FEATURES OF THE LIPIDE EXCHANGE AT SYSTEM THERAPY OF RETINOIDS
Inverse alterations in plasma levels of cholesterol is recognized side effect of systemic treatment with the synthetic retinoids isotretinoin. Moderate-dose isotretinoin (0,56 ± 0,07 mg/kg) increases level of cholesterol (15,6 %), low-density cholesterol and triglycerids (32 %) after 1 month therapy. There is a decrement in levels of low-density cholesterol and triglycerids till the end of the treatment.