Clinical and functional features of the upper gastrointestinal tract in children with chronic gastroduodenitis in 3 and 6 months after eradication therapy
We studied the morphological and functional features of the stomach and duodenum in children with chronic gastroduodenitis (CGD) associated with Helicobacter pylori infection in 3 and 6 months after successful eradication therapy. Initially we carried out examination of 155 children with CGD associated with Helicobacter pylori (HP)-infection in the acute phase of the disease. In the following we examined 100 children in 3 and 6 months after the proven eradication of HP. We found that manifestations of abdominal pain syndrome was significantly decreased (100% in the acute stage versus 7% and 5% at 3 and 6 months after eradication, p < 0.01). At the same time, almost 30% of children still had symptoms of intestinal dyspepsia (31% and 36% of children after 3 and 6 months) in the form of rumbling along the colon and changes in stool. The morphological changes in the stomach and duodenum preserved in 37% of cases: was present lymphoplasmocytic infiltration of gastric mucous and atrophy in 9%. These changes were positively correlated with the identification of CagA factor. Changes in the motor-evacuation function of the stomach were characterized by disturbances in the anthro-duodenal regulation in 25% of children and positively correlated with disorders of acid-neutralizing function.