ARTERIAL FUNCTIONAL STATEMENT AND VESSEL WALL MORPHOLOGY IN INFLUENZA INFECTION
It is well known that influenza virus is able to reproduce in endothelial cells and cause an endothelial dysfunction. Mice were infected by A/H1N1 (A/California/07/09/pdm09) influenza virus intranasal administration in LD<sub>25</sub> and LD<sub>50</sub> doses. Functional and morphological statement of the vessels were assessed after 3, 5 and 7 days after infection. Intrapulmonary arteries and 1<sup>st</sup> order mesenteric arteries showed different shifts in vasomotor reactions. However, vessels’ mechanical properties impairment and morphology were changed in a similar way. All changes were dose- and time dependent.