FUNCTIONAL ACTIVITY OF TH17-LYMPHOCYTES AND REGULATORY T-CELLS IN CHILDREN WITH INFLAMMATORY BOWEL DISEASE
The results of Th 17-lymphocytes and regulatory T-cells mitochondrial activity investigation in children with inflammatory bowel disease, treated by anti-TNF-a therapy, are presented in the article. Elevated Th17-lymphocytes number, increasing during the first year of biological therapy, along with decreased mitochondrial activity in this subsets, were revealed in patients with nonsustained effect of infliximab. These patients also had features of mitochondrial dysfunction in regulatory T-lymphocytes. Children with sustained effect of biological therapy were characterized with increased mitochondrial activity and elevated number of regulatory T-lymphocytes before the treatment, with following increaseof this subset size during the first year.