Possibilities of using Normospectrum for prevention of nosocomial purulent-septic complications in patients with rectal cancer
The authors carried out a clinical trial of the synbyotic preparation Normospectrum with the purpose to introduce it into the practice of pre-operative preparation and post-operative management of patients with rectal cancer. The study involved 150 patients of an oncological clinic divided into three groups of 50 patients each, homogeneous by the character and severity of disease, and also by age and gender. In the course of the study a reliable decrease of the incidence of nosocomial purulent-septic infections during the post-operative period was obtained as compared to the control group that received standard therapy during the pre-operative and post-operative periods. In the group where selective decontamination of the intestines in combination with antibiotic prophylaxis of wound infections and administration of the sorbent Irmalac were added to the standard preparation, the percentage of complications was reduced twofold. With the inclusion of Normospectrum in this scheme the incidence of postoperative complications became lower than in the control group by 4.5 times.