QUALITATIVE AND QUANTITATIVE DETERMINATION OF FLAVONOIDS IN THE DEVELOPED SOFT ANTIARTHRITIS AND ANTIARTHRITIS DOSAGE FORMS
Arthritis and arthrosis are serious diseases among humans and animals. In some cases, there are no apparent reasons - idiopathic or primary. There is also a secondary - developed as a result of some pathological process. Recently, the disease began to progress. From the existing Arsenal of drugs for the complex treatment of this disease, a special niche is occupied by drugs based on natural compounds [1]. Medicines from plant objects cheaper synthetic analogues, well combined with other drugs. They can be safely used in combination with agents for the treatment of diseases complicated by concomitant diseases, have low toxicity, no side effects, even with long-term use, a plurality of pharmacological properties, due to which herbal preparations affect several systems of the body. One of the alternatives to injection and oral administration may be local therapy in both humans and animals. Local influence of drugs at the site of pathology accelerates the processes of recovery, recovery and elimination of symptoms [1]. To this end, we have developed soft dosage forms for topical use, containing a complex phytocomplex of 13 plant objects, where flavonoids act as the main complex of biologically active substances. Materials and methods: Chromogenic reactions were used for qualitative analysis and spectrophotometry for quantitative analysis. The complex extract necessary for the introduction and formation of ointments was obtained from 13 plant objects: chamomile, calendula, cumin, pine, yarrow, mint, rose hips, fennel, licorice, wormwood, thyme, St. John's wort, celandine. Results. The results of qualitative and quantitative analysis confirmed the content of flavonoids. Conclusion: Color reactions fully confirmed the fla-vonoid structure of biologically active substances. The quantitative content of flavonoids in terms of routine in different ointments is 0, 051 - 0.060.