THE STATE OF VASCULARIZATION OF THE ILEUM AGAINST THE BACKGROUND OF INTRALUMINAL HYPERTENSION, CAUSED BY TRANSIENT MYOCARDIAL ISCHEMIA
Two series of experimental research were conducted in order to study the state of intramural vascularization against the background of intraluminal hypertension caused by transient myocardial ischemia. In the first series of the experiment, the dynamics of intraluminal pressure (ILP) in the ileum was studied on 10 animals after modeling of experimental transient myocardial ischemia (ETMI) for 30 minutes. In the second series, with the use of 10 animals after ETMI, within 30 minutes in the postoperative period, the study of the dynamics of ILP was carried out against the background of permanent blockade of retroperitoneal nerve formations in the zone of transition of the ileum to the colon. After that, in the lumen of the ileum, intraluminal hypertension was modeled, corresponding to the maximum level of pressure in the postoperative period. The drugs were registered by the conventional method with Van Gieson staining. The vessels were counted using stereometric morphometry of Avtandilov's grid in 50 fields of view in each preparation. The criteria for the analysis were as follows: the total number of vessels, the number of active and inactive vessels and their ratio. It was found that against the background of increased intraluminal pressure, there was a significant decrease in the total number of active vessels, which indicates its role in the violation of intramural microcirculation of the ileum. At the same time, permanent blockade of the ileum-to-colon transition zone reduces the risk of microcirculatory disorders in the ileum wall.