ENDOTHELIAL DYSFUNCTION AND PROGNOSTIC VALUE IN ITS CRITICAL STATE AS A RESULT OF ROAD TRAFFIC INJURIES
Objective: To identify prognostic role of endothelial dysfunction in traumatic disease, as an example of combined cranial and skeletal injuries, including received while intoxicated. Under the supervision of the 64 victims were males aged 23–58 years, with combined craniocerebral and skeletal injuries severe and moderate severity, obtained as a result of traffic accidents, in the acute period of traumatic disease, of whom 26 people. (40, 6%) were in a state of alcoholic intoxication. The control group consisted of 30 people. Healthy volunteers of similar age group. Measured NO, endothelin-1, von Willebrand factor in blood serum. All these parameters were significantly (p <0,05) altered in injured patients, 1.5-1.8 times. The changes were more pronounced (p <0,05) in people injured in a drunken state. It is shown that levels of NO, endothelin-1, von Willebrand factor in blood serum may be of prognostic value. Must take into account the fact that alcohol intoxication increases the manifestation of endothelial dysfunction.