NEUROPLASTICITY OF DIFFERENT PARTS OF THE CENTRAL NERVOUS SYSTEM OF WHITE RATS IN THE CONDITIONS OF ANTHROPOGENIC IMPACT MODEL
We studied different variants of the influence of various anthropogenic factors on the transformation of the protein Fund of associative neurons of the cerebral cortex, cerebellum, and spinal ganglia of the spinal cord of white rats. Alcohol, asphyxia and cellular conditions were used as models of anthropogenic factors. The influence of alcohol was studied on the example of neural populations of cells of layer II-III of the forebrain cortex, in which the object of study were nucleoprotein complexes. The influence of asphyxia was studied on the example of neural populations of the molecular layer, ganglion layer and dentate nucleus of the cerebellar cortex. In cerebellar neurons, common proteins were examined by interferometry. The effect of the conditions of cell content in white laboratory rats was considered on the example of neurons of the spinal ganglia of the cervical and lumbar spinal cord. Neurons of ganglia were analyzed for neurospecific structural proteins, which were detected by reaction with amidochernym 10B. as a control group in the third case were recruited semi-subterranean synanthropic gray rats. In experimental animals affected by alcohol, in comparison with control white rats, changes in the degree of chromophilia of nucleoprotein complexes were observed in neurons of the forebrain cortex. In white rats, under the influence of asphyxia in cerebellar neurons revealed changes in the number of total proteins. Changes in the content and concentration of neurospecific structural proteins were found in neurons of spinal nodes in laboratory rats experiencing conditions of cell content, in comparison with gray synanthropic rats.