DEVELOPMENT OF THE COMPOSITION AND TECHNOLOGY OF A SOLID DOSAGE FORM WITH THE ANTI-ULCER ACTION. Report 1
According to the literature data and experimental studies the optimal composition of the drug with the anti-ulcer action developed on the basis of standardized biologically active substances of bee products and products of the plant origin, which have specific chemical and pharmacological properties for a new domestic, natural, highly effective drug, has been suggested. To solve this problem a new domestic biologically active substance - powdered natural honey (PNH), propolis phenolic hydrophobic drug (PPHD) and “Plantaglucid” granules will be used. By the technological, pharmacological, physicochemical, chemical and biopharmaceutical properties all of them refer to the substances for creating a new drug in compliance with its purposeful activity. The corresponding scientific and technical documentation that meets the requirements of the State Pharmacopoeia of Ukraine (SPhU), namely PNH (TU U 15.8 - 02010936 - 001:2007); PPHD (UA/4505/01/01 the order of the Ministry of Public health of Ukraine No. 289 of 18.05.06); “Plantaglucid” granules (register No. UA/4695/01/01, the order of the Ministry of Public health of Ukraine No.83 of 14.02.11) has been developed and approved for initial substances. The formulation to be developed will be created as a solid dosage form (granules, capsules, suppositories), as a drug for treating peptic ulcer disease of the gastrointestinal tract (GIT).