SPECTROPHOTOMETRIC АNALYSIS OF THIRD-GENERATION CEPHALOSPORIN ANTIBIOTICS BY REACTION WITH Cu (II)
The possibility of cefotaxime sodium and ceftriaxone sodium determination has been studied by visible spectrophotometric method, based on the colored complexation products formation in reaction of β-lactam antibiotics with Cu (II) ions. It has been shown that this technique allows the detection of cefotaxime sodium in solutions containing from 8∙10-5 to 2,5∙10-3 mol/l of the drug, but it is inapplicable for ceftriaxone sodium. Stable results were obtained with a reaction time of 15 to 25 minutes.