Changes of the immune status of patients with renal cell carcinoma in laparoscopic radiofrequency ablation
The quantitative assessment of absolute number of immunocompetent cells was conducted in peripheral blood in 29 patients with renal cell carcinoma (RCC) during treatment process: while 20 patients underwent laparoscopic radiofrequency ablation (RFA), 9 - laparoscopic resection of the kidney (LRK). In patients who underwent RFA during the month after the procedure there was observed a significant increase of activated T-helper cells and cytotoxic T-lymphocytes (p <0,05) while in patients who underwent LRK such changes were absent. Revealed dynamics of immunological parameters might indicate the activation of cellular immunity under the influence of RFA similar to observed during the process of active specific immunotherapy.