EFFECT OF METABOLIC ACIDOSIS ON THE STATE OF THE VASCULAR-PLATELET HEMOSTASIS, BLOOD COAGULATION AND FIBRINOLYSIS
The article is devoted to the investigation of effect of lactic acid on the performance hemocoagulation hemostasis. Metabolic acidosis, caused in the experiment on 42 animals (cats) by intravenous injection 3 % a lactate acid in up to a pH level 7,25-6,8, and duration up to 30-180 min. Lactic acidosis leads to increased permanent intravascular coagulation. At pH 7,25 - 7,15 hypercoagulation and partial consumption of fibrinogen and factors of blood coagulation are observed, which was confirmed by thromboelastography and elektrokoagu-lograpy. The pH shift up to 7,07 - 6,9 is accompanied by coagulopathy of consumption, significant decrease of a level fibrinogen and sharp increase of fibrin degradation products, thus lengthening the main parameters and reduced amplitude thromboelastogram. All these changes are indicative of the occurrence of a fibrin clot is very low elasticity