IDENTIFICATION OF AFLATOXINS AT CLINICAL IZOLYATOV MIKROMITSETOV ASPERGILLUS FLAVUS
It is known that the metabolites of A. flavus have a pronounced hepatotropic, carcinogenic, have a tropism for embryonic tissues, the ability to inhibit protein synthesis, RNA and DNA of eukaryotic cells, globulins and antibodies, causing the development of hyperergic reactions. They are also able to modify the properties of bacteria, aggravating during the infection process. These one-of the most dangerous toxins these fungi is aflatoxin B1. The clinical isolates of A. flavus. The presence of aflatoxin B1 was determined by HPLC after the cultivation of mushrooms in a medium Saburo. Studies have shown that all clinical isolates of A. flavus, isolated from patients with diseases caused by opportunistic pathogens (UPM) had a typical biological properties and toxicity possessed (Dl50 2,2 ± 0,16 / lg), in addition, they were the producers of aflatoxin B1.