THE FREQUENCY OF OCCURRENCE HPV HCR AT PATHOLOGY OF CERVIX UTERI IN CHELYABINSK REGION
The frequency of occurrence, spectrum of genotypes and virus load of DNA HPV HCR have been studied in 97 patients with СIN I, II, III degrees and a carcinoma in situ, being on a dispensary observation in Chelyabinsk regional oncologic clinic. The frequency of HPV HCR revealing has amounted 59,8 % from all surveyed persons and was enlarged in direct ratio degrees of neoplastic changes of a cervix uteri. The distribution of HPV HCR genotypes among the HPV-positive surveyed persons has shown that in different percent of cases 12 genotypes (16,1 8,31,33,35,39,45,51,52,56,58,59), with prevalence ВПЧ 16 types in 33 % and ВПЧ 31 types in 12 % have been taped all. At the research of a virus load in patients with СIN I in 50 % of cases the significant virus load prevailed, in group with CIN II-III practically in equal value were defined the significant and raised virus load (46,8 and 43,7 % accordingly), in group with Cr.in situ in 64,2 % there was a raised load, at a total absence of a little significant load. The average index of a virus load also increased from group to group: СIN I - 4,59 lg, СIN II-III - 4,74 lg, Cr.in situ - 5,33 lg (HPV on 10<sup>5</sup> cells).