Antibodies to purine metabolizm enzymes as factor of enzymatic activity regulation in systemic sclerosis
Antibodies to Adenosine Deaminase (AD) and Guanin Deaminase (GDA) were founded in sera of systemic sclerosis (SS) patients, their concentration correlated with the activity of the disease. It is shown that AD enzymatic activity decreased while activity of GDA increased. Th e data we obtained demonstrate that antibodies to AD and GDA invoke a change of enzymatic activity in vitro. Th e antibodies to enzymes may be one of the possible causes of change of enzymes activity in sera of SS patients. Th e method of immunoenzyme determination of antibodies level to AD, G on the basis of an immobilized form of magnet sorbent was developed for immune diagnostics of SS.