Experimental confirmation of expression mediators regulation of immune response in chronic exposure phenols
In this study, we assessed the aerogenic impact of phenols on immune regulation in children. The detected disorders of immune regulation are characterized by increased specific sensitivity to phenol and changes in the ability of monocytes to cytokine production. We proved the modulating action of phenol on cytokine production in ex vivo experiment. The experiment showed increase in the levels of IL-1β, IL-6, IL-8 induced by phenol and suppression in production of IFNγ, IL-17 induced by phenol in children of the observation group. We recommended specific immunoglobulin G to phenol and levels of IL-17, TNFα, IFNγ as sensitive markers of immune regulation in children exposed to phenols.