THE STATE OF LIPID METABOLISM IN THE INITIAL PERIODS OF MYOCARDIAL INFARCTION IN MEN YOUNGER THAN 60 YEARS WITH METABOLIC SYNDROME
Features of lipid metabolism in myocardial infarction in men with metabolic syndrome have not been studied enough. The main purpose of the study: to evaluate the state of lipid metabolism in men younger than 60 years old with metabolic syndrome and myocardial infarction in order to find possible ways to improve preventive practices. The study included men aged 19-60 with type I myocardial infarction. Patients were divided into two age-comparable groups: I - those with metabolic syndrome - 95 patients; II - participants without it - 571 patients. A comparative assessment of lipid metabolism was performed. The results after the first 48 hours were compared to the ones at the end of the third week of myocardial infarction in the chosen groups. It was found that in the first hours of myocardial infarction in the study sample, higher levels of triglycerides were noted (3.19 ± 2.34 in the study group and 2.44 ± 1.75 mmol/l in the control group; p = 0.02). In the study of lipid indicators in a thorough analysis, multidirectional changes in parameters with a more pronounced atherogenic potential in the study sample were revealed. When evaluating the correlations of the prognosis and patients’ life quality parameters, the most significant were obtained for the coefficient and index of atherogenicity. Conclusion. Metabolic syndrome slightly worsens lipid parameters in both acute and subacute ending period of MI. Multidirectional dynamics and interrelations of lipid parameters with indicators of disease prognosis and quality of life are noted. The coefficients and indices of atherogenicity appear to be more stable and sensitive in relation to the life quality of individuals.