Significance of comorbidity and systemic effects of chronic obstructive pulmonary disease in clinical practice
Chronic obstructive pulmonary disease is characterized by a certain comorbidity as well as a heterogeneous extrapulmonary manifestation. This article presents our research that shows a possible mechanisms of diabetes mellitus influence on pulmonary hypertension formation in chronic obstructive pulmonary disease and in turn its action on the sex hormones imbalance development, osteoporosis and morphological changes in respiratory muscles. It was found that the presence of diabetes mellitus intensifies a pulmonary hypertension growth in chronic obstructive pulmonary disease. We revealed an increase of hypogonadism against the background of estrogenization of patient’s body and dystrophic processes in the respiratory muscles as well as a severity of osteoporosis during chronic obstructive pulmonary disease progression.