Biological effects of drug eprimek
During the research it was found that in the 7fold intramuscular administration to white rats at therapeutic doses, no adverse symptoms of poisoning rats was found. In the group of animals which eprimek administered at a dose of 3 times greater than the actual (600 ug / kg) at the end of the experiment was found to decrease body weight and muscular strength animals, increasing CPR and rectal temperature. Skin-resorptive effects of the drug eprimek missing. In the context of a 5-fold eprimeka application to the skin of animal deaths, changes of functional parameters, as well as skin irritation is not revealed. Eprimek preparation has no irritating and allergy effect on rabbits.