AGE ASPECT OF HISTOLOGICAL CHANGES OF THE ENDOMETRIUM WITH ABNORMAL UTERINE BLEEDING
The article analyzes the histological features of the endometrium among women with abnormal uterine bleeding: reproductive, perimenopausal and postmenopausal ages. The dependence of the occurrence of abnormal uterine bleeding on the woman's age is revealed. In the reproductive age, the histological structure of the removed endometrium is dominated by non-atypical endometrial hyperplasia. In the perimenopausal period, the incidence of non-atypical endometrial hyperplasia decreases, reflecting a decrease in estrogen levels. Among postmenopausal women, in 1/3 of cases, the removed endometrium contained atypical cells, which explains the hormonal independence of endometrial intraepithelial neoplasia and confirms the modern concept of the occurrence of uterine body cancer. It is recommended that all women with abnormal uterine bleeding have histological control of endometrial biopsy for the purpose of early detection of atypical changes in the uterus and timely treatment.