IMPACT ASSESSMENT OF CELL CARDIOMYOPLASTY BY MESENCHYMAL SREM CELLS (MSCS) ON INDICES OF CARDIOMYOCYTES METABOLIC ACTIVITY IN EXPERIMENTAL MYOCARDIAL INFARCTION
The article is devoted to the solving of an actual scientific problem which is the justification of the effectiveness of isogenic cell cardiomyoplasty in myocardial infarction during the experiment. Experimental research was carried out on animals of Wistar-Kayota inbred. The total study included 42 animals (14 rats each, respectively), which formed 3 equal in the number of animals groups. In our studies, we have demonstrated the basic pathophysiological mechanisms of myocardial infarction in rats, such changes as decreasing of lactate dehydrogenase, erythrocyte adenosine desaminase and Creatine kinase-MB after using of common MSC’s. The myocardial infarction was caused by coronary artery ligation with subsequent application of various kinds of cardiomyoplasty. Further on, according to biochemical research, we studied the dynamics of markers of myocardial damage, lactate metabolism, lipid peroxidation. The common MSC’s proved effective in our experiment. Our data are consistent with the world literature that can be recommended to refrain the use of this type of cellular cardiomyoplasty in the future clinic research.