STRUCTURAL AND FUNCTIONAL CHANGES IN THE LUNG OF RATS AFTER POISONING WITH TOXIC SUBSTANCES
At industrial facilities, accidents and man-made disasters are accompanied by the release of highly toxic pulmonotoxicants into the environment. At a high level of exposure, a toxic process is formed, damage to the respiratory system in the body. The article shows that when exposed to chlorine for 30 days, respiratory tract damage and structural and functional changes in the lung of rats are observed. The toxic effect of chlorine on the epithelial cells of the respiratory tract and the endothelium of the capillaries of the lungs of rats can be associated with the manifestation of its oxidizing properties. In addition, chlorine disrupts enzymatic reactions in tissues, inactivates oxidative defense enzymes, and changes the structure. Histological examination in the lungs of rats of the second group revealed venous stasis, alveolar edema, hemorrhages, and the use of a detoxifying product reduced the degree of pulmonary hydration and a decrease in the manifestation of pathological processes by increasing the antioxidant reserves of the lungs. In the course of the experiment, the efficacy and safety of a specialized detoxifying product combining bronchodilator, antispasmodic, immunomodulating and antioxidant properties for the prophylactic treatment of lesions of the respiratory system was revealed.