Changes in Metabolic Processes Depending on the Degree of Dysplastic Scoliosis in Children
In 45 children aged 7-15 years with dysplastic scoliosis of I-III degree before conservative treatment we studied indicators of electrolytes, proteins, lipids and enzyme activity in blood serum. It is found that in children with dysplastic scoliosis, regardless of disease degree, there is a reduced activity of ALT, LDH and alkaline phosphatase, which indicates the deficiency of energy metabolites and reduced osteoblastic processes. The changes in metabolism depending on the degree of dysplastic scoliosis were noted. It is shown that the initial manifestations of spinal deformity occur against deficiency of energy metabolites. Progression of the disease (II-III degree) is combined with reduction of final products of proteins degradation and nucleoproteins in blood serum, decreased activity of amino acids transamination and transport of them into cells, as well as calcium and magnesium deficiency.