CORONARY CALCINOSIS AND PSYCHOLOGICAL DISTRESS ASSOCIATION, BY THE DATA FROM ESSE-RF STUDY IN KEMEROVSKAYA REGION
Aim. To evaluate the association of coronary arteries calcinosis with personality type D, by ESSE-RF (Epidemiology of cardiovascular diseases and risk factors in various regions of Russian Federation) trial data in Kemerovskaya Oblast. Material and methods. The study has been done under the framework of ESSE-RF trial. Standard protocol was updated with personality type assessment by DS-14 questionnaire. All patients underwent quantitative assessment of coronary calcinosis with multispiral computed tomography. The data package was analyzed with Agatstone method. Two groups of patients collected: group 1 (n=231) with type D personality, and group 2 with non-D (n=1379). Results. With the evaluation of calcium index (CaI) there were significant differences in groups: 689,3±53,7 in type D patients and 546,5±47 with none (p=0,048). Moderate and severe CaI was higher in type D patients - 10,3% and 12,5% vs 5,8% and 2,9%, respectively (p=0,043 and p=0,011). Highest differences in CaI in the left coronary artery, exactly in the left anterior descending, were 189,1±12,5 in type D vs 155,6±16,7 in non-type D (p=0,011), and circumflex artery - 121,7±30,6 vs 63,8±21,7 (p=0,032). With the logistic regression, the most influencing on moderate and severe CaI were age - hazard ratio (HR) 1,07-2,14 (p=0,023), diabetes - HR 1,32; 95% CI 1,09-1,62 (p=0,032), type D personality - HR 1,42; 95% CI 1,12-1,82 (p=0,023), coronary heart disease - HR 1,12; 95% CI 1,01-1,21 (p=0,034). By the multifactorial analysis, as independent predictors of moderate and severe CI remained such parameters as coronary heart disease - HR 1,24 95% CI 1,01-1,53 (р=0,04), diabetes - HR 1,28; 95% CI 1,80-3,24 (р=0,02) and type D - HR 1,49; 95% CI 2,01-2,29 (р=0,01). Conclusion. Screening for the influence of type D personality is worthy in persons with subclinical coronary arteries lesion to conduct on-time preventive events.