Evaluation of the effi ciency of the activity of the register of potential donors of hematopoietic stem cells
Introduction. One of the problems in providing Russian transplant clinics with unrelated hematopoietic steam cells (HSCs) is the lack of an interaction scheme “Registry - HSC collection center - Transplant center”. In order to ensure effective operation at the donor activation stage, registries need regulated and stable cooperation with the Collection center with a clear distribution of duties and responsibilities for both parties. Aim: to evaluate the effectiveness of the Kirov Registry.Materials and methods. Since 2009, the Kirov Registry has been systematically working with HSC donors (as of 25/11/2019, the total number of donors was 46,922, of which 43 % male, 57 % female; 49 % regular blood donors, 51 % volunteers from donor actions) since 2013. The Registry has its own Collection Center. The effectiveness of the Registry was evaluated by indicators: the number of donations, donor activation time, the number of refusals at the stages of preliminary activation and donation of cellular material. Results. As of 25/11/2019, more than 1,000 preliminary activations of potential HSC donors were performed, of which 175 were completed by collection of HSCs. The use of the created and validated activation model with the employment of the Registry and the Collection Center currently provides the following activation times: the period for sending a sample for confi rming HLA typing does not exceed 14 days; the total time to satisfy the transplant center request for cellular material does not exceed 2 months. A detailed analysis of the causes of refusals at the stages of preliminary activation and after receiving a request for the collection of cell material was carried out. Conclusion. Between 2009 and 2019 the Kirov registry has developed a model of effective work with the donors of the HSCs at all stages of the chain “Registry - HSC collection center - Transplant center”. The effectiveness of the work is confi rmed by the demand for donors, observance of the donor activation time, and a relatively low percentage of refusals from donations.