THE ROLE OF NATURAL SELECTION IN THE FORMATIONOF THE GENETIC STRUCTURE OF POPULATIONS BY SNP MARKERSIN ASSOCIATION WITH BODY MASS INDEX AND OBESITY
Obesity becomes one of the global problems in modern society, provided that more than a third of the world’s population suffer from overweight. This phenotype affects the quality of life and is associated with cardiovascular diseases, diabetes, cancer and reproductive disorders. The population variability of allele frequencies of 26 single nucleotide polymorphisms, in association with obesity and body mass index according to the data of genome-wide association studies (GWASs) is discussed in this study. The genetic variability was analyzed in populations of Northern Eurasia and populations from the human genome diversity project (HGDP). The studied population samples are characterized by high genetic diversity that correlates with climatic and geographical parameters. The results of the test for searching natural selection signals in total revealed the selection effect for the rs1167827 of the HIP1 gene, rs7138803 and rs7164727, located in the intergenic region, rs7141420 of the NRXN3 gene, rs7498665 of the SH2B1 gene, rs7903146 of the TCF7L2 gene.