STUDY OF THE ANTI-BURN EFFECT OF SOFT DOSAGE FORMS BASED ON CARBON DISPERSED MATERIAL
The search for new anti - burn and regenerating agents is an urgent direction of modern regenerative medicine. The research purpose is to evaluate the anti - burn activity of soft dosage forms with Carbon dispersed material is a nano - diamond powder (TU 19386389 - 001 - 2022 made by Promtechservice LLC, Stavropol). Materials and methods. Burn injury was simulated in Wistar rats. Soft dosage forms were obtained in an experimental laboratory using standardized pharmacologically neutral bases (hydrophilic - gel, emulsion - cream), the concentration of active substance was 0.5% by weight, the method of introduction into the base was suspension. The studied dosage forms (cream and gel) and the bases used in their manufacture were applied in a thin layer to the burn defect during the 21st day. On the 3rd, 7th, 14th and 21st days of the experiment, blood was taken from rats to determine the content of white blood cells and changes in the area of the burn were assessed. Results and its discussion. It was found that the application of the studied gel on the 14th day of the experiment led to a decrease in the burn area by 29.8% (p< 0.05), whereas when applying the cream, this indicator decreased by 27.5% (p<0.05). On the 21st day of the study, the application of the studied dosage forms (cream and gel, respectively) contributed to a decrease in the magnitude of the burn defect by 39.9% (p<0.05) and 25.6% (p< 0.05). It is worth noting that by the 21st day of the study, complete normalization of the leukoformula was noted in animals; they were treated with the analyzed dosage forms. Conclusion. The conducted work has shown that soft dosage forms with Carbon dispersed material have an anti - burn and regenerating effect in conditions of burn injury in rats, which actualizes the further development of topical dosage forms containing Carbon dispersed material.