Transdiagnostic biomarkers in the evaluation of suicidal predisposition in drug addicts
Objective: to substantiate the possibility of non-invasive instrument assessment of suicidal pre-disposition based on heart rate variability in people with drug addiction. Materials and methods. In the narcological hospital, 321 patients were examined with ICD-X-verified second stage of addiction (F11.хх2). The total number of patients who noted narcotic overdose was 36.5%. The division into control / main groups was carried out using the Beck questionnaire. The first (l) - control group consisted of patients without manifestations of auto-aggressiveness (n = 99 people, including 85 men and 14 women), at the age of 27.3 / 27.4. The second (2) group - comparisons - included 222 patients with auto-aggressive manifestations (men - 148, women - 74. Age: 27.3 / 25.8). The total score at the time of treatment on the Beck scale in the first group was 10.5, in the second it was 24.4 points (P <0.0l), which indicates moderate depression among the patients of group 2. The total points for the autoaggression subscript we entered in the control group was l.2 and in the main it was 6.9 points. The third (3) reference group was made up of healthy individuals (n=32) at the age of 24.0±1.8. Results: the vascular component of adaptation prevailed in the first group, with the LF index of 42% (l) / 34% (2) / 24% (3) (P<0.05). The second group was dominated by the neuro-endogenous component, where there was such a distribution of the VLF index: 27% / 55% / 16% (P <0.00l). The high-frequency -HF, (respiratory) component was the most significant in the structure of HRV among the group of healthy individuals (homeostatic state): 31% / 11% / 60% (P<0.00l). The index of total HRV power on the TF index in individuals with auto-aggressiveness exceeded this parameter in control patients l.78 times and was l.20 times higher than in healthy individuals. The diagnostic value of the spectral characteristics of HRV (VLF, LF, HF) in identifying the ideological component “suicidal thoughts” was SE = 42%; SP = 100%; prevalence = 75%. Conclusion. Trans diagnostic biomarker is heart rate variability, its spectral characteristics may be associated with auto-aggressive, suicidal predisposition in patients with addictive pathology.