PROSPECTS OF APPLICATION OF MOLECULAR BIOLOGICAL MARKERSIN PATIENTS WITH LOCALLY ADVANCED BREAST CANCER
The review contains current opinions on prognostic and predictive marker analysis of the disease, possible progression of the locally advanced breast cancer. Clinical-morphological, serum, immunohistochemical and genetic markers are discussed. The analysis of literature on the importance of tumor stroma, macrophages, condition of regional lymph nodes in predicting of overall and relapse-free survival is performed. Parallels between the significance of certain markers and possible ways of metastasis are given.