Modern technologies in the combination treatment of preinvasive cervical diseases
Objective. To evaluate the efficiency of different therapies for cervical intraepithelial neoplasia (CIN) I-III. Subjects and methods. One hundred and thirteen patients with severe dysplasia were examined and treated; four groups were formed in accordance with performed treatment. Results. The most active epithelialization was noted after photodynamic therapy (PDT). Completed epithelialization after PDT alone was seen more frequently than after other therapy options. No cervical deformation was detected after PDT. Addition of PDT-induced excision caused an increase in the number of standard cytogram readings, followed by the most pronounced and long-term antiviral effect, and reduced the rate of the vaginal environmental alkalinization. Conclusion. PDT is a highly effective treatment option for cervical dysplasia, can avoid scarring after excision, provides an antiviral effect, and promotes vaginal microbiome normalization. This allows one to recommend that PDT should be incorporated into a complex of treatment for reproductive-aged women in particular.