Lung ossification in miner: anthracosilicos or a case of rare lung disease?
The article covers the authors' own observation of lung ossification in miner and immune histochemical study of pulmonary tissue sampling for epithelial mesenchymal transformation. Pulmonary fibrosis area development, bone tissue location mostly in these area, periossal location of coal dust and heterotopic character of ossification as a possible excessive morphogenetic cellular fibroblastic reaction specific for pneumoconiosis could be arguments pro ossification as anthracosilicosis manifestation. Bronchial epithelium and pulmonary fibrosis area demonstrated vimentine as a marker of low differentiated state of mesenchymal cells - that points to anthrasilicosis association with specialized bronchial epithelium cells with changed phenotype.