INFLUENCE OF PHARMACOLOGICAL AND HYPOXIC PRECONDITIONING ON ORGANISM TOLERANCE TO ACUTE HYPOXIA
Influence of pharmacological (amthizole 25 mg/kg) and hypoxic (moderate hypobaric hypoxia) preconditioning on lifespan of mice in different periods of adaptation to hypoxia were studied with acute hypercapnic and hypobaric hypoxia model. It was found that the combined preconditioning (amthizole+moderate hypoxia) led to higher increase of animal tolerance to acute hypoxia in the early (in 1 hour) and the late (in 48 hours) periods of preconditioning in comparison with preconditioning only by moderate hypoxia or amthizole.