Polymorphism of HLA DRB1 genes in pregnant women with severe influenza A(H1N1)PDM2009
Frequency of HLA-DRB1 locus was studied in 163 cases of influenza A (H1N1) pdm2009 pregnant. Genotypes HLA DRB1*01*04, DRB1*07*08, DRB1*11*13 showed a protective role from influenza AH1N1pdm2009 (р<0,05). Polymorphism HLA DRB1*07*15 was associated with severe complicated flu (H1N1)pdm09 (RR = 3,4; 95 % CI 0,8-7,5). Genotype DRB1*16*16 was observed only in one near miss case of influenza in pregnancy.