DEVELOPMENT OF ENDOGENOUS INTOXICATION ON THE BACKGROUND OF EXPERIMENTAL OBESITY MODELING
According to WHO, the steady increase in the frequency and prevalence of alimentary obesity among the world’s population allows speaking of a pandemic of this pathology, while so far only 5.0-7.0% of cases are able to identify its causes. Accordingly, the pathogenetic features of both development and its impact on the functional state of the body are insufficiently studied and require clarification. At the same time, the most complete information about the impact of alimentary obesity on the development of various pathological processes, including endotoxicosis, can be obtained only when conducting diverse experimental studies..Experimental studies were carried out on 10 female rabbits on the characteristics ofendogenous intoxication on the background of modeling experimental nutritional obesity. The criterion for the analysis was the dynamics of the indicators of antioxidant activity, lipid peroxidation and the content of medium-weight molecules in the blood against the background of experimental alimentary obesity modeling, compared with the indicators before the experiment. Experimental studies were carried out in accordance with the "Rules for conducting studies using experimental animals" of the Ministry of Health RF. Modeling of obesity was performed under conditions of stimulation of appetite and physical inactivity in experimental animals. To stimulate increased appetite 10 minutes before feeding, an intramuscular injection of insulin was performed at the rate of 0.05 U per 1 kg of animal body weight. In this case, feeding was carried out 6 times a day, in equal portions based on the consumption of the total daily amount of balanced feed. After that, the animals were additionally fed without restriction with a feed high in vegetable fats against the background of stimulation of appetite, which was ensured by an injection of insulin before each meal. Modeling obesity using this technique provided an increase in animal weight by more than 25% for 1.0-1,5 months. A comparative analysis of the dynamics of lipid peroxidation, antioxidant activity, and medium-weight molecules showed that, against the background of peripheral hypoxia, there is a transition to anaerobic catabolism, which leads to a decrease in antioxidant activity. The data obtained indicated the development of endogenous intoxication on the background of EAO modeling, which was associated with an increase in peripheral hypoxia. Against this background, a decrease in antioxidant activity is noted and the prerequisites for a partial transition to anaerobic catabolism are created. Accordingly, peripheral hypoxia and a decrease in antioxidant activity led to the formation of toxic products of lipid and protein metabolism. At the same time, the development and progression of endogenous intoxication due to metabolic disorders is noted against the background of modeling experimental alimentary obesity.