FEATURES OF THE MICROBICIDAL SYSTEMS OF NEUTROPHILIC GRANULOCYTES IN THE TREATMENT OF EXPERIMENTAL BURN WOUNDS USING A 5 % GEL PECTIN COMPLEX WITH AMINOPHTALGIDRAZID
Evaluation of the state of microbicidal systems of neutrophilic granulocytes in peripheral blood and wound exudate on the experimental model of burn wounds in 20 rats in terms on the third, 5th, 7th and 10th day after the rejection of burn eschar. In the study group treated wounds were 5 % pectin gel with aminophtalgidrazid. It was noted that in the basic group of animals cationic protein content of peripheral blood granulocytes on the third day reached a level of 87 % of baseline and 71 % of control levels (P < 0,01). Cationic protein granulocyte wound exudate in the study group on the third day fell to 1,11 ± 0,12 conv. u (P < 0,01). Myeloperoxidase levels in peripheral blood granulocytes on the third day dropped by 18 % decreased (p < 0,05) with respect to its initial level and 31 % (P < 0,01) compared to control. Fluctuations in the level of myeloperoxidase granulocytes wound exudate were not statistically significant.