Development of diphtheria epidemical process in Russia in conditions of high level of specific immunity
Analysis of the state of antidiphtheritic antitoxic immunity among Russian children, teenagers and adults was carried out on the basis of serologic monitoring in RF subjects. Protection level among children teenagers and adults was 96,2%-98,3% accordingly. Immunity stress toward diphtheria among the examined cohorts was high: medium and high antibody titers were found in 81,2%, 89% and 78,3% accordingly. The results of the control studies of adults' serums for the presence of antidiphtheritic antibodies also showed high factual protection of grown-ups against diphtheria (96,5%). Antidiphtherial immunity stress was also high: 82,5%-96,6% of the examined people had medium or high antibody titers. Thus the data of serologic monitoring agrees with the official data of population coverage with vaccination. In these conditions the incidence of diphtheria has sporadic character registered with low level with tendency of annual reduction. In 2008 51 people fell ill with diphtheria, among them there were 11 children, 4 teenagers and 36 adults. 15 patients had toxic forms of diphtheria. 2 grown-ups non-vaccinated against diphtheria died - the latter belonged to social risk group. Bacteriologic diagnosis confirmation was 74,5% in 2008.