DEVELOPMENT OF NON-INJECTABLE MEDICINAL DRUGS ACTING ON CNS FOR EMERGENCY THERAPY
Algorithm of selection of compounds and formulations for development of multi-purpose CNS targeted medicinal products for emergency field and civil therapy is justified on the example of potent analgesics. Key criteria and quantitative parameters for selection of substances and dosage forms are singled out. The advantages of strong synthetic opioids vs traditionally used morphine, its derivatives and analogues are demonstrated. Advantages of multi-target formulations are shown. Choice of transmucosal dosage forms of analgesics, antiemetics and antidotes for urgent therapy is substantiated. Approaches to development of universal pharmacological platform for creating drugs acting on CNS are proposed. The current situation in the field of potent analgesics and other limited use medicines in the Russian Federation is described, problems are noted and possible solutions are suggested.