Genes Polymorphism of Toll-Like Receptors as Predictors of Tuberculosis Development and Its Course
Polymorphisms in genes of the innate immune factors have a decisive influence on the occurrence, development and outcome of infectious disease. As the analysis of the literature showed the results of studies of the susceptibility to tuberculosis in different populations are diverse and sometimes contradictory. Their systematization allowed identifying several gene polymorphisms of TLR, looking for further study and possible use as predictors of the development and course of tubercular process. We have considered that polymorphisms of TLR2 rs5743708 (2258G / A genotype) and TLR1 rs4833095 (743A / G genotype) are interesting for further study. The first is the polymorphism of "promoting" the development of the disease. The second can be attributed to "hindering" the pathological process by influencing the functional activity of receptors of innate immunity. Researches of the contribution of TLRs genetic polymorphisms in susceptibility to tuberculosis process in general and to its various forms, including MDR can be very useful for individualization of treatment.