MECHANISMS OF THE PREVENTIVE EFFECT OF THE USE OF MEDIUM-MINERALIZED DRINKING MINERAL WATER OF IVANOVO REGION "RESHMA" IN THE ACUTE METABOLIC DISEASE IN THE EXPERIMENT
The purpose of the study is to give a qualified assessment of the chemical composition of water of the well 1/2000 (the territory of FSBPHF MC "Reshma" FMBA of Russia Kineshem district, Ivanovo region) and to study the preventive effects of the course application of the investigated water on an experimental model of acute metabolic disorder induced by subdiabetogenic dose of streptozotocin. Materials and methods. Mineral water of the well 1/2000 (the territory of FSBPHF MC "Reshma" FMBA of Russia Kineshem district, Ivanovo region). There have been used 45 of nonlinear white rats - males of 3 months old, comparable in weight (180-220 grams, when introduced into the experiment). Two blocks of studies were formed by a block randomization method: the 1st block was carried out on 20 of healthy animals where 10 rats (control 1) received a course of drinking water (PW) and 10 rats (test 1) got a course of MW "Reshma"; the 2nd block included 25 animals where 15 rats (control 2) got a course of drinking water and a model of acute metabolic disorder induced by subdiabetogenic dose of streptozotocin (ONmindSTC) and 10 rats (experience 2) had a preventive course of MW "Reshma" with subsequent reproduction of the experimental model (ONmindSTC). In the experimental groups there was a course drinking (21 days) of the investigated MW and DW (control groups) at a dose of 1.5 ml per 100 g of an animal weight per os using a probe. Results. There have been conducted the analysis of macroionic composition, microcomponents, total content of organic substances of the investigated water. It has been shown that in terms of the total content of organic substances characterized by permanganate oxidability (up to 0.64 mgO/l) is low and in terms of carbon of non-volatile organic compounds is less than (calculated analytically) the established balneological norm for assigning water to therapeutic table waters according to this indicator (5 mg/l < C or.sub. - < 15 mg/l). It was established that the preventive course use of Reshma mineral water on ONmindSTC model ensured the formation of metabolic reserves to protect cell membranes, which contributed to a decrease in the severity of insulin resistance. Conclusion. The data analysis of physicochemical properties of medium-mineralized sulfate sodium mineral water "Reshma and the study of the effectiveness of its use in experimental modeling of acute metabolic disorder induced by asubdiabetogenic dose of streptozotocin with animals (Wistar rats) determined the prospect of using it to prevent carbohydrate metabolism disorders.