Immune tolerance system and its state at organ transplantation(immunophysiological analysis)
In this article possible pathways to form immune tolerance on alloantigens in organ transplantation are discussed. It is emphasized that these pathways are monitored and controlled by preexisting mechanisms of central and peripheral tolerance with involvement of innate and adaptive immune systems but the role of mechanisms of regional peripheral tolerance is especially important. For induction of tolerogenic strategy in organism on alloantigens it is offered not only to perfect therapy schemes by decreasing doses of immunosuppressive drugs but also to work out medical reports for application of separate populations of tolerogenic cells and tissue factors.