Are thyroid hormone receptor alpha1 mutations  implicated in thyroid hormone resistance syndrome?
['Mutations in human TRα1 mediate RTH with features of hypothyroidism in particular tissues (e.g. skeleton, gastrointestinal tract), but are not associated with a markedly dysregulated pituitary-thyroid axis.', 'Clinical phenotype of a new type of thyroid hormone resistance caused by a mutation of the TRα1 receptor']
['thyroid hormone receptor alpha1 mutations are implicated in thyroid hormone resistance syndrome']
['yes']