Mechanisms of formation of the pathological process of multiple sclerosis and their methods of correction
Aim. To investigate glatiramer acetate influence on membrane stabilizing process and antioxidant protection in patients with remitting multiple sclerosis. Materials and methods. The article presents the results of a prospective (9-year) monitoring of 492 patients with multiple sclerosis from the point of view of the dynamics of indices of lipid peroxidation and activity of antioxidant defense system against the background of treatment with immunomodulatory action - glatiramer acetate. Results. It was found decline in lipid peroxidation and increased activity of the antioxidant system in the dynamics of observation were marked by the treatment with glatiramer acetate. Conclusion. The results are evidence of membrane action of glatiramer acetate and a pathogenetic point of view, justify its clinical benefit.