The State of Endogenous Antimicrobial Peptides in Patients with Acne
The objective of the study was to determine the content of alpha-defensins in the blood of patients with acne and to determine the effect of their functional state on the course of the disease. The methods of investigation are general clinical, immuno-enzymatic, and statistical. Results. A remarkable increase in blood levels in patients with acne of alpha defensins (HNP 1-3) was revealed in comparison with the parameters of the control group of healthy individuals, which may indicate a violation of the mechanisms of the knotted tolerance of the skin microbiota in this disease and compensatory response to this from the system of antimicrobial peptides (alpha-defensins). Conclusions. An increase in the level of alpha-defensins in the blood of patients with acne is a reaction of the innate line of defense of the organism in response to excessive microbial colonization of the sebaceous hair follicles with the involvement of various types of skin cells to it, which requires consideration when assigning complex therapy to such a patients.