Genetic risk factors of venous thrombosis
Objectives. To determine the distribution of prothrombotic polymorphisms in patients with venous thrombosis in comparison with the control group and in different groups of patients with thromboses of inferior vena cava. Methods. 43 patients without venous thrombosis in the anamnesis were investigated as well as 169 patients with phlebothrombosis of the lower limbs, divided into groups according to the age and the cause of the disease. The genes of plasma, platelet hemostasis factors, folate cycle enzymes were studied. Results. The effects of polymorphism genes V factor of coagulation, methylenetetrahydrofolate reductase, tissue plasminogen activator, VII coagulation factor and fibrinogen on the development of thrombosis, particularly early and idiopathic were reliably revealed. Conclusion. The risk of venous thrombosis development is increased not so much by general number of involved genes, but by single polymorphisms having reliable influence on the development of the given disease. Correction of the conservative therapy in patients with the developed phlebothrombosis is possible on the ground of gene-typing as well as preventive methods in the patients of risk group.