Indoor treatment results in pulmonary multi-drug resistance tuberculosis patients
To estimate indoor treatment efficacy in pulmonary multi-drug resistance (MDR) tuberculosis patients, 481 medical histories of patients with pulmonary tuberculosis treated at Novosibirsk Research Institute of Tuberculosis in 2014-2016 were analyzed. The group included 246 incident patients, 95 patients admitted with recurring pulmonary tuberculosis, and 140 due to the chronic course of the disease. Bacterial excretion was observed in at least 96.4 % cases, with drug resistance (DR) of M. tuberculosis was detected in 94.0-100 % patients. The detection rate of multiple DR reached 80.5 % and broad DR 29.3 %. The average time of cessation of bacterial excretion defined using fluorescent microscopy was 3.2 months and for bacterial inoculation method 4.5 months. The average time of cavity closure was 5.5 months. Thus, the amount of incident patients in 2016 was 48.3 %, and chronic course of the disease was recognized in 32.8 %. In 2016, cessation of bacterial excretion in incident patients defined using fluorescent microscopy was 91.7 % and for bacterial inoculation method 88.6 %; the values for the chronic course of the disease were 60 and 47.8 % respectively.