THE ROLE OF T786C ALLELIC POLYMORPHISM OF ENDOTHELIAL NO-SYNTHASE GENE IN THE FORMATION OF PERIPHERAL VASCULAR TONE
168 male persons aged 18-22 years without complaints and heart problems were examined. It was investigated the association of this polymorphism with hemodynamics and vascular tone. We determined the basic parameters of hemodynamic and vascular tone. The study surveyed persons genotypes distribution of the studied polymorphism of NOS3 revealed that the ratio of normal homozygotes (TT), heterozygotes (TC) and pathological homozygotes (СС) - 42.3%, 46.4% and 11.3%, respectively. The most rare genotype is the СС, which according to several authors associated with the risk of arterial hypertension. It was found that allelic polymorphism T786C of endothelial NO-synthase gene not affect the mechanisms of systemic blood pressure, but participates in the formation of vascular tone. The higher peripheral vessels tone is a characteristic for persons with genotype CC. Persons with CC genotype characterized by more pronounced peripheral vasoconstriction, and they had a high index values of peripheral resistance after load (p<0.05) compared with other genotypes.