Phosphate, kidneys, bones and cardiovascular system
Recent studies have clearly linked higher serum inorganic phosphate (Pi) concentrations and an imbalance of Pi-regulating kidney-bone-parathyroid endocrine and paracrine systems to cardiovascular disease (CVD) events and mortality. This association has been identified in patients with chronic kidney disease (CKD) and in the general population. This editorial discusses the available clinical and experimental data in frames of the conception linking pathophysiology of phosphate exchange disorders related to CKD and CVD events.