VIRAL RECEPTOR GENE EXPRESSION AND MYOCARDITIS DEVELOPMENT
Viral infection is considered as an important cause of myocarditis. Viruses most often found in the heart tissue of myocarditis patients are parvovirus В19 (36.6%}, enterovirus (32.6%), human herpesvirus б (10.5%} and adenovirus (8.1%}. The aim of the study was to investigate the expression of genes responsible for viral uptake and entry in myocardium in cardiac tissues and peripheral blооd cells.Extremely weak transcription was revealed by RT-qPCR analysis in endomyocardial blopsy samples from patients with myocarditis and control heart fragments for all target genes. GЬ4Cer gene was found to Ье strongly overexpressed in peripheral bloodcells of patients; expression of GЬ4Cer discriminates myocarditis and control groups with р = 0,006.Expression of CXADR was increased in З out of 10 patients Ьу а mean factor of 8,6; all these patients had dilated cardiomyopathy of inflammatory genesis. Expression of CD55, СD4б and XRCCS was not altered in peripheral blооd cell samples.ln this study we demonstrate а link between peripheral blооd cell virus susceptibllity and myocarditis development, providing а potential of РВС gene expression analysis for diagnosis of cardiac pathologies; potential blomarkers of myocarditis and dilated cardiomyopathy development are identified.