THE ROLE OF SIGNALING MOLECULES IN PATHOGENESIS OF GASTROINTESTINAL TRACT DISEASES: OPTIMIZATION OF DIAGNOSTICS AND TARGET THERAPY
The review is devoted to the role of some signaling molecules produced by neuroendocrine and immune cells of the gastrointestinal tract (GIT) in the pathogenesis of the diseases of the digestive system. Special attention is paid to the key signaling molecules that provide local interactions between neuroimmunoendocrine cells and are considered as potential biomarkers. The determination of expression of such potential biomarkers should permit to optimize the diagnosis and choice of effective target therapy of specific gastrointestinal diseases.