Can Diabetes be caused by a defect in a potassium chanel?
['Mutations in KATP channel genes can result in hypo- or hypersecretion of insulin, as in neonatal diabetes mellitus and congenital hyperinsulinism, respectively.', 'To date, all patients affected by neonatal diabetes due to a mutation in the pore-forming subunit of the channel (Kir6.2, KCNJ11) are heterozygous for the mutation. ', 'e report the first clinical case of neonatal diabetes caused by a homozygous KCNJ11 mutation', 'Diffuse congenital hyperinsulinism in infancy (CHI-D) arises from mutations inactivating the KATP channel;', 'We report a case of a 6-week-old infant with diabetes mellitus based on a genetic defect in the sulfonylurea receptor 1 (SUR1), an ATP-sensitive potassium (KATP) channel protein.', 'In diabetes, vascular KATP channel function is impaired.']
['Mutations in the KATP channel can lead to neonatal diabetes.', 'Mutations in KATP channel genes can result in hypo- or hypersecretion of insulin, as in neonatal diabetes mellitus and congenital hyperinsulinism, respectively.']
['yes']