THE PURPOSEFUL SEARCH OF DIURETIC AGENTS AMONG THE DERIVATIVES OF 2,7-DICHLORO-4-METHYLQUINO- LINE-6-SULFAMIDES
The purposeful synthesis of new sulfonylamides with the diuretical activity has been done using 4-methyl-7-chloro-1,2-dihydro-quinoline-6-sulfonylchloride in order to search biologically active substances. The screening of 2,7-dichloro-4-methylquinoline-6-sulfamide derivatives has been carried out and their inﬂuence on the excretory function of the kidneys in rats has been studied. The structure-activity relationship has been determined. The perspectiveness of futher synthesis for development of more effective and less toxic diuretic agents has been shown.