CORRECTION OF IMMUNOMETABOLIC DISTURBANCES AT THE DONTOGENOUS OSTEOMYELITIS OF MAXILLOFACIAL AREA
In a blood plasma, more in washout from a residual cavity after opening of osteophlegmon of a mandible at patients with a dontogenous osteomyelitis of maxillofacial area rising of concentration of proinflammatory cytokines (TNFα, IL-1α, IL-6, IL-8, IL-18), IL-2, IFα, activation of system of a complement, an intensification of processes of peroxidation of lipids, an imbalance of antiinflammatory cytokines and regulators of system of a complement at systemic level, local rising IL-4, IL-10, depression of level C1-ingibitor, a factor of H and activity of antioxidatic enzymes is revealed. Standard treatment not correction disturbances of the majority of the studied immunometabolic indicators both on systemic and at local level. Additional application of combinations of immunomodulators and membranoprotektor, unlike standard treatment, is more effective correction the general and local immunometabolic disturbances, settling down on ascending of degree of efficiency in following sequence: standard treatment → «Gepon» + «Fosfogliv» → «Polioksidony» + «Fosfogliv Forte» → «Longidaza» + «Fosfogliv Forte».