FOR CANCER OF THE MOUTH WITH REGARD ASSOCIATION WITH THE EPSTEIN-BARR VIRUS, HUMAN PAPILLOMAVIRUS AND THE LEVELS OF CERTAIN CYTOKINES
Studies of patients with cancer of the oral cavity with regional metastases and without them showed a 2–3 fold predominance of IL-1, IL-6, IL-8, in the tumor tissue compared to peritumoral area (p < 0,05) which can be connected with their production by tumor cells and the presence in the tumor tissue virus, Epstein-Barr virus and human papillomavirus. No significant differences between the local levels of the cytokine (IL-2, IL-8, IL-6, IL-10, IL-1β, IL1RA, IFN-α, IFN-γ, TNF-α) in groups of patients with metastases, and without metastases was not detected, this can be attributed to nonspecific reactions viruses. In patients with cancer of the oral cavity without metastases was observed in the prevalence of tumor tissues of human papillomavirus (73.3 %) compared with patients who have regional metastases, which dominated the Epstein-Barr virus (70 %). Received laboratory and clinical data led to the conclusion of a favorable disease course and prognosis in HPV-positive patients in comparison with EBV-positive patients.