Estimation of diagnostic value of the tests on antenatal components of hemoglobin spectrum
Selective immunochemical tests on embryonic and fetal hemoglobin types have been designed, characterized by specificity and having a high diagnostic and prognostic value for all the studied nosological groups. We have developed optimal algorithms for quantitative analysis of fetal and embryonic hemoglobins. We have also formed and successfully tested an integrated assessment algorithm of hemoglobin spectrum, including antenatal types of hemoglobin. The analysis of the diagnostic value of the proposed immunochemical tests showed high values of their sensitivity (threshold value of 1,73 ± 0,28 to 2,14 ± 0,19 mg/l), accuracy (± 1,2%), reliability (r = 0,97) and diagnostic efficiency (p < 0,001).