Impaired vaginal microbiocenosis as a determining factor of modification of mucosal immunity
According to current views, bacterial vaginosis (BV) is defined as disease associated with impairment not only of normal microflora but also of mucosal immunity of the vaginal system. The authors hypothesize that changes in congenital immune response are a cause of development of undesirable complications in women with BV, when nonspecific recognition of microorganisms by the immune system triggers antimicrobial immune defense and is under genetic control. Ethnic differences in not only the incidence BV, but also in a degree of immune responses to infection are noted. Therefore, modification of an increase of proinflammatory cascade might take place both owing to genetic factors of a macroorganism, and/or under the influence of microorganisms. Recently, there appeared evidence that a high incidence of relapses as well as serious complications observed in some women with BV might be modulated by specific genetic factors.