Hydrolysis of integrase of human immunodeficiency virus by catalytic antibodies against viral integrase
It was shown for the first time that IgG antibodies (Abs) from the blood of patients with syndrome of acquired human immunodeficiency (AID) efficiently hydrolyze integrase (IN) from the human immunodeficiency virus (HIV). Several rigid criteria were applied to show that IN-hydrolyzing activity is an intrinsic property of the polyclonal Abs from AIDS patients. It has been established that Abs in contrast to polyclonal canonical proteases, which hydrolyze all proteins, possess strict substrate specificity and efficiently hydrolyze only IN.