Genetics in Development and Treatment of Nicotine Dependence
The development of nicotine dependence (ND) is a complex process influenced by many environmental and genetic factors. Most likely, nicotine dependence results from the exposure to environmental risk factors in individuals who have a number of predisposing alleles in their genotypes. This review briefly highlights some candidate genes whose protein products are involved in the nicotine metabolism and may influence smoking behavior and the effectiveness of smoking-cessation treatment.