CHARACTERISTICS OF THE HEMOSTASIS SYSTEM IN PATIENTS WITH PURULENT-IN- FLAMMATORY DISEASES OF THE ABDOMINAL CAVITY
Studies have shown that changes in the hemostatic system in patients with purulent-inflammatory diseases of the abdominal cavity lead to some of the most common and severe complications, such as diffuse peritonitis and adhesive disease. The aim of our study is to investigate the mechanisms of changes in the hemostatic system in patients with purulent-inflammatory diseases of the abdominal cavity and substantiate the expediency of correcting the hemostatic system in these patients. The article presents the data obtained in the study of indicators characterizing the hemostasis system in patients with catarrhal appendicitis, phlegmonous appendicitis, and patients with peritonitis. We have studied the following hemostatic parameters: the concentration of fibrinogen in blood, the level of fibrinogen degradation products, “c” antithrombin activity, the activity of coagulation factor activator, activity of blood, the contents of certain hemostasis factors of peritoneal exudate obtained when draining the abdominal cavity. In the course of our study, we noted that there is a tendency of formation of fibrin deposits in patients with fibrinous appendicitis, which prevented the development of disseminated intravascular coagulation; these deposits are present in patients with peritonitis too. Based on the data analysis, we have established that patients with purulent-inflammatory diseases of the abdominal cavity have signs of hypercoagulability. Hence, knowing the basic mechanisms of hemostasis changes in these patients, it is possible to correct these changes and contribute to the prevention of peritonitis. In our study we used a preparation of fresh-frozen plasma that in case of depletion of the hemostasis factors can be used at certain stages of the disease to promote prevention of peritonitis.