FEATURES OF IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
Objective: To determine the priority of the immune response in psoriasis and psoriatic arthritis and reveal the markers of prognostic significance. Materials and methods. The study included 97 patients with progressive psoriasis vulgaris. Divided into 3 groups: 1 – psoriasis (n = 49), 2 – psoriatic arthritis (n = 48), 3 – apparently healthy blood donors (n = 45), matched for age and sex. Cell-mediated immunity was assessed by indirect immunofluorescence using monoclonal antibodies to CD3, CD4, CD8, CD16, CD19. Phagocytosis activity was assessed by absorbing ability of neutrophils against particles of melamine-formaldehyde latex. The concentration of IgA, IgM, IgG in the serum was determined by the enzyme-linked immunosorbent assay. Results and conclusions. Immunological psoriasis markers identified: hyperactivation of the innate and adaptive cellular immunity, humoral immunity deficiency, deviation of cytokine profile towards Th2 type. Markers of psoriatic arthritis formation: high levels of TNF-α and IFN-γ in the serum of patients with psoriasis.