EFFECT OF SYSTEMIC ENZYME THERAPY ON HEALING OF VENOUS TROPHIC ULCERS
The article provides the data of the clinical study on effectiveness  of application of the systemic enzyme therapy in patients with varicose veins of lower extremities of C6 clinical class by CEAP classification. The study was conducted in 2 groups. In the major group (20 patients) the protocol of the conservative therapy included systemic enzyme therapy (Flogenzyme MUCOS Emulsions GmbH, Germany), the control group included only conservative therapy including modern wound coverings adapted to the stage of the wound process, elastic compression and micronized purified fraction of flavonoids. The duration of therapy was 1 month. As a result of therapy complete ulcer healing was registered in 18(90%) of patients, in the control group – in 9 patients (50%). The analysis of immune hemostasis values affecting the inflammatory process showed considerable reduction of absolute and relative content of CD4+CD25Bright-cells and increase of T-lymphocytes with phenotype CD4+CD45RO+ in the major group, which corresponded to the positive changes in the clinical pattern. Inclusion in the therapeutic protocol of the systemic enzyme therapy drug Flogenzyme contributed to quick regression of the clinical symptoms of the chronic venous insufficiency and acceleration of the process of regeneration of the venous trophic ulcers at stage I-III of the wound process.