Anemia in chronic kidney disease and its impact on the development of the disease
The article discusses the occurrence of anemia in chronic kidney disease. The author explores the question of what tests are necessary to study anemia in a patient with chronic kidney disease, to conduct differential diagnostics of renal anemia, to find out and correct other deficient anemia, and what are the criteria for referral to Nephrology or other specialties of a patient with anemia with chronic kidney disease. A study of special literature has shown that the main cause of anemia in CKD is inadequate production of endogenous erythropoietin, a hormone that affects the differentiation and maturation of red blood cell precursors. Other contributing factors have been recognized in recent years as impaired bone marrow response to erythropoietin caused by uremic toxins , inflammation, reduced iron availability for erythropoiesis and increased hepsidin levels, shortened red blood cell half-life (RBC), or a lack of vitamins (vitamin B12 or folic acid). It was concluded that the diagnosis of anemia due to CKD is an exception diagnosis, so it is necessary to exclude other causes of anemia, especially iron deficiency