Experimental study of the functional state of reproductive system male white rats on exposure p-nitrophenol
We studied the functional condition of the sexual glands of male rats exposed by p-nitrophenol - a toxic product of the decomposition of organophosphorus compounds. We investigated the gravimetric data testicular morphological and morphometric parameters seminiferous epithelium of rats. It is found that the experimental animals treated with p-nitrophenol in 14 days daily subcutaneous dose of 1 mg / kg and 10 mg / kg, there was a sharp decrease in the index of spermatogenesis reflecting disorders maturation of sperm, reducing the number of rows of germinal cells and area of epithelium of convoluted seminiferous tubules. Indicators sectional area of spermatogenic cells showed a slight increase in the formation of the nuclei of spermatogonia and spermatids in the group of animals inoculated at a dose of 1 mg / kg, and a significant decline in the 10 mg / kg. Morphometric measurement of Leydig cells showed that the size of kernels increases as the concentration of fluorine and 10 mg / kg, significantly higher than normal. Thus, the effect of low doses of p-nitrophenol on fertility of male albino rats leads to a dose-dependent morphological changes in the seminiferous epithelium and leads to changes in endocrine function of sexual glands.