MORPHOLOGICAL CHARACTERISTICS OF IMMATURE ANIMALS’ SEMINAL VESICLESAFTER CYCLOPHOSPHAMIDE-INDUCED IMMUNOSUPPRESSION
According to WHO, about 25 % of deaths among children under 5 are determined by unfavorable environmental factors. Each year environmental risks, such as indoor and outdoor air pollution, passive smoking, and water that does not meet health criteria, kill 1.7 million children under the age of 5. The interrelation of the structure and functions of the immune organs with the basic bodily regulatory systems contribute to the fact that immunoactive states remain the main causes of morbidity and mortality, especially in children. The male reproductive system is particularly sensitive to immune status disorders due to the abundance of actively dividing cells and high inherent metabolic level. Seminal vesicles are one of the most important male supplementary organs, which form about 60 % of the seminal fluid.The objective of the study was to examine changes in morphometric parameters of seminal vesicles of immature white rats under immunosuppression.Materials and Methods. The study was conducted on 60 immature white male rats. The immunosuppressive state was simulated by administering cyclophosphamide intramuscularly (1.5 mg/kg body weight) for 10 days. The animals were withdrawn from the experiment in 1, 7, 15, 30 and 60 days after discontinuation of drug administration under ether anesthesia. The authors determined absolute organ mass, calculated its volume and relative mass, measured its length, width and thickness. In seminal vesicles the authors examined epithelial cell height, the larger and smaller diameters of epithelial cell nuclei and their volume.Results. The most apparent changes in morphometric parameters were established at early observational stages (1st, 7th and 15th days). It can be explained by certain susceptibility of seminal vesicles to immunosuppressive effects as a result of age-related structural and functional immaturity and imperfection of regulatory processes at the organ and systemic levels