STUDYING OF ANTIULCEROUS ACTIVITY OF COMPLEX PLANT EXTRACT AT THE EXPERIMENTAL STOMACH ULCERS
In the work the results of studying of antiulcerous activity of 8-complex plant extract on the pilot models of stressful, acetilsalicylic and butadionum stomach ulcers at introduction of per os of extract in a dose of 150 mg/kg are presented to laboratory animals. Experiments are executed on 120 non-linear rats males and 164 not purebred mice males. The methods with assessment of acute toxicity, definition of the index of Pauls, the index of the antiulcerous action - the main criteria for evaluation of antiulcerous activity of medicinal preparations were used. It was shown that at stressful ulcers the effectiveness of extract is characterized by decrease of large, pointwise ulcers, decrease in quantity of cankers at mice, the index of the antiulcerous action = 4,6. It is established that at acetilsalicylic model of stomach ulcers against the background of introduction of extract of an ulcer found only in 67% of animals, observed less expressed damages mucous a stomach, the index of the antiulcerous action makes 4,5. In the conditions of butadionum model it is revealed that introduction of extract limits the formation of ulcer defects which is most expresse butadionum d for 14 and 21 days of observations, the index of the antiulcerous action is equal to 3,4. The received results demonstrate antiulcerous activity of complex plant extract somewhat surpassing effects of medicines of comparison of befunginum and ranitidine.