INVESTIGATION OF EFFECTS OF STERID HORMONES ON CHROMOSOMAL TELOMERE LENGTH IN T-LYMPHOCYTE
Dexamethasotne, but not cortisone or estriol was found to be capable of diminishing telomerase RNA expression and promoting shortening chromosomal telomers in mitogen-activated T-lymphocytes. CD8+ T-cells were significantly more sensitive to acting dexamethasotne than CD4+ T-cells. Presumably, this may be related to the differences in both longevity and proliferative activity of the examined T-cell subpopulations.