REPERFUSION-REOXYGENATION SYNDROME AS A PROBLEM OF RECONSTRUCTIVE SURGERY IN CRITICAL ISCHEMIA OF THE LOWER EXTREMITY
The presented review highlights the topic of the damaging effect of tissue reoxygenation during revascularization of the lower extremity. This work examines the possible pathogenetic mechanisms of the occurrence of reperfusion-reoxygenation syndrome: from the molecular basis of endothelial damage to clinical manifestations. The development of reperfusion syndrome is an obligatory consequence of the restoration of blood flow in the ischemic limb after carrying out reconstructive and restorative operations on the vessels. Therefore, today in angiosurgery, there is an acute question about the possibilities of correction and prevention of this condition, tk. Even with a successfully performed surgical intervention, due to irreversible cell death of tissues due to reperfusion injuries, surgeons are far from always able to save a limb. The goal is to search for optimal drugs for angioprotective and antioxidant therapy as methods of influencing the main links in the pathogenesis of this syndrome. These and other issues are discussed in detail in the materials presented.