Role of dysfunction of neuroendocrinal system of the organizm of the woman in formation of the pathology of mammary glands on the background of the hysteromyoma
The purpose of research. to define affection of dysfunction of autonomic nervous and endocrine system, common adaptation reactions of an organism of the Woman in realization of combination pathology uterus and mammary glands. Materials and methods. It was examined 46 women with a hysteromyoma and fibro-cystic disease of mammary glands, at the age 45,5±2?1 y.o. It was explored clinical data, levels of gonadotropic and steroid hormones, the condition of vegetative nervous system by the method of cardiointervalography on the installation «electrocardiogram-trigger». Results. Hypersympaticotonic vegetative reactivity and superfluous vegetative maintenance, and also a strain of the general adaptation reactions testifies about chronic subcompensation and explains a new level of adaptation of an organism. Secretion of gonadotropic hormones at the given level of disease, remains at a normal level. However, it was diagnosed of depression estrogen and progesteronum of production function of ovaries (oestradiolum 133,8±33,0 in an examining group against 275,0±14,9 Рmоl/l in the control and progesteron 9,45±1,9 against 20,5±5,6 ng/l, р<0,05), that promotes the beginning of pathology mechanisms, which realizes the diseases. Conclusion. Intention of adaptation reactions of an organism at the subcompensation level in combination with disgormonemia and disfunction of vegetative nerves system in women with myoma of the utery lead to formation fibro-cystic disease of an overage degree of gravity, mainly with prevalence of cystic component. Earlier revealing and research of ways of elimination of the disturbed functional mutual relations and risk factors, retention transformation to clinical form of disease