THE PATHOPHYSIOLOGICAL ASPECTS OF INFLUENCE WITH CHRONIC TOBACCO SMOKING ON MICROCIRCULATION SYSTEM
The aim of this study was investigate pathophysiological aspects of damages in microcirculation and endothelium-dependent vascular reactivity in patient with tobacco smoking. In this study take part 68 patients. The microcirculation was examined with method laser-Doppler flowmetry. We studied the amplitude-frequency characteristics, as well as conducted tests with vasoactive agents. Revealed that using of tobacco reduce the level of myogenic activity resistive precapillary microvessels and sphincters on 2,1 % (<i>p</i> < 0,05) and increase venous flow, synchronized with the respiratory rhythm on 11,3 % (<i>p</i> < 0,05) as well as the index of vascular resistance at 11,5 % (<i>p</i> < 0,05). In addition, using of tobacco reduce microcirculatory endothelium-dependent vascular reactivity to histamine and acetylcholine (<i>p</i> < 0,05).