MORPHOLOGICAL ASSESSMENT OF METASTATIC POTENTIAL OF PROSTATE CANCER
Close association between the presence of remote metastases, the degree of vascularization and lymphoid infiltration of the tumour tissue, the area of smooth muscles actin, cyclin Bl expression in endothelial cytoplasm, as well as the level of cyclin Dl in tumour cells cytoplasm has been revealed. The correlation of metastasis process intensity with different combinations of cyclins Bl and Dl cytoplasmic expression degree reflects the prolipherative activity and antioncogenic potential of a tumour cell.