THE USE OF CYTOFLAVIN IN COMPLEX TREATMENT IN PATIENTS WITH SEVERE COMBINED TRAUMA
Is studied the influence of substratal antihypoxant of cytoflavin on the clinical flow of sharp and early the period of traumatic disease. It is inspected 40 patients at the age from 18 to 60 the years of those entered with the diagnosis plural injury and shock 2 and 3 degree. Patients with the prevailing injury of brain and with the chronic immunodeficient states were excluded from a study. We studied standard clinical and laboratory data, the level of hydrocortisone, procalcitonin, CD14+ monocytes and antigenpresenting mononuclears (CDHLADR+). It is shown that in the group receiving cytoflavin, on 5 days was noted reliable reduction in the indices of a system inflammation - Creactive protein and a quantity of leukocytes. We associate these changes with a decrease in the bacterial load. This is evidenced by the significantly lower content of CD14+ monocytes and antigenpresenting mononuclear cells (CDHLADR+) in patients of the main group compared with patients in the control group who did not receive cytoflavin infusions. Also in the group of patients receiving cytoflavin, the hemoglobin concentration index exceeded 100 g/l on the 5th day after the injury, in the control group the hemoglobin level reached 100 g/l only on the 10th day. The use of cytoflavin in the treatment of patients with concomitant trauma contributed to a decrease in the activity of inflammation and a decrease in the duration of posttraumatic anemia. There was a tendency towards a decrease in the number of severe infectious complications and a reduction in the length of stay of the victims in the hospital (5 figs, 8 tabl., bibliography: 9 refs).