How do protein misfolding and aggregation contribute to neurodegenerative disorders like ALS, PD, and AD?
['["Therapeutic agents are urgently required to cure several common and fatal neurodegenerative disorders caused by protein misfolding and aggregation, including amyotrophic lateral sclerosis (ALS), Parkinson\'s disease (PD), and Alzheimer\'s disease (AD).", "Human Hsp70 Disaggregase Reverses Parkinson\'s-Linked \\u03b1-Synuclein Amyloid Fibrils.", "Disaggregases, molecular chaperones that resolubilize protein aggregates.", "The structural basis by which Hsp104 dissolves disordered aggregates and prions is unknown."]']
Protein misfolding and aggregation contribute to neurodegenerative disorders like ALS, PD, and AD by causing common and fatal conditions that urgently require therapeutic agents. These disorders are linked to the misfolding and aggregation of proteins, leading to issues such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD).
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