ANTIOXIDANT ENZYME GENE POLYMORPHISM IN CHRONIC PERIODONTITIS
The parameters of the destructive process of periodontal tissue of 70 patients with chronic generalized periodontitis of moderate severity with disease duration from 4 to 12 years in age from 32 to 54 years who were treated in the Republican dental clinic and dental clinic number 3 of Saransk. Investigated the intensity of lipid peroxidation and the frequency of occurrence of gene polymorphisms of antioxidant enzymes superoxide dismutase, catalase, and glutathione S-transferase P1 in patients with chronic periodontitis. In the genomes of patients with periodontitis revealed increased incidence of pathological alleles superoxide dismutase, glutathione S-transferase. Shows association with the risk of developing chronic periodontitis gene mutations Ala16Val superoxide dismutase and glutathione Ala114Val gene S-transferase. These data suggest an important role in the implementation of the free radical mechanism of disease pathogenesis, causes a high risk of damage to cell membranes, the development of destructive processes and cell death, which is the basis for the study of the genetic component associated with the presence of polymorphisms in the genes of enzymes that affect the efficiency of the antioxidant defense in the body patients.