CYTOGENETIC EFFECTS OF THE PERIPHERAL BLOOD HIGH DOPAMINE LEVELS IN SHIFT WORKERS OF OIL FIELDS OF THE NORTHERN SIBERIA
125 men employed in the oil industry of the Tomsk and Tyumen Regions of Siberia, the Russian Federation, have been examined. The frequency of cytogenetic damaged cells (by the micronucleus test) and the peripheral blood dopamine levels were detected in shift workers and administrative staff (controls) of oil fields at the beginning and at the end (in a month) of the working shift. It has been found that the levels of the parameters are associated with the duration of the seniority in the oil fields. The highest levels of the indices are determined among the novices without the seniority at the end of the working shift. The correlation analysis is demonstrated the significant associations between the parameters in all groups of the workers except the individuals with the seniority more than 10 years. The activation of mutation process in the oil industry workers is presumed t6o be a result of combined effects of various factors on the genome including not only strong mutagens, but also co-mutagens.