THE ESTIMATION OF 3-OXIPIRIDINACETYLCISTEINATE AND AMBIOL INFLUENCE ON THE LIPID PEROXIDATION PROCESSES AND MORPHOFUNCTIONAL CHANGES IN THE LIVER OF MICE WITH THE LEWIS LUNG CARCINOMA AGAINST THE BACK GROUND OF CYCLOPHOSPHAMIDE THERAPY.
It is shown that 3-oxipiridinacetylcisteinate and ambiol reduce the activity of lipid peroxidation in the blood serum and reice the antioxidant status of the liver tissue, hereat this influence is more effective in a dose 25 mg/kg. Ambiol and 3-oxipiridinacetylcisteinate render a hepatoprotective effect, reducing, hereat, necrobiotic and dystrophic changes in hepatocytes. The antioxidants studied in the analised doses do not reduce the antineoplastic effect of cyclophosphamide with respect to a primary tumoral knot, and in the 25 mg/kg dose they raise, antimetastatic efficiency of the cytostatics.