Clinical and Hemodynamic Results of Applying Different Biological Prosthesis Models for Correction of Calcific Aortic Valve Disease
The aim of the investigation was to assess clinical and hemodynamic results of applying different biological prosthesis (BP) models for correction of calcific aortic valve disease in patients with high risk of developing thrombo-hemorrhagic complications resulting from long-term use of oral anticoagulants. Materials and Methods. Native aortic valve was replaced with different models of BP in 103 patients. Depending on BP type, all patients were divided into two groups. Group 1 included 65 persons (65% males, 35% females, mean age 66.4±5.5 years), who were implanted xenoaortic BP ASPIRE (Vascutek, Great Britain). In this group 85% of patients had heart failure Strazhenko-Vasilenko grade IIA, 94% of patients suffered from heart failure of functional class III according to NYHA. Group 2 comprised 38 persons (53% males and 47% females, mean age 66.0±3.0 years), who underwent failure correction by implanting frame-mounted xenopericardial BP “UniLine” (NeoCor, Russia). All patients in this group had heart failure Strazhenko-Vasilenko grade IIA and fell within functional class III according to NYHA. Results. In the early post-operative period two patients in group 1 died (total mortality amounted to 2%). At the time of discharge all patients fell within functional class I-II according to NYHA. There were no episodes of thrombosis, structural BP dysfunction, thromboembolic complications, early prosthetic endocarditis during the time of inpatient stay. Conclusion. Implantation of xenopericardial and xenoaortic BP models in aortic valve diseases of various genesis provides the possibility to correct impairment of intracardiac hemodynamics adequately and achieve good clinical and hemodynamic results. Choosing BP as a way of treatment is determined by low risk of thrombo-hemorrhagic complications and the opportunity to refuse from permanent intake of oral anticoagulants.