ASSESSMENT OF THE EFFECT OF ANTI-IDIOTYPIC (SECONDARY) ANTIBODIES PRODUCED ENDOGENOUSLY AS A RESULT OF IMMUNIZATION WITH MONOCLONAL IDIOTYPIC (PRIMARY) ANTIBODIES TO TWO MORPINE DERIVATIVES ON THE BEHAVIOR AND THRESHOLD OF NOCICEPTIVE SENSITIVITY IN RATS
The paper presents materials on the study of the behavior of rats in the open field test and their nociceptive sensitivity after an immunization cycle with patented primary monoclonal antibodies to two morphine derivatives (6-hemisuccinyl and 3-carboxymethyl esters). It has been shown that endogenous production of antiidiotypic (secondary, Ab2) antibodies with morphine-like action and their long-term circulation in the body does not lead to the development of withdrawal symptoms after administration of naloxone hydrochloride, which are characteristic of opiate withdrawal, and does not change the threshold of nociceptive sensitivity in rats in the tail-flick test in response to thermal stimulation. The data obtained indicate the absence of an addictive potential in anti-idiotypic antibodies to morphine derivatives formed endogenously. The applied immunization scheme with idiotypic (primary, At1) antibodies as an antigen does not significantly affect the exploratory behavior of rats in the open field test and the pain threshold in the tail flick test in response to thermal stimulation.