Proneness to thrombognesis in the case of patients having mesenchimal dysplasia and vascular malformations against the background of preparedness to hemorrhage
This article describes a study that found a hidden tendency to thrombosis in patients with manifestations of the vascular syndrome with mesenchymal dysplasia. The study found that in patients with connective tissue dysplasia, alongside a tendency to bleeding, found the tendency to thrombs formation due to the moderate thrombinemia, activation of coagulation factor VIII. It is shown that in the investigated patients revealed high frequency of mutations and polymorphisms in the genes of the hemostatic system, by a number of parameters exceeding the incidence in the General population, indicating a predisposition to thrombophia. The obtained data allows to speak about thrombogenic potential of blood in patients with vascular malformations in connective tissue dysplasia.