Impact of Afobasol on the embryonal development of the posterity of rats exposed to tobacco smoke
White outbred rats were daily exposed to tobacco smoke ( 4 cigarettes containing 13mg of resin and 1 mg of nikotine in a volume of 72 dm3, for 20 min) per se or jointly with anxiolytic Afobasol from 1st to 20th day of pregnancy. Effects after tobacco exposure were a decreased growth of the pregnant females body weight, increase in post-implantation death, reduced craniocaudal size and fetus body weight, increased number of hematomas and hemorrhages in fetuses, decelerated ossification and dysplastic changes in cartilaginous tissue as well. The administration of Afobasol ( 1 to 10 mg/kg per os) led to reduced adverse effects of tobacco smoke on the embryonal development of rats.