ТHE DISBALANCE OF CYTOKINES IN THE BLOOD AS A RISK FACTOR OF PREMATURE RUPTURE OF AMNIOTIC MEMBRANES
The analysis of the blood cytokine profile of 50 pregnant women with preterm rupture of amniotic membranes at 22–34 weeks´ gestation who were in hospital examination and treatment in the Department of Pathology of pregnancy of the Perinatal Center of Saratov region in 2012. Determination of the cytokine level in the blood (IL-4, IL-10, IL-2) of pregnant women conducted using the enzyme linked immunosorbent assay using the test system (production of JSC "Vector-Best", Novosibirsk, Russia) have been made. The clinical and laboratory examination revealed elevated level of IL-2, while reducing the content of IL-10, IL-4 in the blood of local population of pregnant women, which indicates the need for monitoring the content of these cytokines in the blood to predict complications during pregnancy.