EVOLUTION OF DEFINITIONS AND SEPSIS DIAGNOSTICS AND SYSTEMIC INFLAMMATORY RESPONSE REACTION
The progress of diagnostic capabilities leads to the dynamism of the concept of «sepsis». But, to this day, the need to distinguish between the manifestations of a common inﬂ ammatory reaction and sepsis actually has not lost its relevance. The problem is particularly acute in surgery, because there is no single understanding of the process, but there is the broadest pluralism of its definition. The «gold standard» for the deﬁ nition of sepsis is still missing. The article presents the chronology and basic approaches to the determination of sepsis and its differentiation with the syndrome of a systemic inﬂ ammatory response. The basic foreign and native systems of signs and their evolution in the context of practical application are considered. The role of bacteriological research is shown, as well as the real possibilities of assessing a systemic inﬂ ammatory response using leukocyte indices. The possibilities of using the level and dynamics of blood procalcitonin and presepsin as a factor in the objectiﬁ cation of sepsis and its course are presented. An integrated approach to the diagnosis of sepsis is justiﬁ ed taking into account the individual characteristics, diagnostic capabilities and economic factors