Gene regulation of telomere length in human peripheral blood lymphocytes in early and remote perods after irradiation
Radiation-associated violations of gene regulation of lymphocytes telomere length in early and late period after exposure are investigated. In Chernobyl clean-up workers in the range of doses more than 500 mSv was set reduction of relative telomere length and imbalance in TERF1, TERF2 gene expression on the background of p53-mediated activation of telomerase activity. The early period after professional exposure in“Shelter” object characterized by impairment of protective function of telomeres