Effectiveness of specific immunotherapy and interrupted hypobaric adaptation in the treatment of children with allergic diseases
This article indicates the results of effectiveness of specific immunotherapy (SIT) and hypobaric adaptation in the treatment of children with allergic diseases. We have revealed the decrease of IL-4 and IL-6 (p <0,05), IgE and TNF-α (p <0,1) in 70% of children after SIT course in the hospital, that can demonstrate the switch of immune response from Th2-type to Th1-type after 2 weeks of respective treatment. However, 30% of patients after SIT had increased concentrations of IL-6 and TNF-α (p <0,05), IgE total (p <0,1), that suggests to select such patients for possible future immunomodulatory therapy. We have also found out a significant reduction of the concentration of IL-4 (p = 0,048) in children with allergic diseases after completing the course of hypobaric adaptation (n = 15). The increase of serum levels of IL-6 and TNF-α haven't been observed after the treatment.