Rapid eye movement sleep behavior disorder after deep brain stimulation in Parkinson’s disease
Deep brain stimulation improves motor symptoms of Parkinson’s disease, but the effect of stimulation on nonmotor symptoms is not well known. Sleep disorders are among the most common nonmotor symptoms of Parkinson’s disease. Rapid eye movement sleep behavior disorder takes a special place among sleep disorders. Diagnosis and treatment of this disorder is very important. Here we discuss the effects of subthalamic nucleus deep brain stimulation on rapid eye movement sleep behavior disorder in patients with Parkinson’s disease. The subthalamic nucleus could be associated with the nucleus that regulates rapid eye movement sleep. Microlesion made by the electrode responsible for triggering the observed rapid eye movement sleep behavior disorder. Patients with better anatomical positioning in the subthalamic nucleus may have a greater chance of developing rapid eye movement sleep behavior disorder. The use of melatonin and clonazepam little effective in these patients. We offer an alternative method of treatment of disorders using acetylcholinesterase inhibitor.