THE LEVEL OF THE B-HUMAN CHORIONIC GONADOTROPHIN IN BLOOD SERUM AND FOLLICULAR LIQUID AT WOMEN IN PROGRAMS OF EXTRACORPOREAL FERTILISATION
The serum beta-human chorionic gonadotrophin (sb-hCG) was evaluated by ELISA method in women with a tubal or tubal-peritoneal infertility (45 patients) before their entering in extracorporeal fertilization programs (ECF, study point 1), after hormonal induction of superovulation (study point 2), before embryo transfer (ET) (study point 3) and 3-4 weeks after ET (study point 4). B-HCG was investigated in follicular liquid (fB-hCG), taken at transvaginal punction of preovulator follicles (study point 2), too. Twenty eight healthy non-pregnant women and thirteen women with physiological pregnancy in terms of 3-4 weeks were observed as controls. Results have shown that the sB-hCG level raised in sp. 2 and reduced in sp. 3 in all observed women. At positive results of ECF the sB-hCG level has raised on 3-4 weeks of clinical pregnancy (sp. 4), and was higher than in women with negative results. However its concentration was smaller, than appropriate parameter at physiological pregnancy. B-HCG contained in smaller quantity in follicular liquid than in blood serum. The correlation analysis of the obtained data has allowed to make a conclusion, that the formation of pregnancy, as well as development of multifetal gestations, in ECF programs, is connected with the high initial B-hCG concentration in serum blood (sp. 1) and, on the contrary, its low level in follicular liquid.