Influence of Bile Sorbtion on the Tumor Necrosis Factor and Endotoxemia Changes
73 periampullary malignant tumor patients complicated with obstructive jaundice are investigated. At the same time we investigated middle mass molecules (MMM) and tumor necrosis factor-α (TNF-α) in serum and bile after percutaneous choagiostomy. Application of bile sorbtion (BS) leads to the MMM concentration decrease from initial level on 42.9versus 24.7% in controlled group. In control group TNF-α serum concentration after external bile duct drainage decreased on 62.7%. Besides at the same terms of observation TNF-α concentration in bile has decreased on 82.2%. In the basic group of patients BS application promoted to serum TNF-α concentration sharp decrease on 82.5 %, and in bile it decreased on 90.6% from an initial level. Application of BS promoted to increased allocation of MMM and TNFα from the bile and that diminished endogenous intoxications.