MUCOCILIARY clearance disturbances IN bronchial asthma
The complex estimation of mucociliary system functioning have been conducted in 92 patients with bronchial asthma. It included the study of integral rate of bronchial mucociliary clearance by dynamic perfusion lung scanning, registration of ciliated epithelium cilia motion activity in bronchi biopsy material, and the study of viscous elastic properties of bronchi secretion. 85% of the patients had mucociliary insufficiency, the intensity of which was in the direct proportion to the disease severity. The forming of mucociliary insufficiency was caused by the active inflammatory process in bronchi, the disturbance of bronchi mucosa structure, the rise of bronchi secretion viscosity and the drop of bronchi ciliated epithelium cilia beat frequency. The study of correlation between these parameters and bronchial mucociliary clearance enabled us to offer the method of mucociliary insufficiency diagnostics.