DISORDERS OF THE FUNCTIONAL STATE OF THE LIVER IN THE EARLY POSTSURGERY PERIOD AFTER CHOLESTYSTECTOMY
The aim of the study was to research the functional state of the liver in the preoperative and early postoperative period after cholecystectomy in patients with acute cholecystitis complicated by obstruction of the vesicular duct with empyema or local peritonitis. 94 clinical cases of patients with acute calculous cholecystitis who underwent laparoscopic cholecystectomy were analyzed. All patients were examined with biochemical blood and urine tests, toxic substances test, markers of oxidative stress and antioxidant system also were determined.results: in the groups of patients with complicated inflammatory process in the gallbladder (empyema, peritonitis) the markers of the functional activity of the liver compared with those in non-occlusive cholecystitis were changed to a greater extent during the early postoperative period. A similar picture was revealed in the study of endotoxicosis in patients with acute destructive calculous cholecystitis. With the development of acute destructive calculous cholecystitis in pa-tients, the intensity of free radical processes of lipid peroxidation increased.Conclusion: in patients with acute destructive cholecystitis who underwent laparoscopic cholecys-tectomy, before the operation and in the early postoperative period (especially in the first two days) there is a violation of the detoxification and synthetic activity of the liver. More pronounced data of the disorder with occlusive destructive cholecystitis complicated by acute empyema, as well as destructive cholecystitis, complicated by the peritonitis, which aggravates the course of the early postoperative period.