Cytomorphological quantitative featuresand nucleolar organizers of pancreatic adenocarcinoma
Clinical and radiological detection of tumors of the pancreas requires their morphological verification. The use of fine-needle aspiration biopsy significantly expands thepossibilities of obtaining material for cytological examination in a complex on the anatomic and topographic features body - podzheludochnoy gland. The authors studied cytomorphological signs of pancreatic adenocarcinoma by a specially developed "Scheme or a formal assessment of qualitative and quantitative composition of the tumor cells", consisting of 67 characters and their gradation characteristics cytoplasmic, nuclear and nucleolar structural components of the cells in the puncture specimens of 50 patients. The study of the cytogenetic features of tumor cells was carried out in 1500 nuclei Ag-positive cells - 7945 nucleoli adenocarcinoma cells. Studies have revealed Quantitative structural,cellular, cytoplasmic, nuclear, nucleolar characteristics and morphofunctional nucleolar types of chromosomal regions specific to tumor cell adenocarcinoma of the pancreas. Identified cytomorphological, cytogenetic and background components in the material of the punctates of tumors of the pancreas can be fundamental to establish the diagnosis of AK.