Estimation of the liver functional condition after a single application of the drug Tsiprovet-pulmo
Tsiprovet-Pulmo is an antibiotic in a powder form. One gram of the drug contains 100 mg of ciprofloxacin and 450 mg of tiamulin hydrogen fumarate. The aim of the research was to study the functional state of the liver after a single dose of the drug T siprovet-Pulmo. The experiment was conducted on 90 white nonlinear mice weighing 18-20 g. The animals were divided into 9 groups of 10 mice each, Six groups were experimental, three groups were control. The mice of three experimental groups were injected with Tsiprovet-Pulmo at a dose of 5900 mg/kg (LD<sub>16</sub>), the remaining mice of three experimental groups were injected with drug at a dose of 8500 mg/kg (LD<sub>50</sub>). The antibiotic was introduced in the form of a solution of 1 ml. The control groups mice were orally administered with the saline solution at a dose of 1 ml per head. After 1, 3 and 6 hours after the oral drug administration the animals were intraperitoneally injected with hexenal in a dose of 60 mg/ kg. With the introduction of Tsiprovet-pulmo to the experimental animals in a dose of 5900 mg/kg (LD<sub>16</sub>) the duration of a hexenal sleep in an hour was 31,9 ± 4,2 min. When the hexenal applying through 3 hours after an administration of the antibiotic a hexenal sleep duration was 30.3 ± 3.9 min, and after 6 hours - 32.6 ± 4.2 min. When the dose increasing of Tsiprovet-Pulmo until 8500 mg/kg (LD<sub>50</sub>) in an hour a hexenal sleep lasted 32.7±4.3 min. With the introduction of hexenal 3 hours later the duration of a hexenal sleep was increased and amounted to 39,7±4,1 min, and 6 hours later the duration was 30,1±4,2 min. Thus, the drug Tsiprovet-pulmo at the doses close to the LD50 caused a short depression of a liver function, which was restored after 6 hours, and the dose of Tsiprovet-pulmo close to the LD<sub>16</sub> didn’t cause the functional changes in the liver activity.