Clinical observations of epileptic encephalopathy induced by fever in children of school age
Purpose. Present two clinical cases of fever-induced epileptic encephalopathy in school-age children (FIRES). Materials and methods. Two clinical cases of FIRES syndrome recorded in the Tyumen region were analyzed. The data are obtained from case histories and discharge reports of the children’s neuropsychiatric department of the Regional Clinical Hospital No. 2 and the Regional Clinical Hospital No. 1 of Tyumen. Results. The descriptions demonstrate the dramatic course of this syndrome with prolonged malignant hyperthermia and superrefractory epileptic status. However, in the first case, an outcome in a vegetative state is observed, and in the second, a moderate neurological and cognitive deficit. Conclusion. The clinical observations presented by us, as well as the literature data demonstrate the need for further study of the methods for stopping epileptic status in FIRES syndrome, evaluating the effectiveness of the ketogenic diet and immunotherapy (steroids, immunoglobulins. It is necessary to determine the effectiveness of various groups of antiepileptic drugs in FIRES in both acute and chronic phases This is especially important from the standpoint that FIRES develops in previously healthy children, leading to serious disability in a short time.