IMMUNOSUPRESSIVE THERAPY AND RENAL SURVIVAL IN MESANGIPROLIFERATIVE GLOMERULONEPHRITIS WITH PROTEINURIA/HEMATURIA
Aim. To assess the reasonability of immunosuppressive therapy with cyclophposphamide of mesangioproliferative glomerulonephritis with proteinuria/haematuria. Methods. 112 patients with mesangioproliferative glomerulonephritis with proteinuria/haematuria (mean age 25,0±8,2 years, mean duration of kidney disease - 11,3±5,3 years) were included into the study. 23 patients received immunosuppressive therapy: 2 - monotherapy with corticosteroids, 6 - monotherapy with cyclophosphamide, 15 - combination of corticosteroids and cyclophosphamide. Results. In 21 patients immunosuppressive therapy with corticosteroids and cyclophosphamide improved renal survival in presence of glomerulonephritis activity: proteinuria ≥0,5 g/l, haematuria ≥50 erythrocytes in vision view, elevation of seromucoid level ≥0,210 units, hyperfibrinogenemis ≥4,0 g/l, histological activity index ≥21 and/or total sclerosis index ≥8. Conclusion. Immunosupressive therapy can be indicated in patients with mesangioproliferative glomerulonephritis in presence of signs of glomerulonephritis activity.