The disorders of the activity of ferments of the first phase of biotransformation of children with chronic viral hepatites C and B.
The disorders in the first stage of biological transformation's enzymes functioning have been studied, but the scientific research in children with chronic viral hepatitis C and B are few. This study includes investigation of 88 children with chronic viral hepatitis C (54 cases) and B (34 cases) in clinic of the upper gastrointestinal tract pathology, Federal State Establishment «Nizhniy Novgorod Research Institute of Children's Gastroenterology», Nizhniy Novgorod. In blood serum we detected alcohol dehydrogenase activity according to A. Shimasue, M. Murakami, T. Tsubokuro, and aldehyde dehydrogenase activity by the use of direct reaction according to the B.M. Kershengolts and E.V. Serkina method. In children with liver chronic viral inflammatory diseases the changes of liver enzymes activity were established, irrespective of their etiology. We established the direct and backward alcohol dehydrogenase level increase (p=0,005: p=0,007) and aldehyde dehydrogenase level decrease (p=0,038). These disorders can lead to endotoxicosis development and substantiate the therapeutic correction necessity.