Microtubular Disrupter Nocodazole and Vesicular Transport Inhibitor Brefeldin A Attenuate the Glutoxim Effect on Na+ Transport in Frog Skin
Using the voltage-damp tednique, a possible role of miCTotubules and vesioalar transport in the effert of pharmacological analogue of oxidized glutathione, drug glutoxim, on Na+ transport in the frog Rana temporaria skin was investigated. It was shown for the first time that the disrupter of miCTotubules noradazole or inhibitor of vesicular transport brefeldin A similarly modulate (rampletely inhibit) the stimulatory effert of glutoxim on Na+ transport. The data suggest the involvement of reorganization of miCTotubules and veskular transport in the regulatory effert of glutoxim on Na+ transport.