The state of serotonin transport system in patients with genital endometriosis
Purpose: to investigate status of serotonin transport system (on the concentration of serotonin in the serum of venous blood) women with genital endometriosis, reflecting the state of serotonergic neuromediation, which determines the character of psychovegetative and nociceptive manifestations of the disease. Materials and methods: The study was included 71 woman of reproductive age with different forms and clinical manifestations of genital endometriosis (average age 34,97 ±0,7). The comparison group consisted of 30 women of reproductive age (average age of 30.9±1,13 In addition to routine clinical and echographic studies, the survey of the psychological status was carried out using a number of techniques: depression selfassessment questionnaire A.Beck, hospital rating scale of anxiety and depression, questionnaire Spielberger Hanin, the questionnaire Mini-mult, quality of life questionnaire SF-36, «The Questionnaire for the detection of signs of vegetative changes» and «The schema of the study to detect signs of vegetative disorders». To quantify serotonin in the blood serum is applied immunoassay test Serotonin Elisa, Labor Diagnostika Nord GmbH&KG. Main results and conclusions. The presence of disturbing-depressive symptoms is the core of the clinical semiotics women with genital endometriosis, even in cases of asymptomatic. This significantly reduces the indicators of the quality of life of patients, mostly at the expense of the mental health component. Humoral serotonin transport system of women with genital endometriosis is characterized by objectively reduced in terms of serum serotonin. The level of serotonin blood serum of patients with genital endometriosis correlated with the severity of pain syndrome in the absence of decisive importance is the presence of disturbing-depressive symptoms.