On the Possibility of Hyaluronic Acid Drugs Use for the Hip Joint osteoarthritis
Hyaluronic acid is a high molecular weight substance from the group ofglycosaminoglycans, the function of which is to retain moisture and maintain the elasticity of cartilage, as well as stimulate the synthesis of extracellular matrix by fibroblasts. The change in the structure and amount of hyaluronic acid is accompanied by a decrease in the protective function of the joint tissues, contributes to the progression of osteoarthritis. The introduction of exogenous hyaluronic acid into the joint cavity (viscosupplementation) is clinically and theoretically justified, it improves the rheological properties of synovial fluid, stimulates the synthesis of endogenous hyaluronic acid, maintain joint mobility, and reduce the intensity of pain. The article presents the results of clinical studies confirming this position by the example of intra-articular injection of hyaluronic acid into the hip joints. An assumption was made about the possibility of preventing the onset and progression of osteonecrosis of the hip joint against the background of the introduction of hyaluronic acid.