Albumin in intensive care of neurological and neurosurgical patients
Albumin is almost the only recommended colloidal solution now. Numerous multicenter studies that compare the safety and effectiveness of albumin and salt solutions did not give unambiguous results. There is also no consensus on the use of albumin solutions in patients with severe CNS lesions. In patients with acute severe brain damage on the background of a sharp increase of the level of catabolic hormones, pro-inflammatory cytokines, albumin of the plasma can sharply decrease during the first day of the disease and badly recover in dynamics. Introduction of human albumin to intensive care unit patients not only improves the colloid-oncotic properties of the plasma, but also the acid-base status of blood, improves its transportation and information potential, normalizes the pharmacokinetics of the administered drugs.