Is protein M3/6 a dual specificity phosphatase?
['Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus.', 'The results revealed upregulation of dual-specificity phosphatase M3/6 (DUSP8) activity at 4\xa0h of reperfusion in rat hippocampi. ', 'This study examines the molecular mechanism underlying JNK dephosphorylation and inactivation evoked by dual-specificity phosphates following cerebral ischemia.', 'Phosphatases play a particularly important role in this respect, by tightly controlling MAPK phosphorylation and activation. M3/6 (DUSP8) is a dual-specificity phosphatase implicated in the dephosphorylation and inactivation of JNK and, to a lesser extent, p38 MAPKs and is found in a complex with these kinases, along with other pathway components, held together by scaffold proteins. ', 'Dual-specificity phosphatases (DUSPs) play a very important role in these events by modulating the extent of JNK phosphorylation and activation and thus regulating cellular responses to stress. M3/6 (DUSP8) is one of the dual-specificity protein phosphatases with distinct specificity towards JNK.', 'M3/6 is a dual-specificity phosphatase selective for JNK [7, 8]. ', 'Here we describe two new dual specificity phosphatases of the CL100/MKP-1 family that are selective for inactivating ERK or JNK/SAPK and p38 MAP kinases when expressed in COS-7 cells. M3/6 is the first phosphatase of this family to display highly specific inactivation of JNK/SAPK and p38 MAP kinases. ', 'We previously demonstrated that the dual specificity phosphatases (DSPs) MKP7 and M3/6 bind the scaffold JNK-interacting protein-1 (JIP-1) and inactivate the bound subset of JNK (1).', 'the dual-specificity phosphatase M3/6', ' dual-specificity phosphatase M3/6 (DUSP8)', 'M3/6 (DUSP8) is a dual-specificity phosphatase implicated in the dephosphorylation and inactivation of JNK ', 'the M3/6 dual-specificity phosphatase', 'M3/6 (DUSP8) is one of the dual-specificity protein phosphatases with distinct specificity towards JNK', 'M3/6 is a dual-specificity phosphatase selective for JNK', 'The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases.', 'Phosphorylation of the M3/6 dual-specificity phosphatase enhances the activation of JNK by arsenite.', 'Indeed, expanded polyglutamine impaired the solubility of the dual-specificity JNK phosphatase M3/6.', 'Regulation of dual-specificity phosphatases M3/6 and hVH5 by phorbol esters.', 'M3/6 (DUSP8) is one of the dual-specificity protein phosphatases with distinct specificity towards JNK.', 'M3/6 is a dual-specificity phosphatase selective for JNK [7, 8]', 'M3/6 (DUSP8) is one of the dual-specificity protein phosphatases with distinct specificity towards JNK', 'Here we describe how diverse cellular stresses affect differently the stability and activity of a JNK-inactivating dual-specificity threonine-tyrosine phosphatase M3/6', 'M3/6 is a dual-specificity phosphatase selective for JNK [7, 8]', 'Regulation of dual-specificity phosphatases M3/6 and hVH5 by phorbol esters. Analysis of a delta-like domain.', 'The results revealed upregulation of dual-specificity phosphatase M3/6 (DUSP8) activity at 4\xa0h of reperfusion in rat hippocampi', 'Indeed, expanded polyglutamine impaired the solubility of the dual-specificity JNK phosphatase M3/6', 'Here we report that JIP-1 also binds the dual-specificity phosphatases MKP7 and M3/6 via a region independent of its JNK binding domain.', 'Differential regulation of M3/6 (DUSP8) signaling']
['M3/6 (DUSP8) is a dual-specificity phosphatase implicated in the dephosphorylation and inactivation of JNK and, to a lesser extent, p38 MAPKs.', 'Yes. Phosphatases play a particularly important role in this respect, by tightly controlling MAPK phosphorylation and activation. M3/6 (DUSP8) is a dual-specificity phosphatase implicated in the dephosphorylation and inactivation of JNK and, to a lesser extent, p38 MAPKs and is found in a complex with these kinases, along with other pathway components, held together by scaffold proteins.', 'The protein M3/6 (DUSP8) is a dual-specificity phosphatase implicated in the dephosphorylation and inactivation of JNK']
['yes']