THE MAIN MUTATIONS IN THE rpoB, katG, inhA, ahpC AND gyrA GENES, CAUSING RIFAMPICIN-, ISONIASID-, AND FLUOROQUINOLONE-RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS CIRCULATING IN THE KYRGYZ REPULIC
The results of the study of the main mutations in rpoB, katG, inhA, ahpC and gyrA genes, causing rifampicin-, isoniazid-, and fluoroquinolone-resistance of mycobacterium tuberculosis circulating in the Kyrgyz Republic are presented. It was established that the fluoroquinolone-resistance of mycobacterium tuberculosis, circulating in the Kyrgyz Republic, is caused by the mutation of Asp94Gly gene gyrA. The resistance of MBT to rifampicin is due, mainly, to mutations in the 531, 526, 516 and 511 gene codons. The main mutation causing resistance of MBT to rifampicin is Ser531 → Leu of the rpoB gene, whereas the main mutation determining the resistance of MBT to isoniazid is Ser315 → Thr of the katG gene.