METHODICAL FEATURES OF THE APPLICATION OF MORRIS WATER MAZE FOR ESTIMATION OF COGNITIVE FUNCTIONS IN ANIMALS
In order to estimate toxic effects of nanoparticles on the brain we review the possibilities of using the Morris water maze to detect impairments of cognitive functions. Besides, the model experiment showed that individual variability of animal behavior significantly affects the results of water maze. The pre-selection of individuals is justified as a required measure to reduce such influence. We suggest using the type of behavior that each individual demonstrates in the test as a criterion for pre-selection.