THE ROLE OF RENOSCINTIGRAPHY IN PATIENTS WITH HEPATOCELLULAR CARCINOMA WHO UNDERWENT IMMUNOSUPPRESSIVE THERAPY AFTER LIVER TRANSPLANTATION
Purpose. To determine the diagnostic role of dynamic renoscintigraphy in a general complex of methods for examining patients with hepatocellular carcinoma (HCC) after liver transplantation applying immunosuppressive therapy. Materials and methods. Renoscintigraphy was performed in dynamic mode after intravenous administration of 99mTc-pentatech at a rate of 0,7-1,0 MBq/kg, followed by calculation of digital parameters reflecting the secretoryexcretory function of the kidneys. Outcomes. From 2013 to 2017, 168 patients with HCC who underwent liver transplantation were examined using renoscintigraphy. In the group of patients taking Ciclosporin, there was a significant decrease in parenchymal functional activity and secretory-excretory function of the kidneys (p <0.05), compared with the group of patients who used Tacrolimus in the postoperative period. After Tacrolimus therapy, a stable long-term function of the hepatic transplant was achieved, and no signs of chronic nephrotoxicity were detected. Conclusions. Renoscintigraphy is a sensitive method of dynamic monitoring of the evaluation of the effectiveness of postoperative treatment of patients with HCC and pathogenetic correction of immunosuppressive therapy.