EFFICIENCY STUDYING OF p-ESTRADIOL, INDOMETOFEN AND GENISTEIN AS RADIOPROTECTORS AT THE ACUTE IRRADIATION
The purpose of the study was an experimental estimation of the radioprotective efficiency of p-estradiol, non-steroidal estrogen indometafen and the phytoestrogen genistein. The estimateon of radioprotective activity of drugs was performed by studying of 30-daily survival of irradiated mice and rats, and the average life expectancy of the dead animals. To identify possible mechanisms of radioprotective effect of genistein on bone marrow investigated the number of peripheral blood leukocytes of rats at different times after irradiation. Found that when administered intramuscularly at a dose of 40 mg / kg for 5 days before irradiation, p-estradiol increases the survival rate of mice exposed to radiation at 8-58%. When administered orally for 5 days indometafen to the radiation exposure dose of 30 mg / kg, the survival of irradiated mice increased on average by 20-40%. Synthetic genistein showed radioprotective properties when using the drug At a dose of 200 mg / kg for 24 h before irradiation.