Study of gangliosides and their products hydrolytic decomposition - sphingosine - in the experimental parkinsonian sindrome
Study to determine the content of gangliosides and hydrolytic decomposition product of gangliosides - sphingosine with experimentally induced Parkinson’s syndrome. Experimental model of Parkinson’s syndrome is carried out daily by intraperitoneal injection of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrapiridin). As the results of the study, in the brain of animals with the syndrome of Parkinson’s disease, a decrease of all the main factions of gangliosides. Research has revealed the content of sphingosine increase of its content in the brain that appear to be explained by the hydrolytic decomposition of gangliosides. Our data suggest that dysregulation of the metabolism of gangliosides can will be a key mechanism in the pathogenesis of Parkinson’s disease.