ANALYSIS OF THE CHANGE MECHANISMS OF THE RED BLOOD CELL (RBC) MICRORHEOLOGY UNDER THE EFFECT OF GASOTRANSMITTORS IN NORM AND TYPE 2 DIABETES
Gaseous mediators or gasotransmitters (GT) is a new class of signaling molecules involved in the regulation of a variety of body functions. However, little is known about their effect on the blood cell microrheological properties. For this purpose, a comparative study of the RBC microrheological characteristics was completed. Their deformability (DE) and aggregation (AE) after incubation with donors and stimulants of GT in healthy individuals and patients with type 2 diabetes were recorded. Statistically significant data were obtained on positive changes in RBC microrheology after cell incubation with GT. At the same time, not only differences in the RBC microrhreology of healthy individuals and diabetics were identified, but less pronounced microrheological responses of RBCs of diabetic patients to stimulation of GT were established.