Nimesulide: a Variety of Therapeutic Perspectives
Nimesulide is one of the most widely used nonsteroidal anti-inflammatory drugs. A wide spectrum of effects and the optimal ratio of ,benefit/risk' are conditioned by the inhibition of cyclooxygenase 2, the influence on the adenosine concentration in the focus of inflammation as well as the other mechanisms. Analgesic and anti-inflammatory effect of Nimesulide in diseases of the musculoskeletal system is well studied. Information is being currently accumulated on its effectiveness in algodismenorrhea, anti-ischemic effect on neurons, the ability to inhibit the production of interleukin 6, induction of apoptosis of pancreatic cancer cells, as well as to have an anti-glycating effect. Therefore, it is not excluded, that the number of therapeutic points of Nimesulide application will be expanded.