CYTOKINE PROFILE AND STATE OF RANKL/OPG SYSTEM IN PATIENTS WITH JUVENILE RHEUMATOID ARTHRITIS ON SANATORIUM STAGE OF REHABILITATION
The objective. To study cytokines status and indicators of RANKL/OPG in patients with juvenile rheumatoid arthritis at a sanatorium stage of rehabilitation. Patients and methods. At the sanatorium stage examined 40 patients with juvenile rheumatoid arthritis. The control group (CG) consisted of 15 healthy children. Quantitative determination of serum concentrations of the cytokine status indicators (TNF-α, IL-1, IL-6, IL-4, IL-10), and osteoprotegerin/RANKL was performed by the “two-step” linked immunosorbent assay (ELISA). The data were processed by mathematical statistics using certified computer packet processing «STATISTICA-6». Results. Revealed increasing concentrations of both proinflammatory and anti-inflammatory cytokines. Reducing anti-inflammatory potential associated with higher disease activity and the degree of functional impairment. Changes in the RANKL/OPG system showed decrease in the intensity of the remodeling of bone tissue, with a predominance of bone resorption. Conclusion. The violation of the processes of bone tissue remodeling, related to the immune changes being the basis of pathogenesis of disease, takes place at the juvenile rheumatoid arthritis. Changes in the system RANKL/OPG can assist violation of normal between by the processes of resorption and forming of bone and aggravated as far as growth of activity of inflammatory process. Disturbance of bone remodeling towards predominance of osteoresorption, caused by a change the ratio of cytokine mediators and inhibitors, which is a consequence of systemic inflammation.