EXPERIMENTAL EVALUATION OF THE EFFECT OF PHYSICAL LOAD ON LUNG DAMAGE DURING INTOXICATION WITH PULMONOTOXIC SUBSTAGE
Intoxication with pulmonotoxicants can occur in case of emergencies at chemically hazardous objects, exposure to a chemical damaging factor in fire. Pulmonotoxicants with an acylating effect (carbonic acid dichloroanhydride, perfluoroisobutylene), when they enter the body, disrupt the functions of the respiratory system up to the formation of toxic pulmonary edema. The duration of the latent period and the severity of lung damage after poisoning with pulmonotoxicants depends on many factors, in particular, on the level of physical activity and the characteristics of evacuation in the early post-intoxication period. The experimental study was conducted on rats, the animals were divided into groups: “control”, “intoxication”, and “experience”. Animals of the groups “intoxication” and “experience” were subjected to static inhalation intoxication with carbonic acid dichloroanhydride at concentration of LC<sub>50</sub>. The animals of the “experience” group were subjected to physical activity at the “Trad-mil” installation 1 hour after exposure. After 3 hours after exposure, the pulmonary coefficient was determined, histological preparations were prepared and microscopic examination was performed. It was founded that exposure to carbonic acid dichloroanhydride (LC<sub>50</sub>) on rats did not lead to an increase (p<0,05) in the pulmonary coefficient and the appearance of histological changes in lung tissues. The presentations of physical stress to the animal of the “experience” group led to an increase (p>0,05) in the pulmonary coefficient and the appearance of histological sings of toxic pulmonary edema 3 hours after exposure. The obtained results of the experimental study can be used for planning and organizing medical care for victims who have undergone acute inhalation with pulmonotoxicants.