The efficiency and safety estimation of intradermal autologous serum histamine therapy in patients with chronic spontaneous urticaria
The purpose of our research - to develop a new method of chronic urticaria treatment - autoserumhistaminotherapy and to estimate its efficiency and safety. Materials and methods. 47 patients with chronic spontaneous urticaria were included into the study. All patients were divided into 3 groups depending on the therapy administrated The first group (23 patients) received the the intradermal аutoserumhistaminotherapy, the second group (15 patients) received the intradermal аutoserumtherapy, the third group (9 patients) received only the standard pharmacotherapy. The autoserumhistaminotherapy was conducted by intradermal injections of autoserum with 0,01 % histamini dihydrochloridum solution. Results. The positive effect of the аutoserumhistaminotherapy was noted in 10-14 days treatment in the statistically proven-activity urticaria decreasing and thequality of life improving in the comparison to the initial level. After a year of supervision at 57 % of patients with chronic spontaneous urticaria after a course аutoserumhistaminotherapy and at 27 % after аutoserumtherapy the proof positive posttherapeutic effect remained, in comparison with pharmacotherapy at which it was not. The conclusion. The intrademal аutoserumhistaminotherapy is a highly effective method of the treatment in patients with chronic spontaneous urticaria, it reduces symptoms of the urticaria and other medicines requirement, improves the quality of life and also allows to reach the remission of the disease.