THE ROLE OF HIF-1Α FACTOR IN THEDEVELOPMENT OF FETAL HYPOXIA
The article presents the data on the dependence of the expression of HIF - 1α factor on the presence of pregnancy pathologies. The information on the changes in the fetus born in a state of hypoxia is presented. The data from humane medicine on the action of HIF - 1α factor, induced by hypoxia, encoded by the gene of the same name, as well as on the different levels of expression of HIF - 1α in women with pathological pregnancy compared with its physiological course, are presented. Adaptation to hypoxia can be hereditary and manifests as the appearance of gene polymorphisms. There is also an increased expression of HIF - 1α in women pregnant for the first time compared with the women pregnant for the second, etc. time. The data on the effect of HIF - 1α on pathological angiogenesis and its participation in the development of ischemia are presented. The most famous methods of pharmacological correction of the hypoxic state by effecting HIF - 1 transcription factor are considered. For example, deferoxamine, which induces the DNA - binding activity of HIF - 1 and increases mRNA levels of erythropoietin, a hormone that affects erythropoiesis.