Expression of markers MMP-9 and TIMP-1 in the tumor tissueof the colon
The article presents the results of an immunohistochemical study of the expression of the markers matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinases-1 in patients with colon adenocarcinoma. The structural components in which expression of MMP-9 is possible are revealed: tumor cells, large epithelioid-like cells, inflammatory cells, fibroblasts. The findings suggest that the protease and its tissue inhibitor are unevenly distributed between tumor and stromal colon cancer cells. There is an increase in the frequency of a positive reaction in the epithelial cells of the tumor in a state of epithelial-mesenchymal transition in patients with metastases.