EFFECT OF IMPLANTATION OF HYDROXYLAPATITE INTO THE TIBIA AND ORAL ADMINISTRATION OF CALCIUM DRUGS ON THE STRUCTURAL STATE OF THE PROXIMAL EPIPHYSEAL CARTILAGE OF THE HUMERUS
The research purpose was to investigate the structure of the proximal epiphyseal cartilage of the humeral bone of white rats after implantation of the OK - 015 material into the tibia and to consider correction of alterations with the dietary supplement “Biomin MK”. Materials and methods. The study involved 168 white male rats weighing 135 - 145 g: group A - control, group Б - animals with fracture modeled perforation; group В - OK - 015 material was implanted into the perforation in tibia of animals, group Г - animals received dietary supplement "Biomin MK" intragastrically at a dose of 90 mg/kg/day after application of perforation. Results and discussion. The application of a perforation in the tibia was accompanied by a narrowing of the osteogenic zone, as well as primary spongiosa and the osteoblasts amounts in it with maximum alterations by the 30th days of experiment. The implantation of the OK - 015 material was accompanied by the aggravation of the alterations up to 30th days, but the restoration of the structure of the epiphyseal cartilage was faster after 30 days. The width of the osteogenic zone was greater than the values of the group В from 15th to 60th days by 6.08%, 9.24% and 4.57%, the primary spongiosa amount by 15th and 30th days - by 4.83% and 6,49%, and the osteoblasts amount by 30th day - by 5.50% in group with intragastric administration of "Biomin MK". Conclusion. The administration of "Biomin MK" after implantation of the OK - 015 material into the tibia is accompanied by the restoration of the bone formation activity of the proximal epiphyseal cartilage of the humerar bone mainly from 15th to 30th days after the fracture development.