POSSIBILITIES OF MEDICAMENTAL CORRECTION OF ADAPTATION DISORDERS CAUSED BY NEPHRECTOMY
Background. The aim of the experiment among 240 male inbred laboratory rats was to study the effect of nephrectomy on system adaptation reactivity and effectiveness of pharmacological correction of adaptation disorders by a new synthetic adaptogen Selanc. Materials and methods. To analyze the effect of nephrectomy on the total adaptive response of animals the authors used laboratory models of damaging loads of different nature: nephrotoxicants (mercury dichloride), physical factors (acute hyper (hypo) terms) and chemical (acute alcohol poisoning) nature normobaric hypoxia, extreme muscle stress and immobilization stress. In order to correct system adaptive disorders the researchers carried out single or course (within 14 days after nephrectomy) intranasal administration of the synthetic adaptogen based on bioregulatory peptides - Selanc. Results. The experiment showed that nephrectomy is a powerful stress, and existence of animals with one kidney can be interpreted as an expression of disadaptation stress, because after nephrectomy there were revealed significant disorders of adaptation reactivity of animals: 1.5 times reduced resistance to nephrotoxicants (mercury dichloride); resistance to hypoxia by 20 % ( p > 0,05); resistance to extreme muscle stress by 25 % ( p > 0,05); reduction in hyper (hypo) thermia tolerability in animals by 25 % ( p < 0,05); reduction of ethanol tolerance almost by a third ( p < 0,05); immobilization stress tolerance of 28 % ( p < 0,05) compared with the control group. A single administration of Selanc restored adaptive capabilities of animals to the level of healthy check by all parameters investigated, and after the course the capabilities were not significantly different from those of healthy animals. Conclusions. Selanc experimentally demonstrated expressed nephroprotective, antihypoxic, aktoprotective, anti-stress, termoprotective and adaptogenic features that can be applied in clinical practice.