LOCAL TREATMENT OF PURULENT WOUNDS BY DINT OF MEDICAMENTOUS COMBINATION BASED ON POLYETHYLENE OXIDE
The article shows the results of the experiment on the model of purulent wounds using planimetric (percentage reduction in wound area, the rate of healing), histology (hematoxylin and eosin stain) and statistical methods. The experiment was performed in rats Wistar, which were divided into 3 groups (intact, control, experimental), 60 animals each. The combination of a test sample was applied, consisting of antiseptic and antibiotic immobilized on polyethylene oxide. Planimetric study showed that the percentage reduction in wound area in the experimental group was greater than the control at 5-15 days of observation, while the rate of healing in the experimental group was significantly (p ≤ 0,05) above 1.63 times, compared with control. After a histological study, it was noted that the regeneration rate was more and epithelialization occurs earlier in the experimental group than in the control. Thus, the results showed higher contact efficiency of the developed combination compared to intact and control groups.