QUANTUM-METABOLIC THERAPY IN THE CORRECTION OF DISORDERS OF HOMEOSTASIS IN SEVERE ACUTE PANCREATITIS AT EARLY STAGES
A clinical study of 47 patients with acute severe pancreatitis was conducted, whom were divided into 4 groups: group I (n = 19) - patients were on the background of traditional therapy with a duration of pathology less than 2 days; group II (n = 16) is similar to the first group, but the pathology duration was more than 2 days; Group III (n = 17) is similar to the first, but the general treatment included quantum metabolic therapy (laser therapy and Remaxol), group IV (n = 15) is similar to the third, but the duration of the disease was more than 2 days. For comparison with the norm, healthy individuals (n = 15) of both sexes and age from 25 to 60 years were examined. The functional status (aspartate aminotransferase activity, urea), the intensity of membrane lipid peroxidation processes (diene conjugates, thiobarbituric acid products), and the state of the hemostasis system (reaction time and coagulation index) in blood plasma were evaluated. It has been established that acute severe pancreatitis is accompanied by hepatic dysfunction syndrome, activation of lipid peroxidation processes, hemostatic disorders (hypercoagulation and hypofibrinolysis) in the early stages associated with the duration of the pathology. These changes were recorded above when the pathology was more than 2 days. Inclusion of laser therapy and Remaxol in the treatment leads to the restoration of the functional status of the liver, inhibition of lipid peroxidation and reduction of hemostatic disorders.