CHANGES OF BEHAVIOUR AND WHITE BLOOD PARAMETERS IN RATS IN THE DEVELOPMENT COURSE OF AUTOIMMUNE HYPOGONADISM
The article covers the dynamic study of grooming and locomotor activity, as well as the leukogramme of intact rats versus those with an autoimmune hypogonadism model. The animals were immunised by an allogenic testicular/ovarian homogenate injection. The grooming was registered using our own patented technique. The study showed that autoimmune hypogonadism development caused a significant decrease of elementary grooming acts count while the time spent on grooming was increasing. The late stages of the experiment demonstrated lowered grooming intensity as the evidence of discomfort behaviour. The locomotor activity in the immunised animals was also diminished. A progressive relativelymphocytosis against the background of hesitating levels of the other white cell types was prevailing in the follow-up leukogramme of the rats with autoimmune hypogonadism. Our work is the first one to estimate grooming as a development indicator оf such a systemic autoimmune pathology as autoimmune hypogonadism.