DYNAMICS OF INTRA-ABDOMINAL PRESSURE AND PROCALCITONIN LEVEL IN THE BLOOD IN INTESTINAL OBSTRUCTION: EXPERIMENT
This article presents the results of an experimental study of the dynamics of intra-abdominal pressure and Procalcitonin with intestinal obstruction. Purpose of the research: to study the dynamics of Procalcitonin and intra-abdominal pressure during intestinal obstruction in the experiment. Methods. The study was conducted on 131 white mongrel rats. They were divided into two groups: 1st group - 91 rats with acute small intestinal obstruction, 2nd - comparison group (Sham-surgery) - 40 rats. In both groups of animals are equally divided into 4 groups depending on the time of observation (1, 3, 5 and 7 days). Results: The study indicated a statistically significant increase of Procalcitonin by more than 5 times (p < 0.05) since the 1st day with the reaching of the maximum values to 5th day. As well as a significant increase in intra-abdominal pressure on 3, 7 experiment day (p <0,007) and compared with the comparison group. Conclusion: The obtained experimental data indicate the need to monitor indicators of intra-abdominal pressure in acute intestinal obstruction as an early diagnosis and prompt treatment. A study of the dynamics of Procalcitonin in acute intestinal obstruction showed that this marker can effectively record the initial stages of translocation of microorganisms. It also can serve as a reliable early marker of bacterial migration and translocation in the initial period of acute small intestinal obstruction early septic complications of this pathology.