Indicator values in laboratory diagnosis of babesiosis
Problem of babesiosis attracts a lot of attention in the last decade, because not only animals, but people are getting ill with babesiosis in our days also. Babesiosis (piroplasmosis) is a natural focal vector-borne blood protozoan disease caused by animalculine microorganisms of Babesia genus. In a basis of babesiosis pathogenesis lies pathophysiological process associated with generalized inflammatory response to pyrogenic of Babesia substances that enters bloodstream with destruction of red blood cells. There is not enough factual evidence in scientific literature to date, that allows to understand uniquely which of laboratory tests parameters are most informative in case of babesiosis. Babesiosis is a rapidly evolving disease that requires not only an identification of Babesia in erythrocytes, but immediate assessment of pathological process severity. The goal of this work was to evaluate informativity of diagnostic laboratory data of dogs with babesiosis and to identify indicative among them. Screening of informativity of diagnostic criteria for dogs babesiosis allowed to refer the following characteristics to the number of urine indicative data: coloring, presence of gemoglobinurii, “shadows of red blood cells" in large numbers, presence of kidney epithelium cells; to the number of highly informative in assessing of pathological process severity: protein content, presence of ketone bodies at zero glucose level, white blood cell count. In laboratory studies of blood, level of red blood cells can be categorized as one of indicative parameters. Pairwise correlation of urea and blood creatinine levels is a highly informative parameter for assessing disease severity that helps to evaluate degree of development of kidney pathology. Indicative and highly informative diseases parameters fully reflected the degree of development of pathological process and severity of babesiosis. The article is based on large amount of experimental data. Studies involved more than 80 dogs ill with babesiosis from 4 age categories. It was established that the disease is the most debilitating for older dogs and dogs younger than 2 years. These two groups require the most focused attention in babesiosis treatment.