POLIMORBIDITY FORMATION WITH THE HELP OF AN OXIDATIVE MISBALANCE AT A SOMATIC PATHOLOGY HAVING NO GENERAL PHISIOPATHOLOGY MECHANISMS OF PROGRESS AND THEIR MOLECULAR MARKERS
The aim of the research is to study formation of polimorbidity with the help of an oxidative misbalance at a somatic pathology that does not have physiopathology mechanisms of progress and their molecular markers. For this purpose we have measured a level of MDA (maalondialdehide) and SH-groups(a sulfhydryl group) and their correlation in a blood serum among the middle-aged and the elderly with the help of an enzyme method. We have noticed that elderly patients having no cardiovascular pathology have a more distinct low levels of antioxidative defense markers маркеров (according to the marker of a level of SH-groups in a blood serum by 8.9% on the average) and a high level of MDA in comparison with middle-aged patients (by 18.1% on the average). Besides, the accompanying regulated risk factors of a cardiovascular pathology lead to an oxidative status deterioration. The iron-deficient anaemia of the elderly adds to a decrease in antioxidative defense markers and an activation of prooxidation processes at a higher rate than among the middle-aged. As a result there is a decrease in a SH/MDA coefficient by 1.4 times. A combination of the ischemic heart trouble and the iron-deficient anaemia has the strongest prooxidation effect in comparison with healthy elderly people and among the patients with a monopathology, and is accompanied by a decrease in a SH/МDА coefficient by 1.2 times.