INTERRELATION OF APOPTOSIS AND ENDOGENIC INFLAMMATION IN MYOCARDIAL DYSFUNCTION PATHOGENESIS AGAINST ARTERIAL HYPERTENSION IN AGEING
For estimation of apoptosis and endogenic inflammation interrelation in myocardial dysfunction pathogenesis due to arterial hypertension were examined 184 elderly patients, middle age – 68,3 ± 1,8 years and 22 practically healthy persons of similar age by methods an echo – and dopplercardiography, assessment of serum caspase-3 level activity, concentration of C-reactive protein, factor of tumour’s necrosis and probrain natriuretic peptide. It is established, that stages of myocardial dysfunction progressing from isolated diastolic to systolodiastolic disorders connects with activation of endogenic inflammation, level TNF – α as initiator of the caspase cascade cardiomyocite’s apoptosis most significantly raised. We revealed staging peculiarities of apoptotic and inflammatory processes expressiveness in myocardial dysfunction pathogenesis due to arterial hypertension – prevalence of subclinical inflammation at early stage – diastolic dysfunction and apoptosis activation on late stage – systolodiastolic dysfunction. The markers of apoptotic and inflammatory activity may be used as predictors of myocardial dysfunction caused by cardiovascular diseases.