Comparative efficacy of a fixed combination of mometasone with azelastine and complex treatment of allergic rhinitis
According to modern views, allergic rhinitis (AR) is a chronic inflammatory disease which is associated with Ig E dependent reaction on the surface of the nasal mucosa, characterized by symptoms such as itchy nose, sneezing, nasal congestion and nasal discharge. The main principleof pathogenetic treatment is the long-term use of anti-inflammatory therapy aimed at controlling the symptoms of the disease. The drugs of the first line are inhibitors of histamine receptor H1 and topical corticosteroids.Aim of the study. To study the effectiveness of the combined administration of Glenspray with azelastine in the treatment of allergic rhinitis.Materials and methods. Our study included 60 patients with AR, divided into two groups. Patients of the main group were assigned mometasone furoate 50 mg and azelastine hydrochloride 140 mg in one dose, control group - mometasone furoate 50 mg and levocetirizine hydrochloride in tablets 5 mg. Efficiency of the treatment was assessed by the degree and time of regression of the main clinical manifestations of AR. We also conducted a scoring assessment of patients’ compliance.Results of the study. The results of the control examination on the third day of the treatment showed a positive dynamics of the symptoms in patients of both groups, but significantly more pronounced in the main group. Starting from the seventh day, the effectiveness in both groups was almost equal. The high efficiency of the combined topical drug was correlated with good compliance.Conclusions. Results of our research allow us to make a conclusion about high efficiency of administration of a complex topical drug as a method of pathogenetic treatment of patients with AR.