What is the function of the mammalian gene Irg1?
['IRG1 is highly upregulated in murine ANA-1 macrophages by several proinflammatory cytokines and Toll-like receptor (TLR) agonists, as well as in spleen and lung of Listeria monocytogenes or Toxoplasma gondii infected mice, respectively', 'The proinflammatory cytokine-induced IRG1 protein associates with mitochondria', 'multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation', 'One of these genes, IRG1, was confirmed by single nucleotide polymorphism analysis to be involved in susceptibility. Its precise mechanism remains to be elucidated, although the analysis of gene expression data suggests it has a role in apoptosis.', 'Murine immune-responsive gene 1 (IRG1) plays significant roles in embryonic implantation and neurodegeneration', 'the IRG1 gene is differentially expressed in human fetal PBMCs and LPS-stimulated adult PBMCs.', 'we identified the immune-responsive gene 1 (IRG1), which was expressed substantially higher in lipopolysaccharide (LPS)-stimulated than in MAP-infected murine macrophage cell lines.', 'The inhibitor also blocked induction by LIF of several LIF-regulated genes in the LE including Irg1, which has been shown previously to be essential for implantation.', 'Immune-responsive gene 1 is a novel target of progesterone receptor and plays a critical role during implantation in the mouse.', 'our studies identified Irg1 as a novel target of PR in the pregnant uterus and also revealed that it is a critical regulator of the early events leading to implantation', ' This resulted in the identification of one novel P4-regulated gene that had been previously found in lipopolysaccharide-stimulated macrophages and called immune response gene-1 (Irg1) and which is the mammalian ortholog of the bacterial gene encoding methylcitrate dehydratase', 'the mammalian ortholog of methylcitrate dehydratase (immune response gene 1)', 'Here we report the isolation of a complementary DNA representing a novel gene, interferon-regulated gene 1 (IRG1). T', 'Here we report the isolation of a complementary DNA representing a novel gene, interferon-regulated gene 1 (IRG1). This gene exhibits significant homology to interferon (IFN)-alpha/beta-inducible human genes p27 and 6-16, indicating that these genes may belong to the same family', 'The level of IRG1 mRNA again rose transiently on day 4 immediately preceding implantation.', 'Although the functional roles of IRG1 and p27 remain unclear, we describe for the first time, identification of a gene family regulated by IFNalpha in both rodent and human uteri', 'Hence, the induction of IRG1 by LPS is mediated by tyrosine kinase and protein kinase C pathway.']
['Human IRG1 and mouse Irg1 mediates antiviral and antimicrobial immune responses, without its exact role having been elucidated. Irg1 has been suggested to have a role in apoptosis and to play a significant role in embryonic implantation. Irg1 is reported as the mammalian ortholog of methylcitrate dehydratase.']
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