CHANGES OF PERIPHERAL BLOOD INDICATORS IN WHITE RATS WITH ACUTE TOXIC HEPATITIS ON THE BACKGROUND OF INTRODUCING WATER EXTRACTS OF HERBS CYMBOPOGON PROXIMUS, ACACIA NILOTICA AND TRIGONELLA FOENUMGRAECUM
On the model of acute toxic damage by carbon tetrachloride of the Wistar white rats, the effect of water extracts of the herbs Cymbopogon proximus, Acacia nilotica and Trigonella foenumgraecum was studied. It was shown that acute toxic damage causes the development of erythropenia, an increase in the average hemoglobin content in a separate erythrocyte, a decrease in hematocrit of leukocytosis, granulocytopenia, monocytopenia and lymphocytosis and thrombocytopenia. The toxic effect activates the peripheral lymphocyte pool of blood cells - its values increase by 65.3% in the series with the maximum dose of the toxicant. On the background of the introduction of Acacia nilotica, the incidences of lymphocytes and the development of absolute lymphopenia are recorded. Cymbopogon proximus Trigonella foenumgraecum increase the absolute values of lymphocytes. The introduction of aqueous extracts of Trigonella foenumgraecum and Cymbopogon proximus prevents the reduction of erythrocytes and the platelets activate the macrophage pool of peripheral blood. The macrophage components of peripheral blood (monocytes) decrease in control series in absolute value by 15.4%, in relative values by 57.9%. Phytopreparations significantly activate the monocyte cellular pool of peripheral blood. Acacia nilotica in the series with the maximum dose of the toxicant increases the number of monocytes by 42%, Trigonella foenumgraecum - by 30%. All investigated extracts of herbs corrected the decrease in platelets, but did not bring them to the indices of intact animals. Thus, aqueous extracts of the studied herbs stimulate the macrophage pool of peripheral blood cells against the background of acute toxic effects.