THE INFLUENCE OF CYTOKINES ON THE CHANGE OF PEROXIDE LIPIDS OXIDATION AND ANTIOXIDANT SYSTEM INDICATORS: AN EXPERIMENTAL STUDY
The influence of native cytokines preparations (angeogenine, erithropoetines and substances of a recombinant factor of alpha tumor necrosis) on indicators of peroxide lipids oxidation and anti-oxidizing activity of blood plasma was established as a result of the experiment. The 1,2 times increase of anti-oxidizing activity of blood plasma is revealed in the experiment on rats at external use of substance of a necrosis factor of alpha tumor. According to the maintenance of average molecules in integral blood essential excess by 2,6 times in skilled group of animals in comparison with control is detected, reliability of distinctions between these groups is identified. Decrease in the indicators of the final products (the Shiff bases) was found during the use of the substances of alpha tumor necrosis factor. During the use of preparations «angeogenine», «erithropoetine» the reduction of indicators of an intermediate product HMM and anti-oxidizing activity of blood plasma are detected. The obtained data testify to a high activity of preparations of various cytokines even during the external application on intact derma in experimental conditions.