EFFECT OF GLUFIMET ON THE INO- AND CHRONOTROPIC RESERVES OF THE STRESS-EXPOSED MYOCARDIUM
Experiments on rats exposed to inescapable alternating multimodal stressors (noise, rocking, or pulsating light) investigated the effect of glufimet, a new glutamic acid derivative, versus Phenibut on cardiac functional reserves during volume loading and maximum isometric exercise. Glufimet in a dose of 28.7 mg/kg was found to limit myocardial inotropic dysfunction in the stress-exposed animals. This is suggested by an increment in the rates of myocardial contraction and relaxation and in intragastric pressure during volume loading and by that in the rate of myocardial contraction and relaxation, in left ventricular pressure and the highest-intensity performance of structures during maximum isometric exercise in the stressexposed animals receiving glufimet. The latter was ascertained to have higher efficacy than Phenibut.