Treatments results of pediatric patients with Ewing’s sarcoma family tumors in Belarus Republic
Ewing Sarcoma (ES) included classical ES of bone and extraskeletal ES based on genetic breakdowns of 22 chromosomes. Aim of this study was to evaluate the long-term survival and to investigate whether patient characteristics differ between cases with favorable and unfavorable clinical outcomes.161 pediatric patients with ES were analyzed. Survival rate estimated via the Kaplan - Meier method and compared using log-rank tests and Cox proportional hazard models.15-year overall survival (OS) of all patients was 65.9%, for the cohorts of patients with localized and metastatic disease OS was 70.1% and 21.9% respectively. Known clinical prognostic factors (age, sex, tumors volume, response to treatment and other) did not differ between patients with favorable and unfavorable outcomes. Treatment results for patients with ES family tumors from the Belarus Republic comply with generally accepted standards. Patients with metastatic status need new treatment strategies. Searching for new predictive markers is necessary for early detection of resistant to conventional treatment patients with localized ES.