RISE OF REACTIVITY LEVEL OF ANTISTRTESS ADAPTATIONAL REACTIONS AS A MECHANISM OF THE SYSTEMIC ACTION OF THYMALIN UNDER PHYSIOLOGICAL CONDITIONS
The impact of thymalinon the characteristics of antistress adaptational reactions was studied in experiments on 33 white outbred apparently healthy presenile male rats. Dynamics of hematology indicators, changes in the weight of the thymus, adrenal glands, the ratio of these indicators as well as shifts of structure characteristics of the thymus of the animals allow to conclude that the remedy of thymus contributed to raising the level of reactivity in the development of general nonspecific adaptational reactions of calm and elevated activation. The results of the analysis of the micro picture of the thymus gland showed increasing of lymphoproliferative activity and enhancing of intercellular interactions involving tissue basophils in the central organ of the immune system under the influence of the thymalin. These results extend the current understanding of the systemic influence of the thymic peptide factors on organism and point to the prospect of activation therapy algorithms when these factors are used as a prophylactic and geroprotective remedies.