Possibilities of modern antihypertensive therapy in the treatment of arterial hypertension in patients with chronic obstructive pulmonary disease
Based on the latest national and foreign literature data, the current state of the problem concerning arterial hypertension (AH) treatment in patients with chronic obstructive pulmonary disease (COPD) is presented. AH is the most common comorbid pathology in patients with COPD. Emphasis is placed on the importance of studying different types of blood pressure variability and evaluating its dynamics under the exposure of modern antihypertensive therapy. Excessive activity of the renin-angiotensin-aldosterone system in patients with AH and COPD confirms the need for specific therapeutic effect, given the positive effect of antihypertensive drugs (AHD) on this system. Angiotensin converting enzyme inhibitors, in particular, fosinopril, have such properties. This article shows the association between blood pressure variability and the severity of fosinopril pleiotropic effects, in particular its effect on endothelial function and pulmonary artery pressure, as well as the fosinopril predominance over other AHD in the treatment of AH in patients with COPD. The authors present the results of their own observations.