STROKE AS A CLINICAL FORM IN THE STRUCTURE OF CENTRAL NERVOUS SYSTEM LESIONS IN COVID-19 WITH FATAL OUTCOME
This article reviews the most relevant symptoms and complications of COVID-19-associated stroke with fatal outcome. The literature proves that SARS-CoV-2 is able to induce cytokine release leading to endothelial dysfunction, which may be accompanied by the development of acute cerebral circulation disorder (ACHD). The relationship between COVID-19, ONCC and comorbid risk factors contributing to stroke is revealed. On the basis of the pathogenetic characteristics of CHF, the retrospective analysis of 44 medical records of the inpatients was carried out, describing the disease onset, sex and age characteristics of the patients, clinical features of the nosological form, severity of the neurological deficit according to the recommended scales, and concomitant pathology. The structure of pathologic diagnosis and fatal complications were also considered. The method of investigation was statistical, using arithmetic mean in the sample. COVID-19-associated stroke with lethal outcome was found to be of ischemic stroke type, atherothrombotic and cardioembolic genesis. It occurs in the group of people over 61 years old, characterized by the development of a severe state with neurological deficit against the background of non-serious bilateral polysegmental pneumonia. The main risk factors are age, concomitant cardiovascular pathology. Among laboratory indexes, special attention should be paid to markers of adverse course: coagulogram, CRP, and blood glucose level.