Morphological changes in the lungs and intrathoracic lymph nodes in the drug-resistant tuberculosis
We studied the morphological changes in the lungs and intrathoracic lymph nodes in drug-resistant fibro-cavernous pulmonary tuberculosis. We have studied autopsy material of 66 patients who had died at the age of 25 to 70 years, 36 of them died of drug-resistant fibro- cavernous pulmonary tuberculosis, 30 of fibro-cavernous pulmonary tuberculosis with preserved drug-sensitivity (control group). There are several features characterizing morphological changes in drug-resistant fibro-cavernous pulmonary tuberculosis, they show a significant increase in the volume density of caseous-necrotic component, reduction of volume density of lymphoid infiltration in the lung tissue, the morphological features of diminished reactions of T-cell immunity in the lymph nodes.