Regulation of the Oxidative Processes in Organs of Mice under Action of the Chemical and Physical Factors at Low Doses
Influence of the separate and combined action of the lead nitrate at the wild range of doses, uranyl nitrate and the chronic γ-irradiation at the low dose on the development of the oxidative stress in organ of mice CBA (males) and morphophysiological state of thyroid gland was studied at the early and remote periods after action. Complex and significant different character of changes of parameters of the oxidation process regulation in liver of mace (males) and the morphological parameters in its thyroid gland is revealed. The scale and direction of these changes depend on the age of animals, the nature of toxicants and their concentrations, and also period after actions. Analysis of literature and the data obtained allow us to make it a conclusion that the development of consequences for animals living under unfavorable ecological conditions may not predict using the extrapolation of data which were obtained at large doses to sphere of low doses.