ADMINISTRATION OF HEMOPOEITIC GROWTH FACTORS AFTER HIGH-DOSE CHEMOTHERAPY ACCOMPANIED BY AUTOLOGOUS HEMOPOEITIC CELLS TRANSPLANTATION
Objective. To study efficiency of the combined administration of erythropoietin (EPO) and granulocytic colony stimulating factor (G-CSF) as compared with the G-CSF isolated administration in patients with various hematologic diseases, breast cancer, multiple sclerosis having undergone high-dose chemotherapy (HCT). Materials and methods. Ninety nine patients divided into two groups were involved in the study. The patients in the 1st group received G-CSF during the early postoperative period, those in the 2nd group were administered EPO in combination with G-CSF. The peripheral blood values were controlled. The patients were transfused erythrocyte mass and platelet concentrate. Results. Administration of EPO in combination with G-CSF after HCT and autologous hemopoeitic cells transplantation resulted in the hematologic toxicity reduction when compared with the G-CSF monotherapy. The terms of the hemoglobin, platelet, leukocyte, and neutrophil levels were smaller in that group as well.