A meta-analysis of the research of the concentration of IL-17 in peripheral blood of patients with influenza A (H1N1) pdm09
Interleukin-17 (IL-17) is one of the inflammatory cytokines, which enhances including the effects of other pro-inflammatory cytokines. In order to increase the statistical power and increase the reliability of the results according to various researchers, including as a result of its own research, conducted a meta-analysis (a quantitative systematic review) study of IL-17 in peripheral blood of patients with influenza A (H1N1) pdm09. Question: to determine with a high level of confidence, whether IL-17, a marker of prognosis of influenza A (H1N1) pdm09. Searches were carried out research work on this subject in a variety of electronic databases (Medline, EMBASE, the Cochrane Controlled Trials Register, and others.), in dissertations, journals, thematic reviews, conference proceedings and other sources. 3 scientific papers were selected that met the criteria for inclusion / non-inclusion in the study (characteristic of scientific papers, diagnostic criteria, age of patients, comparable groups of patients, the presence of self-control, comparable research methodology, statistical criterion and the total number of independent studies). Selected studies have shown sufficient uniformity (homogeneity) comparison groups. This meta-analysis of scientific papers showed that the determination of serum IL-17, patients with severe influenza A (H1N1) pdm09 allows a high probability of predicting a favorable outcome. At the same time, the frequent unfavorable outcome of the disease (with a probability of 90% or more) indicates the absence in the serum of patients with influenza A (H1N1) pdm09 IL-17 (below the threshold of sensitivity of diagnostic test kits). Thus, the results of a meta-analysis of IL-17 level in the blood can be used in clinical medical practice for quite simple and convenient prognosis marker of influenza A (H1N1) pdm09.