Prenatal stress and kidney pathology in children
The article presents scientific information on the role of stress in the development of kidney disease according to modern literature and our own data. The importance of stress in the pathology of childhood is due to the fact that stress has three interrelated directions: stress as a negatively influencing link in the adaptation mechanism, stress as a link in the pathogenesis of diseases that worsens their course and adaptation to stressful situations as a natural prevention of stress diseases. The most common manifestations of stress are fetal hypoxia, metabolic disorders, and toxic effects leading to uncontrolled oxidative stress at the cellular and tissue levels. Stress leads to the development of pregnancy complications, intrauterine growth retardation syndrome (IUGR), persistent changes and pathological conditions of organs and systems. Prolonged antenatal and postnatal hypoxia lead to the formation of diseases of various organs and systems, including kidney diseases at an early age.