Significance of vitamin D deficiency correction in the combination treatment of metabolic disorders in patients with polycystic ovary syndrome
Objective. To assess 25(OH)D deficiency correction in the combination treatment of metabolic disorders in patients with polycystic ovary syndrome (PCOS). Subject and methods. A total of 44 patients aged 31.32±5.05 years with PCOS were examined and randomized into 2 groups: 1) patients who received combined oral contraceptives (COC), biguanides, and colecalciferol; 2) those who used COC and biguanides. A comparison group consisted of 22 healthy women matched for gender and age. PCOS was verified in accordance with the 2012 ESHRE/ASRM diagnostic criteria. 25(OH) vitamin D (ng/ml) was measured by enzyme immunoassay. Fasting glucose and insulin and HOMA insulin resistance index were investigated. The Beck Depression Inventory was applied. The data were processed using the R-system. Results. The patients with PCOS were found to have obvious 25(OH)D deficiency associated with hyperandrogenism, hyperglycemia, hyperinsulinemia, insulin resistance, and depression. The administration of colecalciferol led to better carbohydrate metabolism, alleviated the manifestations of PCOS, and reduced waist circumference, waist-hip ratio, and depression. Conclusion. Correction of 25(OH)D deficiency contributes to the improvement of metabolic and psychological parameters and fertility.