Development of the production technology of soft medicinal form with katiazinum for the correction of spermatogenesis disturbances
This article reflects the results of the study of structural and mechanical properties and the dispersity of the oil phase of the developed soft drug with katiazinum for the stimulation of spermatogenesis. The ointment of «oil/water» emulsion type proved to have thermal and colloidal stability. The particles of oil phase are predominantly from 3 to 4 microns in diameter. The rheological properties of the presented emulsion system have also been studied in the temperature range from 10 to 50°C, this corresponding to the possible bounds of use and storage, and at shear rates in the range from 1,002 to 150,000 s-1. According to the plotted curves the dynamic viscosity decreases with increasing temperature up to 30°C, that can testify to the reduction of efforts on the application of the ready-made preparation to the skin the temperature of which is 34°C. It has also been shown that the effective concentration of the active substance makes up 0,5%. The technology to produce soft medicinal form with katiazinum has been developed. The technological scheme of the production of this ointment with katiazinum according to GMP requirements has been devised.