Muc2 KNOCKOUT MICE AS A MODEL FOR TESTING APPROACHES TO ALTER GUT MICROBIOTA
Gut is inhabited by numerous of bacteria interacting with the immune system of the host. Disturbance of the gut homeostasis leads to various pathological states, which are to be treated by changing of microbiota. The study demonstrate the effects of microbiota alteration on viability of mice with deficient barrier function in the gut (Muc2-/-). The susceptibility of Muc2-/- mice to changing of microbiota suggesting the mice as an appropriate model for testing approaches to alter gut microbiota.