POLYMORPHISMS OF THROMBOPHILIA GENES IN MYOPIA AS A MANIFESTATION OF CONNECTIVE TISSUE DYSPLASIA
The article presents data on the study of polymorphisms of 12 genes of the hemostasis system: blood coagulation factors, platelet receptor glycoproteins, genes regulating homocysteine metabolism in young people (Slavs) with connective tissue dysplasia with and without myopia. The presence of an association of myopia with allele A, genotypes A/A and G/A of the FII gene: 20210G/A (prothrombin), as well as with allele A, genotypes A/A and G/A of the FVII gene: 10976G/A (proconvertin). In the group of patients with DST and myopia, the frequency of occurrence of polymorphisms of integrin genes - ITGA2-a2: 807C/T, which controls platelet collagen receptors, was determined to be relatively higher than in the absence of it. A reliable association of myopia with the neutral AA genotype of the MTR gene: 2756A/G was shown.