THE EFFECTS OF ALCOHOL INTOXICATION DURATION ON AMINO ACIDS POOL IN BLOOD PLASMA
In the present study, a comparative analysis of the amino acids (AA) pool in blood plasma of rats undergoing various modes of alcohol exposure was performed. It was found that the pattern and severity of amino acid imbalance depend on the duration of alcohol intoxication. Chronic alcohol intoxication resulted in increased blood plasma levels of tyrosine and decreased concentrations of glycine, methionine, and histidine and also reduced the ratio of branched-chain amino acids to aromatic amino acids. In the group of animals undergoing subchronic alcohol intoxication the blood plasma levels of alanine, tryptophan and proline were elevated and there was a growing proportion of interchangeable and glycogen amino acids in the common pool.