POSSIBLE MECHANISMS OF PROCESSES REGULATION OF PROLIFERATION, DIFFERENTIATION AND APOPTOSIS IN NEUROBLASTOMA
Our experimental results and published data indicate that the regulation of proliferation, differentiation and apoptosis can occur in neuroblastoma cells induced by sublethal concentrations of a wide variety of substances including the ionic composition of the culture medium. Cell cycle and differentiation of cells can be controlled by cyclins and cyclin-dependent kinases. However molecular mechanism that responsible for cellular differentiation is bed understanding. A simple model for the enzyme regulation with binding sites for organic substrates and for inorganic ions. This enzyme activity is dependent not only on the presence of the substrate, but also on intracellular activities of inorganic ions. Сytoplasmic ionic composition can realize fine regulation of various cells enzymatic systems.