ACTIVITIES OF ANTIOXIDANT ENZYMES IN RED BLOOD CELLS AND SOME IMMUNOLOGICAL PARAMETERS OF BLOOD SERUM IN PATIENTS WITH SCHIZOPHRENIA-RELATED DISORDERS AND AFFECTIVE DISORDERS: COMPARATIVE STUDY
The aim: to compare the glutathione reductase (GR), the glutathione-S-transferase (GST), the leukocyte elastase (LE) and the α1-proteinase inhibitor (α1-PI) activities and the level of autoantibodies to the S-100b (a-S100b) in blood serum in patients with schizophrenia-related disorders and affective disorders. Methods. 22 patients aged 18-25 with attack-like progressive schizophrenia (group 1), schizoaffective disorder (group 2) and affective disorders (group 3) were examined. Control group consisted of 20 healthy people of the same age. GR, GST activities in red blood cells and LE and α1-PI activities in serum were measured spectrophotometrically. The a-S100b level in the serum was assayed by ELISA. Results. Activities of GR, LE and α1PI were increased in all groups in comparison with controls. GST activity was increased only in group 2. Significant variations in LE activity were observed between group 1, 2 and 3. The higher LE activity in group 1 was observed. Our results provide support for further research of studied biological parameters and their relationship with pathophysiology of mental disorders.