THE EXPERIMENTAL MODEL OF STOMACH CANCER AS A DRIVER OF EMBRIOTYPY IN FETAL PERIOD OF RAT DEVELOPMENT
An experimental model of stomach cancer was adapted to study the pregnancy of breadless white laboratory rats, the development of their fetuses and the course of neonatal period using histological methods and embryological analysis. The following patterns were established: suppression of fertility in females, decrease in reproductive characteristics, fetal growth retardation syndrome. Particularly, there is shown insufficiency of structural conditions that support functional activity of internal organs in postnatal period. Examples include saccular stage of lung development, epithelial plug in the gut tube, myelopoiesis in the liver, metanephric blastema in the kidneys. Fetal embryotypy is suggested as a mophogenetic mechanism with pathognomonic features influenced by experimental stomach cancer.