The correlation between the concentration of enzymes of the POL-AO system in serum and rat brain tissue
Violations of normal metabolism lead to increased generation of active oxygen forms in cells, the excess of which creates conditions for the formation of oxidative stress. For a variety of reasons, the brain is most sensitive to this condition: brain tissue is adapted to high oxygen consumption, they contain more oxidized substrate and less active antioxidant protection system. Therefore, oxidative stress can be attributed to the most significant mechanisms of neurocyte and glia damage, as it triggers pathological reactions that irreversibly damage cells and lead to the launch of genetically programmed neuronal death - apoptosis. The article presents the study of interrelationships between the concentration distribution of enzymes of POL-AO system in blood serum and brain tissue of white pedigree rats. Using Spirman, Gamma and Kendel Tau correlation coefficients it was revealed that studying the activity distribution of enzymes of POL-AO system in blood serum and rat brain tissues reliable direct correlation links of weak force between SOD activity in blood serum and rat brain tissues were revealed (Gamma = 0.12 at p ≤ 0.039282); Kendall Tau = 0.11 at p ≤ 0.039282) and the concentration of diene conjugates in rat serum and rat brain tissue (Gamma = 0.16 at p ≤ 0.007167; Kendall Tau = 0.15 at p ≤ 0.007167).