USE OF MIFEPRISTONE IN WOMEN WITH ANTENATAL DISCHARGE OF AMNIOTIC FLUID AND PRETERM PREGNANCY
Aim: To assess the efficacy of mifepristone for preparing cervix for childbirth in women with antenatal discharge of amniotic fluid (ADAF) and preterm pregnancy. Materials and Methods: We recruited 30 consecutive women at gestational age from 25 to 34 weeks with ADAF and randomly divided them into two groups, with and without administration of mifepristone for preparing cervix for childbirth. We then evaluated risk factors of premature birth and further perinatal outcomes. Results: We found that the frequency of labor dystocia was 40% (6/15 patients) and 6.67% (1/15 patients) among women who received and did not receive mifepristone, respectively. However, there were no significant differences regarding neonatal respiratory distress syndrome or hospital stay. Conclusions: Administration of mifepristone increases risk of labor dystocia but has no impact on perinatal outcomes.