Alteration of Effector Activity of T-Lymphocytes in Mice Immunized against Tularemia, Using <I>in vitro</I> Stimulation by Tularin
It has been shown that tularin contains antigens that specifically interact with antibodies of sera of mice vaccinated with <I>F. tularensis</I> 15 NIIEG (15 <sup>th</sup> line of production, Research Institute of Epidemiology and Hygiene). Besides, it has been established that tularin specifically intensifies expression of CD69 receptor on the surface of CD4 <sup>+</sup> and CD8 <sup>+</sup> subpopulations of T-lymphocytes, and specifically enhances synthesis of IFN-γ and FNO-α cytokines by means of T-helpers (CD3 <sup>+</sup> CD4 <sup>+</sup> lymphocytes) isolated from mice, immunized against tularemia. Put forward is the proposition to use tularin in serological surveys and reactions <I>in vitro</I> for identification of postinfectious or postvaccinal immunity to tularemia.