IMMUNOPATHOPHYSIOLOGICAL FEATURES OF ADAPTIVE IMMUNITY IN AUTOIMMUNE DISORDERS OF THE ENDOCRINE GLANDS (AUTOIMMUNE THYROIDITIS, TYPE 1 DIABETES)
The study involved 25 patients with combined pathology: autoimmune thyroiditis with underlying type 1 diabetes, and 30 healthy people in the control group. We found out the dependence of the level of thyroid and pancreatic autoantibodies on the functional state of thyroid gland and duration of autoimmune thyroiditis. The study included patients aged 20-43 having autoimmune endocrine disorders: autoimmune thyroiditis (n=150), autoimmune thyroiditis and type 1 diabetes (n=25), and almost healthy people (donors) in the control group (n=30). We described the pathophysiological role and diagnostic significance of adaptive immunity indicators in the phenomenon of auto-aggression directed to the pancreatic β-cells and thyrocytes.