ANTICONVULSIVE EFFECTIVITY OF IMPULSE MAGNETIC FIELDS ON PICROTOXIN SEIZURES MODEL
The article contains the results of the study of anticonvulsive effect of low-intensity impulse magnetic fields on the picrotoxin seizures model. The experiments were performed on outbred male mice. The Picrotoxin («Sigma», USA) was injected in a dose of 2.5 mg/kg subcutaneously five minutes later after the repetitive transcranial magnetic stimulation (rTMS) or the placebo. The regimes of rTMSvariated in frequency (0.1, 0.3, 0.5, 1.0 and 10 Hz), intensity (10, 20 и 40% of maximal magnetic induction (MMI) of the ring coil) and the number of the procedures (1, 3, 10).The dependence of the reduction of the criterial characteristics from rTMS parameters on that convulsive model was revealed. The repetitive transcranial magnetic stimulation in all the regimes of exposure decreased the number of the seizures on the picrotoxin model in 1.5-2 points (р<0,005) with the dominant effect of a tenfold stimulation. The anticonvulsive effect of rTMS on that model depended on the impulses frequency, the intensity and the number of the procedures. The exposure with 0.5-1.0 frequency and 20% of MMI intensity was more effective (р<0.01).