SOME ASPECTS OF DAMAGE OF THE LIVER IN DYNAMICS OF TREATMENT OF LYMPHOMAS
Biochemical research with an assessment of 4 main syndromes of damage of a liver before and after carrying out polychemotherapy (PHT) and achievement of the kliniko-hematologic remission (KHR) is executed. 151 patients with lymphoma are inspected (111 patients with non-Hodgkin`s malignant lymphomas (NHML) and 40 patients with the lymphoma of Hodgkin’s (LH). From them at 15 patients before and after treatment the cytokines profiles (FNO-α, IL-4) and the index FNO-α / IL-4 was investigated. Average age of patients in subgroup of LH made 32,8±2,4 years, in subgroup of NHML – 54,4±1,11 years. Prior to treatment the syndrome of a mesenchymal inflammation had the largest frequency: it was diagnosed for 44,5% of patients at the I–II stage of a disease and for 62,6% - at the III–IV stage, after treatment - for 23,8% and 37,3% respectively. Increase in contents as pro-inflammatory cytokines (FNO-α), and antiinflammatory cytokines (IL-4), and also the index FNO-α / IL-4 is initially diagnosed that is regarded as a cytokines imbalance. After treatment reduction of degree of a cytokines imbalance by 3 times is noted, however, normalization of the cytokines profiles was not noted. Lack of normalization of a biochemical and the cytokines profiles is the indication for carrying out a complex of rehabilitation actions.