Possibilities of correction of microecological status in children with bronchial asthma
Aim: to assess the potential of Zosterin-ultra in correcting changes. microelement status and the state of intestinal microbiota in children suffering from bronchial asthma. Materials and methods. A total of 32 children with moderate bronchial asthma (BA) of moderate severity (age (10,12 ± 3,79) years) were examined. Patients underwent standard allergological examination, as well as blood tests for mass spectrometry of microbial markers for the evaluation of intestinal microbioma, chemical analysis of blood serum with the determination of 34 elements by mass spectrometry with inductively coupled plasma. Results. About a third of those surveyed had deficiency of iodine, phosphorus and selenium. With a frequency of about 10%, there was a deficiency of sodium, calcium and copper. In 40% of children with asthma, elevated levels of iron and zinc were detected, in a third of patients - copper, nickel, chromium and vanadium; in 10% - aluminum, calcium, cadmium and iodine. Against the background of the application of the adsorbent “Zosterin-Ultra-60”, the average level of such trace elements as cadmium (p <0.001), molybdenum (p <0.01), magnesium, calcium, lead, potassium, silicon and germanium decreased with a significant increase in the mean (p < 0.01), and sodium (p < 0.001) and phosphorus (p < 0.01). The state of the intestinal microbiota in the examined children was characterized by a decrease in the number of most representatives of normobiota, the absence of certain species of bacteria and the excessive growth of Ruminococcus spp. and Streptococcus mutans. It has been established that the use of adsorbents significantly increases the number of bacteria such as Lactobacillus spp., Bifidobacterium spp., Staphylococcus spp., Eggerthella lenta, Clostridium ramosum and Bacteroides fragilis and decreases Ruminococcus spp., Streptococcus mutans (anaerobic). Conclusion. A decrease in the number of toxic metals in the blood, an effect on the state of the intestinal microflora, and the absence of undesirable effects make it possible to use the Zosterinultra- 60 adsorbent in the complex treatment of asthma in children living in ecologically unfavorable regions and megacities.