Hydrogen Peroxide Stimulates Exocytosis of von Willebrand Factor in Human Umbilical Vein Endothelial Cells
The aim of our research was to study the influence of hydrogen peroxide on the exocytosis of von Willebrand factor (vWF) in human umbilical vein endothelial cells (HUVEC). We have found that H2O2 at a non-toxic concentration (100 mM) increases the amount of vWF secreted by HUVEC by 43 ± 14% over control (p p 2O2 (p 2O2 causes an increase in the number of these dots and the appearence of the strings of vWF which are absent in control HUVEC. It is suggested that H2O2 may serve as a messenger which stimulates vWF exocytosis.