Molecular markers and epigenetic risk factors of preeclampsia in the era of predictive medicine
The review presents data of modern medical literature about the possibility of using genetic polymorphisms and signalling molecules in personified prediction of preeclampsia - a complication of pregnancy associated with a high risk for maternal and perinatal morbidity, disablement and mortality. The identified molecular-genetic markers and epigenetic factors, an integral approach to understanding the pathogenesis of preeclampsia permit to form risk groups for development of preeclampsia and to carry out preventive and therapeutic measures aimed at minimising the impact of confounders of disease and preventing their outcomes for mother and child. The conclusion has been made that research in the field of genetics and epigenetics of preeclampsia offer a new tool for personified prediction of disease and enhance prognostic and prophylactic potential of modern medicine.