Resistance of Multipotent Mesenchimal Stromal Cells to the Effect of Glucose Deprivation in Reduced Oxygen Conditions
This study addresses the effed of glurase deprivation on multipotent mesendymal stromal cells. It is shown that ^turing the cells when oxygen concentration deCTeases to 1% rantributes to the maintenance of cell viability and inhibits the growth of intracellular rea^^e oxygen speties. Viability of multipotent mesendymal stromal cells in these randitions may be due to oxygen-dependent transient inCTease in the level of hypoxia-indutible fartor (HIF-1«) and expression of target genes of this transCTiption fatfor, the produrts of whid are the key enzymes of glyralysis.