EPAC Proteins and Their Role in the Physiological and Pathological Processes in the Cardiovascular System. Part II. The Role of EPAC Proteinsin the Physiology and Pathology of the Heart
The second part of the review presents modern ideas about the role of Epac proteins in the regulation of inotropic and rhythmic functions of the heart, intercellular conjugation of cardiomyocytes and their apoptosis. The contribution of Epac proteins to the development of hypertrophy, fibrosis, and myocardial remodeling, as well as their role in the genesis of acute ischemic damage to the heart muscle and cardiac arrhythmias, is examined in detail.