Concentration of triglycerides in blood serum in different chicken breeds as affected by the polymorphism of FABP2 and PPARG genes
Excessive deposition of abdominal fat in chickens reduces carcass quality, feed efficiency, dressing percentage, egg production; it also gives rise to the problem of utilization of the excessive fat. The systematization of knowledge and the study of the influence of the detected single nucleotide polymorphisms (SNPs) in FABP2 (fatty acid binding protein-2) and PPARG (peroxisome proliferator-activated receptor-γ) genes on lipid metabolism and, in particular, on the concentration of triglycerides (TG) in blood serum is an understudied aspect important for the selection of chickens aimed at the reduction of the of abdominal fat content in the carcass. The purpose of the study presented was to analyze the TG content in the blood serum in chickens of different gene pool breeds in connection with SNPs in their FABP2 and PPARG genes. The genetic heterogeneity of chicken populations (n=199) in terms of SNPs of the FABP2 gene (rs314111163/ rs313829340) and PPARG (rs314476701/rs316237745) was revealed. The significant differences (p≤0.01) were found in the serum TG concentrations between the groups of Rhode Island chickens with different genotypes of rs314476701 SNP in PPARG gene. In Pushkin breed the carriers of the AG genotype had significantly (p≤0.05) lower serum TG concentrations in compare to the carriers of the AA and GG genotypes (AG˂AA˂GG). The characterization of genetic variations and the genetic structure of populations on the basis of the SNPs in FABP2 and PPARG genes is a valuable instrument for the assessment of gene pool populations and, potentially, for the marker-assistant selection of chicken.