Clinical and epidemiological patterns of papilloma virus infection among dermatovenerological patients
Incidence of cervix cancer is increasing, number of cases rose considerably in the age group 20 - 59 years. Incidence of genital warts in the Karelia Republic increased 3 times in 2004-2006 in comparison to 1995. Aim of the study was to describe pattern of human papilloma virus infection among dermatovenerological patients on the territories of the North-West Russia. There were 2055 patients tested by PCR for oncogenic human papilloma viruses (HPV) of types 16, 18, 31, 33, 35, 45, 56 in 2002-2007. Prevalence of high oncogenic risk HPV per 100 tested was 34,6±1,8 in Saint-Petersburg and 31,9±1,3 in the Karelia Republic. Proportion of HPV types 16 and 18 among all HPV viruses was 58,0±5,9%. Co-infection of HPV type 16 and type 18 was revealed in 4,4±2,1%. Co-infection of HPV with gonorrhea was seen in 50,7±6,1%, with chlamydia infection - in 62,1±9,0%. Patients without clinical signs of sexually transmitted diseases were positive for HPV in 34,9±6,0%. Patients at the age 20 - 29 (52,6±3,0%) and 15 - 17 (36,8±4,6%) years were the most affected age groups by HPV infection. Patients with 10 and more sexual partners from the start of their sexual debut had HPV infection in 77,1±7,1%, those with one sexual partner - in 26,5±6,3% (p<0,01). Prevalence of oncogenic HPV among pregnant women was 16,1±3,8 per 100 tested. In 20% of all cases treated oncogenic HPV was revealed 3 months after treatment course fulfillment. Study results prove the necessity to establish system for epidemiological surveillance and prevention of human papillimavirus infection.