CLINICAL AND STATISTICAL SIGNIFICANCE OF RESULTS OF CLINICAL TESTS AS CRITERIA FOR THE BETA-BLOCKER SELECTION FOR THE TREATMENT OF CHRONIC HEART FAILURE
The present article discusses issue of criteria for assessment of clinical and statistical significance of randomized clinical trials aimed to evaluation of drug efficacy, in particular, beta-blockers (BB). Such results allow us to change current clinical guidelines for the use of medicines. On the choosing of BB for the treatment of cardiovascular disease or prevention the development of complications, physicians should focus primarily on the clinical evidence of a particular drug use. Statistically significant reduction in the risk of development of the complications of cardiovascular diseases, as well as high clinical significance of the results, should be established in studies dedicated to evaluation of BB effectiveness.