THE ROLE OF TROMBOPHILIA AND FOLATE DEFICIENCY IN THE GENESIS OF PREGNANCY LOSSES
The article presents an overview of modern views on the problem of pregnancy loss against the background of existing genetic or acquired thrombophilia and folate metabolism disorders. Many researchers have identified thrombophilia as one of the leading causes of adverse pregnancy outcomes - miscarriage, preeclampsia, fetal growth restriction syndrome, antenatal fetal death, etc. There is also evidence that folate deficiency and genetic polymorphism of folate cycle enzyme genes leads to hyperhomocysteinemia, which in turn also contributes to the development of hypercoagulation. Modern views on the problem show that each of the presented pathological processes, and more often their combination, lead to pregnancy loss at different gestation periods.