PATHOMORPHOLOGICAL PICTURE OF A NEW EXPERIMENTAL MODEL OF MIXED URATE-OXALATE NEPHROLITHIASIS
The article presents a description of the pathomorphological picture of a new experimental model of urate-oxalate nephrolithiasis. 43 Wistar rats were used as a biological system. Modeling of the disease was carried out for 21 days by a combination of traditional methods of modeling urate and oxalate nephrolithiasis. After ether euthanasia, the kidneys of laboratory animals were taken, followed by sectioning to study the number and area of renal calculi, as well as the general pathological state of the renal tissue. According to the results of the study, the main pathomorphological signs of mixed urate-oxalate nephrolithiasis were identified: the formation of renal deposits, the phenomena of nephrosclerosis, as well as inflammatory and dystrophic changes in the tissues of the kidneys.