The effectiveness of immunoprophylaxis of pertussis with combined vaccines containing whole cell or acellular pertussis vaccine
The present article provides the materials on the effectiveness of immunoprophylaxis of pertussis with combined vaccines containing whole cell or acellular pertussis vaccines. It is shown that a whole cell pertussis vaccine is more effective than an acellular pertussis vaccine, which is stipulated mainly by the type of immune response against the administration of a prophylactic drug. Numerous studies have found no association between vaccination with vaccines containing whole cell pertussis vaccine and CNS pathology, sudden death syndrome. It is noted that vaccines containing whole cell pertussis vaccine manufactured in various countries differ in the method of manufacture, the content of individual antigens and their qualitative characteristics. It considerably determines the differences in reactogenicity and efficacy of vaccination.