GENDER CHARACTERISTICS OF QUALITY OF LIFE OF ADOLESCENTS - FOLATE CARRIER GENE CYCLE
The material for the study of gender-specific quality of life and carrier polymorphisms in genes of folate cycle based on data from a survey 762 adolescents (412 boys and 350 girls) aged 15-16 years. Results of the study of adolescents in quality of life and the carrier gene polymorphism MTHFR (677C>T; 1298 A>C), MTR (A2756G A>G), MTRR (A66G A>G) leads to the following conclusion: the girls frequency of gene polymorphism A2756G MTR in the homozygous state and gene MTRR A66G polymorphism in the heterozygous state was significantly higher than that of adolescent boys. Gender characteristics of quality of life parameters (prevalence figures for boys) have been installed in carriers of alleles 677T and 677S gene MTHFR. Leveling the gender features found in adolescents with the presence of a genotype 677T/T allele of MTHFR gene and 1298S gene MTHFR, which can be regarded as a consequence of the negative impact on quality of life.