Angiogenesis mechanisms in transplantation of tissue-engineered constructions
There is a number of problems regarding bioengineered structures creation that require further study in the field of regenerative medicine. One of the critical tasks that require solution is the fact that tissue engineered constructions, as a rule, are large, which significantly limits the possibility of diffusion of nutrients and oxygen in them. Thus, the key task of fundamental medicine is to find a technology for restoring the perfusion of the structures created. The article presents a modern overview of the mechanisms of angiogenesis and possible ways of its stimulation during transplantation of tissue engineered constructions.