Peculiarities of exchange of bone tissue with chronic intoxication elements contained in the copper-zinc sulphide ores
Chronic toxicity of white adult rats administered daily powder suspension of copper-zinc sulphide ore in the three months leading to the accumulation in the bones of the peripheral skeleton of some heavy metals: lead, mercury, cadmium, iron, manganese, strontium, copper, and zinc. Observed prevalence of bone resorption and bone collagen catabolism. This is evidenced by increasing plasma levels of C-terminal telopeptide of collagen type I and free hydroxyproline in the epiphysis of long bones while maintaining the activity of bone alkaline phosphatase and protein-hydroxyproline. Intensification of catabolic processes associated with activation in the bone tissue and the inhibition of free radical antioxidant components (total antioxidant activity of the tissue, the activity of superoxide dismutase, glutathione peroxidase and catalase).