Comparative analysis of diuretics effectiveness in arterial hypertension therapy in women. The results of AFINA trial
The AFINA trial included 2,862 women with arterial hypertension (AH). Only 6% of them controlled their blood pressure (BP < 140/90 mm Hg). It was related to use of diuretics, and one of them - original indapamide retard; corrected odds ratio (OR) was 1.86 (95% confidential interval 1.11 - 3.12). Addition of Arifon retard to the therapy scheme of women with uncontrolled AH resulted in decrease of BP in 12 weeks on 31 ± 14 /15 ± 9 mm Hg. This effect was more significant in Arifon retard group then in women, receiving hydrochlorthiazide (HCT) or thiazide-like diuretic (TLD) with usual release. Such result of treatment was obtained in conditions of more frequent mono therapy in Arifon retard group (18%), while treatment with HCT or TLD with usual release often included three medications. Effectiveness and tolerance to therapy, including Arifon retard, in women with uncontrolled AH, was estimated by the specialists as better way than arbitrary treatment with HCT or TLD. Besides, authors proved that administration of Arifon retard resulted in decrease of risk of handling to an emergent medical aid two times lower than a treatment with other diuretics.