Natural substances of marine origin as potential drugs for treatment of gram-negative sepsis and endotoxic shock
Results of investigation of substances of marine origin (lipid As, chitosans, carrageenan) as potential drugs for treatment of gram-negative sepsis are presented in the paper. Lipid As from Chryseobacterium and Marinomonas marine bacteria were found to have properties of endotoxin antagonists. Chitosans and carrageenan were shown to modify endotoxic activities of lipopolysaccharides. The obtained results permit us to consider the studied substances as potentially useful for treatment of clinical syndromes associated with endotoxins.