CLINICAL AND BIOCHEMICAL EVALUATION OF THE EFFECTIVENESS OF THE APPLICATION OF LIPOSOMAL ANTIOXIDANT DRUGS WITH GESTOSIS IN PREGNANT COWS
Study of the system "lipid peroxidation - antioxidant protection" ("LP - AP") pregnant and dry cows in verification of diagnosis on the degree of severity of preeclampsia is of primary importance to monitoring treatment using liposomal antioxidant drugs. The aim of this work was to estimate the content of а-tocopherol, retinol, malondialdehyde (MDA) in the system of mother-placenta-fetus to determine the effectiveness of antioxidant therapy in preeclampsia cows and heifers in late pregnancy. To do this, pregnant cows with gestosis were divided into 3 main groups (on a scale of Wittlinger: in the 1st group of animals seized with eclampsia, mild (50), the 2nd - with preeclampsia middle degree (48), 3rd -with gestosis a severe degree (32). Indicators system "LP - AP" has sufficiently high diagnostic value in severe preeclampsia flow from globorotalia heifers and dry cows. So by reducing superoxide dismutase less of 1.55 conv. units it is possible to reveal 82.0 % subclinical ketosis animals. The purpose of antioxidant drugs to cows, outgoing into deadwood with clinically normal pregnancy, prevents the development of obstetric pathology in 92.8 % of the animals. Therefore, the plan to restore the functional activity of all organs and systems of the body in a clinically severe syndrome of preeclampsia and manifestation of subclinical ketosis, which is a multi-organ disease, should not only include antioxidant therapy, but other means acting on the normalization of the basic links of the pathological process.