Predictive value of risk factors for periodontitis and assessment criteria of the flow of inflammation in periodontitis on the basis of molecular genetic tests
The article analyzes the predictive value of risk factors for periodontitis, the data obtained from a prospective observation of 150 patients. Evaluation of the flow of the process of inflammation was carried out according to morphological study. Saving inflammatory infiltrate in the background of the anti-microbial treatment stage, accompanied by marked clinical effect was regarded as "poor" outcome of therapy. Discriminant analysis of anamnestic, clinical, morphological and molecular genetic characteristics of patients allowed to calculate graduation factors predicting. The greatest predictive value is a predictor of "carrier 2R allele of the gene IL-1RN, IL-1 family". Following graduation in molecular genetics predictor is "3R allele of the gene IL-4 and the last one -" allele-308A * gene TNFα ». Of the predictors of having a digital expression, the greatest predictive value are: the "age" and "Limitation of the disease". This combination of predictors can provide the level of correct prediction in 79.8%.