Role of Intraportal Infusion Therapy in Endovascular Treatment of Patients with Esophageal Variceal Bleeding as a Consequence of Portal Hypertension
Results of endovascular intervention in 113 liver cirrhosis patients complicated with portal hypertension and esophageal and gastric variceal bleeding are presented. In the I group 65 patients underwent transhepatic embolization of bleeding variceal veins and transfemoral embolisation of splenic artery and in the II group - 48 patients - catheterization of portal vein with infusion therapy for 4-8 days. Intraportal drug infusion in postembolisation period was accompanied with faster recovery of basic clinic and laboratory tests, particularly, changes in liver functional tests and it coincided with results of the I group patients. Prolonged catheterization of portal vein allowed the delivery of drugs directly to hepatocytes in certain concentration, controlling the portal pressure in postembolic period and allowed to perform occlusion of bleeding vessels, should recurrence of bleeding occur. Overall mortality came to 36.1%, i.e. 50.8%) in the I group and 18.7%) in the II. Thus, involvement of long-term endovascular intraportal interventions allows significantly improve outcome in gastroesophageal bleeding patients with liver cirrhosis.