Antibodies to antigens of beta-cells of the pancreas of operated patients with thyroid carcinoma
The frequency of diagnostic levels of antibodies to antigens of insular tissue (antibodies to insulin (IAA), antibodies to the insular carcinoma apparatus (ICA), antibodies to glutamic acid decarboxylase (GAD)) in patients operated for differentiated cancer of thyroid (DCT) is estimated, as well as their connection with treatment factors and with the carrier of antibodies to tireoglobulin ^B-TG) is studied. The examination of patients with DCT revealed a high ICA percentage (17.2°%), which differed significantly from the control group (0.6%). The frequency of detection of two other types of insular antibodies (IAA and GAD) was compared with that of the identical indices in patients of the control group. The ICA carrier was dominate in patients with overweight (29.3%%) in comparison with those with normal weight (5.3%%), as well as with persons with overweight and normal weight of the control group (1.3 and 0%). The correlation between the carrier of insular antibodies and AT-TG was absent. Probably, the obtained data point to an increased risk of development of the autoimmune variant of diabetes mellitus in patients ICA carrier.