Biologically Active Coordination Compounds of Germanium, Synthesis and Physico-chemical Properties
A promising area of modern coordination and supramolecular chemistry is the synthesis of biologically active compounds of germanium and the creation on their basis of effective drugs, biomaterials, enzyme modulators. The review is devoted to biologically active compounds of germanium (IV) and contributes to the solution of problems of synthesis, physicochemical analysis and prediction of the biological activity of complex germanium compounds with a wide spectrum of action. The features of the coordination and chemical properties of organic acids and amino acids in the processes of complexation with germanium dioxide and chloride are demonstrated. The literature data on the conditions of the complexation reaction, on the crystal and supramolecular structure of germanium (IV) complex compounds, geometry of germanium coordination polyhedra, types of hydrogen bonds, topology of coordination shells, pharmacological and biological properties of a number of compounds are considered.