Microbial translocation and systemic inflammatory response in HIV-infection
The purpose of the research was detection of markers of systemic inflammatory response syndrome together with levels of markers of gram-negative endotoxinemia in HIV-patients for evaluation of role of endotoxin in immune system hyperactivation and progression of disease. Material and methods. Evaluation of levels of endotoxin, sCD14, interleu-kin 1(3, TNF-a and C-reactive protein was done in 232 HIV-positive patients. LAL-test, ELISA and biochemical tests were used. Results. The statistically significant increase of levels of all markers of systemic inflammatory response which were investigated was detected in the group of HIV-positive patients, comparing to group of healthy individuals. Direct correlation of sCD14 level with most of markers of systemic inflammatory response was found. Increased level of sCD14 was associated with more prominent clinical and laboratory signs of immunosupression. Conclusion. These results confirm a role of endotoxin which is a marker of microbial translocation and highly active biological substance in pathogenesis of immune system hyperactivation and progression of HIV-infection.