Radiotherapy in management of brca-positiveovarian cancer
Cancer cells with the loss of BRCA 1 or BRCA 2 function are unable to repair DNA double-strand breaks anddemonstrate the increased sensitivity to various DNA-damaging agents. We aimed to describe successfultreatment outcomes in two patients with BRCA1-associated ovarian cancer, who showed a complete clinicalresponse to radiotherapy in combination with platinum-based chemotherapy. The progression-free survivalwas 11 months in one case and 8 months in another case.