PREDICTORS OF NON-DEVELOPING PREGNANCY AND ROLE OF PERICONCEPTIONAL CARE IN PREVENTION OF RECURRENT PREGNANCY LOSS
The goal of the research is to determine the main diagnostically significant causes of non-developing pregnancy, to evaluate the importance of periconceptional care. The research was carried out in Simferopol clinical maternity hospital No. 2 as well as Women’s Clinic in 2019-2020. 110 women with non-developing pregnancy and 50 pregnant women with no history of miscarriage or threatened miscarriage were examined. The patients’ medical history, including family history of miscarriage, the patients’ charts, periconceptional care availability and the results of clinical and laboratory studies were investigated. The results of the study were analyzed statistically with differences in p<0.05 being reliable. The main predictors of non-developing pregnancy in the patients of both the groups have been found out, such as: pelvic inflammatory diseases (anembryonic pregnancy, p<0.05), chronic pelvic diseases, such as endometritis, endocervicitis (non-developing pregnancy by the type of missed abortion, p<0.05), history of abortion artificial (non-developing pregnancy of both types, p<0.001), previous surgical interventions, such as conservative myomectomy, adhesion, thermocautery of abdominal endometriosis, ovarian resection, unilateral ovariectomy, salpingectomy (p<0.05). The embryo’ genetic and chromosomal abnormalities, the patients’ age are also significant. Extragenital disorders in the patients of the studied groups play an important role in the development of non-developing pregnancy as well. It has been confirmed that pre-pregnancy care allows for optimal conditions to enter subsequent healthy gestation and prevent recurrent pregnancy loss.