CONCEPTS OF THE GENESIS OF HPV-ASSOCIATED CERVICAL CANCER
Genesis of cervical neoplasia is caused by penetration of human papilloma virus in stem cells of epithelium of cervix uteri reserve and basal cells. Cervical intraepithelial neoplasia are transformed to cervix uteri cancer in 1 % of cases. The mutations of cellular genes mediated by virus proteins Е5, Е6, Е7, lead to genomic instability, inactivation of DNA reparation systems, to violation of the cellular cycle control and regulation of apoptosis, as well as to violations of intercellular adhesion. It is not possible to explain HPV-associated gene mutations only by the integration of HPV 16 genotype DNA into cellular DNA due to di erences in the physical status of HPV DNA in the tumor.