Early Prognosic Criteria of Placental Insufficiency Development in Pregnant Women with Iron Deficiency Anemia
The aim of the investigation was to detect early prognostic criteria of placental insufficiency development in pregnant women with iron deficiency anemia (IDA). Materials and methods. 143 pregnant women have been examined: 107 patients with IDA (main group) and 36 women with a physiological course of pregnancy (control group). The main group, in its turn, was divided into two subgroups: group 1 (n=28) included women with IDA found before 12 weeks of gestation, group 2 (n=79) comprised pregnant women with IDA diagnosed at 20-24 weeks. When laboratory signs of IDA were initially revealed, all patients of the main group were determined the degree of oxidative modification of blood serum proteins by the level of carbonyl derivatives based on the reaction of oxidized amino acid protein residues with 2,4-dinitrophenylhydrazine with formation of aldehyde- and ketondinitrophenylhydrazones (ADNPH, KDNPH). The level of the given proteins was investigated in the blood serum of the pregnant women in the control group at the same time. Results. It has been established, that changes in ADNPH and KDNPH levels in spontaneous oxidation is an early prognostic criterion of forming placental disorders in pregnant women with IDA, detected in I and II trimester of pregnancy. A mathematical model of placental insufficiency development in pregnant women with IDA has been worked out, which enables one to form a group of risk.