DETERMINATION OF ACTIVITY OF ENZYMES IN UREA AS ADDITIONAL METHOD ON MONITORING ACUTE KIDNEY INJURY IN CHILDREN WITH SEPSIS
Objective - to study the level of activity enzymes secreted by renal tubules in kids with sepsis to determine the significance as an additional method of monitoring acute kidney injury. Material. 20 children with sepsis Methods. Clinical examination, routine methods of control homeostasis, potassium, creatinine, glomerular filtration rate, X-ray, determination of activity B-glucoronidase (B-GL), gamma-glutamil transferase (GGT), alkaline phosphatase (ALP). Result. It was found that the increase in urinary excretion of enzymes clearly connected with degree of reduction of output and duration of the period of oliguria in kids with sepsis. This connection is most clearly seen in the group of children during the first months of life. Decreased excretion of all measured enzymes and oliguria lasting more than 5 days was a poor as prognostic factor and indication transformation pre-renal for renal form renal insufficiency. Conclusion. The authors believe that method useful to objectify the severity of acute kidney injury as well as determine of level the nephron's damage.