T-helper Activity at Women Nadym of YaNAO
Immunological reactions of human in unfavorable conditions of the North are characterized by a short period of resistance and formation of specific immunoglobulins, deficiency of the whole T-cell population, a decrease in the reserve potential of immune homeostasis, and an increase in the frequency of immune imbalances. Aim of study. determination the content of helper lymphocytes in peripheral blood in women aged 40-60 living in the city of Nadym of the Yamalo-Nenets Autonomous District and assess their receptor activity. Materials and Methods. The analysis of the results of a survey of 30 women living in the town of Nadym Yamalo-Nenets Autonomous District in age from 40 to 60 years. Immunological examination of people included determination of the total number of leukocytes, study of hemograms, determination of peripheral blood lymphocytes with CD3+, CD4+ receptors. Results and discussion. Depletion of cellular immune reserve was found in the women of Nadym city, aged 40-60 years, living in unfavorable climatic and ecological conditions of the northern regions, that promotes the development of secondary ecologically dependent immunodeficiencies: 96.66% of surveyed suffer from a lack of receptor (CD3+), which forms and transmits a signal activation in the cytoplasm of T-lymphocytes; In 30,00% of surveyed women there were deficiency of T-lymphocyte with (CD4+) receptor, which play a major role in determining the way of the immune response. The revealed deficiency of lymphoid populations CD3+ and CD4+ is correlatively interconnected with the concentrations of monocytes, neutrophils and eosinophils. Conclusions. In 40-60 year old women, an elevated monocyte count is recorded in 36.66% of cases; in 26,66% the increased content of eosinophils. Lymphocytosis occurs in 13.33% of cases. The most common defect in immune defense is a deficit of CD3 cells (96.66%) and CD4 deficiency (30.00%). The moderate correlations between the fluctuations in monocyte content, eosinophils and significant deficit of CD3-CD4 cells (r=0.40-0.50), as well as their high specific gravity, indirectly indicate a possible compensation of the T-cell reserve by leukocyte-number cells.