The effect of combination treatment on intima-media complex and adhesion molecules in hypertensive patients with different occupational risk
Aim. To evaluate the levels of adhesion molecules and intima- media complex after 6-month antihypertensive treatment with valsartan/amlodipine in hypertensive patients with different occupational risk.Material and methods. Two hundred sixty three patients were enrolled in open prospective study. They were divided into 4 groups depending on occupational risk and were treat- ed with fixed combination of valsartan/amlodipine 160/10 mg. At baseline and at 6 months we performed Doppler ultra- sound study of carotid and brachial arteries and assessed blood levels of sVСАМ-1, sPECAM-1, VEGF, МСР-1 and high- sensitive C-reactive protein.Results. Combination treatment with valsartan/amlodip- ne induced normalization of BP in all groups of patients and reduction in soluble adhesion molecules blood levels and inti- ma-media thickness.Conclusion. Fixed combination of valsartan/amlodipine has high antihypertensive efficacy and improves adhesion molecules blood levels and intima-media thickness in hyper- tensive patients with different occupational risk.