Efficiency of neuroprotective treatment of coronary stroke with application of Corvitin
Introduction. Corvitin - is a complex of quercetin with polyvinylpyrrolidone (lyophilized powder for solution for injection). The spectrum of the pharmacological effects of the intravenous form of quercetin is quite wide. Corvitin has a neuroprotective effect on neurons in the ischemic brain tissue. It has been established that the basic mechanisms of neuroprotective korvitina are membrane-stabilizing, antioxidant, anticoagulant, antiplatelet and anti-apoptotic effects (1,2). Considering the above, we have set a goal to study the clinical efficacy of corvitin in ischemic stroke in the group of patients who were hospitalized during the therapeutic window. Material and methods. Under our supervision there were 70 patients with acute ischemic stroke who were taken to the emergency period of not more than 6 hours after stroke onset. Inclusion criteria were: age between 35 and 75 years of age, the severity of Rankin scale from 2 to 4 points during the second stroke of the first prescription for more than 6 months. We excluded patients with severe somatic pathology (myocardial infarction, pneumonia, cancer, decompensated diabetes, etc.), A malignant, uncontrolled conventional therapy antihypertensives hypertension receiving any other neuroprotective. All patients received standard treatment from the time of admission. This anticoagulant, antiplatelet drugs, vasotonic therapy, infusion therapy to hemodilution. In addition, 44 patients (main group) received supplemental corvitin by the following procedure: 1 vial preparation containing 0.5 g of corvitin dissolved in 100 ml of isotonic sodium chloride solution and administered intravenously for 30 minutes 1 time per day in the morning. The duration of treatment with corvitin - 10 days.