CARDIOVASCULAR RISK ANALYSIS AMONG OSTEOARTHRITIS PATIENTS
In the article the occurrence of the influence of metabolic disorders on the progression of atherosclerosis and the increase of cardiovascular accidents risks among osteoarthritis patients were studied. With this aim 83 patients with a positive osteoarthritis diagnosis (American College of Rheumatology criteria) with the 2-3 X-ray phase of the disease according to Kellgren-Lawrence were examined. The obesity was diagnosed at 51 patients with osteoarthritis (67, 64%). Among these patients, compared with the results of the survey among women with the body mass index less than 30 kg/m<sup>2</sup>, the synovitis became apparent more, there were registered higher algo-functional index value, reliable increase of the C-reactive protein and interleukin-6 content. In the group of osteoarthritis patients with obesity cardiovascular diseases and cardiovascular accidents occurred more often than among the patients whose body mass index was less than 30 kg/m<sup>2</sup>. Among the osteoarthritis patients there were more women with obesity than women with the body mass index less than 30 kg/m<sup>2</sup>, that coincides with the literature data about the influence of weight on the development of the degenerative joint disease. Besides, among the women with osteoarthritis and obesity, comparing to the survey results of patients with the body mass index less than 30 kg/m<sup>2</sup>, there were registered higher concentration of the thyroid-stimulating hormone, low level of the lipoprotein cholesterol of high density, level up of one of the inflammation markers - C-reactive protein and the Caro index value less than 0,33 that is one of the insulin resistance diagnostic features. The gained data allow us to talk about the formation among women with osteoarthritis and cluster obesity the factors, that point to a high risk of cardiovascular pathology development.