METHODOLOGY AND METHOD OF EVALUATION OF OXIDATIVE MODIFICATION OF PROTEINS IN COMPLEX WITH AVERAGE WEIGHT MOLECULES, PROSPECTS FOR THEIR USE
Study of oxidative modification of proteins (OMP) and the average mass molecules (MSM) as markers of the se- verity of endotoxemia, sensitive to changes in the degree of oxidative stress in the complex, one sample of the biologi- cal environment, methodologically justified, since it will increase the information content of each of these parameters and reduce the flow of material used, which is particularly important in clinical biochemistry. OMP evaluation method in combination with MSM implemented by us in accordance with the author’s method (patent for the invention of the Russian Federation no. 2012153044, priority of 12.07.2012, the decision to grant a patent on 14.04.2014, in collabora- tion) and tested on a model biological system conditions spontaneous and Fe2+-induced OMP.