THE ROLE OF CYTOKINES IN THE PATHOGENESIS OF COMPLICATIONS IN BURN DISEASE
The levels of tumor necrosis factor (α-TNF), interleukin-Iβ (IL-Iβ), interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) in the urine of patients with burn disease were investigated. The objects of study were men with burns of the skin IIIB-IV severity, among which the first group was affected with a favorable outcome, and the second death. The aim of the research was to study the dynamics of cytokine concentrations in the urine of patients with different outcomes of burn disease. Found that the reduction of α-TNF and increased of IL-10 may indicate a pathogenic role of these cytokines in the development of life-threatening complications in this pathology. Determination of α-TNF and IL-10 in the urine should be included in the diagnostic algorithm of patients with severe burns for predicting the course of burn disease.