Risk factors and pathogenesis of isolated systolic hypertension in the young: modern points of view
Isolated systolic hypertension in the young (ISHY) is more common among men, or among obese people, or among athletes and active population groups, which determines its heterogeneity. The close interlacement of neurohumoral and metabolic factors forms a stable background for hypertension. In some cases, ISHY is associated with uneven increase of arterial stiffening with age. However, the absent «interlacement» of factors in the presence of increased stroke volume and hyperkinetic circulation is potentially dangerous in terms of hemodynamic transition and the formation of blood pressure trajectories, leading in the future to established hypertension and cardiovascular complications. The review systematizes the recent literature data on risk factors and pathogenesis of ISHY.