Is Alu hypomethylation associated with breast cancer?
['Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer', 'In IBC, Alu hypomethylation correlated with negative estrogen receptor (ER) status', 'In survival analyses, low Alu methylation status tended to be associated with poor disease-free survival of the patients.', 'Alu hypomethylation is probably a late event during breast cancer progression', 'prominent hypomethylation of Alu and LINE-1 in HER2 enriched subtype may be related to chromosomal instability of this specific subtype.', 'DNA methylation for three repetitive elements (LINE1, Sat2 and Alu) were analyzed in invasive ductal carcinoma of the breast, paired adjacent normal tissue and WBC from 40 breast cancer patients', 'DNA methylation for the three repetitive elements was lower in tumor compared to adjacent tissue and WBC DNA.']
['Yes, Alu elements were found to be hypomethylated in breast cancer, especially in the HER2-enriched subtype. Furthermore, Alu hypomethylation was identified as a late event during breast cancer progression, and in invasive breast cancer, tended to be associated with negative estrogen receptor status and poor disease-free survival of the patients.', 'Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer  ']
['yes']