LONG-TERM RESULTS OF SURGERY IN PATIENTS WITH PULMONARY TUBERCULOSIS-NEGATIVE
The analysis of the occurrence of multidrug resistant Mycobacterium tuberculosis (MDR- ILO) in patients with pulmonary tuberculosis -negative, and the evaluation of the sensitivity and specificity of polymerase chain reaction (PCR real time) to determine the DNA Office of surgical specimens from these patients. Revealed a significantly greater efficacy of this method compared to the standard, as well as molecular genetic methods of detection of the pathogen in the sputum. The study showed the presence of more than a third of patients without bacterial isolation, the so-called latent MDR, which led to a drastic change of chemotherapy regimen, and the inability to determine in these patients DST Office, guided only by clinical and radiological data. Surgeries conducted in diagnostic patients, as well as reducing the time of chemotherapy before surgery in patients with a diagnosis of pulmonary tuberculosis approved-negative do not lead to deterioration of the prognosis of the disease compared with patients receiving long-term empirical chemotherapy, and can reduce treatment time and keep working capacity.