The effectiveness of the use of fumaric and succinic acids salts in combined lesions of rabbits
Introduction . The article presents the results of studies of succinic and fumaric acids salts in combined lesions with ionizing radiation and toxic elements. Materials and methods . Six experimental groups of rabbits (males) of the Chinchilla breed with a live weight of 2.7-3 kg were formed, 3 heads each. Observation of animals and administration of drugs was carried out for 30 days. The first group served as biological control. Experimental groups of animals were exposed to ionizing gamma radiation at a stationary gamma installation “Pumaˮ at a dose of 5 Gy and priming with heavy metals (cadmium chloride and lead acetate at a dose of 5 MPC), and simultaneously received the studied preparations together with shungite (1 % of dry matter) and zeolite (1 % of dry matter). The third group received calcium succinate at a dose of 25 mg/kg, the fourth - ammonium fumarate at a dose of 25 mg/kg, the fifth - succinic acid at a dose of 25 mg/kg, the sixth - succinic acid and calcium succinate at 25 mg/kg. Research results. There were no deaths in all experimental groups. In animals of the second group, there was a decrease in body weight (by 15 %), the number of leukocytes by 25 %, monocytes by 20 %, granulocytes by 32 %, and the content of erythrocytes by 21.5 %. In the groups receiving the drugs, leukocytes decreased by an average of 12 %, granulocytes - from 12 % to 15 %. Conclusion . According to electron microscopic studies, it was revealed that in the liver of rabbits, the simultaneous intake of succinic acid and calcium succinate together with sorbents provides cells with a protective effect compared to the action of these drugs separately.