Features of fatty acid composition of blood serum in vibration disease
Vibration disease (VD) is one of the most common occupational diseases. It is characterized by complex symptoms of the clinical picture. The study of the features of the course of VD of different severity from the position of metabolic disorders is an urgent issue, since it will allow to establish the most significant prognostic indicators in the future. Production vibration early enough leads to a shift in serum levels of higher fatty acids (HFA). This is largely due to the fact that HFA are structural units of lipids of cell membranes and precursors of biologically active mediators, are actively involved in the processes of energy supply. At present, there is no information on whether there is a reliable relationship between this indicator and the severity of clinical manifestations of VD. The aim of the study was to study the dependence of changes in the concentration levels of fatty acids, reflecting the specifics of metabolic disorders in VD, on the severity of pathological manifestations. The study of blood serum of workers of vibration-dangerous professions with vibration disease established in the clinic was carried out. The fatty acid composition of blood serum was studied using a gas chromatographic complex equipped with a flame ionization detector and a capillary column with a polyethylene glycol phase modified with nitroterephthalic acid. It is established that the complication of the clinical picture of vibration pathology on the background of authentic level shifts HFA: eicosatrienoic and arachidonic in males, y-linolenic and eicosatrienoic in women. In addition, men tend to increase the levels of nervonic, eicosapentaenoic and docosahexaenoic acids with worsening of the degree of VD. Compared with workers exposed to vibration, but without pathological disorders, men have high levels of nervonic and docosahexaenoic, women-nervonic and palmitoleic acids. With varying degrees of severity of clinical manifestations of vibration pathology, certain changes in the metabolism of the HFA are observed. The nature of shifts in their concentration levels reflects the depth of violations of energy exchange reactions, synthesis of Pro-and anti-inflammatory mediators, membrane-pathological processes. The study of fatty-acid composition of blood serum in VD has prognostic value of detected level shifts and HFA can be estimated, what the metabolic process in the body of the examinee was subjected to the most grave violations, and to adjust the complex of therapeutic measures.