Impact of genetic polymorphisms in the renin-angiotensin-aldosterone system on the expression of clinical signs of hypertrophic cardiomyopathy
Genetic polymorphisms in the renin-angiotensin-aldosterone system and clinical signs of hypertrophic cardiomyopathy in patients with this pathology were investigated. The influence of <i>ACE</i> gene <i>I/D</i>-polymorphism, <i>CMA1</i> gene <i>-1903A>G</i> polymorphism and <i>AGTR1</i> gene<i> 1166A>C</i> polymorphism on the severity of left ventricular hypertrophy was found, association <i>II</i> genotype of <i>ACE</i> gene and <i>CT</i> genotype of <i>CYP11B2</i> gene with a greater severity of ischemic changes, and association <i>DD</i> genotype of <i>ACE</i> gene with increased QT dispersion was identified.