Technological aspects for usage of Cyclodextins in manufacturing of herbal drugs
In the paper review of literature and patent sourc- es devoted to usage of cyclodextins in technology of dosage forms is presented. The main attention is paid to herbal medical products. It has been focused on theoretical aspects of cyclodextrin drugs elaboration, their range, advantages and disadvantages. Limi- tations for cyclodextrin use in certain dosage forms have been pointed on. Main technological approach- es for cyclodextrin-drug complex formation and fac- tors influencing its efficiency have been discussed. It has been found that most of groups of herbal bio- logically active substances (essential oils, fats, flavo- noids, coumarins, alkaloids, phenolic compounds) are to be successfully included into cyclodextrin complex- es in order to improve their bioavailability. But at the same time it’s necessary to elaborate complex forma- tion technology specific for a certain active pharma- ceutical ingredient.