A comparative study of morphological changes occurring in experimental staphylococcus endophthalmitis using antimicrobial photodynamic therapy with methylene blue and intravitreal vancomycin injections
180 eyes of 90 chinchilla rabbits were used to produce experimental staphylococcus endophthalmitis by introducing intravitreally 0.1 ml (150000 staphylococcus aureus microbial bodies, АТСС 25923F-49). The experimental study involved three groups of 30 rabbits each: the control group 1 who received no treatment, the experimental group 2 which received antibacterial photodynamic therapy (APDT) with 3-minute diode laser radiation (wavelength 630-670 nm) with 0.1% methylene blue (MB) from the second day of infection, and the experimental group 3 that received intravitreal injections of 1.0 mg Vancomycin on days 2 and 5. The results of histomorphological studies showed that the use of APDT with 0.1% MB brings about a rapid repair of structures of the anterior and the middle parts of the eye, while the use of Vancomycin enables the restructuring of the posterior parts of the eye and retrobulbar tissues. // Russian Ophthalmological Journal, 2014; 1:62-67.