THE EFFECT OF HODGKIN'S LYMPHOMA ON A WOMAN'S REPRODUCTIVE PO-TENTIAL
In the modern world, there is a significant increase in cancer incidence. One of the pathological conditions most common among women of reproductive age is Hodgkin's lymphoma. At the age of 14, this disease observed in 6% of cases, in adolescence this indicator comes out on top and is 35%. Hodgkin's lymphoma is a malignant lymphoproliferative disease, the morphological basis of which are derivatives of B-lymphocytes of the germinative centers of the lymphoid follicle - Reed-Berezovsky-Sternberg cells and single-core Hodgkin cells and characterized by an aggressive course and good sensitivity to antitumor therapy. Chemotherapy and radiation therapy leads to complete remission in 85-90% of cases, which brings to the fore the problem of long-term consequences of therapy associated with reproductive disorders. The article discusses the mechanisms of development of premature ovarian insufficiency and menstrual function disorders caused by the use of chemotherapeutic drugs, the consequences of radiation therapy of lymph nodes located below the diaphragm. Special attention paid to the tactics of pregnancy management in women with newly diagnosed Hodgkin's lymphoma or with its recurrence. The main indications for termination of pregnancy are reflect.