Searching for genetic predictors of hypersensitivity reactions caused by using beta-lactam antibiotics
Beta-lactam antibioticsare still widely usedin clinical practice, as the drugs of choicefor the community-acquiredinfectionstreatmentand for treatment of upper respiratory tract, upper and lower respiratorytract infections.However, theirapplication in practiceis limited toa range ofadverse drugreactions, the most common of these inclinical practiceareallergic reactions.Allergy topenicillinsand cephalosporinsis most often seenin the formof cutaneousimmediate hypersensitivity, it is also possibleanaphylactic shock anddeath.At the present timethe worldis searching forgenetic predictorsto predictthis kindof adverse reactionsand todetect the presenceof allergy toantibioticsin the patient.This article gives an idea of the allergic reaction formation mechanism, as well as strategies to search for potential genetic predictors.