How has the study of ancient DNA (aDNA) been impacted by the use of refined sampling methods such as the inner part of petrous bones and the cementum layer in teeth roots?
['["Large-scale genomic analyses of ancient human populations have become feasible partly due to refined sampling methods. The inner part of petrous bones and the cementum layer in teeth roots are currently recognized as the best substrates for such research.", "Ancient DNA (aDNA) research involves invasive and destructive sampling procedures that are often incompatible with anthropological, anatomical, and bioarcheological analyses requiring intact skeletal remains. The osseous labyrinth inside the petrous bone has been shown to yield higher amounts of endogenous DNA than any other skeletal element; however, accessing this labyrinth in cases of a complete or reconstructed skull involves causing major structural damage to the cranial vault or base.", "first genome-wide ancient DNA from Anatolian Neolithic farmers, whose genetic material we obtained by extracting from petrous bones,"]']
The study of ancient DNA (aDNA) has been impacted by the use of refined sampling methods such as the inner part of petrous bones and the cementum layer in teeth roots by making large-scale genomic analyses of ancient human populations feasible. These substrates are recognized as the best for such research, allowing for the extraction of genetic material from petrous bones of Anatolian Neolithic farmers.
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