INFLUENCE OF FLUORIDE INTOXICATION ON NITRIC OXIDE PRODUCTION IN BLOOD AND GASTRIC MUCOSA OF RATS
Article deals with the effect of chronic fluoride intoxication on the production of nitric oxide in the blood and mucous membrane of the stomach of rats. It was established that chronic fluoride intoxication increases the production of nitric oxide by NOS- mediated pathway. Activation of tissue nitrite reductases in conditions of excess intake of fluoride ions is an adaptive reaction aimed at reducing the concentration of nitrites in tissues.