Are integrins part of the extracellular matrix?
['Several constituents of the ECM provide adhesive cues, which serve as binding sites for cell trans-membrane receptors, such as integrins.', 'We also determined that blocking β1integrins, the major class of receptors for all ECM proteins tested,', 'Here, we elucidate a cross-scale mechanism for tissue assembly and ECM remodeling involving Cadherin 2, the ECM protein Fibronectin, and its receptor Integrin α5. ', 'due to the diverse functions and variable expression of proteoglycans, matrix proteins, and integrins, it is rather difficult to identify a comprehensive therapeutic target among ECM components.', 'Integrin-dependent cell-extracellular matrix (ECM) adhesion is a determinant of spindle orientation.', 'The extracellular matrix component periostin is a secreted protein that functions as both a cell attachment protein and an autocrine or paracrine factor that signals through the cell adhesion molecule integrins αvβ3 and αvβ5. ', 'Integrin receptors connect the extracellular matrix to the cell cytoskeleton to provide essential forces and signals. ', ' the integrin, talin, and actin filament form a linear complex of which both ends are typically anchored to the extracellular matrices via integrins.', 'Integrins, a central family of cellular ECM receptors, have been implicated in these processes but their specific role in ES cell self-renewal remains unclear.', 'Attachment to the extracellular matrix is mediated by a complex of adhesion proteins, including integrins, signaling molecules, actin and actin-binding proteins, and scaffolding proteins.', 'Beta 1 integrin binding plays a role in the constant traction force generation in response to varying stiffness for cells grown on mature cardiac extracellular matrix.']
['Yes, \tintegrins are a central family of extracellular matrix receptors.']
['yes']