The role of palmitic acid in implementation of apoptosis in cytomegalovirus infection in the gestation period
The gas chromatographic study of palmitic acid in the peripheral blood of pregnant women during III trimester, homogenates placentas of pregnant women has been conducted, as well as the study of placentas for the presence of nuclei syncytiotrophoblast villous apoptosis signs on the label ends of DNA fragments by ISEL-method (in situ end-labeling) for reactivation of chronic cytomegalovirus infection (titer of IgG antibodies to cytomegalovirus 1:1600) in the period of gestation. It was found that the reactivation of chronic cytomegalovirus infection during gestation increases the content of palmitic acid in pregnant women by 25% in the peripheral blood (p <0,001), in the homogenate placentas of women in childbirth by 15% (p <0,001), and helps to increase 2,9 times the number of cores of syncytiotrophoblast (p <0,001), which in turn can be a cause of complications during gestation period.