EFFICACY OF MYACALCIC IN HEAVY MECHANICAL INJURY, GLUCOCORTICOUS OSTEOPOROSIS AND IN OSTEPORETICAL RATS WITH INJURY
The work is devoted to assessing the effectiveness of salmon calcitonin (“Miacalcic”) in severe mechanical injury, in case of glucocorticoid osteoporosis and injury occurring against the background of osteoporosis. The study used physiological, pathophysiological, X-ray, biochemical, and statistical research methods. The efﬁ cacy of the drug was determined by comparing the life expectancy of animals with a shocktype lethal course of a post-traumatic reaction, which develops with a standardized impact and mild glucocorticoid osteoporosis in two groups of animals (calcitonin-treated and untreated). The effectiveness of salmon calcitonin in glucocorticoid osteoporosis and injury was also studied by changing the complex of blood biochemical parameters in two groups of rats that were injected with the preparation (test group 2) and rats with osteoporosis and injury without drug administration (control group 2). In animals with a combined pathology, the protwash efﬁ ciency of myacalcics was established. The curative effect of myacalcic in shock is probably realized through the mechanism of its neurotropic action on the central nervous system and, in particular, on the hypothalamic-pituitary system. In this way, the concentration of PTH and TSH in the blood increases 1.4 times (p <0.05) and 1.2 times (p <0.05), respectively. Miacalcium probably also reduces the intoxication of the body with toxic intestinal products. Due to this mechanism, the concentration of IL-6 in the blood decreases by 1.3 times (p <0.05), and the concentration of TNF-a - by 1.6 times (p <0.05).