IMPACT OF INNATE IMMUNITY GENES IN DEVELOPMENT OF CRITICAL POSTOPERATIVE COMPLICATIONS AFTER CORONARY ARTERY BYPASSES GRAFTING
Introduction. Postoperative critical complications after coronary artery bypass grafting are the result of innate immunity functioning that related with individual features and sometimes genetically determined. The aim: to evaluate the contribution of innate immunity genes polymorphisms in the development of critical postoperative complications of coronary artery bypass grafting. Design and methods: 680 patients with coronary artery disease after coronary artery bypass grafting were involved in the investigation. TREM-1 and TLR genes polymorph loci were genotyped using allele-specific real-time PCR. Results. It was found that allele G rs1817537 (OR = 2,94 (95%CI = 1,09-7,92); р = 0,019), allele Т rs2234246 (OR = 3,64 (95%CI = 1,24-10,73); р = 0,0076) and allele Т rs3804277 (OR = 2,94 (95%CI = 1,09-7,92); р = 0,019) of TREM-1 gene are associated with high risk of multiple organ failure while allele C rs3775073 TLR6 (OR = 0,33 (95%CI = 0,15-0,71); р = 0,0045), allele А rs7768162 TREM-1 (OR = 0,46 (95%CI = 0,21-0,98); р = 0,043) and T/T genotype of rs4711668 TREM-1 (OR = 0,22 (95%CI = 0,05-0,97); р = 0,015) are associated with decreased risk. Conclusion. Rare alleles in some polymorphic sites of innate immunity genes demonstrate the importance in multiple organ failure development.