EXPERIMENTAL JUSTIFICATION OF "PERMAFOAM" BANDAGE AND POLYVALENT PYOBACTERIOPHAGE "SEXTAPHAGE" APPLICATION IN TREATMENT OF CHRONIC ANAL FISSURE
Present experimental investigations reveal the efficacy of postoperational wounds healing after chronic anal fissure resection when treated by applying wound-healing bandage “PermaFoam” and antibacterial polyvalent pyobacteriophage “Sextaphage”.A model of anal fissure was created on 48 pubescent white outbread Wistar mice according to V.S. Groshilin procedure. After chronic anal fissure formation a part of animals (n=6) were removed from the experiment on the 30th day. The edges of the experi-mental fissure were resected en block to make a histological investigation aimed at morphological identification.Morphological study revealed that in a week time after PermaFoam bandage and pyobacteriophage Sextaphage treatment animals of the main group showed quicker reduction of exudative reaction with simultaneous formation of granulation tissue. On the14th day both in the main and in comparison groups we noted obliterated sclerotic changes with activation of fibroblasts and macro-phages. At the same time, obliterated chronic inflammation preserved in the group of comparison. Time of full healing of postoperational wound in the main group was 16±0.51 days, in comparison group - 19±0.42 days.