What is the major adverse effect of adriamycin(doxorubicin)?
['It remains to be seen whether inhibition by adriamycin of these systems is related to the severe cardiotoxicity, the major adverse effect of the drug that limits its clinical usefulness.', 'Leukocytopenia was the major adverse effect among patients undergoing systemic THP administration', 'The major adverse effect was bone-marrow suppression;', 'The major adverse effect was bone marrow suppression;', 'Cardiotoxicity is a major adverse effect of the anthracycline antibiotics and can be acute or chronic;', 'chronic cardiotoxicity represents a serious adverse effect that may be lethal due to the development of irreversible, cumulative dose-dependent, congestive cardiomyopathy', 'Myelosuppression, predominantly neutropenia and leucopenia, is the dose-limiting toxicity; in addition to this, mucositis, nausea, vomiting and alopecia are frequent, whereas hepatopathy, characterised by elevated bilirubin concentrations, occurs less frequently', 'In spite of the routine use of this drug its major adverse effect, the dose-dependent cardiotoxicity, cannot be prevented yet', 'The major adverse effect was myelosuppression', 'Cardiac toxicity is a major adverse effect caused by doxorubicin (DOX) therapy', 'Antioxidative and cardioprotective effects of Phyllanthus urinaria L. on doxorubicin-induced cardiotoxicity', 'The major adverse effect of DOX treatment in cancer patients is the onset of cardiomyopathy and heart failure']
['Cardiac toxicity is a major adverse effect caused by doxorubicin (DOX) therapy  ', 'Cardiac toxicity is a major adverse effect caused by doxorubicin (DOX) therapy. In spite of the routine use of this drug its major adverse effect, the dose-dependent cardiotoxicity, cannot be prevented yet. Cardiotoxicity is a major adverse effect of the anthracycline antibiotics and can be acute or chronic.']
['Cardiotoxicity', 'Cardiac toxicity']