WARTHIN-LIKE PAPILLARY THYROID CARCINOMA ASSOCIATED WITH HASHIMOTO’S THYROIDITIS: CASE REPORT.
Defining histological variants of thyroid carcinoma has an important clinical implication as their progression, recurrence, aggressiveness, and prognosis differ from each other. Warthin-like variant is one of the rarest histologic variants of papillary thyroid cancer. After the ultrasound had been applied to diagnose a 44-year-old woman, cancer nodules up to 1.0 cm in diameter were found in both lobes, and ones up to 3.0 cm diameter - in the isthmus. Thyroid functional test showed Hashimoto’s thyroiditis. The patient underwent thyroidectomy. Microscopic analysis revealed tumor consisting of papillae lined by cells with eosinophilic cytoplasm, nuclear chromatin clearing, grooves, and pseudoinclusions amid diffuse nodular goiter in both lobes of the thyroid gland and in isthmus and a characteristic lymphocytic infiltration of the papillae cores. Warthin-like variant is a rare and insufficiently studied kind of papillary thyroid carcinoma, which is characterized by favorable prognosis. The implied difficulty of diagnosis is often connected to a combination of classical form with Hashimoto’s thyroiditis.