Reference values of abdominal and cerebral oxygenation in term infants: a pilot study
The aim of this prospective observational study was assessment of regional oxygenation, cerebral fractional tissue oxygen extraction and viscerogenic and cerebral oxygenation ratio in stable full- term newborns in the dynamics of the early neonatal period.During the follow-up period, 82 full-term newborns were monitored. For further processing, the data of 27 infants were available. Regional oxygenation was measured with the cerebral/somatic oximeter Invos 5100C (Covidien, Medtronic, USA). Dynamical changes cerebral oxygenation were characterized by a tendency to decrease in values, which persisted for the first four days of life, after which the growth was equally smooth.In turn, abdominal oxygenation was determined by a sharp drop in values on the second day of life, which was subsequently replaced by their growth towards the end of the early neonatal period. The mean daily fluctuation of cerebral and abdominal oxygenation indices was 7 [4; 10]% and 10 [5; 16]% respectively (p<0.001).With the first day of life, cerebral fractional tissue oxygen extraction tended to increase, which from the fourth day gave way to a decrease, and by the end of the observational period it was marked by a sharp increase. Viscerogenic and cerebral oxygenation ratio was characterized by a rather sharp drop in the second day of life. The recorded values of 0.87 [0.70; 0.95] were minimal for the entire observation period.Monitoring regional oxygenation using NIRS is a fairly sensitive, non-invasive method, to detect changing in regional perfusion. The data obtained can be used both for interpreting results from NIRS oximeters in group risk patients, for clinical guidance in developing a therapeutic strategy as well