Medical diagnostic and therapeutic cellular-metabolic technologies in preventive gerontology and geriatrics - the results of work for 10 years
The article is devoted to review the work of the laboratory of anti-aging technologies of Institute for medical cell technologies for 10 years. The laboratory has implemented its activities in preclinical and clinical researches. In preclinical studies we investigated influence of the autonomic nervous system on dynamics of processes of lipid peroxidation in cellular (subcellular) structures in stress effects and possibility of correction of these changes using a combination of L-tryptophan and nicotinic acid. In clinical studies we have conducted researches of diagnostic biochemical predictors of aging and developed practical implementations of therapeutic anti-aging technologies. In this work it was developed the predictive program for selection of an effective individual personal, cell-based geroprophylactic therapy based on metabolic and functional parameters of a patient (mathematical model). We defined biochemical predictors of specialized cells aging of the endocrine system (T3) and cells of the nervous system of a human body (Protein S100). We developed age-related clinical methods of gas treatment (hypoxia, ozone therapy) and revealed geroprophylactic effect of L-arginine and Interleukin-2. It was shown that therapeutic massage can be considered as a promising non-invasive geroprophylactic technique. Oligopeptides (Lys-Glu-Asp, «Vezugen») and (Glu-Asp-Arg, «Pineolon») were last explored substances in the laboratory. They are able to increase expression of the genome, have geroprophylactic cell-oriented impact. It's one of the promising direction in the laboratory.