EVALUATION AND DINAMICS OF AIRWAY OBSTRUCTION IN PATIENTS WITH CHRONIC DESTRUCTIVE PULMONARY TUBERCULOSIS BEFORE AND AFTER TREATMENT
Aim. To study changes in bronchial patency and their correlation to initial manifestations of airway obstruction (AO) and to the rate of clinical and X-ray progression of tuberculosis (TB) in patients with chronic destructive pulmonary tuberculosis (CDP-TB). Materials and Methods. 117 patients with СDP-TB have been subjected to in-depth examination including specially designed questionnaire, physical examination, and spirometry along with bronchodilator test. Resistance to anti-tuberculosis drugs was determined by conventional bacteriological techniques, BACTEC MGIT 960 system, Hain test, and GeneXpert system.Results. Administered therapy improved bronchial patency only in 37,5% of patients with CDP-TB and AO. Such functional changes were more frequently observed in patients with initially minor or moderate obstructive disorders and correlated to the amelioration of clinical or X-ray course of TB. Conclusion. Improvement in bronchial patency can be considered as a therapeutic marker in patients with CDP-TB and AO, highlighting the need in the monitoring of respiratory function and timely prescription of bronchodilators.