BIOMARKERS OF DESTRUCTIVE PROCESSES IN SERUM OF SCHIZOPHRENIC PATIENTS
The aim is the investigation of biological markers in the serum of patients with schizophrenia. The study involved 155 schizophrenic patients receiving treatment in a psychiatric hospital and 50 healthy people matched for sex and age. It was determined the spectrum of molecules medium mass, as an indicator of endogenous toxicity, concentration of antibodies to native and denatured DNA, cortisol, dehydroepiandrosterone sulfate (DHEA-S) and glutamate in blood serum. We found an increase in the concentrations of all biomarkers in the serum of schizophrenic patients compared with healthy persons. This indicates a pronounced imbalance in homeostatic processes and the development of destructive processes in schizophrenia. Increasing the concentration of neurosteroid DHEA-S is probably a protective compensatory reaction to increased levels of cortisol. Detection of the complex neurohormonal biomarkers can contribute to the understanding of the metabolic abnormalities associated with the pathogenesis of the disease and allow the use of the identified features for a personalized approach to therapy.