Salivadiagnostics in patients with juvenile rheumatoid arthritis
The aim of our research was studying the physical and immunohormonal characteristics of the oral fluid in patients with JRA. A decrease of the rate of salivation and an increase in the viscosity of oral fluid have been established. In the coordination of cortisol-ACTH, there was a disturbance in the balance in the form of an increase in the content of cortisol in 2,86 times and a decrease in ACTH in 0,62 times. The cytokine profile was characterized by the state of immunodeficiency with a decrease in the concentration of IL-1β - in 2,07 times, IL-6 - in 1,83 times, TNF-α - in 2,08 times, IL-4 - in 0,58 times, IL-10 - in 4,26 times. These indicators showed a correlation interdependence, as well as the conjugation with the index of caries intensity.