SYNTHETIC SEARCH FOR POTENTIALLY BIOACTIVE PRODUCTS FROM 2-METHYL-BENZENESULFONAMIDE
For the purpose of searching for potentially bioactive substances the synthesis of N,N-dichloro-2-methyl-benzenesulfonamide is performed. Its interaction with trichloroethylene results in the formation of a new highly electrophilic representative of N-sulphonyl imine polyhalogenaldehydes – 2-methyl-N-[(Z)-2.2.2-trichloroethyliden] benzenesulfonamide. A new representative of semiaminales – 2-methyl-N-(2,2,2-trichloro-1-hydroxyethyl) – benzene-sulfonamide is obtained by the condensation of 2-methyl-benzenesulfonamide with trichloroacetaldehyde. C-amidoalkylation activity of 2-methyl-N-[(Z)-2.2.2-trichloroethylidene] benzenesulfonamide with aromatic compounds has been studied in order to receive the substances containing pharmacophoric groups in their structure. The biological activity of the received compounds is predicted by means of the PASS computer program. The results are presented in the form of a table.