Current concepts on the pathogenesis of bronchial asthma and obesity in children
Bronchial asthma and obesity are a serious medical and social problem worldwide and its combination significantly decreases the quality of life of such patients, requires comprehensive treatment, and is associated with substantial economic losses. The incidence of bronchial asthma complicated by obesity in children is constantly increasing. This literature review summarizes current views on asthma pathogenesis in obese patients. It covers the main phenotypes of asthma associated with obesity in adults and children and focuses on the role of mechanical factors in disease pathogenesis, as well as the impact of systemic and local inflammation, oxidative stress, and metabolic changes, including hyperglycemia, hyperinsulinemia, and insulin resistance,