Herpesvirus infections and the problems of infectious safety of haemotransfusions in immunosuppressed patients (review)
Review literary and authors data. Herpesviruses and especially Cytomegalovirus (CMV) are the important infectious pathogens in transplant recipients, including those receiving bone marrow or stem grafts as well as in other immunosuppressed patients. In the review the properties of herpesviruses (Herpes simplex viruses 1 and 2, Varicella-zoster virus, Cytomegalovirus, Epstein-Barr virus, Human herpesvirus type 6, 7 and 8 and their role in the safety of haemotransfusions are analysed. The newly identified viruses: herpesvirus type 6, 7 are not so pathogenic as CMV but herpesvirus type 6 at least can cause infectious complications and bone marrow suppression. The methods of prevention of herpesvirus haemotransfused infections (screening, leukofiltration and other) are discussed.