THE POLIMORPHISM OF HEMOSTASIS SYSTEM GENES IN YOUNG AND MIDDLE AGE PATIENTS WITH ISCHEMIC STROKE AND CONSTITUTIONAL VENOUS INSUFFICIENCY
The polymorphisms of the hemostatic system genes in young and middle age patients with ischemic stroke (IS) and constitutional venous insufficiency was studied. Polymorphic variants of candidate genes of ischemic brain lesions described in the literature were chosen for the research: polymorphism 20210G>A FII gene, polymorphism of 1691G>A FV gene, polymorphism-455G>A FGB gene, polymorphism-6755G>gene 4G PAI-1, polymorphism 807C>T ITGA2 gene and polymorphism T>ITGB3 gene. Concluded that genetic susceptibility to thrombophilic conditions plays a large role in ischemic stroke in young and middle age patients. The association of polymorphism 20210G>A gene FII, 1691G>A FV gene («Leiden mutation»), 675 5G>4G the PAI-1 gene with the development of IS in young and middle age patients with constitutional venous insufficiency was found. Gene polymorphism of the fibrinogen 455 G>A on the contrary was more frequent in patients with IS and without symptoms of constitutional venous insufficiency.