Simultaneous Liver-Pancreas Transplantation: the First Russian Experience
Combined liver-pancreas transplantation is considered to be a reasonable treatment of end-stage liver disease and concomitant insulin-dependent diabetes mellitus patients, so it may become a standard treatment of this category of patients. As known, diabetes mellitus negatively affects the long-term results of isolated liver transplantation and increases a risk of posttransplant complications. In May 2010 there was performed a first in Russia simultaneous liver-pancreas transplantation to 17-years old recipient, suffering with liver cirrhosis (as a result of autoimmune hepatitis) and concomitant insulin-dependent diabetes mellitus. In the article an overview of indications for simultaneous liver-pancreas transplantation, different operative techniques, immunological aspects and immunosuppression regimes are given.