DIAGNOSTIC CRITERIA OF COLORECTAL CANCER IN KAZAKHSTAN
Morbidity rate of colon and rectum cancer increases worldwide. In 2016, there were more than 1.5 millions of new colorectal cancer cases. However, quality of timely diagnostics of the disease is unequal and strongly depends on the development of a healthcare system. In this connection, clinical picture of the cases newly revealed varies in different regions of the World, since it depends on the stage at which the disease was recognized. The goal of the study was to reveal clinical and laboratory criteria which are the most valuable for population of the Kazakhstan. For this purpose, a retrospective analysis of 1570 cases registered at oncology centers of 4 regions of Kazakhstan was performed. For the analysis, method of construction of ROC-curve was applied. As a result, qualitative assessment of sensitivity, specificity and prognostic value of diagnostic tests for revealing the studied disease was performed within analyzed population. The study results shows that hemoglobin and ESR possess good prognostic value for diagnostics of the concerned diseases (sensitivity 67.2% and 79.7% accordingly, AUC > 0.8 for both cases).