STRUCTURAL AND FUNCTIONAL TRANSFORMATIONS IN THE ADRENAL GLANDS OF THE RATS UNDER THE INFLUENCE OF GRAVITATION OVERLOADS AND PROTECTION FROM THEIR ACTION
The search for means of mitigating the pathological impact of systematic gravitation overloads on the integrative systems of the body, such as the endocrine organ of the adrenal gland, is an important actual task. The aim of the study was to study the structural and functional transformations in the adrenal glands of rats with the experimental regular effect of hypergravitation against the background of the counteraction of the liquid environment. Material and methods. A series of experiments were conducted in which 36 male Wistar rats who had reached the age of 2 months participated. The experimental group of animals was rotated every day for 10 minutes in a centrifuge (C-2/500) with the direction of the gravitational force 9g transverse to the axis of the body, combined with anti-overload protection of the liquid. Control rats were not subjected to gravitational overloads. On the 10th, 30th and 45th days from the beginning of rotation sessions, rats were decapitated under ether conditions with ether vapor. Before fixing the extracted adrenal glands, they were weighed. Structural features of the organ were assessed by light microscopy in sections stained with hematoxylin and eosin and by Van-Gieson. The ultrastructural characteristics of adrenal cells were studied with the help of the electron microscope PEM-125K Sumy PO "Electron". Results. In general, the organ is observed dystrophic changes in the ratio of structural elements and ultrastructural components of cells. Most significant, these changes are present in the first 10 days of hypergravitation effects. Further negative structural and functional transformations decrease. Conclusion. Estimating the results of experiments with mechanical water protection against the systematic influence of hypergravitation, it was found that the application of the proposed anti-overload device does not in any way guarantee a significant positive result in maintaining the normal structure and function of the adrenal glands in rats.