Antioxidant Properties of Aminothiol and Triazinoindol Antihypoxants
The antihypoxic activity of 6 aminothiol and triazinoindol derivatives was studied in a model of hypobaric (hypoxic) hypoxia in rats. The range of antihypoxic activity was the following: amtizol succinate ≈ amtizol ≈ gutimin > Т-475 > > gutimin succinate > succinate. One of the mechanism of action for all antyhypoxants was the inhibition of lipid peroxidation and recovery of hypoxia-induced antioxidant defense system in the brain, kidneys, hepar, heart and muscles (the reduction of the contents of malonic dialdehyde and lipid hydroperoxides, the increase of superoxid dismutase activity and the contents of recovered glutation). Amtizol revealed the most antihypoxic activity. It recovered all negative shifts produced by middle and heavy hypoxia in the organs studied. Succinate did not potentiate antihypoxic and antioxidant properties of amtizol. Gutimin inhibited the activation of lipid peroxidation preventing the increase of malonic dialdehyde and lipid hydroperoxides and the decrease of recovered glutation produced by hypoxia in all organs studied. Besides, gutimin inhibited both superoxid dismutase and catalase activity. Gutimin succinate strengthened the inhibitory action of gutimin on lipid peroxidation and prevented its inhibitory effect on superoxid dismutase activity in all organs studied.