Concomitant pathology in patients with liver steatosis of different etiologies living in rural medical areas
Background. Combined pathology is an independent risk factor for death in the patient. Fatty liver disease (FLD) of both alcoholic and non-alcoholic etiology occupies a leading place in the structure of diseases of internal organs in Russia, which necessitates a comprehensive approach to the treatment of this pathology. Aim. To study concomitant diseases in patients with liver steatosis of both alcoholic and non-alcoholic etiology at a rural therapeutic site. Methods. The study involved 1,152 rural residents. Results. Liver steatosis in the framework of alcoholic liver disease (ALD) was detected in 167 (14.5%) people, average age 50.3+11.1 years, of which 96 (57.5%) men and 71 (42.5%) women (p>0.05). There were 145 smokers (86.8%). Liver steatosis in the framework of non-alcoholic fatty liver disease (NAFLD) was observed in 225 (19.5%), the average age of 59.7+11.0 years, did not significantly differ from the age of patients with alcoholic liver steatosis (p>0.05). There were 43 smokers (19.1%) -less than among people with liver steatosis on the background of ALD (p<0.001). Among patients with liver steatosis in NAFLD, there were more women - 180 (80.0%), and men - 45 (20.0%) (p<0.001). In patients with alcoholic hepatic steatosis, diseases of the stomach and pancreas, chronic obstructive pulmonary disease (p<0.001) prevailed among the comorbidities, while in patients with non - alcoholic hepatic steatosis, on the contrary, diseases of the cardiovascular system (p<0.05) and metabolic syndrome (p<0.001) prevailed. In alcoholic liver steatosis, 54.5% of patients had a BMI>25, and in non - alcoholic liver steatosis-97.8% (p<0.001). Conclusion: There is a relationship between the development of diseases of the stomach, pancreas, chronic obstructive pulmonary disease, diseases of the cardiovascular system, metabolic syndrome, excess weight and the etiology of FLD.