Investigation of analgesic and anti-exsudative activity of ammonia salts substituted imidazo-[1,2-f]xanthinyl-8-propionic acid
Screening investigations of ammonia salts substituted of imidazo[1,2-f]xanthinyl-propionic acid have been conducted and their influence on inflammatory process and sensitiveness of visceral nociceptors have been studied. As a result of experimental research of analgesic activity the compound 4 has been exposed, possessing analgesic action comparatively with activity of diclofenac. The compound 4 also has shown anti-exudative activity practically on the level of diclofenac. Ammonia salts substituted of imidazo[1,2-f]xanthinyl-propionic acid are the perspective group for further synthesis and search of new pharmacological substances with analgesic and anti-inflammatory abilities.