BIOCHEMICAL MECHANISMS OF DEVELOPING HEART PATHOLOGY DURING ISCHEMIA AND TISSUES REPERFUSION IN EXPERIMENT
This article describes biochemical mechanisms of the heart function and structure lesion during the experimentally set reperfusion syndrome. It is well known that ischemia and reperfusion cause activation of proteinases in the heart tissues, which is manifested by a major growth of activity of proteolytic enzymes and suppression of their inhibitors in the supernatants of the heart homogenates. These changes can damage the heart tissue, which can lead to disorders of the heart bioelectrical activity.