EFFECT OF LIPID PROFILE ON VARIOUS FORMS OF HYPOTHYROIDISM
Objective. In the modern world, the number of patients with latent and overt hypothyroidism is constantly increasing. The presence of this disease among women is 19 per 1000 people. A link has been established between an increase in the level of thyroid-stimulating hormone (TSH) and atherogenic dyslipidemia and the progression of heart disease. The aim of our study was to determine the relationship between left ventricular diastolic function, thyroid-stimulating hormone and lipid spectrum in postmenopausal women with various forms of hypothyroidism. Methods. The present study was performed at the Department of Hospital Therapy of Smolensk state medical university in the period of 2016-2018. The study involved 70 women with various forms of compensation of hypothyroidism and diastolic dysfunction of the left ventricle. All women were divided into 3 groups: the control group consisting of 28 people, the first group - 35 patients with subclinical hypothyroidism confirmed by laboratory; the second group included 35 women with compensated hypothyroidism. Results. In the course of our study, the following results were obtained: the presence of an increase in the waist/hip ratio in women of the first and second groups, an increased body mass index indicating a pathological deposition of fat in the abdominal area, especially in patients of the second group, despite the fact that the group with subclinical hypothyroidism showed an increased level of thyroid-stimulating hormone compared to the group with compensated hypothyroidism. There were no significant differences in left ventricular diastolic function in the groups of study. Conclusion. The presented study, conducted on an outpatient basis, revealed interrelations of thyroid-stimulating hormone against the background of subclinical and compensated hypothyroidism with lipid profile and diastolic function, which indicated the need for prescribing drugs that affect the metabolic syndrome and reduce low-density cholesterol.