Functional Specifications of Microcirculation in Patients with Arterial Hypertension Associated with Metabolic Syndrome and Subclinical Hypothyroidism
Shown that the thyroid hormone deficiency adversely affects the cardiovascular system. However, the literature about the effect of subclinical hypothyroidism on the cardiovascular system are ambiguous. Objective. To study changes of the microcirculation in patients with arterial hypertension (AH) associated with metabolic syndrome (MS) and subclinical hypothyroidism (SH). Materials and methods. The study included 87 patients divided into 3 groups: 25 (28.7%) patients with AH, 37 (42.6%) patients with AH in the MS, 25 (28.7%) patients with AH associated with MS and SH. All the patients underwent examination of the state of microcirculation by laser doppler flowmetry. Results. In the group AH+MS+SH noted a significant increase in heart rate indices fluctuations (AmaxCF/3CKO), respiratory rate fluctuations (AmaxHF/3CKO) and intravas-cular resistance (AmaxCF/M) in the analysis of the distribution of these parameters within the groups as compared to healthy individuals, patients with AH and patients with AH associated with MS. In the group AH+MS+SH revealed a statistically significant decrease in the index of the effectiveness of the microcirculation (IEM) as compared in healthy and patients of the group AH+MS. Conclusion. Found that the presence of subclinical hypothyroidism causes redistribution mechanisms of regulation of microcirculation (the predominance of passive, active suppression mechanisms).