COPEPTIN AND BIOMARKERS OF INFLAMMATION IN PATIENTS WITH DIFFERENT VARIANTS OF ACUTE CORONARY SYNDROME
We Investigated the clinical and diagnostic value of copeptin and matrix metalloproteinase 1,2,3,7 and TIMP1 in patients with mi and unstable angina. Copeptin concentration was estimated in comparison with known markers of myocardial damage (troponin, CPK MB) in the first hour of admission and after 6 hours. The level of MMP was determined in the 1st to 6th day of hospitalization. It is revealed that the concentration of copeptin in the patients with myocardial infarction was significantly higher than control group and was higher than in unstable angina. In the dynamics after 6 hours showed a significant increase of concentration of copeptin in the group with myocardial infarction without significant changes of its level in unstable angina. Of the studied metalloproteinases to a greater extent responsive to myocardial damage, earlier remodeling and intravascular inflammation appeared TIMP, MMP 1, MMP 7. Revealed a direct correlation interrelation in the group with infarction level copeptin with troponin I, CPK MB, morphofunctional parameters of the heart, MMP 1,2,3 and 7, the reverse with an index of GFR. Taking into account the obtained regression data determination of MMP 7 may as an additional marker of myocardial damage. The obtained data indicate the possibility for the diagnosis or exclusion of myocardial damage using the definition of copeptin in the first hour of hospitalization with the assessment of the initial absence of the increase in its level after 6 hours. As an additional marker of myocardial damage and possibly the use of MMP 7.