INFLUENCE OF THE INTERFERON FORMATION INDUCTORS AND NATURAL KILLERS SYSTEM ACTIVATORS UPON CLINICAL LABORATORY DATA OF THE IMMUNE COMPROMISED PATIENTS WITH CHRONIC RECURRENT GENITAL AND URINO-GENITAL HERPES VIRUS INFECTION IN THE SAMARA REGION
Development of a new immune therapy approach to the treatment of immune compromised patients with chronic recurrent genital and urino-genital herpes virus infection has not lost its urgency. In order to study the influence the allopheron cytokine-like peptide “Allokine-alpha” has on the clinical laboratory data of the immune compromised patients with chronic recurrent genital and urino-genital herpes virus infection in the Samara Region, we have studied cell unit (CD3 +, CD8 +, CD4+, CD16+, CD22+, HLA-DR, CD25+) with flow cytofluorometry and cytokine profile (IL-2, IL-4, IL-5, IL-8, alpha -INF, gamma-INF, alpha -INF (free), alpha -TNF). Having in the recurrence period “Allokine-alpha” 1 mg subcutaneously once a day every other day (course №6) in combination with antivirus drug “Famvir” 125 mg twice a day for 5 days results in improvement of the patients’ clinical laboratory data, decrease of recurrence frequency and duration and partial elimination of immunologic defects.