Cervical cancer against the background of anembryonic pregnancy
Cervical cancer takes the first place among pregnancy-associated tumours. The processes of changing the cervical epithelium that is the most sensitive to human papillomavirus (HPV) in the period of metaplasia period are activated during pregnancy, and the changes of the hormonal background influence HPV replication and increase the rate of metaplastic changes. A clinical case is presented that might be interesting in several aspects: first, as has been shown, in this case chorionic trophoblast was a target for HPV, and affection of the latter resulted in miscarriage of a pregnancy, which was confirmed by testing of abortive material for detection of DNA of HPV type 16 - high viral load. Besides, specificity of the clinical course of cervical cancer against the background of pregnancy is an important factor. As has been found, with minimal invasion immediately in the cervix (microareas of squamous cell carcinoma without keratinization with perifocal dense lymphoid infiltration and invasion to 3 mm), there is metastatic involvement of iliac lymph nodes. This significantly influences the prognosis of overall and metastasis-free survival.