TUMOR CELLS - TEST-OBJECT FOR EMPERICAL EVALUATION OF THE EFFECTIVNESS OF ANTICANCER THERAPY OF COLORECTAL CANCER
A comparative assessment of the dynamics of cell growth, proliferative and colony-forming activities, as well as chromosomal and genomic instability in cell cultures obtained from intra-operative samples of colorectal cancer patients carried out in our study. It was shown that cells with different cytogenetic characteristics have individual sensitivity both to 5-fluorouracil, cisplatin, tomudex, leucovorin, and to combinations of cytotoxic drug with immunomodulator.