METHODS FOR EARLY DIAGNOSIS OF PARKINSON’S DISEASE
Currently, the diagnosis of Parkinson’s disease is carried out mainly on the ground of clinical picture. However, long before the development of motor disorders, a number of signs characteristic of parkinsonism can be detected. The review of the literature presents methods to detect non-motor disorders that can be considered as predictors of the disease and it also discusses the issue of the laboratory studies of specific biomarkers for early diagnosis. We suggested to use the combination of olfactory test and questionnaire about vegetative disorders as the most relevant solution for clinical practice. It is recommended to interpret the test data as a sign of extremely high probability of the development of clinical manifestations of Parkinson’s disease, and, therefore, as a reason to start preventive therapy.