Role of local immune system factors in manifestation of HPV-associated lesions of uterine neck
It is generally accepted that an important role in the genesis of cervical neoplastic changes in human papillomavirus infection plays a system of immunity in the first place, local protection of the reproductive tract of women. In this regard, we reviewed and discussed immunological parameters of cervical mucus and their role in the manifestation of pathological cervical processes associated with human papilloma virus of high carcinogenic risk person. It was found that cytomorphological forms of cervical pathology do not reflect the pathogenetic aspects of the formation of local immunity. The formation immunosuppression occurs in the early stages of low-grade cervical lesions in the group when switching squamous lesions in integrative form. Further, in the process of carcinogenesis at the stage of integrative infection increases and expands immune suppression. It is established that the character of the local immunological disorders in HPV-associated cervical pathology is particularly due to the pathogenic forms, productive and integrative stages of papillomavirus infection.