The usage of standard immunoglobulin intravenous administration for treatment of severe forms of flu
In the article the characteristics of existing immunoglobulin classes and their effect on the immune system and the course of some infectious diseases are presented. It is emphasized that the main indications for their use is substitution therapy in patients with primary and secondary (HIV) immunodeficiency conditions, as well as in patients with some autoimmune diseases.In spite of the fact that the experience in usage of the immunoglobulin for intravenous administration for the treatment of infectious diseases is limited, some publications of recent years emphasize itseffectiveness for the treatment of sepsis, community-acquired pneumonia, including cases caused by pandemic strains of influenza virus, as well as highly pathogenic bird flu.Also in the article a general characteristic of the course of flu during 2015-2016 seasons, in which H1N1 pdm09 flu dominated, is provided. The main complication of influenza was the development of acute respiratory distress syndrome in adults, which was the main cause of death of patients. Many patients had lymphopenia, low levels of IgG and IgM. These changes correlated with the severity of the disease. According to the author, these facts suggest that the influenza virus A/ California/7/2009 (H1N1) pdm09 is able to cause immunosuppressive condition which induces ineffectiveness of standard therapy. Also, article focuses on the possibility of severe complications of the central nervous system caused by flu.Own clinical observations and experience of the successful use of intravenous immunoglobulin administration in patients with severe forms of influenza are presented.