THE CONTENT OF MALODIATEHYDE IN PLASMA AND ERYTHROCYTE BLOOD MASS OF RATS UNDER CONDITIONS OF PESTICIDE INTOXICATION AND CORRECTION WITH VITAMIN E AND MILK THISTLE
Target. To study the change in the quantitative content of MDA in the plasma and erythrocyte mass of the blood of laboratory animals during intoxication with thiram and correction with antioxidant drugs - vitamin E and milk thistle. Methods. The experiment was carried out on 240 male Wistar rats, aged 2 months and weighing 200-220 grams. To solve the tasks set, the animals were divided into 8 groups of 30 animals in each group. The process of lipid peroxidation was evaluated by the quantitative content of MDA in the plasma and erythrocyte mass of the blood of rats by the spectrophotometric method. The results were expressed in µmol/mg. Results. On the basis of the study, it was found that during the period of subchronic thiram intoxication, an increase in the content of MDA in plasma and in the erythrocyte mass of blood was noted. Conclusions. With subchronic intoxication with thiram, activation of LPO processes is observed, which is expressed in an increase in the level of MDA in the blood plasma of rats. To maintain the prooxidant-antioxidant balance in pesticide intoxication, it is necessary to use antioxidant drugs.