The Accommodative and Hypotensive Effect of the Sympathomimetic Irifrin
The paper’s objective was to explore the accommodative and hypotensive effect of Irifrin 2.5% (10%) in myopes with different tones of the vegetative nervous system and in healthy volunteers on pharmacological models of tonic accommodation. Group 1 consisted of patients aged 7-22 (with myopia and a certain tone of VNS) who were prescribed instillations of sympathomimetic Irifrin 2.5% 2 times a day for 10-12 days. Group 2 consisted of people aged 7-23 with emmetropia or myopia, who received 10% Irifrin instilled in the right eye and Pilocarpine 1% in the left eye. A UBM test of pharmacological models of accommodation (pilocarpine 1%, irifrin 2.5%, irifrin 10%) was performed. Irifrin 2.5% was shown to increase distant visual acuity, weaken the myopic refraction, shift forward the farthest point of clear vision. This confirms the existence of distant accommodation controlled by the sympathetic VNS. If Pilocarpine 1% was instilled, a reduction of IOP was noted in addition to changes in the ultrasound biomicroscopic picture. Obviously, this reduction is associated with improved outflow through trabeculae. Irifrin 10% also contributed toIOP reduction. We can thus conclude that patients with progressing myopia who have habitual high IOP and who need some IOP reduction should be treated with hypotensive medications, concretely an adrenomimetic drug with a refractive effect. It is especially important for patients with vagotony.