Inactivation of Bacteria with Photosensitizers Activated with a High Powered Nanosecond Pulsed Laser
This paper presents the results of the study that explored photoinactivation of bacteria with photosensitizers activated with a nanosecond pulsed laser. The power density of laser beam was 1-30 MW/cm2. The irreversible damage of living cells by shock waves arising at the nucleation and collapse of vapor bubbles in locally heated microregions of the medium is discussed. The local heating of the medium was realized due to heat generation during nonradiative relaxation of high electronic states of sensitizer molecules.