Stem cells of glioblastoma
The review describes the immunophenotypic properties of the stem cells of glioblastoma and their role in tumor growth. Glioblastoma is a heterogeneous tumor which regions differ in proliferative activity, features of angiogenesis and secondary changes caused by inconsistent microenvironment. Stem cells of glioblastoma may vary in phenotype and metabolism depending on their regional location, that ensures their resistance to chemotherapy and radiotherapy and contributes to the invasive growth of the tumor. Elimination of stem cells of glioblastoma may be a promising method for the treatment of glioblastoma. Therefore, a search for markers of stem cells of glioblastoma is conducted in order to develop targeted therapy.