Chronic alcoholic pancreatitis: several pathogenic mechanisms of intestinal digestion disorder
Serious clinical problem in most patients with alcoholic chronic pancreatitis are disorders of intestinal digestion, the pathogenetic mechanisms that are not fully understood. The Aim. Examine the state of intestinal digestion in patients with chronic alcoholic pancreatitis. Materials and methods. The state of the intestinal hydrolysis was studied in 37 patients with alcoholic chronic pancreatitis based on studies amylolytic activity of small intestinal mucosa, enzyme activity of the membrane phase of intestinal digestion, the regulatory function of intestinal enzymes and protein content in the mucosa of the small intestine. In 30 patients studied ultrastructure of intestinal epithelium. Results and discussion. In patients with alcoholic chronic pancreatitis violation observed recessed and membrane stages of intestinal digestion. Last combined with low protein Security mucosa of the small intestine, the weakening of the regulatory function of intestinal enzymes and defeat elements brush border. Conclusion. The development and progression of symptoms of exocrine pancreatic insufficiency in patients with alcoholic pancreatitis is caused by a violation of the intracavitary and membrane stages of intestinal digestion.