Clinicomorphological and biochemical specificities of chronic hepatitis C in the Sakha Republic (Yakutia)
The authors studied the clinicomorphological and biochemical specificities of the course of chronic hepatitis С in patients admitted to the Municipal Clinical Hospital of the city of Yakutsk. It was found that in the normal level of AIAT in patients with chronic hepatitis С (CHC) 6% of patients had moderate necrosoreparative activity of the process and 26% had moderate and severe fibrotic changes, which is indicative of the progressive character of disease. No reliable differences in the pathomorphological picture in the liver tissue were revealed in CHC patients with the normal and higher levels of alanine aminotransferase. Differences in the course of CHC were found in the native (Yakuts) and newly settled populations (Russians) of the Republic of Sakha (Yakutia): pain syndrome was more common in Russian patients; extrahepatic manifestations of chronic hepatitis C, hyperproteinemia and enhanced levels of thymol test were reliably more common in Yakut patients than in Russian ones.