ГІГІЄНІЧНА ОЦІНКА ПЕРОРАЛЬНОГО ВПЛИВУ ІМІДАКЛОПРИДУ НА СТАТЕВОНЕЗРІЛИХ ТВАРИН З РІЗНОЮ ШВИДКІСТЮ АЦЕТИЛЮВАННЯ
Purpose of the study is to provide a hygienic evaluation of harmful effects of imidacloprid on the growing organism depending on the rate of acetylation. Materials and Methods. The experiment was modelled in 60 white immature male rats. Speed of acetylation was determined using the loading test with amidopyrine. The rats were administrated with imidacloprid intragastrically in a dose of 50 mg/kg during 14 days. Results and conclusions. Intoxication by imidacloprid at threshold dose causes delay of weight gain and increase of blood methemoglobin levels in immature animal. Level of methemoglobin in the blood is an important additional effect biomarker of imidacloprid for immature animals. Influence of pesticide causes also inhibition of the behavioural responses, increase of malondialdehyde and catalase and transaminases activity in blood in animals with the "rapid" type of acetylation and increase of the level of middle molecules in the blood plasma in the "slow" acetylators. Immature animals with the "rapid" type of acetylation are more susceptible to oral exposure of imidacloprid at threshold doses.