Adequate diagnostic criterion of the development of the inflammatory process in chronic pancreatitis in dogs
Most modern methods of diagnosis of chronic pancreatitis based on the detection of the phenomenon of "escape of the enzyme", but the resulting data do not always reflect the complete picture of the pathological process, it could therefore be argued that the definition of the reaction antitripsina buffer systems of blood is the most adequate criterion for the diagnosis of the development of the inflammatory process affecting the tissue of the pancreas, in chronic pancreatitis in dogs. As a result of our experiment was developed by the diagnostic drug of the extract of the duodenum of the pig, containing secretin and cholecystokinin, and performed its testing in rats and dogs. Based on the bacteriological, histological studies of the tissues of the pancreas and duodenum, as well as biochemical studies of blood of rats it was found that the received diagnostic drug, is sterile, non-toxic and does not have cumulative properties. So in the implementation of the introduction of a diagnostic drug observed activation antitripsina buffer systems of blood, the effectiveness of which is determined by the change in the concentration of circulating in blood in rats, а1 -antitrypsin, the amount of which is reduced to 0,25 g/l. The concentration of а1-antitrypsin in the blood of clinically healthy dogs before pancreatic stimulation diagnostic injection was 2,25 g/l, after stimulation of the pancreas - 1,75 g/l, but these changes kratkovremennoe. Therefore, our proposed diagnostic drug obtained from the extract of the duodenum of a pig, leads to a change in the volume of circulating inhibi tors of proteolytic enzymes in serum, blocking the proteolysis of the inflammatory process in the tissues of the pancreas, and can act as a reliable metabolic adequate method of diagnosis of chronic pancreatitis in dogs.