Does SCRIB deregulation promote cancer?
['human homologs of Drosophila dlg, scrib, and lgl are cancer-associated genes.', 'Aberrant overexpression of the cell polarity module scribble in human cancer.', 'we show that Scrib is nearly universally overexpressed in cultured tumor cell lines and genetically disparate cancer patient series compared with matched normal tissues in vivo. ', 'These data uncover a previously unrecognized exploitation of Scrib for aberrant tumor cell motility and invasion, thus potentially contributing to disease progression in humans.', 'oss of miR-296 causes aberrantly increased and mislocalized Scrib in human tumors, resulting in exaggerated random cell migration and tumor cell invasiveness. ', 'Scrib levels predict tumor relapse in hepatocellular carcinoma patients.', 'Scrib heterozygosity predisposes to lung cancer', 'loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors, l', 'Scribble, a product of a well-known tumor suppressor gene', 'CD74-dependent deregulation of the tumor suppressor scribble in human epithelial and breast cancer cells.', ' scribble (SCRIB) complexes) is intricately related to advanced stages of tumour progression and invasiveness. ', 'SCRIB expression is deregulated in human prostate cancer,', 'Scrib heterozygosity initiated prostate hyperplasia', 'The clinical significance of the work in mice was highlighted by our observation that SCRIB deregulation strongly correlated with poor survival in human prostate cancer.', 'we demonstrate that scribble inhibits breast cancer formation and that deregulation of polarity pathways promotes dysplastic and neoplastic growth in mammals by disrupting morphogenesis and inhibiting cell death.', 'Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma.', 'loss of Scribble promotes invasion of cells through extracellular matrix in an organotypic culture system.', 'Scribble expression is decreased in many invasive human cancers.', 'Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling.']
['Yes, deregulation of scribble promotes cancer.']
['yes']