PATHOGENETIC ASPECTS OF DEVELOPMENT OF ARTERIAL HYPERTENSION IN COAL WORKERS
We carried out gistomorphometrical researches of vessels of the small circle of blood circulation in the pulmonary tissue of 17 miners which had worked under dust conditions on the average 14,1 ± 0,5 years. They were considered as healthy according to the results of dynamic observation and they perished due to technogenic catastrophe. The results showed that the thickening of the endothelial layer, the hypertrophy of smooth muscle structures and the development of perivascular sclerosis are happened in the vessels of the lungs of miners. Changes of the structure of the vessel wall lead to its thickening and reduction the lumen of the vessel, that creates conditions for the development of pulmonary hypertension. The hypertrophy of smooth muscle structures is considered as one of the manifestations of systemic coniotic processes, which occur in the wall of the pulmonary vessels and consequently causes a further increase in blood pressure that has secondary character. The obtained results dictate the need to develop methods of early monitoring of the cardiovascular system in coal workers to detect latent and the initial stages of pulmonary hypertension.