Effects of acute reversible occlusion of the cranial mesenteric artery on the dynamics of cellular immunity, and interleukin 6, 8
On the model of acute reversible occlusion of the cranial mesenteric artery studied the dynamics of IL-6, IL-8, cellular immunity correlated with the morphological structure of the small intestine wall. The experiment was conductedon 60 male albino rats weighing 0,2-0,22 kg. It was revealed that the acute occlusion of the cranial mesenteric artery isaccompanied by marked changes in the immune system and the development of systemic inflammatory response syndrome,which is compounded by reperfusion. At the same time the restoration of blood flow in the third hour of ischemia ischaracterized by minimal structural changes in the bowel wall with the stabilization of the total number of lymphocytesand the continued growth of proinflammatory cytokines. Reperfusion of the sixth hour of ischemia causes a decrease in theprogression of lymphocytes, increase in IL-6 concentration in the absence of necrotic changes in the intestinal wall. On theeighth hour of reperfusion ischemia leads to the progression of necrotic changes in the intestinal wall, the progression ofsystemic inflammatory response syndrome and further reducing the number of lymphocytes in the blood of experimentalanimals.