PATHOGENETIC ASPECTS OF METABOLIC FOLIC ACID DURING INTRAUTERINE GROWTH RETARDATION OF THE FETUS
The article presents the results of a study of genetic markers frequency folate cycle in 24 neonates with hypotrophic, hypoplastic types of intrauterine growth retardation. Systems studied polymorphic gene MTHFR (methylenetetrahydrofolate reductase): S677S, C677T, T677T; gene MTR (methionine synthase): A2756A, A2756G, G2756G; gene MTRR (methionine synthase reductase): G66G, G66A, A66A. The result of the analysis were established association of occurrence of intrauterine growth retardation neonates with gene polymorphism T677T MTHFR, G2756G MTR gene and gene A66A MTRR, especially important when hypotrophic variant of intrauterine growth retardation and boys.The study found the power of determination - low to A66A MTRR gene, the average – for the MTHFR gene polymorphism 677T. Determination of gene polymorphisms C677T MTHFR, A2756G gene MTR, MTRR A66A gene can be regarded as an objective criterion the risk of formation of intrauterine growth retardation. Identifying risk, genetic analysis of folic acid metabolism allows selecting an effective set of preventive of intrauterine growth retardation fetus.