CHLAMYDOPHILA PNEUMONIAE AND MYCOPLASMA PNEUMONIAE: THEIR DIAGNOSING AND INFLUENCE ON WHEEZING DEVELOPMENT AND BRONCHIAL ASTHMA EXACERBATION
311 children aged from 2 to 17 with protracted Bronchial Asthma exacerbation and lingering Cough Syndrome (more than 3, but less than 8 weeks) were tested with Enzyme Immunoassay (EIA) and Molecular Genetic (PCR) methods to detect the presence of Chl. pneumoniae and M. pneumoniae. 150 children (48 %) had Chlamydial infection or Mycoplasmal disease, both methods were positive in 42 of 53 % cases. In the same group there was detected that not only asthmatic children had an increase of total IgE in blood plasma, but also those who had infectious bronchitis. β2 agonists and inhalant glucocorticosteroids were used during Bronchial Asthma exacerbation associated with Chl. pneumoniae and M. Pneumonia. In 4 weeks and 6 month after initiation of medical and rehabilitation treatment, results of inhalation test with hypertonic saline NaCl increasing concentration, confirmed nonspecific bronchial hyperreactivity associated with Chl. pneumoniae and M. pneumoniae.