EXPERIMENTAL EVALUATION WOUND-HEALING AGENT TO TREAT WOUNDS CAUSED BY A DOG BITE
The problem of effective treatment of wounds caused by dog bites, is very important. Important role in the surgical treatment of injuries belongs to their local medical treatment. The aim of the work was to identify characteristics of the course of reparative processes in wounds from small laboratory animals, which are consistent with the mechanism of applying the dog bite. The experiment included 36 rats weighing 150 to 200 grams. The wound was simulated by a circular cut-off of the skin with a diameter of 5 cm to the fascia. In the area of the defect was applied to a medium containing a high titer of microorganisms, most commonly released from the wounds caused by dog bites. Animals are divided into 6 groups based on local treatment: I group - control, II comparison group -maz levomekol, III group - gel prontosan, IV control group - a solution of chymotrypsin, V experienced group - gel "Entomiks», VI experienced group - gel Carbopol. Biopsy and comparative microscopic examination at 6, 13, 18 hours. Morphological analysis of the regeneration processes in the wounds, simulating dog bites in 6 groups of animals revealed significant features in the rate of purification of leukocyte-necrotic layer and the relief of the inflammatory process, the timing of the beginning of the maturation of the connective tissue and its differentiation, as well as the processes of epithelialization. The greatest efficiency of the test group showed drugs (Carbopol gels and gel "Entomiks") will clean the experimental wounds from leukocyte-necrotic masses have 10 days to ensure their healing already in 15-16 hours. Stated synchronous development of epithelial and connective tissue components in the area of defect healing with minimal scarring.