CHYMOTRYPSIN C (CTRC) GENE MUTATIONS IN THE PATHOGENESIS OF CHRONIC PANCREATITIS
Identification of chymotrypsinogen C (CRTC) gene mutations has extended our understanding of the pathophysiology of chronic pancreatitis (CP). The review considers the mechanisms responsible for the development of CP in the presence of mutations of this gene. Mutations of these or those genes possibly with other so far unidentified genetic, exogenous, and environmental co-factors are more likely to be modifiers of the disease in most cases of CP.