VASCULAR INFLAMMATORY PROTEINS IN CERVICAL CANCER PATIENTS
Prolonged inflammation is one of the triggers of many malignant tumors. The roles of some inflammatory markers are not yet studied in the process of carcinogenesis. The aim was to study the patterns of changes in some vascular inflammatory proteins in the blood of patients with cervical cancer different stages. The objects of study were the patients with cervical cancer I-IV stage. The average age was is 39 ± 9.8 years. The material of study was blood serum. The studied groups: NI - non-invasive cervical cancer (n = 8), IL - invasive localized cervical cancer (n = 18), MR - locally distributed cervical cancer (n = 19), G - metastatic cervical cancer (n = 4). Samples of the control group were taken from 15 gynecologically healthy women. The research method was flow cytometry FC500 using the Human Vascular Inflammation Panel 1 panel. Test parameters: myoglobin (MG), calprotectin (CAL), lipocalin A (LCN), matrix metalloperoxidase 2 (MMP-2), osteopontin (OPN), myeloperoxidase (MPO), serum amyloid A (SAA), protein 4, insulin-like binding growth factor (IGFBP-4), cell-cell adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule (VCAM-1), matrix metalloperoxidase 9 (MMP-9), Cystatin C (CC). Statistical analysis of the data was carried out using nonparametric statistics using the Mann - Whitney U-test. Low concentrations of MMP-2, MPO, SAA and IGFBP-4 were detected in the blood of the patients with metastativ cervical cancer. In contrast, the concentration of OPN in patients with G cervical cancer was maximum and amounted to 56.05 [6.95; 95.15] ng / ml. Significant differences were found between groups of patients with MR and G cervical cancer in concentrations of MMP-2, SAA, IGFBP-4 (p <0.05), between groups of IL and MR cervical cancer in ICAM-1 and VCAM-1 (p < 0.05). The results of our study can be used for research new differential criteria for staging cervical cancer.