Features spectrum digestive enzyme in laboratory animals and humans
One of the most common methods of administration of drugs in humans and animals is the enteral route (through the gastrointestinal tract). Available metabolic, physiological and biochemical differences in the gastrointestinal tract of humans and laboratory animals can cause significant changes in drug absorption. The composition of lipids, proteins and enzymes distribution along the gastrointestinal tract and may change the conveying speed of the binding drugs. The review discusses the features of the spectrum digestive enzyme used laboratory animals (rats, mice, rabbits, hamsters, mini pigs) and humans. Knowledge of the specific species differences in biochemistry allow the researcher to select the most suitable type of animals for preclinical testing of drugs, as well as provide optimal interpretation laboratory data. Influence of diet and nutrition to change the spectrum of gastrointestinal enzyme and study its effects on the human body the most appropriate animal species should be recognized a mini pig’s omnivore. The use of predators for this purpose is not recommended, because there is no distinct adaptive adjustment in the activity of digestive enzymes in response to a change in diet. Small animals (rats, mice, guinea pigs) are the most suitable animals for studying the mechanism of absorption and bioavailability of drugs in the form of powder or solution, larger animals (mini pigs, rabbits) are used to examine medicines without destroying the dosage form (enterosoluble tablets, capsules, etc.). Based on the study of literature can be recommended, for example, use of dwarf pigs for the study of drugs that are intended to be used in pediatric patients, as well as research related to dentistry. Influence of diet and nutrition to change the spectrum of gastrointestinal enzyme and study its effects on the human body should be evaluated on the dwarf pigs, because they, like people are omnivores.