Prediction and prevention of pre-eclampsia and fetal growth restriction at 11-14 weeks of gestation: analysis of 1001 cases
This was a retrospective analysis of 1001 women at 11 to 14 weeks’ gestation screened for pre-eclampsia (PE) and intrauterine growth restriction (IUGR) using specialized program, including data history, blood pressure, biochemical markers (PAPP-A, PLGF) and pulsatility index in uterine arteries. 55 high-risk women offered aspirin (150 mg at night). There are no cases of PE in low-risk 946 women and IUGR was in 3 (0,32 %) cases. In high-risk first subgroup only 3 (8,6 %) from 35 women offered aspirin 150 mg at night delivering babies with IUGR and there are no cases of PE in this subgroup. In high-risk second subgroup 9 (45%) from 20 women without aspirin delivering babies with IUGR and 2 (10 %) with PE. A strategy of first-trimester screening for PE and IUGR with prescription of aspirin to the high-risk group appears to be effective in re- ducing the prevalence of PE and IUGR.