Trace element status in children with bronchial asthma living in St.Petersburg
The objective. To study the trace element status of children with moderate bronchial asthma living in St. Petersburg and to assess the detoxification effect of the drug «Zosterin-ultra-60». Patients and methods. We examined 32 children (age - 10.12 ± 3.79 years), suffering from moderate bronchial asthma (BA); all were in the state of drug-induced remission and received basic anti-inflammatory therapy. Research methods included study of complaints, history of disease, general clinical examination, testing of external respiration function, full blood count, detection of total and specific IgE, chemical analysis of blood serum with detection of 34 elements by inductively coupled plasma mass spectrometry. Results. According to the findings of examination of the trace element status, in blood serum of children with bronchial asthma living in St. Petersburg silicon deficiency was found in 100% of cases. Simultaneously, about one third of patients had iodine, phosphorus and selenium deficiencies. In 10% of cases sodium, calcium and copper deficiencies were noted. At the same time, 40% of patients with moderate bronchial asthma had enhanced levels of iron and zinc, one third - of copper, chromium and vanadium. As has been found, the use of «Zosterin-ultra-60» for 10 days 1 time daily at night promotes a decrease of the average levels of such trace elements as cadmium, molybdenum, magnesium, calcium, lead, potassium, silicon and germanium together with a significant increase of the average levels of cobalt, sodium and phosphorus. Conclusion. Reduction of the amounts of toxic metals in blood, absence of undesirable effects permit to use the absorbent «Zosterin-ultra-60» in complex treatment of BA in children living in ecologically unfavourable areas of megalopolises.