Histochemical changes in the myocardium when exposed to chronic alcoholic intoxication
We have studied the histochemical activity of alcohol dehydrogenase, glucose-6-phosphate dehydrogenase, succinate dehydrogenase, acid and alkaline phosphatases and nonspecific esterases in the myocardium of experimental animals at chronic alcoholic intoxication. The experiment was carried out on 50 white non-linear male mice. The animals had been alcoholized for 3 months by a semi-voluntary method, 20 % ethanol being used as a sole source of liquid, which is optimal for creating a model of chronic alcoholism. The increased activity of alcohol dehydrogenase in cardiomyocytes was revealed. Total activity of succinate dehydrogenase in the tissues of the myocardium is reduced in comparison with the control. In most of the cardiomyocytes the activity of glucose-6-phosphate dehydrogenase was defined as linear deposits of diphormazane. Increased histochemical activity of alkaline phosphatase was detected in the walls of microcirculatory vessels. It was found that chronic alcoholic intoxication results in the change of metabolic processes in cardiomyocytes of the experimental animals, violation of cellular metabolism, which leads to damage of the myocardium.