Comparative characteristics of pharmacodynamic effects of Phozinopril and Lizinopril in patients with arterial hypertension
The aim of the present work was to compare hypotensive activity of Phozinopril and Lyzinopril, their effects at morphofunctional heart parameters, at indexes of life quality in patients with arterial hypertension of the 1st and -2nd degrees. An open randomized comparative study of Phozinopril and Lyzinopril pharmacodynamic effects has been performed. For this study two parallel groups of patients were recruited. In these groups researchers compared and evaluated dynamics of arterial pressure, structural-functional cardiac parameters, indexes of life quality. The results obtained have shown that the course therapy with Phozicard and Lizinoton in patients with arterial hypertension has led to reliable decrease in arterial pressure. Target levels of arterial pressure were higher (p<0,05) in patients who took Phozicard. Dynamics in indexes of systolic and diastolic functions of the left ventricle, its structural parameters as well as some indexes of life quality had positive character and were comparable for both studied groups.. Phozicard and Lizinoton were well-tolerated by patients and were safe.