X-ray therapy for trophic skin changes in endogenous hypercorticism
With endogenous hypercorticism syndrome of various origins (Itsenko-Cushing's disease, corticosteroma, ACTH-ectopic syndrome) trophic changes in the skin (ulcerative lesions, erosion, hemorrhage in the skin and subcutaneous fat, thinning of the skin) are often observed. The basis of these changes is, as a rule, vascular damage resulting from immunodeficiency. In a study by N. Chung et al. [3] it was shown that glucocorticosteroids negatively affect the interaction of endothelial cells with lymphocytes and worsen the penetration of the latter into the sites of active inflammation. Corticosteroids have a suppressive effect on the antigen-presenting function of lymphocytes, growth, differentiation and function of monocytes and lymphocytes, inhibit the production of cytokines, and block the activity of epidermal Langerhans cells.