Features of hypogonadotropic hypogonadism in women with hyperandrogenism in reproductive period
The goal of research: to study clinical-diagnostic manifestations of hypogonadotropic hypogonadism in women with hyperandrogenism in reproductive period.Materials and methods: 25 women with hipergonadotropic hypogonadism (HH) and hyperandrogenism (HA) were examined. The comparative group included 20 practically healthy women of reproductive age. The incidence of chronic somatic diseases in women with HH and HA was stu-died. There were examined the indicators of hormones of hypothalamic-pituitary- adrenal-ovarian axis, including Follicle-stimulating hormone (FSH), Luteinizing hormone (LH), Thyroid-stimulating hormone (TSH), relation of LH/FSH, Prolactin, Cortisol, 17 oxyprogesterone (17 OP), Dehydroepiandrosterone sulfate (DHEA-S), total testosterone (T), free T3, free T4, estrone (E1), estradiol (E2), sex hormone-binding globulin (SHBG). Blood levels of hormones were determined with chemiluminescence.The results of the study. It was determined that women with HH and HA had the indicator of hirsutism equal to 17.44±0.97 (14-24) points, hormonal number equal to 13.7±0.86 (9-20) points. Indifferent number was about 3.33±0.29 (2-4) points.It was revealed that the presence of hypothalamic dysfunctions in women with HH and HA is the result of functional failures including: rheumatism and rheumatoid arthritis - 76%; chronic tonsillitis - 84%; anemia - 72%; chronic enterocolitis - 48%; anorexia nervosa - 32%; chronic pneumonia - 24%.The study of hormone levels revealed statistically reliable reduction of FSH (3.72±0.32 mME/ml), LH (2.64±0.21 mME/ml), relation of LH/FSH (0.71±0.03), E2 (37.7±1.99 pg/nl), SHBG (25.52±6.1 nmol/l),AMG (2.29±1.1 ng/ml), and increase of androgens (3.55±0.33 ng/ml), 17-OP (0.64±0.08 ng/ml) andtotal testosterone (0.93±0.25 ng/ml).