ADVERSE REACTIONS IN COMPLEX TREATMENT OF GASTRIC CANCER
39 patients with gastric cancer T3-4N1-2M0 received up to 40 isogray adjuvant remote gamma-therapy in accelerated fractionated scheme and split-course. 20 patients from the study group received chemotherapy, including endolymphatic administration of 5 mg of methotrexate and intraperitoneal administration of 50 mg/m2 of eloxatin diluted in 250 ml ozonized 5% glucose solution every four days, twice during the course of radiation therapy. 19 patients in the control group received intravenous chemotherapy before radiotherapy and in the middle of radiotherapy interruption. Patients from the study group received summarily 10 mg of methotrexate and 300 mg/m2 of eloxatin, patients from control group received in total 170 mg/m2 of eloxatin, 800 mg/m2 of 5-fluorouracil and 40 mg/m2 of leucovorin. Gastrointestinal and hematologic complications were found in 22% and 17% respectively in the study group, and 84% and 34,5% respectively in control group. Combined use of endolymphatically administered methotrexate and intraperitoneally administered platinum drugs with ozonized glucose solution has a significant radioprotective effect that allows patients to receive a full dose of radiation therapy without interruption.