The role of P-selectin glycoprotein ligand in leukocyte migration to the derma in cutaneous vasculitis
The expression of molecules, involved in inflammation process during leukocyte migration to the derma in dermal vasculitis, was studied. Histological preparations from patients were studied by the immunohistochemical method with identification of the markers. The derma contained a significantly higher level ofpositively stained cells expressing CD162 - P-selectin glycoprotein ligand, while the level of expression of another molecule, mediating cell-cell adhesion and diapedesis, CD99, in fact did not change. The level of cell proliferation marker increased in the endothelial cells, this indicating activation of dermal neoangiogenesis. These changes indicated that the development of inflammatory process in the skin in vasculitis was associated with a selective increase of the expression of adhesive molecules mediating leukocyte migration to the derma, which fact could be used for selecting new therapeutic approaches.