Effectiveness of use of mesenchymal stem cells of the adipose tissue for skin defect restoration in experiment
The purpose of this study was to evaluate the effect of adipose tissue-derived mesenchymal stem cells (AD-MSCs) for skin restoration in a rat model. Sixty rats were randomly divided into three equal groups; control and experimental (autologous and allogeneic AD-MSCs). AD-MSCs were applied to the wound surface of animals of the experimental groups. Full thickness skin samples were taken from the wound sites for the morphological study on the 30th day after transplantation. It has been established that the AD-MSCs enhance the rate of restoring the integrity of the skin via various mechanisms.