Which disease can be treated with Delamanid?
['Recently approved anti-Tb drugs (bedaquiline and delamanid) have the potential to induce arrhythmia and are recommended in patients with MDR-Tb when other alternatives fail.', 'Delamanid: a review of its use in patients with multidrug-resistant tuberculosis.', 'Delamanid (Deltyba(®)), a nitroimidazo-oxazole derivative, is a new anti-tuberculosis (TB) drug which exhibits potent in vitro and in vivo antitubercular activity against drug-susceptible and -resistant strains of Mycobacterium tuberculosis. ', 'In a robust phase\xa0II trial in adult patients with MDR-TB, oral delamanid 100\xa0mg twice daily for 2\xa0months plus an optimized background regimen improved sputum culture conversion rates to a significantly greater extent than placebo. ', 'In conclusion, delamanid is a useful addition to the treatment options currently available for patients with MDR-TB.', 'Delamanid when other anti-tuberculosis-treatment regimens failed due to resistance or tolerability.', 'This review covers the efficacy and safety of delamanid for MDR-TB.AREA COVERED: This paper reviews the pharmacological profile of delamanid and the results of clinical trials evaluating its efficacy for treating MDR-TB in combination with other anti-TB drugs. ', 'EXPERT OPINION: Delamanid showed potent activity against drug-susceptible and -resistant Mycobacterium tuberculosis in both in vitro and in vivo studies.', 'In addition, decreased mortality was observed in MDR-TB patients who received>6 months of delamanid treatment. ', 'Therefore, delamanid could be used as part of an appropriate combination regimen for pulmonary MDR-TB in adult patients when an effective treatment regimen cannot otherwise be composed for reasons of resistance or tolerability.', 'Delamanid for multidrug-resistant pulmonary tuberculosis.', 'BACKGROUND: Delamanid (OPC-67683), a nitro-dihydro-imidazooxazole derivative, is a new antituberculosis medication that inhibits mycolic acid synthesis and has shown potent in vitro and in vivo activity against drug-resistant strains of Mycobacterium tuberculosis.METHODS: In this randomized, placebo-controlled, multinational clinical trial, we assigned 481 patients (nearly all of whom were negative for the human immunodeficiency virus) with pulmonary multidrug-resistant tuberculosis to receive delamanid, at a dose of 100 mg twice daily (161 patients) or 200 mg twice daily (160 patients), or placebo (160 patients) for 2 months in combination with a background drug regimen developed according to World Health Organization guidelines. ', 'This finding suggests that delamanid could enhance treatment options for multidrug-resistant tuberculosis. ', 'Delamanid was not associated with clinically relevant drug-drug interactions, including with antiretroviral drugs and those commonly used in treating TB. Delamanid was generally well tolerated in patients with MDR-TB, with gastrointestinal adverse events and insomnia reported most commonly.', 'Linezolid may represent a valuable drug to treat cases of XDR-TB. Delamanid, bedaquiline, and PA-824 are new anti-TB agents in the development pipeline that have the potential to enhance the cure rate of XDR-TB.']
['Delamanid is used in patients with multidrug-resistant tuberculosis.']
['tuberculosis']