Differences in the hemostasis in survived and died patients with acute necrotizing pancreatitis
Objective. To analyze the differences in the hemostais at patients with acute pancreatitis Materials and methods. In 25 patients (mean age: 46,2 ± 6,74 years); partial thromboplastin time (APTT), prothrombin time (results expressed as INR), thrombin time, fibrinogen concentration, the concentration of D-dimer, protein C, protein S, plasmin inhibitor, plasminogen and von Willebrand factor (vWF), the activity of antithrombin III, hemoglobin concentration (Hb), hematocrit (Ht), number of erythrocytes (RBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin content (MCH), mean corpuscular hemoglobin concentration (MCHC), the width of the distribution by volume of erythrocytes (RDW), platelet count (PLT) value trombocrit (PCT), mean platelet volume (MPV), platelet distribution width by volume (PDW) were evaluated. Statistical processing. The data were treated with the use of the exact one-sided Mann-Whitney test, sign test and Wilcoxon rank sign test. Results. In patients with acute pancreatitis there were identified significant changes in platelet, coagulation, fibrinolytic and anticoagulant mechanisms. Conclusion. The reduction in the activity of antithrombin, protein C and plasminogen was noted in the group of died patients.