SOLUBLE MOLECULES OF IMMUNOGLOBULINS SUPERFAMILY IN RHEUMATOID ARTHRITIS
Relationship of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) blood levels with features of course of rheumatoid arthritis was studied. 134 patients with rheumatoid arthritis (104 women, 30 men) at age from 20 to 66 years included in study. Duration of joint syndrome was 11.06±0.72 years. In majority of patients high degree of activity, III radiological stage, II and III functional classes of rheumatoid arthritis were diagnosed. Plasma concentration of adhesion molecules was studied by means of ELISA. Increase of levels of all adhesion molecules was observed (p<0.05). concentration of VCAM-1 and PECAM-1 in plasma was higher in seropositive patients or in presence of antibodies to cyclic citrullinated protein (p<0.05). In patients with late clinical stage levels of ICAM-1 and PECAM-1 were higher, than in early rheumatoid arthritis (р<0.05). High activity of disease was combined with raised plasma levels of ICAM-1 (р<0.05). Presense of systemic manifestations of disease and hematological disorders (hyperthrombocytosis) was accompanied by higher blood levels of all adhesion molecules (p<0.05). In values of SCORE scale of 5 and more points concentration of ICAM-1 and VCAM-1 in blood was higher (p<0.05), than in cases of low and moderated cardiovascular risk. Thus, the pathogenetic importance of immunoglobulins superfamily molecules in formation and progressing of rheumatoid arthritis is proved. Strengthening of adhesive function of endothelium is interfaced to increased cardiovascular risk. чем при раннем ревматоидном артрите (p<0,05). Высокая активность процесса сочеталась с ростом плазменных уровней ICAM-1. Наличие системных проявлений или гематологических отклонений (гипертромбоцитоза) сопровождалось более высоким содержанием всех молекул адгезии в крови (p<0,05). При значениях шкалы SCORE в 5 и более баллов концентрация ICAM-1 и VCAM-1 в крови была достоверно выше (p<0,05), чем в случаях низкого и умеренного кардиоваскулярного риска. Таким образом, доказана патогенетическая значимость молекул суперсемейства иммуноглобулинов в формировании и прогрессировании ревматоидного артрита. Усиление адгезивной функции эндотелия сопряжено с увеличенным сердечно-сосудистым риском.