RS1800471 POLYMORPHISM OF THE TGFΒ1 GENE IN SEBORRHEOIC KERATOSIS
The aim of the work was to study the role of the rs1800471 polymorphism of the TGFβ1 gene in the development of seborrheic keratosis (SK). Materials and methods. Under observation were 97 patients with KS aged 25 to 86 years. The rs1800471 genotyping of the TGFβ1 gene was performed by polymerase chain reaction followed by electrophoretic detection using reagents "SNP-express, TGFβ1 (Arg25Pro)". Results. An association of the ancestral Arg/Arg genotype and the Arg-allele polymorphism rs1800471 of the TGFβ1 gene with the development of SC was established (χ2=7.34; p=0.27; and χ2=5.04; p=0.26). It has been shown that the genetic risk of developing MC is associated with the Arg/Arg genotype and the Arg allelic polymorphism rs1800471 of the TGFβ1 gene. An increase in the Arg/Arg genotype by 1.4 times increases the risk of developing KS by 3.5 times. It was found that the homozygous ancestral genotype Arg/Arg increases the likelihood of developing epidermal hyperplasia, neovasculogenesis against the background of hyperproduction of the growth factor TGFβ1. Conclusion. The study of the polymorphism of the TGFβ1 gene and the identification of the features of the expression of the encoded cytokine will make it possible to predict the risk of developing SK and personalize the treatment and rehabilitation program for managing patients.