BIOGENIC AMINES IN UMBILICAL BLOOD OF INFANTS BORN BY MOTHERS WITH UNDIFFERENTIATED HEPATOPATHIES
Objective. To determine the severity of the biogenic amines level changes in the umbilical blood of infants born by mothers having hepatic function various disorders during pregnancy. Materials and methods. The biogenic amines values were determined in the umbilical blood of 89 infants born by mothers having been diagnosed the alanine aminotransferase (ALT) (the 1st group), the bilirubin and the ALT (the 2nd group) levels increase or the bilirubin level (the 3rd group) before and during pregnancy. The control group was formed of 28 newborns their mothers pregnancy course having been physiologic. Results. Hepatopathy of a not infectious origin was determined to effect the pregnancy outcome, the newborn's early neonatal period course and his (her) adaptation negatively. The maximal catecholamine metabolism in newborns was registered in case the cytolysis syndrome was combined with hyperbilirubinemia in pregnant women. Conclusion. The infants born by mothers having the ALT level exceeding 90 U/l and/or non-conjugated hyperbilirubinemia should be referred to the risk group for the adaptation impaired when an additional monitoring of the central nervous system as well as of other systems was necessary. When the ALT level exceeded 90 U/l and/or non-conjugated hyperbilirubinemia was diagnosed the woman should be consulted by a hepatologist.