ANTIRETROVIRAL THERAPY INFLUENCE ON CYTOKINE PRODUCTION IN TUBERCULOSIS ASSOCIATED HIV-PATIENTS.
This paper presents the peculiarities of cytokine profile in tuberculosis associated HIV patients at various stages of the disease at the background of antiretroviral therapy (ART). The research included 90 tuberculosis associated HIV patients in the age of 19 to 53 (in average 27,3±3,3; 85% male) In the result of the investigation we revealed considerable differences between cytokine profiles of the target patient groups and control figures recorded prior to the therapy. The dynamics of cytokine and receptor changes was diversified in the course of treatment: TNF-б, IL-6 and SRI TNF-б concentration increased sharply, while SR IL-6 contents decreased. The diversified dynamics of soluble cytokine receptors under antiretroviral therapy conditions in the target patient groups allow developing additional criteria for both indications for the therapy and its effectiveness.