THE INFLUENCE OF SYNTHETIC INDOLICIDIN ANALOGUES ON THE HE MATOLOGICAL INDICES IN THE RATS WITH EXPERIMENTAL PERIODONTITIS
Synthetic analogues of indolicidin are considered as potential antibiotics, since they have a wide spectrum of antimicrobial activity. We used synthetic analogues of indolicidin No. 7 and 8, which were used to correct experimental periodontitis in Wistar rats. Peptides were injected intraperitoneally at a dose of 500 pg/kg for 7 days after periodontitis modeling. The anti-inflammatory effect of indolicidin analogues was assessed by changes in integral hematological indices. A statistically significant effect of the studied indolicidin analogues on the neutrophil-to-monocyte ratio and the leukocyte index was established, which indicates to the effect of peptides on the macrophage-monocytic cell pool, as well as the affector and effector mechanisms of the humoral immune response.