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--- |
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license: cc-by-4.0 |
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size_categories: |
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- 100K<n<1M |
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--- |
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# Paired SARS-COV-2 heavy/light chain sequences from the Observed Antibody Space database |
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Human paired heavy/light chain amino acid sequences from the Observed Antibody Space (OAS) database obtained from SARS-COV-2 studies. |
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https://opig.stats.ox.ac.uk/webapps/oas/ |
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Please include the following citation in your work: |
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``` |
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Olsen, TH, Boyles, F, Deane, CM. Observed Antibody Space: A diverse database of cleaned, annotated, and translated unpaired and paired antibody sequences. Protein Science. 2022; 31: 141–146. https://doi.org/10.1002/pro.4205 |
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``` |
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## Data Preparation |
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This data was obtained on August 3, 2023 by searching the OAS Paired Sequence database with the following criteria: |
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- Species = "human" |
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- Disease = "SARS-COV-2" |
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This returned 704,652 filtered sequences from 3 studies split across 63 .csv.gz data unit files. These were extracted and filtered for records where both the `complete_vdj_heavy` and `complete_vdj_light` values were "T". Finally, the `sequence_alignment_aa_heavy` and `sequence_alignment_aa_light` fields were extracted into dataset and a 90/10 train/test applied. The resulting data was saved in pyarrow format. |
