PHYSIOLOGICAL FACTORS OF THE FORMATION OF PROOXIDANT-ANTIOXIDANT HOMEOSTASIS IN GILTS
. It is presented the results of studies on the influence of physiological factors in gilts on the features of the formation of prooxidant-antioxidant homeostasis in connection with a change in the hormonal background. It was determined the fact that with a change in the physiological state in gilts to ensure the fertilization process with the onset of estrus in blood the peroxidation processes are intensified - increasing the concentration of diene conjugates (p <0.05) and TBA-active complexes, the functional activity of antioxidant enzymes - superoxide dismutase and decreasing in concentration of catalase (p <0.05), as well as an increase in the content of vitamin A and vitamin E, relative to the luteal phase. Such changes are obviously due to an increase in the amount of progesterone, estradiol-17β (p <0.05), thyroxine (p <0.05) and triiodothyronine. During the period of implantation and placentation of embryos, concentrations of thyroid and steroid hormones steadily increase. This is accompanied by a change in the state of prooxidant-antioxidant homeostasis in the direction of intensifying the peroxidation processes - increasing the number of diene conjugates (p <0.05 ... 0.01) and TBA-active complexes (p <0.05), against the background of an increase in the content of vitamin A and vitamin E (p <0.05), with a decrease in the concentration of ascorbic acid (p <0.05). In gilts, during the period of completion of neonatal development of piglets, it is increased the concentration of progesterone (p <0.05 ... 0.01) and estradiol-17β (p <0.01 ... 0.001) in the blood serum. During this period, there is an increase in the number of primary (p <0.01) and secondary (p <0.05) lipid oxidation products, which is accompanied by a decrease in the content of reduced glutathione (p <0.05 ... 0.01), ascorbic (p < 0.01 ... 0.001) and dehydroascorbic acids (p <0.05). In the postpartum period, a high level of peroxidation processes and the use of low molecular weight antioxidants is maintained. The formation of prooxidant-antioxidant homeostasis in blood of gilts depends on the influence of physiological factors that determine the reproductive cycle - preparation and maintenance of the fertilization, implantation and placentation of embryos, the intensive growth of piglets and their birth.