THE EFFECT OF DISORDER OF FORMATION OF THE INTESTINAL MICROBIOTA ON THE PROCESS OF HISTAMIN RELEASE AND DEVELOPMENT OF ALLERGIC DISEASES IN CHILDREN
The destination of the study is to determine the effect of disorder of formation of the intestinal microbiota on the process of histamin release and development of allergic diseases in children. Materials and methods. 110 children are surveyed: 70 - with hereditary predisposition to allergic disorders (the basic group) and 40 without a genetic predisposition (the comparison group). Additionally 30 mothers was conducted microbiological. The release of histamine was determined from 807 intestinal culture of the qualitative methodology. The results of the study - in children with atopic dermatitis registered is first a proliferation of opportunistic bacteria of intestine. It was established that the manifestation of atopic dermatitis in the early stages contribute: pathological of pregnancy, disorder of the microbiota of the mother. This is the ground of congenital reduction of colonization resistance and of disorder of formation of the intestinal microbiota. First detected high intensity production of histamine from aerobic gram-negative bacteria of intestinal on the preclinical stage of atopic dermatitis. The intense of histamin release correlated with severity of disorder of the intestinal microbiota and with severity and stage of the disease. The summary - disorder of formation of the intestinal microbiota cause of the intense release of histamin and а manifestations of atopic dermatitis in the first year of life.