THERAPEUTIC APPROACHES TO THE TREATMENT OF MALASSESIA-ASSOCIATED DERMATOSES
The article analyzes the data on the effectiveness of the main methods of treatment of malassezia-associated dermatoses with antimycotic drugs. Purpose of the study: based on a review of recent scientific publications, to determine the role of Malassezia fungi in the pathogenesis of chronic dermatoses (psoriasis, seborrheic dermatitis) and the effectiveness of systemic and external antimycotics in complex therapy. Materials and methods. The search for scientific articles was carried out in the databases "PubMed" and "eLIBRARY" using the keywords "malassezia" and "treatment". Search depth - 10 years. The final analysis included 16 research articles, where the results of their own research were presented. Results. Malassesia fungi have been found to play an important role in the pathogenesis of psoriasis by inducing increased production of molecules involved in cell migration and hyperproliferation, contributing to the exacerbation of dermatosis. With seborrheic dermatitis, yeast penetrates into the stratum corneum, releasing lipases, which leads to the formation of free fatty acids and contributes to the development of the inflammatory process. The use of external antimycotics contributes to a more rapid regression of rashes.