STRUCTURAL AND FUNCTIONAL TRANSFORMATION OF WALL ILEUM AND LYMPHATIC ZONE CAUSED BY INTRODUCTION OF ANTITUMORAL DRUG "BORTEZOMIB"
Intraperitoneal introduction of antitumoral remedy "bortezomib (1kurs) to experimental rats causes structural changes in the walls of the small intestine, its lymph bearing ways and regional lymphoid structures. The identified transformations differ in term, severity and duration. Despite they indicate the increase of antigenic loading on the intestine lymphatic region; these changes have a reversible character in an intact organism.