The INFLUENCE OF MELATONIN ON PATHOHISTOLOGICAL CHANGES OF INTERNAL ORGANS while THE EXPERIMENTAL AMYLOIDOSIS
In this work the data of research about the influence of melatonin melaxen preparation on the character of morphological changes of internal organs are submitted while experimental amyloidosis. It is revealed, that melatonin renders a positive effect shown in the decrease of accumulation of amyloid in organs and tissues on the model of experimental amyloidosis, induced by the introduction of native egg albuminum to the syrian hamsters. Melatonin blocks an opportunity of cell transformation of macrophagal-endothelial systems in amyloidoblastes and reduces the intensity of amyloidogenesis. Rendering antioxidant action, melatonin promotes stabilization of cellular membranes, reduces the damage of endothelium of vessels and the formation of plasma component of amyloid.