Physiologically active compounds based on gamma piperidone
At present, all over the world, intensive research is being carried out in the search for and creation of new analgesic agents and their antagonists. This is primarily due to the fact that the opiate receptor agonists and antagonists used do not fully meet the modern requirements of practical medicine due to the presence of a number of undesirable side effects. The work is devoted to the synthesis of compounds of the piperidine series. Recently, in predicting biological activity, mathematical methods and computer technologies have found more and more active use to establish the relationship between the structure of a substance and the manifestation of the biological activity of new synthesized substances. The PASS program allows, based on the structure of a compound, to quantify the likelihood of the presence of various types of biological activity in it.