Neurological Clinical Manifestations, Associated with COVID-19
The article represents a review of literature on neurological manifestations of the novel coronavirus disease COVID-19. Neurological complications of COVID-19 may include different signs and have different severity. Cases of cerebral complications of COVID-19 included ischemic stroke, acute hemorrhagic necrotizing encephalopathy, meningitis and encephalitis. Acute peripheral nerve system manifestations comprised anosmia and ageusia, Guillain - Barre syndrome, Miller Fisher syndrome, cranial polyneuritis. COVID-19 can cause musculo-skeletal complications, such as myalgia, complicated course of comorbid neuromuscular disease. Possible mechanisms for nerve system involvement are discussed, which include hypoxia, impaired systemic circulation, endothelial dysfunction with hypercoagulation and thromboses, direct viral invasion and immune-mediated reactions.