ON THE EFFECT OF OXYTOCIN ON THE STRUCTURAL AND FUNCTIONAL REORGANIZATION OF NEUROSECRETORY CELLS OF THE HYPOTHALAMUS UNDER CONDITIONS OF COMBINED STRESS
The purpose of research was to determine the effect of oxytocin on structural and functional changes in neurosecretory cells of the hypothalamus supraoptic nucleus of 30 rats subjected to emotional-painful stress, with the subse-quentintratrachealintroduction of E. coli suspension and rats received intramuscularly oxytocin after each session of stress and infections with bacteria. Supraoptic nuclei of the hypothalamus were studied by light, electron microscopy, immunohistochemistry. Studies have shown that the combined effects of stressor factors, there is a decrease in synthetic processes and intensification processes, leading to functional exhaustion and degeneration of the neurosecretory cells of supraoptic nuclei of the hypothalamus and their death by apoptosis. In animals treated with oxytocin at the ultrastructural level in the neurosecretory cellswas observed an increase and predominance of reparative processes over the destructive. In supraopticus nuclei, an increase in the number of cells in phases of the beginning of the synthesis, accumulation and excretion of the neurosecretion and decreasing the number of degenerating forms, with high level of functional activity of cells and reduce the number of cells positive for p53 protein and Tunel-reaction. The obtained results allow to conclude about the positive effect of oxytocin on the course of protectively-adaptive reactions in cells supraop-ticusneurosecretory nuclei of the hypothalamus and proper functioning at the exhausting action of the combined stress.