Influence smoking cigarettes on level of vascular cell adhesion molecule 1 (SVCAM-1), C-reactive protein and endocellular metabolism of neutrophils at healthy people
Influence smoking cigarettes on the contents of vascular cell adhesion molecule 1 (sVCAM-1), C-reactive protein in serum of blood and endocellular metabolism of neutrophils at 86 healthy people is investigated. It is revealed, that smoking is accompanied increase contents of С- reactive protein, growth quantity of neutrophils in peripheral blood and change of their functional activity shown in priming effect of cells membranous NADPH oxidase. The increase intensity of smoking (index of the smoking person more than 50 packs-years) at healthy people resulted in increase level of sVCAM- 1, i.e. development endothelial dysfunction, on background of the further increase quantity of neutrophils in peripheral blood and decrease in them activity of antioxidative protection (catalase and glutathione reductase).