STUDY OF PATHOGENIC MECHANISMS OF THE DEPRESSIVE DISORDERS
The purpose of this research was to study the peculiarities of psychopathological symptoms, humoral and cellular immune responses in patients with depressive disorders and neurotic psychotic levels. Simple, randomized comparative study in parallel groups involving 157 patients suffering from neurotic and reactive depression was carried out. The control group consisted of 50 healthy donors. Psychiatric symptoms were assessed by the modified cards Avrutskaya-Zaitsev and Hamilton scale. The study of cellular and humoral immune reactions was made by conventional methods. Patients with depressive disorders were observed with the criteria of the signs of depression HAM medium and high severity and unidirectional, but depending on the severity of the disease of varying severity changes in the immune system: inhibition of the oxygen - dependent systems neutrophils, hypo-immune globulinemia of G class, raising a total complement activity of serum, while with reactive depression immune disorders wore maladaptive nature, which manifested imbalance in systemic immunity - the load index and leuco - T -index. The study of the immune profile of patients showed that dysfunctional disorders of cellular and humoral immunity depends on the depth of psychopathological disorders. The role of the immune system in the pathogenic mechanisms of depressive disorders was shown. It is necessary in the scheme of the survey include the study of their immune status.