Is protein CXCR4 used as a prognostic marker of cancer?
['Aberrant overexpression of CXCR4 is associated with worse overall survival, adenocarcinoma histology, distant metastasis, lymph node involvement in NSCLC.', 'CXCR4 belongs to a family of G protein-coupled cell surface receptors and has been proved to a prognostic marker in a various tumors, including esophageal squamous cell cancer. ', 'The chemokine C-X-C motif receptor 4 (CXCR4) has been found to be a prognostic marker in various types of cancer, being involved in chemotaxis, stemness and drug resistance. ', 'The chemokine receptor CXCR4 that has been shown to be implicated in PDAC tumorigenicity and aggressiveness could serve as a prognostic marker for survival after a curative-intent surgery and was associated with the pattern of tumour recurrence (distant versus local relapse).', 'XCR4 promotes tumor growth, angiogenesis and metastasis, and is a prognostic marker in a number of different types of tumors.', 'CXCR4 has been identified as a prognostic marker for acute myeloid leukemia (AML) and other malignancies. ', 'The chemokine receptor CXCR4 has been found to be a prognostic marker in various types of cancer, including breast cancer. ', 'Upregulated expression of C-X-C chemokine receptor 4 is an independent prognostic predictor for patients with gastric cancer.', 'detection of CXCR4 expression will be helpful for predicting prognosis for patients with gastric cancer.', 'The chemokine receptor CXCR4 is a marker of metastatic disease.', 'High CXCR4 level in cancer specimens independently predicts a poor outcome for patients with node-positive breast cancer.', 'Univariate and multivariate analyses demonstrated that the high levels of nuclear CXCR4 and CXCL12 expression in hepatocytes were significantly better prognostic factors for overall and hepatic disease-free survival in patients with CLM.', 'The chemokine receptor CXCR4 has been implicated in sarcoma development and has been found to be a prognostic marker for poor clinical outcome. ', 'high CXCR4 expression is correlated to shorter DFS and could be used as a prognostic marker in order to stratify melanoma patients at higher progression risk.']
['Yes, the chemokine C-X-C motif receptor 4 (CXCR4) has been found to be a prognostic marker in various types of cancer.']
['yes']