ATYPICAL RHABDOMYOLISIS OF SINGLE-TOED UNGULATES: PATHOMORPHOLOGY OF CHANGES IN ORGANS AND TISSUES
Atypical rhabdomyolysis is an acute disease characterized by profound metabolic disorders, dystrophic changes and accumulation of lactic acid and other acids in muscles, paresis or paralysis and degenerative changes in the central nervous system, appearance in blood and urine of myoglobin and its degradation products (myogenic autointoxication). The disease has not been well studied. Studies were carried out at the department of morphology and examination of the Ural State Agrarian University according to the generally accepted methodology with subsequent staining of sections with hematoxylin and eosin. The material was obtained from a 7-year-old male zebra. Death of the animal was asphyxia due to paralysis of the swallowing muscles. The zebra had changes in all organs and systems, accompanied by macroscopic changes of organs and characterized by dystrophic processes, muscle tissue melting with sarcolemma preservation, muscle thickening. In the study of parenchymatous organs marked congestion, the development of granular fatty dystrophy, edema of the brain tissue. Changes in the development of myoglobinuria in horses and, in particular, in zebra are registered at all organs and systems. The most characteristic changes are the development of congestive edema and dystrophic processes in tissues, as well as dystrophic-degenerative changes in muscle tissue. Typical changes are also recorded in the parenchymatous organs of ungulates.