Pharmacokinetics and clinical effects of 1% Meditin in horses
This paper studied the pharmacokinetic profile and effect on the body equine medetomidine. Determination of its concentration in the blood serum of horses by the method of high performance liquid chromatography with mass spectrometric detection using internal standard of detomidine allowed to reveal the pronounced individual variability of the substance. The maximum allowed concentration of medetomidine and the value of the average time of retention in the systemic circulation. Identified positive correlation of pharmacokinetic and clinical effects of the drug when administered intramuscularly to horses.