Which is the gene mutated in type 1 neurofibromatosis?
['Individuals with NF1 harbor 1 mutated NF1 allele', 'type 1 (NF1) is a hereditary disorder caused by mutations in the NF1 gene', 'The NF1 gene, mutated in NF1, is also commonly mutated in sporadic glioblastoma multiforme (GBM)', ' type 1 (NF1) is a common genetic disease caused by haploinsufficiency of the NF1 tumor-suppressor gene', 'Neurofibromatosis type 1 (NF1) is a common disorder of dysregulated tissue growth secondary to mutations in the tumor suppressor gene NF1', 'tumor suppressor protein neurofibromin, which is mutated in NF1', ' Neurofibromatosis type 1 is one of the most common autosomal dominant disorders, affecting about 1:3,500 individuals. NF1 exon 7 displays weakly defined exon-intron boundaries', 'Loss of heterozygosity (LOH) of NF1', 'Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder resulting in the growth of a variety of tumours, ', 'ten occur in both children and adults as sporadic events with no family history of the disease, but they are also among the clinical manifestations of a significant number of familial cancer syndromes, including familial retinoblastoma, neurofibromatosis 1 and 2, tuberous sclerosis, and Cowden, Turcot, Li-Fraumeni and nevoid basal cell carcinoma (Gorlin) syndromes. ', 'These genes include RB1, NF1, NF2, TSC1, TSC2, TP53, PTEN, APC, hMLH1, hPSM2, and PTCH', 'von Recklinghausen syndrome (NF-1) (OMIM 162200) carrying NF1 germline mutations', 'mutations of the NF1 gene have been reported in patients with neurofibromatosis type 1 (NF1)', 'NF1 gene mutation in a Japanese patient with neurofibromatosis type 1 ', 'Neurofibromatosis 1 gene (NF1 ) fulfills the criteria of a tumor suppressor gene and is deleted or mutated heterozygously in patients with NF1', 'type 1 (NF1) is one of the most common human genetic disorders and is associated with significant morbidity and mortality. The gene responsible for this disorder, NF1, encodes neurofibromin,', ' genes mutated in these two disorders encode tumor suppressor proteins, termed neurofibromin (NF1)', ' tumour-suppressor genes, Nf1 and Trp53. Humans with mutations in NF1 develop neurofibromatosis type I (NF1', 'type 1 (NF1) is an autosomal dominant genetic disorder affecting one in 3,500 individuals. The mutation rate in the NF1 gene is one of the highest known for human genes.', 'patients with neurofibromatosis type 1 (NF1) were screened for mutations in the NF1 gene.', 'It is caused by a wide spectrum of mutations affecting the NF1 gene. ', 'NF1) is a common familial tumour syndrome with multiple clinical features such as neurofibromas', 'This neoplastic lesion is a common feature of neurofibromatosis type 1 (NF1), one of the most common autosomal dominant disorders. The NF1 gene codes for a protein called "neurofibromin.', 'type 1 (NF1) and type 2 (NF2) are connected with genes localized on chromosomes 17 and 22, respectively. The genes that are inactivated in neurofibromatosis code for the proteins neurofibromine and merline', 'neurofibromatosis type 1 (NF1) gene, well recognized for its high frequency of spontaneous mutations.', 'An NF1 gene was identified as a gene whose loss of function causes an onset of human disorder, neurofibromatosis type I.', 'type 1 (NF1) is caused by deletions, insertions, translocations, and point mutations in the NF1 gene', 'type 1 (NF1) gene is a tumor suppressor gene, and the NF1 gene product, neurofibromin', 'ysine 1423 of neurofibromin (neurofibromatosis type I gene product [NF1]) plays a crucial role in the function of NF1.']
['NF1 gene, encoding neurofibromin 1']
['NF1']