Variant rs2009262 EFEMP1 Is Associated with the Developmentof Umbilical Hernia but Not with Postoperation Hernia in Russians
This study investigated whether rs2009262 EFEMP1 and rs3809060 WT1 single nucleotide polymorphisms are associated with anterior abdominal wall hernia. DNA samples were obtained from 253 patients with anterior abdominal wall hernia (60 males, 193 females, 82 patients with umbilical hernia, 171 patients with postoperative hernia) and 240 age-matched healthy controls (52 males, 188 females). Genotyping was performed by TaqMan-based PCR. Detecting of associations between SNPs and hernia risk was performed by logistic regression analysis. We found that the polymorphism rs2009262 EFEMP1 is associated with decreased risk of hernia after adjustment for age and gender (OR = 0.74, 95% CI = 0.56–0.98; P = 0.034). The stratified analysis showed that rs2009262 EFEMP1 is associated with decreased risk of disease only in patients with umbilical hernia (OR = 0.57, 95% CI = 0.37–0.88; P = 0.008). Meanwhile no association between rs2009262 EFEMP1 and postoperation hernia was observed. Our study showed, for the first time, an association of rs2009262 EFEMP1 with lower risk of umbilical hernia in Russians.