Interleukin-10 gene polymorphism in children with influenza complicated by pneumonia
The objective. To study the incidence of polymorphic marker genotypes of interkeukin-10 gene (G-1082A, C-592A, C-819T) in children in influenza A(H1N1/v) complicated by pneumonia. Patients and methods. A study of the incidence of IL-10 gene genotypes (G-1082A, C-592A, C-819T) was performed in 87 children with influenza A(H1N1/v) complicated by pneumonia, and in 50 children with pneumonia outside an influenza epidemic season A(H1N1/v). Results. Genotypes G/А of lL-10 gene G-1082A, С/А of IL-10 gene C-592A and С/Тof IL-10 gene C-819Tin children are associated with development of pneumonia irrespective of the etiological factor, without influencing the severity of its course. Severe pneumonia in influenza A(H1N1/v) is characterized by frequency of registering genotypes С/С (80%) and А/А (10%) of IL-10 gene C-592A as compared with pneumonia etiologically unrelated to influenza virus - 46.7% and 0%, respectively. IL-10 C-592A gene genotypes С/А and IL-10 gene C-819T С/Т genotypes in severe course of pneumonia in children with influenza A(H1N1/v) act as protective factors. Conclusion. Study of Il-10 gene polymorphism in influenza in children permits to predict formation of complicated forms of disease and specificities of their course in carriers of polymorphic molecules.