CHARACTERISTICS OF HEART RATE CHRONOSTRUCTURE IN PATIENTS OPERATED ON FOR SOME DISEASES OF EAR, NOSE AND THROAT WITH THE USE OF DIFFERENT TYPES OF ANALGETIC THERAPY
Pain syndrome has a considerable effect on homeostasis of the body at the expense of interrelations between some neuron structures and the autonomic nervous system which controls a number of functions having a fluctuating character. In this work we studied heart rate chronostructure in patients operated on for some diseases of ear, nose and throat with the use of different types of analgesic therapy: metamizole sodium, ketorolac, trimeperidine and anaesthetic support (ketamine). It was found that in case of metamizole sodium and ketorolac therapy a tendency to night bradycardia is observed whereupon in the metamizole sodium group the most profound disorders of HR circadian profile were revealed. The use of trimeperidine and anaesthetic support was not accompanied by such considerable disturbances of cardiac rhythm chronostructure. Meanwhile in the trimeperidine group an increase in both day and night HR was observed. It is concluded that otorhinolaryngologic surgery with the use of various types of analgesia may induce different changes of cardiorhythm chronostructure in their direction and character. Thus when treating an acute postsurgical pain syndrome it is necessary to take into consideration characteristics of chronopharmacodynamics of the medicines used for this purpose.