Comparative efﬁcacy of bisphosphonates in therapy of postmenopausal osteoporosis
3-year monitoring of three groups of women with postmenopausal osteoporosis was made in the rheumatological cabinet of the Medical Department of the Ministry of the Interior of Russia in the Ulyanovsk Region. The patients were treated with bisphosphonates of 2 generations – Ibandronic Acid (orally or parenterally) and Alendronic Acid (orally). The data on dual-energy x-ray absorptiometry (DXA) of an axial skeleton (bodies of lumbar vertebrae and proximal femur) was a criterion of antiosteoporosis therapy efficacy. The examination was made with apparatus “GE Lunar Prodigy Vision 4”. The metabolic bone markers (osteocalcin and bone alkaline phosphatase) were studied during the whole monitoring quarterly.