Morpho-microcirculation profile of gastroduodenal mucosa in different phases of peptic ulcer and in depending on motor activity in peptic ulcer patients
To investigate gastric and duodenal mucosal blood flow (MBF) in different phases of gastric (GU) and duodenal ulcer (DU) and its relation both to Нelicobacter pylori (HP) infection and gastric and duodenal motility. Upper endoscopy and histological examinations were performed in 5107 patients with peptic ulcer. Gastric and duodenal МBF were assessed by the hydrogen gas clearance technique. HP was determined by histology. Lowering of MBF in gastric antrum and duodenum were observed in DU and GU patients only with 3 score of HP infection. DU healing is accompanied by a significant increase MBF: in duodenum in stage of white scar; in gastric antrum and body - in healing stage, but a decrease in white scar. During healing of GU gastric MBF exhibited maximum in active ulcer, but in white scar MBF was significantly lower. In all patients during the motor activity versus its absence MBF showed an increase on average in 1,6 times in all parts of gastroduodenal mucosa. The changes of MBF in different phases of ulcer is, in part, determined both by HP and by mucosal morphological disorders. Gastroduodenal blood flow depending on motor activity in peptic ulcer patients.