MOLECULAR AND GENETIC ASPECTS OF OBSTETRIC COMPLICATIONS
The article provides an overview of international scientific research devoted to the study of various genes role in the development of obstetric pathology. The genes of hemostasis, folate metabolism, genes of renin-angiotensin-aldosterone system, detoxification system, endothelial dysfunction, immune response, genes of sex hormones’ receptors, antioxidant defense are considered. The data concerning genetic predisposition to gestational complications are presented. The study of the molecular genetic mechanisms in the development of "great obstetrical syndromes" will bring us closer to 4Р-medicine, built on the principles of a personalized approach to human health and integrating the concepts of personalization (an individual approach to each patient), prediction (creating a probabilistic forecast of obstetric pathology), prevention (prevention of obstetric complications), participation (motivated patient participation).