What are the effects of BMAL1 deficiency?
['BMAL1 deficiency is associated with premature aging and reduced lifespan', 'BMAL1 deficiency leads to development of stress induced senescence in vivo.', ' Down-regulation of Bmal1 accelerates the development of tumours ', 'BMAL1 deficiency results in premature aging in mice', 'BMAL1 deficiency disrupts circadian oscillation in gene expression and reactive oxygen species homeostasis in the brain,', 'We demonstrate that attenuation of Bmal1 function resulted in down-regulation of genes in the canonical Wnt pathway, known to suppress adipogenesis. ']
['BMAL1 deficiency is associated with premature aging and reduced lifespan and BMAL1 deficiency leads to development of stress induced senescence in vivo. Down-regulation of Bmal1 also accelerates the development of tumours, adipogenesis.']
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