Antioxidant effects of metabolic protectors in experimental traumatic toxicosis
Traumatic toxicosis (crush syndrome) was modeled in rats by means of compression of smooth tissues of legs in special press apparatus within 4 h. The efficacy of succinate, 2-ethylthiobenzimidazol and their combination (25 mg/kg) administered intraperitoneally immediately after trauma (in decompression period) in traumatic toxicosis was studied. The toxicosis developing in 12 h after severe compression trauma was accompanied with activation of lipid peroxidation processes and inhibition of antioxidant systems in the liver. Systemic administration of succinate, 2-ethylthiobenzimidazol and their combination decreased the level of lipid peroxidation products (malonic dialdehyde and dienic conjugates contents) and increased the activity of superoxide dismutase and the level of recovered glutathione in the liver that indicated on defensive effects of drugs in the development of traumatic toxicosis. The addictive action of succinate and 2-ethylthiobenzimidazol allows recommend this combination as an effective and rational mixture to correct traumatic toxicosis subsequences.