The relations of Staphylococcus aureus with clinical and laboratory parameters in children with atopic dermatitis
The study involved 90 children with atopic dermatitis at the age of 4.0 (1.0-10.0) years. There was done microbiological testing of mucus of tonsils, urine, normal and abnormal skin. The diseaseseverity was assessed with the help of the SCORAD. S. aureus was obtained in 75.5% (95% CI 66.7- 84.3) of children; 48.1% (95% CI 36.8-58.4) of children have methicillin-resistant S. aureus strains. Among patients with Staphylococcus aureus, mild dermatitis after treatment was diagnosed in 66.1% (95% CI 54.9-77.3). In the absence of S. aureus mild dermatitis is diagnosed in 95.4% (95% CI 86,7-100,0) (p=0.008) of patients. Patients with eczema have more biotopes that contain S. aureus (2.0 (1.0-2.0)), if compared to other forms (1.0 (0.0-2.0), p = 0.03). SCORAD value at the time of the initial examination is significantly higher in children with the growth of S. aureus in 2 biotopes (51.0 (32.0-72.0) points), than in the absence of its growth (26.0 (16.0-39.0)) points, p=0.008). Block points А, В and С are also higher in children with S. aureus in 2 biotopes, than without it (p<0.05 in all cases). Mild dermatitis was identified in 95.4% (95% CI 86,7-100,0) of children with absence of S. aureus at the time of final examination, but it present in 2 biotopes - 59.2% (95% CI 40,7-77.7) (p = 0.04). The number of biotopes with S. aureus was significantly higher (2.0 (2.0-2.0)) in children with CD4 + cells infiltrate in the dermis, than at the absence of it (1.0 (1.0-1.0), p=0.02). On the contrary, the number of biotopes with S. aureus was significantly lower (1.0 (1.0-1.0)) in the presence of CD4 + cells in the epidermis, than in the absence of it (2.0 (1.5-2.0), p = 0.01). In the presence of hyperkeratosisaureus was identified in 1.5 (1.0-2.0) biotopes, which was significantly higher than in its absence (1.0 (0.0-1.0), p=0.009).