ACUTE TOXICITY OF NEW PROBIOTIC VETOM 21. 77
The paper is devoted to defining the class of toxicity of new vetom probiotic. The research on acute toxicity was carried out on the basis of methods of OECD, TEST NO420:2001 “Assessment of acute toxicity at intragastric intake by means of the fixed dose method” international standard applied in testing methods on the impact of chemical production on the human body. The researchers used 40 experimental mice of the same gender. The specimen was applied orally once a day dosed as 5, 50, 300, 2000 and 4000 mcl/kg of mass during 5 days. The research on acute toxicity was conducted during 14 days. The animals of control group didn’t use the specimen. The animal response was investigated in 30 minutes and every 24 hours. The assessment was based on physiological condition of mice, livability, mass changes and morphometric analysis of organs. The physiological condition of experimental animals didn’t c hange and the authors observed 100% livability. The investigated specimen is referred to IV toxicity class.