ROLE OF COL1A1 GENE -1997 C>A POLYMORPHISM IN OSTEOPOROSIS DEVELOPMENT IN SKELETON VARIOUS SITES IN POSTMENOPAUSAL WOMEN
The aim of the study was to assess the role of COL1A1 gene -1997 C>A polymorphism in osteoporosis development in skeleton various sites in postmenopausal women. Examination of 483 postmenopausal women included densitometry by dual-energy X-ray absorptiometry method and COL1A1 gene -1997 C>A polymorphism detection by PCR method. It was established that A allele was a predictor of postmenopausal osteoporosis in the zone of both femoral proximal departments and also both femoral necks (p<0.05), but C allele and CC genotype had a protective effect (p<0.05). The role of -1997 C>A polymorphism of COL1A1 gene in the development of osteoporosis in L1-L4 lumbar vertebrae and forearm distal department was not established (p>0.05). The obtained data can be useful for the detection of predisposition to osteoporosis and treatment-and-prophylactic activities individualization.