INFLUENCE OF STROMAL-VASCULAR FRACTION CELLS ON REPARATIVE REGENERATION OF INDUCED ACHILLES TENDON INJURY
The purpose of the research is to provide a morphological justification of the effectiveness of cell products in Achilles tendon rupture. Autologous drugs have the highest biological safety among cellular drugs. Out of these, stromal-vascular cells and multipotent mesenchymal stem cells that have the ability to support themselves, differentiate into different cell types, and mobilize the reparative process in tissues have been positively recommended for clinical practice. Almost there’s no information about the dynamic morphological process control and reparations in their application. The impact of stromal-vascular fraction of rat adipose tissue on the regenerative process in the healing of the defect, which is expressed in reducing the risk of recurrence, peaceful architectonics fibers shaped dense connective tissue and activate the formation and maturation of granulation tissue have been evaluated. Based on the data on the positive effect of the studied cell product on the regeneration of the Achilles tendon, scientifically grounded its feasibility and use in veterinary medicine. The experimental model of the study is a fancy rat (n=20). The material for the study is the Achilles tendon. A set of methods including anatomical dissection, experimental modeling, and histological examination of Achilles tendon biopsies have been used. It was revealed that in experimental animals which were injected with this cell product, micromorphological transformations of connective tissue were detected, aimed affected the fibroarchitectonics and thickening of bundles of collagen fibers. The stimulating effect of the stromal-vascular fraction on the reparative process of the Achilles tendon defect is expressed in a greater degree of vascularization of the tissue and an increase in the number of fibroblasts in groups of experimental animals, while in animals of the control group, the regulating of fibers is disturbed, which contributes to the recurrences.