APPLYING OF THE "DISSOLUTION" TEST FOR A PRELIMINARY ASSESSMENT OF THE BIOEQUIVALENCE OF DRUGS OF ACETYLSALICYLIC ACID
At present, the pharmaceutical market has a huge number of drugs for the treatment of diseases of the cardiovascular system, and the greatest number of them is represented by generics. The development of inexpensive, sensitive and accurate express methods for determining the bioequivalence of drugs in various dosage forms is an urgent task of modern pharmaceutical analysis. The bioavailability of the acetylsalicylic acid was studied by an in vitro method the «Dissolution» test in this research. To determine the concentration of acetylsalicylic acid in the solutions, a method of spectrophotometry in the UV range was used. The dissolution profiles for six preparations of the Russian Federation and the CIS countries were studied. To compare the dissolution profiles, similarity coefficients were calculated. A hypothesis has been put forward on the effect of polymorphism and auxiliary substances, in particular stearic acid, on the quality and completeness of the release of acetylsalicylic acid from tableted dosage forms.