Experimental model of damages in structural and functional state of extracellular matrix of periodont
The negative influence of mixture of varfarin and cuprenil on extracellular matrix was found. In gingiva the content of oxyproline was decreased to 70.7%; glycosaminoglycans - 26.0%. In the periodontal tissue loss of glycosaminoglycans was 10.4%. Materials and methods. In current study two experimental groups were used. Both of groups (pure and modeling) consist of 8 rats. Rats from modeling group got per os varfarin 3 days per week (10 mg/kg,) and 7 days per week cuprenil (20 mg/kg). Duration of experiment was 55 days. Results of the study. Model of periodontitis in experiments on 16 white 1.5-month-old rats was rendered. Inflammatory and insufficient activity of antioxidant system in periodontal tissues also was observed. Cytomorphological damages of extracellular matrix in mucous membranes of oral cavity took place simultaneously with decrease of number of active fibroblasts. At the same time the trophic potentialities of extracellular matrix were invariable.