Activity of superoxide dismutase, catalase and α-tocopherol content in blood serum of patients with type 2 diabetes complicated by steatohepatitis in combined treatment with Epifamin
The activities of aminotransferases, superoxide dismutase, catalase and α-tocopherol content in blood serum of patients with steatohepatitis developed in type 2 diabetes against a background of the basic treatment and combined therapy including Epifamin have been investigated. The decrease in superoxide dismutase activity and the increase in catalase activity in the pathology were revealed, that indicated the antioxidant system imbalance. Epifamin application against a background of the basic therapy resulted in a more significant changes of the activities of the enzymes studied, as well as α-tocopherol level toward the control values in comparison with the patients undergoing the standard treatment. Besides, the treatment with Epifamin strengthened the hepatoprotective effect of the basic therapy, which was evidenced by the most pronounced normalization of aminotransferases’ activities. The results indicate the positive action of Epifamin in its application during the basic treatment of steatohepatitis developed in type 2 diabetes. It is obvious that it is connected with the antioxidant effect of melatonin, whose level is corrected due to this preparation.