THE LIPID PROFILE AND SYSTEMIC INFLAMMATION RESPONSE INDICES IN PREECLAMPSIA WITH EARLY AND LATE ONSET
Goal of research: the estimation of lipid profile and systemic inflammation response indices in preeclampsia with early and late onset. In case-control study there were 57 women with late preeclampsia (with manifestation after 34 weeks of pregnancy) and 26 patients with early preeclampsia. We have studied the characteristics of anamnesis, outcomes of gestation and labor, lipid profile indices and systemic inflammation response markers (high sensitivity C-reactive protein – hsCRP, Kalf-Kalif index leucocyte index of intoxication). As a result of our studywe haven’t found any association of late preeclampsia with “maternal investment” (metabolic syndrome, chronic arterial hypertension, kidney disease).The increased levels of proinflammatory lipid profile indices (triglycerids, very low density lipoproteins, atherogenic index) and of inflammation response marker hsCRP were revealed in early preeclampsia, in late preeclampsia there was the increase of leucocyte index of intoxication.The findings of our study indicate to systemic inflammation participation in pathogenesis of not only late but also early preeclampsia formation.