AMINO SALICYLIC ACID DERIVATIVES IN THE TREATMENT OF ULCERATIVE COLITIS
ifferent aspects of clinical application of amino salicylic acid derivatives for ulcerative colitis are reviewed. Mechanisms of action of these medications and their role in the suppression of the development of different stages of inflammation are analyzed in details. Overall characteristics of different derivatives of amino salicylic acid and peculiarities of pharma-codynamics determining the appropriateness of their clinical application are described. The indications of these group agents' administrations are specified with pointing out to the schemes of treatment and duration of their use for exacerbation and remission of ulcerative colitis. Detailed account is given for the use of various derivatives of amino salicylic acid in the treatment of distal forms of ulcerative colitis. Special accent is made on the duration of supportive treatment with these drugs according to the end-point: prophylaxis of the disease relapse of or prevention of colon cancer development. The mechanism of anticancer action of amino salicylic acid derivatives and appropriateness of their use as a mean of preventing cancer development in patients with ulcerative colitis according to controlled trials are described.