Can SUMO affect calcium homeostasis?
['Increasing SUMOylation levels correlated inversely with calcium influx in sensory neurons.', 'CRMP2 deSUMOylation by SUMO proteases SENP1 and SENP2 normalized calcium influx to those in the CRMP2AAA mutant.', 'Thus, our results identify a novel role for SUMO modification in CRMP2/CaV2.2 signaling pathway', 'Moreover, SUMO1 overexpression in isolated cardiomyocytes augmented contractility and accelerated Ca(2+) decay.', ' RIM1α SUMOylation at lysine residue K502 facilitates\xa0the clustering of CaV2.1 calcium channels and\xa0enhances the Ca(2+) influx necessary for vesicular release, whereas non-SUMOylated RIM1α participates in the docking/priming of synaptic vesicles and maintenance of active zone structure. ', 'Identification and characterization of a SUMO-1 conjugation system that modifies neuronal calcium/calmodulin-dependent protein kinase II in Drosophila melanogaster.']
['Yes, SUMO proteins can affect calcium homeostasis.']
['yes']