THE INFLUENCE OF COVID-19 ON THE DEVELOPMENT OF NERVOUS SYSTEM PATHOLOGY
In spite of the importance and urgency of the new coronavirus infection problem, there are not enough reliable data on the peculiarities of COVID-19 and human body interaction, which underlines the expediency of new research in this area. In this literature review the issues of indirect and direct effect of SARS-CoV-2 on central and peripheral nervous system and the most widespread theories explaining the mechanisms of neuroinvasion of the virus are reviewed. The structure of neurological disorders is presented, the neurological symptoms typical for the prodromal and acute period of infection are reviewed, and the peculiarities of the development of early complications, such as headaches, in patients with COVID-19 are described, complete or partial disorder of olfactory and gustatory sensitivity, seizures, epileptic seizures, Bell's palsy, ischemic and hemorrhagic strokes, cerebral venous thrombosis, encephalopathies, encephalitis and meningitis. Interrelation of COVID-19 infection with the development of delayed effects of demyelinating and neurodegenerative character, namely multiple sclerosis, Guillain-Barré and Miller-Fisher syndromes, Alzheimer's and Parkinson's diseases was also proposed and argued. Psychoneurological disorders as well as a variety of somatic symptoms associated with SARS-CoV-2 infection have been identified.