Сitoprotection of endometrium in women with syndrome of loss of pregnancy of early terms by infectionally-inflammatory genesis: lectin-histochemical research
Aim of this reaserch is to give structural characteristic of mucoprotective apparatus of endometrium at female which were suffering from the loss of pregnancy early term with infection-inflammation genesis. Lectinohistochemical research of aspiration biopsies of endometrium from 84 patients in age 18-35 years which were suffering from the loss of pregnancy early term with infection-inflammation genesis was perfomed. Control is biopsies of endometrium from 15 somatically and gynecologically healthy women of the reproductive age, at wich research and had established selective lectine markers of some components of mucociliary apparatus of normal endometrium. All females of basic group have structural change of endometrium, wich characteristic for chronic endometritis. At the loss of pregnancy associated with chronic endometritis are noted increase level of connecting fucomucins and decrease level of sialic acid (depression of bactericidal property of uterine mucus). This can be promote stagnation of mucus in cavity of uteri, persistence of microorganisms, cause development of inflammatory, dystrophy and disregeneratory processes in endometrium, and also have significance in formation local immunopathologic reaction, wich complicate process of implantation of fetal ovum in endometrium.