Multidimensional Complexity of Cancer: Simple Solutions are Needed (review)
Cancer is a complex system. Tumor complexity is determined not only by genetic and epigenetic heterogeneity, but also by a huge number of interactions between cancer and normal cells. The heterogeneity and complexity of the tumor determine the failure of molecular targeting therapy as a tool for fighting cancer. This review considers concepts of cancerous tumors as entities that have common characteristics despite all heterogeneity. It leads to the idea that the most promising strategy for fighting cancer is the use of the patient’s immune system.