Experimental substantiation for metabolic cytoprotection in dull cardiac trauma
On the model of isolated isovolumically contracting heart the direct assessment of myocardial contractility and its functional reserves in the early posttraumatic period on the background of introduction of trimetasidine injection has been conducted. There has been observed: increasing of pressure developed by the left ventricle 1,4 times both due to reduction of the diastolic pressure (1,3 times), and due to increasing of the systolic pressure (1,3 times) in the left ventricle cavity; increasing of peak contractility and relaxation myocardium rates (1,4 and 1,2 times, respectively); the best integrity of the membrane structures (lactate in the duct 1,3 times less, AsAT - 1,5-1,9 times less at the different stages of the hypoxic test); high myocardial contractility resistance to stress testing (high frequency rhythm test, hypoxic and hypercalcic tests).