Content of metallothioneins in liver and kidneys of rats of different age at intra-abdominal administration of cadmium nitrate
Significant differences were found out in the content of metallothioneins and cadmium in liver and kidneys of rats of different age at the intra-abdominal administration of cadmium nitrate solution in doses of 0.5 and 2 mg/kg in terms of metal ions. In 60 week aged animals a lower level of metallothioneins was revealed in animal organs than in 40 week aged but the content of cadmium was higher. With increased exposure doses, this discrepancy exacerbated. It is supposed that high doses metal exposure evokes dampening of the compensatory and protective potential of the organism with aging. Материал поступил в