Impact of bacterial lipopolysaccharide - pyrogenal on a regression of liver fibrosis in chronic hepatitis C
Material and methods. A laboratory and morphological study of 29 patients with a relapse HCV after antiviral therapy, treated with pyrogenal, was conducted. Results. Against the background of pyrogenal injection for 1 year, more than 20% of the examined patients have had lower levels of direct serum markers of liver fibrosis (HA, and TIMP-1). The results of morphological examination of liver biopsy samples showed a decrease in the degree of sclerotic changes in the liver, reducing the thickness and number of sept, architectonic organ recovery (disappearance of false lobules), as well as stimulating the regeneration mechanisms in hepatocytes. Conclusions. Injection of pyrogenal to patients with a relapse HCV after antiviral therapy helped to inhibit the fibrogenesis and activate the mechanisms of fibrolysis in the liver, stimulate the regeneration of the liver tissue.