Impact of Valprazolamide on the Exploratory Behavior in Mice
The effect of valprazolamide, a new antiepileptic agent from the group of amide derivatives of valproic acid, on the exploratory behavior of mice in “open field” test and a “dark/light transition” test was studied. As a result of the experiment, it was revealed that the new antiepileptic drug valprazolamide, when used in doses of 75 mg/kg and 150 mg/kg, hadn’t a significant effect on the orienting-exploratory behavior of mice. With a single intraperitoneal injection at a dose of 300 mg/kg, individual manifestations of rodent research activity increased (horizontal locomotor activity when tested in the open field), and at a dose of 450 mg / kg, it had a depressing effect on the orientation reflexes in rodents.