THE FEATURES OF HORMONAL PROFILE IN RATS OF THE SHR AND WISTAR-KYOTO
The aim of the work was to clarify the mechanism of adverse perinatal outcomes in chronic arterial hypertension in an experiment based on the study of the peculiarities of changes in systemic arterial pressure, progesterone and cortisol concentrations in the initial state, at the 2nd (11-12 day) and 3rd week (17-19 day) gestation in rats SHR and WKY. During the experiment, 38 SHR rats were used, 11 - WKY at the age of 9 weeks. At the first stage, changes in systemic blood pressure, concentrations of progesterone and cortisol in SHR and WKY rats in the initial state were studied, on the 2nd (11-12 day) and 3rd week (17-19 day) gestation, in the second - they observed perinatal outcomes and condition of newborn rats (weight, height, adaptation reactions). It was found that in the dynamics of gestation in SHR rats, there is a consistently high blood pressure, a decrease in the concentration of progesterone, and a high level of cortisol at 2 and 3 weeks of gestation. In WKY rats, there was a significant decrease in blood pressure by the 2nd week of gestation, a significant increase in the concentration of progesterone by the 2nd week of gestation, with a slight tendency to decrease towards the end of pregnancy and a consistently normal cortisol concentration in the dynamics of gestation. Gestation in SHR rats is unfavorable, there is a tendency to the development of delayed growth of the fetus, which indicates the presence of placental disorders. Childbirth often premature. SHR rats are born significantly less than in WKY rats, their weight and height are significantly smaller, and maladaptive reactions are noted. SHR rats should be considered the best option for an analog model of chronic arterial hypertension, including the study of aspects of gestational and other disorders in experimental conditions.