Positive chronotropic therapy and progression of heart rhythm and conduction disturbances
The paper analyses how atropine M-cholinergic antagonist affects heart automatism and conduction in rats aft er the ligation of the posterior interventricular branch of the right coronary artery. It focuses on the mechanism of paradoxical reactions to atropine when AV-conduction disturbances are present explaining how positive chronotropic therapy can help identify hidden SA- and AV-conduction disturbances.