Influence of mesenchymal stem cells on the memory T-cells proliferation in patients with multiple sclerosis.
The perspective tendency in pathogenetic therapy of central nervous system's inflammatory-degenerative autoimmune diseases is based on mesenchymal stem cells (MSC) immunoregulatory properties. Using the intracellular fluorescent dye CFSE-method to monitor cell division we have shown that allogenic and autologous MSC inhibit in vitro mitogen- and my-elin-induced proliferation of pathogenetically important effector memory CD4 <sup>+</sup> and CD8 <sup>+</sup> Т-cells in multiple sclerosis patients. The mechanism of MSC-mediated immunosuppression can be caused by cell division arrest of early (М<sub>1</sub>-М<sub>2</sub>) gen­erations. The obtained results may be used for the individual approach for estimating MSC immunomodulatory properties and their further application of cell cultures in pathogenetic therapy of multiple sclerosis.