PATHOGENETIC ROLE OF SURFACTANT PROTEIN SP-D AT DISEASES LUNGS AND AIRWAYS
It was performed the analysis of published data on the role of surfactant protein SP-D in the immunopathogenesis of pulmonary diseases and respiratory tract. It considered the immunomodulation mechanisms of this protein and indicated that SP-D is considered as a factor in the programming of macrophages, multifunctional structure allows it to act as a dual-control factor to determine the phenotype of macrophages and the duality of the immune response, enabling the activation of pro-inflammatory immune response or inflammatory focus. Results to date data on the structure of the surfactant protein D and particularly its interactions alveolar macrophages in different lung diseases suggests that the protein may be used not only as a marker of lung injury but also as an agent to impact pathogenetic links of the inflammatory response that discloses new opportunity to address the fundamental problems of clinical medicine.