THE ROLE OF GENETIC FACTORS IN PROSTATE CANCER
Prostate cancer (PCa) is the most common cancer in men. There are about 899 000 new cases and over 258 000 deaths because of prostate cancer worldwide each year. Nowadays, epidemiological studies confirm a key role of the various factors related on age, lifestyle and family cases in the PCa development. Genome-wide association studies revealed a large number of SNPs associated with PCa risk. There are also investigations of copy number variation, fusion gene expression, as well as targeted gene resequencing of candidate genes. Thus, the molecular genetic characteristics of the tumor become an essential component in selection of optimal therapy on a par with morphological verification and basic examination methods.