Frequency of chromosomal aberrations in lymphocytes of peripheral blood in patients with solid tumors
There was carried out a study to compare the frequency of spontaneous chromosomal aberrations (CA) in lymphocytes of peripheral blood between the group of cancer patients with different types of solid tumors and the group of healthy people of the same age. There was established a significant increase in the average frequency of CA in cancer patients. Analysis of the group of patients has revealed its heterogeneity: in the majority of patients the individual frequency of CA significantly exceeded the average frequency of CA in the control group, in some - did not differ from that. The first patients were described as the group with "generalized" genomic instability. Also this group differed by increased radiosensitivity of lymphocyte chromosomes during their irradiation in vivo.