Clinical and laboratory correlation in patients with consequences of traumatic brain injury
The aim of this study was to establish main peculiarities of apoptosis of peripheral blood leukocytes in patients with traumatic brain injury consequences of varying severity under conditions of disease progressionMethods. In 220 patients with the effects of light (71), moderate (59) and hard (90) TBI and the catamnesis of trauma in the age from 1 to 30 years percentage of peripheral blood leukocytes in stage of apoptosis (ANV+) and necrotic (PI+) and the level of reactive oxygen species (ROS+) was explored by flow cytofluorometry method. The control group consisted of 30 people representative by age and sex. Neurological status was assessed by Neurolog- ical Outcome Scale for Traumatic Brain Injury (NOS-TBI), cognitive status - Montreal scale for cognitive deficit (Mosa), the level of anxiety and depression - by the HADS scaleResults. Patients with TBI consequences of varying severity established significant growth indicators charac- terizing the level of necrosis and apoptosis of peripheral blood leukocytes, and increase the percentage of cells containing active oxygen species. Reliable dependence of indicators RI + ANV + peripheral blood leukocytes and ROS + on patient’s age, duration and type of injury was not foundConclusions. Conditioned upon progression of neurological deficit (accession of extra-pyramidal symptoms, oc- currence and progression of cognitive disorders, etc.) significantly higher values RI + ANV + peripheral blood leukocytes and ROS+ were found