ON THE BACKGROUND OF CHRONIC OBSTRUCTIVE LUNG DISEASE
In order to assess the clinical and pathogenetic value of the heat shock protein HSР 70 in patients with myocardial infarction (MI) on the background of chronic obstructive pulmonary disease (COPD), 65 patients were examined: 28 MI patients and 37 MI patients with COPD, as well as 20 somatically healthy individuals. ELISA determined the level of HSP70. The highest level of HSP70 was found in MI patients with COPD, especially in the early stages of hospitalization. The obtained data on the relationship of HSP70 with the depth of myocardial lesion suggest the possibility of using this heat shock protein not only as a marker of early diagnosis of MI in patients with COPD, but also as a marker of the severity of MI in comorbid patients with COPD. This will facilitate early detection of coronary events in patients with COPD, which is especially important given the high frequency of erased forms of MI and atypical symptoms of MI in patients with COPD.