RELATION BETWEEN THE LEPTIN AND ADIPONECTIN AND BONE METABOLISM IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
The aim of this study is to evaluate associations between adipokines (leptin, adiponectin) and bone metabolism in the patients with severe and very severe stage of COPD. Material and methods: 63 patients with COPD and 55 healthy subjects were estimated. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry at the lumbar spine (LS) and left femur neck (FN). We estimated respiratory function testing serum levels of leptin, adiponectin, osteocalcine (OC), ßCrossLaps (ßCL). Results: We indentified decreased BMD characterized by T-score <-1,0 in 89% patients. Adiponectin, ßCL level was higher, but leptin level was low in COPD in comparison with the control. The level of OC was the same as in healthy people. There was a positive correlation between serum leptin and negative association between adiponectin, ßCL and BMD in FN and LS. Serum leptin positively correlated with the body mass index and total fat mass, serum adiponectin and ßCL had negative association with these parameters. There was a significant inverse relationship between leptin and adiponectin. Conclusion: these results show a potential role of adipokines in the increase of bone loss in COPD.