MORPHOFUNCTIONAL FEATURES OF THE HEMATO-ENCEPHALIC BARRIER AND POSSIBLE WAYS TO BYPASS IT WITH THE HELP OF PHYSICAL AND PHYSICO-CHEMICAL FACTORS (REVIEW)
The data on the problem of availability of drugs in the treatment of brain diseases and other related diseases due to the presence of the blood-brain barrier are presented. The analysis of the morphofunctional and structural components of BBB, as well as the features of the mechanism of transport of drugs through them, is conducted. The possibilities of using ozone/NO-ultrasound technology (method) for the introduction of drugs directly into the nervous tissue with minimal spread throughout the body bypassing the BBB, which is a new approach to solving the problems of resistance of the Central nervous system to drug therapy.