BIOMARKERS OF INFLAMMATION IN EARLY DIAGNOSTICS AND MONITORING OF COMPLICATIONS IN PATIENTS WITH OBSTRUCTIVE UROPATHIES
Changes in the levels of biologically active compounds (acute phase protein, C-reactive protein, ceruloplasmin, proinflammatory (IL-1-beta, 6, 8; TNFα) and contrainflammtory (IL-4,10) cytokines, intercellular adhesion molecules (sE-selectin)) were measured in different biologicalfluids (serum, urine) of patients with obstructive uropathies. Methods of solid-phase immunoenzyme analysis were used for the purpose using a Stat Fax analyser (Stat Fax, USA). The study demonstrated diagnostic value of non-invasive methods for the detection of IL-6, 8 in urine and highly sensitive serum CRP playing the key role in the initiation of inflammatory processes in urinary tract. Calculation of urinary inflammation index in children during chronic obstructive pyelonephritis allows to objectively estimate the phase of inflammation and the efficacy of its treatment.