COMBINED EFFECT glucosamine hydrochloride with paracetamol morphology of articular cartilage EXPERIMENTAL RATS WITH corticosteroid dystrophy
The data results pharmacotherapy acetaminophen, glucosamine hydrochloride and a set of white rats with corticosteroid dystrophy. It is shown that modeling of this disease leads to complex structural disorders of articular cartilage accompanied at the tissue level low density of cells in all areas, the advent of acellular matrix territories and destruction. At the ultrastructural level is heterohromatyzatsiya core chondrocytes, the cells cytoplasm destruction, fragmentation granular endoplasmic reticulum tubules and severe vacuolization of cells. Pharmacotherapy animals corticosteroid dystrophy acetaminophen, glucosamine hydrochloride and their complex for 4 weeks led to a reduction in the intensity of manifestation of destructive changes in articular cartilage and promotes activation of biosynthetic processes in chondrocytes.