Expression of the transcription factors NF-kB and HIF-1 in squamous cell carcinomas of the head and neck: association with disease prognosis
There was studied an expression of transcription factors NF-kB p65, NF-kB p50 and HIF-1 in the tissue of squamous cell carcinomas of the head and neck. An association of development of regional metastasis of the disease with increased expression of the transcription factor NF-kB p50 was revealed. After treatment there were found relapses within 3 to 47 months in 10 patients, regional lymph node metastases in 3 patients, 12 patients died. Metastasis-free survival of patients with squamous cell carcinomas of the head and neck depended on the threshold level of an expression of the transcription factors NF-kB p65, p50, HIF-1 equal to 9.6, 7.8 and 9 CU/mg protein respectively.