How does Apolipoprotein E4 contribute to the risk of cognitive decline and late onset Alzheimer's disease?
['["Apolipoprotein E4 (E4) and type 2 diabetes are major risk factors for cognitive decline and late onset Alzheimer\'s disease (AD)", "Cardiovascular risk factors, especially hypertension, are also major risk factors for Alzheimer\'s disease (AD).", "Clusterin (Apo J) is one of the major risk factors for sporadic form of AD. ", "Hypertension is one of the major risk factors for central nervous system (CNS) disorders like stroke and Alzheimer\'s disease (AD).", "Major risk factors for AD are advancing age and diabetes. Lately, obesity has been associated with an increased risk of dementia."]']
Apolipoprotein E4 (E4) is a major risk factor for cognitive decline and late onset Alzheimer's disease (AD).
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