Molecular genetic prediction of pregnancy complications in young healthy women
The frequency characteristics of gene polymorphisms (FVL-169G>A, FII-20210G>A, AGTR1-1166A>C, VO3-894G>C, MTHFR-677C>T, MTHFR-1298A>C, MTRR-66A>G) associated with the risk of obstetric and perinatal complications were studied. This examination was conducted in 130 planned-pregnancy healthy young women. Mutant homozygous with FVL-1691AA и F//-20210AA genotypes were not identified in those women. The number of MTHFR-677TT (5 %) and MTHFR-1298CC (12 %) genotypes carries did not differ from those in the general population. The frequencies of the occurrence of the heterozygous FVL-1691GA (0,8 %) genotype; mutant genotypes F//-20210GA (1,5 %), AGTR1-1166CC (7,7 %), VO3-894CC (10,0 %), associated with the risk of pregnancy complications were very low in those women. The frequency of mutant genotype MTRR-66GG was higher in the women surveyed than in the general population (31 % vs 15-25 %). We concluded that selective thrombophilia, arterial hypertension and hyperhomocysteinemia gene screening based on prior personal and/or family history of arterial hypertension, pregnancy complications or venous thromboembolism was more cost-effective than a universal preconception screening in all planning pregnancy women.