FUNCTIONAL AND METABOLIC STATE OF LIVER AND KIDNEYS IN ENDOGENOUS INTOXICATION WITH LASER THERAPY
Endogenous intoxication syndrome caused by peritonitis is a pathogenetic factor, which determines development and progression of multiple organ failure. Conducted experimental studies on adult mongrel dogs, which simulated acute fecal peritonitis. A significant increase in the concentration of toxic products in the blood plasma, characterizes endotoxemia was found. Endogenous intoxication led to increase in titer of secondary products of free radical oxidation of lipids, phospholipase activation and antioxidant enzymes inhibition in liver and kidneys tissue. We studied the effect of low-intensity intravenous laser blood irradiation (unit Matrix, radiating head CL VLOK, and fibers KIVL-01) on the severity of endotoxemia and lipid metabolism in liver and kidneys. Application piloted methodology led to a decrease of expression of endogenous intoxication. Intravenous laser irradiation of blood reduces the intensity of lipid peroxidation, decrees phospholipase activity, and restores the activity of antioxidant enzymes in liver and kidney tissue.