Analysis of the Effectiveness of Antihypertensive Drug Therapy with a Prostaglandin Series and the Correlation of Tolerant Intraocular Pressure and Biological Age in Patients with Primary Open-Angle Glaucoma
Purpose of the study - to assess the effectiveness of antihypertensive therapy with a prostaglandin-type drug Trilactan and the correlation between tolerant intraocular pressure and biological age in patients with primary open-angle glaucoma (POAG). Material and methods. The study involved 60 people, mean age 59,4 ± 7,6 years, with a diagnosis of POAG stage 2 and a degree of compensation a-b (according to the Nesterov - Bunin classification). Patients of the 1st group were diagnosed with POAG for the first time and were prescribed Trilactan once a day. Patients of group 2 with newly diagnosed POAG received the original drug latanoprost once a day. Patients of the 3rd group, who had previously received a beta-blocker drug (timolol 0,5%) 2 times a day, were transferred to monotherapy with Trilactan. The level of intraocular pressure (IOP) and morphometric parameters, the presence of side effects were determined at the start of the study, as well as after 1 week, at 1 and 3 months of the study. The calculation of the value of the tolerant IOP was carried out according to the formula developed by S.V. Balalin. The biological age of patients was measured by a complex of functional and psychological indicators based on the method of A.V. Tokar. The correlation between the indicator of biological age and the indicator of tolerance pressure in patients of both sexes was assessed. Results. The drug Trilactan demonstrated a pronounced hypotensive effect in patients with newly diagnosed POAG with an average level of IOP reduction of up to 28.4%. A significant negative correlation was found between the parameters ofbiological age and tolerant IOP in females (-0,612, average correlation strength, p < 0,01) and males (-0,735, high correlation strength, p < 0,01). Conclusion. The drug Trilactan demonstrated a hypotensive effect comparable to that of the original drug latanoprost and can be recommended as a monotherapy for primary open-angle glaucoma. A significant negative correlation between the indicators ofbiological age and the average values of tolerance pressure in males and females requires a closer control ofthe progress of neuroopticopathy according to objective studies and the desire to achieve tolerance pressure values in patients characterized by an accelerated rate of aging.