Modern ideas about the etiology and pathogenesis of primary open-angle glaucoma (POAG) from the position of regularities of the general pathological process (Literature review)
The article presents an overview of recent studies on various aspects of the etiology and pathogenesis of primary open-angle glaucoma. The modern concepts of the pathogenesis of glaucoma are described from the point of view of the violation of the adaptive mechanisms opposing the involution processes. The arguments in favor of a systemic view of glaucoma from the point of view of the integrity of the organism are given, which allows to reveal the interrelation of chronobiological, functional, structural and metabolic disturbances in POAG, the conjugacy of these changes and their contribution to the progression of glaucoma optic neuropathy. The mechanisms of the formation of the primary open-angle glaucoma as a system dysregulatory process are analyzed, at which adaptive processes of different levels are violated: from the lower: molecular, cellular and tissue to higher, controlling the work of the whole organism.