BLOOD ADIPOKINES IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE
Serum levels of leptin and adiponectin were studied in 80 patients with nonalcoholic fatty liver disease. Increase of serum leptin levels and reduced adiponectin and factor of adiponectin/leptin were observed in non-alcoholic fatty liver disease. The presence of abdominal obesity, insulin resistance, hypertriglyceridemia, and signs of mesenchymalinflammatory syndrome in patients with nonalcoholic fatty liver disease were characterized by a relatively high leptin levels and lower levels of adiponectin and the ratio of adiponectin/leptin. The combination of liver disease with hypertension and metabolic syndrome, there was an increase in blood concentrations of leptin and a decrease in the coefficient values of adiponectin/leptin. The severity of fatty liver infiltration by ultrasound is associated with altered rates of leptin and adiponectin/leptin ratio. Thus, an imbalance of hormones of adipose tissue is correlated with clinical and biochemical syndrome of nonalcoholic fatty liver disease.