CHANGES IN BCL-2 PROTEIN FAMILY EXPRESSION IN THE LIVER AND SERUM CYTOKINES LEVEL AT PERSISTING BACTERIAL INFECTION
Expression of apoptotic regulatory proteins (Bcl-2, Bad) in the liver and cytokines (IL-1ß, IL-1ß RA, IL-2, IL-4, IL-6, IL-10, IL-17, IL-18, TNF-a, INFg) serum level were estimated in 18 wistar mail rats at reproducing focal peristing infection created by Staphylococcus aureus (strain 209). Findings suggest dynamic interaction of Bcl-2 family proteins that could be the reason of apoptotic changes in liver cell elements. Proapoptotic bad protein expression correlates with proinflammatory cytokines levels increase. Bcl-2 expression depends on anti-inflammatory and pro-inflammatory cytokines concentrations. Allowing to these facts we suppose the induction of apoptosis to be possibly dependent on cytokine «environment».