The role of organo-tissue barriers in the formation of a systemic infl ammatory reaction and neutralize toxins in pancreatic necrosis, the choice of rational tactics surgical treatment
Despite the intensive development of the diagnosis and surgical treatment of pancreatic necrosis (PN), mortality remains high, reaching 30-50% or more. This is due, on the one hand, with insuffi cient study of the mechanisms pancreatogenic toxemia, generalized infection, manifestations of the Systemic Infl ammatory Response (SIR) and the role of organ-tissue barriers in the neutralization of toxins (the liver, lungs, muscles and cellulate array), on the other hand, the ineffectiveness of drugs in their system application as a result of blocking organ microcirculation and limiting their availability. As a result, research has found evidence of the complexity of the SIR and the mechanisms of toxemia in the PN (enzymatic, metabolic and bacterial), which showed a high level of leukocytosis, the study of enzymes, especially when infected Mon, refl ecting the morphological and functional liver damage, as the primary detoxifi cation barrier pancreatogenic aggression. These humoral indicators can serve when they raise specifi c markers of the severity of toxemia and SIR. Application regional arterial drug therapy provider medicinal effect is in the region of defeat, can achieve better results in reducing mortality in Mon, compared with traditional methods of treatment.