FOLLOW UP OF SKIN TESTING WITH INHALATION ALLERGENS IN PATIENTS WITH COMORBID ALLERGIC BRONCHIAL ASTHMA AND ALLERGEN-SPECIFIC IMMUNOTHERAPY
To assess the effect of allergen-specific immunotherapy (ASIT) on the parameters of specific allergic diagnostics with non-infectious allergens in patients with moderate allergic bronchial asthma, comorbid with allergic rhinitis and atopic dermatitis in the presence of polyvalent sensitization, a prospective, randomized controlled trial was conducted with 132 patients included. The first group of patients (n=88) against the background of basic anti-inflammatory therapy during the 3-year period had ASIT by four types of allergens identified during specific skin testing; the second group of patients (n=44) received only basic anti-inflammatory therapy. Analysis of the dynamics of the severity of skin-allergic samples showed that patients in the 1st group had significantly lower levels of pronounced tests and significant tests with an increase in the number of negative test results (p<0.005). By the end of the third year of observation, in the 2nd group of patients, the dynamics towards a decrease in skin sensitivity to allergens was not detected.