A study of the effect of polyvitamins and fish oil preparations on the morpho-functional properties of vascular endothelium and nitric oxide production in children with pyelonephritis
With the aim to justify the expediency of using polyvitamins and fish oil for restoration of endothelium-dependent vascular dilatation in patients with pyelonephritis and endothelial dysfunction 82 children aged from 8 to 17 years were examined: 42 children with pyelonephritis, who had endothelial dysfunction (basic group) and 40 practically healthy children (control group). As has been found, traditional treatment in combination with two-week intake of polyvitamins and fish oil leads to restoration of NO-synthetase activity of the endothelium against the background of a decrease of nitric oxide hyperproduction (its stable metabolites level), desquamation of the endothelium and enhanced thrombocyte aggregation ability, and also to reduction of the erythrocyte sedimentation rate and of leukocyturia levels in patients of these groups.