DETERMINATION OF BIOLOGICAL ACTIVITY OF DERIVATIVES N7-ARYL/BENZYL-3-(8-OXO-7,8-DIHYDRO[1,2,4]TRIAZOLO[4,3-a]-PYRAZIN-3-YL)CARBOXYLIC ACIDS
With the help of the PASS program computer prediction of biological activity of the virtual library prepared on the ground of the basic structure of [1,2,4]triazolo[4,3-a]pyra-zine was carried out. According to the results libraries of N7-aryl/benzyl-3-(8-oxo-7,8-dihydro[1,2,4]triazolo[4,3-a]pyrazine-3yl)carboxylic acids and their amides were generated, and by previously developed techniques the synthesis of a number of substances was conducted to assess their impact on lipid metabolism.