State of microcirculation and vascular reactivity in chronic intoxication with nicotine, ethanol and opioids
Drug abuse - сcigarette smoking, alcohol, heroin - is the factor of risk, which influences the appearance of different cardiovascular pathology, which frequently leads to premature death. PARTICIPANTS: A total of 66 patients at age (M±SD) of 27,4±7,1 years. The first group (control) composed the healthy persons - 15 people. Second group - smokers - 15 people. Third group - the nonmedical users of heroin - 25 people. The fourth - patients with chronic alcoholism - eleven person. On ICD- X in all patients is verified the second stage of drug dependence. In differential diagnostics consumption / withdrawal drug abuse is used the statistical procedure of the reference area under receiver operating characteristic curve (AUC). Microcirculation investigated with the Laser doppler flowmetry (ЛААК -002) and were conducted cutaneous tests with the vaso active substances - acetylcholine, adrenaline, histamine. This procedure makes it possible to obtain idea about the proceeding microcirculatory processes and to connect them with the clinic of «chemical» dependence, to estimate the risk of endothelial disfunction, to forecast the stages of disease.