THE ASSESSMENT OF LIPIDS PEROXIDATION VALUES, ANTIOXIDANT SYSTEM OF THE BLOOD AND ENDOTHELIAL CONDITION IN PATIENTS IN THE PRESENCE OF INTRAUTERINE GROWTH RETARDATION
The purpose of the present study was to examine the features of the processes of lipid peroxidation, as well as the state of the endothelium in patients in the presence of intrauterine growth retardation (IUGR) and in physiological pregnancy. The first group consisted of 40 female patients with the diagnosed IUGR, in the second one there were 43 female patients with normal pregnancy. Venous blood samples in the 3rd trimester were collected. To assess lipid peroxidation processes the following parameters were studied: S (total chemiluminescence light sum, mV/s), Imax (the maximum intensity during the experiment, mV/s). The activity of antioxidant systems was evaluated according to tg 2 index (tg of the angle of maximum inclination of the curve to the time axis) as well as Z and K coefficients. As a marker of endothelial dysfunction the quantification of circulating endothelial cells (CEC) by the method of Hladovec J. et al. was chosen. It was determined that the pregnancies complicated by IUGR significantly more often were accompanied by the suffered acute respiratory diseases during the 1st trimester (55,8% and 32,5%, respectively), extragenital pathology (51,2% and 27,5%, respectively), primarily due to chronic pyelonephritis (16,3% and 7%, respectively). IUGR was combined with a significant increase in the activity of lipid peroxidation processes and antioxidant activity of the blood of pregnant women (the S index was higher by 7,7%, Imax was higher by 6,7%, and tg 2 - by 6,7% in 1st group (p<0,05)), and endothelial dysfunction (CEC number =21 (18 ; 25) in the main group and 12 (9; 15) in the control one, p<0,001). Systemic analysis of correlations showed that on the formation of IUGR due to atypical interconnections the foundation of a new functional system takes place the activity of which is aimed at the ensurance of the fetal growth and develpoment.