What is the physiological role of LKB1 involved in Peutz-Jeghers syndrome?
['Recent functional genetic studies have pointed out that LKB1 plays a physiological role in controlling the Wnt-signaling pathway and activation of the pathway as a consequence of LKB1 haploinsufficiency might be responsible for the development of harmatomatous polyps.', 'PJS polyps from all patients showed generalized membrane and cytoplasmic localizations of beta-catenin along the mucosal endothelium.']
['LKB1 plays a physiological role in controlling the Wnt-signaling.']
['LKB1 plays a physiological role in controlling the Wnt-signaling.']