List sclerostin interaction partners.
[' Several previously unidentified full-length sclerostin-interacting proteins such as alkaline phosphatase, carbonic anhydrase, gremlin-1, fetuin A, midkine, annexin A1 and A2, and collagen α1, which have established roles in bone formation or resorption processes, were bound to the sclerostin-MBP amylose resin but not to the MBP amylose resin. Other full-length sclerostin-interacting proteins such as casein kinase II and secreted frizzled related protein 4 that modulate Wnt signaling were identified. Several peptides derived from proteins such as Phex, asporin and follistatin that regulate bone metabolism also bound sclerostin. ', 'We identified an interaction between sclerostin and the carboxyl-terminal portion of the receptor tyrosine-protein kinase erbB-3.', 'Sclerostin, SOST, the gene affected in this disease, has been postulated to exert its activity by functioning as a BMP antagonist. However, recent evidence indicates that SOST is highly related to Wise, which can also modulate the Wnt pathway by binding to LRP5 and LRP6.', 'Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.', 'We show that recombinant sclerostin and noggin bound to each other with high affinity (K(D) = 2.92 nm).']
['alkaline phosphatase\ncarbonic anhydrase\ngremlin-1\nfetuin A\nmidkine\nannexin A1 \nannexin A2\ncollagen α1\ncasein kinase II \nsecreted frizzled related protein 4\nPhex\nasporin\nfollistatin\nerbB-3\nLRP5 \nnoggin']
['alkaline phosphatase', 'carbonic anhydrase', 'gremlin-1', 'fetuin A', 'midkine', 'annexin A1', 'annexin A2', 'collagen α1', 'casein kinase II', 'secreted frizzled related protein 4', 'Phex', 'asporin', 'follistatin', 'erbB-3', 'LRP5', 'noggin']