Dynamics of Histamine Level in Chemical Neurolysis in Patients with Colorectal Cancer
It is known that pain syndrome is associated with the formation of pain mediators, among them histamine is one of the major. The study analyzed the intensity of pain syndrome in patients with colorectal cancer depends on the biochemical response of the organism to the pain. While investigating the dynamics of histamine in the pre- and postoperative period, we have studied the dependence of pain intensity on the quantitative characteristics of mediator. In the postoperative period there had been analyzed standard analgesia with prolonged narcotic analgesics and prolonged epidural analgesia with chemical neurolysis. We maed a conclusion on the effectiveness of pain relief on the basis of the developed technique of epidural chemical neurolysis by a comparative analysis of the dynamics of the level of histamine.