ENDOCRINE STATUS AND THE LEVEL OF BCL2 AND P53 PROTEIN EXPRESSION IN PANCREATIC ISLETS OF RATS WITH EXPERIMENTAL DIABETES MELLITUS
Peculiarities of insulin synthesis, the expression of apoptosis markers and proliferation of beta cells in laboratory rats with experimental diabetes mellitus were studied. With the development of diabetes mellitus remained beta cells compensatory hypertrophy and insulin concentrations are increased. The production of anti-apoptotic protein Bcl2 reduced to a considerable extent. Development of diabetes significantly reduces the proliferative activity of pancreatic islets endocrinocytes.