THE PHENE ANALYSIS OF CONNECTIVE TISSUE DYSPLASIA SYNDROME IN CHILDREN AND THEIR RELATIVES
60 families were examined: probands and relatives of I, II and III relation degrees. The family selection was carried out according to the proband (children at the age of 3-6) with the echocardiographic signs of mitral valve prolapse and/or anomalously located chorda. The results of examination of 360 people (61 -proband, 123 -relatives of the I relation degree, 172 -relatives of the II relation degree, 4 -relatives of the III relation degree) showed that the hereditary nature of connective tissue dysplasia with prevalence of so-called «maternal effect» was established in most cases. The high occurence of external mesenchymal signs in children can be explained by the genetic material storage across the generations.