Dynamics of Synovitis Activity after Intraarticular Introduction of Xefocam to the Patients with Rheumatoid Arthritis (Data from Clinical and Instrumental Diagnostic Techniques)
Aim of the study. Evaluating the effectiveness of intraarticular administration of lornoxicam (Xefocam) in patients with rheumatoid arthritis (RA). Materials and methods. Xefocam was injected into the knee joints of 58 patients with RA at a dosе 8 mg 1 time a week for 3 weeks. In assessing the effect of the treatment severity of arthralgia, palpatory tenderness of joints were considered, the circumference of the knee at the top of the patella was measured. Before and after treatment ultrasonography (US) and thermography of the knee joints were carried out. Results. After intraarticular administration of Xefocam significant clinical improvement (decrease of arthralgias severity at least by 30 %) was observed in 44 patients. In the remaining patients the dynamics of pain was less significant. In the whole group there was a significant decrease in the severity of arthralgia, palpatory tenderness and circumference of the joints. According to the US a significant decrease in synovial membrane thickness and amount of exudates was noted. Conclusion. In the absence of clear indications for the local intraarticular injection of steroid therapy Xefocam can be used successfully to suppress moderate inflammatory changes in the joints of RA patients.