The Analysis Of The Effectiveness Of Neoadjuvant Chemotherapy Of Breast Cancer
Objective of the study is the analysis of the effectiveness of neoadjuvant palliative chemotherapy of patients with breast cancer who had undergone treatment at Nizhny Novgorod Regional Oncologic Dispensary for the period from 2010 to 2015. Materials and Methods. Based on the study of surgical specimens grade of tumor pathomorphosis and its dependence on the basic parameters, which characterize breast neoplasm and affect the prognosis of the disease, were evaluated. Results. A statistically significant relationship between the grade of therapeutic pathomorphosis and the regimen of palliative chemotherapy performed was identified, it was revealed that consistent application of anthracycline - and taxane-based agents is the most efficient regimen as compared to the use of anthracycline-containing chemotherapy. The differences observed in the grades of therapeutic pathomorphosis, depending on age, stage of the disease, number of cycles of neoadjuvant palliative chemotherapy as well as on the immunophenotype of the tumor were not statistically significant. Conclusion. The study has shown that in general the results of neoadjuvant palliative chemotherapy, performed in Nizhny Novgorod Regional Oncologic Dispensary, comply with the outcomes reported in Russian and world literature. It is feasible to develop the methods of non-invasive monitoring in order to predict the effectiveness of the treatment of breast cancer.