EFFICACY OF COMBINATION TREATMENT WITH ANTI-IGE PLUS SPECIFIC IMMUNOTHERAPY IN PATIENTS WITH ATOPIC DISEASES
ALLERGEN-SPECIFIC IMMUNOTHERAPY (ASIT) IS A VERY EFFECTIVE TECHNIQUE IN TREATMENT OF MANY ALLERGIC DISEASES. IT GREATLY IMPROVES THE QUALITY OF LIFE. THERE'S A RISK OF ADVERSE SYSTEM REACTIONS AT THE TIME OF ASIT. TREATMENT WITH ANTI-lgE ANTIBODIES (OMALIZUMAB, XOLAIR) ALLOWS DECREASING THE CIRCULATING IgE LEVEL AND LESSENING AN EXPRESSION OF HIGH-AFFINITY FceRl RECEPTORS ON THE SURFACE OF BASOPHILES AND MAST CELLS, INHIBITION OF EARLY AND LATE PHASE OF ALLERGIC INFLAMMATORY RESPONSE. COMBINATION OF ANTI-lgE THERAPY AND ASIT CAN LEAD TO DECREASE OF RISK OF ADVERSE SYSTEM REACTIONS.