Cytokine production in blood cells and the level of serum C-rp in patients with cardiovascular diseases
The aim of the investigation was to study the peculiarities of cytokine production in blood cells in correlation with the serum C RP level in patients with different cardiovascular diseases. 11 patients with arterial hypertension (1st group), 10 patients with stable angina II IIIFC (2nd group), 55 healthy volunteers (3rd group) together with 5 patients with atrial fibrillation (AF), middle aged 52,1 ±10,00 years, were under observation. Their blood was taken for the determining of serum level of C RP and both, spontaneous and mytogene stimulated cytokine production in blood cells. They were evaluated by the immunoenzyme method. There were no significant differences between the patients of the 1st and the 3rd groups in all parameters, except C RP. Patients with the stable angina had lower stimulated production of IL 1 β in comparison with those from the 1 st group, but significantly higher C RP level in comparison with the 3rd group. Small number of AF cases demonstrated the highest spontaneous production of IL 1 β and TNF α. Correlations between cytokine production and heart anatomy were found. No correlations between cytokine production and C RP level were described. These results demand further investigation. Key words: cardiovascular diseases, cytokines, blood cells, C RP