ACTIVITY OF PROCALCINOGENIC AND ANTICALCINOGENIC ECTOENZYMES IN ARTERIAL AND VENOUS WALLS OF RABBITS WITH ALLOXAN DIABETES
Diabetes development is often complicated by arterial calcification i.e. Monckeberg's arteriosclerosis. This process can be caused by disbalance between factors of a vascular wall which promote (procalcinogenic) and interfere (anticalcinogenic) with deposit of calcium salts in tissues. Anticalcinogenic properties in a vascular wall are presented by pyrophosphate (PP ) which concentration depends on activity of ectoenzymes - ectonucleotidases and alkaline phosphatase. Ectonucleotidases hydrolyze extracellular adenine nucleotides and are the main source of PP in blood vessels. The alkaline phosphatase breaks down PP and reduces the content of this compound ini iitissues. The change of interrelation between these enzymes can result in reduction of PP concentration in the vascular wall and causeits calcification.