HISTOLOGIC PICTURE OF STOMATITIS IN EXPERIMENT ON RATS
The aim of the study was to characterize the histological picture of stomatitis in an experiment on white rats and to evaluate the effectiveness of using highly active cultures of lactobacilli for its treatment. The experiment was carried out on 32 females of nonbreeding white rats weighing 230 g in two stages, including two-fold treatment of the oral cavity of rats with 9% acetic acid (AC) for 3 days and application of the Staphylococcus aureus culture on the 4th day of the experiment. The rats were divided into 5 series (8 in the control series and 6 in the experimental series) for the further treatment of stomatitis with highly active Lactobacillus strains. Biopsy of the gingiva mucous membrane was sampled on the 1, 3, 5, 6, 9 and 12 day of the experiment for histological examination micropreparations according to a standard procedure. After using AC on the oral cavity it was found the macro and microscopic signs of inflammation which intensified after exposure of Staphylococcus aureus. The histological picture of the oral mucosa approached to intact by the 5th day of treatment with lactobacilli, while in the control group only by 12 day of the experiment and not in all animals. The results of our studies have shown the effectiveness of the use the highly active cultures of lactobacilli for the treatment of oral diseases, including bacterial stomatitis.