Which receptor does benralizumab target for allergic asthma treatment and how does it improve outcomes?
['plete blood eosinophils and improve the clinical outcomes of allergic asthma.", "Expert opinion: Benralizumab has the advantage over other anti-IL-5 therapies to target the IL-5R\\u03b1 itself.", "Benralizumab is an anti-interleukin-5 receptor \\u03b1 monoclonal antibody that depletes blood and airway eosinophils.", "Benralizumab is a monoclonal antibody that targets interleukin-5 receptor \\u03b1 to deplete blood eosinophils and improve the clinical outcomes of allergic asthma.", "Anti-IL-5-based therapies (mepolizumab and reslizumab are humanized monoclonal antibodies (hmAbs) that recognize free IL-5, benralizumab is a hmAb directed at the \\u03b1 subunit of the IL-5R) target the IL-5-signaling in eosinophilic asthma.", "BACKGROUND Benralizumab is an anti-eosinophilic, anti-interleukin-5 receptor \\u03b1 monoclonal antibody that has been shown to significantly reduce asthma exacerbations and improve lung function for patients with severe, uncontrolled asthma.", "As IL-5 is implicated in disease states that are mediated by eosinophils, benralizumab is an attractive option for use in the management of asthma.", "INTRODUCTION Benralizumab is a monoclonal antibody that binds the \\u03b1 subunit of the receptor to IL-5.", "Benralizumab is a humanized, afucosylated, anti-interleukin-5 receptor \\u03b1, immunoglobulin G (IgG) 1 \\u03ba monoclonal antibody.", "We investigated whether benralizumab, a monoclonal antibody directed against the alpha subunit of the interleukin-5 receptor that significantly reduces the incidence of asthma exacerbations, was also effective as an oral glucocorticoid-sparing therapy in patients relying on oral glucocorticoids to manage severe asthma associated with eosinophilia.", "In a phase 2b dose-ranging study, we aimed to assess the efficacy and safety of benralizumab, an anti-interleukin 5 receptor \\u03b1 monoclonal antibody that depletes blood and airway eosinophils, in adults with uncontrolled eosinophilic asthma.", "Benralizumab, an anti-interleukin-5 receptor \\u03b1 monoclonal antibody, depletes blood and sputum eosinophils."]', 'plete blood eosinophils and improve the clinical outcomes of allergic asthma.", "Expert opinion: Benralizumab has the advantage over other anti-IL-5 therapies to target the IL-5R\\u03b1 itself.", "Benralizumab is an anti-interleukin-5 receptor \\u03b1 monoclonal antibody that depletes blood and airway eosinophils.", "Benralizumab is a monoclonal antibody that targets interleukin-5 receptor \\u03b1 to deplete blood eosinophils and improve the clinical outcomes of allergic asthma.", "Anti-IL-5-based therapies (mepolizumab and reslizumab are humanized monoclonal antibodies (hmAbs) that recognize free IL-5, benralizumab is a hmAb directed at the \\u03b1 subunit of the IL-5R) target the IL-5-signaling in eosinophilic asthma.", "BACKGROUND Benralizumab is an anti-eosinophilic, anti-interleukin-5 receptor \\u03b1 monoclonal antibody that has been shown to significantly reduce asthma exacerbations and improve lung function for patients with severe, uncontrolled asthma.", "As IL-5 is implicated in disease states that are mediated by eosinophils, benralizumab is an attractive option for use in the management of asthma.", "INTRODUCTION Benralizumab is a monoclonal antibody that binds the \\u03b1 subunit of the receptor to IL-5.", "Benralizumab is a humanized, afucosylated, anti-interleukin-5 receptor \\u03b1, immunoglobulin G (IgG) 1 \\u03ba monoclonal antibody.", "We investigated whether benralizumab, a monoclonal antibody directed against the alpha subunit of the interleukin-5 receptor that significantly reduces the incidence of asthma exacerbations, was also effective as an oral glucocorticoid-sparing therapy in patients relying on oral glucocorticoids to manage severe asthma associated with eosinophilia.", "In a phase 2b dose-ranging study, we aimed to assess the efficacy and safety of benralizumab, an anti-interleukin 5 receptor \\u03b1 monoclonal antibody that depletes blood and airway eosinophils, in adults with uncontrolled eosinophilic asthma.", "Benralizumab, an anti-interleukin-5 receptor \\u03b1 monoclonal antibody, depletes blood and sputum eosinophils."]']
Benralizumab targets the interleukin-5 receptor α to deplete blood eosinophils and improve the clinical outcomes of allergic asthma.
[]