Anti-HIV microbicides activity based on adducts of carbon nanoclusters
Taking into account the increase in the number of new HIV infections among women, especially in developing countries, the development of topical microbicides is an important part of comprehensive measures to prevent HIV/AIDS. In this work we investigated the water-soluble adducts of carbon nanoclusters (ANCC), which are active against strains of HIV-1, for the development of anti-HIV microbicides. All tested water-soluble adducts of carbon nanoclusters, which differ in method of preparation (reference, № 2, № 5, № 6, ANCC, and ANCC solution), are low-toxic to cells CEM SS: 50% toxic dose was not achieved. Study of antiviral activity showed that water-soluble adducts of carbon nanoclusters have a low inhibitory activity against HIV-infection in vitro. 50% effective dose (ED50) of this group of drugs is in the range 21.4 - 27.5 [ig/ml. It was revealed significant virucidal effect: all the samples can inactivate the virus, preventing infection of target cells. The most effective drug is a light fraction of ANCC.