Aspirin and statins: possibilities for joint improvement of prognosis in cardiovascular disease
Today, cardiovascular diseases (CVDs) are the main cause of death in all countries of the world, which is largely due to the low adherence of patients with CVDs to treatment. According to the RECVASA register, the average adherence of patients of one of the polyclinics in the city of Ryazan to treatment (n = 1,165) in 2012 was 62.4%, adherence to beta-adrenergic blocking agent (BABs) was 70.8%, to angiotensin-converting enzyme inhibitors (ACEs) – 62.2%, to angiotensin II (ARB) receptor blockers – 57.1%, to statins – 46.8%, and to antiplate agents – 70.0%. The average adherence to treatment in survivors of the same group (n = 918) in 4 years in 2016 was significantly lower (p<0.001) and amounted to 47.8%. Patient adherence to BABs, ACEs also became statistically significantly lower (p<0.0001), at 43.8% and 50.0%, respectively; adherence to ARB was statistically insignificantly lower by 3.6% compared to the original level. The highest level of adherence to the use of antiplatelet agents was 63.9%, although it was significantly lower compared to the initial data (p = 0.0037), and the initially low adherence to the use of statins for 4 years has statistically significantly decreased (p<0.0001) and amounted to only 28.2%. The data obtained determine one of the possible ways to increase adherence to statins a fixed combination of them with other drugs affecting the prognosis, such as antiplatelet drugs.