Urolitiasis: modern concepts of the possibility of using markers of damage to the renal parenchymal for the perfection of diagnostics and tactics of treatment
Currently, because of the introduction in practice new diagnostic clinical laboratory, biochemical, immunological and instrumental research methods, has significantly improved the quality of diagnosis of renal parenchyma damage in calculous pyelonephritis. One of the promising directions in the diagnosis of parenchymal damage of the kidneys is analysis of molecular markers. With special emphasis on the study of markers of cell damage, including the activity indicators of free radical oxidation and antioxidant system function. To detect the most prone of inflammatory complications of they are patients were offered use levels of proinflammatory cytokines analysis. It reviewed the results of studies evaluating the concentrations of interleukin 6, 8, tumor necrosis factor-а, in this case shows that cytokine levels can be used as markers of inflammation and potential infectious complications after ureteroscopy with unfavorable outcome, these indicators can to be more precise criteria than the data of urine crops. It concluded about the need for further research aimed at finding and introduction into clinical practice of diagnostic techniques objectification calculous pyelonephritis.