EFFECTS OF FIXED COMBINATION OF LOSARTAN AND HYDROCHLOROTHIAZIDE ON ENDOTHELIAL DYSFUNCTION AT MODELLING HYPERHOMOCYSTEINE-INDUCED DEFICIENCY OF NITRIC OXIDE
The study endothelial and cardioprotective effects of losartan, hydrochlorothiazide and fixed combination of losartan and hydrochlorothiazide in modeling hyperhomocysteine-induced deficiency of nitric oxide. The results obtained allowed to establish expressed endothelial dysfunction and prevention adrenoreactivity increase and decrease of myocardial reserve in the experiment with the use of fixed combination of losartan 8 mg/kg and hydrochlorothiazide 2 mg/kg.