Is the transcriptional regulator BACH1 an activator or a repressor?
['the impact of BACH1 repression on transcription', 'Bach1 is a repressor of the oxidative stress response', 'transcriptional repressor Bach-1, ', 'Bach1, a transcriptional repressor of the HMOX1 gene', 'The mechanism underlying Bach1-mediated HO-1 repression is less well understood', "Transcription factor BACH1 [BTB (broad-complex, tramtrack and bric-a-brac) and CNC (cap'n'collar protein) homology 1] binds to ARE-like sequences, functioning as a transcriptional repressor ", 'Bach1) is a transcriptional repressor of heme oxygenase-1 (HO-1)', ' its regulatory mechanism by the transcriptional repressor, BTB and CNC homology 1 (Bach1),', 'Bach1, a basic leucine zipper mammalian transcriptional repressor, negatively regulates heme oxygenase 1 (HMOX1),', 'Bach1, the negative regulator of Nrf2', 'ach1 is a transcriptional repressor of the heme oxygenase (HO)-1 gene. ', 'The inhibitory role for Bach1 may stem from its activity to repress gene expression including HO-1', 'Bach1 is a transcriptional repressor of the HO-1 gene (Hmox-1)', 'Here we show that the transcription factor Bach1 (BTB and CNC homology 1, basic leucine zipper transcription factor 1), which inhibits oxidative stress-inducible genes, is a crucial negative regulator of oxidative stress-induced cellular senescence', 'Bach1 is a transcriptional repressor of the HO-1 gene', 'Bach1 repressively controls myocardial HO-1 expression ', ' the transcriptional repressor BACH1 binds ARE-like enhancers', ' transcription factor Bach1 functions as a repressor of the enhancers of heme oxygenase-1 (HO-1) gene (Hmox-1)', 'Bach1, a transcription factor that suppresses the HO-1 gene', 'Bach1, a transcriptional repressor that is negatively regulated by heme in mammalian cells', 'Bach1 normally represses HO-1 expression. ', 'Bach1, a heme binding protein that represses gene expression', 'complexes with Bach1 repress MARE-dependent gene expression', 'transcriptional repressor Bach1', 'bach1-ablation resulted in increased expression of HO-1 ', 'Bach1 contributes to the down-regulation of ARE-regulated genes', 'evidence that BACH1 acts as a transcriptional repressor in the regulation of MARE-dependent genes', 'Bach1 forms a heterodimer with small Maf family, and functions as a repressor of the Maf recognition element (MARE) in vivo', 'ach1 is a transcriptional repressor of heme oxygenase-1 and beta-globin genes,', 'BACH1 suppresses expression of HO1', 'transcription factor Bach1 heterodimerizes with small Maf proteins to repress Maf recognition element (MARE)-dependent gene expression', ' Bach1 as a heme-regulated and hypoxia-inducible repressor for transcription of the HO-1 gene', 'Bach1, a transcriptional repressor of heme oxygenase-1 gene', 'Bach1, a heme-regulated transcriptional repressor', 'a heme-binding factor, Bach1, is a critical physiological repressor of ho-1', 'transcription repressor Bach1']
['BACH1, a basic leucine zipper mammalian transcriptional repressor, negatively regulates heme oxygenase 1 (HMOX1), a key cytoprotective enzyme that has antioxidant and anti-inflammatory activities. In the absence of elevated intracellular heme or oxidative stress, BACH1 functions as a repressor of the enhancers of heme oxygenase-1 (HO-1) gene (Hmox-1) by forming heterodimers with the small Maf proteins such as MafK. Bach1 is recruited to a subset of p53 target genes and contributes to impeding p53 action by promoting histone deacetylation.', 'BACH1 is, in most contexts, a transcriptional repressor']
['Repressor']