Role of molecular genetic factors in pathogenesis and diagnosis of non-alcoholic fatty liver disease (literature review and own data)
Non-alcoholic fatty liver disease is the most common liver disease, which usually has a benign course. After the occurrence of steatohepatitis the risk of developing fibrosis, cirrhosis and hepatocellular carcinoma significantly increases. At the moment, there are no reliable predictors of the aggressive course of this patients’ disease, but genetic aberrations are the most promising predictor markers. This article devoted to the role of the PNPLA3, TM6SF2, SERPINA1 and HFE genes in the pathogenesis and course of non-alcoholic fatty liver disease. Data of the prevalence of pathological alleles of these genes among patients living in St. Petersburg is also included.