STUDY OF MICE MYOCARDIUM ANTIOXIDANT SYSTEM''S WORK UNDER CONDITION OF VIBRATION STRESS
Features of mice myocardium pro- and antioxidant systems functioning under conditions of a vibration stress were studied.Experiments were made on not purebred male mice at about one age and weight that were contained in vivarium conditions on a usual diet. Animals were divided into 5 groups. Animals of 1-4 groups were exposed to daily thirty-minute vibration with frequencies of 8, 16, 24 and 32 Hz, with an amplitude of 0,8 0,12 mm within 14 days. Vibration of animals was carried out by the means of the electromechanical converter connected to the low frequencies signals generator. The fifth group of animals wasn't exposed to vibration and was used as control. Slaughter of animals was made after 14 day of influences. The sample of heart was homogenized with the subsequent centrifugation within20 min at 10000 g. Superoxide dismutase (SOD), catalase, glutathione peroxidase (GP), glutathione reductase (GR), glutathione-S-transferase (G-S-T) activities, the content of the reduced glutathione (GSH), SH groups and TBA- dependent products were determined in the homogenate using standard methods. Experimental data were processed with standard statistical methods.