THE ANXIOLYTIC EFFECT OF THE NEUROPEPTIDE CYCLOPROLYLGLYCINE IS MEDIATED BY AMPA AND TrkB RECEPTORS
Previously we have shown that the neuropeptide cycloprolylglycine (CPG) is an endogenous positive modulator of AMPA receptors and we have suggested that the pharmacological effects of CPG are associated with brain derived neurotrophic factor. In this paper we have first demonstrated that DNQX, the ihibitor of AMPA-receptors, and K252A, the ihibitor of Trk-receptors, prevented the anxiolytic effect of CPG, which confirms the formulated hypothesis.