Lornoxicam effect on emostasis in patients after craniotomy in early postoperative period
Lornoxicam, one of NSAIDs, is considered as effective medication for postoperative analgesia. One of the well-known side effects of NSAIDs is hypocoagulation which can be dangerous in neurosurgery. The goal of this study was assessment of lornoxicam influence on hemostasis in perioperative period. Materials and methods: 20 patients after craniotomy for tumor removal were enrolled in the study. Lornoxicam was used in “scheduled” dosing mode: 8 mg during anesthesia induction, followed by 8 mg each 8 hours for 3 days. TEG and PFA analysis were used for hemostasis assessment on 0,1,3 and 5 days of perioperative period. Results: We didn't detected hypocoagulation in patients during the study. Moreover we noted a tendency for hypercoagulation in early postoperative period. It can be explained by hemostasis activation by intraoperative trauma. This effect is seemed more significant than hypocoagulation effect of NSAID in our group of patients. Conclusion: “Scheduled” dosing of lornoxicam don't inhibit hemostasis in neurosurgical patients.