Detection of senile asthenia syndrome and renal dysfunction in patients with coronary heart disease
Relevance . Patients with coronary heart disease (CHD) older than 60 years are characterized by the development of senile asthenia syndrome (SA), which leads to an increased risk of complications and increased mortality. Reduced renal function also plays a significant role in reducing muscle strength, balance disorders, and increasing the risk of falls. Objective: to study the frequency of SA syndrome and renal dysfunction in inpatient patients with IHD, to assess the impact of age, gender, comorbidities, glomerular filtration rate (GFR) on the severity of these indicators. Methods. To identify SA syndrome, patients were surveyed using three questionnaires: Fried, "Age is not a hindrance"(Pirogov Russian national research UNIVERSITY, RUDN) and the SA criteria in the Study of Osteoporotic Fractures - SOF-index. GFR was determined using the CKD-EPI formula. Patients were divided into 3 age groups: 1st-middle age, 2nd - elderly, 3rd-senile. Results. 40 patients (men - 19, women - 21) with IHD were examined: stable stenocardia - 17 people, unstable-13 people, with primary myocardial infarction (MI)- 8 people, repeated MI-2 people. aged 50 to 86 years (average 69.8±9.3 years).Group 1 included 6 people, group 2-24 people, and group 3-10 people. SA syndrome was detected in 50% of the examined patients, preaste-NII (PA)-in 37.5%, not detected in 13.5%. in group 1, SA syndrome was diagnosed in 66.6%, in group 2 in 91.1%, and in group 3 in 100% of patients. The prevalence of SA in women was revealed. Impaired renal function - in 20% of patients without SA, in 26.6% with PA and in 65% with SA. Hypertension (GB) in group 1 was observed in 66%, in group 2-in 79.0%, in group 3-in 100% of patients. Type 2 diabetes mellitus (DM) was more common in group 2 (20.0%) and group 3 (35.0%) compared to group 1 (16.6%). Calculating GFR allowed us to determine the stages of chronic kidney disease (CKD). In patients without SA, CKD C3-C4 was detected in 20.0%, with PA-in 26.7%, with SA - in 65.0%. Conclusion. In various forms of IHD, the presence of PA and SA worsens with age, the PRO-phenomena of IHD are more severe in them, functional disorders of the kidneys also increase due to age and an increase in the degree of SA. Correction of SA and renal function may improve the prognosis of patients with IHD.