ANALYSIS OF THE LEVEL OF ENDOTHELIN-1 IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA WITH AND WITHOUT THE SYNDROME OF DEPENDENCE ON ALCOHOL
In a basis of the pathogenesis of development and progression of benign prostatic hyperplasia (BPH) is a large number of pathogenetic and medico-social factors. The aim of this study was to analyze the endothelin-1 level in 72 patients with BPH with and without alcohol dependence syndrome at the age of 40-50 years and 51-60 years. As a comparison group 30 somatically healthy male subjects were examined. The level of endothelin-1 in all subjects was determined in blood plasma samples. It was found that the level of endothelin-1 in patients with BPH with and without alcohol dependence syndrome in both age groups was higher than in somatically healthy individuals. In patients with BPH with a syndrome of alcohol dependence in all study groups, the endothelin-1 level was higher than in the group of patients with BPH without alcohol dependence syndrome. The highest level of endothelin-1 was in the group of patients with BPH with a syndrome of alcohol dependence at the age of 51-60 years. Increased endothelin-1 indicates a disruption of vascular endothelial function in patients with BPH. According to the results of the performed analysis, the age of patients and alcohol abuse influence the disturbance of vascular endothelium function in patients with BPH.