Change of hematological parametres after osteointegration of titanium percutaneous implants of rabbits
The article presents results of a study of the parameters of the peripheral blood of rabbits after osteointegration of titanium percutaneous implants. The experiments were performed on 10 dinically healthy rabbits of Chinchilla breed aged from 6 to 10 months, with an average weight of 3.4 ± 0.2 kg. The control group (n = 30) consisted of animals aged from 6 to 10 months and weighing 3.2 ± 0.4 kg. Blood tests were performed before surgery, on 21st and 84th days, and 5 months after surgery. The blood picture of animals of the experimental group was characterized by moderate erythrocytopenia and leukocytosis, a decrease in concentration of hemoglobin and an increase in the concentration of platelets. The increase of the number of stab neutrophils observed in white blood and emergence of young forms (metamyelocytes) indicated a regenerative form of the nuclear shift. When analyzing the red blood parametres of all animals after 21 days of the experiment, a significant decrease in the number of erythrocytes was observed, which persisted up to 84 days compared with the control group and pre-surgery values. Reduction of the number of red blood cells led to a significant decrease in concentration of hemoglobin and hematocrit. At the same time, the size of erythrocytes was slightly changed, the width of their distribution by volume increased. A tendency to decrease is also noted in the content (MCH) and concentration (MCHC) of average cell hemoglobin in the erythrocyte. Recovery of blood parameters in relation to the presurgery and control values occurred after 5 months of the experiment. The results of the study showed that the inflammatory process did not go beyond the extremities of the general adaptation syndrome that develops after surgery in case using osseointegrated percutaneous implants.