Microelectrode registration of neuronal activity in treatment of Parkinson’s disease using the method of stereotactic thermal destruction of deep brain structures
Objective: to present the functional results of stereotactic thermal destruction of basal nuclei with the usage of microelectrode analysis at such patients. Material and methods: We operated on 55 patients with lateralized forms of Parkinson’s disease at the base of в Novosibirsk Federal Neurosurgical Center within 8 months in 2013. We performed 26 ventral dorsal pallidotomies and 29 ventral intermediate thalamotomies. The sequential steps of intraoperative microelectrode registration of neuronal activity of basal nuclei and clinical testing are presented. Results: The usage of the mentioned method allowed significantly improving the life quality at patients with such pathology (PDQ-39 and UPDRS scales) by 73% in general. There were no lethal outcomes, 2 (3,6%) patients had perioperative complications: temporary dysarthria and hypertensive inctracerebral hemorrhage on the 2d day after thalamotomy. Conclusion: the usage of neurophysiological navigation system allows conducting stereotactic deconstructive operations more safely at the new submillimeter accuracy level as well as achieving maximal clinical effect and decreasing the risk of complications for each patient personally, whereas only anatomical orientation is possible during neurostimulation procedures.