THE INFLUENCE OF SANATORIAL SPA TREATMENT ON THE STATE OF ANTIVIRAL PROTECTION IN PATIENTS WITH BRONCHIAL ASTHMA
Bronchial asthma is a common chronic respiratory disease in children. Acute respiratory viral infections are the most common cause of exacerbation of this disease. Therefore, the aim of the study was to study the state of the interferon system in children with bronchial asthma at the stage of sanatorium resort rehabilitation. Interferon status was studied in 125 patients with bronchial asthma at the age of 7-17 years in the autumn winter period, both before and after corrective therapy. Changes in the levels of α- and γ interferons were detected in 84.4 % of patients. In 24 (22.6 %) children, a deficiency of α interferon was detected, in 48 (45.3 %) - γ interferon and in 34 (32.1 %) - a simultaneous decrease in α- and γ interferons. Initially, BA patients showed a decrease in the level of α interferon by 6.8 %, γ-interferon by 38.4 % (p<0.05). The first group of patients with bronchial asthma received a standard complex of spa treatment, the second - spa treatment and magnetotherapy, the third - spa treatment and human recombinant interferon alpha 2b in the form of rectal suppositories and in the form of a gel for external and local use ( on the surface of the nasal mucosa). The best result was observed in the group receiving spa treatment and human recombinant interferon alpha 2b: the level of alpha interferon increased by 74.7 % (p<0.01) and γ interferon - 2.1 times (p<0.001).