Endothelium dysfunction and lesion in hepatobiliary pathology
The aim of work was to estimate the state of endothelium in patients with hapatobiliary pathology. Material and methods: 14 patients with cholelithiasis, 50-with chronic viral hepatitis, 30-with liver cirrhosis were examined. Nitric oxide, endothelin 1, desquamated endotheliocytes, von Willebrand factor were determined in blood plasma. Results and discussion: Decrease in nitric oxide content (15,8±3,7 mcmol/l, p=0,001, diagnostic sensitivity of test - 95%, specificity - 90%) and heightening of endothelin 1 concentration (0,74+0,18 fmol/l, p=0,001) was revealed in patients with hepatobiliary pathology that confirms presence of epithelial dysfunction signs in the given pathology and contributes to disturbance of hepatic circulation. Indices of endothelium lesion including the number of desquamated endotheliocytes and activity of von Willebrand factor were raised (p=0,001 and p=0,01, respectively). Maximal changes were detected in liver cirrhosis, moderate-in chronic hepatitis, minimal ones - in patients with cholelithiais; differences between the groups were reliable. Conclusion: The indices investigated have good diagnostic efficiency for revealing lesions of endothelium in hepatobilliary pathology.