Pathophysiological mechanisms of development of bronchial asthma with participation of C-786T polymorphic variants of NOS3 gene
The C-786T association (rs2070744) of gene polymorphism of nitric oxide synthase NOS3 controlling products of the NO intracellular messenger is analyzed in a pilot research according to the informed consent of patients of pulmonary department of the Adyghe Republican Clinical Hospital with the severe forms of bronchial asthma diagnosed according to GINA criteria (2011). Despite participation of NOS3 in pathophysiological processes and reliable association C-786T of NOS3 gene, with such clinical manifestations of bronchial asthma as hypostasis and a bronchospasm in many regions of the world, statistically significant relationship of C-786T of NOS3 gene with the mixed disease forms is not confirmed at inhabitants of the Republic of Adyghea.