Prospect to increase the efficiency and tumorigenic safety of bone plastic materials with peripherally acting opioids
Opioid receptor agonists stimulate proliferation of osteoblast progenitors. Short-term phased use of proliferation stimulants first, and then osteoinductors, is observed the largest increase of bone regeneration volume. At that point the most promise have the officinal drug Dalarginum - peripherally acting delta- and mu- opioid receptor agonist. Data about the antitumor effect of opioids are controversial, so it is required further studies to evaluate the ability of opioids to inhibit proliferation, metastasis and invasion of different cell lines.