MORPHOLOGICAL ASSESSMENT OF THE FETOPLACENTAL COMPLEX IN PATIENTS WITH THROMBOPHILIA, TAKING INTO ACCOUNT THE TIMING OF THE COMPLEX ANTITHROMBOTIC THERAPY
In order to identify the major histologic features of formation of placental insufficiency (PI) in pregnant women with thrombophilia, and to assess the rehabilitation of placental structures in women, denounced the pregnancy on a background of complex therapy koagulopaticheskih changes associated with thrombophilia, was investigated last 671 of which 117 patients from the Serial treated, starting with pregravidal stage (1L subgroup) and 554 of the placenta from patients receiving similar therapy only during pregnancy (subgroup 2L). As a control, were examined 25 placentas from women with physiological pregnancy. Methods of investigation were to Serial microscopic description, organometrii Gistol gistostereomorfometrii. The study found that the latter patients, receiving correction gemostaziologicheskih disorders associated with thrombophilia, starting with pregravidal phase, characterized by suppression of the manifestations of DIC in the fetal and maternal blood channels, the lack of dishronoza in the differentiation of chorionic villous structures and degenerative changes at the level stromal component of the placenta, activation of compensatory-adaptive reactions in the form of hyperplasia of vascular differentiation of placenta. As the features of placentas from patients who have not received pregravidal correction thrombophilia, has been a considerable increase of structural defects in the form of dissociated maturation of villous chorion.