Homeostatic disorders in chronic obstructive pulmonary disease
The research studied the parameters of the vascular endothelium functional state (the ratio of endothelial function, levels of endothelin-1 and natriuretic peptide of type C) of peroxide oxidation of proteins (carbonyl derivatives), of lipids (TBA-active products), of antioxidant protection (superoxide dismutase) and inflammation (C - reactive protein and fractalkine) in 35 patients with chronic obstructive pulmonary disease (COPD) and 50 somatically healthy persons of Astrakhan region. It was revealed that COPD patients had endothelial dysfunction and oxidative stress due to the peroxide destruction of both lipid and protein molecules. We stated a direct correlation between the level of plasma endothelin-1 and the level of TBA-active products reflecting an increase in production of vasoconstrictors with increasing levels of lipid peroxidation products in patients with COPD. It has been proven that the study of 4a/4b polymorphism of the eNOS gene is important in the diagnosis of endothelial damage in COPD.