RS5743611 POLYMORPHISM WITHIN THE TLR1 GENE IS ASSOCIATED WITH SEVERE CORONARY ATHEROSCLEROSIS IN FEMALE PATIENTS WITH CORONARY ARTERY DISEASE
Aim. To assess whether the polymorphisms within the TLR (Toll-like receptor) genes are associated with severe coronary atherosclerosis in patients with coronary heart disease (CAD). Methods. We recruited 292 consecutive patients with CAD: 53 (18.15%) females and 239 (81.85%) males. Severity of coronary atherosclerosis was evaluated using coronary angiography and SYNTAX score. Genotyping was carried out in 96-well format using the TaqMan SNP genotyping assay. Results. Severe coronary atherosclerosis, defined as SYNTAX score > 22, was identified in 112 (38.36%) patients. С/G genotype of the rs5743611 polymorphism within the TLR1 gene was associated with severe coronary atherosclerosis in females (OR = 5.54, 95% CI = 1.54-19.89, p = 0.007). Conclusion. rs5743611 polymorphism within the TLR1 gene is associated with severe coronary atherosclerosis in female patients with coronary artery disease.