The G308/308A polymorphisms in TNF-alpha gene and production levels of cytokine in norm and during the chronic inflammatory diseases of respiratory organs
The ratio of frequencies of G308/308A polymorphisms of TNF- α gene at inhabitants of the Adygheya Republic (0,844/0,156) is comparable with the European countries: France (0,888/0,112) and Spain (0,869/0,131) according to ALFRED (The ALlele FREquency Database). The 308A allele,which is less widespread in population (0,156), is increased in the general group of patients having bronchial asthma (0,290). Opposite effects are elicited of influence of G/A alleles, genotypes of 308 position of pro-motor area of TNF- α gene in the surveyed groups on FGA stimulated in vitro TNF- α production. Patients with bronchial asthma unlike donors have G308 allele and GG (normal homozygous) genotype which increase stimulated TNF- α production, and those with 308A allele, GA lower (heterozygotic) genotype decrease it.