Non-Alcoholic Fatty Liver Disease: a Modern Approach to the Problem
Over the last years, nonalcoholic fatty liver disease becomes the most common among chronic liver diseases. Here we outline modern understanding regarding causes, mechanisms of its development, relationships with metabolic syndrome, and genetic factors. The major modifications in therapeutic strategies shaped in recommendations of European and American associations on management of patients with nonalcoholic fatty liver disease are presented. A therapeutic approach, role of non-medicated methods to be used as a first line therapy, and efficacy of pathogenetic treatment are discussed by considering evidence-based data analysis.