Immunological features of the course of inflammatory diseases of large salivary glands
The purpose of this research was to study the immunological features of development of inflammatory diseases of large salivary glands. Forty patients with acute sialadenitis and chronic sialadenitis in the acute stage were examined. Patients underwent inpatient treatment in the department of maxillofacial surgery of the Vitebsk Regional Clinical Hospital. It was revealed that the level of IgG and IgM in the oral fluid of patients with inflammatory diseases of large salivary glands is significantly lower than in healthy individuals. In 62% of cases, there is observed a significant decrease of the level of sIgA in the oral fluid. The content of sIgA in the oral fluid of patients with inflammatory diseases of large salivary glands is significantly lower than in healthy individuals. On the base of the analysis of laboratory data, it can be concluded that in patients with inflammatory diseases of large salivary glands, there are deviations from the norm of the immunogram indices,associated with the violation of the functioning of its links. It was revealed that the level of interleukin-1 beta in the blood serum of patients with sialadenitis significantly increases with the development of inflammatory diseases of large salivary glands.