Comparative indicators'' characteristic of oxidative stress in patients with psoriasis of varying severity and metabolic syndrome
Relevance. The lack of consensus on the causes and patterns of psoriasis makes the problem of studying the pathogenesis of this dermatosis relevant, which may allow developing new methods of pathogenetic therapy in the future. The results of the study of the lipid peroxidation state and antioxidant protection in psoriasis are often contradictory, which makes it relevant to study not only the investigation of the processes of free radical oxidation in psoriasis, but identifying the correlation of severity and comorbid pathology. Material and methods. The article presents research data of the total oxidizing capacity of blood serum, oxidized low density lipoprotein, total antioxidant activity of serum superoxide dismutase in patients with common form of psoriasis: 312 patients with diagnostic criteria of metabolic syndrome (Mets), 60 patients without manifestations of MS. The comparison group consisted of patients with limited psoriasis (n=60), control group - healthy individuals (n=50). The results of the study. The study reported a statistically significant relationship between the prevalence of psoriasis, presence of metabolic syndrome and the severity of oxidative impairment. Conclusions. These data confirm the importance of disorders of lipid peroxidation and antioxidant system in severe forms of psoriasis in patients with metabolic syndrome.