THE STUDY OF THE INFLUENCE OF EXOGENOUS SOURCES OF NITRIC OXIDE ON THE DYNAMICS OF INDICATORS OF MICROCIRCULATION BY OXIDATIVE STRESS IN THE EXPERIMENT
The aim of the study is to study the anatomical and physiological characteristics of the ways of blood microcirculation in the burn wound, in particular in the microvessel system of the parabiosis region against the background of the use of exogenous sources of nitric oxide on the example of the dinitrosyl iron complex. The experiment was conducted on 30 male Wistar rats weighing 200-250 g. The animals are divided into 3 equal groups. Group 1 - healthy intact animals, group 2 - control animals with combined thermal injury (WHO+TIT) and daily intraperitoneal administration of 1 ml. saline, group 3 main group with combined burn, the animals where in for 10 days were injected intraperitoneally with 10% solution dncg (1 ml of 0.3 mmol/l). For the assessment of the microcirculation we used the method of laser Doppler flowmetry in groups with injury at 3 and 10 days, the study area was the border zone of thermal injury. At the same time, it was noted that the microhemodynamics of the boundary region of the burn of the control group during the shock period was sharply increased and decreased below the intact level by the 10th day. Perhaps this is due to the inflammatory processes of the parabiosis zone. For the main group with the use of dncg characterized by a more stable state at a level slightly above intact. It is established that the rate of bypass surgery in the control group, the change of modes of blood flow from the Central to the collateral, and in the main group is dominated by the Central microcirculation. In General, the use of exogenous nitric oxide in thermal trauma allows to optimize microcirculation from the early stages and preserve the effect in further application.