NEPHROSCINTIGRAPHY AND CYTOKINES IN THE DIAGNOSIS OF KIDNEY LESIONS IN VESICO-URETERAL REFLUX IN CHILDREN
There presented data of the examination of 76 children aged 2 to 16 years, with different grades of vesicoureteral reflux (VUR), one and bilateral lesions were detected in the ratio of 52.6% and 47.3%, respectively. The detection of a functioning renal tissue was performed with static nephroscintigraphy with 99mTc radiopharmaceutical Technemek 99mTc (99mTc labeled dimercaptosuccinic acid, (99m)Tc-DMSA), having activity of 80-600 megabecquerel (MBq), determined with dose calibrator. During static nephroscintigraphy kidney damage of varying severity were observed in all patients. 2-fold reduction of functioning parenchyma in the affected kidney was observed in patients beginning from VUR grade >3. The found evidences show that main factors of renal function disorders are not only the reflux grade, but also the type of nephrosclerosis, or their association, especially in bilateral VUR in children. The obtained data indicate that VUR in children causes changes in the structural and functional state of the kidneys. In this nephroscintigraphy allows to adequately assess functional status and renal parenchyma reserve in children with VUR.