Synthesis, Structure and Biological Activity of Coordination Compounds of Copper, Nickel, Cobalt and Iron with Ethyl <i>N</i>'-(2-Hydroxybenzylidene)-<i>N</i>-prop-2-en1-ylcarbamohydrazonothioate
N -(Prop-2-en-1-yl)hydrazonocarbothioamide reacts with iodoethane in methanol with further addition of 2-hydroxybenzaldehyde to form hydroiodide of carbamohydrazonothioate (HL·HI). The coordination compounds were obtained by interaction of HL or HL·HI with copper, nickel, cobalt and iron salts CuLХ· n H<sub>2</sub>O [X = Cl<sup>-</sup>, Br<sup>-</sup>, NO<sub>3</sub><sup>-</sup>; n = 0-1], Ni(L)<sub>2</sub>·HI·CH<sub>3</sub>OH, Сo(L)<sub>2</sub>X [X = I<sup>-</sup>, NO<sub>3</sub><sup>-</sup>] and Fe(L)<sub>2</sub>NO<sub>3</sub>. The structures of three complexes were established by single crystal X-ray analysis. The synthesized complexes exhibit selective antimicrobial and antifungal activity against a series of standard microorganisms and fungi in the concentration range of 30-500 μg/mL. In addition, nickel and iron complexes selectively inhibit the growth and proliferation of cancer cells and do not adversely affect normal cells.