PATHOMORPHOLOGICAL ASPECTS OF ADRENAL INVOLVEMENT IN THYROTOXICOSIS
The purpose of the work was to study the pathomorphological pattern of the adrenal gland at rats under experimental thyrotoxicosis. 44 clinically healthy, mature white male rats of the Wistar line weighing 170-180 grams were divided into two groups: an experimental (a thyrotoxicosis model) and a control one. Animals were withdrawn from the experiment on 7, 14, 21, 28, 35, 42, 49, 56, 63 and 70 days with the definition of thyroid hormone and thyroid-stimulating hormone in the blood and microscopic examination. The first signs of thyrotoxicosis were observed on the 7-14th day, the unfolded picture of thyrotoxicosis developed on the 21st day of the experiment. Changes from the adrenal glands included focal and diffuse lesions of endocrine cells of the brain substance, and then cells of the cortex. After 70 days of the experiment, lysis of the adrenal medulla was observed.