THE CHARACTERISTICS OF CORRELATIONS BETWEEN HIGHER FATTY ACIDS METABOLISM, THE LEVEL OF TNF-Α AND STNF-RI IN THE CERVICAL CELLS DURING CERVICAL CANCEROGENESIS
The biochemical atypism is one of the feature of tumor cells. It is known that there is an excess of saturated fatty acids with increasing the proportion of the odd chain fatty acids in the cervical cancer cells. Against this background, a high level of tumor necrosis factor-α (TNF-α) and its soluble receptor (sTNF-RI) is recorded. The aim of the study was to establish the characteristics of correlation between higher fatty acids, the level of TNF-α and sTNF-RI in the cervical cells during cervical cancerogenesis. Methods of research was the spearman rank correlation method. The variety of correlations relationships between the investigated parameters were established. The most pathogenetically significant of them were positive correlations with the level of saturated fatty acids, negative bonds with the values of monounsaturated fatty acids, and various correlations with polyunsaturated fatty acids. The revealed correlations between the studied parameters indicated to the important pathogenetic role of higher fatty acids, tumor necrosis factor and its soluble receptor in the cervical carcinogenesis.