Which protein is affected by dusp8 activation?
["Thus, rosiglitazone's neuroprotective effect after ischemia is mediated by blocking JNK phosphorylation induced by ischemia via DUSP8 upregulation.", 'Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase.', 'These results suggest that JNK activation by H(2)O(2) plus PDTC resulted from the down-regulation of JNK phosphatases.', 'M3/6 is a dual-specificity phosphatase selective for JNK', 'Phosphorylation of the M3/6 dual-specificity phosphatase enhances the activation of JNK by arsenite.', 'Dual-specificity phosphatases (DUSPs) play a very important role in these events by modulating the extent of JNK phosphorylation and activation and thus regulating cellular responses to stress. M3/6 (DUSP8) is one of the dual-specificity protein phosphatases with distinct specificity towards JNK', 'Both anisomycin and arsenite activate the JNK pathway and, in addition, inactivate the M3/6 phosphatase.', 'M3/6 (DUSP8) is a dual-specificity phosphatase implicated in the dephosphorylation and inactivation of JNK and, to a lesser extent, p38 MAPKs and is found in a complex with these kinases, along with other pathway components, held together by scaffold proteins.', '. We suggest that reduction of HSP70 by expanded polyglutamine is implicated in aggregation and inhibition of M3/6 and in activation of JNK and AP-1.']
['dusp8 (M3/6) is a dual-specificity phosphatase selective for JNK.']
['JNK']