Clinical manifestations and platelet hemostasis parameters in patients with atherothrombotic stroke
Clinical manifestation and platelet homeostasis parameter results in patients with atherothrombotic strokes are presented. The design of investigation was “case-control”: 102 patients with atherothrombotic stroke in an acute stage and 37 healthy persons were examined. Neurological examination with the assessment of the patient condition severity in points according to stroke scales, brain computer tomography, clinical blood analysis, adenosindiphosphate-induced agregometry and fl ow-cytometry on the 10-thday of the stroke, molecular genetic investigation of the gene of Willebrand factor platelet receptor were performed in all the patients. There was the mean platelet volume increasing in patients with atherothrombotic stroke upto the 10–14-th day of illness (9,9±1,0 fl, 11,0±11,6 fl ; p < 0,05). Th e different data were obtained from agregometry and flow cytometry concerning platelet activity in stroke patients and control group. The direct significant correlation of 1bα receptor and point at National Institute of Health Stroke Scale on discharge was revealed in patients with stroke. Molecular genetic investigation revealed significantly higher frequency of 1bα gene mutant allele in patients with atherothrombotic stroke compared with control group.