PATOGENETIC SUBSTANTIATION OF VARIOUS SCHEMES CORRECTION LIPID METABOLISM IN ACUTE PANCREATITIS
The paper presents the results of an experimental study of the effect emoxipine, verapamil and reamberin on changes in the qualitative and quantitative composition of the lipid tissue structures of the pancreas, the intensity of lipid peroxidation, antioxidant capacity, the activity of phospholipase A2, hypoxia in acute pancreatitis. It is shown that under the action of these drugs in the tissue structures of the inflamed pancreas is a decrease of the intensity of free-radical processes of lipid peroxidation, phospholipase activity, hypoxic events. The level of antioxidant defense organ tissue. In the first three days of observation, a clear tendency towards normalization of the lipid composition of the transformed tissue structures of the pancreas. Comparative analysis of the studied drugs showed that emoksipin discovered the ability to increase the stability of membranes pankreatotsitov to the pathological effects of molecular products of lipid peroxidation, verapamil – to the relief of activated phospholipases. Reamberin significantly reduces the processes in hypoxic tissue structures pancreas. Positive effect on the phospholipid composition of body tissue structures of the first two drugs was relatively higher.