The peptide drug for intranasal administration in pediatrics and psychoneurology
The author focuses on Russian neuropeptide drug Semax, the synthetic ACTH 4-10 fragment analogue, intended for intranasal administration. General information on the drug and its concise history are provided, Semax mechanisms of action, pharmacological and pharmacokinetic properties, indications/contraindications for its use, dosage/administration peculiarities in pediatric patients (0-18 years), and Semax side effects/undesired events are described as well. Russian and foreign data, derived from experimental and clinical research on Semax are reviewed, along with the obtained experience and perspectives of the drug’s use.