IMMUNOLOGICAL ASPECTS OF TISSUE REACTION IN EYE ANTERIOR PART WHEN USING SOFT CONTACT LENS FROM DIFFERENT MATERIALS
Cytokins dinamics (IL-1b, IL-4, IL-10, IL-12, TNF-a and INFg) in lecrimal fluid of patients with myopia when using soft contact lens from different materials was studied. Wearing of hydrogel lens for more than 2 years without any clinical complications was stated to cause the increase in concentration of IL-10, TNF-a and IFNg; decrease of IL-12 content. In the development of complications the level of all cytokins studied in lecrimal fluid sharply increases excepting IL-4, its content drops. When using silicone hydrogel lens cornea clinical changes were not registered but decrease in IL-12 level and increase of TNF-a and IFNg levels were less marked than in hydrogel lens. The data obtained may predict risk of negative processes and carry out their pathogenetic correction.