LONG TERM TREATMENT WITH BISOPROLOL AND NEBIVOLOL IN PATIENTS WITH IHD COMBINATED WITH COPD: A COMPARATIVE CHARACTERISTICS INFLUENCING ON ARRHYTHMIA FREQUENCY, QUALITY OF LIFE AND BRONCHIAL OBSTRUCTION SYNDROME
In order to determine the comparative effectiveness of long-term administration of bisoprolol, and nebivolol in 150 patients (middle age - 45-75 years) with ischemic heart disease (IHD) in the form of stable angina second functional class (FC II), accompanied with chronic obstructive pulmonary disease (COPD) stage II-III. We compare and define the changes in frequency of arythmie complications, quality of live and spirometry at the bigining and at the end of treatement (after 4 months). With these we definined 2 groups, 1 group of 75 patient were given bisoprolol and the others 75 were given nebivolol. We etablished a significant antiarrhythmic and antianginal effects of both bisoprolol and nebivolol, which was accompanied by improvement in the quality of live and the absence of negative impact of COPD. It is noted that these effects are more pronounced in the case of monotherapy with bisoprolol compared with nebivolol. As a result of the study it’s recommended that it’s preferable to use bisoprolol in case of stable angina of second (FCII) which is accompanied by COPD of stage II-III and complicated with ventricular arythmie.