Manifestations of endogenous intoxication in acute pancreatitisassociated lung damage in experimental Cytoflavin correction
The experiment simulated acute pancreatitis in rats by two intraperitoneal injections of 20% L-arginine (total dose of 5 g/kg, with an interval of one hour) by the method of L. Czako. In the control group of animals within 5 min after simulation of acute pancreatitis injected drug «Cytoflavin» in a dose of 0.21 ml/kg body weight. We determined amylase activity, MM254 and MM280 rate, the level of malonic aldehyde, diene conjugates in blood, lung and pancreas tissue were examined histologically. In experimental acute pancreatitis indicators of endogenous intoxication signifi cantly increased in12–48 h, that is directly dependent on the severity of membrane destruction processes in the tissues of the pancreas against the growing activity of lipid peroxidation. Use of the drug «Cytofl avin» reduces the severity of endotoxemia: reducing MM – in 24 h and 72 h, malonic aldehyde and diene conjugates – after 24 hours. It also has a positive impact on the protective components of aerohematic barriers and reduces their acute pancreatitis-associated lung damage in the experiment decreasing oedema of interalveolar barriers and improving microcirculation.