STUDY OF VLPS IN A MOUSE MODEL OF SECONDARY BACTERIAL PNEUMONIA FOLLOWING INFLUENZA VIRUS INFECTION
In a mouse model of secondary S. aureus and S. pneumoniae pneumonia following influenza virus infection was studied virus like particles with hemagglutinin of influenza virus protective properties and antigenic activity. Vaccination with this VLPs caused the formation of antibodies, protects animals from death, reduce weight loss. VLPs antigenic activity was dose dependent and vaccination multiplicity. Protective properties of vaccination properties depended only on VLPs dose.