CHRONIC OXIDATION STRESS AND BIOTRANSFORMATION OF ENDOTOXINS IN PATIENTS WITH FOCAL IMPAIRMENT OF NEUROLOGICAL FUNCTIONS
The goal of this investigation was measuring a number of biochemical parameters of the oxidation stress and activity of the semicarbazide-sensitive amine oxidase in blood serum of patients with focal brain impairment caused by hemispheric ischemic stroke. Material: 30 patients (average age 69±8 years, 18 females and 12 males) four to five months after the ischemic stroke. In patients blood serum and in healthy volunteers, the researchers measured the levels of middle molecules (MM) and malonic dialdehyde (MDA) and the activity of the semicarbazide-sensitive amine oxidase (SAO). An associated increase of the MM level and the ultimate product of lipid peroxidation and MDA in patients group, in comparison with the norm, pointed to development of a chronic oxidation stress 4 to 5 months after the stroke. Increased catabolism (higher MM levels) was accompanied by increased SAO-activity, which was confirmed by a significant positive correlation (MM-level/ SAO-activity: rs = + 0.8, p=0.002) in the patients group. Thus, the development of the chronic oxidation stress in patients with focal brain impairments leads to disturbances in the detoxification metabolism, specifically, detoxification of endogenous substances with SAO, which, in its turn can trigger off a number of pathochemical reactions associated with problems of neurological functioning recovery.