The Correlation Between Redox Parameters of the Blood and Synovial Fluid and the Radiographic Grade of Knee Osteoarthritis
The present study revealed the development of oxidative/nitrosative stress in the blood plasma and mononuclear fraction, and especially in the synovial fluid in patients with knee osteoarthritis. It was ascertained that such parameters as pro-oxidant activities of myeloperoxidase and xanthine oxidoreductase in the mononuclear fraction, the content of uric acid in the plasma, the concentration of malondialdehyde in the plasma and synovial fluid, also the superoxide anion-obviating activity correlated with radiographic grade of knee osteoarthritis and might be used as an informative diagnostic and predictive test.