Role of genes polymorphisms of the second phase of detoxification for unexplained infertility
The aim of the work was the possible association of polymorphic variants of detoxification genes of the second phase (EPHX1, GSTP1, TMTP) with unexplained infertility. The study involved 150 women. 100 women with a diagnosis of "unexplained infertility” the main group and 50 women who did not suffer from infertility, a control group. Shown significant differences in the studied polymorphic variants of genes between the study and control group. These results suggest an association with the development of detoxification genes pathology and suggest an important role of detoxification system in the genesis of reproductive disorders.