THE LEVEL OF MATRIX METALLOPROTEINASE-8 IN NEWBORNS WITH RESPIRATORY DISODERS
Recently the work of many clinicians has focused at solving problems associated with the birth of premature babies and children whose mothers had a complicated obstetric and gynecological history of inflectional diseases. The study included 40 newborns with signs of respiratory disorders from birth (25 newborns with congenital pneumonia, 15 patients with RDS type 1), the comparison group included 20 children without pathology of the tracheobronchial tree. Children of the research group were born at 34 - 37 weeks of gestation, body weight was 1 750 -2 940 g, length 40 -45 cm. The level of MMP-8 in children with respiratory disorders was higher in comparison with children from the control group. The blood concentration of MMP-8 at the first day of life: in children with congenital pneumonia 7,0269 ng/ ml [25 -75 IQR 6,841 - 9,326 ng/ml], in children with RDS 4,507 ng/ml [25 -75 IQR 3,124 - 5,542 ng/ ml]. When we studied the level of MMP-8 on days 10 -14 of life in children with congenital pneumonia - 11,334 ng/ml [25 -75 IQR 10,952 -12,36 ng/ml], in children with RDS-8,0379 ng/ml [25 -75 IQR 6,574 - 9,253 ng/ml]. We make a conclusion that the desired marker can be used as an indicator of the inflammatory process of the respiratory tract.