PATHOGENETIC SUBSTANTIATION OF TREATMENT OF PURULENT POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH ORAL MUCOSA CANCER
The comparative analysis of the qualitative and quantitative composition of plaque and HIF-1a and NF-kBp65 tissue level in patients with oral mucosa cancer Т<sub>2-3</sub>N<sub>0-1</sub>M<sub>0</sub> with a high risk of purulent inflammatory complications, showed that a combined systemic and topical use of the lactoferrin-based drug in addition to the standard treatment in the postoperative period leads to a decrease in the incidence and number of the excess clinically significant concentration of oral microbes, content of HIF-1a and NF-kBp65 transcription factors, intensive expression of HIF-1a in the tissue, to the restriction of HIF-1a translocation to the nucleus. The use of the lactoferrin-based drug proves the importance of pathogenetic components for oral mucosa cancer and shows the substantiation and effectiveness of its inclusion in the scheme of prevention and treatment of purulent inflammatory diseases in this group of cancer patients.