SUBCHRONICAL IMPACT OF SUCCINATE-CARRYING COMPOUNDS ON METABOLISM OF LIPIDS, NITROGEN OXIDE AND PROCESSES OF LIPIDS PEROXIDATION IN RATS ORGANISM
Aim of our study was to investigate the peculiar impact of succinate-carrying compounds on the state of lipid peroxidation, NO and lipids metabolism in rats organism. We examined an anti-diabetic medicine Phensuccinal (PhS) and metabolites of its 1st phase biotransformation - 2-hydroxyphenylsuccinamide (2-HPhSA) and ß-phenilethylsuccinamide (ß-PhESA). We found that PhS in an effective dose (25 mg/kg of b.w.) and its metabolites in equimolar doses showed the hypolipidemic and antioxidant activeness. In sub-toxic doses PhS and 2-HPhSA proved to cause dislipidemia; beside that, PhS and both of its metabolites stimulated processes of lipid peroxidation, amongst other by decreasing the NO-synthase chain of NO metabolism activeness. When injected in small doses, all three compounds brought to NO-NOS system the changes exclusively that exclusively enhanced its adaptability and stroke a balance between the free radical oxidation and antioxidant protection. We concluded that PhS metabolites could vary by their influence on its biological effects.