RAT LIVER AT ADVANCED STAGES OF CARCINOSARCOMA WALKER 256
Investigation of Wistar rat liver cells on 7<sup>th</sup> and 14<sup>th</sup> day after carcinosarcoma Walker 256 implantation in thigh muscle was carried out. We revealed correlation of nonspecific endogenic paraneoplastic intoxication manifestation with blood and lymph circulation disturbances and liver parenchyma and stroma morphometric data changes at different periods. Distant tumor influence leads to necrosis, dystrophy and apoptosis of liver cells, contributes to terminal thrombotic angiopathy and causes compensatory reactions lowering on 14<sup>th</sup> day because of disintegration and cell death.