P16ink4a protein expression in endometry hyperplasia associated with chronic endometritis
The aim of the study was to evaluate the expression of p16ink4a protein in the histological preparations of the uterine mucosa by the method of immunohistochemistry in women with benign endometrial diseases (chronic endometrium, endometrial hyperplasia). Materials and methods. 60 people were observed, which were divided into 3 groups: I group consisted of 20 women with histological examination of endometrium diagnosed with hyperplasia associated with chronic endometritis, group II (comparison group) - 20 patients with chronic endometritis, group III (group control) - 20 women with normal endometrium. In our material, in all women, endometrial hyperplasia is combined with a chronic low-activity endometritis. At the same time, 90% of these women register p16 ink4a protein expression more often as a diffuse form. In patients with chronic endometritis, p16 ink4a is detected in 85% of the observations, but only as a single expression. In women with normal uterine mucosa, in most cases (85%), expression of p16 ink4a is not observed. The foregoing indicates the need to examine patients who have endometrial hyperplasia in combination with chronic endometritis, for the presence of papillomavirus infection to optimize therapy.