CARDIOPROTECTIVE PROPERTIES OF ADIPINAT 3-OXIPIRIDINE AT CHRONICAL HEART DEFICIENCY IN EXPERIMENTAL STUDY
The catecholamine model of chronical heart deficiency in rats has been used to study the cardioprotective activity of succinat 3-oxipiridine and adipinat 3-oxipiridine. It is found that succinat 3-oxipiridine in a doze of 25 mg/kg produces a positive inotropic effect and eliminates stagnation phenomena in large and small circles of blood circulation. However, it does not eliminate an increase in lipid peroxide oxidation, as well as hypercalemia and a growth of the maker of aspartataminotransferasa myocardium damages. It insufficiently makes corrections of morphological myocardium changes caused by experimental chronical heart deficiency, whereas adipinat 3-oxipiridine in a doze of 40 mg/kg, producing inconsiderable positive inotropic effect, eliminates biochemical shifts and structural myocardium changes as shown by the applied model of chronical heart deficiency. Thus, the experimental study shows that it is purposeful to use succinat 3-oxipiridine for the correction of chronical heart deficiency decompensation, and adipinat 3-oxipiridine for further long-term cardioprotective effect.