SILICA-BASED GOLD NANOSHELLS: SYNTHESIS AND APPLICATION IN IMMUNOCHROMATOGRAPHIC ASSAY
The method for gold nanoshells synthesis was optimized for their use as a highly sensitive label in immunochromatographic assay. An immunochromatographic test system based on gold nanoshells as a visual marker was developed for early cardiomarker fatty acid binding protein (H-FABP) detection. The detection limit of the method in the case of gold nanoshells was more than 2 times lower than that of gold nanoparticles and amounted to 0.5 ng / ml for H-FABP