INFLUENCE OF EXPERIMENTAL OBESITY ON RESISTANCE OF THE MUCOUS MEMBRANE OF THE ORAL CAVITY TO MICROFLORA
In an experiment on 10 purebred dogs, the dynamics of changes in the stability of the oral mucosa epithelium to microflora was studied against the background of the development of experimental obesity. The quantitative indicators of key cells in smears from the oral cavity expressed as a percentage were used as a criterion for analysis. Modeling obesity was carried out according to our methodology, which included administering 1 unit of insulin per 1 kg of animal weight 10 minutes before feeding, followed by feeding with standard balanced feeds in accordance with regulatory indicators, and then eating foods enriched with animal fats without restrictions. It has been established that against the background of the Diet-Induced Obesity, there is a persistent tendency to increase the number of key cells in the test material. Moreover, starting from 21 days, the differences became significant (˂ 0.05), and after 28 days they increased (P ˂ 0.05). The dynamics of the number of key cells in the material from the oral cavity indicated that, against the background of obesity, there is a progressive tendency to decrease the effectiveness of the protective properties of the immune system of the mucous membranes, which creates the prerequisites for the development of infectious pathology.