Long-term effects of prenatal exposure to central M- and N-cholinblockers on the learning and memory of rats
It was found that embryonic exposure to Gangleron and Metamyzil as exogenous ligands H- and M-cholinergic receptors leads to long-term effects in the activities of central nervous system in adulthood offspring: broken such higher integrative brain function in rats, as learning and memory on the experimental model of the conditioned reflex of active avoidance (CRAA). The URAI test shown that prenatal administration of gangleron to pregnant female rats on 9-11 and 12-14 days of gestation violated the ability to purchase and playback active avoidance reflex in adult offspring. In the similar situation Metamizyl have a negative effect only for posterity the memory of offspring, disrupting the playback of CRAA. Thus, the long-term negative effect of cholinotropic compounds on learning and memory of adulthood offspring can be realized through both M- and N-cholinergic mechanisms of the developing brain.