NIFEDIPIN-RETARD ALONE AND IN COMBINANION WITH BISOPROLOLI: COMPAPFTIVE EFICACY AND SAFETY IN PATIENTS WITH ARTERIAL HYPERTENSION
The purpose of investigation is to compare efficacy of nifedipin-retard (corinfar-retard, Jermany) used in monotherapy and combined with bisoprololi (concor, Nicomed, Austria) in patients with arterial hypertension (AH). The study 36 patients with AH by I and П stages, registered in the dispensary of policlinic № 7, Bishkek city. By 24-h AP monitoring, a four-week treatment with nifedipin-retard 40 mg day alone resulted in lowering of systolic arterial pressure. The combined treatment of nifedipin-retard in dose 20 mg/day with bisoprololi in dose 10 mg day full both in systolic and diastolic pressure. By sixe-week treatment diastolic left-ventricular function improved in combined therapy day produced a more pronounced fall in systolic diastolic pressure. Diastolic left-ventricular function improved in combined therapy.