Studies of specific activity and safety of medical-prophylactic bacteriophage preparation against Acinetobacter baumannii and Pseudomonas aeruginosa
We сonducted preclinical studies of the bacteriophage preparation antibacterial activity of the preparation is aimed at representatives of the non-fermenting Gram-negative bacteria Acinetobacter baumannii and Pseudomonas aeruginosa. We studied the specific activity of the preparation on the bacterial strains of microorganisms belonging to different species; preparation safety was studied in animals experiments to evaluate acute and chronic toxicity. Developed preparation lysed only homologous microbial species. In laboratory conditions, it did not result to the death of male and female mice and rats at a single and repeated oral and intra-abdominal injection. The content of formed elements in the blood of experimental animals was within the physiological norm. Pathological changes in the body is not found. The preparation is recommended for conducting clinical trials.