Contemporary concepts on pathogenetic mechanisms of endothelial dysfunction in patients with calcinated aortic stenosis
We have examined pathogenesis and clinical aspects of endothelial dysfunction at patients with degenerative aortic stenosis. We have presented basic markers of anticoagulative, fibrinolytic, proliferative and antiinflammatory functions of endothelium, have been analysed their role in vascular and valvular modeling. We considered in detail the impact of various factors on the endothelial function of valves and blood vessels. The results of clinical studies that examined determinants of endothelial dysfunction to assess the clinical prognosis in patients with calcified aortic stenosis. It is found that one of the bases leading pathogenetic development of aortic stenosis is damaged endothelial layer, resulting in the overgrowth and redistribution of cells that is a physiological basis for the remodeling of the arterial wall and the structure of the apparatus of the aortic valve. Ongoing research at the present time, the endothelial markers may lead to a more simple samples for clinical evaluation of endothelial dysfunction. Research nature of endothelial dysfunction may predetermine considerable progress in understanding the pathogenesis of aortic stenosis.