GENETICS OF BRONCHIAL ASTHMA: POLYMORPHISM OF THE FCERI AND FCERII GENES-IMMUNOGLOBULIN E RECEPTORS
Scientists are actively conducting research to find candidate genes that cause the predisposition to bronchial asthma, as well as affect the pathogenesis and course of the disease. It is possible that their identification and subsequent study will allow predicting the expected response to antiinflammatory therapy, as well as the course of pathology.Objective: to conduct analytical review of the data of domestic and foreign literature devoted to the study of genetic aspects ofbronchial asthma; to study the frequency of distribution of alleles and genotypes of polymorphic markers of genes of the highaffinity receptor for IgE - FceRI and discouraging receptor to IgE - FceRII (CD23), determining their impact on the effectiveness of antiinflammatory therapy and the course of bronchial asthma in children.Material and methods: analysis of foreign and domestic literature.Results and conclusions. The analysis of the review of the literature data on the study of genetic aspects of bronchial asthma in children, allowed us to reveal that most of the research in this area was conducted abroad, unfortunately, there is little information in the domestic literature, which requires further study of such a promising and relevant area of medicine.