Application of biological model for assessment of intestinal permeability of in vitro – a monolayer of epitelialny Caco-2 cells
Paper is devoted to the application of epithelial monolayer of human colon adenocarcinoma cells – Caco-2 for in vitro permeability evaluation of drugs. Main advantages of this biological model are described. General principles, approaches and methodology of Caco-2 permeability assay are defined. Correlation between human intestinal permeability in vitro and apparent permeability coefficient in vitro is indicated.