MYELOID-DERIVED SUPPRESSOR CELLS AS A NEW THERAPEUTIC AIM IN ONCOLOGY
Myeloid-derived suppressor cells (MDSC) are considered as heterogeneous population of immature myeloid cells, mechanisms of action and clinical value of which are intensively studied over the last few years. The review deals with immunosupressive mechanisms of MDSC action as well as mechanisms, engaged in progression and metastasis of malignant tumours. The clinical findings focused on the analysis of prognostic value of MDSC in cancer patients have been summarized as well as different approaches aimed to decrease the ammount and/or functional activity of MDSC have been analyzed.