THERMOGRAVIMETRIC INVESTIGATIONS OF VAGINAL SUPPOSITORY WITH THYME OIL
Methods and results. On the grounds of carried out derivatographic investigations it has been established that thermal treatment of hydrophilic suppository base of vaginal suppository with thyme oil at the temperatures which are used during suppository making (70-80º) doesn’t lead to its components destruction. Moreover, it has been determined that developed vaginal dosage form with thyme oil - suppository on the hydrophilic base - is a mechanical mixture of active substances and excipients because its components doesn’t interact each other.Conclusion. Appropriate adding of thyme oil to the suppository base must be done at the 52-53ºС with instant pouring in the form and immediate cooling.