FEATURES OF APPLICATION OF VARIOUS INTRAUTERINE CONTRACEPTIV AT WOMEN WITH BACTERIAL VAGINOSIS IN THE ANAMNESIS
The purpose of research is studying of a qualitative and quantitative composition of vagina and endometrium microflora and morphological changes at women with bacterial vaginosis in the anamnesis, who using various kinds of intrauterine contraceptiv. Depending on medical indications and desire of the woman, copper intrauterine contraceptive (30 women - 1-st group) or levonorgestrel-relising intrauterine contraceptiv (34 women - 2-nd group) was used. The character of aerobic and unaerobic microflora in vagina and uterus cavities at observable women have studied. <i>Chlamida trachomatis, mycoplasmas, ureaplasmas, </i>CMV, HVS, HPV infections in endometrium and cervical chanal were detected by PCR method. The morphological research of endometrium was carried out to the majority of women after removal of intrauterine contraceptiv. The received results have compared to bacteriological and morphological data of 20 women with bacterial vaginosis without intrauterine contraceptiv (group of comparison) and 7 healthy women (group of the control). Statistical processing of results is lead with use of the regressive-dispersive analysis by means of program Statistica 6.0 for the personal computer. It is established, that bacterial vaginosis promotes development of contamination of endometrium. Thus copper intrauterine contraceptive prevents contamination of uterus cavity only within first three years. The increase in term of copper intrauterine contraceptive using leads to frequent recurrents of bacterial vaginosis, obligatory contamination of endometrium, first of all, <i>Enterococcus sp. </i>and <i>Ureaplasma urealyticum. </i>Development of chronic endometritis is observed at 35 % and hyperplasia of endometrium at 60 % of women. Levonorgestrel-relising intrauterine contraceptive development of pathogenic and opportunistic microorganisms in endometrium, on the contrary, brakes. Possible it prevents recurrences of bacterial vaginosis, development of endometritis and hyperplastic processes of endometrium.