ANTIARRHYTHMIC ACTIVITY OF SOME PSYCHOTROPIC DRUGS IN CENTRAL TACHYARRYTHMIA EXPERIMENTAL MODEL IN CATS
Preventive and arrestive antiarrhythmic activity of such psychotropic drugs as tiapride, sulpiride, diazepam, aphobazol, phenibut and ludiomil administered locally and intravenously have been studied in experimental model of central tachyarrythmia caused by electric and chemical stimulation of macromyelon ventrolateral sympathoactivating centre in cats. With the exception of ludiomil all the drugs studied proved to possess central antiarrhythmic activity. Tiapride, diazepam, phenibut and sulpiride revealed the highest sympatho-inhibitory activity. When administered locally aphobazol revealed low antiarrhythmic activity while in intravenous administrating the activity was very high. It confirms that aphobazol has a more explicit peripheral effect than that of central. Proarrhythmic activity of ludiomil might be attributed to its anticholinergic activity. Difference in drug effect rate depending on the local or intravenous administration might be caused by the fact that in intravenous administration peripheral effects of drugs are preserved while in their local administration they just influence the sympathoactivating neurons.