INFLUENCE OF GLYPROLINE-CONTAINIG MEDICATION "SELANK" ON NUCLEAR ORGANIZER REGIONS ACTIVITY IN DUODENUM EPITHELIUM OF WHITE RATS
The authors studied the effect of glyprolines-containing medication «Selank» on Nuclear Organizer Regions (NORs) activity in duodenum epithelium of white rats after traumatic brain injury. In this experiment, Selank was intraperitoneally injected to rats (first injection in 3 hours after traumatic brain injury) in a daily dose of 1 mg/kg for 5 days. The animals were sacrificed by decapitation on day 6. Parameters of NORs were evaluated by computer cytomorphometry on a complex image analyzer in duodenum epithelium of white rats stained using AgNOR technique. The area of duodenum epithelio-cytes nuclei, number of nucleoli, and total area of nucleoli above the nucleus were analyzed. The areas of the nuclei and NOR were calculated from measurements of 50 cells. Thus, traumatic brain injury reduces the activity of NOR in duodenum epitheliocytes in comparison with the control. Against the background of traumatic brain injury, peptide significantly increased the NOR activity.