EFFECTS OF MULTIPLY MODIFIED LOW DENSITY LIPOPROTEINS ON HEMODYNAMIC INDICES IN RATS
It is generally accepted that multiply modified low density lipoproteins (mLDL), as physiological metabolites of oxidative stress, are the main factors in the development of endothelial dysfunction in atherosclerosis. The purpose of this study is to study the acute effects of administration mLDL on hemodynamic parameters (blood pressure, heart rate) in rats. The obtained data on the dynamics of hemodynamic parameters after a single intraperitoneal injection of mLDL have shown that this action induces acute vascular dystonia according to the hypotensive type and can be used as a method for its modeling.