WHEN TO BEGIN COMBINED THERAPY OF TYPE 2 DIABETES MELLITUS
Type 2 diabetes mellitus (DM2) is disease caused by insulin resistance and relative insulin deficiency. The article is dedicated to the modern principles of treatment of DM2 and hypoglycemic agents. One of the frequently used hypoglycemic agents is metformin, which can be combined with sulfonylureas in the case of ineffectiveness of treatment of DM2. The potentials for the use of Glucovance, combined tableted drug consisting of metformin and glibenclamide are discussed. Micronised form of glibenclamide in the Glucovance ensures the safety of the drug with high efficiency. This drug has less effect on β-cells, does not increase the fasting plasma insulin concentration, and reduces the risk of hypoglycemia. Affordability of Glucovance is important.