EFFECT OF SOLUBLE TUMOR NECROSIS FACTOR-α RECEPTORS ON THE COURSE OF COMORBID PATHOLOGY: CHRONIC HEART FAILURE ASSOCIATED WITH TYPE 2 DIABETES AND OSTEOPOROSIS
The pathogenetic mechanisms by which increased production of tumor necrosis factor-α soluble resceptors type 1 and 2 (TNF-α-SR1 and SR2) affect the development of comorbid pathology associated with chronic heart failure (CHF), type 2 diabetes mellitus (DM), and osteoporosis are not clear. The study included 178 women with CHF and type 2 diabetes (group 1), with osteoporosis and CHF (group 2), with osteoporosis, CHF and type 2 diabetes (group 3). Concentrations of TNF-α-SR1 and TNF-α-SR2 in groups 1-3 were higher than in the group of control ( p < 0.01). It was also found that the levels of both receptors were significantly higher in group 3 compared to patients in groups 1 and 2. Postmenopausal women with elevated levels of soluble TNF-α SR1 and SR2 receptors are diagnosed with an increased risk of developing unfavorable cardiovascular pathology associated with bone mineral density disorders.