Polymorphism 416 Т>С of gene CYP2C9 and sensitivity to clopidogrel
Relationship between clopidogrel resistance and gene polymorphism of cytochrom Р450 was studied. Clopidogrel resistance was revealed by light agregatometry in 12 out of 60 (20%) patients with ischemic heart disease, hyperlipidemia and ulcerous disease. Patients were treated by clopidogrel in dose 75 mg per day for 2 months. Platelet aggregation was studied before and after treatment. Genetic isoenzymes variants of cytochrom P450 system - CYP2C9 (416 T>C and 1061 T>A) and CYP2C19 (681 G>A), platelets receptors involved in aggregation - P2Y12 (52G>T) and glycoprotein receptors IIb/IIIa (1565 C>T) were studied. A correlation between gene CYP2C9 polymorfism and clopidogrel resistance was found.