SYNTHESIS AND STRUCTURE-ACTIVITY CORRELATION STUDIES OF HYDROXY ISONIPECOTIC ACID DERIVATIVES <i>INVITRO </i>AND <i> IN SILICO</i>: MOLECULAR DOCKING MODEL DESIGN FOR DRUG DISCOVERY
Correlation between biological activity (both in in vitro and in silico ) and structure of hydroxy isonipecotic acid derivatives has been studied. Based on comparative analysis of the results obtained the model for screening of polyhydroxy substituted acid derivatives as potential TB pharmaceutical drugs has been proposed.