Effect of extract of saw-wort ( <i>Seratulla coronate</i>) on the viability of white rats
The article presents the results of studies on the effect of alcoholic extract of saw-wort ( Seratulla coronata ) on the viability and survival of white rats after injection of maximal doses of preparation. The experiment was made under laboratory conditions; animals are selected on the basis of analogs principle with 5 months age and weight of 150 ± 3 grams, clinically healthy. Five groups with 6 animals in each were formed. Dried alcoholic extract of S. coronata after dissolving in distilled water was injected intraperitoneally. At the end of the experiment body weight of rats increased by 13 ± 3 g; studied blood parameters in the experimental and control groups were roughly in the same boundaries that do not go beyond the norm; internal organs had no any pathological changes. Indicators of mass coefficients of internal organs of experimental and control animals did not differ significantly with each other (P<0.05). Rats of experimental group had: heart weight 0.32 ± 0.01; lung 0.75 ± 0.00; liver 3.19 ± 0.12; kidney 0.37 ± 0.02. Rats in the control group had: heart weight 0.30 ± 0.07; lungs 0.73 ± 0.00; liver 3.06 ± 0,01; kidney 0.36 ± 0.01. Histological examinations of the internal organs are not found significant changes in their structure. As the result it was found that intraperitoneal injection of S. coronata extract to rats at doses of 400, 600, 800, and 1000 mg/kg did not cause adverse effects. Complex of obtained data allows to conclude that extract of S. coronata at parenteral administration even in high concentrations has no negative effect on the body of experimental animals.