Analysis of effectiveness of antiviral therapy for chronic hepatitis C in patients of Poltava region
In the article, there is discussed the possibility of individual approach to the antiviral interferon therapy of chronic hepatitis C based on assessment of predictors of sustained virologic response in patients of Poltava region. The authors assessed the treatment effectiveness in 142 patients with chronic hepatitis C; 125 of them received double (PEG-IFN + RBV) antiviral therapy and 17 patients received a triple (PEG-IFN + RBV + SOF) antiviral therapy. The obtained predictors of low effectiveness of double interferon therapy of CHC (PEG-IFN + RBV) were the following: HCV genotype 1, age over 40 years, advanced fibrosis (F3-F4) by METAVIR, leukopenia, increased levels of GGTP and alkaline phosphatase, rapid progression of fibrosis, “mutant” genotype Asp299Gly of TLR4 gene. The double therapy is inappropriate in the identification of these predictors. Theeffectiveness of the triple therapy (PEG-IFN + RBV + SOF) in 17 patients with genotype 1 HCV was 100%. The significance of the effectiveness predictors of double therapy was leveled in sofosbuvir usage.