EXPERIMENTAL STUDY OF THE ANALGESIC ACTIVITY OF ACONITUM KUZNEZOFFI REICHENB
One of the urgent problems of modern pharmacology is the development of high-efficiency low-dose analgesics. Promising direction is the development of drugs based on the diterpene alkaloids produced by Ranunculaceous family plants. Methods. For the experimental study of the analgesic activity of a standardized alkaloid-containing aconite extract (Aconitum Kuznezoffi Reichenb. - Ranunculaceae Juss.) the researchers used screening models of thermic (Hot plate) and chemical (Abdominal constriction test) impact of pain. Results. In the test “hot plate” there was revealed a pronounced analgesic effect of the Aconitum Kuznezoffi Reichenb. in intragastric course use. On the model of chemical pain stimulation in the peritoneum the phyto-drug showed analgesic activity comparable with the effect of indometacin. Conclusions. Aconite extract showed a mixed type of receptor response on the models with different profile of pain stimulation that allows to include it into a group of promising highly active analgesics with a complex mechanism of action.