What are the effects of ILK ablation?
['ILK knockdown had no effect on the viability or survival pathway activity pattern of MM cells.', 'We conclude that ILK does not play a prominent role in the promotion or sustenance of established MM.', 'Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts', 'Here, we show that fibroblast-restricted inactivation of ILK in mice leads to impaired healing due to a severe reduction in the number of myofibroblasts, whereas inflammatory infiltrate and vascularization of the granulation tissue are unaffected.', 'in fibroblasts, ILK is crucial for limiting RhoA activity, thus promoting TGFβ1 production, which is essential for dermal repair following injury.', 'Our results show that ILK is important for the function, but not the differentiation, of osteoclasts.', 'Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption.', 'ack of ILK in the hepatocytes imparts prolonged proliferative response not only to stimuli related to liver regeneration but also to xenobiotic chemical mitogens, such as PB.', 'Liver-specific ablation of integrin-linked kinase in mice results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration.', 'Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase.', 'ILK deficiency caused an aberrant distribution of nephrin and alpha-actinin-4 in podocytes, whereas the localization of podocin and synaptopodin remained relatively intact.', 'Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure.', 'Here we show that targeted ablation of the integrin-linked kinase (ILK) expression results in spontaneous cardiomyopathy and heart failure by 6 wk of age.', 'Together, these results suggest that ILK plays a central role in protecting the mammalian heart against cardiomyopathy and failure.', 'Our results show for the first time in vivo the significance of ILK and hepatic ECM-signaling for regulation of hepatocyte proliferation and differentiation.', 'Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly.']
['Depending on the tissue or cell where ILK is ablated we see different effects:\nAblation of ILK in heart results in dilated cardiomyopathy and spontaneous heart failure\nAblation of ILK in fibroblasts leads to impaired healing due to a severe reduction in the number of myofibroblasts\nAblation of ILK in osteoclasts inhibits bone resorption\nAblation of ILK in liver results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration and in abnormal histology\nAblation of ILK in podocytes caused an aberrant distribution of nephrin and alpha-actinin-4']
['Ablation of ILK in heart results in dilated cardiomyopathy and spontaneous heart failure', 'Ablation of ILK in fibroblasts leads to impaired healing due to a severe reduction in the number of myofibroblasts', 'Ablation of ILK in osteoclasts inhibits bone resorption', 'Ablation of ILK in liver results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration and in abnormal histology', 'Ablation of ILK in podocytes caused an aberrant distribution of nephrin and alpha-actinin-4']