TOXICOLOGICAL-HYGIENIC SUBSTANTIATION OF MAXIMUM PERMISSIBLE CONCENTRATION OF FLAX DUST IN THE AIR OF WORKING ZONE
Subchronic inhalation effect on white rats obtained from typical samples of industrial flax dust of mixed extract, fully containing soluble polysaccharide-protein antigenic substances, in decreasing concentrations caused the development in the organism dose-dependent severity, the same type of violations of the studied morphological and functional parameters mainly of general toxic, allergic and immunotoxic nature. Taking into account the criterion of the leading harmful allergic effect on the organism and on the basis of the established in the inhalation experiment inactive concentration of polysaccharide-protein complex of flax dust on the limiting indicator of the allergic effect, coinciding with the hygienic standard of the reference allergen - protein-containing grain-vegetable dust, the maximum permissible concentration of organic flax dust in the air of working area of enterprises for textile processing of flax fiber and the manufacture of products based on it at the level of 0.2 mg/m<sup>3</sup> for protein, 2 hazard class with the mark «Allergen»