THE INFLUENCE OF REHABILITATION AT SANATORIUMS AT THE SOUTHERN COAST OF THE CRIMEA UPON THE CONTENT OF LEVELS OF PRO-INFLAMMATORY CYTOKINE TNF-Α IN SYSTEMIC CIRCULATION AND IN SUPERNATANT OF BRONCHIAL EPITHELIAL CELL CULTURE IN PATIENTS WITH DUST LUNG PATHOLOGY
Analysis of changes of systemic and regional (endobronchial) levels of pro-inflammatory cytokine TNF-α was performed in patients with dust bronchitis and pneumoconiosis during their rehabilitation at specialized pulmonary sanatoriums at the Southern Coast of the Crimea based on clinical effectiveness of rehabilitation at sanatoriums. Systemic and regional (endobronchial) misbalance of cytokines with increase of pro-inflammatory cytokine TNF-α content were revealed in patients with dust lung pathology that can lead to progression of inflammation in loko morbi and lung fibrosis. The decrease of TNF-α content in serum and in supernatant of bronchial epithelial cell culture was determined under the influence of rehabilitation at the sanatorium in patients with dust bronchitis. Multiple reduction of TNF-α level in supernatant of bronchial epithelial cell culture was revealed in patients with pneumoconiosis on admission, that reflect disorders of protective cytokines activities, including anti-mycobacterial.