THE IMPACT OF POLYMORPHISMS WITHIN GENES ENCODING TOLL-LIKE RECEPTORS ON MYOCARDIAL INFARCTION RISK
In recent years, a number of research groups carried out investigations on the role of polymorphisms within genes encoding innate immune receptors in cardiovascular diseases. However, there are contradictory results regarding the role of polymorphisms within genes encoding Toll-like receptors (TLRs) in myocardial infarction (MI). Subject of the investigation: Eight polymorphisms within four genes encoding Toll-like receptors: TLR1 (rs5743551 and rs5743611), TLR2 (rs3804099 and rs5743708), TLR4 (rs4986790 and rs4986791), TLR6 (rs3775073 and rs5743810). Aim - to determine the clinical significance of polymorphisms within genes encoding Toll like receptors in patients with myocardial infarction. Methods. We recruited 291 patients with coronary artery disease (CAD), and 223 of them had MI. We investigated 8 polymorphisms within 4 genes: TLR1 (rs5743551 and rs5743611), TLR2 (rs3804099 and rs5743708), TLR4 (rs4986790 and rs4986791), and TLR6 (rs3775073 and rs5743810). Results. We found that C/C genotype of rs3804099 polymorphism within TLR2 gene is significantly associated with reduced myocardial infarction (MI) risk amongst males. However, T/C genotype of rs3775073 polymorphism within TLR6 gene is significantly associated with increased MI risk amongst subjects under 55 years of age. There were no statistically significant associations for rs5743551 and rs5743611 polymorphisms within TLR1 gene, rs5743708 polymorphism within TLR2 gene, rs4986790 and rs4986791 polymorphisms within TLR4 gene and rs5743810 polymorphism within TLR6 gene. Conclusions. We determined statistically significant associations with MI risk for C/C genotype of rs3804099 polymorphism within TLR2 gene and for T/C genotype of rs3775073 polymorphism within TLR6 gene.