POLYMORPHISM OF THE CYTOCHROME P450 GENE CYP1A1 (ILE462VAL) IN DESCENDANTS OF MIXED MARRIAGES OF TUNDRA NENETS WITH RUSSIANS
The work concerns a polymorphism of the cytochrome Р450 CYP1A1 gene, the CYP1A1*2C variant (Ile462Val, rs1048943). The transmitter of the 462Val variant sharply increases possibility of mutational changes DNA and can be the factor of risk of development of row of oncologic and other multifactorial diseases. This study was performed in Purovsky and Tazovsky districts of the Yamalo-Nenets Autonomous Okrug. The cohort consists of descendants from the mixed marriages of Tundra Nenets with Russians. Genotyping was performed using Real-Time PCR with competitive TaqMan allele-specific probes. The frequency of the 462Val allele in metises cohort was 18,7 % which is higher than frequencies found in European populations (2-6 %), but low than East Asian (25 %) and native American (35 %) populations. The frequency of the 462Val allele in metises cohort also low than frequencies found in Tundra Nenets (23,8 %). This fact allows to consider mixed marriages of Tundra Nenets with Russians, as a positive factor for adaptability of native populations of North to the changing terms of dwelling.