MECHANISMS OF RELAPSE INITIATION IN COURSE OF CHRONIC OBSTRUCTIVE PYELONEPHRITIS
Aim of research: evaluate modulating affect of adrenaline on platelets’ activation during remission and relapse of chronic obstructive pyelonephritis (COP). Blood of 18 patients at the time of admission to hospital was used for investigation. Platelets’ aggregation was performed at aggregometer Chrono-Log (USA) using subthreshold concentration of PAF, ADP, adrenaline, whose stimulation in control group did not exceed 10 % aggregation. During relapse of COP (8 patients), stimulating effect of adrenaline on platelets was somewhat higher than during remission, but still lower than in control ( p < 0.05). ADP induced an effect lower than during remission and in control group. Simultaneous action of ADP and adrenaline exceeded action of ADP alone ( p < 0.001). Nevertheless, during relapse of COP no significant differences in adrenaline action on ADP-stimulated platelets as compared to remission phase was observed ( p < 0.01). PAF induced platelets’ aggregation higher than in control and during remission ( p < 0.01). Synergism of action of adrenaline and PAF was most marked and exceeded that of control and remission phase group ( p < 0.001). Thus, during COP relapse, adrenaline potentiates PAF affect, while action of ADP on platelets decreases, as well as potentiating effect of adrenaline, which implies restriction of stimulatory effect of platelets on leukocytes.