PATHOGENETIC MECHANISMS OF PERINATAL DAMAGE OF THE CENTRAL NERVOUS SYSTEM IN CASE OF PRENATAL ENCEPHALITIS AT THE FOETUSESES
We studied the paraventricular zone of thalamic area of a brain of 47 foetuses with signs of prenatal encephalitis in case of the term of a gestation of 26-27 weeks in comparison with 10 healthy foetuses in case of the same term. We showed that pathomorphologic changes in brain of human fetuses of human the person in case cellularity of prenatal encephalitis are characterized by a productive and necrotic inflammation. A reduction of cellularity of paraventricular zone, increase in amount of neurons and glial cells in thalamic area, and also the cells, expressing glial fibrous protein, the increased proliferative activity of cells of paraventricular zone indicated the accelerated maturation of its cells in case of prenatal encephalitis. Reduction of number of vessels in paraventricular zone was caused by decrease in expression of vascular endothelial factor of growth and the transforming growth factor in cells.