ISCHEMIC STROKE AND HEART RATE VARIABILITY
The review summarizes information on the reduction of heart rate variability (HRV) and circadian index (CI) of heart rate in the acute period of ischemic stroke. Progression of these two rates is connected with acute cerebral damages. It is testified that the reduction of both HRV and CI (which demonstrates the decrease in adaptive capability) raises the risk of adverse heart events over a period of stroke. The decrement of HRV is usually associated with the decrease of central, humoral and autonomic regulations of heart. This review describes significant suppression of the autonomic regulation of heart (including the decrease of HV and CI rates), stipulated by damages of some brain structures. The question on how the reduction of HVR is connected with the severe neurologic impairment, the center of insult, the indices of hemodynamics, age, metabolic damages, the serum calcium level is being discussed. It is shown that the HVR damages remain unchanged after the acute period of the decease, secondary to the evolving reduction of parasympathetic, sympathetic and humoral-metabolic influences on the heart rhythm.