Effect of Combination of Hypertonic Solution and Hyaluronic Acid on Mucociliary Clearance in Patients with Lung Diseases
One of the most important defense mechanisms of bronchopulmonary system is mucociliary clearance (MCC). Patients with bronchiectasis, cystic fibrosis, and chronic obstructive pulmonary disease have MCC dysfunction. Scientific studies and clinical experience of using 7% hypertonic solution and hyaluronic acid for long-term treatment of cystic fibrosis proved the efficacy and safety of these drugs and positive effect on MCC. The article shows the efficacy of using a combination of 7% hypertonic solution and hyaluronic acid in patients with bronchiectasis, chronic obstructive pulmonary disease, and chronic rhinosinusitis. In addition, the article touches upon the possibility of using this combination for viral pneumonia in patients with COVID-19 due to efficacy and safety of drugs.