CARDIOTOXIC EFFECT OF IZONIAZID
Izoniazid being the basic medicine in any treatment for patients with tuberculosis apart from the toxic damage of the liver, central and peripheral nervous system has an insufficiently studied cardiotropic effect. Izoniazid effect on the myocardium contractile function was studied in the experiments on 40 white male rats by using different izoniazid doses (15, 30, 75, mg/kg). It has been established that enteral administration of the substance for two months contributes to reducing the strength and velocity rate, myocardium diastolic dysfunction in the isolated izovolumically contracting heart. It has been shown that cardiomyocyte membranes are damaged under the influence of izoniazid that is accompanied by the increased aspartataminotransferasa leakage into the coronary duct. The myocardial bioenergetics disorder associated with greater glucose consumption per the implementing functional unit occurs.