What is the effect of Allopurinol on asphyxia in neonates?
['Potential neuroprotective strategies targeting different pathways leading to neuronal cell death in response to hypoxic-ischemic insult have been investigated: hypothermia, erythropoietin, iminobiotin, deferioxamine, magnesium, allopurinol, xenon, melatonin and statins.', 'Allopurinol reduces the formation of free radicals, thereby potentially limiting the amount of hypoxia-reperfusion damage.', 'There were no differences in long-term outcome between the allopurinol-treated infants and controls. However, subgroup analysis of the moderately asphyxiated group showed significantly less severe adverse outcome in the allopurinol-treated infants compared with controls (25% vs 65%; RR 0.40, 95%CI 0.17 to 0.94).', 'The reported data may suggest a (neuro)protective effect of neonatal allopurinol treatment in moderately asphyxiated infants.', 'The asphyxiated newborns treated with allopurinol had better neurologic and neurodevelopmental outcome at 12 or more months of age.', 'In newborn infants, allopurinol is being tested as a free radical scavenger to prevent brain damage caused by reperfusion and oxygenation after perinatal hypoxia and ischemia (birth asphyxia).', 'Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia.', 'The analysis showed an unaltered (high) mortality and morbidity in the infants treated with allopurinol.', 'Allopurinol treatment started postnatally was too late to reduce the early reperfusion induced free radical surge.', 'One randomized trial of allopurinol showed short-term benefits but was too small to test death or disability.', 'No toxic side effects of ALLO were detected.', 'This study suggests a beneficial effect of ALLO treatment on free radical formation, CBV, and electrical brain activity, without toxic side effects.']
['Allopurinol was shown in a number of clinical trial to be safe and effective for treatment of neonatal asphyxia. Allopurinol  improves short-term and long-term clinical outcomes of neonatal asphyxia. Allopurinol should be administered as soon as possible. Postulated mechanism of allopurinol action in this setting is prevention of hypoxia-perfusion injury by reduction of free radical formation.']
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