Functional activity of the pituitary-adrenal system and IL-1α, TNF-α, content in patients with the original high vegetative reactance in the preoperative period and their correction
Objectives. To study changes of the functional activity of the pituitary-adrenal system and IL-1α, TNF-α content in the preoperative period in the patients with high vegetative reactance and to estimate the efficacy of their correction with diazepam. Methods. 57 patients hospitalized for the planned operation were investigated. The vegetative status was characterized by the vegetative indexes, level of ACTH and cortisol was determined by RIA method, the cytokines content was determined by ELISA. Results. In the preoperative period in the patients with high vegetative reactance on the background of parasympathetic impact activation, decrease of the vegetative reactance and increase of ACTH content the parameters of IL-1α, TNF-α reduced. On the background of diazepam injection in such patients during two days of the preoperative period the sympathetic activity increased, ACTH and cortisol content decreased; this contributed to IL-1α increase and TNF-α decrease. Conclusions. Injecting diazepam to the patients with high vegetative reactance during two days of the preoperative period prevents the development of maladjustment contributing to IL-1α synthesis.