Controlled supervised by the patient in the early postoperative period at gynecologic patients
Objectives. To carry out the efficiency estimation of patient-controlled analgesia (PCA) in the early postoperative period in patients after gynecological surgery. Methods. Depending on the performed treatment the patients were divided into three groups. To relieve postoperative pain the method of patient-controlled analgesia with the infusion of morphine bolus doses was applied in all groups. While using the PCA method in 32 patients TsOG-1 inhibitor ketorol (group A) was additionally applied; in 36 patients - TsOG-2 inhibitor parecoxib (group B) was used. The other 29 patients (control group) did not receive the preparations of nonsteroid anti-inflammatory agents. The visual analogue scale (VAS) of pain has been widely used and studied as a method of postoperative pain measurement in each of the allocated groups. Results. The conducted research permits to state that the additional use of ketorol and parecoxib combined with PCA procedure with morphine provided an authentic decrease of the used morphine within the first 6 hours of PCA and in general for all circadian period of this technique application. At the same time difference of the used morphine quantity within singled out time intervals wasnt statistically significant (р>0,05) between groups A and B. It means that ability of ketorol and parecoxib to reduce morphine requirements in patients during PCA procedure turns out to be almost identical. Conclusions. Identical efficacy of ketorol and parecoxib in providing of total daily morphine dosage reduction during patient-controlled application has been confirmed.