PHARMACOKINETIC MODELING AND CALCULATION OF ABSORBED DOSES IN RADIOIODINE THERAPY OF THYROID CANCER
A two-compartment model of the kinetics of a thyroid-stimulating radiopharmaceutical was developed taking into account the radiation damage of thyroid tissue residual after thyroidectomy as a result of internal irradiation during radioiodine therapy. Kinetic curves of changes in radiopharmaceutical activity (time-activity curves) in the model compartments for four patients with thyroid cancer were obtained. On the basis of this model calculations of individual threshold and total absorbed doses in thyroid tissue are carried out.