The basic mechanism of the pathogenesis of premature placental abruption of a normally positioned placenta
A premature abruption of a normally positioned placenta (PANPP) is a severe complication of pregnancy, when the placenta is completely exhausted and loses its functional potential. The leading role in the pathogenesis of PANPP belongs to hypertonic dysfunction of the myometrium, the development of which is mainly caused by morphological and functionsl insufficiency of myometrial segments of uteroplacental arteries and «venous congestion of the uterus». Formation of thrombi in the vessels of the uteroplacental circulation and intervillous space should be regarded as signs of the readiness to launching a cascade of pathological reactions of the PANPP process. First of all, this requires control over the myometrial tone, the change of which can be judged by an enhanced resistance to uterine artery blood flow.