Clinical features and genetic risk factors in the development of ischemic stroke
Aim: to study the clinical features of the progredient and crisis course of the cerebrovascular process complicated by ischemic stroke, with genetic associations of gene polymorphisms. Methods. A molecular-genetic analysis of the distribution of alleles and genotypes: (ACE (rs1799752), FGB (rs1800790), F5 (rs6025), F7 (rs6046), F12 (rs1801020), GP1BA (rs2243093), GPIIIa (rs5918), SERPINE1 (rs1799768), MTHFR (rs1801133), CYP11B2 (rs1799998), PON1 (rs662), PON2 (rs1801282), NOS2 (rs2297518), NOS3 (rs1799983), PDE4D (rs966221, rs2910829), HIF1a (rs11549465, rs11549467), LTA (rs909253), ALOX5AP (rs4769874), TUB (rs4578424).) - was conducted for each of the studied polymorphic regions of genes in groups of patients with stroke having different clinical manifestations. Results. The analysis of clinical features, the state of brachiocephalic arteries in patients with chronic cerebrovascular pathology complicated by stroke was carried out. Groups based on the nature of stenosis of brachiocephalic arteries, the pathogenetic subtype of stroke, and molecular genetic analysis, revealed that the allele of the C gene of the GP1BA gene is more common in the group of patients with occlusion of the BCA and severe hemodynamic stenosis (24%) than in the group of patients with hemodynamically insignificant stenosis (8%) (OR = 3.385, 95% CI = 1.118-10.248, p = 0.03). It was found that the allele D of the ACE gene is more common in the group of patients with cardioembolic stroke (67%) compared with patients with atherothrombotic stroke (38%) (OR = 3.333, 95% CI = 1.174-9.464, p = 0.026).