Mathematical modeling of new techniques for lung diffusion capacity examination
The article is devoted to mathematical modeling of carbon monoxide (CO) gas exchange process between alveolar air and the blood of pulmonary capillaries, on the base of which new methods of lung diffusion capacity investigation are proposed. In particular, model CO gas exchange for single breath diffusion capacity test was developed taking into account carboxyhemoglobin (COHb) generation and the noninvasive method of pulmonary hemodynamics investigation is proposed. Mathematical modeling of endogenous CO gas exchange was performed, taking into account cyclic lung ventilation, as a result of which an original method of alveolar-capillary membrane diffusion capacity was proposed. Alveolar volume measurement is proposed without using test gas mixtures. Algorithms of experimental determination of relationships between equilibrium CO concentration in exhaled air and COHb content in the blood, as well as total hemoglobin mass, were proposed.