METHOTREXATE EFFECT ON DIFFERENT SPROUTS OF BONE MARROW HEMATOPOIESIS
In mice (СВА х С <sub>57</sub>В1 <sub>6</sub>)F <sub>1</sub> exposed to methotrexate (MT, 10 mg/kg) at 4, 7, 10 and 14 days after cytostatics administration as well as in intact animals of the same line a comparative assessment of the myeloid, erythroid germs and lymphoid hematopoiesis by determining in bone marrow of the total pool myelokaryocytes, normoblasts and lymphocyte, and peripheral blood the absolute content of leukocytes, segmented neutrophils, reticulocytes, red blood cells and lymphocytes was conducted, maximum depression under the influence of cytostatics (4 day) erythroid germ blood was defined, that at the same time was characterized by the most rapid normalization (10 days). Myelo-and lymphopoiesis inhibition was less pronounced, but was marked by longer duration (14 days). A possible assosiation of the identified changes with the features of the kinetics of the studied hematopoiesis germs, including the proportion of proliferating cells and the duration of the mitotic cycle.