Role of Growth Factors in the Pathogenesis of Pubertal Uterine Bleeding
To estimate a role of disorder of systemic growth factors production in pathogenesis of pubertal uterine bleeding, we have researched the hormonal status, and also have defined IGF-1, IGF-1BP, VEGF, EGF in two groups of patients - with uterine bleedings (I group) and healthy girls (control group). Activation of hypothalamo-pituitary-adrenal axis, high serum fIGF-1, endometrium hyperplasia (according to ultrasound) and a decreasing of VEGF at patients with uterine bleeding were revealed. High level of free IGF-1 and low serum VEGF can testify about a systemic disregulation processes of cyclic angiogenesis that leads to the folliculogenesis disorder in ovaries and activation of proliferative processes in endometrium.