ANTI-INFLUENZA VIRUS ACTIVITY OF AQUEOUS EXTRACT OF MACRO – AND MICROMYCETES IN EXPERIMENTS IN VITRO AND IN VIVO
Aqueous extracts of higher Basidiomycetes macromycetes and lower nematophagous fungus micromycetes were investigated with respect to their antiviral activity for cell culture MDCK and outbred white mice. Previously, it was found that all the samples studied are slightly toxic to fungal extracts of MDCK cell culture and laboratory mice. It was shown that most of fungal extracts inhibited reproduction influenza human and birds about 1.4 to 7,5 lg in preventive scheme and medicinal for cell culture MDCK. It was shown protective properties of fungal extracts of basidiomycetes studied in the medicinal preventive scheme, and at nematophagous fungus urgently preventive scheme in vivo. Of all the extracts tested macromycetes highest protection factor in an emergency medicinal preventive scheme was detected in extracts of the fungus Inonotus obliquus (20 %), whereas the maximum rate of protection from fungi extract Duddingtonia flagrans in the urgently preventive scheme at 65 %.