Glioblastoma molecular and histological heterogeneity
The heterogeneity of tumors properties is a serious diagnostic and therapeutic problem. It is manifested by the variability of genetic, proteomic and epigenetic parameters both between different samples of the same histological variant of the tumor, and between different sites within the same neoplasm with the presence of heterogeneous cell populations in this particular patient. Glioblastoma (GB) is one of the most frequent fatal tumors of the central nervous system in humans. The understanding the intertumor heterogeneity is the key to the development of both new diagnostic approaches and innovative personalized methods of patients’ management. In the framework of this review, the main data on intertumor heterogeneity of GB are summarized. The basic genetic, epigenetic and proteomic aspects of the modern understanding of GB molecular profile and intertumor heterogeneity are considered.