RELATIONSHIP BETWEEN THE ACTIVITY OF THE INSULIN RECEPTOR AND ATP BLOOD ON THE BACKGROUND OF CHILDREN DYSLIPIDEMIA IN DIABETES MELLITUS
In the study of the of the interplay between the state of the energy metabolism of insulin receptors on the background of dyslipidemia in patients with diabetes mellitus (DM) children. The following parameters were studied in 70 children with diabetes type I and II: lipid and lipoprotein spectral insulinsbinding active membrane cells and red blood cells, ATP levels, the activity of membrane-bound enzyme Na+, K+-ATPazy, the concentration of malondialdehyde and other indicators. Is a direct correlation between the activity of the insulin receptor function and levels of ATP. Of metabolic abnormalities in patients with type 1 diabetes depend on the duration of diabetes, the stage of compensation of carbohydrate metabolism and the presence of vascular complications has been a marked increase in the content of total cholesterol in patients over 5 years of disease or vascular complications. Patients with type 2 diabetes characterized by more open and diverse abnormalities in lipid metabolism. Elevated levels of total cholesterol and triacylglycerides in the serum was associated with decreased HDL cholesterol. At the heart of the metabolic deficiency in children with diabetes, there are dyslipidemia, structural – functional properties of membrane-receptor system cells, including a decrease in the level of ATP, inhibition of the activity of membrane-bound enzyme Na+, K+-ATPazy, a sharp decline insulinsbinding receptor activity and a decrease in consumption glucose by cells, which indicates a decrease in the sensitivity of cells to insulin. Patients with type 2 diabetes characterized by more open and diverse abnormalities in lipid metabolism.