Does amiodarone affect thyroid hormone receptors in the myocardium?
['AM and Dron affected TR expression in the RA similarly by decreasing TRalpha 1 and beta 1 expression by about 50%', 'In the LVW, AM and Dron decreased TRbeta 1 and, interestingly, AM increased TRalpha 1.', 'n the apex, AM also increased TRalpha 2.', 'Both in treated and untreated mice, TRalpha2 mRNA had the highest density in mouse heart, whereas TRbeta2 mRNA had the lowest density. Amiodarone dose-dependently downregulated the levels of TRalpha1 and beta1 mRNA in comparison to the control.', 'amiodarone subtype selectively downregulates the TR mRNA levels in mouse myocardium in a dose-dependent manner.', 'Western blot analysis revealed no change in the expression of the ThR protein.', 'Amiodarone and T3, respectively, downregulated T3R alpha 1, T3R beta 1, T3R beta 2 (p < 0.05), but did not affect the levels of T3R alpha 2. Amiodarone and T3, added together, upregulated T3R alpha 2 and T3R beta 1 (p < 0.05) as compared to amiodarone or T3 alone.']
['Yes']
['yes']