THE POSSIBILITY OF ULTRASOUND DUPLEX SCANNING IN ASSESSING THE MOTION Of ATHEROSCLEROTIC PLAQUE
Due to high prevalence of cardio-pulmonary diseases there are a lot of difficulties in clinical practice with combined therapy with b1-adrenoblockers and b2-agonistS., which acting through ß-adrenergic receptors (ß-AR). Until recently, the methods of ß-AR research (PCR-RV., Western bloT., ELISA., cytofluometry, radioligand analysiS., level of secondary messengerS., cyclic AMP evaluation) have clear limitations for being used in a clinical practice (low reproducibility, non-availability, laboriousnesS., high cosT., high blood sampling). The newly developed modified radioligand method allows to estimatE., а new parameter - the binding activity of ß-AR with specific ligand. This modification allows to evaluate the dynamics of adrenoreceptor binding activity under the influence of medicines affecting ß-AR. The data obtained with this modified radioligand analysis will help to study the correlation of the clinical and receptor changes. It will provide information that will lead to a deeper understanding of the pathogenesis of cardiorespiratory pathology and will help to create optimized approaches for treat such patients.