WET GRANULATION TECHNOLOGY IN INDUSTRIAL PHARMACY
This review discusses wet granulation technology, a process that helps particles of different materials bind to each other, thereby reducing the possibility of separation of materials in subsequent processing steps during their processing and increasing the likelihood of proper dosage uniformity in the dosage form. Granulation is a size-enlarging process in which individual particles of a powder, usually composed of several different components, are combined together to form a larger, structured particle in which the original particles may differ. Granulation makes it possible to change the properties of the solid granular material. Increasing the particle size reduces the potential hazard or harmful effects of the dust. The structure of the granules improves the flowability and compaction of the powder, and also helps to ensure the uniformity of the composition of the powder mass in the case of mixing materials. Wet granulation is a particle size coarsening process widely used in the manufacture of dosage forms. There are several reasons for wet granulation of pharmaceutical mixtures. An increase in particle size leads to an improvement in fluidity. The wet granulation process physically binds the mixed particles, thereby reducing the chance of separation of substances and causing possible dosing uniformity problems. Another reason for granulation is to reduce the possibility of separation of the pharmaceutical substance and/or excipients. Granulation technology always guarantees good flow properties and a uniform bulk density of the powder before compression, which is especially important in pharmaceutical development, and also reduces the risk of delamination by creating multi-component granules with a more uniform composition compared to a powder mixture.