COMPARATIVE ANALYSIS OF CARDIOPROTECTIVE EFFECT OF VARIOUS ANTIOXIDANTS AT SURGICAL ENDOINTOXICATION
The paper presents the results of an experimental study of the influence aplegina, vitamin E and emoxipine on changes in the qualitative and quantitative composition of lipid tissue structures of the heart, the intensity of lipid peroxidation, antioxidant capacity, phospholipase A2 activity, morphology and function of the heart muscle. Shown in a comparative perspective the cardioprotective effect lipidreguliruyuschy drugs, which is implemented not only by reducing the intensity of lipid peroxidation and increase enzyme antioxidant potential myocardial tissue structures, but also due to depressed activity of phospholipase A2. Efficacy in restoring the functional changes in the heart correlated with their ability to correct qualitative and quantitative changes in lipid profile. For background use drugs reported decrease in the free fatty acids, lysophospholipids, elevated levels of total phospholipids, phosphatidylcholine.