NEW OPTIONS IN THE MANAGEMENT OF ACUTE PANCREATITIS
The targeted technology of long-term microdroplet irrigation of the pancreas that we have developed involves a direct effect on the organ tissue through the diffusion of drugs. We called this technique the “direct antisecretory method”. In the experiment, we tested microdroplet catheter methods for the drugs diffusion with a direct effect on the pancreas. To inhibit the secretory function of the pancreas, a method has been developed in which continuous local targeted delivery of drugs to the inflammatory focus is carried out. The aim of the study is to have a therapeutic effect on the inflammatory process by directed (targeted) supply of drugs to the focus of inflammation, blocking the secretion of the pancreas, which would contribute to the regression of the enzymatic cascade reaction. Using the proposed method, we achieved the «immersion» of the inflamed pancreas with the parapancreatic fiber involved in the process in the anti-enzymatic, decongestant, anti-inflammatory drug mixture. We achieved the delivery of drugs directly to the focus, which had a pronounced therapeutic effect on the interruption of the cascade-enzymatic inflammatory process. Due to the method, we have achieved the delivery of drugs directly to the area of inflammation and their prolonged action. The proposed method of prolonged local directed irrigation of the pancreas and surrounding tissues affects the inflammatory focus, prevents the development of infection of the primary aseptic process.