Predicting the formation of organic anxiety disorder based on immunobiological parameters
Organic nonpsychotic mental disorders are one of the most significant problems of modern psychiatry. This is due to their high prevalence both in the population as a whole and in psychiatric and general somatic practice. Objective: to identify immunobiological predictors of the formation of organic anxiety disorder. Material and Methods. A comprehensive clinical-psychopathological, experimental-psychological and immunobiological examination of 42 patients with nonpsychotic mental disorders of the organic register is carried out. According to ICD-10, 25 patients (group 1) are diagnosed with organic emotionally labile disorder (F06.6), 17 patients (group 2) - organic anxiety disorder (F06.4). The levels of trait and state anxiety are assessed in all patients. The laboratory investigation includes phenotyping of immunocompetent cells on clusters of differentiation by flow cytometry and determination of hormone concentration by ELISA. The data obtained are processed statistically. Results. The method for predicting the formation of organic anxiety disorder is developed based on the immunobiological approach. By assessing the level of trait anxiety in patients with organic emotionally labile (asthenic) disorder, determining the immunological parameters in the blood, the concentration of TSH and thyroid hormones, and with values of the level of trait anxiety more than 52 points, the number of lymphocytes with receptors of readiness for apoptosis of more than 16%, the value of the immunoregulatory index less than 1.3 units. and the concentration of free triiodothyronine in the blood serum of less than 3.6 pmol/l predict the transformation of organic emotionally labile (asthenic) disorder, as the initial stage of nonpsychotic mental disorders of the organic register, into a protracted course with the formation of organic anxiety disorder. Conclusion. The developed method can be widely used in medicine and health care to predict the risk of the formation of organic anxiety disorder at an earlier stage of the disease, allows choosing an adequate strategy for psychopharmacotherapy, determining targets for psychotherapy.