Experimental Choice of the Regime of the Targeted Impact of High-Intensive Laser Radiation in Endoscopic Interventions on the Colon
Introduction. The literature lacks a unified methodology for safe use of various laser systems for endoscopic devitalization of epithelial neoplasms. No sources were found, where the experimental development of laser coagulation of the colon would be performed in conditions as close as possible to clinical conditions (during intraluminal endoscopy). Purpose. To evaluate the coagulating properties of various parameters of high-intensity laser radiation with the wavelength of 1.06-1.34 µM in animal testing, to work out the optimal modes of safe intraluminal laser exposure to the rectal and colon mucosa in animal testing. Materials and methods. The authors of the article carried out the experiment on laboratory animals (rabbits), which was aimed at the development of optimal modes of laser influence on intestinal tissues. The depth of the lesion of the intestinal wall was studied depending on the power of laser radiation in a constant time of remote exposure. There were selected the optimal parameters of safe mode of laser destruction of neoplasms of the colon mucosa during endoscopic intervention. Results. In the course of the experiment, it was shown that the dose of laser radiation with a wavelength of 1.34 μm (power - 15 W, exposure - 2 seconds) is sufficient and optimal for destruction of tumor tissue of the mucous membrane, limiting the zone of destruction with only mucous membrane, without thermal damage to the muscular layer of the intestinal membrane. Conclusions. Experimental in vivo evaluation of various modes of exposure of high-intensity laser radiation on the colon mucosa allows predicting adverse outcomes of thermal ablation of benign tumors in clinical settings and establishing effective and safe modes of exposure.