Blood pro- and antioxidant system in patients with amyotrophic lateral sclerosis
It has been investigated the state of blood pro- and antioxidant system at patients with different form and duration of the amyotrophic lateral sclerosis (ALS). Diagnosis of ALS were determined by revised El Escorial criteria and Awaji criteria. We assessed the catalase, superoxidedismutase (SOD) activity and products reacting with thiobarbituric acid (TBA-P) con­centration of 82 patients and 25 healthy volunteers. It has been shown that patients with the most malignant form of bulbar ALS and shorter than 1 year, recorded a significant increase in the concentration of TBA-P and the decrease in the activity of SOD; in patients with cervical-thoracic form of ALS, and the disease duration from 1 to 4 years revealed the activation of secondary lipid peroxidation processes and a significant reduction in the activity not only of SOD and catalase. A direct corre­lation between the activity of SOD and functional neurological deficit scale (ALSFRS-R), but only in case of disease duration less than 1 year. It was shown the high diagnostic specificity of the studied the parameters blood pro- antioxidant system in patients with ALS but lower diagnostic sensitivity.