THE PECULIARITIES OF PREGNANCY COURSE IN WOMEN WITH THROMBOGENIC POLYMORPHISMS AND PLACENTAL PRESENTATION
To reveal the relationships between hereditary thrombophilia <file:///C:\Documents%20and%20Settings\Юля\Local%20Settings\Temp\Word_0>e and pathological placentation, 220 pregnant women with placenta presentation and 100 patients with physiological placentation were examined in the Altai region. The pregnant women were divided into two groups according to the placenta migration. The first (main) group included 70 pregnant women with complete chorion presentation during the first trimester and the absence of placenta migration by the period of delivery. The second (comparison) group was presented by 150 pregnant women with chorion presentation during the first trimester and its following migration during the second half of pregnancy. Obtained data proved the high frequency of genetic anomalies - 81,7% of cases in the patients of the main group, whereas in comparison and screening groups they were in 36,7 and 15,0 % of cases. The most important criterion of the difference between the main group and comparison group was the significant difference of the frequency of overlap of two or more intergenic allelic combinations. They were in 54,3 % of cases in the main group, 7,3 % in comparison group and they were absent in the screening group.