OWN AND PARENTAL PREDICTORS OF TOBACCO SMOKING IN CHILDREN OF PERSONS WITH EARLY ISCHEMIC HEART DISEASE
Aim. To identify predictors of tobacco smoking (TS) in persons with parental history of early (onset: ≤55 years old - men, ≤60 years old - women) coronary artery disease (CAD). Material and methods. We examined 265 families: probands (n=250; 76,4%) with previous myocardial infarction (MI), their spouses (n=173; 82,4% women) and biological children of probands (n=326; 53,1% men) aged 14-38 years. In children of probands aged 14-22 years, spouse of proband was the mother in 83% of cases, aged 23-38 years - in 71%. In further analysis, occasional and daily smoking groups was combined in TS group. Predictors of TS were selected by logistical regression in 2 groups, taking into account the median age of the children. Results. Forty four out of 154 children of probands aged 14-22 years noted TS. TS was associated with own age (odds ratio (OR): 1,27, 95% confidence interval (CI): 1,10-1,46; р=0,001) and male sex (OR: 2,61, 95% CI: 1,17-5,84 (р=0,020). Independent predictors of TS were own alcohol consumption (OR: 5,77, 95% CI: 1,82-18,3; р=0,003) and low-density lipoprotein cholesterol (OR of upper tertile >3,16 vs 2 lower tertiles, ≤3,16 mmol/L: 0,16; 95% CI: 0,06-0,45 (p=0,001)). Smoking of spouse-parent was also significant (smoker vs non-smoker: OR: 10,6; 95% CI: 3,28-34,4 (p=0,000). Eighty four out of 154 children of probands aged 14-22 years noted TS. TS was independently associated with a lower own (OR: 3,19; 95% CI: 1,92-5,32 (p=0,000) and parental education (for probands: OR: 1,54; 95% CI: 1,06-2,24 (p=0,025); for spouses: OR: 1,77; 95% CI: 1,06-2,96 (p=0,030)). Conclusion. In the children of probands 14-22 years old, the only independent parental predictor of TS was the smoking of their parent-spouse, which reflects the dominance of maternal transmission at this age. In older children of the probands, TS was independently associated only with a lower level of their own and parental education.