In memory of the academician N.N. Trapeznikov (1928 - 2001) (To the 90th anniversary)
Relevance: The academician N.N. Trapeznikov has led the development of original Soviet titanium knee, shoulder and hip joint endoprostheses. They could completely restore the limb function and were much cheaper than the foreign analogues. His pedagogical activity, articles, textbooks and manuals also deserve high praise. Purpose of the study: to show the main milestones of N.N. Trapeznikov's activity. Results: In 1974, N.N. Trapeznikov was elected a corresponding member of the Academy of Medical Sciences of the USSR, and in 1978 - its full member (RAMS since 1992). In 1977, N.N. Trapeznikov with a group of co-authors was awarded the State Prize of the USSR for the experimental substantiation, clinical development and introduction of the method of large bone allografts. In the future, the successful development of that area of oncology was twice marked by N.N. Petrov's awards of the USSR Academy of Medical Sciences (1980,1987). A series of works in the field of immunodiagnostics, immunotherapy and immunochemotherapy of tumours published in the late 1970s and early 1980s has put him forward as a prominent clinical immunologist. The most important areas of that field were: specific and non-specific immunotherapy of malignant tumours, immunochemotherapy and prevention of metastasis in skin melanomas, immunotherapy with the patient's activated lymphocytes. At that time, the use of interleukins has been a completely new approach in cancer therapy. In recent years, N.N. Trapeznikov has been engaged in endoprosthetics of bones and joints in patients with bone tumours. Endoprostheses of knee and hip joints, the diaphysis of the femur, the proximal end of the shoulder from a new isoplastic material are widely used till today to solve a number of problems of stable fixation of implants. The author substantiates a complex approach to therapy using organ-preserving surgical interventions, highly active antitumour drugs, irradiation, and influence on the immune status of the body. Conclusion: N.N. Trapeznikov has definitely been one of the creators of modern oncology and, above all, of its scientific foundations.