PATHOLOGICAL CHARACTERISTICS OF SEPTICEMIA IN MODERN ANTIBACTERIAL THERAPY
Sepsis is an urgent problem for modern health care, which is associated not only with frequent development and high mortality, high cost of care, but also with inconsistency of definitions, as well as pathomorphosis of changes in connection with multi-component and often long-term treatment. We examined archival material of 93 autopsies of deceased with a clinical diagnosis of sepsis. Microscopic examination assessed the frequency of occurrence among observations and the prevalence of signs of damage to the vessels of the microvasculature, as well as the parenchyma of organs: myocardium, liver, kidneys, and brain. Statistical processing of the data obtained was carried out to determine significant differences between the observation groups. In the course of the study, it was revealed that macro- and microscopically distinguishable abscesses, which are an undoubted morphological sign of sepsis, occur only in 15% of deaths with a clinical diagnosis of sepsis, in 23% septic metastasis is minimally pronounced and is represented by single microscopic perivascular infiltrates - mini-foci, which can be regarded as a variant of setcemia in patients with a hyperergic response to a gram-negative infection, and in some cases - in those who died with prolonged antibiotic treatment.