DEVELOPMENT OF TECHNOLOGY AND QUALITY EVALUATION OF MEDIBOROL'S SUPPOSITORIES
Mediborol (2,6-di-isobornil-4-methylphenol) is a promising neuroprotector for treatment and prevention of disorders of cerebral circulation. The purpose of our research is the development of technology and standardization of mediborol's rectal suppositories with a dosage 0.05 g. We chose confectionary fat with the addition of emulsifier T-2 as the optimal basis by the method of equilibrium dialysis through the semipermeable membrane. The derived suppositories of mediborol are suppositories of white color, the same size, torpedo-like shape with a smooth surface, and on a cross section of homogeneous without mechanical inclusions. The melting point ranges in the range from 33 to 34 °. The deviation of the mass of the suppository from the mean value does not exceed 5%. We used the method chromatography in a thin layer of sorbent for establishment of the identification of mediborol. The assay and uniformity of content were carried out by the spectrophotometric method. Also we established that the suppositories corresponded to the all qualifying standards for this dosage form.