The syndrome of macrophage activation in systemic juvenile idiopathic arthritis: pathogenesis and new perspectives of therapy (literature review)
The article presents the review of literature on macrophage activation syndrome (MAS) as a complication of systemic juvenile idiopathic arthritis (sJIA). The criteria for classification of this syndrome are considered, because the diagnostics and early initiation of the MAS therapy remain blurred. There is also the overview of literature data on the "cytokine storm", which leads to uncontrolled activation of macrophages and hemophagocytosis. The advanced study of the role of cytokines in the pathogenesis of MAS in systemic JIA led to revolutionary changes in the therapy of JIA and MAS. Today, the targeted biologic therapy is becoming the standard for treatment of JIA and its complications.