SCALE OF RISK OF CORONARY ATHEROSCLEROSIS AT PATIENTS WITH OBESITY
In recent years the role of visceral fat tissue and tens adipokins in risk of coronary atherosclerosis is studied. But scales for stratification of coronary risk don´t consider the main pathogenic mechanisms connecting obesity with cardiovascular complications. Research objective to create a scale of risk of Subclinical Coronary Atherosclerosis at Patients with Obesity (SCAPO). Material and methods: Research included 67 men, 40-65 years (50,95±6,54 years) with absence of clinic of coronary heart disease and clinical manifestations of atherosclerosis of other localizations. Patients had the obesity of the I-III degree, BMI 35,16±3,32 kg/m² and visceral obesity on an indicator of thickness epicardial fat tissue≥7 mm. As a result of carrying out a coronary angiography or a multispiral computer tomography of coronary arteries 2 groups of comparison were allocated: Group I (n=25) - patients with existence of coronary atherosclerosis, Group II (n=42) – patients with absence of coronary atherosclerosis. Results: Potential predictors of risk of coronary atherosclerosis as a result of comparison of two groups became: existence of an arterial hypertension, existence of carbohydrate violations, triglycerides, leptin, adiponectin and C -reactive protein. As a result of the regression analysis with optimal scaling importance coefficients are appropriated to each predictor. The size of right classifications as a result of logistic regression made 79,1% that speaks about good predictive ability of this regression model. Conclusion: The scale of SCAPO allows to estimate risk of coronary atherosclerosis in the absence of disease clinic that is important within timely preventive actions and the prevention of progressing of a disease.