ROLE OF PROINFLAMMATORY CYTOKINES IN PATHOGENESIS OF PURULENT INFLAMMATORY DISEASES OF UTERUS APPENDAGES
The content proinflammatory cytokines in blood plasma (IL-1β, IL-6, TNF-α) at 37 women with various forms of a purulent inflammation of appendages in dynamics of disease has been studied. There was a control group out of 23 healthy women. The detection of the level of interleukins in blood serum carried out with the help of an enzyme-multiplied immunoassay (EMI) method. It was revealed that when there were purulent inflammatory diseases of appendages of the uterus then the significant increase in all proinflammatory cytokines especially expressed for IL-6 was observed. The highest levels of studied cytokines were among patients with heavy destructive processes in the area of appendages of the uterus and at development pelviperitonitis. By the time of the termination of the treatment the content proinflammatory cytokines in peripheral blood at all group of sick women had decreased to standard values, except for IL-1β. However, patients with the complicated forms of a purulent inflammation of appendages of the uterus had IL-1β, IL-6, TNF-α factors. These factors remained authentically higher, than the factors of healthy patients, even by the time of the basic treatment termination. Thus, IL-1β, IL-6, TNF-α content in blood plasma can be considered as markers of intensity of inflammatory process in the uterus appendages. It can be used to predict a flow of disease and choose medical tactics.