Synthesis and Biological Activity of Sulfamide-Containing Carboxyl Esters of Nicotinic Acid
The esterification reaction of nicotinic acid and the reaction products of chloramine-B with allyl chloride and acrylonitrile was investigated. High reactivity of chlorine atoms was found in N-2-chlorosulfonamidopropanol and in N-2-chlorosulfamidocyanoethane. Under the influence of the electron-withdrawing sulfamide group, the nitrile group in 1-carboxypyridin-2-benzenesulfamido-2-cyanoethane easily reacts to heterocyclization with polarophiles, forming pyrrole derivatives and pyridine. The study of the antimicrobial properties of the synthesized esters has shown their high efficiency