Genetic Aspects of Mycobacterium tuberculosis Drug Resistance and Virulence
Drug resistance of Mycobacterium tuberculosis, along with increased virulence of new epidemiologically dangerous lines are a global problem, the solution of which is necessary to create new anti-TB drugs. The study of the genetic mechanisms of the formation M. tuberculosis strains with multiple drug resistance is the basis for the search for new antituberculous drugs biotargets. To date, the molecular genetic links between genes controlling drug resistance and virulence have not been adequately studied and require special attention. In this review we consider the mechanisms of drug resistance and virulence genes interaction in M. tuberculosis.