Changes in the hemostatic system in patients with hereditary connective tissue disorders in early pregnancy
Objective. To compare the parameters of coagulation hemostasis and fibrinolysis and the levels of fetoplacental unit hormones in young women in early pregnancy in relation to the degree of hereditary connective tissue disorders and thrombosis prophylaxis. Subject and methods. The parameters of coagulation hemostasis and fibrinolysis and the levels of fetoplacental unit hormones were studied and correlations between vascular resistance indices in the uteroplacental unit and hemostatic system parameters were determined in 418 patients with hereditary connective tissue disorders and in 313 pregnant women without these conditions. Results. The use of low-molecular-weight heparins in combination with dydrogesterone was found to improve the indicators of uteroplacental unit hormones in the patients with hereditary connective tissue disorders. Conclusion. Thrombosis prophylaxis and dydrogesterone therapy in early periods in patients with hereditary connective tissue disorders can improve uteroplacental unit parameters.