Does Apolipoprotein E (ApoE) have anti-inflammatory activity?
[' have previously reported that apolipoprotein E (apoE), a protein component of very-low-density lipoproteins (VLDL) and high-density lipoproteins and a potent plasma-borne atheroprotective factor, exerts anti-inflammatory activity in macrophages by switching the activation profile from M1 ("classic") to M2 ("alternative") in a process involving signaling via low-density lipoprotein receptor ', 'anti-inflammatory activity in macrophages ', 'Small peptides corresponding to the receptor-binding region of apoE mimic the anti-inflammatory activity of the apoE ', 'Apolipoprotein (apo) E-containing high-density lipoprotein (HDL) has antioxidant, anti-inflammatory and anti-atherogenic properties']
['Yes. ApoE has anti-inflammatory activity']
['yes']