Allogeneic hematopoietic stem cell transplantation in children: now, problems and prospects
Hematopoietic stem cells transplantation (HSCT) is a potentially curative method for patients suffering from different oncological, hemato- logical and inherited diseases. Two variants of these procedures are autologous (аuto-HSCT) and allogeneic (аllо-HSCT) transplantation. Indications, availability of donor (related, unrelated, haploidentical), conditioning regimen (myeloablative, reduce intensity conditioning regimens, non-myeloablative), methods of “graft versus host disease” prophylaxis are taken into account when performing HSCT. In allo- HSCT “graft versus leukemia” effect develops and it is the platform for providing of immunoadoptive therapy.