THE LEVELS OF SEX STEROID HORMONES AND THE CORRESPONDING SPECIFIC ANTIBODIES IN THE SERUM OF HEALTHY WOMEN AND BREAST CANCER PATIENTS
The steroid hormones (estradiol, progesterone) and specific antibodies in the serum of 65 healthy women and 74 patients with breast cancer in postmenopausal women were investigated. Purpose – to identify the relationship between the concentrations of steroid hormones and the levels of specific antibodies in normal and pathology. For the first time there were revealed the direct correlations between the concentration of steroid hormones and the corresponding specific antibodies. In patients with breast cancer the relationship between estradiol and anti-estradiol antibodies were significant, but between progesterone and anti-progesterone antibodies were absent. Obviously the corresponding antiidiotypic antibodies to progesterone influenced on the interaction of progesterone with specific antibodies. So the previous assumption about the effect of antibodies to endogenous steroids generated in the natural conditions on their biological functions have obtained by the first confirmation.