EVALUATION OF THE INFLUENCE OF MERCURY (II) CHLORIDE ON THE EXPRESSION OF LUNG DAMAGE IN RATS WITH PERFLUOROISOBUTYLENE INTOXICATION
Intoxication with perfluoroisobutylene (PFIB) leads to disruption of the structure and function of the respiratory section of the lungs, which leads to the release of fluid from the systemic circulation into the interstitial and alveolar space with the formation of toxic pulmonary edema (TPE). Transcellular transport of water across the air-blood barrier (ABB) is carried out through a selective water channel, aquaporin-5 (AQP5). Water permeability through AQP5 is blocked by mercury ions. Thus, the use of mercury (II) chloride can reduce the severity of toxic pulmonary edema during perfluoroisobutylene intoxication.