Can exosomes be detected in urine?
['Exosomes are nanovesicles secreted into the extracellular environment upon internal vesicle fusion with the plasma membrane. The molecular content of exosomes is a fingerprint of the releasing cell type and of its status. For this reason, and because they are released in easily accessible body fluids such as blood and urine, they represent a precious biomedical tool. ', 'Exosomes are vesicles that are released from the kidney into urine.', 'Quantification of human urinary exosomes by nanoparticle tracking analysis.', 'Urinary extracellular vesicles (uEVs) are released by cells throughout the nephron and contain biomolecules from their cells of origin.', 'Urinary exosomes have been proposed as potential diagnostic tools.', 'Urinary exosomes as a source of kidney dysfunction biomarker in renal transplantation', '. Here we sought to optimize the methodologies for the isolation and quantification of urinary exosomal microRNA as a prelude to biomarker discovery studies. ', 'Exosomes are small (30-150\u2009nm) vesicles containing unique RNA and protein cargo, secreted by all cell types in culture. They are also found in abundance in body fluids including blood, saliva, and urine. ', 'Urinary exosome-like vesicles (ELVs) are a heterogenous mixture (diameter 40-200\u2009nm) containing vesicles shed from all segments of the nephron including glomerular podocytes', 'Exosomes are cytoplasm containing vesicles released by many cells that can be found in several biological fluids including urine.', 'Proteomic analysis of urinary exosomes in cardiovascular and associated kidney diseases by two-dimensional electrophoresis and LC-MS/MS']
['Yes, urinary exosomes can be detected in urine.']
['yes']