IMMUNITY AND LYMPHOCYTE-PLATELET ADHESION IN DIFFUSE TOXIC GOITER
In patients with diffuse toxic goiter (DTG), relative numbers of CD4+, CD8+ lymphocytes, activated T-lymphocytes (CD3+HLA-DR+) proved to be increased, whereas absolute contents of T-independent (CD3-CD16+CD56+), and T-dependent (CD3+CD16+CD56+) NK-cells were found to be decreased. Moreover, IgA and IgM levels were decreased among DTG patients. In most DTG cases, amounts of lymphocyte-to-platelet agregates were sharply decreased. Studying parameters of immunogram, lymphocyte-platelet adhesion allows of assessing specific changes of adaptive immune response in diffuse toxic goiter.