MORPHOFUNCTIONAL CHARACTERISTICS OF SP-POSITIVE STRUCTURES OF THE THYMUS OF LABORATORY RATS IN THE PREPARATION OF CALCIUM WITH DRINKING WATER
A long-term intake of calcium with drinking water into the structure of the thymus of laboratory rats was studied. With the help of immunohistochemical and statistical methods, SP-positive structures of the thymus were studied in 80 laboratory rats. Morphological changes in the thymus testify to the selective nature of the action of calcium salts on SP-positive structures. It was found that prolonged intake of calcium with drinking water (235 mg / L for 60 days) leads to an increase in the number of SP-positive cells in the cortex and on the border of the cortical and medulla of the thymus lobules, to a decrease in the size and area of ​​the cells in the cortex Lobules. An analysis of the data obtained showed that the intake of calcium compounds in laboratory rats with drinking water increases the expression of SP receptors by thymus cells. Our research results showed adaptive changes in the structure of the thymus lobes to calcium salt intake and increased proliferation and differentiation of thymocytes. Identified morphological changes SP-positive cells reflect the manifestation of the adaptation reactions of the thymus to the action of calcium salts.