EFFECT OF LIGANDS OF CANNABIS-RECEPTORS ON LATENCY NOCICEPTIVE REFLEX AND AFFERENT IMPULSATION IN N.SAPHENUS OF NORMAL RATS
It was found that administration of CB-receptor agonist anandamide (AEA) in the dose of 20 or 30 mg/kg under the rat hindpaw skin decreased the afferent impulsation rate in n.saphenus and prolonged the latency of nociceptive reflex (LNR). Injection of 50 mg/kg evokes the shortening of LNR and skin afferent endings sensitization. Antagonist of CB-receptors does change the LNR and afferent impulsation rate in similar manner with 50 mg/kg of AEA.