ADHESION MOLECULES OF MULTIPOTENT MESENCHYMAL STROMAL CELLS OBTAINED FROM ADIPOSE TISSUE DURING SIMULATION OF THE EFFECTS OF MICROGRAVITY
Multipotent mesenchymal stromal cells (MSCs) are mechanosensitive cells capable to react to a changed gravity and to influence other types of cell. One of the structures mediating cell mechanosensitivity is cell adhesion molecules. To study the effects of modeled microgravity, monolayers of human adipose-derived MSCs were positioned at random relative to the vector of adhesion molecules. According to our results, 96-hr cells exposure in modeled microgravity reduces quantities of such surface antigens as CD105, CD51/61, CD44 and CD54, and alters the transcription activity of several genes associated with adhesion and extracellular matrix. These effects can underlie the modulation of stromal cells functioning in micro-g environment.