Correlative links between disorders of redox homeostasis and disorders of the hepatorenal system in cats with chronic renal failure of the third stage according to IRIS
The nature of functional disorders of the hepatorenal system in chronic renal failure is determined by the duration of the pathological process, which is associated with the degree of lipid peroxidation resulting from an imbalance between oxidants and antioxidants, which leads to a violation of redox signaling and damage to hepatocyte macromolecules. The results of biochemical studies of the blood serum of sick animals obtained by us testified to the development of oxidative stress against the background of a chronic process in the urogenital tract and the involvement of components of the hepatorenal system in the pathological process. Direct correlations were found between the level of redox homeostasis and the degree of disorders of the hepatorenal system in cats with chronic renal failure of the third stage according to IRIS: ALT - 81.26 ± 6.71 U/l and 86.03 ± 4.29 U/l; T-Pro - 91.80 ± 3.90 g/l and 94.03 ± 3.05 g/l; ALB - 27.45 ± 1.40 g/l and 26.43 ± 2.03 g/l; GLB - 64.35 ± 2.10 g/l and 67.60 ± 2.56 g/l; A/G - 0.42 ± 0.03 and 0.39 ± 0.02; SDMA - 30.19 ± 5.10 ug/dL and 33.60 ± 4.93 ug/dL; UREA - 39.19 ± 3.12 µmol/l and 40.97 ± 2.85 µmol/l; CREA - 432.23 ± 11.50 μmol/l and 437.96 ± 13.16 μmol/l.