CHARACTER OF METABOLIC CHANGES IN EXPERIMENTAL ANIMALS EXPOSED TO ACUTE ALCOHOLIC INTOXICATION AND ITS CORRECTION WITH DRUGS
Alcoholism remains one of the most important medical and social problems currently. Research by many authors is devoted to the issues of chronic alcohol intoxication, accompanied by an imbalance of homeostasis, leading to diseases of the hepatobiliary system. The study of metabolic disorders in the liver in acute intoxication with high doses of ethanol and the assessment of the effectiveness of the timely use of hepatoprotective drugs is relevant. Acute intragastric administration of ethanol to laboratory animals was carried out, the corrective effect of oxymethyluracil was studied in comparison with Mexidol. Biochemical studies of the biomaterial of laboratory animals have been carried out. The analysis of the results obtained has established that when using "Mexidol" and oxymethyluracil after exposure to ethanol in high doses, a number of biochemical parameters that characterize the functional state of the liver in laboratory animals are normalized. At the same time, the difference in quality of changes in enzyme activity was revealed, due to adaptation processes and metabolic changes, which requires further studies of the pathogenetic mechanisms of acute exposure to ethanol.