EVALUATING EFFICIENCY OF EXPERIMENTAL BURN WOUNDS TREATMENT WITH PECTIN FILMS CARRYING IMMUNOMODULATORY AMINOPHTHALHYDRAZIDE.
An experiment was made on 30 mongrel rats, to evaluate the effectiveness of pectin films carrying immunomodulatory aminophthalhydrazide in treatment of burn wounds. Wounds were created by a brass cylinder (weight: 300 g, contact surface area: 706 mm2) heated up to 100 0С in boiling water. All animals were divided into three groups, ten rats in each: Group 1 (10 rats) were left to heal the wounds without any assistance, reference Group 2 (10 rats) where the wounds were treated with Levomecol ointment, and experimental Group 3 (10 rats) where burn wounds were covered with films carrying immunomodulatory aminophthalhydrazide. Rats of the experimental group demonstrated a definitely earlier epithelialization start and earlier healing completion, as compared to the reference group: those treated with pectin films, on the 5th day of treatment, demonstrated a definite reduction of the burn wound area, becoming twice as less than that seen with the rats of the reference group (this holds true for both burn degrees). This dynamics was maintained until the animals were completely healed (30 days).