Content of nitrogen oxide and its metabolites in blood and esophageal mucosa in children sickly with respiratory diseases against the bachground of gastroesophagial reflux disease
Actuality. Nitric oxide provides vasodilatation of blood vessels, regulation of microcirculation, regulation of synthesis and secretion of hormones that affect the gastrointestinal motility (gastrointestinal tract), gastric secretion. There are few studies which confirm gastroprotective effect of this mediator. In other researches signed disorders of stomach motility when blocking NO-synthase. The aim of research - to set the level of nitric oxide and its metabolites in blood plasma and esophagus mucous membrane in children with frequent respiratory diseases (FRD) and gastroesophageal reflux disease (GERD). Materials and methods. 150 children of puberty age were examined and divided into three groups - children with frequent respiratory diseases (FRD) and concominant gastroesophageal reflux disease (90 children, group 1), children with FRD without GERD (30 children, group 2), healthy children (30 children, group 3). Abstract. A significant increase of total NO (29.5%) in children with RRI and GERD, NO2 metabolite (27.4%) and NO3 metabolite (40.2%) was established. It has been found that frequent respiratory infections accompanied with significant increase of total NO and its metabolites in esophageal mucosa - total NO - 2.16 times, NO3 - 2.1 times, NO2 - 1.59 times, p<0.05; however, in RRI without GERD there is no significant difference revealed. After regression analisys it was set direct linear relations between the content nitric oxide and its metabolites in esophagus mucous membrane and blood plasma. The regression between total NO level in plasma and esophagus mucous membrane was r=0.30 (p<0.05), NO2 - r=0.29 (p<0.05), NO3 - r=0.34 (p<0.05). Conclusion. It was set the probable increase of nitric oxide in blood plasma and esophagus mucous membrane in GERD, positive correlation between NO and its metabolites NO2 and NO3 in plasma and mucous membrane.