INVESTIGATION OF THE DIURETIC PROPERTIES OF A NEW SYNTHETIC SUBSTANCE
The paper gives the results of designing a safe synthetic diuretic agent whose advantages are a combination of synthetic and herbal diuretics. The new phenolglycoside compound 4-carboxyphenyl-o-D-glucopyranoside sodium salt was produced by organic synthesis via glycosylation catalyzed by boron trifluoride etherate. The structure of the resultant glycoside was identified by NMR spectroscopy The animal experiments were carried out to investigate the diuretic properties of the new compound versus the known diuretics furosemide and arbutin. Its diuretic activity was assessed from the volume of excreted urine where the levels of sodium and potassium ions were measured. 4-carboxyphenyl-o-D-glucopyranoside sodium salt was found to have a mild diuretic effect unassociated with the urinary excretion of electrolytes.