Extrapolation of the data of morphological liver damage in experimental opistorhoze golden hamsters per person
Aim. the extrapolation of morphological liver damage in experimental data opistorhoze Syrian hamsters per person for the assessment of the Syrian hamster as an experimental animal in the study opisthorchosis. Material and methods. Studies were conducted on laboratory animals Syrian hamsters Mesocricetus auratus and autopsy material with human liver opisthorchosis. Changes in liver opisthorchiasis studied at superinvazionnom opistorhoze in humans and experimental superinvazionnom opistorhoze in Syrian hamsters. For objectification studies tested used morphometric techniques and statistical methods of data processing. Results. Morphological picture of the liver when superinvazionnom opistorhoze in humans and experimental superinvazionnom opistorhoze in Syrian hamsters have common features and is characterized primarily by the presence of inflammatory cell infiltrates, fibroplastic reactions around the ducts, the presence of parasitic granulomas and cysts forming holangioektaz change the proliferative activity of hepatocytes and ductal epithelium. Conclusion. Morphology of the liver in superinvazionnom opistorhoze in humans and experimental superinvazionnom opistorhoze in Syrian hamsters have common features that can adequately extrapolate morphological changes in the liver resulting in experimental opistorhoze per person. The study results allow us to consider the Syrian hamster as an adequate model for studying opisthorchosis.