Fibroblasts as a Model for Studying Molecular Mechanisms of Immunopathgenesis of Viral Infections and Immunotropic Drugs
The role of primary fibroblasts and diploid cell lines of human fibroblasts in the generation of antiinfectious immunity is analyzed. The adequacy of the cellular model based on fibroblasts for studying the molecular mechanisms of immunopathogenesis of viral infections is considered, as well as the possibility of using fibroblasts to study the specificity of immunotropic drug action. Prospects of the model based on certified lines of diploid fibroblast cells to study mechanisms of action of new and known immunomodulators are discussed.