OPTIMIZATION OF THE PRODUCTION AND SYNTHESIS OF THE RADIOPHARMACEUTICAL 18F-FET IN KAZAKHSTAN FOR THE DIAGNOSIS OF BRAIN TUMORS
This article presents the results of research work of the authors for the production, synthesis and clinical application of a new radiopharmaceutical for Kazakhstan – 18F-fluoroethyltyrosine (18F-FET) with the use for diagnosis by the method of PET/CT. The article describes in detail the techniques for the production and preparation of the radiopharmaceutical. It has been pointed out in the article, that the production and synthesis of 18F-FET, its high stability in the body, fast kinetics of accumulation in the brain and the tumor, its low accumulation in non-tumor tissue, as well as ease of synthesis, determine further assessment of 18F-FET as amino acids indicator for cerebral and peripheral tumors.