No metabolites impact in allergic inflammation regulation and their contribution to remodelling bronchi mucous in bronchial asthma patients
Background. To study the role of NO metabolites in allergic inflammation regulation and remodelling in BA patients. Material and methods. Morphological and morphometrical methods of investigation of bronchi mucous of 39 BA patients were used, IL-4, TNF-α, INF-g, IL-8, nitrite, 3-nitrotyrosine, nitrosoglutathion levels in bronchoalveolar washout were investigated, nitrite concentration in condensate of the exhaled air was measured. Results. The increased level of IL-4, TNF-α, INF-g, IL-8 in bronchoalveolar washout is associated with persistent Th2-inflammation. The BA severity correlate with highest IL-8, TNF-a, INF-g, nitrite and 3-nitrotyrosine level but with nitrosoglutathion deficit and in general is associated with structured architectonics bronchi mucous abnormalities. Conclusion. The association of toxic NO metabolites, pro-inflammation cytokines levels, bronchi mucous path-omorphological abnormalities with clinical signs of BA confirms the role of toxic NO metabolites in development of Th2-inflammations.