Current methods of anticancer therapy and immune system
In recent years, significant clinical success in the treatment of cancer has been achieved by immune checkpoint therapy, as well as chimeric antigenic receptors (CAR-t-cells).Inhibitory receptors of T-cells (CTLA-4 and PD-1) interact with their ligands and suppress the activity of T-cells-effectors, which is one of the mechanisms of tumor escape from immune surveillance. This report contains a brief description of current methods of immunotherapy: vaccine, CAR-T-cell therapy and blockade of immune checkpoints.The results of our own research on the relationship between the immune system and its response to treatment with the effectiveness of vaccine therapy and anti-CTLA-4 therapy by nivolumab are presented.