THE SIGNIFICANCE OF THE TYPE OF THE BCR/ABL1 FUSION TRANSCRIPT IN THE CLINICAL PRESENTATION AND STATE OF CHRONIC MYELOID LEUKEMIA IN CHILDREN
Chronic myeloid leukemia (CML) is characterized by a reciprocal translocation between chromosomes9 and 22, creating the different type of the fusion gene BCR/ABL1 (b2a2 or b3a2). With the aim to study the role of the molecular transcript type in clinical presentation, imatinib response we have done analysis in the group of patients 0-18 years with newly Ph-positive CML. This article presents results of correlation analysis between the transcript variant and clinical presentation of CML in children. During the study it’s determined the frequency of different BCR/ABL1 types in Belarusian children population with CML using molecular analysis of bone marrow and peripheral blood of 48 patients.In the result of this study optimal response was significance more frequency in patients with b3a2 transcript type.