Metabolic Features of Patients with Late Manifestation of Preeclampsia
Preeclampsia (PE) continues to be the leading cause of maternal and perinatal morbidity and mortality. Modern data on the pathogenesis of this disease demonstrate the need and usefulness of classification based not only on the severity, but also on the timing of beginning of its clinical manifestations. The article describes a prospective study aimed at elucidating the features of the «metabolic portrait» of a patient with preeclampsia and the significance of biochemical markers (TNF and PIGF) in the development of PE forms with late manifestation, and presents its results. The level of fasting glucose, glycated hemoglobin (HbA), tumor necrosis factors (TNF) and placental growth factors (PIGF) at 11 weeks, carbohydrate tolerance test (TTT) with 75 g of glucose at 24-28 weeks have been studied.