Is there any evidence of dysregulated long non coding RNAs and Alzheimer's disease?
["lncRNAs in central nervous system (CNS) development and neurodegenerative diseases, including Alzheimer's disease (AD)", "(lncRNA) within mRNA sequences of Alzheimer's disease genes, namely, APP, APOE, PSEN1, and PSEN2", "sortilin-related receptor 1 (SORL1) is a risk gene for late-onset Alzheimer's disease (AD)", 'non-coding (nc) RNA (hereafter referred to as 51A) that maps in antisense configuration to intron 1 of the SORL1 gene', 'novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease', 'GDNFOS gene has four exons that are spliced into different isoforms. GDNFOS1 and GDNFOS2 are long noncoding RNA', 'In the MTG of AD patients, the mature GDNF peptide was down-regulated; however, the transcript of GDNF isoform from human exon 2 was up-regulated', 'The findings of novel GDNF and GDNFOS isoforms and differences in tissue expression patterns dysregulated in AD brains ', 'novel non-coding (nc) RNA (named 17A) RNA polymerase (pol) III-dependent embedded in the human G-protein-coupled receptor 51 gene (GPR51, GABA B2 receptor)', '17A is expressed in human brain, and we report that it is upregulated in cerebral tissues derived from Alzheimer disease patients', "Here we identify a conserved noncoding antisense transcript for beta-secretase-1 (BACE1), a crucial enzyme in Alzheimer's disease pathophysiology.", 'the genotype of this SNP shows different distribution in normal elders, mild cognitive impairment, and Alzheimer disease subjects, suggesting that this lincRNA may have a role in physiology and pathophysiology of human brain']
['It is becoming increasingly evident that long non coding RNAs (lncRNAs) play a role on neurodegenerative diseases such as Alzheimer (AD).  BACE1-AS, GDNFOS and 17A are examples of these lncRNAs. In some instances those lncRNAs are embedded or transcribed from the opposite strand of coding genes.']
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