COMPARATIVE EXPERIMENTAL-MORPHOLOGICAL RESEARCH OF LIGHT AND LIGHT STRENGTHENED ENDOPROSTHESIS FOR HERNIOPLASTY
Objective. To study the changes of anterior abdominal wall tissues in experimental animals with implantation of new light strengthened endoprosthesis for hernioplasty. Methods. Experimental studies were conducted on 60 rabbits of “Chinchilla” breed. All animals were divided into 2 series of experiments. In the first (control) group animals were implanted with a light polypropylene endoprosthesis, in the second (experimental) group animals were implanted a new net endoprosthesis from monofilament polypropylene, which consisted of the basic and strengthened zones in the form of horizontally located stripes, alternating with each other mono-thread with a larger diameter. In the experiment the tissue response of abdominal wall with implantation of endoprosthesis in the position “onlay” was studied on the 7<sup>th</sup>, 30<sup>th</sup>, 60<sup>th</sup>, 90<sup>th</sup> and 180<sup>th</sup> days. Results. It was found out, that the light strengthened endoprosthesis was identical to the light endoprosthesis by the severity and amount of inflammatory response in late periods (90 and 180 days), as well as by cellular structure and cellular index, reflecting the character of wound process during the whole experiment (from the 7<sup>th</sup> till 180<sup>th</sup> day). Histological study showed that the use of the both materials does not lead to deterioration of morpho-functional condition of the muscle layer of the abdominal wall. Using morphometrical study from the 7<sup>th</sup> till the 30<sup>th</sup> days we detected that cellular infiltration area decreased by 3.9 times in a control group and by 4.1 times in an experimental group. From the 30<sup>th</sup> till the 180<sup>th</sup> days the size of the capsule area increased by 1.6 times in a control and by 1.2 times in experimental series. At late periods (on the 90<sup>th</sup> and 180<sup>th</sup> days) statistically significant differences of all these indicators between the series of experiment were not detected. Conclusions. Introduction of the strengthened zone to the structure of the light endoprosthesis, including monofilaments of the larger diameter, does not lead to deterioration of abdominal tissue response to the implanted material, that presents prospective for its use in hernioplasty. What this paper adds The reaction of abdominal wall tissues for implantation of light strengthened endoprostheses for hernioplasty has been studied for the first time. It has been established that according to the severity of the inflammatory reaction, the light strengthened endoprosthesis, if compared to light material, does not differ. Introduction of the strengthened zone to the structure of a light endoprosthesis which includes a monofilament of greater thickness, does not worsen the reaction of abdominal wall tissues to the implanted material.