EXPERT SYSTEM OF CELLULAR ATYPIA IN DIAGNOSIS OF THYROID DISEASES
Objective. To perform the expert system clinical trials and to assess its efficiency for the thyroid diseases malignant and benign forms differential cytological diagnosis. Material and methods. One hundred and twenty cytological preparations of patients with the confirmed cytological diagnoses of papillary and follicular cancer, follicular adenoma, autoimmune thyroiditis, nodular colloid and diffuse toxic goiters were selected for clinical trials. The cytological preparations selected were studied at a computer analyzer for color images based on the light microscope and digital camera. Results. The diagnosis verified by the expert system was determined to coincide with the histological conclusion in 104 (87%) cases of 120 ones. The diagnosis verification efficiency applying the expert system for the thyroid disease every nosologic form varied from 65% to 100%. At the same time the thyroid disease malignant and benign forms differential diagnosis efficiency was 99.2%. The latter result is very important for an adequate choice of the patient's surgical treatment volume. Conclusion. The clinical trials showed that the expert system elaborated basing on the function of the thyrocytes atypia qualitative signs transformation into the quantitative form allowed performance both the thyroid diseases main forms differential diagnosis and differentiation between their malignant and benign nature efficiently.