Alloplant biomaterials as postburn skin scarring inhibitors
Allotransplants for eyelid frame plasty by “Alloplant”® may facilitate recovery of eyelid anatomical position and function and prevent postburn scar tissue traction. Purpose of the study. To determine the level of fibrogenic factors after skin burn wound treatment with Alloplant biomaterials in experiment. The tissue level of TGF-β1 and FGF-1 fibrogenic factors was detected immunohistochemically in 84 Wistar rats treated with Alloplant biomaterials for skin burn wounds. It was established that the tissue level of fibrogenic cytokines reduced significantly after treatment with allogenic biomaterials that leads to inhibition of fibroblast proliferation and prevents excessive collagen synthesis. At tissue reparation, allogenic biomaterials inhibit coarse scar formation.