RHEUMATOLOGY: MODERN ASPECTS OF PATHOGENESISAND PHARMACOTHERAPY OF JUVENILE IDIOPATHIC ARTHRITIS, STRATEGIC PATHWAYS
The review summarizes modern aspects of the pathogenesis of rheumatic diseases including JIA. The functional role of IL17, IL21, Th17-cells is demonstrated. The importance of intracellular signal transducers of cytokines Jak/STAT and Smad in the development of autoimmune disease is discussed. Promising directions of pharmacotherapy of rheumatoid diseases is described.