REDUCED EXPRESSION OF DOPAMINE D2-RECEPTORS BY PERIPHERAL BLOOD LYMPHOCYTES AS A MARKER FOR PROGRESSION OF SUBCORTICAL VASCULAR COGNITIVE IMPAIRMENTS
We studied the expression of dopamine D-2 receptors on peripheral blood lymphocytes (indirect immunoperoxidase method by the number of D-2 positive cells per 100 lymphocytes) in 18 patients with subcortical vascular mild cognitive impairment (SSLKP) and 10 patients with initial stages of subcortical vascular dementia (WDS). It is shown that the expression of dopamine D-2 receptors on lymphocytes decreased in severity as the growth of subcortical cognitive deficits, making the group SSLKP 19.5 (19–20) and in SSc group – 18.5 (18–19) (P = 0.016 ). It is concluded that downregulation of dopamine D-2 receptors of lymphocytes may be a marker of the transition SSLKP in SSc and display downregulation of postsynaptic D-2 dopamine D-2 receptors in the frontal-subcortical regions of the brain.