BIOBANKING OF PATIENT-DERIVED XENOGRAFTS AS A BASIS FOR TRANSLATION RESEARCH IN ONCOLOGY
High rates of cancer incidence and mortality make the development of new therapeutic agents an important task of modern medicine. Realization of the potential of scientific discoveries in clinical practice requires access to biological samples and their accompanying data for a thorough assessment of a potential therapeutic target, its relationship with a specific disease and the degree of the antitumor response when exposed to the studied agent. The development of biomedical technologies resulted in the creation of biobanks storing collections of preparations, including both tissue samples from patients, such as biopsy and surgical fragments of tumor and normal tissues, serial blood samples, paraffin blocks, and biological samples derived from them, such as cell lines, organelles, and xenografts. This article provides an overview of biobanks with the most extensive annotated collections of tumor samples, including patient-derived xenografts, and describes an algorithm for searching for the required tumor model using the global PDX Finder catalog; we discuss the development of directions related to the creation and storage of collections of biological products for their use in translational research in oncology.