The role of IL-8 and LBP in the pathogenesis of bacterial overgrowth syndrome in patients with nonalcoholic steatohepatitis
The article presents data from a study whose purpose was to identify clinical and pathogenetic relationship between nonalcoholic fatty liver disease and bacterial overgrowth syndrome. The study found that bacterial overgrowth syndrome occurs in approximately 30% of patients with non-alcoholic steatohepatitis. With the development of bacterial overgrowth syndrome in patients with non-alcoholic steatohepatitis, NASH occurs during the most severe form, Bacterial overgrowth syndrome exacerbates the nonalcoholic steatohepatitis. It was also observed that the more pronounced during NASH fact revealed a significant increase in serum LBP and IL-8 in serum, and accordingly, the less pronounced for NASH, the detected values lower serum LBP and IL-8. Number of proinflammatory cytokines significantly increased in the serum with the progression of fibrosis, increasing the degree of histological activity in patients with NASH and ARIS. The positive correlation relationship between the levels of IL-8 and LBP and levels of transaminases. In the study of the level of histological activity and the determination of liver fibrosis also noted a positive correlation relationship between the levels of proinflammatory cytokines and the level of LBP in serum. To determine the tactics of these patients, all patients were divided into two groups. The first group (15 people) received basic therapy treatment of NASH: ursodeoxycholic acid 10-15 mg / kg body weight, lo-vastatin 10-20 mg 1 p / d during the evening meal, metformin 1500 mg / day, vitamin E 800 IU / day. In the second group (15 people) who received combination therapy treatment of NASH and ARIS: basic therapy for NASH added metronidazole 500 mg 2 p / day and a probiotic - enterozhermina 1 fl. 3r.d. Control treatment were above drugs for 12 weeks. Thus, by analyzing the data obtained it can be concluded that in patients with NASH and ARIS is most effective regimen DMARDs in combination with metronidazole and probiotic - enterozhermina. Against the background of this combination most effectively reduced transaminase levels of proinflammatory cytokines and damage LBP in serum.