INTERACTION OF B-BLOCKERS WITH INHIBITORS OF THE PG-SYSTEM, KKS AND RAS IN THE RAT KIDNEY
To assess the role of the PG-system, KKS and RAS in the formation of renal effects of в-blockers in the interaction of propranolol with inhibitors of these neurohumoral systems in the rat kidney was investigated. The experiments were performed on anesthetized rats with catheterized posterior vena cava and urinary bladder to infuse saline and collect urine. Renal function was assessed on the basis of diuresis value, inulin clearance, potassium and sodium excretion and sodium /potassium ratio in urine. Propranol induced characteristic diuretic response in rats with simultaneous increase of sodium and potassium excretion with urine. Pre-administration of diclofenac-so-dium (PG-system inhibitor) or contrical (KKS inhibitor) did not alter the rat kidney reaction on propranolol. Pretreatment of animals with direct renin inhibitor - aliski-ren sharply enhanced diuretic, sodiumuretic and potas-siumuretic effects of propranolol. It is concluded that renal PG-system and KKS are not involved in the mechanism of renal effect formation of в-blockers. Renal RRS functions as modulator that prevents excessive loss of water and electrolytes with urine under the action of these drugs.