Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas
Membrane type 1 matrix metalloproteinase (MT1MMP) is one of matrix metalloproteinases (MMP),
 which play а key role in tumor invasion and metastasis. The aim of this study was to elucidate the
 peculiarities of expression of MT1MMP and endogenous regulators of its activity: the activator – furin
 and the inhibitor – TIMP-2, as invasive factors of squamous cell cervical carcinomas (SCC). The study
 was carried out using 11 specimens of SCC and 11 specimens of morphologically normal tissue adjacent
 to the tumor. It was shown that the increase of MT1-MMP and furin expression and low of TIMP-2
 expression makes the main contribution to the destructive (invasive) potential of SCC. Moreover,
 substantial expression of MT1-MMP was registered in the specimens of morphologically normal adjoining
 to tumor tissue. This expression was found to make an additional contribution to the destructive potential
 of the cervical tumor.