The changes in the neural and glial composition of the globus pallidus in different terms of the post-radiation period
The research purpose was to study a morphofunctional organization and neuron-glial relationships in globus pallidus in the early and remote periods after exposure to ionizing radiation in a dose of 0.5 Gy with a dose rate of 100, 250 and 660 cGy/h. The experiment was performed on 96 male rats weighing 200-230 g, aged 1.5-2 months. In connection with the experimental conditions, the animals were combined into 16 groups. The material was taken on the 1st day, 6 months later and 1 g after exposure. The object of the study was the cells of the globus pallidus of the rat brain. The survey sections were stained with hematoxylin and eosin, a more detailed characterization of nerve cells was obtained by staining the preparations using the Nissl method. At the same time, counting of neurocytes with various forms of morphological variability was carried out. As a result of the study, it was established that a single exposure to ionizing radiation at a dose of 0.5 Gy causes a complex of reactive and dystrophic-necrotic changes in the globus pallidus neurocytes, the degree of expression of which is proportional to the dose rate and is most pronounced after 1 day after irradiation. After 1.5 years after exposure to ionizing radiation, a damaging effect doesn’t detect. The obtained data indicate transitory violations of motor functions mediated by the influence of the pale sphere.