BIOLOGICAL ACTIVITY OF SELENORGANIC COMPOUND 1,5-DI-(M-NITROPHENYL)-3-SELENAPENTADION-1,5 ANALYSIS
In work was studied the action of selenoorganic compound 1,5-di - (p-chlorphenil)-3-selenapentandion-1,5 on free radical oxidation, antioxidant status, functional state of tissues and metabolic processes at white not purebred mice. The given compound, on the one hand, had a small nephrotoxic effect (increased concentration of creatinine in blood plasma testifies about it), and, with another, compound possessed antioxidant activity in tissues of white mice, first of all, in a brain and lungs. The least antioxidant activity of the investigated compound is found in a liver and kidneys as xenobiotic detoxification occurs in a liver, and kidneys excrete the xenobiotics. Selenoorganic compound possessed high antioxidant activity that was expressed in considerable decrease in reactions the lipid peroxidation in a brain, lungs, erythrocytes and blood plasma.