АРОРТIС- INDUCTOR - PROTEIN P53 AND INSULIN RESISTANCE IN METABOLIC SYNDROME
Apoptosis inductor activity - protein 53 and insulin resistance in 270 patients with metabolic syndrome of the age from 30 to 60 (162 men and 108 women) was studied. Apoptosis inductor - protein 53 concentration, insulin content by ELISA method were determined; index of, insulin resistance (HOMA-IR) was calculated according to formula - glucose (mmol/l) х insulin (mkEd/ml) / 22,5. Apoptosis inductor - protein 53 concentration is increased in patients with metabolic syndrome and is equal 1,59 (1,36; 1,91) U/ ml. Significant positive contact was revealed in patients with metabolic syndrome between concentration of protein p53 and insulin, protein p53 content and HOMA - IR (r+0,7, р< 0,05; r+0,84, р< 0,05).