EFFICIENCY COMPARISON OF PHARMACEUTICAL ANTIRECURRENT METHODS OF FIBROIDS TREATMENT AFTER CONSERVATIVE MYOMECTOMY
To evaluate efficiency of antirecurrent pharmacotherapy of fibroids in women of reproductive period after conservative myomectomy the comparative investigation were performed. Were examined 75 women, average age 32,4 ± 3,1 years, duration disease (fibroids) 4,29±1,5 years (from 2-to 7 years). Initial diameter of fibroids 45,82±20,76 mm, after conservative myomectomy 16,55±2,56 mm. Number of fibroids /per woman 5,18±2,5. Pharmacotherapy were provided with agonists of GnRH agonists, intrauterine levonorgestrel containing the depot - the system, antigestagens. GnRH agonists provide decrease of volume of uterus on 30% (from 325,4±16,2 to 227,8±10,1 sm <sup>3</sup>), number of fibroids nodes (from 5,45±2,53 to 2,54±1,36), diameter of dominant node (from 18,14±0,45 to 12,29±0,28 sm). Intrauterine levonorgestrel containing the depot - the system provide decrease of volume of uterus on 20% (from 312,4±15,0 to 252,5±8,8 sm <sup>3</sup>), number of fibroids nodes (from 4,87±2,7 to 2,27±1,9), diameter of dominant node (from15,57±0,4 to 11,57±0,22 sm). Antigestagens provide decrease of volume of uterus on 20% (from 315,0±9,0 to 250,6±10,0 sm <sup>3</sup>), number of fibroids nodes (from 5,2±2,53 to 0,86±0,99), diameter of dominant node (from16,22±0,55 to 12,87±0,5 sm). No significant deferens of efficiency depended from type of pharmacotherapy was found.