PATHOPHYSIOLOGY AND EXPERIMENTAL THERAPY OF LIPID METABOLISM DISORDERS
The article presents the pathophysiological assessment of dyslipidemia simulation results found in rats. In the experiment found that dyslipidemias induced by adrenaline hydrochloride, hydrocortisone acetate and prescribed аtherogenic diets are accompanied by the increase of total cholesterol (TC) in blood, triglycerides (TG), low density lipoproteins (LDL) cholesterol, and by the decrease of high density lipoproteins (HDL) cholesterol. They are also followed by the increasing concentration of malondialdehyde’s (MDA), diene conjugates (DC), modified low density lipoproteins in blood, and by the decreasing activity of catalase. The evaluation of the pharmacotherapeutic efficiency of multicomponent phytogathering for induced dyslipidemias was conducted. The course preventive administration of the phytoremedy results in decrease of the ТС, TG, LDL cholesterol content and increase of HDL cholesterol. Besides, the remedy inhibits the formation of products of lipid peroxidation anincreases the antioxidant potential.