PERSPECTIVE OF USING OF TUMOR MARKERS IN VETERINARY ONCOLOGY
Data on some tumor markers studied in mammary gland cancer in dogs and cats are given. The purpose of the article was to analyze the use of tumor markers in veterinary medicine. It can be assumed that the expression of PCNA, Ki67, IGF, VRCA1 and BRCA2 genes may be useful parameter for the diagnosis and monitoring of mammary gland cancer in dogs, and ERBB2 expression, VRCA1 and BRCA2 - in cats. But proto-oncogenes ERBB2 and SATB1 in dogs did not show increasing expression of in cancerous tumors and can not be used in veterinary oncology, as they are used in human one. Also does not fit for use as a tumor the marker protein P53 as it reflects the degree of DNA damage that may be caused by various factors and does not necessarily result to carcinogenesis. Estrogen receptor activity also can not be used, since in increase in tumor malignancy grows resistance to proliferative stimulation. In conclusion, it can be assumed that the study of the activity of genes responsible for DNA repair (CADD45, RAD17, RAD21, RPD21, RPA, SMC1A and TOPBP1), can be promising, as in human cancer have been identified mutations leading to DNA repair violation and the emergence of cancer already. It remains to reveal similar mutations in dog and cat genome.