Alloimmunization to neutrophil antigens in patients with hematology/oncology disorders
The analysis of the level of alloimmunization to neutrophil antigens (HNA) in hematological patients is presented. Different mechanisms and associated complications are discussed based on literature data. Frequency of detection of alloantibodies to HNA antigens in oncohematological patients was 3,17 %. Highest immunisation levels were detected in patients with aplastic anemia (16,7 %) and hemophilia (10,7 %). Anti-HNA antibodies in patients with hemoblastosis were detected in 1,8 %-4,6 %.