The choice of prophylactic method for recurrent lower urinary tract infections in women
The efficacy of antimicrobial prophylaxis with furasidin potassium was assessed in 50 women (group 1) with a history of uncomplicated recurrent urinary tract infections for a period of 48 weeks (1 year). Furasidin (Furamag) potassium was administered in 50 mg 1 caps. daily (in the evening) for 3 months. In a group 2 (n=78) the efficacy of phytoprophylaxis with extract of rosemary leaves, lovage root and herb of centaury 2 tab.3/day for 3 months was studied. The control group without any treatment consisted of 40 women with a history of recurrent UTIs. Total follow-up period was 48 weeks. Relative risk in group 1 decreased to 0.29 (95% CI 0.19-0.43) compared with control group within 48 weeks. In a group 2 relative risk decreased to 0.88 (95% CI 0.78-0.99) compared with control group within 48 weeks. In a follow-up period 19 patients from group 1 had the recurrence of UTI, as well as 31 patients from group 2. They were included in group 3. Index of completeness of phagocytosis in group 3 was <1.1 in 43 (86%) patients. Abnormal level of CD4+/CD8+ lymphocytes was found in >2,0 in 23 (46%) patients and <1.2 in 9 (18%) patients. These changes are the evidence of the pathogenetic appointment of immunoprophylaxis validity. In group 3 lysates derived from 18 E. coli strains was administered in in 6 mg 1 caps. daily (in the morning) for 3 months. In the group 3 relative risk decreased to 0.15 (95% CI 0.07-0.29) compared with control group within 48 weeks.