THE FEATURES OF PATHOGENESIS OF AN ANEMIC CARDIOMYOPATHY IN PATIENTS WITH CHRONIC IRON DEFICIENCY ANEMIA IN ZABAIKALYE
The purpose of the lecture was to elucidate the basic of pathogenic mechanisms of an anemic cardiomyopathy. The cardiomyopathy was observed in patients with chronic iron deficiency anemia and was characterized by development of segmental diastolic dysfunction in many segments of the left ventricle and hyperkinetic type of central hemodynamic with subsequent formation of the global diastolic dysfunction of the ventricles and hypertrophy of the left ventricle. The metabolic disorders of blood lipids, increased level of lipid peroxidation products, significant reduction of antioxidant enzymes activity, reduction of blood selenium, imbalance of energy phosphates and increased production of proinflammatory cytokines has an important role in pathogenesis of the anemic cardiomyopathy.