ETIOLOGY, MECHANISMS OF REGULATION OF THE MORPHOFUNCTIONAL STATE OF THE ESOPHAGUS AND PATHOGENESIS OF CHRONIC ESOPHAITIS
Taking into account the action of endogenous and exogenous risk factors, to discuss mechanisms for regulating the morphofunctional state of the esophagus and the pathogenesis of HE at the cellular, intercellular, organ and systemic levels. The work is based on the analysis of literature data and the results of long-term studies of the author and employees of the Department of faculty therapy, conducted in 689 patients with clinical and morphological manifestations of HE. 124 of them were treated for GERD with reflux esophagitis (re) associated with chronic gastritis (CG), 129 for GERD and re due to biliary pathology, 181 for exacerbation of CG, 223 for recurrence of peptic ulcer disease (NAF) and 32 for non-comorbidities. Among patients with GERD and re in Association with CG, there were 61 males and 63 females, aged 30-60 years, and with GERD and re in biliary pathology, 42 males and 87 females in 86% of cases. Pathogenesis of the disease in the detection of risk factors associated with the violation of the regulatory systems of the body and interaction at the cellular, intercellular, organ, organ and systemic levels, leading to a decrease in multi-level protection mechanisms and the development of morphofunctional changes in the esophagus.