WATER IS THE STRUCTURAL MATRIX OF LIFE
Objective. To summarize the results of research of water structural fractions in the animal and human blood at extreme exposures and pathological conditions carried out by the staff of the SSMU. Methods.This paper represents the results of scientific papers and theses analysis on this problem, written by the author and staff of the SSMU over the past 30 years. Results.The dependence of changes in the biopolymers degree of hydration in the blood of animals during their adaptation to external factorsis established by experiment. In the development of stress-response to the external environment during the period of urgent adaptation, the biopolymers degree of hydration increases in the resistance stage and decreases in the stage of exhaustion, it is fixed at the higher level than normal as a result of long-term adaptation and decreases in the development of disadaptation. In this connection, the conceptions of the structural basis of the body's adaptation are expanding. Adaptive stabilization of tissue structures consists not only in quantitative changes, in particular in the accumulation of stress-proteins, but also in the spatial change of the most important biopolymers, which corresponds to the greatest degree of their hydration. The formation of the structured hydrate shell of biopolymers and subcellular structures is a universal adaptive mechanism. Conclusions. Disturbance of the internal medium of the body, which occurs during extreme influences on the body and diseases, causes the change of the water structure in the blood as in an integrating medium. The ratio of the amount of associated and free water in the human blood is a non-specific indicator of internal medium state of the body, which doesn’t change the subject to the sex within acme, which allows referring it to the number of the basic health parameters. This molecular level criterion shows effectiveness of the treatment and the degree of patients’rehabilitation. There is a correlation between water structure indicators and results of general clinical, biochemical and functional research. This confirms the fact that the structural formations of water are the matrix for the development of fundamental processes in the human body.