IMMUNOLOGIC CHANGES IN TRAUMATIC BRAIN INJURY
Objective: The article is devoted to the defining of mechanisms of traumatic brain disease development, as well as the diagnostics and examination of the closed head - brain injury based on the detection of autoimmune antibodies, antibrain autoantigens, changes of immunoregulatory cells ratio. Results: The studies were conducted on the basis of contemporary literature data analysis and assess the possibility of using materials obtained in clinical practice. The authors carried out the work on the determination of the auto-aggressive properties of antibrain antibodies in all periods of closed head - injury. This article notes the relationship between the severity of brain damage, the clinical course of the pathological process and the dynamics of immunological parameters. Conclusion: The relevance of this article is not in doubt, since the study of immune responses, the pathogenesis of their accounting, timely and competent correction allow at the present level to interpret the signs of traumatic brain disease, predict the occurrence of complications and consequences, and to treat them.