ЭПИЛЕПСИЯ ЖӘНЕ ЖҮКТІЛІК: ЭПИЛЕПСИЯҒА ҚАРСЫ ПРЕПАРАТТАРДЫҢ ТИІМДІЛІГІ ЖӘНЕ ТЕРАТОГЕНДІГІНІҢ ТАЛДАУЫ
Review of the literature devoted to contemporary issues of antiepileptic therapy pregnant various drugs, identifying the most effective of them according to scientific publications from 2006 to 2016. (PUBMED, MEDline, The Cochrane Lb.) It is presents the current literature data on the frequency of occurrence of seizures in pregnant women, on the specifics of therapy with antiepileptic drugs (AEDs), the frequency of fetal malformations in pregnant women, taking AEDs regularly, and their dependence on the frequency, dosage and the nature of the therapy. Were studied according to the literature such AEDs as lamotrigine, phenytoin, carbamazepine, valproic acid, phenobarbital, as well as new drugs (vigabatrin, gabapentin, topiramate, tiagabine, oxcarbazepine, levetiracetam, pregabalin). It was found that the risk of birth defects in children observed in the application of high doses of drugs in polytherapy than with monotherapy. The studies revealed new data on the effect of psychotropic drugs on the fetus, allowing them to assess the ratio of "risk / benefit" and to develop recommendations on rational pharmacotherapy in pregnancy in recent years.