EXPERIMENTAL RESEARCH OF THE ANTIBACTERIAL ACTION OF NICKEL NANOPARTICLES ON THE CLINICAL STRAINS PSEUDOMONAS AERUGINOSA
The present time is characterized by the prevalence of gram-negative microflora in the structure of a purulent infection, blue pus bacillus (Pseudomonas aeruginosa) deserves a special attention. A quick forming of the resistance in the course of treatment is a characteristic property of Ps. aeruginosa. It dictates the necessity of searching new antimicrobial preparations. In this respect metals in the form of nanoparticles are one of the prospective pretenders to the creation of a new class of the antimicrobial preparations. Antibacterial activity of nickel nanoparticles regarding clinical strains Ps. aeruginosa is studied experimentally. Evident bactericidal effect of the superdispersed powder of the metal concerning blue pus bacillus strains is detected. Antimicrobial action of nickel nanoparticles regarding the microorganism under study – concentration and period of the action relationship is determined. A slight increase in saccharolytic activity of Ps. aeruginosa strains after the action of the metal nanopowder is observed. Proteolytic activity of the tentative strains is studied as well; changes after action of the nanoparticles is not detected.