CHANGES OF BREATHING PATTERN AND RESPIRATORY RHYTHM VARIABILITY IN PATIENTS WITH BRONCHIAL ASTHMA
97 patients with bronchial asthma of different severity and 21 healthy volunteers were examined to determine the peculiarities of breathing pattern and rhythm variability depending on the presence and intensity degree of bronchoconstrictor reaction to cold air, the level of the disease control, phenotype and season of the year. The methods of spirointervalometry and bronchoprovocation test with cold air were used. A variability of volume and time parameters of the respiratory cycle and of respiratory center rhythm depending on the presence or absence of cold airway hyperresponsiveness, the level of control, severity, phenotype of bronchial asthma and season of the year was found out as the result of the study. The identified changes allowed to develop objective ways to determine the presence or absence of cold airway hyperresponsiveness in patients with bronchial asthma and to define the level of control over the disease.