BARRETT ESOPHAGUS AND ANTI-HELICOBACTER PYLORI ANTIBODIES
Aim. The aim of the study was to evaluate the risk factors and the role of Helicobacter pylori in development of Barrett esophagus in patients with gastroesophageal reﬂux disease, who work as police officers in Yakutia. Materials and methods. 78 male police officers with gastroesophageal reﬂux disease, including erosive and non-erosive types, being on examination and treatment at the Medical department of the Interior Ministry of the Russian Federation for the Republic of Sakha in 2017-2018 have been examined. The diagnosis was based on findings of classical clinical, endoscopic, morphological and immunological methods of investigation. Fibroesophagogastroduodenoscopy was performed for clinical diagnosis and for obtaining biopsies in accordance with the standards. Barrett esophagus was verified in esophagus biopsy samples as incomplete intestinal metaplasia. Anti- Helicobacter pylori IgA, IgM and IgG antibodies were determined by ELISA method (BCM Diagnostics). Results and discussion. The results indicate a high prevalence of Barrett esophagus in male police officers with gastroesophageal reﬂux disease in Yakutia. According to our study significant risk factors for Barrett esophagus development are Caucasian race, leading position at work, the natives of Yakutia, as well as the hiatal hernia and erosive gastroesophageal reﬂux. Conclusion. A negative correlation was revealed (r=-0,319 at p =0,002) between the degree of mucosa affection at the distal part of the esophagus and the level of IgA specific anti- Helicobacter pylori antibodies.