IMPACT OF UNFAVORABLE HOUSING CONDITIONS OF ANIMALS TO FORMATION OF ANTI-RABIES IMMUNITY
It was studying the influence of adverse animal welfare on formation of rabies immunity in guinea pigs. After rabies vaccination different groups of animals were subjected to high and low temperatures and nutritional stress. Before vaccination in the term of 7, 14, 21, 27, 41 days all the animals were taken samples of blood, serum and established antibody titers to rabies virus by the method TF-IFA. The research has established that the highest influence of adverse animal welfare on formation of rabies immunity was in the group of guinea pigs which were subjected to nutritional stress. Its influence due to rabies immunization of animals revealed low formation of specific antibodies which title was below the minimum protective level while the rabies titles of control group of animal were at this level (>0,5 MO/сm <sup>3</sup>). In keeping animals in low and high temperatures was observed the formation of rabies antibodies which level on the 41st day was lower compared with the blood serum of animals of the control group 73 and 43 % appropriately. However, the results confirm the effectiveness of vaccination at the end of the experiment, because rabies antibody titers in the blood serum of all animals was higher than the minimum protective level. So, the vaccine «Rabistar» provides 100 % protection of all vaccinated animals against infected lethal dose of street rabies virus. The results indicate the feasibility of incorporation of adverse animal welfare during rabies vaccination.