THERAPEUTIC APPROACHES IN FOCAL SEGMENTAL GLOMERULOSCLEROSIS
Aim of our study was evaluation of glucocorticoid and cytostatic therapy effectiveness in patients with focal segmental glomerulosclerosis. Materials and methods. The immunosuppressive therapy effectiveness studied in 32 patients with focal segmental glomerulosclerosis. All patients diagnosis focal segmental glomerulosclerosis based to morphological examination of the kidneys in accordance with generally accepted criteria. Results. In 81.3% of cases there was a clinical picture of nephrotic syndrome. Isolated glucocorticoid therapy resulted in remission in 18.2 %, in 54,5 % took place clinical and laboratory parameters worsening. In 50% pts therapy was ineffective. The cyclophosphamide therapy results were full and partial remission in 23,8 % and 19,1 % accordingly. Conclusion. In a large proportion of cases studied treatment regimens were ineffective or insufficiently effective. Development of effective focal segmental glomerulosclerosis treatment regimens is an important scientific and clinical challenge.