MODERN ASPECTS OF THE USE OF CHOLECALCIFEROL (VITAMIN D3) AND PROSPECTS OF THE DEVELOPMENT OF SOLID DOSAGE FORMS BASED ON IT
Data on the biological and physiological role of vitamin D3 have changed significantly over the past 30 years. It became known about its significant impact on fertility of both men and women. We have studied the current data on pharmacological effects and optimal doses, the range of dosage forms of vitamin D3. The analysis showed that the composition of drugs of vitamin D3, permitted for use in the Russian Federation, include: cholecalciferol, alfacalcidol, paricalcitol, calcitriol. Only three drugs of foreign production contain a medical dose of vitamin D for women: Akvadetrim, Vigantol, D3-droplet, therefore, the development of domestic drug is relevant. Only 50 % of the oral dose of vitamin D3 is absorbed in metabolic disorders. We have confirmed the need to create a new solid dosage form of vitamin D3 with a concentration of cholecalciferol of at least 3000 IU. For its production we suggest using the cyclodextrin and mannitol (Parteck HPB and Parteck M, “Merck KGaA”, Germany). They can ensure the stability of the drug in the body and its good digestibility. Vitamin D3 tablets, coated with an intestinal-soluble shell will be convenient for use, stable during storage, provide the necessary pharmacological effect. Such dosage form can be an alternative to the already known imported drugs.