PREVENTION IN OF DELIRIUM IN CARDIAC SURGERY
Studied 519 patients after coronary bypass operation. Patients were divided into two groups. In group I (n = 323) was used perioperatively dexmedetomidine. Introduction of the preparation (loading dose of 1 mg / kg over 20 minutes) after the administration started and continued infusion of anesthetic (0.2-0.4 mg / kg / hour) at all stages of the operation in the next few hours after the operation. Total time of drug administration was 18-24 hours. In group II (n = 196) using the standard drugs for general anesthesia and postoperative sedation. It was found that the use of dexmedetomidine decreased the frequency of delirium from 9.2% to 2.8% (p < 0.05). Against the background of the infusion of dexmedetomidine reduced the need to use morphine. The frequency of administration of morphine in group I was 17.6% in patients of group II preparation was used in 42.3% of cases (p <0.05). Inclusion of dexmedetomidine in a comprehensive program of pharmacological treatment of delirium caused a shortening of the duration of delirium flow from 3,24 ± 1,6 to 1,6 ± 0,7 days (p <0.05) decrease in doses used haloperidol and reduced use of mechanical ventilation (mechanical ventilation rate I group - 50% in group II - 83.3%, p < 0.05).