The pathogenesis and prevention of complications of pregnancy conditioned by thrombotic microangiopathy
Thrombotic microangiopathy is one of the most severe thrombotic complications characterized by damage of microvessels of various organs and associated with thrombocytopenia and haemolytic anaemia. The term thrombotic microangiopathy embraces several nosologies characterized by various mechanisms of development of microthrombosis. At present, thrombotic microangiopathy refers to thrombocytopenic purpura (TP), haemolytic-uraemic syndrome, heparin-induced thrombocytopenia, HELLP syndrome. One of the significant triggers for development of thrombotic microangiopathy is pregnancy. This fact opens up wide perspectives to studying the pathogenesis of thrombotic microangiopathy in the context of physiological changes of haemostasis during pregnancy. On the other hand, discovery of the molecular mechanisms of thrombotic microangiopathy allows a new look at the pathogenesis of thrombotic complications associated with pregnancy, and also the pathogenesis of the so-called placental obstetric complications, including severe forms of preeclampsia.