THE HORMONAL AND METABOLIC DISORDERS OF HE-RAT'S REPRODUCTIVE SYSTEM INDUCED BY CHLORINATED ORGANIC SUBSTANCES
The our study demonstrates thai continuous exposure to traffic pollutants impairs reproductive function in experimental animals. The intoxication by polychlorinatcd biphcnyls cause various 'endocrine disruption' performs in reduction of testosterone in blood, increasing levels of estrogens, prolactinc and wide number of other metabolic disorders in tissues of mail reproductive system. In fact, the environmental chemicals having an ami-androgenic properties The comparative evaluation of hormone and sperm parameters and sperm concentrations indicates that polychlorinatcd biphenyls is probably causing the impaired spermatogenesis. Alteration of male reproductive system could be considered a precocious marker of detrimental toxicological effects. In the course of experiment there was given the oximetyluracyly's and "Triovif's estimation of the influence on metabolic changes, developed in androgendepending organs of he-rats that were intoxicated with sovol. The given data show the efficient lowing of toxic effects of polychlorinated biphenyls on metabolism and functions of reproductive tissues which determines the perspectives of further deep study and search methods of the pharmacological defense of men and animals under the influence of strong supcrecotoxicants.