On some aspects of obesity and metabolism genetics in children and adolescents
A clinical-genealogical analysis of 468 children aged 1 to 15 years with constitutional exogenous obesity was held, data for about 6 788 relatives of obese probands has been collected. As pain control was studied the pedigrees of 100 healthy children and information about 889 their relatives. With all family situations and options for the transfer of body type the dependence between the body weight of probands and body weight of the parent whose morphotype it inherits were revealed. Constitutional exogenous obesity in children is characterized by the gradual appearance and progression of metabolic and hormonal disorders. Obesity, a pathological symptom, passed down from generation to generation, has a certain functional and morphological structure. Its implementation can be carried out only if the total accumulation of genetic and nongenetic (environmental) influences is 'safe’ for the manifestation process.