Are people with blood group O protected against severe Malaria?
['Differential carbonylation of cytoskeletal proteins in blood group O erythrocytes: potential role in protection against severe malaria.', '. Our findings indicate a possible correlation between the protection against severe malaria in blood group O individuals and a specific pattern of 4-HNE-carbonylation of cytoskeleton proteins.', 'There is a predominance of blood group O in malaria-endemic regions, and several lines of evidence suggest that ABO blood groups may influence the outcome of P. falciparum infection', 'These data provide the first evidence that ABO blood group antigens influence macrophage clearance of P. falciparum-infected erythrocytes and suggest an additional mechanism by which blood group O may confer resistance to severe malaria.', 'Blood group phenotypes A and B are risk factors for cerebral malaria in Odisha, India.', 'type O is significantly associated with protection against CM, patients with type A and B group had increased risk for developing CM.', 'Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting.', 'Malaria has been a major selective force on the human population, and several erythrocyte polymorphisms have evolved that confer resistance to severe malaria. Plasmodium falciparum rosetting, a parasite virulence phenotype associated with severe malaria, is reduced in blood group O erythrocytes compared with groups A, B, and AB, but the contribution of the ABO blood group system to protection against severe malaria has received little attention', 'We hypothesized that blood group O may confer resistance to severe falciparum malaria through the mechanism of reduced rosetting.', 'It appears that individuals who are of blood-group O are relatively resistant to the severe disease caused by P. falciparum infection.']
['It appears that individuals who are of blood-group O are relatively resistant to the severe disease caused by P. falciparum infection.']
['yes']