A Case of Chronic Tick-Borne Encephalitis in Vaccinated Person
The case of chronic encephalitis in vaccinated resident of territory of endemic tick-borne encephalitis (TBE) territory, where are prevalent Siberian subtype TBE virus Twice vaccinated vaccine FSME-Immun, produced from European subtype TBE virus.Disease (meningo-encephalitic form of acute TBE) developed at 5 months after vaccination. IgM and IgG were detected in cerebrospinal fluid by ELISA test. Increase of IgM concentration and seroconversion of IgG (1:1600 to 1:12800) were detected in sera. 3 years later, chronic TBE was developed with constant tremor of hands. Development of convulsion-hyperkinetic syndrom, transgression of bioelectric brain activity were detected. Gliosis foci in basal structures of brain were discovered by magnetic-rezonans tomography. IgG with high avidity were found in serum without IgM and TBE virus antigen.