Evaluation of biological activity of morphine, loperamide, and naloxone in the human glioblastoma T98G continuous cell line in vitro
Evaluation of the biological activity of morphine and loperamide as well as their combination with naloxone was performed in the model of the human glioblastoma T98G continuous cell line in vitro. We found that loperamide, similarly to morphine, has an agonistic effect on the m-opioid receptors, which was shown by an increased DNA synthesis in the cultured T98G cells and by a complete blocking of its action by naloxone in vitro.