THE INTENSIFICATION OF FREE RADICAL PEROXIDATION OF LOW DENSITY LIPOPROTEINS IN DIABETES MELLITUS TYPE 2
Aim: To study changes in the parameters of oxidative stress in patients with type 2 diabetes with disorders of carbohydrate metabolism before and after the sugar-lowering therapy. Subjects and methods: The study included 16 patients with newly diagnosed type 2 diabetes mellitus (DM-2) with the level of glycated hemoglobin HbA1c>9% who have not previously received sugar-lowering therapy. Before and after 3-month therapy aimed at normalizing glucose metabolism, examined the basic parameters of carbohydrate/lipid metabolism and oxidative stress, including the levels of HbA1c, malonyldialdehyde (MDA) and oxidized low-density lipoprotein (oxLDL) in blood plasma, and the activity of erythrocyte antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GSH-peroxidase) and catalase. Results: It was shown that the levels of LDL cholesterol and HDL cholesterol is not change in the process of effective sugar-lowering therapy in patients with type 2 diabetes, although there was a significant reduction of total cholesterol level on 13% and atherogenic coefficient on 26%. At the same time, oxLDL and MDA levels (on 25% and 47%, respectively) in the blood of patients with type 2 diabetes after sugar-lowering therapy decreased, and the activity of erythrocyte GSH-peroxidase significantly increased on 28%, whereas the activity of SOD and catalase were not significantly changed. Conclusions: These results indicate that under diabetes there is the intensification of free radical processes with subsequent accumulation of reactive carbonyl species (RCS), which iduced the atherogenic modification of LDL and facilitate manifestation of atherosclerotic lesions in vascular wall.