ANALYSIS OF LOCAL AND GENERAL IMMUNITY AT THE ODONTOPREPARATION
Odontopreparation is a traumatic intervention at the organ/tissue level and the entire body, which certainly affects the immune resistance and local immunity. Local protection system includes oral mucosal epithelium, saliva, and gingival fluid. The diagnostic and prognostic values of the concentration of secretory immunoglobulin A, IgG, immunoglobulin M, E, D, contents of polymorphonuclear neutrophils, macrophages, T-helper cells (CD4+), levels of cytokines (tumor necrosis factor-?, IL-2, IL-4, IL-6, ?-interferon, IL-1, TNF, IL-6, chemokines), and markers of CD3+, CD4+, CD8+, CD4+/CD8 +, CD19+ in saliva, gingival fluid and blood in inflammatory processes in the oral cavity and during odontopreparation are discussed. These studies provide an opportunity to evaluate and predict the severity of the pathological process, and to formulate some basic criteria for assessing the degree of disturbances of immune status in patients after orthopedic treatment carried out.