The focal forms of tick-borne encephalitis in children in Primorye
There have been presents the results of studying the characteristics of focal forms of manifestation of tickborne encephalitis in 31 children. Focal forms of tick-borne encephalitis is characterizing by extremely severe symptoms, with severe general toxic and cerebral symptoms, severe lesions of the nervous system with the development of seizures, loss of consciousness, peripheral flaccid paralysis, spastic hemiparesis nature, occurrence of pathological Iambic signs of strabismus, ptosis, bulbar syndrome, and in 22,6% of cases we observed during two-wave of the disease. The results of the immunological responses of systemic cytokine status have been presented. There have been defined the unidirectional changes in the systemic cytokine status: hyperproduction of INF¥ and IL-10. In the process of the disease was noted the active reduction of IL-10, which probably indicates the development of Th1/Th2 type of immune response.