Thetagamma phaseamplitude coupling: physiological basics, analysis methods, and perspectives of translation into clinical practice
Studying rhythmic neural synchronization (crossfrequency coupling in various ranges) is an emerging topic in presentday neurophysiology. One of the beststudied crossfrequency couplings is thetagamma phaseamplitude coupling that contributes to the cognitive function and may vary in patients with several conditions associated with cognitive impairment. Changes in thetagamma coupling can be registered in a wide range of diseases associated with cognitive decline. The review covers the physiological basics of thetagamma coupling, its registration and calculation, correlation with cognitive test results in healthy volunteers, and changes in patients. We have discussed the results of the preliminary studies of frequencydependent noninvasive brain stimulation based on thetagamma coupling.