The state of the oculomotor system in patients with endocrine ophthalmopathy according to clinical and computer tomography examination results
165 patients (330 eyes) with endocrine ophthalmopathy (EOP) treated at the Filatov Institute received clinical examination and computer tomography examination of the orbit. Of these, 107 (64,85%) were female and 58 (35,15%) male. The patients’ age ranged from 18 to 83, with the average age being 51,9±13,9 years. Restricted «clinical» eye mobility was shown to significantly correlate with an increase of all extraocular muscles (EOM), especially the inferior rectus (p=0,00001) and the internal rectus (p=0,00006) muscle (r = 0,24 и 0,25, р=0,000), Mobility restriction is revealed either in one direction (53,9% of eyes) or simultaneously in several directions. The restriction frequently affects both eyes (62,6% of cases). It has been established that the restricted clinical mobility in EOP patients occurs more often in the upward direction (73,03%) and the outward direction (54,85%). EOP patients show a siginficant correlation between the restriction direction of eyeball mobility and the increased thickness of EOM, The upward restriction of clinical mobility is associated with the increase of the inferior (р=0,00015) and the internal (p=0,02) rectus muscles, whereas the downward restriction correlates with the increased thickness of all muscles, especially the superior (p=0,00002) and the external (p=0,0001). The outward restriction is also associated with the increased thickness of all muscles, primarily the inferior (р=0,00001) and the internal (р=0,0000), while the inward restriction is associated to a greater extent with the increased thickness of the external muscle (р=0,00001) and to a lesser extent with that of the inferior (p=0,05) and the superior (p=0,04) rectus muscles of the eye. The thickness of the extraocular muscles in patients with EOP shows a significant increase (by 1,3 - 1,7 times) as compared with the normal values (p=0,0001) both in cases when the «clinical» mobility is violated and when it remains unaffected. EOM thickness determined by CT significantly depends on the activitiy and the severity of the disease (р=0,00000). The restriction od clinical mobility showed a significantly more frequent occurrence (2=8.92; р=0,01) in patients with endocrine myopathy (EM) - 92,5 % of eyes and edematous exophthalmos (EE) - 85,1%. The average thickness of all EOM exceeded the norm in all clinical forms of EOP, achieving the maximum size in EM. The maximum significance of difference between the average thickness values was observed in the inferior (F=7,62; p=0,0006) and the internal (F=6,09; p=0,003) EOM in differeni clinical forms of EOP // Russian Ophthalmological Journal, 2015; 1:25-30.