EFFICIENCY OF POTASSIUM HUMATE MEDICATION OF LACTATING COW HEPATOSIS
The authors present the results of studies on the evaluation of therapeutic efficiency of potassium humate medication of lactating cow hepatosis. Experiments were conducted on 25 animals of Simmental breed, divided into 5 groups (2 control and 3 experimental). All experimental animals were kept under the same conditions and on the general diet. Cows of the 1<sup>st</sup>, 2<sup>nd</sup> and 3<sup>rd</sup> experimental groups in the next 30 days in addition to fodder received potassium humate at a dose of 10, 20 and 30 mg/kg bwt, respectively, and positive control group cows - sodium humate at a dose of 20 mg/kg bwt. The most significant changes in hematological status were observed in cows of the 1<sup>st</sup> experimental group. In the blood of animals of this group the authors registered an increased level of leukocytes (by 5.4%), erythrocytes (by 3.9%), thrombocytes (4.7%), hemoglobin (9.5%), total protein (6.6%), glucose (9.0%, p < 0.05), total lipids (6.1%), cholesterol (21.3%, p < 0.01), total calcium (7.4%), iron (14.7%, p < 0.01), manganese (13.8%, p < 0.05), zinc (9.4%, p < 0.01), carotene (7.7%), retinol (14.1%), tocopherol (11.9%), and a decreased level of copper (18.7%), total bilirubin (20.4%, p < 0.01), urea (9.7%, p < 0.05), creatinine (12.3%), ASAT activity (9.7%, p < 0.05), ALAT (21.0%) and ALP (17.6%). Feeding of potassium humate to cows contributed to a better motor function of the rumen, reduced stiffness in extremities and liver algesthesia when percussing; stimulated appetite and increased milk producing ability by 2.8-5.1%; reduced the severity of syndrome of liver cell failure, as well as cytolytic and cholestatic syndromes; normalized protein, carbohydrate, lipid, vitamin and mineral metabolism, functional status of the liver and kidneys; increased alkaline reserve; positively influenced leuko-, erythro-, hemo- and thrombopoietin function of bone marrow. It is shown that hepatosis in lactating cows occurs in combination with ketosis, osteodystrophy, hypovitaminosis, microelementosis, forestomach dystonia and reproductive function disorder.