COGNITIVE FUNCTIONS IMAPIREMENT IN PATIENTS WITH ACUTE ALCOHOL INTOXICATION AND THEIR TREATMENT WITH ANTIOXYDANT DRUGS
According to the reports from the majority of toxicological centers acute ethanol poisoning is dominated among the other intoxication. The aim of the study was to investigate the cognitive function of 48 patients with acute alcohol intoxication, classified by Mini-mental State Examination (MMSE) scale with the use of drugs with antioxidant activity. Patients were randomized into 4 study group: group I (n = 12) with standard therapy of alcohol poisoning, in group II (n = 12) – additionally glycin 1500 mg/day, in group III (n = 12) – 20 ml cytoflavin intravenous 2 time a day and glycin sublingual 1500 mg/day, in IV group (n = 12) – mexidol 250 mg intravenously 2 times a day and glycin 1500 mg/day. It is shown that the most effective was the application in addition to standard therapy a combination of glycine, mexidol, which allows to achieve to the third day the full recovery of mental functions and toxic effect of ethanol.