USAGE OF DECELLULARISED CONDUITS IN THE BIOPROSTHETICS OF VESSELS
This research is dedicated to the potential of applying the decellularised vascular conduits for the bioprosthetics of vessels. A human brachial artery was used as the material for the fabrication of the conduit. The artery was taken from a dead body with a death prescription of less than 3 hours. The preparation of the vascular biological prosthesis was conducted by the decellularization method with the using of 1% water solution of sodium lauryl sulfate. The implantation was carried out on the 15 mongrel dogs and consisted of the prosthetics of an incised part of the infrarenal abdominal aorta with the fabricated conduit. According to the results of the research, after the renewal of the blood flow through the aorta the anastomoses with the conduit were hermetic in all cases. The wall of the prosthesis was resistant to the hemodynamic load and did not transude with blood. In 14 out of 15 cases the investigated animal favorably bore the operative treatment (1 dog died because of the septic complications and was excluded from the research). In other 14 cases the femoral artery pulsation was observed during the whole time period till the day of the conduit taking. Accordingly to the histologic examination the biological prosthesis was endothelialised along the entire length in 14 cases. In conclusion it should be mentioned that the using of decellularised vascular conduits is a promising method and need more detailed study with the higher sample size and the longer time period between the implantation and the taking.