The Microcirculation System in Critical Conditions Caused by Abdominal Sepsis
<i>Objective: </i>to evaluate the microcirculation system in critical conditions caused by abdominal sepsis for a further differentiated approach to intensive care. <i>Subjects and methods. </i>Twenty-four patients with abdominal sepsis (mean age 42.9±0.9 years) were examined; a control group consisted of 35 apparently healthy individuals (mean age 40.1±2.1 years). Over 11 days, the microcirculatory bed was evaluated by cutaneous laser Doppler flowmetry by means of a ЛАКК-02 laser capillary blood flow analyzer made in the Russian Federation (LAZMA Research-and-Production Association), by using a basic light guide for percutaneous microcirculation studies. <i>Results. </i>Throughout the study, tissue blood perfusion remained in the patients with sepsis due to the higher effect of mainly active components of vascular tone regulation on the microvascular bed. In a poor outcome, there was a reduction in both active and passive regulatory effects on tissue perfusion chiefly due to local (myogenic) factors. <i>Conclusion. </i>The findings suggest that the patients with sepsis have microcirculatory regulation changes aimed at maintaining tissue perfusion. A follow-up of the microcirculation may be useful in choosing intensive care tactics and predicting disease outcome.