RISK FACTORS FOR MULTIPLE PRIMARY CANCERS
This work provides a review of Russian and foreign scientific publications. The phactors having an influence on multiple primary tumors were examined. The influence of sex, previous treatment, ionizing radiation, heredity, hormonal and metabolic disorders, immunodeficity status, environment, duration of cancer survivors observation, viruses are analyzed. The review also discuss the results of some cohort and epidemiological studies of multiple primary cancer incidence, age and gender peculiarities. Recent observations indicate that if the exposure to risk factors did not cease, the high risk of the second cancer development still exists. The work provides an explanation of the necessity of dynamic observation of the patients after the first cure.