DEVELOPMENT FACTORS OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH GOUT AND ARTERIAL HYPERTENSION
The endothelium functional status is characterized in patients with gout and arterial hypertension (AH) - the main group, in comparison with two comparison groups (patient with gout and arterial hypertension properly). The authors of the article have evaluated the status of purine (uric acid of blood and urine), lipid (total blood cholesterol and its fractions, triglycerides), carbohydrate (fasting blood glucose) metabolism, as well as oxidation-reduction system (malondialdehyde and superoxide dismutase), kidney functional status (blood creatinine and glomerular filtration rate). All the patients were tested for endothelium-dependent vasodilatation for Celermajer D. with determination of the main parameters of endothelial dysfunction (ED) and were carried out a correlation analysis between them and other anamnestic and biochemical values. A regressive model was constructed from the main factors that cause the development of ED in such patients.