Antiproliferative effect of matrix metal-loproteinases 9 and 13 in experimental cutaneous melanoma in vivo
Selective inhibition of matrix metalloproteinase-9 (MMP-9) and combined inhibition of MMP-9 and MMP-13 has modulated tumor growth in experimental cutaneous melanoma in vivo. Combined inhibition of MMP-9 and MMP-13 in cutaneous melanoma has reduced significantly the cell proliferation in comparison with that in the group with selective MMP-9 inhibition. This presumably indicates the regulatory role of metalloproteinases in tumor growth.