THE ENZYMES OF BLOOD PLASMA AND HEPATIC TISSUE IN CHILDREN DEPENDING OF STAGE OF TRANSITION TO CHRONIC STATE OF VIRAL HEPATITIS
The detection of activity of enzymes in hepatic tissue and whole blood in children aged 12-16 years with chronic viral hepatitis was carried out. The results of study demonstrated that the level of metabolic parameters during the third stage of transition of disease to the chronic state as compared with the second stage testifies the presence of deeper functional affection of hepatic cells and more expressed metabolism disorders. The character of ratio of levels of activity of enzymes in liver and blood of children under the second and third stages of transition of disease to chronic state was analyzed. It is affirmed that the blood enzymatic indicators reflect specificity and direction of alterations of metabolic processes in hepatic cells under chronic hepatitis C. This process can be used as a basis for development of new diagnostic approaches to this form of pathology.