Pathobiochemical peculiarities of brain in critical states of organism and ground of metabotropic therapy. Part IIІ. Cerebroprotective effect of brain insulin and glycolytic intermediators
In this part of the article the many-sided role of cerebral insulin outside its connection with the mechanism of glucose transport and its importance for initiation of cerebroprotective effect were given. The importance of glycolytic intermediators of cerebral glycolysis in activation of neurocitoprotective processes is determined. Possibility of interorgan metabolic connection of liver and brain with regard to activating of cerebral glycogenesis due to strengthening of inhibition influence on the brain phosphorilase of fructose-1-phosphate, which is specific only to the liver, is considered. In conclusion approach of pathobiochemical ground of metabotropic therapy, directed to maintenance and stabilization of cerebroprotective processes in the critical state of organism is presented.