Transcranial electrostimulation and electrophoresis of serotonin in complex treatment of chronic obstructive pulmonary disease
The work substantiates the feasibility of using transcranial electrostimulation for the activation of opioidergic system and stimulation of syntoxic adaptation mechanisms in order to synergistically improve the results of treatment of chronic obstructive pulmonary disease. The importance of endogenous mediators, cytokines in the formation of adaptation mechanisms is shown. The degree of participation of pro-inflammatory and anti-inflammatory mediators (interleukins 1,4,6,10 as pro-inflammatory, and interleukins 2,12 as anti-inflammatory) is determined. The importance of such neurotransmitters as serotonin, GABA, dopamine is confirmed. The authors studied the results of examination and treatment of 126 people with chronic obstructive pulmonary diseases, divided into 2 groups - 84 (main) and 42 (comparison group). In both groups, basic therapy was conducted in accordance with standards. In the main group, a transcranial electrostimulation and electrophoresis of serotonin in addition to basic therapy were performed. The state of coagulation and anticoagulation systems, oxidative and anti-oxidative systems, changes in the hormonal composition of the blood, and the function of external respiration were studied. During the activation of adaptation programs involved an appropriate unit (syntoxic or catatoxic), but their reciprocal relationships aimed at achieving the global goal of the whole organism. The processes of self-regulation can be modified and directed to achieve a predictable result with the help of certain external influences that activate the necessary adaptation programs. The article shows the activation of the anticoagulant system, the antioxidant activity of the blood, as an indicator of the activity of syntoxic adaptation mechanisms. This work determines the feasibility of incorporating thermal and electrophoresis of serotonin in the comprehensive treatment of COPD.