ASSOCIATIONS OF INTERLEUKIN-6 AND INTERLEUKIN-10 WITH SOME INDICATORS OF THE SEVERITY OF CHRONIC HEART FAILURE AGAINST THE BACKGROUND OF RHEUMATOID ARTHRITIS
The aim. Comparative analysis of the levels of interleukin-6 (IL-6) and interleukin-10 (IL-10) in patients with chronic heart failure (CHF) and rheumatoid arthritis, as well as the search for possible associations with the morphofunctional parameters of the myocardium. Materials and methods. The study group consisted of 134 patients with CHF with RA, and the comparison group consisted of 122 patients with CHF without RA. Functional class of CHF, who participated in the study of patients according to NYHA I-II. The volume of CHF therapy in the study group and the comparison group were compared. The basic anti - inflammatory drug for the treatment of RA is methotrexate. The morphofunctional parameters of the myocardium were evaluated, as well as the levels of IL-6 and IL-10 and their possible relationship with the morphofunctional parameters of the myocardium. The processing was carried out using the program STATISTICA 10.0; the paper presents statistically reliable results. The critical level of significance when testing statistical hypotheses is p <0.05. Results. Statistically significant differences in the values of IL-6 were revealed: in the group of CHF and RA, the level was 18.3±5.05 pg / ml; in the group of CHF without RA, 5.3±1.9 pg / ml (p=0.004). Comparative analysis of IL-10 levels revealed no significant differences: 5.9±1.9 pg / ml and 5.2±0.7 pg / ml, respectively (p=0.4). In the group of CHF and RA, statistically significant correlations of IL-10 with LVEF (r=-0.1; p=0.02) and NT-proBNP (r=-0.1; p=0.04), as well as IL-6 with NT-proBNP (r=0.06; p=0.03) were obtained. Conclusion. Taking into account the obtained associations, it can be assumed that the increase in the concentration of IL-6 may lead to the destabilization of the course of CHF against the background of RA, but to confirm this theory, prospective studies are necessary