Quantification of hexamethylenediamide <i>bis</i>-(<i>N-</i>monosuccinyl<i>-L-</i>seryl<i>-L-</i>lysine (GSB-106) in the blood plasma by HPLC-MS
The technique of quantitative determination of a new compound, possessing antidepressive activity, GSB-106 in the rat blood plasma was developed and validated. Analysis was performed by HPLC-MS. The method was linear in the range of 50-1000 ng/ml. Recovery of GML-1 was 82,15%. The low limit of quantification was determined as 50 ng/ml.