Clinical Effectiveness of Minimally Invasive Diagnostics of Cellular Rejection after Kidney Transplantation
Purpose. To demonstrate clinical effectiveness of use of the developed algorithm for diagnostics of cell rejection of renal allograft in the long term after transplantation. Materials and methods. We conducted a prospective interventional comparative study, which included 10 patients. The experimental study group included 5 patients with rejection, which was diagnosed with the developed algorithm. The control group consisted of 5 patients with non- immune transplant dysfunction. In the experimental study group, specic rejection therapy was initiated, according to the results of the proposed test. All the participants underwent a kidney transplant biopsy. Results and discussion. The use of specic therapy based on the results of the proposed algorithm led to decrease of serum creatinine (140 127 111 mol/l) and increase of GRF (43.5 46.5 58.6 ml / min). The comparison of the results of the proposed method with the results of the histological study demonstrated good diagnostic characteristics. Sensitivity and specicity were 100.0 (95 CI 45.97100.0) for both characteristics. Conclusions. The use of specic therapy for treatment of late cellular rejection based on the results of the proposed algorithm is effective. The proposed algorithm has good diagnostic characteristics in comparison with histological examination