DIABETIC NEPHROPATHY: CURRENT ASPECTS OF DIAGNOSIS AND THERAPY
The article presents an analysis of current literature data on diabetic nephropathy (DN): definition, classification, pathogenesis and morphological changes. Modern early prognostic markers of DN are presented: MAU, Cystatin C, microRNA. The frequency, pathogenetic relationships of DN and concomitant diseases, the common risk factors and therapeutic approaches are revealed. Potential mechanisms leading to kidney damage in DM, dyslipidemia, and hypertension and their negative effects on the course and outcomes of DN are presented. The results of numerous studies are devoted to the treatment of patients with DN in association with obesity, CVH and hypertension.