The characterof the inflammatory changes in the saliva of patients with Helicobacter pylori infection
Introduction. Helicobacter pylori (H.pylori) infection is quite common among the population of the world's population, and therefore of particular interest to researchers of all countries. It was revealed the presence not only the microorganism in the organs of the gastrointestinal tract, but also in the periodontal pocket. Аim: determine the nature of the inflammatory changes of saliva in the presence of H.pylori infection in the mouth and evaluate the effectiveness of comprehensive eradication therapy with the immunomodulator imudon. Results. Presence of inflammatory changes in the saliva of the patients in whom H.pylori was determined by PCR in the oral cavity. The inclusion of topical immunomodulator imudon in the complex therapy of H.pylori-associated diseases reduces the inflammatory potential by reducing the concentration of TNFα, IL-6 in saliva and to increase protective properties of saliva as a result of increasing the level of mucin, but also significantly reduces the frequency of relapses within one year after the therapy. Conclusion. Practically important is the identification of the genetic material of H.pylori in the periodontal pocket, as well as increased anti-inflammatory potential of saliva by adding immunomodulator Imudon in eradication therapy to reduce the frequency of relapse of H.pylori infection in the gastrointestinal tract.