What role does the SHH-Gli pathway play in brain growth and medulloblastoma, in relation to WNT signaling and potential therapy with cyclopamine?
['148a having potential tumor/metastasis suppressive activity were found to be overexpressed in the WNT signaling associated medulloblastomas", "The requirement for SHH-Gli signaling in the growth of the mouse brain, together with the ability of inappropriate pathway activation in the cerebellum to cause medulloblastomas, and the inhibition of the growth of a number of brain tumors with cyclopamine, a SHH signaling inhibitor, underscores the critical role of the SHH-GLI pathway in brain growth and tumor formation", "Aberrant activation of the Hedgehog (Hh) and Wnt developmental pathways is associated with medulloblastoma, but deregulation of other molecular pathways, including insulin-like growth factor (IGF) signaling, has also been implicated in the pathogenesis of the tumor", "Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway."]', '148a having potential tumor/metastasis suppressive activity were found to be overexpressed in the WNT signaling associated medulloblastomas", "The requirement for SHH-Gli signaling in the growth of the mouse brain, together with the ability of inappropriate pathway activation in the cerebellum to cause medulloblastomas, and the inhibition of the growth of a number of brain tumors with cyclopamine, a SHH signaling inhibitor, underscores the critical role of the SHH-GLI pathway in brain growth and tumor formation", "Aberrant activation of the Hedgehog (Hh) and Wnt developmental pathways is associated with medulloblastoma, but deregulation of other molecular pathways, including insulin-like growth factor (IGF) signaling, has also been implicated in the pathogenesis of the tumor", "Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway."]']
The SHH-Gli pathway plays a critical role in brain growth and tumor formation, particularly in medulloblastomas associated with WNT signaling. Inappropriate pathway activation in the cerebellum can lead to medulloblastomas, and the growth of brain tumors can be inhibited with cyclopamine, a SHH signaling inhibitor.
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