Overview of pathogenetic mechanisms of hirudotherapy and the its rationale for the treatment of patients with cerebrovascular disease
Summary. The aim of the study - summarized and presented data on the pathogenetic mechanisms of hirudotherapy and its effectiveness in different groups of patients. Results. The secret of the salivary glands of the medicinal leech inhibits abnormal platelet aggregation and adhesion, inhibits the inner path of the plasma hemostasis, destroys fibrin, has a protective antithrombotic effect and provides a blood clot lysis witch had already formed, lowers elevated levels of total cholesterol, triglycerides and low density lipoproteins of blood plasma, has a protective effect in endothelial cover. Hirudotherapy, improves microcirculation and reduces ischemia of tissues and organs, has a hypotensive and neurotrophic effects. Give a review of the effective application of hirudotherapy in different groups of patients with cerebrovascular disease: chronic cerebrovascular insufficiency, in the acute phase of ischemic stroke, in patients with the consequences of ischemic stroke. Conclusions. So, now there is a sufficient theoretical pathogenetic and practical basis of effective use of hirudotherapy in patients with various forms of cerebrovascular diseases.