Comorbidity profile of the posmenopausal women with primary osteoarthritis
Aim. To assess comorbidity profile of the postmenopausal women with primary osteoarthritis. Methods. The study included 682 female postmenopausal outpaitients (age median медиана 56; 25% - 75%: 52.0 -: 60.0, postmenopause period: 6.8 yeaers; 25% - 75%:2.0 -: 11/55). Results. Every 4 of the 5 had Arterial hypertension, 72.3% had dyslipidemia and 51.6% had carbohydrate metabolism disorders, 7.3% women had a history of myocardial infarction or cerebrovacular events. Other comobdities included cholelythiasis (23.2%), peptic ulcer (11.6 %), hypothyroidism (16.4%), mild cognitive dysfunction (17.5%). Charlson comorbidity index median was 4 (3 -: 4). Charlson index increase positively associated with age (р < 0.001), postmenopausal period length (р < 0.001), severity of postmenopausal symptoms, osteoarthritis algofunctional index (р = 0.005). Comorbid patients had more severe pain (р = 0.001), more frequent anxiety (р = 0.035) and depression (р = 0,022). MMSE showed a moderate negative correlation with Charlson index (R=-0.41; P < 0.001), with age (R = -0,65; P < 0.001) and length of postmenopause (R = -0.48, P < 0.001). Conclusion. Every post5 menopausal outpatient with knee osteoarthritis needs comorbidity screening. Polimorbidity of the postmenopausal women is associated with a high frequency of emotional, affective and cognitive impairment.