BIOCHEMICAL AND PHYSIOLOGICAL MECHANISMS OF THE EFFECT OF SMOKING ON THE OXYGEN STATUS OF THE ORGANISME OF YOUNG MEN WITH DIFFERENT LEVELS OF PHYSICAL ACTIVITY
Consistency of oxygen transport system of the body, providing the current needs for oxygen, determined by the activity and interaction of physiological components of various ranks: respiratory, vascular and erythrocyte. The nature of these relationships undergo significant changes under the action of unfavorable factors. These include smoking, the main negative manifestation of which is to reduce the level of blood oxygenation. while developing adaptive responses aimed at increasing tissue oxygen delivery by including additional provisions in the oxygen system. However, the effectiveness of biochemical and physiological mechanisms of oxygen homeostasis depends on the life of the organism, including the intensity of physical activity, smoking faced by people. In this connection it is interesting to study the effect of smoking on the driving parameters of oxygen transport in young men with different levels of physical activity. Using analysis of variance we found that high physical activity is most important for the functioning of the cardiorespiratory system, and smoking affects the total red blood parameters. Under the influence of both factors are fractional composition of hemoglobin and p50. When smoking modified Hb affinity for O <sub>2</sub> mediated obviously Bohr effect by lowering the pH, during physical exertion, increased levels of tissue oxygenation. The net effect of these rearrangements in athletes-economization circulation at rest and during submaximal exercise stress. However, the combined effect of these factors affect the magnitude of pO <sub>2</sub>, characterizing the intensity of light absorption of oxygen consumption and its tissues. In addition, it was found that smoking in combination with intensive physical activity, shifting the basic homeostatic parameters – pH and blood circulation integral index - adaptatsioony potential causes disadaptative state of the organism.