Influence of the Phlojodicarpus sibiricus extract on energetic status of rat brain cells after carotid artery occlusion
The paper deals with the influence of Phlojodicarpus sibiricus extract at the dose of 50 mg/kg body weight on ATP content, pyruvate kinase (PK) and Н+-АТPase activity in brain cells after ischemia-reperfusion. In total, 36 albino Wistar rats were taken into experiments. Bilateral occlusion of both common carotid arteries for 5 min. followed by reperfusion for 60 min. resulted in the disturbance of energetic processes in brain cells. It has been found that the extract in question increases the ATP concentration by 50 % and leads to a 1.5- and 1.7-fold induction of Н+-АТPase and pyruvate kinase activities respectively compared with the control animals.