Prevalence of renal lesions in patients with type 1 and 2 diabetes mellitus in the Russian Federation
Aim. To study the prevalence of renal lesions in adult patients with type 1 and 2 diabetes mellitus in the Russian Federation. Materials and methods. A total of 7174 patients with DM1 and DM2 were examined in 20 regions of the Russian Federation for blood HbA1c creatinine, urea, and cholesterol levels, albumin excretion in a single urine sample, AP, and eye fundus condition. Albumin concentration from 20 to 200 mg/l was regarded as microalbuminuria (MAU) that above 200 mg/l as proteinuria (PU). The glomerular filtration rate (GFR) was calculated from Cockroft-Gault formula. Statistica-6 program was used for statistical treatment of the results of the study. They are represented as median, 25th and 75th percentile values (Me [25%;75%]). Differences between all parameters is considered significant at p<0,05 level. Results. Pathologic albumin excretion was documented in 42,1 and 45,3% of the DM1 and DM2 patients. Its prevalence increased with age and DM duration as well as at poor AP and glycemic control. Stage 2 chronic renal disease developed in 16,5 and 23,7%, stage 3 in 4,2 and 6,3%, stage 4-5 in 0,9 and 0,2% of the DM1 and DM2 patients respectively. 15,0 and 41,2% of DM1 and DM2 patients with MAU needed additional examination to elucidate non-diabetic origin of CRD. 40% of the DM2 patients with impaired GFR and poor glycemic control had to be transferred to insulin therapy.