THE CORRELATION ANALYSIS OF THE CONCENTRATION OF IODINE-CONTAINING THYROID HORMONES IN THE BLOOD, CARIES INTENSITY AND THE ACTIVITY OF LIPID PEROXIDATION IN THE SALIVA OF RATS
Objectives. To identify and assess the degree of correlation between the concentration of iodine-containing thyroid hormones in the blood and the activity of the carious process in the enamel and dentin, lipid peroxidation intensity and antioxidant activity in the saliva of rats under the conditions of cariogenic effects. Material and methods. Mercazolil was administered at the dose of 25 mg/kg during 30 days, then up to 60 days the half dose was given, L-thyroxine - in low doses (1,5-3,0 mg/kg during 28 days, then up to 60 days 1,5 mg/kg was given). As cariogenic factors we used the Stephen diet (during 60 days), crowding stress (40 rats kept in one cage during 1 month, 30 rats during the second month) and their combination. The expressiveness of the carious process was evaluated by the prevalence, frequency, severity and depth of the lesion. The level of iodine-containing thyroid hormones was investigated by means of enzyme immunoassay using special diagnostic kits. The activity of lipid peroxidation and antioxidant systems in the saliva was determined by chemiluminescent method. The correlation analysis of the obtained data was carried out using Statistica 10.0 program. Results. The resistance of the enamel and dentin to carious lesions depends on the serum concentration of iodine-containing thyroid hormones due to their influence on the intensity of lipid peroxidation in the saliva and its antioxidant activity.