Pathophysiological and Clinical aspects of Nervous System affection in COVID 19
COVID-19 disease is characterized by respiratory ways and other organs and system affection. One of frequent clinical manifestation is neurological dysfunction. There is presented the most known up to day COVID-19 associated neurological disorders in this review. Among the most common neurological manifestations are myalgias, headaches, encephalopathy, dizziness, dysgeusia and anosmia. Other conditions such as meningitis, encephalitis, encephalomyelitis, hemorrhagic necrotizing encephapathy and Guillain Barré syndrome can be attributed to COVID-19 associated complications. The pathophysiological aspects underlying COVID-19 mediated neuroinvasion, which are based on the high affinity of binding of SARS-CoV2 to the ACE2 receptor, are presented.