CHARACTERISTICS OF ACTOPROTECTIVE ACTION OF AMINOACIDS DERIVATIVES OF 1,4-NAPHTHOQUINONE UNDER CONDITIONS OF HYPO- AND HYPERTHERMY
It was shown in experiments on the rats that after unitary intraperitoneale introduction of aminoacids derivatives 1,4-naphtoguinone (substances III - 10,2 mg/kg and VI - 7,4 mg/kg) as a bemithylum (34 mg/kg) into organism physical endurance of animals (swimming test) rises under hyperthermic conditions (38-40 °С) on 61,7; 83,6 and 48,7 % and under hypothermic conditions (10-12 °С) rises on 39,2; 46,0 and 51,6 % (p < 0,05) accordingly. Such action of these compounds indicates that they have actoprotective effect. Compound VI, contains in its structure a glycine residue, is interested for inepth study of its actoprotective properties and mechanisms of action.