Embryonic Therapy of Vulvovaginitis in Women of Reproductive Age
The aim of the study is to evaluate the effectiveness of empirical therapy of acute vulvovaginitis using a modern combination drug with antimicrobial, antifungal and anti-inflammatory effects. Material and methods. The study was carried out in 2019-2020 at the clinical base of the Department of Obstetrics and Gynecology of the Novosibirsk State Medical University of the Russian Ministry of Health. Divided into two representative groups. On the basis of complaints, clinical symptoms and objective examination, patients were prescribed empirical therapy with the complex antimicrobial drug Gainomax. In the first group of 1 suppository once a day for 7 days vaginally and in the second group of 1 suppository twice a day vaginally for 3 days. We conducted a gynecological examination, pH-metro, bacterioscopic and bacteriological examination of vaginal fluid (Femoflore-16), assessed the dynamics of clinical symptoms. Results. In the first and second groups, there was a complete disappearance of unpleasant smell - 91.7 and 88.9%, feel of itching and burning in the vagina - 91.7 and 94.4% of patients, respectively. Found a three-fold increase in the detection frequency of Lactobacillus spp. with a degree of contamination of 10<sup>6</sup>-10<sup>7</sup> CFU/ml in the first and second groups, suppression of the concentrations of obligate-anaerobic representatives by 8 and 7 times, respectively (associations of Gardnerella vaginalis + Prevotella bivia + Porphyromonas spp., and Eubacterium spp.), facultative anaerobic bacteria (Enterobacteriaceae and Streptococcus spp.) by 5.5 and 5 times, respectively. Yeast-like fungi of the genus Candida were not identified in the groups. Conclusion. The study demonstrated in the first and second groups a high clinical 100 and 100% respectively and microbiological 94.1 and 93.8%, respectively, the effectiveness of empirical therapy Gainomax in 72 women of reproductive age with acute vulvovaginitis.