Molecular-biological mechanisms of interconnection between hypoxia, inflammatory and immune reactions
The review is devoted to the molecular-biological mechanisms of the connection between hypoxia, inflammatory and immune processes, since it is known that lack of oxygen, on the one hand, can initiate the development of inflammation, and on the other, any inflammatory process, especially with severe systemic symptoms, is accompanied by lack of oxygen. The review provides current approaches to the connection between key transcription factor that is activated during hypoxia, HIF-1a, with the nuclear factor NF-kB, regulating inflammation. Literature data on the role in inflammation of HIF-1 a activation in various types of cells and tissues, which can have both anti-inflammatory and pro-inflammatory effects, are generalized. The study of the connection between the molecular-biological mechanisms of inflammatory and immune responses and hypoxia is important not only for understanding the effects of HIF-1 on NF-kB, but also for creating potentially new therapeutic approaches to the treatment of inflammatory diseases and tumors, since HIF-1 plays an important role in their development.