The State of the System of Lipid Peroxidation and Blood Antioxidant Protection in Patients with Various Clinical and Morphological Forms of Chronic Pancreatitis
In the development and progression of chronic pancreatitis (CP), it is important to increase the intensity of lipid peroxidation (POL) processes with inhibition of the enzymatic antioxidant defense (AOD). Purpose - to study the parameters of lipid peroxidation and antioxidant protection of blood in patients with various clinical and morphological forms of CP. Material and methods. 4 groups (120 patients) were examined: I - 12patients (10.0%) with obstructive, II - 33 (27.5%) patients with calcific, III - 42 (35.0%) patients with fibro-parenchymal, IV - 33 (27.5%) patients with CP complicated by pseudocyst. The state of the lipid peroxidation system was assessed by the concentration of malondialdehyde (MDA) in the blood plasma and erythrocytes and the level of intermediate lipid peroxidation products. The state of the AOD system was assessed by the activity of superoxide dismutase (SOD) and catalase in erythrocyte hemolysate. Plasma levels of ceruloplasmin (CP) were measured. The control group consisted of 20 healthy individuals. Results. Practically in all patients with CP (90.0%), activation of the processes of lipid peroxidation was revealed (according to the level of MDA and intermediate products), more often in patients of groups I and II (p < 0.05). In 97.4% of patients with CP, there was an imbalance between the accumulation of primary POL products and a significantly accelerated decomposition of the products of their transformation into dialdehyde products (MDA). SOD enzyme activity was significantly reduced in 31.8% of patients with CP, catalase activity was reduced in 39.5% of patients, and the activity of the extracellular enzyme CP in all patients was significantly increased. Conclusion. In patients with chronic pancreatitis, a pronounced intensification of free radical POL was established against the background of the stress of the enzymatic system of AOD. The most significant imbalance of the POL - AOD system was found in patients with a longer course of the disease.