METHODOLOGICAL ASPECTS OF CREATING SPERMICIDES
The problem of preventing unplanned pregnancy have always been an urgent problem of various specialists. The oral hormonal contraceptives have a large number of contraindications. A significant factor limiting their use is that these drugs are unable to protect against sexually transmitted infections. Due to the widespread prevalence of genital infections, it is important to use local contraceptives that can combine spermicidal, antibacterial, antiviral or fungicidal effects, and can not only protect women from unwanted pregnancies, but also be a means of preventing sexually transmitted diseases. To systematize research, carried out in this direction, it is necessary to build an algorithm for the search for medicinal substances with spermicidal activity, which in parallel would have an antimicrobial effect. There is no methodological concept for the search for spermicidal substances among antimicrobial agents. An algorithm was developed to search for modern competitive local contraceptive drugs with combined activity, consisting of successively performed and interconnected stages: information search, research and standardization-pharmacological aspect. According to the established criteria, we searched for substances with a potential spermicidal effect. At the third stage of research of the development of medicinal products - standardization-pharmacological - experiments are carried out to identify the specific pharmacological activity of the developed dosage forms at the preclinical level and regulatory documentation is developed for them. A methodological approach based on an algorithmic principle will allow for screening of substances with spermicidal activity among antimicrobial drugs.