Has overexpression of sirtuins been reported to increase lifespan in budding yeast (Saccharomyces cerevisiae)?
['In addition, Sir2 overexpression prevents Rif1 deletion from disrupting Sir2 at IGS1 and shortening lifespan. ', 'Roles for sirtuin proteins at telomeres are thought to promote lifespan in yeast and mammals.', 'Overexpression of sirtuins (NAD(+)-dependent protein deacetylases) has been reported to increase lifespan in budding yeast (Saccharomyces cerevisiae)', 'When overexpressed, the NAD-dependent protein deacetylase Sir2 extends the lifespan of both budding yeast ', 'When overexpressed in primary mouse embryo fibroblasts (MEFs), SIRT1 antagonizes PML-induced acetylation of p53 and rescues PML-mediated premature cellular senescence. ']
['Overexpression of sirtuins (NAD(+)-dependent protein deacetylases) has been reported to increase lifespan in budding yeast (Saccharomyces cerevisiae).']
['yes']