THE EFFICACY OF SILVER NANOPARTICLES IN THE TREATMENT OF EXPERIMENTAL TUBERCULOSIS ACCORDING TO BACTERIOLOGICAL CRITERIA
In the study, an assessment of the silver nanoparticles as adjuvant chemotherapy of experimental drug-resistant tuberculosis. A model of tuberculosis was created in white mice-males imbrogno line BALB/c. The effectiveness of treatment was assessed according to the index lesion, examination and visivamente of the pathogen from the target organs. In the treatment silver nanoparticles with an average size up 3 to 60 nm weK used. The obtained results of the index lesion indicate a higher efficacy of the nanocomposite consisting of silver nanoparticles and isoniazid. Direct microscopic index and indicators of visivamente of lung tissue and extraorally bodies also had a higher priority statistically significant value when used in the treatment of nanocomposite. Thus were established the optimal dose of the nanoparticles in the composition that provided the highest efficiency of treatment. Studies have shown that silver nanoparticles are able to potentiate isoniazid to overcome the resistance of the pathogen.