Expediency of melatonin usage in patients with chronic gastric erosions from the position of the functional morphology disorders in enterochromaffin cells of the diffuse endocrine system
At present, it has been proved that the disorder in the intercellular mechanisms of enterochromaffin (EC) cells is caused by the functional morphology of the diffuse endocrine system’s (DES) disorder. Depending on the concentration level and EC-cells functional status, melatonin exhibits multi-phase action in the mechanism of chronic gastric erosions (CGE). Based on these facts we can suggest that the severity of the CGE clinical course is correlated with the severity of melatonin production disorder. The results of morphometric study have showed that the decrease in cytoprotective properties and regenerative functions of the gastric mucosa (GM) is caused by EC-cell hyperplasia, which creates conditions for the inflammation development and CGE progression. Changes in DES functional morphology indicate the pathogenetic role of hormonal homeostasis local disorders in the formation of inflammatory and degenerative processes in CGE. It has been established that CGE development is accompanied by changes of EC-cells morphofunctional indices. When used in complex melatonin therapy, indicators of EC-cells functional morphology are restored to a much greater extent than with the standard therapy of H. pylori, which suggests the expedient use of melatonin medication in the complex treatment of CGE