Immunotherapy of Metastatic Melanoma Yesterday, Today, Tomorrow
For a long time, the main drug for the treatment of patients with metastatic melanoma remained dacarbazine, approved by the US Food and Drug Administration in 1975. This method of treatment could hardly guarantee the significant increase in overall survival. Taking in account the high immunogenicity of melanoma, back in the XIX and XX centuries, scientists began to develop immuno-oncological drugs aimed at activating antitumor immunity. Many studies were conducted before the goal was achieved. So in the arsenal of an oncologist there appeared check-point inhibitors - which are in fact the most effective method of treating melanoma, which radically changed the prognosis of the disease.