Clinical-immunological, virological and morphological interrelations at chronic hepatitis C.
Complex clinical, laboratory, virological, morphological and immunological investigations of 111 patients with chronic hepatitis C were carried out. Findings of patients with different stages of the disease were compared. It was noted the increase necro-inflammatory activity in liver tissue as well as the activation cellular and humoral immunity at the background of the decrease of viral replication while progressing of inflectional process. Besides, there was prevalent role of autoimmune mechanism in the liver injury at late stages of the disease.