TRANSFORMATION OF GASTROPRO- TECTIVE EFFECT OF STRESS IN PROULCEROGENIC CONSEGUENCE: DEVELOPMENT OF EXPERIMENTAL MODELS
The present work was focused on the development of experimental models, in which we can observe the transformation of gastroprotective effect of stress into the proulcerogenic one. For this aim the effect chronic stress on the formation of indomethacin (35 mg/kg)-induced gastric erosion or cold restrain (10 or 6 °C)-induced gastric erosion was investigated in rats. For chronic stress rats were repeatedly restrained for 14 days daily (1 h or 4 h mild restrain or 1 h intensive restrain) and examined on day 14. Mild restraining didn’t influence on gastric mucosa. In case of intensive restrain, the protective effect of chronic stress on the gastric mucosa was found. In order to avoid the adaptation to the daily stressor of the same modality, we subjected the rats on a daily for 14 days to unpredictable stressors of various modalities. Even in the case of strong unpredictable chronic stress we observed its gastroprotective effect if the indomethacin or cold restrain (10 °C) were used as ulcerogenic factors. The proulcerogenic effect of unpredictable stress was observed only if cold restrain at 6 °C was used as ulcerogenic factor. In conclusion, the findings again support the idea about the gastroprotective effect of stress, even in regards to chronic stress and demonstrate experimental models of transformation gastroprotective effect of stress to ulcerogenic one.