Clinical and diagnostic significance of evaluation of enzyme activity of purine metabolism adenyl branch in rheumatoid arthritis
The activity of adenosine deaminase (ADA), adenine deaminase (AD) and AMP-deaminase (AMPDA) in lymphocyte and erythrocyte lysates of peripheral blood was studied in 77 patients with rheumatoid arthritis (RA) upon admission it hospital, after 10-12 days of treatment and on completion of inpatient care course. While the AMPDA and AD activity was increased in erythrocyte lysates in patients with RA upon admission to hospital, the ADA, AD activity was reduced in lymphocytes, with AMPDA activity increased. The enzymatic studies made it possible to diagnose the activity of the pathological process and the efficiency of a complex treatment of the patients with RA.