INFLUENCE OF THE SCAFFOLD WITH MESENCHYMAL STEM CELLS ON RAT REPAIR AFTER PROLONGED EXPOSURE TO VIBRATION AND NOISE
This study has been devoted to the experimental substantiation of possibility to correct violations caused by prolonged exposure to elevated levels of total vibration and noise with the help of implantation of nonwoven biodegradable polylactide scaffold carrying autologous mesenchymal stem cells of the bone marrow. The procedure of exposure of the rats to vibration and noise has been performed daily for 1 hour for 30 days with the help of the vibration platform generating total vibration of vertical direction with frequency of 35-40 Hz and noise of 94 dB. The received results have demonstrated normalization of the levels of corticosterone and neuron-specific enolase in serum after injection of mesenchymal stem cells in the rats on the background of exposure to prolonged vibration and noise. In the structure of the target organs (adrenal glands, cerebellum, femoral muscle) have been registered minimal positive changes.