The Results of Using the Pharmacological Preparation of Placenta Extract in In Vitro Fertilization in Women with Chronic Inflammatory Disease of Pelvic Organs in Anamnesis
The aim: to study the effect of immune correction with pharmacological preparation of placenta extract on maturation of oocytes, embryo quality and efficiency of in vitro fertilization (IVF) program in patient with sterility caused by chronic inflammatory diseases of pelvic organs. Material and Methods: the experimental group consisted of 31 patients with infertility caused by chronic pelvic diseases and unsuccessful IVF attempts in anamnesis. The control group consisted of 42 voluntary donors of oocytes. We used clinical, laboratory and instrumental methods. Standard long protocol with the use of analogues of gonadotropin-releasing hormone has been applied in induction of superovulation. The procedure in the experimental group differed from the standard one: patients were administered subcutaneously placenta extract at a dose of 1.8 ml — 5 injections every 2 days in the menstrual cycle prior to the initiation of treatment, according to the manufacturer’s recommendations. Morphological assessment of embryos was performed on a scale Erenus. Results: in patients of the experimental group therapy with pharmacological agent placenta extract in preparation for IVF, favorable effect on the characteristics of oocytes and embryos has been noted in assisted reproductive technologies, in particular fewer oocytes with signs of apoptosis, increasing the number of blastocysts, increased frequency of embryo implantation and, as result, an increase in pregnancy rate. Conclusions: the obtained results allow us to recommend a preliminary immunocorrection with pharmacological agent placenta extract as a preparatory treatment before IVF in women with infertility due to chronic inflammatory diseases of the pelvic organs.