The Frequency of Mutations in Gene Promoter eNOS T786C in Patients with False Joints of Long Bones: Relationship with Homocysteine Level and Inflammatory Mediators
The paper presents the comparative results of the prevalence of eNOS gene promoter mutation T786C in 130 patients with false joints of long bones and in those with consolidated fractures. It is found that the frequency of occurrence of the C-allele in patients with false joints was 1.35 times higher than for people with consolidated fractures. ENOS gene promoter mutation T786C was associated with the development of hypoplastic and aplastic types of false joints, increase in the proportion of persons with hyperhomocysteinemia, elevated inflammatory mediators, development of neurodystrophic syndrome and refractures.