Value of immunofluorescence reaction in algorithm of modern diagnosis of syphilis
The aim of the work was to study the indices of the diagnostic effectiveness of the indirect immunofluorescence (RIF) reaction for the detection of treponemospecific immunoglobulins of class G and M (IgG and IgM) in syphilis patients. Among sexually transmitted infections (STIs), syphilis is characterized by the most severe clinical manifestations with the defeat of almost all systems of human organs, which significantly reduces the quality of life of the patient and often pose a danger to his life. The immunofluorescence reaction is currently one of the most sensitive and demanded studies for diagnosing syphilis. The RIF is highly sensitive at all stages of an actively developing infection, beginning with the incubation period (RIF-IgM variants) and ending with late syphilis. The study in the RIF with the ‘Antipallidum-Fluorogen-IgM/IgG’ kits can be used as confirmatory tests for latent syphilis, as an expert method.