Study of chronic toxicity of potential anxiolytic Homeovox
Relevance. Assessment of chronic toxicity is a necessary stage of preclinical research a tablets Homeovox homeopathic. The aim of present research is study of chronic toxicity of a tablets Homeovox homeopathic. Methods. Homeovox was administered orally to males and females of rats and rabbits in doses of 100 and 1 000 mg / kg for three months. The appearance and the general state of animals were observed, the dynamics of body weight, feed and water consumption, behavioral reactions, rectal temperature, state of the cardiovascular system (electrocardiography, blood pressure measurement) were evaluated, hematological, biochemical and pathomorphological examinations were conducted to determine possible toxic effects and their reversibility, possible target organs and local irritant effect. Results. Parameters registered in the conducted studies did not get out the limits of the reference values for these species of animals. Homeovox did not cause any regular changes in the structure of the internal organs of rats and rabbits. Conclusion. Homeovox, administered to rats and rabbits for three months orally daily in doses of 100 and 1 000 mg / kg, did not demonstrate toxic effects and local irritant effect.