How were plasma levels of thyroid hormones affected by amiodarone and dronedarone treatment in Wistar rats?
['["Amiodarone resulted in increased T4, T4/T3 and rT3, whereas dronedarone did not alter the thyroid hormone profile in normal animals.", "Fifty-five Wistar rats were randomly allocated to a 2-week oral treatment with either vehicle (n=18), amiodarone (30 mg/kg, n=20), or dronedarone (30 mg/kg, n=17).", "Thyroid function was similar in the 3 groups.", "Plasma levels of T3, T4, and rT3 were changed after SR 33589 treatment except a decrease in T4 level at the highest dose whilst the T4 T3 ratio and the level of rT3 were dose-dependently increased by amiodarone treatment."]']
Amiodarone treatment resulted in increased T4, T4/T3, and rT3 levels in Wistar rats, while dronedarone did not alter the thyroid hormone profile in normal animals.
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