RESULTS OF COMBINED TREATMENT OF PATIENTS WITH LOW-GRADE GLIOMAS WHO GRADE II
Objectives: Development of new alternative radiotherapy (RT) regimens in the treatment of supratentorial infiltrative low-grade gliomas WHO Grade II. Materials and methods: 53 patients with morphologically proven infiltrative low-grade cerebral gliomas WHO Grade II were included. Diffuse astrocytoma - 35 (66%), oligoastrocytoma - 7 (13%), oligodendroglioma - 11 (21%). Mean age - 39.5 years (standard deviation +/- 12), median age - 37.9 years. Outcome measures were assessed overall survival (OS). Results: In Cox hazard multivariate analysis, overall survive (OS) was predicted by fractionation radiotherapy regimen (standard versus hypofractionation) (p = 0,000) and type of radiotherapy (3D conformal versus 2D) (p = 0,023). Cox hazard multivariate analysis shows the statistical trend for the relationship between equivalent total fraction dose (LQ-model) and OS (p = 0,068). Risk groups of Association oncologists of Russia (AOR) (р = 0,947) and extent of surgical excision the tumor (р = 0,423) no effect on the outcome of LGG treatment. Conclusion: Standard radiation therapy (2 Gy per fraction once a day) improve OS. Hypofractionated radiotherapy regimen (3 Gy per fraction once a day) decrease OS. Conformal radiation therapy (3D-CRT, IMRT) and total fraction dose (≥ 56 Gy) improve OS.