IMPAIRED FLOW-DEPENDENT VASODILATATION IN THE SYSTEMIC CIRCULATION ARTERIES AND POSSIBILITIES FOR ITS CORRECTION IN PATIENTS WITH DIFFERENT STAGES OF CHRONIC HEART FAILURE
Objective: to assess endothelial function using computed sphygmography in patients with chronic heart failure and evaluate possibilities for its correction with perindopril A during the acute drug test. Materials and methods. We examined 48 patients with chronic heart failure (CHF) after myocardial infarction. Patients were divided into 2 groups: group 1 included individuals with stage I CHF; group 2 comprised individuals with stage IIa CHF. All study participants underwent computed sphygmography prior to and 6 hours post perindopril arginine (perindopril A) intake. Computed sphygmography was used to evaluate the changes in the average speed and acceleration of the radial artery wall movement during the inflow and outflow phases upon reactive hyperemia. Results. Patients in both groups were found to have impaired endothelial vasomotor function. Changes were more pronounced in the group 2, where patients were characterized by reduced indicators reflecting biomechanics. Perindopril arginine ensured the improvement in the arterial wall reactivity, which was more significant in patients from group 2. Conclusion. Patients with CHF demonstrated progressive deterioration of endothelial function, which correlates with the severity of CHF. Perindopril arginine has a positive effect on the endothelial vasodilatory function after a single intake; this effect depends on the severity of the endothelial vasodilatory function impairment.