NTIBODIES SPECIFIC TO STEROID HORMONES AND <i>CYP1A1, CYP1A2, GSTT1, GSTM1 </i>GENES POLYMORPHISMS IN HEALTHY MEN AND LUNG CANCER PATIENTS
Serum antibodies to estradiol (IgG-Es) and progesterone (IgG-Pg) and CYP1A1 (rs 4646904), CYP1A2 (rs 762551), GSTT1 (del), GSTM1 (del) genes polymorphisms were studied in 267 healthy men and 203 lung cancer (LC) patients. There were no any differences in CYP and GST variants frequently between groups. The frequency of IgG-Es high levels in LC patients with C allele of CYP1A2 and GSTT1«+», GSTM1 «+» was higher (p = 0.002) than in patients gomozygotes AA, and LC OR = 5.5. High individual rations IgG-Es/IgG-Pg in healthy donors with GSTT1 «+» and GSTM1 «+» were found more rarely (p = 0.002) than in the same with GSTT1 «0/0», GSTM1 «0/0» and LC OR=10.5. In LC patients TT CYP1A1 gomozygotes high IgG-Es/IgG-Pg rations were more frequently then in the same with C allele of CYP1A1, and LC OR=6.9. So the supposition about interactions of specific immune reactions on the steroid hormones and biotransformation enzymes were confirmed.