Features of the immune status in children with acute and chronic glomerulopathy
One of the main problems of modern clinical nephrology is the increase in the prevalence of glomerulopathy in childhood, renal pathological process tends to progress and develop irreversible changes that lead to chronic kidney disease and disability in pediatric patients. This research examined the features of humoral immunity in acute and chronic course of glomerulonephritis in children. It was found that the development of acute glomerulonephritis is characterized by the overproduction of immunoglobulins A, M, and G docked at the end of the first year. In contrast to acute glomerulonephritis, chronic one in manifistation period reveals the immune disorders which are more pronounced and persistent in the dynamics. The immune disorders are characterized by the increased content of immunoglobulin A and G, and continue during the first year of the onset. Based on the results, we can recommend the use of indicators identified as predictors of chronicity of glomerulonephritis in children.