STUDYING OF INFLUENCE OF THE PREPARATION "EDICIN" ON INDICATORS OF PERIPHERAL BLOOD
Fourteen-day application of the preparation «Editsin» in doses of 172 and 860 mg/kg testified to development of considerable shifts in qualitative and quantitative structures of uniform elements of blood. These changes were characteristic for developing against intoxication an antibiotic of defeats, first of all renalny and gepatobiliarny systems, and also could be realized during direct influence of an antibiotic on stages hemopoiesiseritrotsitarny, leykotsitarny and trombotsitarny sprouts. Introduction edithin was accompanied by development of moderate anemia with characteristic quantitative and morphological changes of erythrocytes, activation thrombocytopoiesis and considerable change of leykotsitarny composition of blood. After preparation cancellation within 14 days there is no complete recovery of hematologic indicators, and opposite to change get a new form about preservation of shifts practically on all indicators (a leykopeniye, monocytosinging, decrease in a share of young neutrophils). The listed changes of a picture of a peripheral picture of blood are more expressed when using antibiotic in a toxic dose of 860 mg/kg.