SOME ASPECTS OF NNITROSOCOMPOUNDS` BIOTRANSFORMATION
Aliphatic and heterocyclic amines represent a large class of physiologically active substances of natural and synthetic origin. Many of them can be transformed in to the body under certain conditions, causing carcinogenic, mutagenic and teratogenic effects. On the other hand, because of their reactivity, they are prospective objects for designing dosage forms, including macromolecular therapeutic systems. At the same time their metabolism, pharmacokinetics, pharmacodynamics and organotropism are almost not analyzed.