FUNCTIONAL BLOCKADE OF CELLS SYNDROME IN ACUTE PANCREATITIS
Parameters of microcirculation in 16 patients with severe forms of acute pancreatitis were defined by enemometry. In this disease severe injuries were revealed. They were manifested by a significant increase in the maximum pressure drop (MPD), increases in the hyperhydration index (IH) inflow-outflow index (IIO) demonstrating significant violations of the vascular component of microcirculation (MPD, IH, IIO). This was accompanied by profound alterations of the cellular component of the microcirculatory environment: reduction of the integral microcirculation pressure (IMCP) and tissue pressure (TP). Changes in the cellular component of the microcirculation were accompanied by reduction of IMCD and TP coefficients. These findings reflected the microcirculatory code of severe acute pancreatitis: hyperhydration tissue, reducing the integral of the microcirculation and tissue pressure. The method of edemometry identified another syndrome - functional blockage of the cells of the microcirculatory environment. When injected into the vein of 1.0-1.5 liters of glucose and electrolytes in patients with severe clinical forms of acute cholecystitis, the cells of the microcirculatory environment actively respond to the infusion, which was accompanied by a decrease in MPD, increasing IMCP and TP. After the introduction into the vein of the same amount of glucose and electrolytes in patients with severe forms of acute pancreatitis all the original parameters of microcirculation remained unchanged. Such inertness of the microcirculatory system is due to the functional blockade of cell of this environment in this disease.