STUDY OF ANTIEXUDATIVE AND ANTIPROLIFERATIVE ACTIVITY OF EXTRACTS OF HEDYSARUM FRUTICOSUM
The aim of the study was to assess the antiexudative and antiproliferative activity of aqueous and alcoholic extracts of Hedysarum fruticosum. We developed and prepared aqueous (infusion) and alcohol (tincture) extract of Hedysarum fruticosum. In the model of formalin edema created by the inflammatory response in white males rats of the Wistar line. For the severity of the antiexudative action of the investigated extracts we selected the dose of 25 ml/kg of the reference drug and acetylsalicylic acid (ASA) at the dose of 300 mg/kg. The antiexudative effect was studied after 3, 24, 72, 120, 168 hours after the administration of flogogen. The results showed that the inflammatory response was formed within 3 hours, peaked in the first day and continued for 7 days. The most pronounced anti-inflammatory effect was observed when introducing the tincture with 70% ethyl alcohol. The infusion and tincture of 40% ethyl alcohol have a less pronounced anti-inflammatory effect. Antiproliferative activity of the investigated extracts was studied on the model of the "cotton granuloma". A pronounced activity compared to the drug (indomethacin) and reliable in comparison with the results obtained in the control group animals was showen by the infusion prepared in the following ratio of raw material/extractant: 1:1.