INSUFFICIENT EFFICIENCY OF STANDARD TREATMENT IN CORRECTION OF IMMUNOMETABOLIC DISTURBANCES AT THE CHRONIC CATARRAL GENERALIZED ULITIS, THE GENERALIZED PERIODONTAL DISEASE AND THE DONTOGENOUS OSTEOMYELITIS OF MAXILLOFACIAL AREA
In a blood plasma, more in washout from a desnevy pocket of patients with a chronic catarral generalized ulitis and a chronic generalized periodontal disease the picture of an immune inflammation characterized by an imbalance of cytokines, components of system of a complement, pro- and the antioxidant mechanisms, directly depending on degree and prevalence of pathological process develops. At an acute dontogenous osteomyelitis of maxillofacial area similar changes of immunometabolic indicators at systemic and local level are observed, but distinctive feature are maximum levels of chemoattractants of cells of effektor, in particular, IL-8, and also С3а and C5a-factors of complement. Standard treatment only partially correction immune and oxidant disturbances at systemic and local level that proves including of preparations with immunomodulating and membranoprotektor effects in complex treatment of such patients.