Features of endocrine and metabolic changes in women with hyperandrogenia of various genesis in reproductive period
The features of endocrine and metabolic changes in women with hyperandrogenia in reproductive period are considered. It was determined, that women with hyperandrogenia of various genesis had significant increase of the ratio of luteinired hormone to follicle stimulating hormones, increase of 17-oxyprogesterone, testosterone, androstendione, dehydroepiandrosterone sulfate, as well as indices of insulin resistance and Caro on an empty stomach and after oral glucose tolerance test. The pathogenetic therapy of the pathologies that inducted hyperandrogenia, allowed significantly to reduce the indicators of the ratio of luteinired hormone to follicle stimulating hormones, prolactine, thyroid stimulating hormone, estron,17-oxyprogesterone, androstenedione, dehydroepiandrosterone sulfate, glucose, insulin, as well as indices of insulin resistance and Caro on an empty stomach and after oral glucose tolerance test and allowed to increase the indicators of estradiol, free thriidothyronine, sex hormone binding globuline. The study of metabolic processes of patients with hyperandrogenia of various genesis confirmed high levels of insuline after the glucose challenge test, homeostasis model assessment of insulin resistance index, Caro index. In general, carried out complex pathogenetic therapy of pathological conditions and diseases which cause hyperandrogenia significantly alters indicators of hormones and carbohydrate metabolism.