What are Kupffer cells and what is their role?
['Kupffer cells (KCs) play a role in the development of drug induced liver injury (DILI).', 'Hepatic macrophages consist of Kupffer cells, which are originated from the fetal yolk-sack, and infiltrated bone marrow-derived monocytes/macrophages. ', 'Kupffer cells (KCs) are the main source of MMP.', 'liver, both Kupffer cells and recruited hepatic macrophages can contribute to decreased hepatic insulin sensitivity.', 'Macrophages such as Kupffer cells in the liver are multifunctional cells.', 'Kupffer cells--the resident macrophages of the liver--are able to release a tremendous array of mediators upon inflammatory conditions, such as infection, and their role in innate immunity is well described in the literature.', 'Kupffer cells are the tissue macrophages in the liver and play an important role in the defense mechanisms of the body']
['Kupffer cells (KCs)are hepatic macrophages which can secrete matrix metalloproteinases (MMPs), and can contribute to decreased hepatic insulin sensitivity. KCs may play a role in the development of drug induced liver injury (DILI)', 'Kupffer cells (KCs) play a role in the development of drug induced liver injury (DILI). Hepatic macrophages consist of Kupffer cells, which are originated from the fetal yolk-sack, and infiltrated bone marrow-derived monocytes/macrophages. ']
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