INFLUENCE OF THE PREPARATIONS OF GOUTWEED (AEGOPODIUM PODAGRARIA L.) ON LIPID METABOLISM IN RATS
It is ascertained that the preparations of goutweed (Aegopodium podagraria L.) aerial part at course intragastric administration (7 days) exert hypolipidemic effect in rats under the conditions of olive oil loading. The extract (1 g/kg) significantly reduced the level of triglycerides in blood plasma, the tincture (1 ml/kg) significantly decreased the level of plasma total lipids. The effects of the extract (1 g/ kg intragastrically) and the tincture (1 and 5 ml/kg intragastrically) were also studied in rats receiving hydrochlorothiazide (20 mg/kg intragastrically) against the background of excess fructose (10% drinking solution for 10 weeks). Excess of fructose led to an atherogenic shift in blood lipid fractions, that was partially eliminated by hydrochlorothiazide and its combinations with goutweed extract and tincture, while the combination with allopurinol (10 mg/kg intragastrically) did not result in normalization of the lipid metabolism parameters.