Characteristics of glucose metabolism in women with arterial hypertension: influence of age and the level of follicle-stimulating hormone
<i>The lack of estrogens, arterial hypertension (AH) and hyperglycemia are key factors of pathogenesis of cardiovascular diseases in women. Objective: to study the peculiarities of glucose metabolism in patients with AH depending on age and level of follicle-stimulating hormone (FSH). Methods: prospective study included 126 women 35-60 years old with AH, 80 almost healthy women formed control group. Authors measured the level of FSH, glucose in peripheral blood, insulin and index of resistance HOMA-R. Results: young healthy women with the level of FSH </i>≥<i> 30 mME/ml had higher levels of basal glycemia (3.94+0.80 and 3.40 ± 0.54 mmol/l correspondingly; р = 0.013) and index HOMA-R - median 1.27 (0.15; 1.53) and 0.89 (0.10; 1.56) units correspondingly (р=0.087) compared to those with normal (< 30 mME/ml) level of FSH. Women with AH (both young and middle aged) with the level of FSH </i>≥<i> 30 mME/ml had higher levels of all insulin-glucose tests than in women from control group with comparable age. Patients 46-60 years old with FSH </i>≥<i> 30 mME/ml had the most significant symptoms of resistance to insulin - insulinemia 13.10 (2.43; 17.40) </i>μ<i>Units/ml and index HOMA-R 2.63 (0.49; 3.90) units (р = 0.008/0.032 compared to the women with the same age, AH and the level of FSH < 30 mME/ml). Conclusion: resistance to insulin is leading pathogenetic mechanism of forming AH in women after menopause, it realizes in younger women in presence of deficiency of estrogens.</i>