Benzodiazepines in the treatment of premenstrual and menopausal syndromes
Objective. To provide an update-based assessment of the relationship between genetic disorders of the receptor system and somatic and autonomic dysfunctions developing in the framework of premenstrual syndrome and premenstrual dysphoric disorder. The results of new trials of the efficacy of tofisopam (grandaxin) were also analyzed. Material and methods. Publications available in the international science citation databases were sought and analyzed. Results. Tofisopam (grandaxin) is an anxiolytic drug but without muscle relaxant effects; and it can therefore be used in patients who continue to perform their professional duties. Tofisopam has the greatest autonomic stabilizing effect. Tofisopam has been shown to be particularly effective against autonomic disorders accompanying anxiety. Conclusion. Tofisopam remains one of the best drugs in the safety and efficacy ratio today.