ASSOCIATION OF GENETIC MARKERS WITH THE DEVELOPMENT OF METABOLIC SYNDROME AMONG YOUNG RESIDENTS OF THE NORTH
The goal is to study was to identify possible associative links between gene polymorphisms and components of the metabolic syndrome in young indigenous and non-indigenous people of the northern region. As part of the study, 834 young people aged 18-44 years (mean age 36.62 ± 5.12 years) were examined, of which 695 patients with metabolic syndrome (MS) and 139 healthy young people with normal body weight and without metabolic disorders. The frequency of rs1801133 genotypes of the MTHFR gene among MS patients was SS - 54.1%, CT - 36.1%, TT - 9.8%. Carrier of T allele associated with the risk of cardiovascular development diseases was in 27.8% of all examined patients with MS, the carrier rate of the heterozygous genotype TG rs1378942 of the CSK gene was 50.3%, homozygous carriage of GG - 20.4%, TT - 29.3%. Among patients with abdominal obesity the frequency of carriers of the heterozygous genotype TG rs1378942 of the CSK gene was 50.3%. An association of arterial hypertension (AH) with a carrier of the mutant T rs1801133 C677T allele of the MTHFR gene (OR 1.367, p = 0.047) was detected. The carriage of the TT genotype rs1378942 of the CSK gene is associated with hypertriglyceridemia (OR 2.018, p = 0.09).