THE CONTENT OF SEX STEROIDS, GONADOTROPINS AND PROLACTIN IN THE BLOOD OF PATIENTS HAVING PROSTATE GLAND CANCER UNDER VARIOUS TREATMENT OPTIONS
The level of testosterone, estradiol, progesterone, and prolactin in the blood of patients having prostate gland cancer T3bN0M1b. has been studied. When the standard hormonal therapy was supplemented by docetaxel (6 courses of 75 mg/m2, every three weeks), the distinctive feature of patients was a sharp 8,5 times reduction of the level of estradiol and 3,3 times higher progesterone as compared to the parameters before treatment. Taking into account the possible influence of the therapy used on the links of hypothalamic-pituitary-testicle axis which correlates with the clinic effect, we believe such kind of therapy to be pathogenetically grounded for prostate gland cancer patients.