Effect of combination antihypertensive therapy on vascular stiffness in patients with arterial hypertension and increased rates of pulse wave velocity (PWV)
Аim. To assess the effect of six months effective combination therapy in patients with hypertension with increased rate of PWV. Materials and methods. The study included 60 patients with arterial hypertension and increased vascular stiffness. Assessment of the clinical status included the analysis of complaints, the results of biochemical blood tests, ambulatory blood pressure monitoring, Echocardiography, indicators PWV. Results. The study demonstrated the presence of a considerable number of risk factors and associated clinical conditions in this group of patients. 33 (55%) patients reached target values of PWV, 15 (25%) patients showed a decrease PWV but the values did not reach the target level. The importance of vascular stiffness remained unchanged in12 patients (20%) within six months of treatment. Conclusions. Appointment effective antihypertensive therapy helped reduce the PWV in six-month therapy.