Effect of ACE inhibitor and receptor antagonist of type 1 angiotensin II on hemodynamics and morpho-functional parameters of the heart in patients with heart failure on a background of coronary heart disease combined with type 2 diabetes
Aim. The article discusses the evaluation of the effect of 3-month therapy of angiotensin-converting enzyme fosinopril and angiotensin II receptor antagonists valsartan on the clinical manifestations of CHF, hemodynamics and morphofunctional parameters of the heart, taking into account the function of the right ventricle and systolic pressure in the pulmonary artery in patients with ischemic heart disease Postinfarction cardiosclerosis in combination with type 2 diabetes. Material and Methods. 69 patients with IHD PICS, complicated by CHF II-III FC in combination with type 2 diabetes, were under observation. Patients were randomized into 2 groups: the first group consisted of 35 people taking fosinopril with an average daily dose of 20 mg, the second group consisted of 34 people taking ARS II valsartan at an average daily dose of 80 mg. Initially and after 12 weeks of treatment, all patients underwent a clinical examination, including clinical assessment of CHF manifestations, office blood pressure measurement and ECHR. Results. The appointment of ACEI and ARA II, led to an improvement in the clinical state of patients and the expansion of the functional capabilities of the myocardium. Conclusion. It should be noted that, without any particular advantages, in the effect on heart remodeling processes, fosinopril administration had a more pronounced effect on the systolic function of the left ventricle, and the use of valsartan significantly improved the diastolic function of the left ventricle.