Efficacy and safety of botulinum toxin in patients with primary hyperhidrosis
Aim. To evaluate the duration of abobotulinumtoxin action and changes in effective dose during prolonged treatment in patients with primary bilateral axillary hyperhidrosis.Material and methods. Patients with axillary hyperhidro- sis who were treated with abobotulinumtoxin for at least 3 years were enrolled in our study. The severy of hyperhidrosis was assessed by Hyperhidrosis Disease Severity Scale. To evaluate the effect of treatment we used dose coefficient that reflected the duration of action by 1 cm2.Results. Ninety eight patients (72 females and 26 males, age of 18 to 60 years) with primary axillary hyperhidrosis (average duration of 8.1 years) were enrolled in our study. The average duration of treatment with abobotulinumtoxin was 6.4 years (5 to 8 injections with mean interval of 9.6 months). Prolonged treatment was associated with decrease in effective dose or increased duration of action. Dose coeffi- cient decreased significantly (p<0.005).Conclusion. Multiple injections of abobotulinumtoxin for at least 3 years were associated with reduction in effective dose or increase in duration of action.