THE INFLUENCE OF DEHYDROISOANDROSTERONE ON INDICATORS OF BRAIN CORTEX DEVELOPMENT IN NEWBORN RATS
The authors studied the indexes of brain development of albino rats who wrer introduced oil solution of dehydroisoandrosterone (DHAS) at the age of 1 day. The control brains were introduced the solvent. Hormone introduction resulted in brain development changes. There were tendencies to brain mass increase, reliable increase of hemisphere mass, parietal proper lobe (PPL) cortex became thicker, as well as the I layer of the supraparietal lobe (SPL). SPL cortex neurons in the experimental rats had a smaller nuclei in the layer II, nuclei and nucleoli in layer V. Nuclei size and hippocampus neurons cytoplasm were larger than in the control. PPl cortex neurons did not have reliable intergroup changes. RNA concentration in plasma in all the studied locations did not reveal any significant differences. Activity of NADN-dehydrogenase in neuron layer II in rats having received DHAS was higher than in the control group. This enzyme activity in neurons of other localizations as well as NADFN-dehydrogenase and 3β-hydroxysteroiddehydrogenase in the studied cerebral neurons did not demonstrate any significant changes between the two groups.