MMUNE STATE FEATURES OF WORKERS ENGAGED INTO PHTHALIC ANHYDRIDE PRODUCTION
Examination of workers engaged into phthalic anhydride production revealed reliable changes of immune regulation parameters (if compared to normal and reference group values): decreased phagocytic activity according to "relative phagocytosis" criterion, deficit of serum IgG, hyperproduction of specific IgE antibodies to phthalic anhydride (by its metabolite - phthalic acid). Findings are reliable (if compared to the reference group) decrease of CD95 T-cell receptors expression, disordered launch and regulation of apoptosis via changed expression of TNFRI (hyperproduction) (p<0,05). Findings also included increase intracellular regulatory proteins bcl-2 and Bax production, deficiency of transcription factor p53, reliably changed in comparison with the reference group (p<0,05). The results obtained demonstrate key features of immune regulation in workers engaged into phthalic anhydride production - activated processes of natural cellular death of immunocytes and specific sensibilization to phthalic anhydride.