ANTIHYPOTHERMIC AND ANTIOXIDANT PROPERTIES OFGLUCOSAMINE HYDROCHLORIDE AND ACETYLSALICYLIC ACID IN ACUTE COLD INJURY
In acute experimental cold injury in rats such pathological changes were observed as an increased intensity of lipid peroxidation and antioxidant system in blood serum and liver homogenates, which could be explained by the damaging effect of hypothermia and compensatory activation of antioxidant protection. After a prophylactic administration of frigoprotectors, namely glucosamine hydrochloride at a dose of 50 mg/kg and acetylsalicylic acid at a dose of 25 mg/kg, there was a significant decrease in the degree of hypothermia and the reduction of the intensity of free radical oxidation of lipids as well as indicators of antioxidant system in blood serum and in liver homogenates of rats. The most pronounced frigoprotection and antioxidant effect was observed against a background of glucosamine hydrochloride. The data obtained indicate a significant protective properties of the investigated drugs in acute cold injury.