INVESTIGATION OF ANGIOGENESIS FACTORS IN CEREBRAL ARTERIOVENOUS MALFORMATIONS WITH DIFFERENT CLINICAL PATTERN
BACKGROUND AND AIMS: There are genetically predisposed mechanisms of growth of cerebral arteriovenous malformation (AVM), which are caused by increase of factors of angiogenesis. The aim of the study was to evaluate the level of these factors in patients with cerebral AVM before and after endovascular treatment. METHODS: we have determined the level of serum concentration of three main factors: vascular endothelial growth factor (VEGF), angiopoetin-2 (ANG-2) and matrix metalloproteinases-9 (MMP-9) in 145 patients with cerebral AVM before and 24 hours after endovascular intervention with use of chemoluminescent immunoassay (IMMULITE 1000, Personal Lab, “Adaltis”, Italy). Control group of 10 healthy volunteers was used for comparison. RESULTS: Average VEGF level in blood serum of the patients with cerebral AVM was 26 (17,9%), MMP-9 - 27 (18,6%), and ANG-2 - 11 (7,6%). In 24 hours after partial embolization, we have noticed significant decrease in VEGF MMP-9, and nonsignificant increase of ANG-2. The total embolization of AVM led to decrease of all angiogenic factors postoperatively. CONCLUSIONS. Thus, partial embolization leads to an increase of angiogenic factors that could induce further growth of pathologic vessels of AVM. This should be taken into account for adequate planning of surgical treatment in patients with AVM.