SPINE SKELETAL TISSUES MORPHOGENESIS REGULARITIES IN CHILDREN WITH CONNECTIVE TISSUE DYSPLASIA
Morphological study of bone tissue, skeletal muscles and tendons has been carried out on children with the dysplastic syndrome of instability in the cervical department of the spine. The unevenness of the concentration of perivascular cellular elements of bone tissue - their dominance in the inner layer of the periosteum, and their almost complete absence in the endosteum, which can reflect the formation of special (altered) metabolic conditions in the endosteum that interfere with migration, proliferation and / or differentiation of cambial osteogenic cells with subsequent development of osteoporosis has been detected. In some areas of fibroblastic replacement of broad osteon canals, the induction of fibrillogenesis in compact bone can serve as a compensatory mechanism that facilitates the fixation of the ligamentous apparatus to bone tissue in case of the blood flow disturbance and prevents further degradation and bone injury. It is characteristic that in case of the exudative- infiltrative component of the inflammatory reaction in tendons and skeletal muscles, the compensatory reactions of the bone tissue were manifested by osteocytic resorption and its replacement by fibrous elements. In case of lymphocytic infiltration of tendons and perimysium, osteoclastic resorption with compensatory osteogenesis in the endosteum took place.