SEARCH RESULTS FOR LUBRICANT FORMS OF BIOACTIVATED ANTIOXIDANT N-ACETYLCARNOSINE FOR OPHTHALMIC USE: PECULIARITIES OF DOSE-DEPENDENT DELIVERY TO THE EYE
The problems of pharmacology and pharmacokinetics of bioactivated antioxidant N-acetylcarnosine (NAC) are considered. NAC is intended for the treatment of a range of ophthalmic disorders related to aging processes, oxidative stress and glycosylation. The prodrug form includes 1% solution of NAC, L-isoform of dipeptide manufactured according GMP technology, lubricant carboxymethylcellulose and promoters, facilitate the dipeptide penetration to the aqueous humor. Ophthalmological use of 1% NAC lubricant drops (Can-C TM, ClarastillTM) is directed to clinical optimization of the L-isoform of dipeptide application for the treatment of eye diseases. / Russian Ophthalmological Journal, 2009; 4:43-47.