Cytokine gene polymorphism and Ureaplasma urogenital colonization in women of reproductive age
In order to find out correlation between Ureaplasma urogenital colonization in women and their genetic specificity of immune system 85 women of reproductive age which vaginal biocenosis was described as normal were included into the study. Cytokine gene polymorphisms were detected by real-time PCR, test-systems and equipment NPO DNA-Technology. Pro-inflammatory genotype correlated with absolute normocenosis, while anti-inflammatory" genotype - with persistence of Ureaplasma spp. in quantity > 104 GE/ml. The absence of subjective signs of vaginal pathology in women with Ureaplasma persistence correlated with host pro-inflammatory genotype.