Portal hypertension associated angiogenesis assay in experimental studies (literature review)
The review presents literature data on portal hypertension associated angiogenesis assay in experimental studies. The information was collected from the PubMed database, the Google Scholar retrieval system, and the reference lists from relevant publications for 1981 - 2017 using the keywords: “portal hypertension,” “jCT,” “angiogenesis,” “immunohistochemistry,” “intravital microscopy,” “microspheres.” Analysis of the literature showed that intra- and extrahepatic angiogenesis assays, such as micro-computed tomography in vivo and ex vivo, intravital microscopy, and computer image processing allow us to establish its important role in portal hypertension pathogenesis. The development of anti-angiogenic therapy, which would be focused on newly formed vessels, may be a perspective direction in the treatment of portal hypertension and its complications