INFLUENCE CONDITION OF NEOANGIOGENESIS AT EXPRESSION OF PROTEIN NUCLEOFOSMINUM/B23 AND ACTIVITY NUCLEOLAR APPARATUS OF RENAL CELLS CANCER
In this scientific work, authors analyzed expression nucleoli protein nucleofosminum/B23 and options of morphofunctional activity of nucleolar apparatus of neoplasm´s cells at renal-cell cancer depending on the neoangiogenesis of neoplasm. 109 resected kidneys was investigated about cancer. The following parameters was explored: the number of nucleoli per nucleus; area of nucleoli-forming zones and number of fibrillar centers, percentage ring-shaped, transitional and nucleolonemal morphofunctional variants of nucleoli per one nucleus. Expression of protein nucleofosminum/B23 and CD34 was found with immunohystochemical method. Is shown, that expression of nucleofosminum/B23 and options of nucleolar apparatus was authentically increased in cells of carcinoma with low density of microcirculary track. Hypoxia in badly-vascularized neoplasms caused hyperexpression of nucleofosminum/B23 and rising the nucleolar activity of neoplasm´s cells, it is result of progression of renal-cells cancer.