Behavioral phenotypic analysis of animals with a genetic model of Alzheimer''s disease
The main symptom of Alzheimer's disease is rapidly progressive dementia, which correlates with the formation of amyloid plaques and neurofibrillary proteins in tissue of the brain. This leads to the death of neurons, synoptic and cognitive dysfunction. The aim of the study was to study the development of social and cognitive impairments in the process of ontogenesis in animals with a genetic model of Alzheimer's disease. The object of the study is a genetic model of Alzheimer's disease is the B6SLJ-Tg line mice (APPSwFlLon, PSEN1 * M146L * L286V) 6799Vas, males aged 4 months. Control group - C57BL / 6 x SJL mice, males aged 4 months. Neurobehavioral testing included the following protocols: test «open field», elevated plus maze, light/dark transition test, a three-chamber social test, social recognition memory test in rodents, test «Fear conditioning». We identified features of behavioral in animals Tg 6799 line with the development of Alzheimer's disease. This increase the level of anxiety and lethargy, impaired social contacts and interactions, as well as spatial, social and associative learning and memory. Together, this indicates a disorder of emotional behavior, as well as long-term, social, spatial and emotional memory.