EVALUATION OF THE HISTOSTRUCTURE OF THE LIVER IN THE MUSES WHEN ADDING TO THE FEED OF MILDRONATE
Meldonium has a wide range of biochemical effects on the body. The drug has an antihypoxic effect, promotes vasodilation, utilization of products of incomplete glucose metabolism. The paper deals with the effect of mildronate on the histological structure of the liver in laboratory animals. The study was performed on females of white mongrel mice who were in the same feeding and keeping conditions. Animals of the experimental group in addition to the diet added Mildronate at the rate of 0.0078 mg, per gram of live weight per day with water, for 3 months courses of 30 days, with a break of 7 days. Mice of the control group did not receive the drug. It was established that in the control group, the architectonics of the liver cells was violated. Hepatocytes and their nuclei are enlarged and swollen, the cytoplasm of the cells is cloudy and contains vacuoles formed from dissolved fat, the areas of sinusoidal capillary are enlarged. Histological examination of mice in the experimental group treated with mildronate showed an improvement in the microcirculation in the liver, the restoration of the structure of the liver beams.