Nanovesicular therapy. Evolution of the conception, the current state and prospectives. Communication 1. Nanovesicular therapy of acute kidney injury
This article is dedicated to evolution of the concept of nanovesicular therapy, the current state of the method, and its prospectives. The publication is conceived as the first of the series concretizing the method by the example of acute kidney injury treatment. The background of the topic, bibliometrics, terminology, classification, extracellular vesicles structure, methods of vesicles detection, study, production and standardization are considered. The preclinical studies and the only so far clinical trial are analyzed in detail. The conclusion that nanovesicular therapy possesses the obvious translational capacity in the treatment of acute kidney injury is made.