DYNAMICS IN CYTOKINE PROFILE OF INFANTS WITH ALLERGIC DISEASES
The authors have monitored dynamics in local and system synthesis of cytokines, IgE immunoglobulin E and cytokine regulation in progression of allergic inflammation of 200 infants suffered from various forms of allergic diseases (bronchial asthma, atopic dermatitis, allergic rhinitis, combination of bronchial asthma with allergic rhinitis, other combinations). Progression of children's allergic diseases showed increase in production of interleukins 4 and 13 as well as IgE immunoglobulin E, which was growing by the age of 7-8 years old, coupled with decrease in interferon level. They detected correlation relationships of and changes in regulatory content numbers of IgE immunoglobulin E, interleukins 4 and 13 during bronchial asthma, allergic rhinitis, atopic dermatitis and at various combinations of such diseases. They draw an inference that dynamics in cytokine profile is a diagnostic and prognostic criterion for progression of allergic diseases at preschool age