PHARMACOKINETICS OF 14C-BUTYRIC ACID IN WHITE MICE M.Ya.Golovenko, I.Yu.Borisyuk, O.B.Likhota The study of kinetics of the r^ocesses of absorption, transit and reabsorption of 14C-butyric acid, a representative of short-chain fatty acids, in the organism of experimental animals has been carried out. The results obtained show a high rate of absorption of the compound in blood plasma both with intravenous and oral administration. Pharmacokinetic parameters of absorption and elimination of 14C-bu-tyric acid from blood plasma have been calculated. When studying the correlation of areas under the "concentration - time" curves it was found that about 1OO% of the dose comes to the blood plasma. Absorption has been shown to occur with a sufficient speed in the lower gastrointestinal tract.4 The constants of absorption and elimination of 14C-butyric acid from all sections of the GIT have been calculated. It should be noted that the compound should be in undissociated form to affect the intestinal motility. After absorption butyric acid is quite easily distributed, so we calculated the constants of elimination rate from the relevant organs and tissues. In addition, the possibility of reabsorption (it has been clearly demonstrated by intravenous injection) and enterohepatic circulation (the presence of a radioactive material in the gallbladder) has been shown.
The study of kinetics of the r^ocesses of absorption, transit and reabsorption of 14C-butyric acid, a representative of short-chain fatty acids, in the organism of experimental animals has been carried out. The results obtained show a high rate of absorption of the compound in blood plasma both with intravenous and oral administration. Pharmacokinetic parameters of absorption and elimination of 14C-bu-tyric acid from blood plasma have been calculated. When studying the correlation of areas under the “concentration - time” curves it was found that about 1OO% of the dose comes to the blood plasma. Absorption has been shown to occur with a sufficient speed in the lower gastrointestinal tract.4 The constants of absorption and elimination of 14C-butyric acid from all sections of the GIT have been calculated. It should be noted that the compound should be in undissociated form to affect the intestinal motility. After absorption butyric acid is quite easily distributed, so we calculated the constants of elimination rate from the relevant organs and tissues. In addition, the possibility of reabsorption (it has been clearly demonstrated by intravenous injection) and enterohepatic circulation (the presence of a radioactive material in the gallbladder) has been shown.