Is exome sequencing efficient for the detection of germline mutations?
['Whole exome sequencing is an efficient and sensitive method for detection of germline mutations in patients with phaeochromcytomas and paragangliomas', 'Whole exome sequencing is sensitive, rapid and efficient for detection of PCC/PGL germline mutations.', 'These results from deep sequencing demonstrate a higher mutational detection rate than reported with conventional sequencing methodology.', 'We performed exome sequencing of germline DNA from members of the affected family. Exome-wide analysis identified a novel loss-of-function mutation in the BAP1 gene, previously suggested as a tumor suppressor.', 'whole-exome sequencing has been widely applied in the identification of germline mutations underlying Mendelian disorders, somatic mutations in various cancers and de novo mutations in neurodevelopmental disorders.']
['Exome sequencing is an efficient, sensitive, rapid and relatively cheap method for detection of germline mutations.']
['yes']