INTERRELATIONSHIP AND PATHOPHYSIOLOGICAL INTERDEPENDENCE OF THE NEW CORONAVIRUS INFECTION (COVID-19) AND DIABETES MELLITUS
The paper aims at analyzing the recent publications on the impact of diabetes mellitus on the outcome of COVID-19, including patients with comorbid conditions. As the pandemic evolves, more and more knowledge is gradually emerging, but problems with understanding the relationship between DM and COVID-19 remain. In particular, the clinical significance of the potential direct effect of the virus on the function of pancreatic β-cells through the ACE-2 receptor, shown by in vitro and ex vivo studies, requires further inquiry. Most of the studies were conducted in patients with type 2 diabetes mellitus or in patients in whom the type of diabetes was not specified. However, recent data suggest that patients with type 1 diabetes mellitus are at higher risk for severe COVID-19 and increased mortality. The article also attempts to analyze studies on diabetes-like syndrome which occurs as a complication in some patients with COVID-19, and considers possible mechanisms for its development.