FEATURES OF POLYMORPHISM OF GENE CCR5 CHEMOKINE RECEPTOR AND MORPHOLOGICAL CONSTITUTION IN PATIENTS WITH ASTHMA AND THEIR FAMILIES
It was studied the distribution of genotypes and alleles of the gene CCR5 chemokine receptor and constitutionally-morphological phenotypes in the group of patients with asthma, their relatives, and in the group of healthy controls. The study was conducted on the material of 62 Russian families of patients with bronchial asthma (total 232 people) citizens of city Krasnoyarsk. It was found that the polymorphism gene CCR5 chemokine receptor in the coding area is associated with allergic asthma and is an important component of genetic predisposition to asthma. In patients with bronchial asthma, the greatest number of correlation refers to the fat component of body weight. Taking into account that we have found the association of asthma with genotype II gene CCR5, there is a reason to believe that fat dimorphism is a factor contributing to polymorphism of the gene responsible for the development of allergic asthma.