Study of the effect of prolonged hypothermic storage on platelet concentrate
The article presents the results of a comparative analysis of the quality indicators of apheresis platelet concentrate prepared on two additive solutions: experimental additive solution containing sodium fumarate and SSP+ solution. The parameters of the thrombogram, metabolism, hemostatic potential, markers of activation and apoptosis for prolonged periods (15 days) of storage at a temperature of 4 ± 2 °C were studied. The data obtained indicate the expediency of using additional solutions during cold storage of platelet concentrate. The cellular composition, sufficient level of metabolism and hemostatic ability of platelets were maintained throughout the observation period. The values of safety indicators corresponded to the requirements of regulatory documents. An additional solution with the inclusion of sodium fumarate is a promising development for prolonged cold storage of platelet concentrate.