Influence of positive pressure ventilation on cerebral status of newborns in acute period of hypoxic-ischemic encephalopathy
Aim - to improve the quality of treatment of full term infants with hypoxic-ischemic encephalopathy (HIE) by choosing the best option of mechanical ventilation. To study the impact of mechanical ventilation on the cerebral blood flow, assessment of cerebral perfusion and systemic hemodynamics. Material and methods. Prospective, observational, multicenter, longitudinal cohort study included 115 children with severe HIE. Children had II and III classes of HIE based on Sarnat scale (modified by Hill A., Volpe J.J., 1994) were treated in the neonatal intensive care in 2007-2011. Results and discussion. Analysis and assessment of the impact of positive pressure ventilation on cerebral perfusion were examined and there was no evidence of negative correlation. Therefore, we can draw a conclusion of the safety of mechanical ventilation in preterm infants with severe hypoxic-ischemic encephalopathy. Conclusion. In current paper we summarized and solved actual scientific problems: improving the quality of treatment of full term infants with hypoxic-ischemic encephalopathy by choosing the best option of mechanical ventilation based on this study of its impact on the performance of cerebral circulation, assessment of cerebral perfusion and systemic hemodynamics.