Features of the expression of Hsp70, Hsp90 and GFAP in the rat hippocampus in the hypertensive encephalopathy model
The purpose of the work was to study morphometric features of rat hippocampal pyramidal layer and to assess the expression level of heat shock proteins Hsp70 and Hsp90 together with GFAP expression in hypertensive encephalopathy modeled in Wistar rats by 9G-force during centrifuge training (caudal-to-cranial direction) twice a day for 28 days. We revealed marked increase in the number of damaged neurons as well as decreased specific density of pyramidal layer neurons in all hippocampal zones. These signs of reversible and irreversible damage were accompanied by significant increase in the expression of Hsp70, especially pronounced in the CA3 zone. At the same time, significant enhancement of GFAP expression was most prominent in the CA2 and CA4 zones. The less marked increase in Hsp90 expression compared to Hsp70 suggests a lesser role for Hsp90 in cell survival in the modeling of hypertensive encephalopathy.