ANTITOXIC ACTIVITY OF PYRIMIDINES (STRUCTURE - ACTIVITY)
For the first time, an attempt was made to summarize information on the experimental (preclinical) study of the antitoxic activity of pyrimidine derivatives (PP) - their influence on the dynamics and outcomes of the toxic process in various forms of its manifestation - acute, subacute, xenobiotic poisoning, as well as chemically induced types of pathology. The relationship between the chemical structure and the antitoxic activity of PP was revealed. The analysis made it possible to hypothesize the diversity of potential functions characteristic of these compounds, which may be related to their ability to regulate the interconversions of free radical compounds causing the “oxidative potential” of the cells, resulting in a stabilizing effect on the cell membranes.