KISSPEPTIN EFFECT ON PHAGOCYTE ENZYMATIC ACTIVITY
Recently discovered hormone kisspeptin (KP) plays an essential role in human reproduction and possesses specific receptors on different types of immunocompetent cells. However, literature data on KP immunomodulating action are lacking. The aim of this work was the assessment of KP effect on the activity of myeloperoxidase (MPO) both secretory [MPO] <sub>ex</sub> and intracellular [MPO] <sub>i</sub>, as well as monocyte indolamin-2,3-dioxygenase (IDO) in women. It was demonstrated that KP in concentration corresponding to II trimester lowered the activity of [MPO] <sub>i</sub> monocytes and elevated the [MPO] <sub>ex</sub> activity. KP in concentration corresponding to II trimester improved the IDO activity that favored the maintaining of immunological tolerance in pregnancy and successful fetal development.