RISK FACTORS AND CHRONIC KIDNEY DISEASE IN SEPARATE COHORT GROUPS
Objective. To determine the risk factors and early symptoms of chronic disease for subsequent nephroprotective therapy. Materials and methods. Eleven hundred and nineteen volunteers — workers of Minsk (n=528) and Gomel (n=591) industrial enterprises were examined. Every screening participant filled an inquiry form specifying his/her age, gender, type of activities, medical data. In addition the blood pressure, weight, height, waist, and hip were measured, blood and urine samples were assayed. The blood and urine creatinine concentrations were determined and the glomerule filtration rate was calculated by the MDRD equation, the blood glucose level and lipids spectrum were studied. Urine microalbuminuria was determined and the urine albumin/creatinine ratio was calculated. Results. Symptoms of chronic kidney disease were found in 32 (6.06%) persons from the first group and in 25 (4.23%) ones from the second group. Additionally the following risk factors were determined: arterial hypertension (32.2% and 22.8% of participants respectively), hypercholesterolemia (26.9% and 13.2% respectively), diabetes mellitus (0.94% and 0.33% respectively). Conclusion. Early stage of chronic kidney disease occurrence among the Republic of Belarus population was found to achieve 6% along with arterial hypertension and metabolic disorders generating conditions for nephrosclerosis progressing and for increase of the number of patients at the terminal stages of diseases requiring appliance of such costly methods of treatment as dialysis and kidney transplantation.