IMMUNOLOGIC DEFENCE MECHANISMS DEFICIENCY AS A NEOPLASTIC PROLIFERATION PRODUCING AGENT IN THE PRESENCE OF SEGMENTED INTESTINE MALIGNANT ADENOMA
A complex clinical and laboratory examination of 46 patients suffering segmented intestine malignant adenoma receiving medical treatment in the Railway Clinical Hospital at the Saratov-II Station of the RZhD OAO (Open Joint-Stock Company) Non-Government Healthcare Institution and Regional Clinical Hospital in the city of Saratov State Healthcare Institution during the period from 2009 to 2013 has been held. The article presents the analysis of peripheral blood cell structure, lymphocytes sub-population structure (CD3, CD4, CD8, CD16, CD19) and class G, A, M immunoglobulin level in blood in the presence of segmented intestine ascending segment malignant adenoma at different stages of neoplasia development. Patogenetic correlation between dynamic changes in peripheral blood cell structure and T-dependent and B-dependent immunodeficiency in the presence of the pathology named has been established. The early stages of adenocarcinoma development are characterized by lymphopenia, monocytopenia, reduction in CD16 and CD4 T-lymphocytes level. The metastasis stages are characterized by reduction in CD4, CD8 T-lymphocytes, CD 19 B-lymphocytes and G, M and A immunoglobulin levels in blood.