Herpesviridae and long-term subfebrility
Objective. To assess the clinical value and pathogenetic significance of herpesviruses in the development of longterm subfebrility in children. Subjects and methods. One hundred and twenty-seven children aged 6 months to 15years with long-term (3-week to 48-month) subfebrility were followed up. The children were admitted to the infection wards of the Central Clinical Hospital, the Morozov Children's Clinical Hospital, and the Russian Children's Clinical Hospital (Moscow). Results. Herpesvirus infection (HVI) markers were revealed in 112 (88.2%) children. Ofthem, 7(6.3%), 34 (30.4%), and 71 (63.3%) children were diagnosed as having acute, reactivated, and latent HVI, respectively. Conclusion. The clinical syndrome of long-term subfebrility should be considered to be one of the symptoms of an infectious disease running as a latent persistent process, less frequently as an active one.