THE INFLUENCE OF FENIBUT AND ITS SALT WITH SUCCINIC ACID ON ANIMALS' RESISTANCE TO FORCED DYNAMIC AND STATIC PHYSICAL LOADS
It was proved that the creation of fenibut salts with organic carboxylic acids allows to get substances with more evident pharmacological activity. Aim. a comparative study of the influence of fenibut and its salt with succinic acid on animals' resistance to forced dynamic and static physical loads. METHODS: The experiments are carried out on white nonlinear rats and male mice, using the test of forced inescapable swimming with a load, the test of suspension on a horizontal net, the methods of statistic analysis: Kruskal-Wallis univariate analysis, Newman-Keuls test. Results. Fenibut and, to a larger extent, its salt with succinic acid performed statistically significant increase of the time of animals' swimming before fatigue, both in one-fold and repeated tests – they increased exercise performance in the conditions of forced dynamic work; precipitated the recovery of efficiency under repeated forced dynamic loads. In the test of suspension on a horizontal net the fenibut succinate > fenibut increased the latent period of the first fall from the net and the total time of remaining on it. They increased the efficience of animals under the forced static physical load. Conclusion. Fenibut and its salt with succinic acid increase the exercise performance of animals under the forced physical loads of both dynamic and static type, and precipitate adaptation to repeated dynamic loads. The fenibut salt with succinic acid statistically significantly surpasses fenibut in activity.