DEVELOPMENT AND VALIDATION OF LC-MS/MS METHOD FOR DESLORATADINE DETERMINATION IN RABBIT PLASMA
A new method for drug desloratadine determination in rabbit plasma using HPLC-MS/MS has been described. The sample preparation has been made by protein precipitation with methanol. The method has been validated in terms of selectivity, calibration curve, accuracy, precision, lower limit of quantification, carry-over and stability. The analytical range was 0.5-10 ng/mL. Method could be used for preclinical PK-studies of desloratadine.