Antibacterial and immobilizing properties of the new adhesive composition containing the nanoparticles of silver under the therapy of surgical wounds
The data on the investigation of antibacterial activity of the new adhesive composition designed for the immobilization of the lips of surgical wounds with regard to the pathogens of the wound infection are presented. Used in the experiment was the adhesive composition containing the nanoparticles of silver stabilized on the titanium dioxide and developed in the Research Institute of Experimental Veterinary of Siberia and the Far East of the Siberian Federal Scientific Centre of Agrobiotechnologies of the Russian Academy of Sciences jointly with the Research Institute of Solid State Chemistry and Mechanochemistry of the Siberian Branch of the Russian Academy of Sciences. The given composition has been found to have a marked antibacterial activity regarding the pathogens of the wound infection that relate to the families of Staphylococcus and Streptococcus. Medical and preventive treatment efficiency of the adhesive composition has been confirmed in the experiment with white rats of the “Vistar” lineby making a skin incision 3 cm. long on their withers. The immobilization of the lips of surgical wounds has been done in different ways. The clinical condition of the animals has been observed for as long as 14 days. It has been found that a single application of the adhesive composition containing the nanoparticles of silver in the dose of 0,5-1,0 mg/ cm2 produces a marked immobilizing effect on the lips of the surgical wound and prevents the development of postoperative complications in the form of wound infection.