CHANGES OF DAILY BLOOD PRESSURE MONITORING IN PATIENTS WITH ACID DISEASES
Objective: The purpose of this study was to evaluate and to compare the circadian characteristics of heart rate and arterial blood pressure in patients with acid-related diseases (ARD) associated with arterial hypertension (AH). 109 male patients aged between 19 and 57 years were included in to a study. Among them 20 patients had isolated duodenum ulcer disease (DUD), 20 patients suffered from gastroesophageal reflux disease (GERD), isolated AH was found in 25 patients. The combination of ARD and AH had been revealed in 44 patients. Standard clinical examination, as well as ambulatory 24-hours blood pressure monitoring with estimation of main circadian parameters of blood pressure and heart rate variability had been performed. It has been revealed that DUD exacerbation, as well as reflux esophagitis in patients with GERD, can cause heart rate disturbances and changes in circadian blood pressure profile even in patients without cardiovascular diseases. Associated diseases of gastrointestinal tract in patients with combination of ARD and AH may influence the AH and produce special conditions for increasing the risk of cardiovascular events.