THE INFLUENCE OF SEX STEROIDS ON BEHAVIOR OF RATS WITH GENETICALLY DETERMINED DIFFERENCES IN EXPRESSION OF ISOFORMS OF THE D2 RECEPTOR
The aim of this work was a comparative analysis of locomotor activity at different stages of the estrous cycle of the two subpopulations of WAG/Rij rats with genetically determined differences in the expression of the isoforms of the D2 receptor. The research was conducted on two groups of mature rats with the genotypes A1/A1 and A2/A2 on the locus Taq 1A DRD2. Locomotor activity of rats (total amount 20, 10 with genotype А1А1 and 10 – A2A2) studied in the "open field" system according to the standard methods. Estrus phases identified through a vaginal smear. The results showed that a high plasma level of estradiol on stages of proestrus and estrus increases locomotor activity in rats with a genetically determined reduced expression of the short isoforms (genotype А1А1 on the locus Taq 1 A DRD2). In rats with the genotype A2A2 at locus Taq 1 A DRD2 there were no changes in levels of sex steroids in the blood plasma in the dynamics of the estrous cycle.