Pregnancy Miscarriage And Gene Polymorphism Of Blood Clotting System
Genotypes distributions for the 3 genes of blood coagulation factors (FV Leiden, PROT G20210A, FGB G-455A) and MTHFR C677T were compared in 172 women with miscarriage and a control population (108 women without a history of pregnancy loss). No significant differences were observed between distribution of any studied gene variants in the miscarriage and control groups. When the whole patients group was divided into subgroups, the frequency of MTHFR T/ T genotype in women with 3 and more spontaneous abortion was significantly increased. Patients with antiphospholipid antibodies had any form of "genetic thrombophilia" in 34,7 %, and women in control group only in 20,4 % (p < 0.05). Presence of inherited thrombophilia factors in 70 % of cases correlates with presence of AFA. Questions of expediency predictive genetic testing of genetic factors of hypercoagulation for preventive maintenance of miscarriage are discussed.