The role of undifferentiated connective tissue dysplasia in the development of arterial hypertension in patients with 2 type diabetes mellitus
Background. Among patients who seek primary medical care and those hospitalized in a multi-profile hospital, there is an increase in the proportion of persons with comorbid pathology. One of the most common combination is the presence of arterial hypertension (AH) in patients with type 2 diabetes mellitus (DM). The aim of the study was to investigate the frequency and characteristics of AH in patients with DM type 2 combined with undifferentiated connective tissue dysplasia (UCTD). Material and methods. The study was performed at the premises of endocrinology department of Kharkiv Regional Clinical Hospital. The study included 90 patients aged 35 to 45 years who underwent treatment in 2016-2018 with a diagnosis of DM type 2, duration of which was no more than 10 years. Results. Among patients included in the study, phenotypic (visceral and/or skeletal) signs of UCTD were in detected 48 persons (group I), and 42 patients had no signs of UCTD (group II). The average age of patients in group I was significantly lower than in the second group: 36.8 ± 3.2 years and 38.8 ± 2.8 years, respectively (p = 0.003). In both groups, women prevailed, with an unreliable relative increase in their specificity in group I. The average weight and number of obese patients in group I were significantly lower. Patients with signs of UCTD had a more severe course of DM with a tendency to increase in HbA1c levels, more frequent development of diabetic nephropathy with microalbuminuria, reduced glomerular filtration rate, and with a tendency to increase in the incidence of diabetic neuropathy and retinopathy. AH in the presence of UCTD in patients with DM type 2 was found to be significantly more frequent, and in its structure, the proportion of patients with AH stage 2 and 3 increased. Conclusions. In the presence of visceral and/or phenotypic signs of UCTD, AH was significantly more likely to be detected, more severe and not dependent on the DM duration, indicating a possible pathogenetic role of UCTD in the development of AH in patients with DM type 2.