CHRONIC SPONTANEOUS URTICARIA: HIGH DOSE AND PROLONGED INTAKE OF NON-SEDATIVE ANTIHISTAMINS OF THE SECOND GENERATION
Non-sedating antihistamine preparations of the second generation are reliable and effective first-line and second-line drugs for the treatment of patients with chronic urticaria of both spontaneous and induced forms. In most cases, the treatment is long-lasting with increased doses of antihistamines. In case of a long-lasting course with high antihistamine doses, a physician should prescribe the most effective and safe antihistamine preparations. The authors discuss effective doses, course duration, safety, effectiveness and algorithms for managing such patients.