TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS (TREMg1): GENETIC POLYMORPHISMS AND A ROLE IN THE IMMUNE RESPONSES
Triggering receptor expressed on myeloid cells 1 type (TREM-1) belongs to the family of activating receptors expressed on cells involved in innate immunity. Activation of TREM-1 on neutrophils and macrophages plays an important role in inflammatory response enhancing. It is known that mutations in TREM-1 gene may lead to inappropriate responses in various pathological conditions, with both hyper- and hypoactive immune response. The authors analyze current scientific research works devoted to the present day understanding of the role of TREM-1 gene structural variation in the formation of various immunopathological states.