Evolution of the Use of Angiogenesis Inhibitors in Ophthalmology
The introduction of anti-VEGF therapy into clinical practice has given new opportunities to restore functionally significant vision in patients with retinal diseases, improving their quality of life and changing the treatment paradigm from maintaining visual functions to restoring them. However, such diseases as neovascular age-related macular degeneration and diabetic macular edema still remain the leading causes of visual impairment and high socioeconomic costs associated with them. The purpose of this review is to analyze the development of anti-VEGF therapy based on numerous publications with an emphasis on the immediate prospects. The latter may be associated with both advances in artificial intelligence and a personalized approach to treatment. A particular attention should be paid to the use of long-acting drugs and the search for new therapeutic targets that will be available over the next decade.