Development of evaluation method for vaccines upon dendritic cells action in vitro
We investigate <i>in vitro </i>action of vaccines upon dendritic cells of newborns and adults using live BCG vaccine and recombinant hepatitis B vaccine. It was shown, that dendritic cells, treated with BCG vaccine, demonstrated semimature phenotype, but stimulated interferon-g production by T-lymphocytes very efficiently. At the same time, hepatitis B vaccine stimulated interferon-g-stimulating capacity of dendritic cells only in adults, with no significant action upon this feature in newborns.