Hyperbilirubinamia in the development of encephalopathy in liver cirrhosis
The importance of hyperbilirubinemia in the development of hepatic encephalopathy (HE) in patients with liver cirrhosis (LC) was studied. 27 patients of the viral etiology LC were examined (18 - chronic hepatitis B, 9 - chronic hepatitis C). The content of bilirubin in blood serum in patients with LC varies depending on the severity of the pathological process. In univariate analysis, the following measures were significantly (p≤0.05) associated with poor prognosis: HE, hyperbilirubinemia, hypercreatinemia, hypoalbuminemia, and reduced prothrombin time. Our studies confirm that bilirubin levels increase with irreversible impaired liver function. Increasing bilirubin over time helps reduce the likelihood of survival. On the base, the bilirubin content of patients with LC can be divided with a low or high risk of death from liver failure with the development of HE.