The role of the initial status of patients in course and prognosis of tick-borne encephalitis
On the clinical material obtained in the Novosibirsk region for a 10-year period, the authors demonstrated the variability of the morbidity ranging from 5.5 to 26.8 per 100,000 of the population and the specificity of the clinical picture of ТЕ in each epidemic season resulting from variations of natural human resistance and virus aggression factors that change quickly in time and through the populations. In selective examination of 145 blood serum samples by the method of PCR, the Far-Eastern genotype of the virus of tick-borne encephalitis was identified in 14 positive results (strain Sof'in) that corresponds to various clinical forms of disease: from unapparent, feverish forms to polyencephalomyelitic ones with lethal outcomes. For the past 5 years, among patients with tickborne encephalitis the percentage of people who received urgent immunoglobulin prophylaxis increased - from 6.2% in 2001 to 18.1% in 2003, and 26.4% in 2005. In the majority of patients with tick-borne encephalitis, the study revealed combined somatic pathologies of degenerative character that most often included initial damage of the central nervous system, which under the conditions of the established altered reactivity of the organism is regarded as one of the leading factors in the formation of the clinical variant and severity of disease. The integral multifactor clinical diagnosis that takes into consideration the interrelations of various pathologies during the patient's life, provides a physician with serious evidence for prognosis and differential planning of an effective regulatory therapy in the early period in case of outwardly similar symptoms of the acute phase of tick-borne encephalitis