The History of Discovery and Long-Standing Applying Experience of Glucosamine Sulfate in Clinical Practice
The article discusses the current state of the problem of effectiveness and safety of osteoarthritis treatment with focus on glucosamine sulfate. There is presented the history of the discovery of the compound (including its stabilized form), based on which the drug DONA (prescription medicine of crystalline glucosamine sulfate) was created. There are indicated main parameters of pharmacokinetics, which ensure uniqueness of the preparation, demonstrate its specificity and predeterminate the effectiveness and safety. Evidences of the efficacy and safety of glucosamine sulfate and crystalline glucosamine sulfate DONA are presented in vitro and in vivo studies. In this article there is indicated a contribution of Russian scientists in evidence obtaining of efficiency and safety of DONA in the various plans of gonarthritis treatment. It is emphasized the reasonable inclusion of this drug in the ESCEO algorithm.