ROLE OF INTRARENAL MONONUCLEAR CELLS APOPTOSIS IN THE MECHANISMS OF PATHOGENESIS <i>IGA</i>-NEPHROPATHY IN PATIENTS WITH DIFFERENT AGE GROUPS
Apoptosis plays an important role in the mechanism of regulation of the development of glomerulonephritis. We explored the role of apoptosis of mononuclear cells in patients with intrarenal <i>IgA</i>-nephropathy in different age groups and its relation to clinical laboratory, the morphological pattern of the disease. The position of the acceleration of the process of apoptosis intrarenal mononuclear cells in the elderly was conﬁrmed. The effect of <i>Fas</i> antigen by intraglomerular mononuclear cells on systolic and diastolic blood pressure, regardless of the patient's age and its importance in the development of hypertrophy of arteries and arterioles of glomerulus and formation fuksinophilea deposits in the glomerulus were found. It is also shown that the infectious antigen (<i>cytomegalovirus</i> and <i>Chlamydia trachomatis</i>) differently affects the process of apoptosis of mononuclear cells.