INFLUENCE OF THE BENZOFUROCAIN ON THE ACTIVITY OF KAL-LIKREIN-KININE, IMMUNE AND ENDOTHELIAL SYSTEMS IN GEN-ERALIZED PERIODONTITIS IN THE EXPERIMENT
In the work it has been shown that in the improvement of the stomatologic status and decreasing of the periodontal indexes under treatment of generalized periodontitis with non-narcotic analgesic benzofurakain leads the normalization of the activity prekallikrein- kallikrein system and decreasing of bradykinin synthesis. It has been established that anti-inflammatory action of benzofurakain occurs as a results of the decreasing of the content of proinflammatory cytokines and mediator of pain and inflammation, prostaglandin E<sub>2</sub> (PGE<sub>2</sub>). The closed interrelationship between level of PGE<sub>2</sub> and bradykinin (r = 0,8, p<0,001) was found. Pronounced increased in the level of vascular endothelial growth factor and decreasing of vas-oconstrictor endothelin-1 could reflect the stimulation of growth of lymphatic ves-sels and capillarity in the periodontal tissue. The Including of benzofurakaine with anti-inflammatory, analgesic action and cyclooxygenase 2 and bradykinine inhibi-tory activities, in the treatment of GP give the possibility to decreased the obtain doses of nonsteroid anti-inflammatory drugs and will contribute to restoration of neurohormonal balance: interleukine-1, tromboxane A<sub>2</sub>, tumor necrosis factor a, endothelin-1 and prostaglandins.