METHOD OF INDIVIDUAL SELECTION OF PREMEDICATION BEFORE THYROID SURGERY
The aim of the work was to develop a method for the individual selection of premedication before thyroid surgery, taking into account psycho-vegetative reactions. In all patients, psycho-vegetative and hormonal status, as well as hemodynamic parameters and bispectral index were evaluated in the evening before surgery and prior to admission to the operating room. All patients were divided into three groups and received different drugs for premedication (hydroxyzine, diazepam and midazolam, respectively). The positive effect of premedication was assessed by reducing the level of situational and personal anxiety, severity of anxiety symptoms, blood cortisol level and hemodynamic stability during surgery and anesthesia. In order to develop the tactics for choosing the optimal drug for premedication with the identification of the most significant predictors, discriminant stepwise analysis was performed. As a result, three discriminant models were developed to select one of the three types of premedication based on hydroxyzine, diazepam or midazolam. When carrying out an individual selection of premedication for thyroid surgery, it is necessary to use a multifactorial value, which includes an assessment of the psycho-emotional status of patients using the Spielberger-Hanin scales, HADS score and the serum level of thyroid hormones, thyroid - stimulating hormone and cortisol.