Influence of variants of common rs9939609 single nucleotid polymorphism in FTO gene on Saint-Petersburg residents'' weight reduction
We describe the influence of allelic variants of the single nucleotide polymorphism rs9939609 gene in fat mass and obesity associated (FTO), the dynamics of weight loss in St. Petersburg residents with obesity who use various weight loss programs. It is known that the common rs9939609 single-nucleotid polymorphism in the FTO gene plays an important role in the weight gain and obesity development. AA-variant carriers have higher body weight than people with AT and TT variants. It is known that AA-carriers with sedentary lifestyle have higher risk of excess weight gain. However, the problem of rs9939609 variant effect on the anthropometric parameters changes in people participating in various weight reduction programs is not sufficiently studied. It was revealed that the genotypes of rs9939609 single nucleotide polymorphism of the FTO gene among the residents of St. Petersburg as follows: TT genotype - 31,48% TA genotype - 42,59% AA genotype - 25,93%. Thus genotypes among men is: TT genotype of -38,84%, AT genotype - 42,11% AA genotype - 21,06%. Among women: TT genotype - 28,67%, AT genotype - 42,88%, the AA genotype - 28,67%. A statistically significant difference between the distribution of genotypes were found on the floor. Prior to the program of weight loss anthropometric indices in carriers of genotypes AA, AT and TT did not differ significantly. It was found that the carriers of at least one A-allele when on diet showed more profound weight reduction than people with TT genotype. Combination of increased physical activity with diet attenuates the differences in anthropometric parameters improvement between rs9939609 genotypes.