MORPHOBIOLOGICAL FEATURES OF METAPLASTIC BREAST CARCINOMA
We have done the comparative morphoimmunohistochemical study of metaplastic carcinoma (MC) of the breast. The following parameters were considered:vimentin, pancytokeratin, CK5/6, CKHMW, estrogen, progesterone receptors, Her-2/neu, Ki-67, cyclin D1, topoisomerase 2a, p53, E-cadherin, EGFR. It is shown MK is a rare tumor of the breast, has an epithelial-mesenchymal origin, basal-like phenotype with high proliferative activity of the cells. Described morphological characteristics MK breast cancer help to clarify drug therapy and the prognosis of the disease.