Some aspects of pathogenetic mechanisms of placental insufficiency development in group of pregnant women at high risk
In group of pregnant women at high risk studies of extra- and intraplacental blood flow indicators condition, echography, an antenatal cardiotocography, the cytokin status and the analysis of their correlation allowed to develop the concept, which discovers one of pathogenetic mechanisms of development of placental insufficiency which consists in an imbalance of cytokin system, which leads to insufficient invasion cytotrophoblast, to violation of gestational transformation and a blood flow in spiral arteries of uterus, to decrease in a vascularization terminal villi from I-st trimester of the gestation period timely identification of which allows to predict placental insufficiency before its clinical manifestations.