NEUROHUMORAL MODULATORS IN THE TREATMENT OF PATIENTS WITH CHRONIC-TION HEART FAILURE
In this literature review presents the main data on neurohumoral concepts of the pathogenesis of chronic heart failure (CHF). The influence of the basic groups of drugs, such as inhibitors angiotensinase enzyme inhibitors, blockers of beta-adrenergic receptors, blockers of receptors of angiotensin II, on the main links of pathogenesis, in particular on the activity of the renin-angiotensin-aldosterone and sympathetic-adrenal systems, the activity of neurohormonal factors of regulation of the cardiovascular system as well as their primary regulatory effects on myocardial function, status, intracardiac, coronary and systemic hemodynamics, adaptive and pathological effects on the heart and blood vessels. Identified the feasibility of application of preparations of these groups because of their diverse influence on the processes of remodeling and myocardial fibrosis. Examine the issue of differential approaches to the treatment of CHF, especially in cases with the combination of different in the pathogenetic understanding of the processes.