Epidemiologic and populational aspects of myasthenia gravis in the Krasnodar Region
Objective: to study epidemiological and population indicators of myasthenia in the Krasnodar Territory. Materials and methods. 344 patients with a diagnosis of myasthenia living in the Krasnodar Territory underwent a retrospective analysis. Results. On January 1, 2017 the prevalence of myasthenia was 8.1 cases per 100,000 population, morbidity in 2011–2016 ranged from 0.27–0.71 cases per 100,000 population, and the average was 0.52 cases per 100,000. The average age of manifestation of the disease of registered patients was 46.2 ± 0.97 years. The minimum age of debut of the disease was 11 years, the maximum – 80 years. The ratio of men and women among patients with myasthenia was 1:2.5. The peak of the onset of the disease in women falls on the period of 20–40 years. A bimodal pattern of incidence in women was revealed in the period from 20 to 40 years and from 50 to 70 years. After 60 years 35 % of men fell ill. The generalized form of myasthenia was observed in 82.8 % of patients, eye cases in 16.3 %, oculopharyngeal form in 0.9 %. Of the observed patients, rural residents accounted for 58.7 %, urban residents for 41.3 %. Conclusion. The main epidemiological indicators of myasthenia obtained in the course of the study in the Krasnodar Territory are on average comparable with the Russian ones and meet the global trends. Epidemiological monitoring of myasthenia is more effective on the basis of specialized myasthenic centers.