Study of glutathione and enzymes of its metabolism under the influence of enriched dairy products for prophylactic use in conditions of oxidative stress caused by excessive exercise
There was performed the study of the activity of the antioxidant system of glutathione under regular taking of enriched with micronutrients dairy products “Bifidin” and “Prolacta” in conditions of simulation of xcessive exercise loads. Target of research: white outbred male rats weighing 180-200 g (n=68). Research methods and equipment: information retrieval, biochemical, and statistical. In the subacute experiment there was established that in conditions of excessive exercise loads (CEEL) the body of the rat meets with significant oxidative stress, causing the suppression of the activity of glutathione system: the number of reduced glutathione and the activity of selenium-dependent glutathione-peroxidase decline. Regular taking of dairy products "Bifidin" and "Prolacta" in conditions of CEEL (active training process) allows effectively to neutralize lipid peroxidation processes and normalize indices of the system of glutathione. There is established an increase in the activity of glutathione-S-transferase in the homogenates of liver tissue in the simulation CEEL in combination with the use of product "Bifidin".