Pharmacoepidiological study of the effectiveness of procaine (novocaine) in combination with other drugs in the treatment of pain syndrome in acute pancreatitis
The purpose of the study : on the base of statistical and pharmacoepidemiological researches to study the effectiveness of procaine (novocaine) and to develop optimal combinations of pharmacological agents in the treatment of pain in acute pancreatitis. Materials and methods . In a cohort retrospective research, we studied case histories of 131 patients with acute pancreatitis who were treated at Surgery Department of Archbishop Luka City Clinical Hospital of Tambov. Among them, 71 men (54.2 %) and 60 women (45.8 %), whose average age was 52.5, including 46 years old men and 59 years old women. We studied the number of medicines used to treat the pain syndrome, the time of its relief, and made a pharmacoepidemiological assessment of the effectiveness of treatment with novocaine in combination with various drugs. Procaine was injected intravenously in the form of a 0.25-0.5 % solution. Results . We found out that combination of procaine with non-steroidal anti-inflammatory medicines and gastric secretion blockers have an effective analgesic effect. Treatment of pain by intravenous injection of a solution of novocaine and its combination with anticholinergic and myotrop antispasmodics was ineffective.