ROLE OF MATRIX METALLOPROTEINASES AND THEIR INHIBITORS AT ENDOMETRIAL HYPERPLASIA
The role of MMP-2 and MMP-9, TIMP-1 and TIMP-2 in the mechanisms of formation of endometrial hyperplasia (EH) and glandulocystic endometrial hyperplasia were detected. In EH and glandulocystic EH proteolytic activity MMP increases, an important factor is the decrease of the inhibitory effect of their specific tissue inhibitors – TIMP-1 and TIMP-2. Revealed a statistically significant correlation indices of MMP and TIMP, as well as their ratio depending on the shape of the ET – glandulocystica with clinical and morphological features suggest the possibility of using these parameters as markers of differential diagnosis between the two groups of women with glandulocystic EH and EH without cervical pathology. The results allow a differentiated approach on the formation of high-risk groups and to predict the outcome of the disease, to assess the proliferative processes in the endometrium, thus choose an adequate treatment strategy aimed to preventing the development of neoplastic transformation of the mucous membrane tissue of the endometrium in women depending on the form.