Spontaneous and stimulated in vitro production of the main proinflammatory cytokines of blood mononuclear cells at an ischemic stroke
Ratios of IL-17A, IL-1; TNF-α;and IL-4 in serumal samples, supernatants of intact and stimulated in vitro PHA of peripheral blood mononuclear cells at patients with an ischemic stroke (n=10) and unrelated donors without clinical implications and heriditary burdeness of cardiovascular diseases (n=12) authentically differ (Р<0,05) in three cytokines: IL-17A, IL-1, and TNF-α. At patients with an ischemic stroke, unlike donors, serumal concentrations of IL-17A, levels of spontaneous and stimulated PHA of production IL-1; TNF-α are statistically significantly (P≤0,05) increased. The contents of IL-4 in the studied biological media do not exceed 0,25 pg/ml and have no reliable differences for all examined groups (Р>0,05).