DETERMINATION OF SILVER IN BIOLOGICAL SUBSTRATS FROM COWS BLV-INFECTION AFTER APPLICATION ARGOBIOCINE-2S
Submitted the quantitative determination of silver in peripheral blood and feces of cows infected with bovine leukemia virus (BLV) after intravenous and intramuscular injection of new introduction with the content of silver "Argobiocine-2S" having antiviral activity, using mass-spectrometry (ICP-MS). It is shown a sample preparation in blood by 100-fold the dilution mixture consisting of 0.1% Triton x 100, 0.1% HNO3 and internal standard of India as an alternative method of preparing this substrate for mass spectrometry method. The information on the accumulation and the timing of breeding of silver from the body allows judging about the level and duration of circulation of metal in the organism after injection "Argobiocine-2S" (over 72 h) and allows you to adapt the effective dose and course of treatment of animals.