1,2,4-Triazole-Based Hybrid Hydrazones of Some Heterocyclic Aldehydes and Their Influence on the Level of DNA Methylation
Hybridization is emerged as a promising strategy in the discovery of new drugs. In the present investigationa series of new hybrid hydrazones (azometines) of farmacologicaly active heterocyclic aldehydes were synthesized on the basic of 1,2,4-triazole bearing benzofuran and 5-methylbenzofuran moiety, and characterized by analytical and spectral (IR, NMR <sup>1</sup>H, <sup>13</sup>C) data. The newly synthesized compounds were evaluated for their in vitro influence on the level of DNA methylation. It has been found that some of tested compounds showed significant inhibitory activity.