INCREASING OF ANTINEOPLASTIC EFFECT OF X-RAY IRRADIATION IN MICE WITH TRANCPLANTED MELANOMA B16F10 BY USE OF GADOLINIUM CONTAINING DRUG
The possibility of increasing antineoplastic efficacy of X-ray irradiation by use of MRI contrast drug Dipentast® was studied in mice with transplanted melanoma B16F10. Dipentast® is 0,5M water solu- tion of sodium gadopentetate and it doesn't possess intrinsic antitumor effect. Mice male (СВАхС57Bl)F1 with transplanted melanoma B16F10 were used in the study. Irradiation was per- formed with X-ray machine with nominal anode voltage 150 kV. Experimental and irradiated control groups were irradiation with dose of 20 Gy. Mice in experimental group were administered with0,175 ml of Dipentast® per 1 cm3 of tumour directly in to the tumour with a single injection right before the irradiation. Tumor growth rate observation showed that Dipentast® administration prior X-ray irra- diation leads to significant tumour growth delay (15±1 days) in comparison with irradiated control group (8±1 days).