PHENOTYPE OF PROLIFERATING TUMOR CELLS AND MICROENVIRONMENT IN DIFFERENT CLINICAL AND MORPHOLOGICAL VARIANT OF CLASSICAL HODGKIN LYMPHOMA
In the study degree of tumor aggressivity was estimated depending on state of tissue microenvironment by using morphologic (routine histology, immunohistochemistry, immunofluorescence) methods and statistical analysis. Proliferative activity of tumor cells in different types of classic Hodgkin lymphoma (HL) was compared with composition and activity of nontumorous microenvironment cells. Specimens of lymphocyte rich, mixed cellularity and reticular type lymphocyte depletion HL were used in the study. Nuclear Ki-67 expression was observed in tumor cells as well as in nonactivated and activated T-lymphocytes, activated B-lymphocytes of microenvironment. Examined HL tissues have different proliferative activity of tumor cells and cells of microenvironment. It was determined that phenotype of proliferating and thereby the most aggressive tumor cells depend on HL variant and composition of its microenvironment.