CHRONIC LYMPHOCYTIC LEUKEMIA
B-cell chronic lymphocytic leukemia is a clinical and biological heterogeneous group of neoplastic diseases. By the time of a disease diagnosis nearly 70 % of patients were aged 65 and older, the majority of them by then were having several associated diseases. Treatment results depends from biology of leukemic cells, chemotherapy toxicity and comorbidity. The goal of therapy has been to maintain the best quality of life and treat only when patients become symptomatic from their disease. Although chronic lymphocytic leukemia remains incurable, over the past decade there have been major advances in understanding the pathophysiology of CLL and in the treatment of this disease We review the diagnostic and treatment options in this article.