Which protein is required for Argonaute 2 recruitment to stress granules and P-bodies?
['we examined whether another Hsp90 inhibitor radicicol (RA) affected P-bodies and stress granules. Treatment with RA reduced the level of the Hsp90 client protein Argonaute 2 and the number of P-bodies. Although stress granules still assembled in RA-treated cells upon heat shock, they were smaller and more dispersed in the cytoplasm than those in untreated cells', 'Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules and P-bodies', 'Processing bodies (PBs) and stress granules (SGs) are the two main types of ribonucleoprotein complexes with which Argonautes are associated. Targeting of Argonautes to these structures seems to be regulated by different factors. In the present study, we show that heat-shock protein (Hsp) 90 activity is required for efficient targeting of hAgo2 to PBs and SGs', 'Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules and P-bodies.', 'Treatment with RA reduced the level of the Hsp90 client protein Argonaute 2 and the number of P-bodies.', 'Treatment with RA reduced the level of the Hsp90 client protein Argonaute 2 and the number of P-bodies. ', 'In the present study, we show that heat-shock protein (Hsp) 90 activity is required for efficient targeting of hAgo2 to PBs and SGs. ', 'To verify these observations, we examined whether another Hsp90 inhibitor radicicol (RA) affected P-bodies and stress granules. Treatment with RA reduced the level of the Hsp90 client protein Argonaute 2 and the number of P-bodies.', 'Treatment with RA reduced the level of the Hsp90 client protein Argonaute 2 and the number of P-bodies.']
['Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules and P-bodies.']
['Hsp90']