Phenotypic and genetic features of the course of atrial fibrillation in the presence of arterial hypertension and abdominal obesity
In Russia and the whole world, atrial fibrillation (AF) and its progression are one of the main issues, as they cause a high risk of complications. Therefore, the definition of the role of genetic polymorphism in the development of this arrhythmia is extremely relevant in studying the genetic aspects of AF. An observational cohort study included a main group (MG) consisting of 57 men aged 45-65, diagnosed with AF, arterial hypertension (AH) and abdominal obesity (AO). The control group (CG) consisted of 59 men with AF, AH and without AO. The study evaluated clinical, anthropometric and laboratory parameters, results of instrumental diagnostics: ECG, 24-hour Holter ECG monitoring, EchoCG. The rs1378942 polymorphism of the CSK gene was tested by PCR with RFLP. In this study it was for the first time revealed that in men with AF and AH the rs 1378942, the SNP marker of the CSK gene, is associated with the body mass index (BMI) and the left ventricular myocardial mass index (LVMMI). The heterozygous genotype AC rs1378942 in the CSK gene is reliably more common in patients, regardless of the presence of AO. In group with AO, the AF progression occurred 2.57 times more often than in group without AO.