Significance of discovery H. pylori antigens into peptic and duodenal mucous membrane during complicated duodenal ulcer
Correlation of H. pylori with complications of duodenal ulcer has not been studied enough. The objective of our research is to analyse the correlation of H. pylori antigens with peptic and duodenal mucous membrane in patients with complicated duodenal ulcer. The method used in our research is immunohistochemical staining of histological material of peptic and duodenal mucous membrane. In 100% cases there were antigens in biopsies in patients with perforated ulcer, in 51,7% - in patients with bleeding gastric ulcer, in 58,7% - in patients with stenosing ulcer of stomach, in 75,0% - with uncomplicated duodenal ulcer, 72,7% - in case of refractory ulcer. Perforated ulcer was studied to have the highest antigens occurrence in infiltrate cells of submucous membrane (33,3%). Incidence of antigens detection inter and intra epithelial cells at scarring was 57,1% as reliably compared to the period of exacerbation (23,8%) and 3 months later or more after ulcer healing (15,0%) (p=0,046). Incidence of antigens detection in infiltrate cells at scarring was 35,7% as reliably compared to the period of exacerbation (4,8%) and 3 months later or more after ulcer healing (5,0%) (p=0,04).