State of renal transport nitrite and nitrate due to combined use rats thyroxine and captopril
Work on mongrel male rats with MT 180-200 g. Thyroxine (T4) produced by the "Berlin Chemie" (Germany), the animals were injected intragastrally in the 1 % starch gel at 50 mg per 100 g bw. Time 1 hour or 24 hours prior to the kidney function test, as well as 50 mg per 100 g bw a day for 7 days. Single dose of T4, captopril was administered in the drinking water (20mg/l) for 24 h before a single dose of T4 or within 24 hours of the appointment of T4. The rats treated with T4 for 7 days. Captopril was administered for the duration of the experiment. The kidneys of animals were studied based on 5 % water load. Found that in all the experimental groups, the introduction of T4 resulted in increased renal excretion of endogenous nitrate - the end products of oxidation of NO. Then, as the combined administration of T4 + captopril helped to reduce nitrate levels in plasma and the rate of excretion by the kidneys. The administration of captopril has a beneficial effect on the activity of the kidneys of rats treated with T4, increasing the value of the glomerular filtration rate, reduce the renal excretion of nitrate, preventing retention nitrite in plasma.