Genetic polymorphism: theory and practice
The lecture discusses the genetic polymorphism and its role in medical practice. As an illustration of the concept of genetic polymorphism, the representation of the major histocompatibility complex and the role of its individual genes in predisposition to the development of human pathology is used. Applied aspects of genetic polymorphism are demonstrated on the example of blood groups acording to ABO system, features of xenobiotic metabolism (eg, warfarin and isoniazid) in different categories of patients, the deficiency of glucose-6-phosphate dehydrogenase deficit. Genetic polymorphism is considered as one of the most important components of the development of personalized medicine.