Role of genes involved in immune response and inflammation and the pathogenesis of ovarian cancer
Ovarian cancer (OC) is one of the leading factor in mortality among the cancers of the female reproductive system. One of the important risk factors for ovarian cancer acts is a genetic predisposition. Recently in the study of the malignant neoplasms pathogenesis of ovary special attention was paid to the role of the immune system. This review presents the analysis of domestic and foreign literature devoted to the role of proinflammatory cytokines that mobilize inflammatory response, inflammatory cytokines limiting the development of inflammation, the transcription factors and other participants of the immune response in the ovarian carcinogenesis.