THE MECHANISM OF DESTRUCTION OF BIOLOGICAL TISSUE AT A LOCAL CRYODESTRUCTION
The results of a study of the mechanism of primary damage, inflicted on the biological tissue (by the example of the liver) after a local cryogen destruction, are described. Such primary damage to the tissue was shown to he related with deformation effects appearing in the process of freezing-defrosting and to result in the death of microcirculation-path vessels. The ischemic tissue necrosis develops later in the cryogen impact area. The causes limiting the possibilities of the cryogen destruction of tissues were defined, i.e. density of the tissue structure and metabolism intensity predetermining a high level of thermal production and leading, in the end, to a dynamic equilibrium.