IMMUNO-ENDOCRINE DISORDERS IN GIRLS OF PUBERTAL AGE WITH CHRONIC INFECTIOUS-INFLAMMATORY DISEASES OF THE UROGENITAL AREA
Were examined 50 pubertal girls age with chronic infectious-inflammatory diseases of the urogenital area in the stage of remission. We determined the content of IL1β, IL-4, IL-6, IL-8, IL-10, IFN-γ, G-GSF, progesterone and estradiol in the blood serum. Demonstrated that remission of the disease is characterized by a significant increase in concentrations of proinflammatory cytokines IL-6, IL-8, as well as inducers of activation of the immune response (IL-4 and IFN-γ), which is accompanied which is accompanied inhibition of synthesis of progesterone and estradiol. Despite the absence of clinical manifestations of disease in pubertal girls age with at chronic infectious-inflammatory diseases of the urogenital sphere in remission tested activity immunoinflammatory process and violation of the synthesis of sex hormones. Detected changes predispose to the emergence of reproductive disorders.