ASSESSMENT OF BIOCHEMICAL INDICATORS CHARACTERIZING THE HEALTH STATUS OF THE POPULATION OF THE EAST KAZAKHSTAN REGION EXPOSED TO RADIATION DUE TO NUCLEAR WEAPONS TESTS
Introduction: In 2017, the scientific program "Development of scientific and methodological foundations for minimizing environmental burden, medical provision, social protection and health improvement of the population of ecologically unfavorable territories of the Republic of Kazakhstan" was started in the SMU. In the framework of the program we studied the state of health and nonspecific resistance in the population of the East Kazakhstan region exposed to radiation. Aim: assessment of biochemical indicators characterizing the health status of the studied population Methods: The sample size in the Abay region was 222 people, in the Borodulikha district it was 233 people, in the Kurchumsky district it was 245 people. Biochemical indicators (calcium, potassium, sodium, magnesium, glycosylated hemoglobin, total protein, ALT, AST, thyroid hormones, antibodies to TPO, ACTH, cortisol, insulin) were studied. Inclusion criteria: age 18-50 years, legally confirmed residence in the territory of the influence of the Test Site. Exclusion criteria: organic lesion of the central nervous system, somatic diseases in the stage of decompensation. Control - residents of the Kurchum district. The design is cross-sectional study. Statistical processing: IBM SPSS Statistics 20, with the definition of the normality of the distribution of the studied characteristics and the evaluation of descriptive statistics of numerical variables. Qualitative variables are represented in the form of absolute figures and their percentages. Evaluation of differences in groups is determined by calculating the χ2 criterion. Results. High levels of thyroid-stimulating hormone were found in the residents of Borodulikha district (13.5%), in Abai district it was defined in 3.9% of residents. The excess of antibody titre to TPO was recorded in both study groups (80.09 in Abai and 43.77 in Borodulikha districts). Signs of violations of nonspecific resistance manifested in the changes of the blood microelements (decrease of magnesium, calcium and potassium), increased cortisol. Conclusion: Biochemical indicators of violations of nonspecific resistance in the persons exposed to radiation have been established.