Tissue engineering scaffold subtypes and methods for the production thereof
Relevance: the production of the main tissue-engineered acellular scaffolds (extracellular matrixes, ECM) described in this article has become a recognized method in the rapidly developing field of regenerative medicine. The aim of the study was to review current literature that analyzes problems of creating artificial three-dimensional scaffolds mimicing natural ECM composition and functions and to compare the advantages of using different native ECMs obtained from tissues and organs, as well as synthesized in vitro are compared. Materials and methods: literature review. Results: in this work the ECM characteristics in vivo and in vitro, as well as the varieties of modern techniques of decellularization, with an emphasis on organ- and tissue-specific ECMs, were analyzed. Conclusions: a detailed comparison of the advantages and disadvantages of various types of acellular scaffolds was carried out.