THE ENCAPSULATION PROBLEMS. FLUORESCENT LABELS IN ORAL DELIVERY SYSTEMS OF PROTEINS
The efficacy of fluorescent labels (FL) for the study of oral protein delivery systems (DS) is discussed. The investigated DS are formed from porous CaCO3 cores covered by the method of polyelectrolyte layer-by-layer assembly. Another option for the formation of two-level DS is the inclusion of CaCO3 cores with proteins into alginate granules. FL allow visualizing the presence and distribution of labeled objects in delivery systems of different structures. On the examples of encapsulation of therapeutic proteins receptor antagonist of interleukin 1 and superoxide dismutase in DS of different structure the influence of FL on functional and structural characteristics of DM is estimated.