Integrated evaluation of proinflammatory and anti-inflammatory interleukins level (inflammatory markers) in patients with chronic obstructive pulmonary disease depending on the severity of the disease and age of patients
The results of the study of inflammatory markers in 163 patients with chronic obstructive pulmonary disease (COPD) are given in the article. The aim of the study was to examine the levels of proinflammatory (IL-1β, TNF-α) and anti-inflammatory (IL-10) interleukins in serum of patients with COPD according to the severity of the disease and age of patients. These results indicate that the disease is accompanied by marked changes in cytokine system which manifests itself as a rise of pro- (IL-1β, TNF-α), and anti-inflammatory cytokines (IL-10) concentration. We observed an increase in levels of IL-1β, TNF-α and IL-10 in serum with the progression of COPD. Amount of IL-1β and TNF-α in the serum of patients increases, and IL-10 - decreases with increasing the age of the patients.