Мonocyte Chemoattractant Protein Levels in Patients with Primary Hypothyroidism
Objective of the research - to study the content of monocyte chemoattractant protein-1 (MCP-1) in the urine of patients with primary hypothyroidism. Materials and methods. 141 patients with overt hypothyroidism have been examined. Among them, 71 patients had postoperative hypothyroidism, 70 - hypothyroidism on the background of autoimmune thyroiditis (AIT). Patients were divided: into I A group consisted of 35 patients with hypothyroidism following AIT without obesity; I B group - 35 patients suffering from AIT with hypothyroidism and obesity; II A group - 34 patients with postoperative hypothyroidism without obesity; II B group - patients with postoperative hypothyroidism and obesity. Results. The surveyed patients had significant increase of MHP-1 levels in all groups. During correlation analysis, we have established a direct correlation between levels of MHP-1 and thyroid-stimulating hormone, as well as creatinine levels in the blood and the reverse correlation of medium strength between glomerular filtration rate and concentration of MHP-1, with the highest severity in the uncompensated hypothyroidism on the background of AIT with obesity. Conclusions. Identified correlations indicate that the level of MHP-1 to a certain extent reflects renal function and can be used as a complement to traditional methods of examination of patients.