THE ROLE OF OXIDATIVE STRESS IN PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
In the mini-review the modern trends in studying the role of oxidative stress in the pathogenesis of chronic obstructive pulmonary disease (COPD) are shown. It is shown that oxidative stress occurs simultaneously with an imbalance in the protease/antiproteazy and correlated with metabolic disorders of iron. The data presented demonstrates dysregulation of the antioxidant defense at COPD. The interrelation between the development of oxidative stress and infl ammation is shown. The hypothesis devoted to the relationship of oxidative stress, chronic infl ammation and aging in the mechanism of the pathogenesis of COPD is discussed.