ANTIRETROVIRAL RESTRICTION FACTOR TRIM5α: MECHANISMOF ACTION AND PROSPECTS FOR APPLYING IN HIV GENE THERAPY
The TRIM5α protein is an intracellular antiretroviral restriction factor. The TRIM5α activity provides the resistance of Old World monkeys to HIV-1. This fact defines the potential for applying TRIM5α for HIV-1 treatment. In this review, we summarize the existing knowledge about the mechanisms of TRIM5a-mediated suppression of HIV-1 and discuss TRIM5a's potential to be used in gene therapy.