VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH PSORIASIS
In the current paper we present results on studying concentration of Vascular Endothelial Growth Factor (VEGF) in the blood sera of patients with psoriasis. Level of circulating VEGF in patients with psoriasis clearly tended to elevate in parallel with increasing severity as well as spreading of skin signs in case of severe clinical forms of cutaneous manifestations (exsudative, pustular lesions and erythroderma) as well as psoriatic joint disease. Increased level of VEGF was shown to depend on duration of the disease.Concomitant somatic diseases and age of patients proved to have no marked impact on the level of VEGF in the blood serum of patients with psoriasis.Level of circulating VEGF was found to change oppositely during therapeutic interventions.The results of the study let to uncover a pathogenetic role for VEGF in development of psoriatic process.