LIPID PEROXIDATION AND ANTIOXIDANT PROTECTION SYSTEM IN RATS OF VARIOUS AGES IN EARLY AND LATE PERIODS OF POLYTRAUMA
Objective - to study the state of lipid peroxidation and the enzymes activity of antioxidant protection system in early and late terms in rats of various ages. Material and methods. The experimental research was performed in 60 unbred white male rats of various ages (3, 6 and 24 months); all of them were exposed to polytrauma. The level of malon dialdehyde (MDA), superoxide-mutase (SOM) and catalase was examined in 1, 3, 24 hours and in 14 days after the trauma. Results. In early terms the content of MDA increased in animals of all ages and gained its maximal meaning in 24 hours in rats aged 3 months. The activity of superoxidemutase increased in 3 hours after polytrauma and was followed by marked decrease in 24 hours especially in the group of young animals. The activity of catalase in blood serum increased within all examined terms with maximal meaning in 24 hours and was followed by the tendency to its normalization on the 14th day. The enzyme reserves in the liver were exhausted; and its activity diminishment in 1, 3 and 24 hours which was followed by the activity growth on the 14th day testified to this fact.Conclusions. The revealed dynamics of lipid peroxidation and the reaction of the antioxidant protection system in different periods of traumatic disease in animals of various ages testified to the presence of age distinctions mainly in the system of antioxidant protection; these distinctions were contained in its great activity in reproduc- tive period and its insufficiency in the stage of involutional alterations.