Genetic predictors of development and remote outcome in myocardial infarction in young men
The aim of the research. To examine the association of single nucleotide polymorphisms (SNPs) rs10757278, rs1333049 and locus 9r21.3 with development and remote outcome of myocardial infarction (MI) in young men (under 45 years old). Materials and Methods. Were examined the Europeoids under 45 years old. 106 patients with MI [Me 42,0; Q25 36,0; Q75 44,0], including 97 (91,5%) men and 111 people without coronary heart disease (CHD) [Me 42,6; Q25 39,0; Q75 44,3], including 103 (92,8%) men. Period of the prospective study of patients was from 45 to 60 months (55,9 ± 4,7 months). Results. Was identified statistically significant association of rs1333049 and rs10757278 with MI. Odds ratio (OR) of MI in men with risk allele Crs1333049, was 2.62 [95% CI: 1,33-5,18], the risk allele G rs10757278 - 2,27 [95% CI: 1, 16-4,44]. At prospective examination of patients the presence in genotype the risk allele C rs1333049 was the marker of high risk of reinfarction MI in men OR = 1,25 [95% CI: 1,12-1,40] and acute coronary syndrome (ACS): OR = 1,44 [95% CI: 1,24-1,68]. Conclusion. Genotyping of rs1333049 may be used for stratification the risk of repeated infarction and ACS in the remote period after myocardial infarction in young men.