CHARACTERISTICS OF THYROID PROFILE IN PATIENTS WITH DIFFERENT CLINICAL VARIANTS OF GLOMERULONEPHRITIS
There are features of the thyroid function in patients with different clinical manifestations of glomerulonephritis (GN). The thyroid profile of patients with nephrotic and mixed GN is characterized by the elevated levels of thyroid-stimulating hormone (TSH) and antibodies to thyroid peroxidase (anti-TPO) in combination with the reduced levels of thyroxine (T4). In patients with the hypertensive form of GN there are also increased levels of TSH and anti-TPO, but the content of T4 is saved. The identified changes in the thyroid profile are correlated with the indicators of renal function, proteinogram and cytokine status. The thyroid dysfunction can be considered as one of the units of pathogenesis GN, it causes the development of edema, reduction of glomerular function in the nephrotic syndrome and contributes to the development of anemia in the hypertensive variant of the disease.