INTERCONNECTION OF ACE AND NOS3 GENES POLYMORPHISM WITH THE LEVL OF ARTERIAL PRESSURE AMONG ATHLETES OF THE SAKHA (YAKUTIA) REPUBLIC
The article presents the results of arterial pressure (AP) level study and polymorphism of genes of angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) analysis among sportsmen, who go in for different kinds of sports. Materials. 135 Yakut sportsmen (men, 22,3±4,2 years old; masters of sport and candidate masters of sport), who specialize in combat sports and cyclic kinds of sport. Research materials: scientific literature analysis and summarizing, monitoring, methods of mathematical statistics. Results. Prevalence rate of arterial hypertension (AH) analysis according to the results of daily monitoring of arterial pressure (DMAP) showed that 56 (41,5%) sportsmen had a high level of AP, 79 (58,5%) sportsmen had normal AP level. At the same time, no statistically valid dependence of AH on a kind of sport was revealed (χ2=3,48, df=1, p=0,062). Among people with a high AP level the carriership of allele D gene of ACE was 67,8% contrary to 48,1% of people with a normal AP level. Homozygous genotype ACE DD carriership was revealed among 25% of sportsmen with a high AP level and 11,4% of people with normal AP level. Statistical analysis showed that the chance of allele D carriership among examined sportsmen with AH is twice higher, than allele I carriership (95% Di Osh 1,1 - 3,7). Relative chance to have homozygous genotype DD is 2,5 times higher (95% Di Osh 1,03 - 6,5), than among the carriers of other genotypes. eNOS genotypes distribution deviates from Hardy-Weinberg balance. Conclusion. The received results correspond with the results of other research works concerning polymorphism of ACE gene influence on AP level among young people.