The basic laws and features of cytokine dynamics in process and early terms after cardiopulmonary bypass
The basic variants of cytokines reactions defining type of organ dysfunctions are revealed in the course of cardiopulmonary bypass and in the early postoperative period. Their character and expression, depends on gravity preoperative an immunodeficiency and initial degree of heart insufficiency. Diphasic dynamics of development of system inflammatory reaction is confirmed after cardiopulmonary bypass: increase of levels proinflammatory cytokines is in the first phase and anti-inflammatory cytokines with development immunodepression and cellular anergy in is the second phase. Also, key role IL-1Ra is revealed in restraint of hyperactivation of system inflammatory reaction. Blood whey levels IL-6, IL-8, G-CSF, TNF-a and IL-1Ra should be defined to cardiopulmonary bypass, in 10-12 hours, 24 hours and 3 days after cardiopulmonary bypass and may be used as prognostic criteria of development of postoperative complications.