Biomarkers In The Diagnosis Of Acute Kidney Injury. Communication I
In the past few years increasing attention attended to the possibility of using biomarkers in the diagnosis of acute kidney injury because of disadvantages of the traditional parameters such as serum creatinine and urea, diuresis measurement, which on the one hand depends on a number of extrarenal factors, on the other - they change occurs in the later, irreversible stages of renal tissue damage. This article analyzes the possibility of using a number of markers in the early diagnosis of different types of AKI. First part of work discusses the concept of biomarker, approaches to classification, as well as proven according to experimental and clinical studies diagnostic value of the most studied biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule (KIM-1), interleukin- 18, the liver fatty acid binding protein (L-FABP), cystatin C, etc.