GENETIC PREDICTORS OF EXPRESSION OF LONG NON-CODING RNAS, AS PROGNOSTIC FACTOR FOR COURSE AND DEVELOPMENT OF CERVICAL CANCER
Cervical cancer is one of the most common oncological diseases in female cancers. Studies of the last decade showed that long non-coding RNAs, known as key regulators of the majority of intracellular processes, could be considered as promising biomarkers for diagnosis and prognosis of tumor progression. Researching the mechanisms of participation of long non-coding RNAs in the initiation and development of cancer, can broaden the understanding of the biological basis of neoplastic cell transformation, and will bring great opportunities for using long non-coding RNA in molecular diagnostics. In this review, we summarized the origin and overview function of long non-coding RNAs, cited known examples of involvement of long non-coding RNAs GAS5, HOTAIR, MALAT1 and CCAT2 in cervical carcinogenesis. In addition, further detection of new long non-coding RNAs was taken into consideration as an opportunity to supplement knowledge about the cervical carcinogenesis and to come closer to understanding the molecular mechanisms of the occurrence, development and evolution of this disease.