A Comparative Study into Antioxidant Activity of Fixed Combinations in Topical Glaucoma Treatment
The paper's purpose was to compare the antioxidant activity (AOA) of fixed combinations for topical glaucoma treatment. Dorzolamide/ timolol, brinzolamide/timolol, latanoprost/timolol, brimonidine/timolol and travoprost/timolol fixed combinations were tested in vitro using the model of oxidation-induced haemolysis. Antioxidant activity of dorzolamide/timolol - brinzolamide/timolol - latanoprost/ timolol - brimonidin/timolol - travoprost/timolol was 20-16-13-9-3% respectively. AOA of all fixed combinations increased while more drug was added into the model system, except for latanoprost/timolol. AOA of travoprost/timolol increased 10 times in 90 μl of the drug in comparison to 30 and 60 μl. Fixed combinations of carboanhydrase inhibitors with timolol have an advantage over other fixed combinations due to their high antioxidant activity. They may be used as direct neuroptotective agents in glaucoma treatment.