PHARMACOPEAN ANALISYS OF TABLETS OF DIETHYLETHANOLAMINE DERIVATIVES
Diethylethanolamine derivative tablets, manufactured by direct compression, do not possess adequate quality attributes. Granulation of excipients makes it possible to improve the fluidity of the mixture and increase the shelf-life of tablets, however the organization of the technological process in production is expensive. Melt extrusion makes it possible to increase the stability of the substance and obtain high-quality tablets with a shelf-life of 2 years. This technological approach is preferred for obtaining granulates from a hygroscopic substance of a diethylethanolamine derivative.