First results of clinical use of direct gene therapy VEGF and bFgF for treatment of patients with chronic ischemia of lower limbs
The article shows the results of using the double cassette expression plasmid vector pBud-VEGF165-FGF2 for patients with peripheral arterial diseases (PAD): 10 men with PAD experienced intramuscular injection of studied medication to the affected limb. Foe explaining the findings was used the measurement of ankle-brachial index (ABI), treadmill test, recovery period of initial ABI after pressure, immunohistochemical study. Was recorded an improvement in functional status of limbs after using treatment by 19% according to ABI, an increase in walking distance twice, reduced time to restore the original LPI by 38%. According to immune histochemical study was recorded an increase in density of capillary network up to 47.9%.