RESULTS OF THE PILOT STUDIES DIRECTED ON THE ASSESSMENT OF BIOLOGICAL PROPERTIES OF THE MODIFIED ZIRCONIUM DIOXIDE GRANULES
Materials for production of dentures and implantation systems have to possess a complex of characteristics among which lack of toxicity in relation to tissues of the patient and bioinertness is obligatory. The purpose of work was development of ceramics on the basis of zirconium dioxide with a further assessment of parameters of acute toxicity, and also research of influence on regeneration of a bone tissue. For the solution of objectives the ceramics on the basis of zirconium dioxide stabilized the 15th pier was developed and received. % cerium dioxide. By results of experiment of an assessment of parameters of acute toxicity it is established that zirconium dioxide nanoparticles in a dose of 8000 mg/kg at single probe introduction don’t cause intoxication phenomena on the level of change of integrated indicators of the general condition of experimental animals. Results of histologic research of tissues of experimental animals revealed dense contact of a coarse-fibered and lamellar bone tissue with porous granules of dioxide of zirconium. Modifying of a surface of granules compounds of calcium and phosphorus, promotes effective process of a reparativny histogenesis of a bone. It provides dense connection with it without signs of development of pathological changes of fabrics in a zone of an arrangement of the implanted material. Thus, there is a possibility of application of granules of dioxide of zirconium in practical stomatology for acceleration and improvement of quality of bone regeneration at a sine lifting with direct installation of a tooth implant; for elimination of defects, a bone tissue, adjacent to an implant, by sealing of bone defects; for building or reconstruction of a bone tissue of maxillofacial area with preservation of high degree of esthetics.