Rational combination of medications for the treatment of vascular pathology in geriatrics
We undertook retrospective analysis of combination of medications recommended for the long-term treatment of co-morbid vascular pathology (arterial hypertension + coronary heart disease+ vascular atherosclerosis) in elderly patients (women, mean age 73±4 yr) hospitalized in a multidisciplinary clinic of the Perm krai from January 2010 to December 2014. Data on the interaction (type A reactions) of concurrently prescribed drugs were compared with those of the National Register of Medicinal Remedies and WHO Classification of Adverse Drug Reactions. Polypragmasia was found to be a characteristic feature of all recommended combinations (4-5 medications were simultaneously prescribed to 56.7% of the patients and 6 or more drugs to 43.3% of them). Nine combinations of drugs were distinguished among those prescribed to elderly patients with vascular co-morbidity. Probability and peculiarities of their interaction (type A reactions) were analyzed and optimal combinations in terms of safety for the treatment of vascular co-morbidity identified.