PREGNANCY COURSE AND HORMONAL STATUS OF WOMEN WITH HEPATIC FUNCTION IMPAIRMENT IN TRIMESTER III
Objective. Evaluation of pregnancy course and hormonal status of women their pregnancy was accompanied by the hepatic function impairment in trimester III was the objective of the study. Materials and methods. The pregnancy course and the hormonal values were analyzed in the blood serum of 97 women their pregnancy accompanied by the hepatic function impairment in trimester III (Group 1). The control group (Group 2) was formed of 29 women having no diseases of the hepatic-biliary system either before the pregnancy or during the pregnancy. The group of comparison (Group 3) consisted of 21 women suffering from chronic diseases of the hepatic-biliary system not accompanied by symptoms of exacerbation and hepatic function impairment during the period of pregnancy. Results. The liver functional state was determined to impact on the fetal-placental failure and gestosis occurrence in pregnancy trimester III. Pregnancy complicated by the hepatic function impairment is characterized by the placenta enzyme systems depression shown by the steroid producing function reduction. When the hormonal imbalance of woman's peptide hormones is evident being accompanied by cytolytic syndrome and hyperbilirubinemia it has been caused by the fetal-placental complex function disorders and deficit of factors stimulating their synthesis. Conclusion. Liver function abnormalities are caused by and effect the changes of hormones and are characterized by evident hormonal imbalance that may have adverse consequences for the fetus and affect its adaptation to extrauterine life.