Age dynamics of serotonin and 5-HIAA in serum of children with kanner syndrome
Serotonin is an important regulator of development and differentiation of central nervous system in embryogenesis and early postnatal development. In autism, age dynamics of blood serotonin differs from that in healthy children. The purpose of the study was to reveal the age dynamics of serotonin and its terminal metabolite, 5-HIAA in autism (Kanner syndrome). Age dynamics of serotonin and 5-HIAA was traced in 18 children with Kanner syndrome. Serum serotonin and 5-HIAA were determined by HPLC. Two-way ANOVA was conducted for statistical analysis. It was found that the level of serum serotonin was higher than the level of 5-HIAA. In autism, normal age dynamics of serotonin and 5-HIAA was disrupted: during the first years of life, serotonin and 5-HIAA were elevated and in adult age decreased as compared to the control values.