GENETIC PREDICTORS OF DEVELOPMENT OF RESTENOSIS CORONARY ARTERIES (LITERATURE REVIEW)
The review presents an analysis of modern randomized studies, modern views on the issues of coronary artery restenosis; highlights the main issues of the optimal stenting technique, prevention of late stent thrombosis, and preventive measures using gene therapy. Purpose. Analysis of the literature of genetic predictors of coronary artery stenting and modern methods for its assessment; research on genotyping for CYP2C19 and PON1. Materials and Methods. To achieve the purpose of this review article, a systematic search and analysis of publication results and online resources was carried out for the period from 2000 to 2018. All publications were indexed in the data base PubMed, e-Library, Scholar. We found 250 publications on the topic of genetic polymorphism of genes during coronary stenting, of which 78 fit the main purpose of the research. Results. The analysis of the literature confirms the need for further research on the pathogenesis of restenosis after interventions, as well as on the search for methods of surgical correction and alternative tissue for the reconstruction of the coronary arteries. Conclusion. The relationship of the risk of cardiovascular diseases from genetic predictors was revealed. The selection of the most convenient and informative method for evaluating genetic predictors requires further research. Randomized multicenter studies are needed to assess the clinical and cost-effectiveness of a comprehensive genetic study.