Lupus nephritis as a topical problem of pediatric nephrology. Clinical case of lupus nephritis class I in a child with nephrotic syndrome
Systemic lupus erythematosus is a chronic autoimmune disease accompanied by the synthesis of autoantibodies and the deposition of complement-fixing immune complexes in damaged tissues and organs. Systemic lupus erythematosus has many clinical manifestations, with kidney damage, the so-called lupus nephritis, being one of the most dangerous. The problem of lupus nephritis is especially relevant in pediatric practice, since it is believed that in children the disease is more severe than in adults and is often associated with infant mortality. This article presents modern ideas about the pathogenesis, clinical picture, and therapeutic tactics for lupus nephritis, as well as a clinical observation of class I lupus nephritis occurring with lupus podocytopathy