ENZYMES OF PURINE METABOLISM IN BLOOD LYMPHOCYTES AT THE WPPT-FERENTIAL RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS AT EARLIER STAGES OF THE DISEASE
In lysates of lymphocytes of 55 patients with rheumatoid arthritis (RA) with the duration of the disease is not more than 1 year and 57 patients with osteoarthritis (OA) with the duration of the disease up to 2 years to determine the activity of adenosine deaminase (ADA), AMP deaminase (AMFDA) adenindezaminazy (BP) 5’-nucleotidase (5’-NT). Studies have shown there that in patients with RA compared with healthy lymphocytes lysates higher activity of ADA AMFDA, 5’-NT activity and lower blood pressure. Patients with OA in lysates lymphocyte activity higher blood pressure. Reveals some activity relationship of enzymes in lymphocytes depending on the degree of activity of the process in RA patients and of synovitis in patients with OA. Comparative studies have shown that in patients with OA, compared to patients with RA activity in lymphocytes below ADA AMFDA, 5’-NT and higher blood pressure. Similar differences in the enzyme complex with clinical and instrumental data, taking into account the yield of enzyme activity for the reference limits of healthy individuals, the maximum and minimum values ​​of the enzyme activity, promote differentiation Diseases studied in the early stages of the disease.