SOME ASPECTS OF CARDIOMYOCYTE APOPTOTIC CELL DEATH IN HYPERTENSION OF DIFFERENT TYPES
Investigations of the dynamics and induction of cardiomyocyte apoptotic cell death in spontaneously hypertensive rats and rabbits with vasorenal hypertension were summarized in this article. It was found that cardiomyocyte apoptosis rate in the left and right ventricles significantly increased under hypertension and caspase independent mechanisms were predominant in its implementation. Energy deficiency in myocardial cells is one of the factors inducing apoptotic cell death in vasorenal hypertension. Energy deficiency is also the main trigger of apoptotic processes in the left ventricle of spontaneously hypertensive rats, but extrinsic pathway is activated by oxidative stress. One of the factors facilitating to predominance of apoptotic inducers is endothelin-1. Inducers of myocardial cell apoptosis in the right ventricle differ from those in the left ventricle and should be further investigated.