INFLUENCE OF SHORT-TERM AND LONG-TERM ADAPTATION TO HIGH ALTITUDE ON THE PROCESS OF HEALING PURULENT WOUNDS IN EXPERIMENT
The nature of the course of the purulent wound process in the period of short-term and long-term adaptation to the highlands (3200 meters above sea level) was studied. Experiments were performed on 72 outbred rabbits. Experimental rabbits were divided into 3 groups: per 24 rabbits in each group. At ​​control group 1, the experiments were conducted under the conditions of the city of Bishkek (770 meters above sea level); experimental groups 2 and 3 of animals with 3-day and 30-day adaptation to the conditions of high mountains, the experiments were carried out on the Tuya-Ashuu pass (3200 meters above sea level). The nature of the purulent wound process of soft tissues is shown using the planimetric method, the rate of wound reduction, cytological examination and ultrasound monitoring. In the course of comparison, there is a significant lag in wound healing in experimental rabbits of group 2, in high altitude conditions. On the 15th day, the area of ​​wounds is as follows, in group 1 – 448.8 ± 10.18 mm2 (p < 0.005).In group 2 – 676.1 ± 63.10 mm2 (p < 0.005).and in group 3- 456.5 ± 18.39 mm2 (p < 0.005). On the 20th day, the wound area reduction of group2 averages – 398.5 ± 44.40 mm2 (p < 0.005). so as in the I group – 237.3 ± 29.20 mm2 (p < 0.005). and in group 3 – 303.8 ± 30.15 mm2 (p < 0.005), which shows that during the short-term adaptation to the highlands, a prolonged course of wound healing is observed compared with other experimental groups.