CHARACTER OF CLINIC-LABORATORIAL DATA AND MORPHOLOGICAL CHANGES IN LIVERS OF PATIENTS WITH CHRONIC HEPATITIS C DIFFERENT DURATION
Objective. Establishing of the clinic-laboratorial and of morphological changes character in livers of patients with chronic hepatitis C (CHC) different duration having received no antiviral therapy was the purpose of the study. Materials and methods. Clinic-morphological examinations of 57 patients with different durations of CHC were conducted. Results. The most informative morphological changes in the liver (fatty dystrophy of hepatocytes, an inflammatory infiltration of portal paths, hyperplasia of Kupffer's cells and endothelium) which may be recognized as the most specific morphological signs of CHC irrespective of the illness duration have been established. In addition, their interrelation with the indicators of hyperenzymemia frequency (100%) being an additional criterion for prescribing an antiviral therapy for CHC has been proved. Conclusion. No fibrosis transformation in cirrhosis when the CHC course is characterized as the natural one is observed within 15 years from the infection when patients are not administered antiviral therapy.