Status of connective tissue and cancer of mammaria gland: morphological and immunohistochemical aspects
Cancer of mammary gland — the most frequently tumor in women, especially those older than 50 years. Annually from the disease kills about 500 thousand women, accounting for more than 15% of all cancer deaths. Necessary to carry out the search for new approaches to the diagnosis of breast cancer. The purpose of the study — to evaluate the morphological features of the growth of breast cancer and some immunohistochemical parameters depending on the constitutionally — hereditary phenotypic characteristics of patients. Materials and methods. A total of 148 working-age women with established breast cancer treated at the Department of chemotherapeutic Stavropol Clinical Oncology Center, which are divided into three groups according to the severity of stigmas. Age 32 to 54. Phenotypic analysis was performed, complete a special examination, surgery followed by histological and immunohistochemical study. Results. The results of morphological studies have shown a definite relationship to the different forms of breast cancer phenotype manifestations. In the group of patients with non-specific signs of inherited disorders of connective tissue, invasive cancers — infiltrative ductal and lobular infiltrative — were more frequently, and some form of non-invasive, however, less likely than women with a normal phenotype. Differences also recorded on biological parameters such as hormone positive tumors and expression of markers of proliferative activity HER-2/neu and Ki-67. Conclusion. Among women of working age with signs of inherited disorders of connective tissue, more common forms of breast cancer, more severe compared with the patients — carriers of the unchanged phenotype.