PATHOMORPHOLOGICAL CHANGES IN VITAL ORGANS IN PANCREONECROSIS
Objective. The aim of the paper is to study pathomorphological changes in vital organs in deceased patients, depending on the timeliness of medical care and the state of the pancreas, namely, aseptic (fat and hemorrhagic) and septic pancreatic necrosis. Materials and Methods. The authors studied pathomorphological changes in vital organs of 55 patients who died of pancreatic necrosis, who had/had not undergone inpatient treatment for it. Pathoanatomical studies were conducted in Ulyanovsk Regional Bureau of Forensic Medical Examinations (2010-2017). Results. Brain edema was noted only in patients with hemorrhagic pancreatic necrosis (7 cases). It proves that various forms of pancreatic necrosis have different destructive effects on the brain. The authors observed that this indicator was higher in the patients, who had not undergone any hospital treatment. This fact proves that the absence of intensive therapy contributes to the development of pancreatic necrosis. Conclusion. Hemorrhagic pancreatic necrosis is the main cause of death in the compared study groups. The pattern of pathomorphological changes in vital organs depends on the form of pancreatic necrosis. Pathomorphological changes accompanied by necrobiosis are revealed in the vital organs in all forms of the disease; this fact should be taken into account when examining and treating patients. Cerebral edema often contributed to the development of the medulla oblongata in patients with hemorrhagic pancreatic necrosis with and without any hospital treatment. However, this complication prevailed in the group of deceased persons who had not received any hospital treatment. This fact indicates the severity of pancreas destruction factors on the brain and proves that patients without intensive care therapy demonstrated a more unfavorable body state. In addition, pathomorphological changes in the myocardium were often regarded as myocarditis with elements of necrobiosis in patients with septic pancreatic necrosis who underwent hospital treatment.