Effect of agonist of μ-opiate receptors DAGO on peripheral vascular tone during acute stress
The role of highly selective agonist of μ-opiate DAGO receptors in modulation of stress vasoconstriction estimated according to reovasographic method has been studied on Wistar rats in the conditions of acute stress. Selective activation of μ-opiate DAGO receptors in the conditions of acute stress resulted in the decrease on stressful growth of peripheral vascular tension. It was determinated the role of vasoactive endothelial factors - nitrogen oxide and endothelin-1 on the protective effect DAGO on a stressful growth of peripheral vascular tension.