SIDE EFFECTS AND OPTIMIZATION OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ACCORDING TO THE EXPERIENCE OF SAINT-PETERSBURG AIDS CENTER
The Russian Federation experienced an increase in the number of HIV cases at advanced stages in need of antiretroviral therapy (ART). The main objectives in choosing of an ART are to suppress virus replication, to control drug intolerance, to manage the problems of early and late toxicity, and to ensure easy administration. According to the experience of Saint-Petersburg AIDS Center, the rate of side effects is 11.7%. With account of drug type, the rates are as the following: NRTI - 45%, NNRTI - 21%, and PI - 19%. The most prevalent side effects are gastrointestinal effects, anemia, toxic dermatitis, and lipodystrophy. Of major importance for adherence to treatment are the prevention of side effects, the detection of potentially serious complications, and the use of antiretroviral drugs featuring the most favorable therapeutic effects.