Photodynamic therapy with local application of the photosensitizer Photolon®. Experimental studies and fi rst clinical experience in patients with skin basal cell carcinoma
The newer drug form of the photosensitizer Photolon® (Fotolon®) for topical application was developed and introduced by RUE «Belmedpreparaty» (Republic of Belarus). In experimental studies in laboratory animals it was shown that local application of Photolon in a form of an ointment and subsequent irradiation with the laser light (665 nm) is eff ective in case of xenograft tumors in rats such as sarcoma M-1 and alveolar liver carcinoma PC-1. The objective of further studies was to evaluate the clinical efficacy of PDT with local administration of photosensitizer Photolon® in patients with basal-cell carcinoma of the skin.