Disturbances of tissue respiration and mitochondrial lymphocyte dehydrogenase s activityin acute poisoning by neurotropic substances
The study of tissue metabolism (28 patients) and mitochondrial dehydrogenase activity of the lymphocytes (21 patients) in acute neurotropic poisoning in the early period was conducted. The role of tissue hypoxia in the activation of mitochondrial enzymes, mainly succinate dehydrogenase, during the first 6 hours with their following exhaustion in case of ineffective correction of toxicohypoxic states was reported. There was made an attempt to consider these changes as one of the adapted metabolic reactions in tissue hypoxia from the standpoint of new data.