The content of the antimicrobial proteins in children with inflammatory diseases of the respiratory tract
We investigated the content of antimicrobial peptides in children with various pathology of the respiratory tract. It has been established that children with recurrent diseases of the respirotary tract are characterized by the changes of mucosal protection, low content of α-defensins 1–3 in oropharyngeal secretions. The revealed changes indicate the stress of the local defense mechanisms. The result of the investigation has revealed that overproduction of α-defensins 1–3 in children with recurrent bronchitis against the background of the disturbed balance between pro-and anti-inflammatory cytokines could be one of the reasons of recurrent forms of the respiratory tract infectio.