PATHOGENETIC SUBSTANTIATION OF PHARMACOLOGICAL PROTECTION OF ANTIOXIDANT SYSTEM IN TISSUES OF IONIZED RATS
Chronic γ-irradiation at a total dose of 1,5 Gy leads to inhibition of the functional activity of glutathione section in organism antioxidant system. Heptral injections course given to exposed rats resulted in a positive effect even after 24 hours. On the 15th day the concentration of reduced glutathione in thymus and spleen, increased by 30,7% in comparison with the control, while the activity of the glutathione enzymes was significantly higher than that of the control. Thus, the course injections of heptral leads to normalization of the glutathione redox system functioning in exposed animals. Heptral can be used in multimodality therapy of low-intensity radiation damage at low doses.