Morphometry of endotheliocyte in the early diagnosis of fetoplacental system disorders
Objective: to improve the early diagnosis of fetoplacental system disorders based on computer morphometry of endotheliocytes in the first trimester of pregnancy. Material and methods. An observational prospective study of the endothelial state in a pregnant woman and fetus was performed using the "case - control"method. We examined 180 women in the first trimester whose pregnancy was terminated: 90 patients were diagnosed with a failed miscarriage, 90 women had a medical abortion at will. All pregnant women were diagnosed with endothelial dysfunction and morphometry of circulating endothelial cells was performed and morphometric examination of fetal chorionic vessels was performed in all the subjects. The results were subjected to statistical analysis. Results. Comparative analysis of markers of endothelial damage in pregnant women and fetuses showed a strong correlation between most of the studied indicators. Conclusion. Morphometric study of desquamated peripheral blood endotheliocytes in a pregnant woman can be a diagnostic marker of early vascular disorders in the fetoplacental system and represents a promising direction for the prevention of obstetric and perinatal pathology.