What is the role of thyroid hormone receptor alpha1 in insulin secretion?
['loss of Thra protects mice from high-fat diet-induced hepatic steatosis and hepatic and peripheral insulin resistance.', 'liganded TR(alpha) plays a critical role in beta-cell replication and in expansion of the beta-cell mass during postnatal development. Thus, liganded TR(alpha) may be a target for therapeutic strategies that can induce the expansion and regeneration of beta-cells.', 'the TRalpha P398H mutation is associated with visceral adiposity and insulin resistance']
['Liganded TR(alpha) plays a critical role in beta-cell replication and in expansion of the beta-cell mass. the TRalpha P398H mutation which cannot bind T3, is associated with  insulin resistance. Loss of Thra protects mice from high-fat diet-induced hepatic and peripheral insulin resistance.']
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