Effectiveness Of Cytological Diagnosis Of Cervical Epithelial Neoplasia And Cervical Cancer Based On The Tissue Sampling Method
Taking into consideration that false positive and false negative results can occur in the process of a study and of an assessment of cytograms, that are primarily related to poor quality of samples obtained, the major challenge would be to find the criteria that can ensure quality testing and an adequate diagnosis of precancerous lesions and cervical cancer. Objective of the study - is to evaluate the effectiveness of various types of special devices for cytology specimen collection from the cervix in the diagnosis of cervical intraepithelial neoplasia (CIN) and cervical cancer. Materials and Methods. 90 patients who visited the clinic of P.A. Gertsen Moscow Oncologic Research Institute - a Branch of Federal State Budgetary Institution «National Medical Research Center of Radiology» of the Ministry of Healthcare of the Russian Federation and Municipal Clinical Hospital № 57 named after D.D. Pletnev of Moscow Department of Healthcare underwent the examination for the period from September to December 2016. At the time of the investigation CIN I-III (LSIL-HSIL).was verified in each patient cytologically and/or histologically. The study was conducted using cytological and histological methods. Results. Cytological diagnosis defines the correct tactics of treatment in 97,5% of cases. Accuracy of cytological method in the collection of specimens from the cervix depends on the type of a special device that is used. When using Cervex-Brush® Combi and Cytobrush type F the accuracy of the method was 70%. When the samples are collected with spatula and Cytobrush type D separately the accuracy of the technique increases up to 96% (p < 0,05). The percentage of errors which entail incorrect tactics of treatment is three times as high as in cases when cervical cellular specimens are collected using Cervex-Brush® Combi (p < 0,05), and the percentage of errors which don’t affect the tactics of further treatment is twice as high as when Cytobrush type F is used (p < 0,05). Conclusion. Neither type of device for collecting cervical cellular samples proves to be perfect. The choice of particular cervical sampling device should be made based on the type of transformation zone, the size of an external cervical os and anatomical particularities of the cervix. The accuracy of cytological diagnosis of. CIN III and cervical cancer can be quite comparable to histological diagnosis provided that smear collection is performed adequately and obtained specimen is spread onto the glass slide correctly.