FREQUENCY OF EXPRESSION OF HLA SYSTEM ANTIGENS IN PATIENTS WITH RECURRENT HERPESIS INFECTION
Currently, the following HLA-associated diseases as: ankylosing spondylitis (Bechterew’s disease), Reiter’s syndrome, rheumatoid arthritis, acute anterior uveitis, celiac disease, Addison’s disease, diffuse toxic goiter, insulin-dependent diabetes mellitus (DM) and others. In addition, the dependence of the course of the disease on the HLA – genotype is observed for some diseases. The study of genetic mechanisms controlling the resistance of the immune response to various infectious diseases becomes one of the most important sections of infectious immunology. Recurrent forms of herpes-virus infection (RHI) are found, according to different authors, in 5-30 % of people of working age. Their development is directly related to the violation of cellular and humoral mechanisms of immunological resistance, in particular, in the HLA system. The obtained results on the distribution of HLA antigens in RHI patients allowed to determine antigens and antigen groups among all three studied loci having either positive or negative association with this pathology. Of the most significant antigens with a positive association in the development of the RHI, mention should be made of HLA-A3 (Pc <0.01), (Pc <0.01). The combination of these HLA antigens in patients with herpes infection is probably the determining factor in the mechanisms of genetic predisposition and resistance of individuals to the development of the RHI.