EFFECT OF CURCUMIN AND GLIOTOXIN ON FIBROBLASTS FROM THE LARGE PORTAL TRACTS OF RATTUS NORVEGICUS
In recent years there were lots of researches focused on inhibiting connective tissue cells in the liver of patients with chronic hepatitis. Most studies of the substances which can potentially be considered as drugs for the treatment of liver fibrosis were performed on hepatic stellate cells. However, there is a theory of portal fibroblasts participation in liver fibrosis, as in most cases the processes of fibrogenesis start both at main portal tract and intrahepatic ducts. Suppression of fibrogenesis by preventing the activation and induction of apoptosis of portal fibroblasts are being considered as therapeutic strategies for the treatment of liver fibrosis.