Allostatic load concept as a mechanism for evaluation of the influence of climatic factors on thyropathies formation In the population of Primorsky Region (case study population of Vladivostok)
Purpose: to assess the cumulative effect of monsoon climate factors of Primorsky Region on the formation of thyroid strain from the point of view of the concept of allostatic load (for example, the population of Vladivostok).Materials and methods: the study of the mechanisms of formation of thyropathies (for example, residents of Vladivostok) associated with the regional monsoon climatic factors cumulative seasonal loads in the light of the new concept of allostasis and allostatic load was performed in Primorsky Region. for this purpose, in 2003-2012, 7 parameters of the thyroid gland were analyzed in 9169 residents from different areas of Vladivostok. Canonical methods, regression and frequency analysis were used to investigate the connection of the thyroid gland (TG) functional state with 17 weather and climatic parameters for the specified period.Results: Autoimmune response in the form of the increased levels of autoantibodies to thyroid peroxidase and thyroglobulinregr(respectively, AT-TPO, AT-TG) was found to occur. The values of regression relationship (R= 0.26 and 0.24, p<0.02 andp<0.003, respectively) showed high statistical significance of association of thyroid autoantibodies formation with climatic factors of the region and revealed an indirect effect of the temperature gradient (the level of AT-TG) and weather conditions (at the level of AT-TPO, AT-TG), which can be regarded as system processes associated with sharp seasonal changes in quantitative values of monsoon climatic parameters during cyclones and formation of atmospheric fronts.Conclusions: high statistically significant association of thyroid autoantibody formation induction with climatic factors of the region suggested the possibility of risk formation of autoimmune thyropathies in residents of the region and to identify the allostatic load (stress and depression) on the immune system of the monsoon climate factors ща the Primorsky Region.