Genetic risk factors for preeclampsia in primipara women
In 109 primipara women (48 pregnant women with varying degrees of severity of preeclampsia, 41 of high-risk group, 20 - healthy nulliparous women) were studied hemostasis state, gene polymorphism AGT-M235T, ACE I / D, MTHFR-C677T, 4a/4b gene NOS3 and E298D, the level of folic acid (FA), angiotensin-converting enzyme (ACE) and renin - angiotensin (RA). It was established that the expression of mutant genes with decreased FA and increased RA is always accompanied by hemostatic disorders and hypertensive syndrome of varying severity. Concluded that the development of preeclampsia in primipara women is genetically determined; folatdeficiency status are additional, potentiating pathology factors.