Types of multimodal analgesia in surgical treatment of colorectal cancer
Background. The purpose of the research was to study the efficacy and safety of various types of multimodal analgesia in the surgical treatment of colorectal cancer. Materials and methods. The study included 90 patients operated for rectal cancer. The analysis of changes in hemodynamics, stress marker level - blood sugar and pain intensity on the visual analogue scale was carried out in three groups of patients depending on the method of perioperative analgesia. Results. The study found that the application of various types of multimodal analgesia using epidural analgesia (EA) with inhalation and intravenous anesthesia more effectively protects the patient from surgical stress in colorectal cancer as compared to the total intravenous anesthesia, preserves hemodynamic stability, reduces the dose of fentanyl and muscle relaxants. Conclusions. EA with a mixture of local anesthetic with fentanyl, and EA with a local anesthetic with patient-controlled fentanyl analgesia in combination with a parenteral non-steroidal anti-inflammatory drug and paracetamol as components of multimodal analgesia is safe for postoperative use after colorectal surgeries, effectively controls acute postoperative pain, maintains a stable level of the blood sugar in comparison with postoperative omnopon anesthesia.