DIFFERENCES IN THYROID AND DIABETIC SYNDROMES IN MEN AND WOMEN WITH COMBINED TYPE 2 DIABETES MELLITUS AND HYPOTHYROISIS
The aim of the work was to analyze the differences between diabetic and thyroid syndromes in men and women with a combined course of type 2 diabetes mellitus (type 2 DM) with hypothyroidism. The study included 98 patients with type 2 DM with hypothyroidism, of which 41 (41.8%) were males and 57 (58.2%) were females. The average duration of diabetic manifestations in men was significantly longer and amounted to 5.8±0.09 versus 4.5±0.12 years in women (p<0.05). The duration of thyroid syndrome, on the contrary, in women was statistically significantly longer (p<0.05), which in men was 10.7±0.04 versus 6.3±0.02 years. Inclusion criteria for the study were: type 2 DM of moderate severity in the stage of sub-/compensation without insulin, clinical and/or laboratory manifestations of hypothyroidism. The control group consisted of 11 healthy men and 14 women of the same age. Patients and healthy people of the same sex did not statistically differ in age (p>0.05). The American Diabetes Association (ADA) criteria (2013) were used to diagnose diabetes. The study of thyroid-stimulating hormone and thyroid hormones was carried out by the traditional radioimmune method. Statistical processing of the results was carried out using the software package for statistical analysis “Statistica 6.0”. The course of diabetic-thyroid pathology in representatives of different sexes has significant differences. Thus, in women, the duration of hypothyroidism was twice as long as in the male group and was clinically manifested by the predominance of thirst, excessive fatigue, facial edematous syndrome, octipation, depressive disorders, feeling of chilliness and hypothermia, unmotivated progressive increase in body weight, various cardiac symptoms. In men, the course of endocrinopathy was characterized by a significantly older age of the debut of such a comorbidity, the simultaneous debut of diabetic and thyroid syndromes, the dominance of a-/asymptomatic syntropia, the prevalence of symptoms of nicturia/polyuria, and memory loss.