THE ROLE OF MITOCHONDRIAL DYSFUNCTION IN THE DEVELOPMENT OF PLACENTAL PATHOLOGY
The review examines the role and mechanisms of participation mitochondrial dysfunction in the pathogenesis of several human diseases, including and in the pathology of the placenta. The linkage mechanisms of mitochondrial dysfunction with the structure and organization of mitochondrial genome are underscored. It is shown that the increase in production of reactive oxygen species in mitochondria placenta leads to the depletion of the individual units of antioxidant protection and the development of systemic oxidative stress of the body, accompanied by the development of placental insufficiency-tare.