PROGNOSIS IN PATIENTS WITH IDIOPATHIC MEMBRANOUS GLOMERULONEPHRITIS
Idiopathic membranous glomerulonephritis in adults is poorly understood disease. There are controversial data concerning with prognostic criteria, treatment regimens effectiveness etc. The aim of our study was clinical and laboratorial evaluation of idiopathic membranous glomerulonephritis patients with different immunosuppressive treatment regimens and detection of disease prognostic criteria. Materials and methods. The natural history in the retrospective and prospective analysis were studied in 119 patients with idiopathic membranous glomerulonephritis. All patients diagnosis idiopathic membranous glomerulonephritis based to morphological examination of the kidneys in accordance with generally accepted criteria. Results. Nephrotic syndrome was detected in 76.1% cases. Levels of hematuria, cylinderuria and lipoiduria varied. Hypertension was detected in 57.3% patients, concentration function disorders - in 23.9%, and nitrogen-excretion disorders - in 43.8% cases. Conclusion. Prognosis-negative factors were: proteinuria more than 3 g/d, persistent arterial hypertension, renal insufficiency at presentation, moderate to severe extracapillary proliferation, tubule-interstitial and fibroplastic changes, age of more than 40 years and male sex.