BORCHLORIN LIPOSOMAL DOSAGE FORM
Chlorin derivatives have great interest as photosensitizers for photodynamic therapy of malignant neoplasms during the last decade. The main goal of this research was to develop sterically stabilized liposomal dosage form for intravenous intake of new home-produced photosensitizers Borchlorin. Optimum composition and formulation of liposomal dosage form of hydrophobic Borchlorin are results of the Study. Concentration of Borchlorin in freshly prepared liposomes is upwards 99% and vesicles average size is - 185±10 nm. Developed dosage form shows low dark phototoxity and high cytotoxicity against rat glioma cells C6.