The phylogenetic and functional difference of biological reactions of hydro-dynamic and arterial pressure. The local biological reaction of inflammation and systemic increase of arterial pressure
In phylogenesis, regulation of metabolism formed autocrine separately in paracrin regulated cells cenosises and on the level of organism. Under essential (metabolic) arterial hypertension organs-targets are involved into pathological process for the second time; realization of biological functions of homeostasis, trophology, endoecology and adaptation are disturbed for the second time too. Every organ-target regulates in vivo function of local hydro-dynamic systems: kidneys - pool of primary urine; brain - pool of cerebrospinal fluid; lungs - blood of pulmonary circulation. The arterial pressure is increased not by kidneys but by vasomotor center on the basis of afferent information from chemoreceptors about disorder of metabolism and micro-circulation n and hence initiates efferent stimulation of heart, increase of arterial pressure in proximal and hydro-dynamic pressure in distal section of arterial flow. The increasing of arterial pressure in afferent arteriole of glomeruli can increase filtration more than proximal tubules can reabsorb primary urine. The angiotensin is called to decrease arterial pressure over basal membrane because together with aldosterone they preserve parameters of intercellular medium in vivo. Under metabolic arterial pressure, the purpose of vasomotor center is to ameliorate realization of biological function of endoecology; to decrease amount of biological “garbage” of small sizes and “uremic toxins” in intercellular medium; to decrease afferent, parasympathetic signalization from chemoreceptors; to decrease sympathetic stimulation of heart. The formation of three stages of relative “biological perfection” in phylogenesis and non-eliminated “regulatory inconsistencies” on autocrine level, both in paracrin regulated cells cenosises and on level of organism, constitute pathogenic foundation, united algorithm of pathogenesis of all metabolic pandemic - “civilization diseases”, including metabolic syndrome, metabolic arterial pressure, atherosclerosis, insulin resistance and obesity. The aphysiologic impacts of environment are most often the etiological factor of metabolic epidemic.