Analysis of the effect of extreme temperature on the half-finished product of the live plague vaccine in various periods of storage of the finished preparation
The loss of certain percent of viability during the first year of storage of the live plague vaccine promotes accumulation of inviable «ballast» and reduction of immunogenic effect of the calculated dose of the preparation. The way to stabilize the number of viable calls in the vaccine preparation at the expense of the «cull» of weakened or defective individuals by keeping samples of the half-finished product at the raised temperature of (37±1) °