A History of the Drug Dibazole
Based on fi rst-hand reports, especially those of O.F. Guinzbourg, M.A. Rozin, and L.S. Efros, the background and history of the developt in the USSR of the drug Dibazole is reconstructed. The role of the largest Russian pharmacologist schools, founded by N.V. Lazarev and S.V. Anichkov, is illuminated in the pharmacological research on Dibazole and its clinical adaptation. The current pharmaco-therapeutic profi le of Dibazole is characterized, and special attention is given to its adaptogenic and immuno-modulating properties. The problems and ambiguous results of using adaptogenes, including Dibazole, for cancer prophylaxis are considered. The drugs - structure analogues of Dibazole are characterized briefl y. The most important methods of the laboratory synthesis and manufacturing of Dibazole are examined.