CYTOKINES SERUM LEVELS IN POSTMENOPAUSAL OSTEOPOROSIS
The recent osteoimmunology achievements demonstrate that the immune system is the key regulator for both osteoclasts and osteoblasts, and osteoporosis is a chronic immunomediated disease. The research objective is to study the serum levels of pro- and anti-inflammatory cytokines in post-menopausal osteoporosis. 180 postmenopausal women aged 60.0±0.77 have been examined. The bone tissue densitometry was carried out by dual-energy x-ray absorptiometry. IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α, INF-γ, IL-17A, OPG, RANKL levels in the samples of women’s blood serum were investigated by means of commercial enzyme-linked immunosorbent assay systems. It has been established that osteoporosis existence in postmenopausal women is combined with rising of IL-1-β, IL-6, IL-8, IL-17A, TNF-α, RANKL (P<0,05) levels and depression of IL-4 and IL-10 ones (P<0,05). Bone mineral density in all zones (L1-L4 lumbar vertebrae and left and right femural necks and proximal parts) or in certain sites of the women’s skeletons had negative correlations with serum IL-1-β, IL-6, IL-8, IL-17A, TNF-α, RANKL (P<0,05) and positive relations with IL-4, IL-10 and OPG/RANKL index. The majority of correlations are defined between proinflammatory cytokines (IL-1-β, IL-6, L-8, IL-17A, TNF-α, RANKL) levels. Besides, a direct link of blood serum OPG with IL-6, IL-8, IL-17A, TNF-α in the general group and also with IL-6, IL-17A, TNF-α and RANKL among the patients with osteoporosis has been found. The obtained data reflect pathogenetic mechanisms of postmenopausal osteoporosis and can be used to improve efficiency of treatment-and-prophylactic actions.