THE METHOD OF SIMULATION OF POSTINFARCTION CARDIAC INSUFFICIENCY IN SMALL LABORATORY ANIMALS
Postinfarction cardiac insufficiency was simulated experimentally on small laboratory animals (mice). To confirm chronic cardiac insufficiency echocardiographic method, macro- and microscopical methods were used and the activity of natriuretic peptides gene in cardiomyocytes was determined. The scar tissue in the infarction area, significant difference in ratio index between end-systolic and end-diastolis area of the left ventricle of the heart between experimental and control groups of animals as well as more than ten-fold increase (p<0.001) in natriuretic peptides in the experimental group of animals in comparison with controls was revealed.