Synthesis and properties of Fe <sub>3</sub>O <sub>4</sub>/hydroxyapatite/pamidronic acid/diethylenetriaminepentaacetic acid/Gd <sup>3+</sup> nanocomposites
The novel Gd- containing magnetically sensitive nanocomposites were synthesized using the single- domain magnetite (Fe <sub>3</sub>O <sub>4</sub>), hydroxyapatite (HA), pamidronic acid (PA), diethylenetriaminepentaacetic acid (DTPA), gadolinium. We attached constituents sequentially to the surface of the compound that was synthesized in the previous reaction. Finally we synthesized nanocomposite Fe <sub>3</sub>O <sub>4</sub>/hydroxyapatite (HA)/ pamidronic acid (PA)/diethylenetriaminepentaacetic acid (DTPA)/gadolinium (Gd). Сomposition and structure of the nanocomposites were studied by FTIR spectroscopy, XRD and NMR. The synthesized nanocomposites can be used in medicine and biology, particularly in neutron capture therapy. They can serve as a multifunctional radio therapeutic drugs and diagnostic tools for targeted delivery, accumulation and retention of an external magnetic field.