Diastolic and endothelial dysfunction at patients with hypertonic disease
Intracardiac hemodynamics of 45 patients with hypertonic disease of the 2nd stage were investigated by ECHO-CG.Endothelial function was studied by endothelin-1 and NO products in blood serum. There was expressed severe dys- function of intracardiac hemodynamics with prevalence of concentric myocardial remodeling with prevalence of hyper- trophic type. We have identified the expressed endothelial dysfunction. The presence of high direct correlations between the basic indicators of intracardiac hemodynamics and endothelial function confirms the pathogenetic value of distur- bances of endothelial function in cardiohemodynamic frustrations during the hypertonic disease of the 2nd stage. With- in 12 weeks of combined therapy with perindopril and bisoprolol at 73,3% of the patients purpose-oriented BP param- eters were aimed, and intracardiac and hemodynamics system was reliably improved.