Urotropine: Sleeping History and Awakening
The paper is focused on the chemistry of a novel class of heterocage compounds - 1,4,6,10-tetraazaadamantane (iso-urotropine), which were recently synthesized by Russian scientists. The original approach to 1,4,6,10-tetraazaadamantane core structure assembly that was used for the synthesis of target iso-urotropine as well as some key transformations of this new heterocage compound are discussed. The plausible applications of iso-urotropine and its derivatives in biochemistry and medicine are also emphasized.