ANALYSIS OF PLATELET AGGREGATION IN DONORS OF BLOOD COMPONENTS
The functional state of platelets can be determined using the method of platelet aggregation. The aim of our study was to investigate platelet aggregation in donors of blood components and to identify the features of the reactions of these platelets with the most common inducers of aggregation. Material and methods. 31 donors of fresh frozen plasma and platelet concentrate were included in the study. The study of platelet aggregation was carried out by the turbidimetric method with AP2110 analyzer (SOLAR, Minsk, Republic of Belarus). Results. A total of 33 studies of platelet aggregation in donors were carried out before the collection of blood components. Normal platelet aggregation was found in 10 cases (30.3%), hypoaggregation in 15 cases (45.5%), and hyperaggregation in 8 studies. (24.2%). Thus, in 23 (69.7%) cases, platelet aggregation disorders were found in donors. Statistical analysis showed that the incidence of platelet aggregation disorders (hypo- or hyperaggregation) was high in donors who had undergone COVID-19 infection (5 - hypoaggregation, 4 - hyperaggregation). In donors with no history of this infection, the incidence of platelet aggregation disorders was statistically significantly lower - 63.6% (in 10 - hypoaggregation, in 4 - hyperaggregation), p=0.04. A history of previous COVID-19 infection in the donor is an independent predictor of platelet aggregation disorder (Chi-square=7.24, p=0.007). Conclusion. When preparing platelet mass, it is necessary to first monitor platelet aggregation, especially in donors with a previous COVID-19 infection, and take into account the results obtained to predict the therapeutic effect of using platelet concentrate in clinical practice.